miRTarBase - #MIRT252103


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pre-miRNA Information
pre-miRNA hsa-mir-499a   
Genomic Coordinates chr20: 34990376 - 34990497
Description Homo sapiens miR-499a stem-loop
Comment The mature sequence shown here represents the most commonly cloned form from large-scale cloning studies .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-499a-3p
Sequence 70| AACAUCACAGCAAGUCUGUGCU |91
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30512073 1 COSMIC
COSN8868602 4 COSMIC
COSN20079766 19 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs768246420 3 dbSNP
rs3746444 4 dbSNP
rs761417578 6 dbSNP
rs150018420 8 dbSNP
rs1406470841 9 dbSNP
rs772652105 11 dbSNP
rs1189840352 16 dbSNP
rs759966338 17 dbSNP
rs1475405341 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol NAPG   
Synonyms GAMMASNAP
Description NSF attachment protein gamma
Transcript NM_003826   
Expression
Putative miRNA Targets on NAPG
3'UTR of NAPG
(miRNA target sites are highlighted)		 
>NAPG|NM_003826|3'UTR
   1 TATTTTGCTTGCTGAAAAGAAAAGGGAAACAAAGGTAAAATCCTGACATGCCATTTCAAGGACTTGGGAATAGATTAGGG
  81 ATATCCGTACTTCATTACAGTCATGATTTTGGATCCTAATAAAGACTAGTTTTTAGTTACCATCTTCCCAAATCACTCAT
 161 TGTATCCATTACCTGTGAAGCATATCTTTTTCTTTCCATAAGAGCTTTTCTAAGACACCAGCAGGAATTAACAGAAAATG
 241 TACTGTCATGTTTTAATACATTGATTAAAAAATTTGCAAGCCAAATTATACATAAATTATGTTCTAAACAAAAGGGGTAA
 321 TAAGCATAGGTATTCTCTCTTGGACACTTGTAAGTTACTGTTAGTGAATTGTTTTTTACGTTTCATTTAATAATTGCTGC
 401 TAAAGGTGATGTTTACTGATAAATCATTTTAAAATTTTTTTGTTTTGAAAAGTAAATTTATCCCCCATGATGTTAGATAC
 481 ATTTAAATTATTAAGTCTTTTCAGAGATGAGATGGGGACAGGAAGTTATTTTGAGCCTTACAATATTATTTAGCCCAATA
 561 AAAGATGCATTGAAGCTCTTATATATTATGAGTTTGAAAAATTTTGAAGGTAGCATATTGAAGTGATCTATAAATATCTT
 641 CAGTCCTCTCTGAAGTGTGGGTATTTCTTCTATCTAAAAAATACATACAGTGACTGTCTTCAAATCTACTTGGTTCTTGA
 721 CCAAATAGGAGCTAATGGGTAATGAATACCTTTTTGTTTGTTTGTTTGTTTGTTTTGTTTTTTGTTTTTTTTTTTAAGGG
 801 TCTCACTCTTTTGCCCAGGCTGGAGTGCAGTGGCACAATCACGGCTCCCAGGCTAATGTTTTTATTTTTAATTTGTAATT
 881 TTTTTTTTATTTTTTTTGTTGAGATGGAGTTGCTCCATGTTGCACAGGCTGTTCTCAAACTCCTAAGCTCAAGCCATCTG
 961 CCTGCCTTGGCCTCCCAAAGTGCTGGGATTGTAGACATAAGCCACCTCACCCAGCCTATGAATATCTTTCTAACATTGTA
1041 AGAATGAGGTAATGTTTCCATCAGTCTAATACAGATATATTTCTTCCCTCCAAAACAGTTTATTTTGATTGTTTATTTTA
1121 TTTTGATTGTAACTCCGTCATAACTTGACATGGAAAATGCTATATACTATGAAAACTTAGCTGAAAGGGAAGAATTGTTT
1201 TAGAAAGACAATATTTAAAACACCGCACTGCCAATATATTGATCCTTTATAGTTATTTCCTAAAATGCTGTTTTCGAAAC
1281 ATTCCTTTTTCACCCTGTTGTGTGGCTTAGACCCATCTCGTAATCTGTTAATTGGAAAGAGGCTACAGACACCAGCAGTG
1361 TGCGTTCTGCAGGTACACGCTGCCAAAGTAATTCCTGCTCATCCATGCCCTGTCTCTGTCTCTTTTAGAGTCATACCTTA
1441 TTTGAGTATAGGTTGCTTAATTTTGCTAGACTTCCTGAAAACACTAAGGTGGAGTATCAGAAGTGATTTTAGTCACAGTT
1521 CTGCGGGAGAGCTTAGAATAACATCCTCCTTTGGGAGGTGGTCTCGGGTGCGTGGATGTTGGTATACAGTCTTTATTGTA
1601 AGTCTGATACAAAATGCTAATAAATTTAATGTTTTTCTTCCTTAATTTATTGGCATAGTTCTTCAGGTAGCACCTCATTT
1681 TTATTAATGATATTGGGATTAACTATGAACAAGCTATATGTAGACATTTGCATTTAAGGACATTGCAGTGTTTCAAAGAT
1761 CCCATCATTGCAGCTTGTATCCTTTAGATCCAATCGGAAACTTCTGGAGTCTTACATTAATGCTCATTTGAGCTAATTAG
1841 TAATCTGTTTAAACAGATTTGGCAATACTTTAAAGATACTGTAGACTATTTATGTATAGATAGATCATATTACCCATTAA
1921 AGTCTGGGGGAAAAAATTTTTTAATTTTACTCTTCTTATGTACTGAAAACTTTTTTTAAAAAAGGTGATGATGAAGTGCA
2001 TTCTGTAGCAGCAGCGCAGCTATGCTTTAAACCACACAAAAGGCTGTGTCCAGGTGCAGCCTCCTTCACCCTTCCTGCCC
2081 ACGGTGAGGATTGAATAACCAGGACTTGGGGATATTGTTTGTTGTCAGGGTTATTCTGTGTGGTAAGGAATATTTGTTTC
2161 ACATTTATACATTTTCTTTTTCCACTCACGTAAGTTTCTATCTTGAGAGCATAGTCCAAAGTGCAAAACTTGGTGTTTAC
2241 AAGGAAAATTGTCTTCCAGAACTCCACTGTCATCACTTTCACCAAAGTGGAAGTTTGCATGAATATGCTCAGAATCTAAT
2321 ATTCAATGTTCTGTTACATTGTAAGTGAAGTCCAGCTACAAAATAGATTTAATATATTGAATTTATTTGTACATATGCAG
2401 AGTACGGTATTTCTGTATGGAATCTGCTTTATTCCTATTTTTCCCAACTCTGATGAGTAGAATATTAAATGTGTTGTTAT
2481 GGAAATACAGATTATTGCTTCTATAGGAAGATAATTATGAAAATAAAACCTGAAACTATATAAATATAAAAAAAAAAAAA
2561 AAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucgUGUCUGA--ACGA----CACUACAa 5'
             |:| |:|  ||||    ||||||| 
Target 5' ttaATA-ATTGCTGCTAAAGGTGATGTt 3'
 387 - 413 150.00 -11.00
2 
miRNA  3' ucgUGUC---UGAACGACACUACAa 5'
             ||||   |: | |||| |||| 
Target 5' ttaACAGAAAATGTACTGTCATGTt 3'
 228 - 252 131.00 -11.90
3 
miRNA  3' ucgUGUCUGAACGACACU-ACAa 5'
             | | || | | |||| ||| 
Target 5' aaaAAATACATACAGTGACTGTc 3'
 676 - 698 123.00 -7.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30562953 13 COSMIC
COSN30496327 29 COSMIC
COSN30530682 60 COSMIC
COSN31560556 61 COSMIC
COSN20044254 68 COSMIC
COSN19702458 88 COSMIC
COSN31562230 97 COSMIC
COSN21668479 292 COSMIC
COSN6114021 380 COSMIC
COSN15663261 705 COSMIC
COSN29689002 889 COSMIC
COSN24971026 980 COSMIC
COSN9325129 1577 COSMIC
COSN23456050 1678 COSMIC
COSN30230548 2091 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs749594206 1 dbSNP
rs201815245 5 dbSNP
rs1421695479 17 dbSNP
rs1483728573 24 dbSNP
rs1190508203 30 dbSNP
rs887756893 36 dbSNP
rs1381011395 37 dbSNP
rs773143897 38 dbSNP
rs1477707227 49 dbSNP
rs763888237 50 dbSNP
rs1171927336 51 dbSNP
rs541604744 52 dbSNP
rs1258939571 69 dbSNP
rs1006212998 71 dbSNP
rs1014972621 77 dbSNP
rs1485566375 78 dbSNP
rs1278569561 81 dbSNP
rs1218355006 82 dbSNP
rs1381379633 84 dbSNP
rs962280682 87 dbSNP
rs932401718 88 dbSNP
rs1314426967 104 dbSNP
rs1322973197 114 dbSNP
rs1315511765 119 dbSNP
rs368370775 121 dbSNP
rs985252739 124 dbSNP
rs563178587 127 dbSNP
rs1466670239 128 dbSNP
rs1414042401 136 dbSNP
rs192986652 140 dbSNP
rs1035822811 142 dbSNP
rs1299740710 143 dbSNP
rs545626908 148 dbSNP
rs1036939269 150 dbSNP
rs762146177 162 dbSNP
rs1370228702 163 dbSNP
rs533874706 173 dbSNP
rs1475133509 176 dbSNP
rs1255853053 180 dbSNP
rs1196372501 181 dbSNP
rs1488812061 185 dbSNP
rs931330194 187 dbSNP
rs373033183 193 dbSNP
rs895195803 199 dbSNP
rs1265459570 201 dbSNP
rs547243709 204 dbSNP
rs1232611755 206 dbSNP
rs1332676491 223 dbSNP
rs979065969 232 dbSNP
rs1219062619 235 dbSNP
rs1158057850 240 dbSNP
rs1012286953 246 dbSNP
rs372367722 249 dbSNP
rs1412402291 250 dbSNP
rs1392983906 253 dbSNP
rs1048495 260 dbSNP
rs1326583242 272 dbSNP
rs1025073252 273 dbSNP
rs142060068 277 dbSNP
rs1475967346 282 dbSNP
rs1372824619 293 dbSNP
rs1190598124 296 dbSNP
rs1040698517 301 dbSNP
rs999676945 310 dbSNP
rs1253237783 313 dbSNP
rs1212592715 314 dbSNP
rs1031234902 315 dbSNP
rs1199151866 316 dbSNP
rs958571945 318 dbSNP
rs923107166 321 dbSNP
rs931822907 327 dbSNP
rs551185280 330 dbSNP
rs1404807661 333 dbSNP
rs369812118 335 dbSNP
rs989798228 336 dbSNP
rs1050303341 338 dbSNP
rs1304242834 347 dbSNP
rs1333986794 353 dbSNP
rs1410964904 354 dbSNP
rs569516353 357 dbSNP
rs1396235535 358 dbSNP
rs879532292 371 dbSNP
rs17547178 372 dbSNP
rs1390428927 378 dbSNP
rs1006343621 380 dbSNP
rs1036330273 381 dbSNP
rs985221742 391 dbSNP
rs1331646382 393 dbSNP
rs1452066808 404 dbSNP
rs73392661 429 dbSNP
rs1003101556 430 dbSNP
rs566826755 431 dbSNP
rs1270787134 435 dbSNP
rs1312858822 437 dbSNP
rs533962868 441 dbSNP
rs36024433 447 dbSNP
rs1013481542 449 dbSNP
rs1281357924 453 dbSNP
rs1233790202 455 dbSNP
rs1311471449 462 dbSNP
rs555372453 462 dbSNP
rs1443017768 464 dbSNP
rs1335748067 466 dbSNP
rs1416560489 467 dbSNP
rs918500987 480 dbSNP
rs1183141151 491 dbSNP
rs1172654403 494 dbSNP
rs184671071 508 dbSNP
rs758021934 510 dbSNP
rs1177344316 514 dbSNP
rs895154392 525 dbSNP
rs1231153254 534 dbSNP
rs375860232 543 dbSNP
rs1030587473 554 dbSNP
rs1046450582 555 dbSNP
rs1210445769 557 dbSNP
rs1346074487 563 dbSNP
rs1286595144 566 dbSNP
rs906649658 569 dbSNP
rs1428448138 570 dbSNP
rs999645974 571 dbSNP
rs956392537 577 dbSNP
rs1356523136 579 dbSNP
rs1053041062 581 dbSNP
rs1362125717 582 dbSNP
rs894019561 582 dbSNP
rs1352234020 583 dbSNP
rs1405111971 584 dbSNP
rs535401382 584 dbSNP
rs1164953127 594 dbSNP
rs1475460168 599 dbSNP
rs975997882 602 dbSNP
rs556735338 605 dbSNP
rs1308252015 616 dbSNP
rs1185604925 620 dbSNP
rs951678428 626 dbSNP
rs186787170 629 dbSNP
rs1006586451 633 dbSNP
rs931942048 646 dbSNP
rs545849034 648 dbSNP
rs1216724831 649 dbSNP
rs986360687 652 dbSNP
rs1282175529 660 dbSNP
rs1235686252 661 dbSNP
rs79422147 663 dbSNP
rs1293195834 667 dbSNP
rs942052994 668 dbSNP
rs1368866442 671 dbSNP
rs191305808 673 dbSNP
rs965160756 674 dbSNP
rs1342937628 676 dbSNP
rs539830198 677 dbSNP
rs183460375 678 dbSNP
rs1325030528 684 dbSNP
rs1461497492 686 dbSNP
rs1162664189 687 dbSNP
rs1417142397 687 dbSNP
rs1271032874 689 dbSNP
rs972556301 693 dbSNP
rs1036466506 694 dbSNP
rs1475171127 697 dbSNP
rs150720033 708 dbSNP
rs139177320 709 dbSNP
rs9954767 722 dbSNP
rs1468946333 727 dbSNP
rs916529338 729 dbSNP
rs1212320129 736 dbSNP
rs113658668 737 dbSNP
rs948038297 737 dbSNP
rs1296664858 739 dbSNP
rs1057154241 743 dbSNP
rs1359507104 743 dbSNP
rs563029218 745 dbSNP
rs1441058545 751 dbSNP
rs1393047296 752 dbSNP
rs1426501879 753 dbSNP
rs1467070303 753 dbSNP
rs377632744 753 dbSNP
rs532915719 753 dbSNP
rs1417694158 756 dbSNP
rs1195696145 761 dbSNP
rs1478342036 770 dbSNP
rs1490100404 772 dbSNP
rs1252400411 773 dbSNP
rs569996748 773 dbSNP
rs1192320510 775 dbSNP
rs1022179526 777 dbSNP
rs1252394426 778 dbSNP
rs1481866877 778 dbSNP
rs1204327383 780 dbSNP
rs1306096790 783 dbSNP
rs1416849190 784 dbSNP
rs904703597 784 dbSNP
rs1430846407 785 dbSNP
rs1480701234 785 dbSNP
rs535582395 785 dbSNP
rs1000549051 786 dbSNP
rs534914807 786 dbSNP
rs149961165 787 dbSNP
rs1460307397 788 dbSNP
rs865909359 789 dbSNP
rs1371969213 791 dbSNP
rs893981020 791 dbSNP
rs1377002800 796 dbSNP
rs189403072 796 dbSNP
rs1175781413 798 dbSNP
rs769895115 799 dbSNP
rs1435507468 800 dbSNP
rs1405452730 802 dbSNP
rs1171924269 805 dbSNP
rs1423162293 807 dbSNP
rs1251921250 809 dbSNP
rs976136153 809 dbSNP
rs1177095538 819 dbSNP
rs1302969206 821 dbSNP
rs1479876215 825 dbSNP
rs1259982670 832 dbSNP
rs1030037627 840 dbSNP
rs953383816 843 dbSNP
rs1346789081 852 dbSNP
rs1011104743 864 dbSNP
rs1051100440 865 dbSNP
rs78193205 876 dbSNP
rs1306233358 879 dbSNP
rs1389550814 879 dbSNP
rs372659044 880 dbSNP
rs72972844 883 dbSNP
rs1229165053 885 dbSNP
rs941853596 888 dbSNP
rs971918273 889 dbSNP
rs1025445686 890 dbSNP
rs1357504385 890 dbSNP
rs919320821 898 dbSNP
rs1288947266 899 dbSNP
rs1451959636 902 dbSNP
rs562681500 904 dbSNP
rs1223674195 906 dbSNP
rs1240225432 907 dbSNP
rs1420651432 908 dbSNP
rs1189169371 914 dbSNP
rs147607391 916 dbSNP
rs1255007083 917 dbSNP
rs952639270 925 dbSNP
rs1485919854 927 dbSNP
rs1259570180 937 dbSNP
rs1236797600 943 dbSNP
rs567370134 951 dbSNP
rs1188595982 954 dbSNP
rs1391446840 957 dbSNP
rs1442451291 959 dbSNP
rs1232498827 960 dbSNP
rs983993544 965 dbSNP
rs1057440254 977 dbSNP
rs916494660 978 dbSNP
rs1332466123 992 dbSNP
rs1162271130 996 dbSNP
rs1385773376 999 dbSNP
rs894487356 1004 dbSNP
rs1455701816 1016 dbSNP
rs1397387704 1018 dbSNP
rs969311056 1019 dbSNP
rs535318603 1023 dbSNP
rs982039948 1025 dbSNP
rs76533411 1033 dbSNP
rs1345070261 1036 dbSNP
rs1043309952 1045 dbSNP
rs1435950256 1047 dbSNP
rs575367181 1050 dbSNP
rs1322699167 1053 dbSNP
rs904670973 1054 dbSNP
rs1052934450 1059 dbSNP
rs998967658 1063 dbSNP
rs1245599689 1064 dbSNP
rs749301159 1075 dbSNP
rs915351678 1079 dbSNP
rs1227886923 1081 dbSNP
rs1031824142 1084 dbSNP
rs1327310105 1093 dbSNP
rs537439003 1099 dbSNP
rs1433035964 1103 dbSNP
rs1373233453 1108 dbSNP
rs1050648103 1111 dbSNP
rs1461322856 1131 dbSNP
rs889335674 1134 dbSNP
rs1356804008 1135 dbSNP
rs768775251 1138 dbSNP
rs542387345 1141 dbSNP
rs1282100873 1144 dbSNP
rs1186237780 1161 dbSNP
rs944945159 1163 dbSNP
rs1253018378 1170 dbSNP
rs1192938459 1177 dbSNP
rs539235168 1178 dbSNP
rs1275016633 1195 dbSNP
rs900854290 1196 dbSNP
rs993878632 1201 dbSNP
rs1459588623 1202 dbSNP
rs1186408499 1203 dbSNP
rs1025797989 1208 dbSNP
rs888242553 1225 dbSNP
rs181963779 1226 dbSNP
rs953090998 1227 dbSNP
rs1023432907 1229 dbSNP
rs1392375236 1236 dbSNP
rs1007859963 1237 dbSNP
rs774439476 1238 dbSNP
rs1034927978 1245 dbSNP
rs1411652347 1248 dbSNP
rs956901624 1251 dbSNP
rs1476744579 1253 dbSNP
rs142147425 1257 dbSNP
rs915301656 1260 dbSNP
rs1437036738 1267 dbSNP
rs762238401 1276 dbSNP
rs986262458 1277 dbSNP
rs540373927 1280 dbSNP
rs919124736 1282 dbSNP
rs764052146 1295 dbSNP
rs561619955 1298 dbSNP
rs573685076 1305 dbSNP
rs16974852 1307 dbSNP
rs144445471 1320 dbSNP
rs533710263 1321 dbSNP
rs761165015 1332 dbSNP
rs1375736211 1333 dbSNP
rs773519083 1334 dbSNP
rs1277603881 1345 dbSNP
rs1412293020 1345 dbSNP
rs1409466741 1349 dbSNP
rs551668648 1351 dbSNP
rs1349640633 1358 dbSNP
rs147900281 1364 dbSNP
rs1469503803 1370 dbSNP
rs1409651227 1374 dbSNP
rs80001658 1378 dbSNP
rs565892113 1379 dbSNP
rs1053209815 1380 dbSNP
rs766742693 1384 dbSNP
rs15937 1386 dbSNP
rs997650479 1387 dbSNP
rs1286981591 1401 dbSNP
rs1235579628 1402 dbSNP
rs1356462644 1406 dbSNP
rs1051535351 1407 dbSNP
rs1346457448 1408 dbSNP
rs1179200934 1411 dbSNP
rs888891537 1412 dbSNP
rs1034895377 1413 dbSNP
rs1399601471 1415 dbSNP
rs1386420955 1417 dbSNP
rs1007211378 1418 dbSNP
rs1166969971 1426 dbSNP
rs1475430721 1430 dbSNP
rs956681343 1434 dbSNP
rs1181503380 1437 dbSNP
rs1015975693 1438 dbSNP
rs963281089 1441 dbSNP
rs1244047055 1449 dbSNP
rs1216655283 1452 dbSNP
rs1473082727 1475 dbSNP
rs1022295153 1479 dbSNP
rs1464477066 1487 dbSNP
rs1266820581 1493 dbSNP
rs1216048741 1494 dbSNP
rs993424174 1497 dbSNP
rs1184982927 1504 dbSNP
rs1026115047 1525 dbSNP
rs554687436 1526 dbSNP
rs1270388105 1535 dbSNP
rs1429462162 1546 dbSNP
rs993294684 1549 dbSNP
rs944839560 1551 dbSNP
rs915985050 1552 dbSNP
rs970571409 1553 dbSNP
rs1327869780 1561 dbSNP
rs10207 1566 dbSNP
rs115557966 1567 dbSNP
rs569040293 1569 dbSNP
rs1187294892 1572 dbSNP
rs1307653478 1576 dbSNP
rs1448966137 1585 dbSNP
rs1246200943 1589 dbSNP
rs1369723496 1591 dbSNP
rs1196055142 1592 dbSNP
rs553545187 1592 dbSNP
rs934874524 1596 dbSNP
rs539761409 1598 dbSNP
rs1469357436 1601 dbSNP
rs929583285 1605 dbSNP
rs1047130776 1611 dbSNP
rs1273309377 1611 dbSNP
rs1227147717 1619 dbSNP
rs1343526327 1620 dbSNP
rs1339453588 1626 dbSNP
rs76649141 1629 dbSNP
rs757204285 1630 dbSNP
rs1366886424 1634 dbSNP
rs1274980444 1640 dbSNP
rs1044774129 1642 dbSNP
rs1354854785 1671 dbSNP
rs1193720288 1674 dbSNP
rs375917566 1675 dbSNP
rs573682180 1691 dbSNP
rs1175665059 1697 dbSNP
rs1003321619 1702 dbSNP
rs934161514 1706 dbSNP
rs781247750 1719 dbSNP
rs1056233128 1720 dbSNP
rs1233752731 1721 dbSNP
rs1200182601 1722 dbSNP
rs1481902542 1731 dbSNP
rs1281996529 1732 dbSNP
rs143629997 1742 dbSNP
rs1474430631 1743 dbSNP
rs888866570 1743 dbSNP
rs879196356 1745 dbSNP
rs16974856 1746 dbSNP
rs3790135 1748 dbSNP
rs1430205320 1751 dbSNP
rs966152424 1757 dbSNP
rs749465041 1764 dbSNP
rs976215080 1767 dbSNP
rs1388285186 1770 dbSNP
rs1243308200 1775 dbSNP
rs768867231 1779 dbSNP
rs544208323 1780 dbSNP
rs985046694 1783 dbSNP
rs568362920 1793 dbSNP
rs1386200325 1794 dbSNP
rs113434674 1796 dbSNP
rs148091514 1797 dbSNP
rs112407016 1812 dbSNP
rs1181972634 1813 dbSNP
rs1482261672 1816 dbSNP
rs578181952 1817 dbSNP
rs941026943 1821 dbSNP
rs1342484142 1826 dbSNP
rs1482653206 1829 dbSNP
rs1253679817 1830 dbSNP
rs1230130241 1843 dbSNP
rs774353653 1848 dbSNP
rs73942697 1853 dbSNP
rs1226387455 1855 dbSNP
rs1488357404 1861 dbSNP
rs1295371636 1868 dbSNP
rs939104684 1871 dbSNP
rs772448794 1872 dbSNP
rs1023259904 1882 dbSNP
rs773809714 1884 dbSNP
rs373759565 1889 dbSNP
rs1056674629 1897 dbSNP
rs1445374313 1899 dbSNP
rs1390072408 1900 dbSNP
rs1159026781 1902 dbSNP
rs1471829692 1907 dbSNP
rs1420406991 1908 dbSNP
rs1188229451 1910 dbSNP
rs756969011 1912 dbSNP
rs1422944692 1917 dbSNP
rs1253623361 1923 dbSNP
rs780826500 1926 dbSNP
rs892314650 1931 dbSNP
rs185417558 1937 dbSNP
rs1032950419 1938 dbSNP
rs956052309 1939 dbSNP
rs988800939 1943 dbSNP
rs903810177 1950 dbSNP
rs1007559501 1953 dbSNP
rs1017626126 1954 dbSNP
rs1310810947 1961 dbSNP
rs966080070 1964 dbSNP
rs34934801 1966 dbSNP
rs922860658 1966 dbSNP
rs542668130 1971 dbSNP
rs1456054048 1978 dbSNP
rs934273534 1979 dbSNP
rs1164253733 1985 dbSNP
rs79844355 1987 dbSNP
rs985637528 1988 dbSNP
rs766716525 1997 dbSNP
rs943062745 2001 dbSNP
rs527890314 2006 dbSNP
rs367945517 2016 dbSNP
rs1037474913 2017 dbSNP
rs1469820185 2020 dbSNP
rs898806826 2033 dbSNP
rs1209064627 2043 dbSNP
rs1310054684 2055 dbSNP
rs926307432 2064 dbSNP
rs1321512672 2067 dbSNP
rs1263925869 2072 dbSNP
rs1229816219 2073 dbSNP
rs145151974 2081 dbSNP
rs928945610 2083 dbSNP
rs776888817 2084 dbSNP
rs1373885479 2086 dbSNP
rs913666465 2087 dbSNP
rs945229143 2089 dbSNP
rs1349216666 2092 dbSNP
rs762629393 2102 dbSNP
rs1388962219 2113 dbSNP
rs895731602 2122 dbSNP
rs1429918975 2123 dbSNP
rs1043987456 2124 dbSNP
rs903739004 2128 dbSNP
rs561023976 2135 dbSNP
rs1014622601 2141 dbSNP
rs1287161216 2151 dbSNP
rs1039030055 2154 dbSNP
rs1378166303 2157 dbSNP
rs1248789714 2165 dbSNP
rs745591948 2172 dbSNP
rs1198025565 2177 dbSNP
rs901830923 2185 dbSNP
rs1466309104 2186 dbSNP
rs997948377 2188 dbSNP
rs1274158425 2189 dbSNP
rs1483540748 2189 dbSNP
rs566537526 2190 dbSNP
rs905722074 2191 dbSNP
rs1233087846 2192 dbSNP
rs1329714414 2199 dbSNP
rs1016845384 2201 dbSNP
rs1410813621 2202 dbSNP
rs1369604800 2208 dbSNP
rs1305756338 2209 dbSNP
rs1436071697 2212 dbSNP
rs1255670583 2220 dbSNP
rs1423056414 2225 dbSNP
rs970257733 2226 dbSNP
rs1365446962 2227 dbSNP
rs1369955559 2251 dbSNP
rs1472126622 2254 dbSNP
rs9317 2256 dbSNP
rs1203228699 2257 dbSNP
rs1033044024 2273 dbSNP
rs1444215216 2277 dbSNP
rs1279342277 2287 dbSNP
rs1199939115 2290 dbSNP
rs1343564082 2299 dbSNP
rs189899741 2300 dbSNP
rs1388739562 2301 dbSNP
rs1229430817 2302 dbSNP
rs533029974 2308 dbSNP
rs1458307964 2316 dbSNP
rs1300740446 2327 dbSNP
rs1416170511 2339 dbSNP
rs1030107564 2341 dbSNP
rs1332990356 2356 dbSNP
rs992275980 2359 dbSNP
rs955615138 2362 dbSNP
rs1159767614 2363 dbSNP
rs986116834 2369 dbSNP
rs1180299347 2373 dbSNP
rs1315339634 2380 dbSNP
rs368193699 2381 dbSNP
rs911372384 2385 dbSNP
rs1238257419 2390 dbSNP
rs551658913 2394 dbSNP
rs6505570 2406 dbSNP
rs376651356 2407 dbSNP
rs767330266 2414 dbSNP
rs1228395052 2415 dbSNP
rs539340927 2416 dbSNP
rs1379499797 2417 dbSNP
rs533997006 2418 dbSNP
rs1283212050 2423 dbSNP
rs895480950 2425 dbSNP
rs756030230 2427 dbSNP
rs1321158752 2428 dbSNP
rs1255453927 2436 dbSNP
rs1483729208 2438 dbSNP
rs555630688 2439 dbSNP
rs14587 2447 dbSNP
rs1422919610 2448 dbSNP
rs1166906622 2449 dbSNP
rs905815386 2463 dbSNP
rs901799723 2466 dbSNP
rs779862080 2472 dbSNP
rs1258086659 2473 dbSNP
rs558938773 2474 dbSNP
rs570312058 2479 dbSNP
rs1181385614 2480 dbSNP
rs1412562169 2481 dbSNP
rs933327036 2485 dbSNP
rs1464886178 2487 dbSNP
rs999967713 2488 dbSNP
rs1173393195 2489 dbSNP
rs538139318 2499 dbSNP
rs1054256317 2504 dbSNP
rs1322660075 2506 dbSNP
rs1466288486 2507 dbSNP
rs1288735517 2521 dbSNP
rs1048199336 2533 dbSNP
rs1343688949 2536 dbSNP
rs1297780336 2542 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 8774.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ucgUGUCUGA--ACGA----CACUACAa 5'
             |:| |:|  ||||    ||||||| 
Target 5' uuaAUA-AUUGCUGCUAAAGGUGAUGUu 3'
 		8 - 34
2 
miRNA  3' ucgugucugaacgacACUACAa 5'
                         | || | 
Target 5' ------------guuUCAUUUa 3'
 		1 - 10
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000322897.6 | 3UTR | GUUUCAUUUAAUAAUUGCUGCUAAAGGUGAUGUUUACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.792 6.3e-4 0.732 2.2e-3 13 Click to see details
GSE28544 Breast cancer -0.453 1.3e-2 -0.464 1.1e-2 24 Click to see details
GSE32688 Pancreatic cancer -0.333 3.1e-2 -0.292 5.2e-2 32 Click to see details
GSE21687 Ependynoma primary tumors -0.198 5.8e-2 -0.224 3.8e-2 64 Click to see details
GSE19350 CNS germ cell tumors -0.409 9.3e-2 0.058 4.3e-1 12 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.253 1.1e-1 0.152 2.3e-1 25 Click to see details
GSE42095 Differentiated embryonic stem cells 0.171 2.2e-1 0.241 1.3e-1 23 Click to see details
GSE38226 Liver fibrosis 0.134 2.8e-1 0.036 4.4e-1 21 Click to see details
GSE17498 Multiple myeloma -0.032 4.2e-1 -0.194 1.2e-1 40 Click to see details
GSE26953 Aortic valvular endothelial cells 0.04 4.3e-1 0.013 4.8e-1 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.003 4.9e-1 -0.283 1.1e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.003 4.9e-1 -0.283 1.1e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.003 4.9e-1 -0.283 1.1e-1 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KIRP -0.554 0.06 -0.183 0.32 9 Click to see details
THCA -0.292 0.06 -0.267 0.08 29 Click to see details
LUSC 0.848 0.08 0.800 0.1 4 Click to see details
PRAD -0.26 0.18 -0.103 0.36 14 Click to see details
KIRC 0.16 0.26 0.070 0.39 19 Click to see details
STAD -0.261 0.34 0.300 0.31 5 Click to see details
BRCA 0.363 0.38 0.500 0.33 3 Click to see details
KICH 0.044 0.45 0.152 0.34 10 Click to see details
UCEC 0.053 0.46 0.286 0.27 7 Click to see details
LIHC -0.024 0.46 -0.245 0.17 17 Click to see details
HNSC -0.03 0.47 -0.100 0.4 9 Click to see details
HNSC -0.03 0.47 -0.100 0.4 9 Click to see details
HNSC -0.03 0.47 -0.100 0.4 9 Click to see details
HNSC -0.03 0.47 -0.100 0.4 9 Click to see details
HNSC -0.03 0.47 -0.100 0.4 9 Click to see details
59 hsa-miR-499a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT130131 TXNIP thioredoxin interacting protein 2 2
MIRT133678 ETNK1 ethanolamine kinase 1 2 2
MIRT252103 NAPG NSF attachment protein gamma 2 2
MIRT260160 IGFBP4 insulin like growth factor binding protein 4 2 2
MIRT388009 DR1 down-regulator of transcription 1 2 2
MIRT441692 ABLIM1 actin binding LIM protein 1 2 6
MIRT447799 EPC2 enhancer of polycomb homolog 2 2 2
MIRT450657 STYX serine/threonine/tyrosine interacting protein 2 4
MIRT456843 ZNF460 zinc finger protein 460 2 2
MIRT464134 VPS35 VPS35, retromer complex component 2 2
MIRT465101 TSC22D3 TSC22 domain family member 3 2 4
MIRT470051 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT474146 LIMA1 LIM domain and actin binding 1 2 6
MIRT474153 LIFR LIF receptor alpha 2 2
MIRT485327 MYO1D myosin ID 2 2
MIRT496403 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT497280 MAF MAF bZIP transcription factor 2 2
MIRT500970 SPTSSA serine palmitoyltransferase small subunit A 2 2
MIRT501536 POM121C POM121 transmembrane nucleoporin C 2 6
MIRT505174 WDR76 WD repeat domain 76 2 4
MIRT505203 UQCRB ubiquinol-cytochrome c reductase binding protein 2 4
MIRT506745 LIN54 lin-54 DREAM MuvB core complex component 2 4
MIRT506799 KLHL15 kelch like family member 15 2 6
MIRT525718 DCAF12L2 DDB1 and CUL4 associated factor 12 like 2 2 2
MIRT530014 SRRM1 serine and arginine repetitive matrix 1 2 2
MIRT531457 PROSER2 proline and serine rich 2 2 2
MIRT532272 CD93 CD93 molecule 2 2
MIRT538715 CAPRIN2 caprin family member 2 2 4
MIRT547356 NAT8L N-acetyltransferase 8 like 2 2
MIRT551468 TRIM59 tripartite motif containing 59 2 2
MIRT555444 NT5C3A 5'-nucleotidase, cytosolic IIIA 2 2
MIRT555674 PGAM4 phosphoglycerate mutase family member 4 2 4
MIRT557816 FOXO1 forkhead box O1 2 2
MIRT557853 FIGN fidgetin, microtubule severing factor 2 2
MIRT557880 FEM1B fem-1 homolog B 2 4
MIRT562299 GLO1 glyoxalase I 2 2
MIRT563245 QRFPR pyroglutamylated RFamide peptide receptor 2 2
MIRT565571 SLC7A2 solute carrier family 7 member 2 2 2
MIRT566214 PTMA prothymosin, alpha 2 2
MIRT575544 Map4 microtubule-associated protein 4 2 2
MIRT609316 FXYD6 FXYD domain containing ion transport regulator 6 2 2
MIRT609362 ACOT2 acyl-CoA thioesterase 2 2 2
MIRT611163 BTLA B and T lymphocyte associated 2 4
MIRT611749 CACNA1B calcium voltage-gated channel subunit alpha1 B 2 2
MIRT615019 ELK4 ELK4, ETS transcription factor 2 2
MIRT623317 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT624550 BMPR1A bone morphogenetic protein receptor type 1A 2 2
MIRT633934 DNAH9 dynein axonemal heavy chain 9 2 2
MIRT635691 BMP10 bone morphogenetic protein 10 2 2
MIRT646438 DNAH8 dynein axonemal heavy chain 8 2 2
MIRT651940 UBN1 ubinuclein 1 2 2
MIRT663605 TBC1D22A TBC1 domain family member 22A 2 2
MIRT689759 PRR13 proline rich 13 2 2
MIRT691916 SRXN1 sulfiredoxin 1 2 2
MIRT698678 TEF TEF, PAR bZIP transcription factor 2 2
MIRT700924 PDS5A PDS5 cohesin associated factor A 2 2
MIRT707970 PDE12 phosphodiesterase 12 2 2
MIRT715290 CSTF1 cleavage stimulation factor subunit 1 2 2
MIRT722414 RARS2 arginyl-tRNA synthetase 2, mitochondrial 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-499a Erlotinib 176870 NSC718781 approved sensitive Low Osteosarcoma cell line (CD166)
hsa-mir-499a Cisplatin 5460033 NSC119875 approved resistant Low Cervical Cancer cell line (GH329, Hela, CaSki, Siha)
hsa-miR-499a-3p Trametinib 11707110 NSC758246 approved sensitive High Melanoma cell line (M14) (2uM)
hsa-miR-499a-3p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (M14) (2uM)
hsa-miR-499a-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-499a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-499a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-499a-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM47)
hsa-miR-499a-3p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-499a-3p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-499a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (RPMI2650)
hsa-miR-499a-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-499a-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-499a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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