miRTarBase - #MIRT255698


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pre-miRNA Information
pre-miRNA hsa-mir-3140   
Genomic Coordinates chr4: 152489327 - 152489416
Description Homo sapiens miR-3140 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3140-5p
Sequence 12| ACCUGAAUUACCAAAAGCUUU |32
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs916622204 2 dbSNP
rs1445802016 3 dbSNP
rs1173519977 6 dbSNP
rs765680332 20 dbSNP
Putative Targets

Gene Information
Gene Symbol BHLHE40   
Synonyms BHLHB2, Clast5, DEC1, HLHB2, SHARP-2, SHARP2, STRA13, Stra14
Description basic helix-loop-helix family member e40
Transcript NM_003670   
Expression
Putative miRNA Targets on BHLHE40
3'UTR of BHLHE40
(miRNA target sites are highlighted)		 
>BHLHE40|NM_003670|3'UTR
   1 ACTCTCTAGGGGATCCTGCTGCTTTGCTTTCCTTCCTCGCTACTTCCTAAAAAGCAACAAAAAAGTTTTTGTGAATGCTG
  81 CAAGATTGTTGCATTGTGTATACTGAGATAATCTGAGGCATGGAGAGCAGATTCAGGGTGTGTGTGTGTGTGTGTGTGTG
 161 TGTATGTGCGTGTGCGTGCACATGTGTGCCTGCGTGTTGGTATAGGACTTTAAAGCTCCTTTTGGCATAGGGAAGTCACG
 241 AAGGATTGCTTGACATCAGGAGACTTGGGGGGGATTGTAGCAGACGTCTGGGCTTTTCCCCACCCAGAGAATAGCCCCCT
 321 TCGATACACATCAGCTGGATTTTCAAAAGCTTCAAAGTCTTGGTCTGTGAGTCACTCTTCAGTTTGGGAGCTGGGTCTGT
 401 GGCTTTGATCAGAAGGTACTTTCAAAAGAGGGCTTTCCAGGGCTCAGCTCCCAACCAGCTGTTAGGACCCCACCCTTTTG
 481 CCTTTATTGTCGACGTGACTCACCAGACGTCGGGGAGAGAGAGCAGTCAGACCGAGCTTTCTGCTAACATGGGGAGGTAG
 561 CAGGCACTGGCATAGCACGGTAGTGGTTTGGGGAGGTTTCCGCAGGTCTGCTCCCCACCCCTGCCTCGGAAGAATAAAGA
 641 GAATGTAGTTCCCTACTCAGGCTTTCGTAGTGATTAGCTTACTAAGGAACTGAAAATGGGCCCCTTGTACAAGCTGAGCT
 721 GCCCCGGAGGGAGGGAGGAGTTCCCTGGGCTTCTGGCACCTGTTTCTAGGCCTAACCATTAGTACTTACTGTGCAGGGAA
 801 CCAAACCAAGGTCTGAGAAATGCGGACACCCCGAGCGAGCACCCCAAAGTGCACAAAGCTGAGTAAAAAGCTGCCCCCTT
 881 CAAACAGAACTAGACTCAGTTTTCAATTCCATCCTAAAACTCCTTTTAACCAAGCTTAGCTTCTCAAAGGCCTAACCAAG
 961 CCTTGGCACCGCCAGATCCTTTCTGTAGGCTAATTCCTCTTGCCCAACGGCATATGGAGTGTCCTTATTGCTAAAAAGGA
1041 TTCCGTCTCCTTCAAAGAAGTTTTATTTTTGGTCCAGAGTACTTGTTTTCCCGATGTGTCCAGCCAGCTCCGCAGCAGCT
1121 TTTCAAAATGCACTATGCCTGATTGCTGATCGTGTTTTAACTTTTTCTTTTCCTGTTTTTATTTTGGTATTAAGTCGTTG
1201 CCTTTATTTGTAAAGCTGTTATAAATATATATTATATAAATATATTAAAAAGGAAAATGTTTCAGATGTTTATTTGTATA
1281 ATTACTTGATTCACACAGTGAGAAAAAATGAATGTATTCCTGTTTTTGAAGAGAAGAATAATTTTTTTTTTCTCTAGGGA
1361 GAGGTACAGTGTTTATATTTTGGAGCCTTCCTGAAGGTGTAAAATTGTAAATATTTTTATCTATGAGTAAATGTTAAGTA
1441 GTTGTTTTAAAATACTTAATAAAATAATTCTTTTCCTGTGGAAGAGAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuucgaaaaccaUUAAGUCCa 5'
                      :||||||| 
Target 5' gcatggagagcaGATTCAGGg 3'
 118 - 138 141.00 -8.80
2 
miRNA  3' uuucgAAAACCAUUAAGUCca 5'
               ||||||| ||| ||  
Target 5' ttttaTTTTGGT-ATTAAGtc 3'
 1177 - 1196 115.00 -6.80
3 
miRNA  3' uuUCGAAAACCA----UUAAGUCCa 5'
            ||  | | ||     | ||||| 
Target 5' agAGAATGTAGTTCCCTACTCAGGc 3'
 638 - 662 109.00 -7.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30166561 23 COSMIC
COSN30110360 33 COSMIC
COSN14071342 39 COSMIC
COSN30139771 40 COSMIC
COSN31498984 56 COSMIC
COSN15612707 73 COSMIC
COSN23337635 101 COSMIC
COSN30177621 119 COSMIC
COSN8489357 159 COSMIC
COSN20098074 161 COSMIC
COSN20098075 162 COSMIC
COSN30654733 162 COSMIC
COSN20098071 164 COSMIC
COSN27354946 164 COSMIC
COSN30638729 164 COSMIC
COSN30732530 165 COSMIC
COSN31534310 167 COSMIC
COSN30514186 168 COSMIC
COSN23987526 170 COSMIC
COSN31589047 189 COSMIC
COSN28655905 274 COSMIC
COSN28658300 278 COSMIC
COSN1278162 305 COSMIC
COSN28201596 316 COSMIC
COSN26555618 324 COSMIC
COSN31523906 396 COSMIC
COSN24718869 456 COSMIC
COSN30540345 466 COSMIC
COSN7700026 718 COSMIC
COSN19281932 782 COSMIC
COSN27910690 917 COSMIC
COSN1951891 1054 COSMIC
COSN24299615 1109 COSMIC
COSN31486012 1165 COSMIC
COSN22873302 1166 COSMIC
COSN31529744 1168 COSMIC
COSN31548196 1184 COSMIC
COSN31537753 1198 COSMIC
COSN31570169 1206 COSMIC
COSN31516165 1344 COSMIC
COSN31569396 1352 COSMIC
COSN21844149 1434 COSMIC
COSN31584810 1469 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs774972751 4 dbSNP
rs1442058949 7 dbSNP
rs760062858 10 dbSNP
rs753865800 12 dbSNP
rs763558739 16 dbSNP
rs1214066138 17 dbSNP
rs1206443410 23 dbSNP
rs753353598 27 dbSNP
rs761399314 29 dbSNP
rs1200522065 33 dbSNP
rs764995772 37 dbSNP
rs371642469 39 dbSNP
rs751465731 40 dbSNP
rs781352483 43 dbSNP
rs1474186124 45 dbSNP
rs748249405 51 dbSNP
rs1298713024 66 dbSNP
rs1398667902 66 dbSNP
rs759533852 71 dbSNP
rs1428956238 75 dbSNP
rs1368488795 79 dbSNP
rs1165309398 99 dbSNP
rs567520251 105 dbSNP
rs1444984236 113 dbSNP
rs557774839 119 dbSNP
rs1367580183 121 dbSNP
rs929006203 127 dbSNP
rs1018179368 129 dbSNP
rs1299254041 136 dbSNP
rs1202166718 138 dbSNP
rs1208301195 138 dbSNP
rs1250315863 138 dbSNP
rs1260883534 138 dbSNP
rs1267033197 138 dbSNP
rs139879256 138 dbSNP
rs1452581707 138 dbSNP
rs56076357 138 dbSNP
rs1353817631 140 dbSNP
rs1227389396 142 dbSNP
rs1268968964 144 dbSNP
rs1403842237 145 dbSNP
rs1227916286 153 dbSNP
rs1285148538 156 dbSNP
rs113672785 159 dbSNP
rs1208300997 159 dbSNP
rs201705299 159 dbSNP
rs79071212 159 dbSNP
rs1219870257 161 dbSNP
rs1463604009 161 dbSNP
rs888597035 161 dbSNP
rs1491355357 163 dbSNP
rs772994431 163 dbSNP
rs923592233 164 dbSNP
rs13093955 165 dbSNP
rs1034589470 166 dbSNP
rs1247306848 166 dbSNP
rs1432357504 168 dbSNP
rs759051732 168 dbSNP
rs878978207 170 dbSNP
rs13070453 171 dbSNP
rs1391098226 171 dbSNP
rs1190576843 172 dbSNP
rs1245193508 173 dbSNP
rs1441898391 176 dbSNP
rs1210960333 177 dbSNP
rs1276447953 182 dbSNP
rs1014203732 183 dbSNP
rs1342618997 185 dbSNP
rs1296526061 186 dbSNP
rs1225884989 194 dbSNP
rs1384629378 195 dbSNP
rs1472550842 201 dbSNP
rs1284393752 202 dbSNP
rs1024228445 207 dbSNP
rs967437779 209 dbSNP
rs992307268 221 dbSNP
rs1332775276 224 dbSNP
rs576163457 229 dbSNP
rs917689276 230 dbSNP
rs879382055 231 dbSNP
rs1448008507 238 dbSNP
rs1182621135 240 dbSNP
rs1045214108 241 dbSNP
rs1158958045 242 dbSNP
rs1235744461 253 dbSNP
rs577820140 266 dbSNP
rs1390003140 267 dbSNP
rs1483374877 268 dbSNP
rs34883305 269 dbSNP
rs560332970 270 dbSNP
rs34870629 274 dbSNP
rs542366772 275 dbSNP
rs779438826 276 dbSNP
rs74439275 278 dbSNP
rs910465261 279 dbSNP
rs1280839224 280 dbSNP
rs944387001 281 dbSNP
rs1284455663 285 dbSNP
rs997555168 287 dbSNP
rs1052251900 289 dbSNP
rs975751789 291 dbSNP
rs1380939828 298 dbSNP
rs918886519 301 dbSNP
rs929058563 304 dbSNP
rs188926124 306 dbSNP
rs889223410 307 dbSNP
rs1404931109 308 dbSNP
rs1267330135 309 dbSNP
rs1161546976 310 dbSNP
rs530939990 313 dbSNP
rs1329768343 315 dbSNP
rs941537141 323 dbSNP
rs1179872937 328 dbSNP
rs544571242 335 dbSNP
rs755020662 339 dbSNP
rs903720973 341 dbSNP
rs1319618345 345 dbSNP
rs1285873711 346 dbSNP
rs192013328 350 dbSNP
rs1288308921 355 dbSNP
rs1014419984 359 dbSNP
rs1370205230 364 dbSNP
rs1294549184 374 dbSNP
rs1436201933 375 dbSNP
rs1045729677 382 dbSNP
rs903164930 386 dbSNP
rs999376259 392 dbSNP
rs1161619976 400 dbSNP
rs1033080893 404 dbSNP
rs1457862296 412 dbSNP
rs1411245070 423 dbSNP
rs1156874113 424 dbSNP
rs1434895312 426 dbSNP
rs1425775515 431 dbSNP
rs1190444341 432 dbSNP
rs533722850 440 dbSNP
rs957469635 446 dbSNP
rs1188386797 449 dbSNP
rs1249528963 454 dbSNP
rs1239411842 456 dbSNP
rs1468852123 458 dbSNP
rs1181907166 468 dbSNP
rs757789788 469 dbSNP
rs956546996 488 dbSNP
rs1007383717 490 dbSNP
rs1265636997 492 dbSNP
rs536079814 495 dbSNP
rs1025106768 499 dbSNP
rs969174943 504 dbSNP
rs1473825696 508 dbSNP
rs1017413008 509 dbSNP
rs1365872090 510 dbSNP
rs965951818 512 dbSNP
rs975974053 513 dbSNP
rs1388164964 515 dbSNP
rs145719941 517 dbSNP
rs1413376333 518 dbSNP
rs1290553982 522 dbSNP
rs182792652 524 dbSNP
rs1175208037 525 dbSNP
rs972275411 526 dbSNP
rs1391716161 531 dbSNP
rs984987756 532 dbSNP
rs747993570 534 dbSNP
rs1448564296 535 dbSNP
rs933293728 545 dbSNP
rs937724280 560 dbSNP
rs1055970898 562 dbSNP
rs1051772028 569 dbSNP
rs529418777 572 dbSNP
rs950318403 574 dbSNP
rs1209948267 576 dbSNP
rs548683483 579 dbSNP
rs568569869 580 dbSNP
rs998863472 581 dbSNP
rs903677091 582 dbSNP
rs1000716525 583 dbSNP
rs1201099095 590 dbSNP
rs371508699 599 dbSNP
rs1372319665 602 dbSNP
rs1031313888 603 dbSNP
rs537448379 605 dbSNP
rs771256245 608 dbSNP
rs1387992649 611 dbSNP
rs1189135465 612 dbSNP
rs1008015301 614 dbSNP
rs1451083850 616 dbSNP
rs879930303 618 dbSNP
rs1013637040 620 dbSNP
rs1024636601 628 dbSNP
rs1473793871 629 dbSNP
rs11130215 632 dbSNP
rs965840279 636 dbSNP
rs781518884 645 dbSNP
rs997462960 646 dbSNP
rs1377536034 655 dbSNP
rs1026216577 656 dbSNP
rs950470222 668 dbSNP
rs984482554 669 dbSNP
rs1172648560 679 dbSNP
rs77157534 685 dbSNP
rs534124829 686 dbSNP
rs746106852 691 dbSNP
rs916110657 698 dbSNP
rs1307047073 703 dbSNP
rs950203335 705 dbSNP
rs963484725 706 dbSNP
rs1164648342 713 dbSNP
rs1458146860 714 dbSNP
rs972222737 715 dbSNP
rs1367524965 716 dbSNP
rs1370833652 722 dbSNP
rs1254617729 726 dbSNP
rs1473271824 726 dbSNP
rs1183480110 732 dbSNP
rs1411408011 734 dbSNP
rs1482934965 736 dbSNP
rs919462840 741 dbSNP
rs1046002963 744 dbSNP
rs933594012 746 dbSNP
rs1357409037 747 dbSNP
rs988161362 747 dbSNP
rs553756846 750 dbSNP
rs1331262742 752 dbSNP
rs573898781 764 dbSNP
rs1321412617 765 dbSNP
rs1330447999 769 dbSNP
rs1227643936 774 dbSNP
rs1333892410 775 dbSNP
rs187438302 778 dbSNP
rs1389627965 783 dbSNP
rs191520834 784 dbSNP
rs943381841 786 dbSNP
rs183998579 788 dbSNP
rs1160567131 790 dbSNP
rs1276633205 792 dbSNP
rs1472585923 797 dbSNP
rs1362567106 798 dbSNP
rs1201521867 802 dbSNP
rs1254203117 812 dbSNP
rs765659944 814 dbSNP
rs1227897062 817 dbSNP
rs540443694 823 dbSNP
rs189447099 824 dbSNP
rs747512348 827 dbSNP
rs893101014 828 dbSNP
rs562018800 829 dbSNP
rs192486237 830 dbSNP
rs1276517151 832 dbSNP
rs1233735603 833 dbSNP
rs1330257137 834 dbSNP
rs1300809948 837 dbSNP
rs1436751121 841 dbSNP
rs1388904966 844 dbSNP
rs1319383171 848 dbSNP
rs1039123823 850 dbSNP
rs1201659746 851 dbSNP
rs1174783988 871 dbSNP
rs1478581074 875 dbSNP
rs901699739 877 dbSNP
rs1254277236 878 dbSNP
rs3750275 885 dbSNP
rs1192003118 895 dbSNP
rs1026118596 898 dbSNP
rs1167473808 898 dbSNP
rs1248844247 920 dbSNP
rs886360812 920 dbSNP
rs1208237064 923 dbSNP
rs1445300788 924 dbSNP
rs1280690386 926 dbSNP
rs1013501877 932 dbSNP
rs1463265378 938 dbSNP
rs1046767830 951 dbSNP
rs185625137 952 dbSNP
rs1230332855 957 dbSNP
rs1001837553 963 dbSNP
rs1296390296 966 dbSNP
rs1387229764 968 dbSNP
rs564470003 971 dbSNP
rs1015942100 972 dbSNP
rs1375362099 979 dbSNP
rs1172206035 980 dbSNP
rs963099481 988 dbSNP
rs112767189 991 dbSNP
rs1186108913 992 dbSNP
rs1474469899 998 dbSNP
rs990555058 1004 dbSNP
rs1024678517 1008 dbSNP
rs1188315227 1010 dbSNP
rs1026473234 1029 dbSNP
rs1298494388 1034 dbSNP
rs955082541 1039 dbSNP
rs1342548702 1040 dbSNP
rs770277837 1044 dbSNP
rs1273511835 1045 dbSNP
rs987720654 1046 dbSNP
rs1357868572 1055 dbSNP
rs1284340884 1056 dbSNP
rs1446609321 1061 dbSNP
rs1801739 1066 dbSNP
rs1355434221 1075 dbSNP
rs529453613 1080 dbSNP
rs910822498 1085 dbSNP
rs971570225 1093 dbSNP
rs780468996 1095 dbSNP
rs1412095789 1100 dbSNP
rs752794802 1112 dbSNP
rs1265166436 1119 dbSNP
rs981581663 1129 dbSNP
rs776961689 1132 dbSNP
rs1357519104 1133 dbSNP
rs1212108876 1145 dbSNP
rs1474909710 1149 dbSNP
rs1255348082 1152 dbSNP
rs1184205893 1158 dbSNP
rs934945239 1197 dbSNP
rs549117808 1198 dbSNP
rs914607389 1216 dbSNP
rs1202169480 1220 dbSNP
rs978761720 1222 dbSNP
rs1227262916 1226 dbSNP
rs925994907 1226 dbSNP
rs1331974357 1236 dbSNP
rs1291983952 1237 dbSNP
rs569102444 1238 dbSNP
rs34622661 1242 dbSNP
rs1298029617 1243 dbSNP
rs901937211 1244 dbSNP
rs1351887655 1245 dbSNP
rs772858014 1248 dbSNP
rs114360023 1262 dbSNP
rs1047614029 1267 dbSNP
rs756300783 1270 dbSNP
rs966378289 1281 dbSNP
rs1415689848 1282 dbSNP
rs148919791 1292 dbSNP
rs1058377 1294 dbSNP
rs1184994271 1297 dbSNP
rs1407162132 1301 dbSNP
rs1390709746 1303 dbSNP
rs533523086 1306 dbSNP
rs905137309 1309 dbSNP
rs1246953598 1319 dbSNP
rs1367635451 1324 dbSNP
rs1058380 1332 dbSNP
rs1458193427 1333 dbSNP
rs1001785054 1337 dbSNP
rs1466760541 1339 dbSNP
rs368808493 1340 dbSNP
rs1026504512 1342 dbSNP
rs1306890914 1342 dbSNP
rs898868614 1342 dbSNP
rs954873663 1342 dbSNP
rs993256652 1342 dbSNP
rs1359137610 1343 dbSNP
rs1009500416 1347 dbSNP
rs1322725256 1348 dbSNP
rs1457809283 1352 dbSNP
rs1456701129 1353 dbSNP
rs1321224226 1355 dbSNP
rs567521339 1358 dbSNP
rs1156786808 1360 dbSNP
rs1011861608 1370 dbSNP
rs751178895 1384 dbSNP
rs372924886 1387 dbSNP
rs970452250 1391 dbSNP
rs977785957 1400 dbSNP
rs1192760994 1401 dbSNP
rs1452257123 1408 dbSNP
rs1249468782 1409 dbSNP
rs1312313257 1418 dbSNP
rs1485233161 1420 dbSNP
rs1260686700 1432 dbSNP
rs1214192182 1443 dbSNP
rs964968179 1447 dbSNP
rs1058395 1454 dbSNP
rs1031849851 1456 dbSNP
rs979043381 1460 dbSNP
rs114892045 1468 dbSNP
rs1300030183 1471 dbSNP
rs1329005678 1475 dbSNP
rs562387936 1491 dbSNP
rs990440406 1499 dbSNP
rs1435943784 1504 dbSNP
rs754932397 1504 dbSNP
rs1361274958 1506 dbSNP
rs11914971 1510 dbSNP
rs943568418 1511 dbSNP
rs988898640 1514 dbSNP
rs1432604990 1518 dbSNP
rs11925620 1522 dbSNP
rs1188760354 1523 dbSNP
rs1198270585 1525 dbSNP
rs1427414968 1534 dbSNP
rs923243961 1544 dbSNP
rs949223935 1550 dbSNP
rs981912377 1551 dbSNP
rs1409491998 1552 dbSNP
rs1258795378 1557 dbSNP
rs1210683857 1558 dbSNP
rs933404767 1561 dbSNP
rs1277038665 1578 dbSNP
rs1228348115 1580 dbSNP
rs1048266550 1586 dbSNP
rs937920777 1592 dbSNP
rs907727044 1596 dbSNP
rs1397826198 1599 dbSNP
rs1356064577 1608 dbSNP
rs1312149237 1609 dbSNP
rs755899114 1610 dbSNP
rs1037618833 1617 dbSNP
rs1472189309 1624 dbSNP
rs1168853183 1626 dbSNP
rs1037660830 1627 dbSNP
rs898814892 1630 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_ControlB_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell Control B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084040. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep1 HITS-CLIP data was present in GSM1084041. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep1 HITS-CLIP data was present in GSM1084042. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep2 HITS-CLIP data was present in GSM1084043. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep2 HITS-CLIP data was present in GSM1084044. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep3 HITS-CLIP data was present in GSM1084045. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep3 HITS-CLIP data was present in GSM1084046. RNA binding protein: AGO2. Condition:CLIP_noarsenite_rep4 HITS-CLIP data was present in GSM1084047. RNA binding protein: AGO2. Condition:CLIP_arsenite_rep4 HITS-CLIP data was present in GSM1084064. RNA binding protein: AGO2. Condition:CLIP_noemetine_AbnovaAb HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084066. RNA binding protein: AGO2. Condition:CLIP_noemetine_SantaCruzAb HITS-CLIP data was present in GSM1084067. RNA binding protein: AGO2. Condition:CLIP_emetine_SantaCruzAb HITS-CLIP data was present in GSM1084068. RNA binding protein: AGO2. Condition:CLIP_noemetine_SigmaAb HITS-CLIP data was present in GSM1084069. RNA binding protein: AGO2. Condition:CLIP_emetine_SigmaAb HITS-CLIP data was present in GSM1084072. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084073. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_AbnovaAb HITS-CLIP data was present in GSM1084074. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SantaCruzAb HITS-CLIP data was present in GSM1084075. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_SantaCruzAb HITS-CLIP data was present in GSM1084076. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084077. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep1_SigmaAb HITS-CLIP data was present in GSM1084078. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084080. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084081. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084082. RNA binding protein: AGO2. Condition:CLIP_nohippuristanol_rep2_SigmaAb HITS-CLIP data was present in GSM1084083. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions BT474
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1395166. RNA binding protein: AGO. Condition:BT474 AGO HITS-CLIP Replicate 1 ...

- Pillai MM; Gillen AE; Yamamoto TM; Kline E; et al., 2014, Breast cancer research and treatment.

Article - Pillai MM; Gillen AE; Yamamoto TM; Kline E; et al.
- Breast cancer research and treatment, 2014
miRNAs regulate the expression of genes in both normal physiology and disease. While miRNAs have been demonstrated to play a pivotal role in aspects of cancer biology, these reports have generally focused on the regulation of single genes. Such single-gene approaches have significant limitations, relying on miRNA expression levels and heuristic predictions of mRNA-binding sites. This results in only circumstantial evidence of miRNA-target interaction and typically leads to large numbers of false positive predictions. Here, we used a genome-wide approach (high-throughput sequencing of RNA isolated by crosslinking immunoprecipitation, HITS-CLIP) to define direct miRNA-mRNA interactions in three breast cancer subtypes (estrogen receptor positive, Her2 amplified, and triple negative). Focusing on steroid receptor signaling, we identified two novel regulators of the ER pathway (miR-9-5p and miR-193a/b-3p), which together target multiple genes involved in ER signaling. Moreover, this approach enabled the definition of miR-9-5p as a global regulator of steroid receptor signaling in breast cancer. We show that miRNA targets and networks defined by HITS-CLIP under physiologic conditions are predictive of patient outcomes and provide global insight into miRNA regulation in breast cancer.
LinkOut: [PMID: 24906430]
Experimental Support 4 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Cardiac Tissues
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM2202480. RNA binding protein: AGO2. Condition:S5_LV_36yo_Male_AGO2_bound_RNA HITS-CLIP data was present in GSM2202476. RNA binding protein: AGO2. Condition:S1_LV_54yo_Male_AGO2_bound_RNA ...

- Spengler RM; Zhang X; Cheng C; McLendon JM; et al., 2016, Nucleic acids research.

Article - Spengler RM; Zhang X; Cheng C; McLendon JM; et al.
- Nucleic acids research, 2016
MicroRNAs (miRs) have emerged as key biological effectors in human health and disease. These small noncoding RNAs are incorporated into Argonaute (Ago) proteins, where they direct post-transcriptional gene silencing via base-pairing with target transcripts. Although miRs have become intriguing biological entities and attractive therapeutic targets, the translational impacts of miR research remain limited by a paucity of empirical miR targeting data, particularly in human primary tissues. Here, to improve our understanding of the diverse roles miRs play in cardiovascular function and disease, we applied high-throughput methods to globally profile miR:target interactions in human heart tissues. We deciphered Ago2:RNA interactions using crosslinking immunoprecipitation coupled with high-throughput sequencing (HITS-CLIP) to generate the first transcriptome-wide map of miR targeting events in human myocardium, detecting 4000 cardiac Ago2 binding sites across >2200 target transcripts. Our initial exploration of this interactome revealed an abundance of miR target sites in gene coding regions, including several sites pointing to new miR-29 functions in regulating cardiomyocyte calcium, growth and metabolism. Also, we uncovered several clinically-relevant interactions involving common genetic variants that alter miR targeting events in cardiomyopathy-associated genes. Overall, these data provide a critical resource for bolstering translational miR research in heart, and likely beyond.
LinkOut: [PMID: 27418678]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_003670 | 3UTR | UGAGAUAAUCUGAGGCAUGGAGAGCAGAUUCAGGGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_003670 | 3UTR | UGAAUGCUGCAAGAUUGUUGCAUUGUGUAUACUGAGAUAAUCUGAGGCAUGGAGAGCAGAUUCAGGGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_003670 | 3UTR | UAAAAAGCAACAAAAAAGUUUUUGUGAAUGCUGCAAGAUUGUUGCAUUGUGUAUACUGAGAUAAUCUGAGGCAUGGAGAGCAGAUUCAGGGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_003670 | 3UTR | UAUACUGAGAUAAUCUGAGGCAUGGAGAGCAGAUUCAGGGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset Chi_ControlB_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell Control B
Location of target site ENST00000256495.3 | 3UTR | CAGGGUGUGUGUGUGUGUGUGUGUGUGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1084040
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep1
Location of target site ENST00000256495.3 | 3UTR | UUCAGGGUGUGUGUGUGUGUGUGUGUGUGUGUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1084041
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep1
Location of target site ENST00000256495.3 | 3UTR | UCAGGGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM1084042
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep2
Location of target site ENST00000256495.3 | 3UTR | UCAGGGUGUGUGUGUGUGUGUGUGUGUGUGUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM1084043
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep2
Location of target site ENST00000256495.3 | 3UTR | UUCAGGGUGUGUGUGUGUGUGUGUGUGUGUGUAUGUGCGUGUGCGUGCACAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM1084044
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep3
Location of target site ENST00000256495.3 | 3UTR | UUCAGGGUGUGUGUGUGUGUGUGUGUGUGUGUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 11 for dataset GSM1084045
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep3
Location of target site ENST00000256495.3 | 3UTR | UUCAGGGUGUGUGUGUGUGUGUGUGUGUGUGUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 12 for dataset GSM1084046
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noarsenite_rep4
Location of target site ENST00000256495.3 | 3UTR | UCAGGGUGUGUGUGUGUGUGUGUGUGUGUGUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 13 for dataset GSM1084047
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_arsenite_rep4
Location of target site ENST00000256495.3 | 3UTR | UUCAGGGUGUGUGUGUGUGUGUGUGUGUGUGUAUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 14 for dataset GSM1084064
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_AbnovaAb
Location of target site ENST00000256495.3 | 3UTR | AUUCAGGGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 15 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000256495.3 | 3UTR | UUCAGGGUGUGUGUGUGUGUGUGUGUGUGUGUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 16 for dataset GSM1084066
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SantaCruzAb
Location of target site ENST00000256495.3 | 3UTR | UCAGGGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 17 for dataset GSM1084067
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SantaCruzAb
Location of target site ENST00000256495.3 | 3UTR | UCAGGGUGUGUGUGUGUGUGUGUGUGUGUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 18 for dataset GSM1084068
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_noemetine_SigmaAb
Location of target site ENST00000256495.3 | 3UTR | AUUCAGGGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 19 for dataset GSM1084069
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_SigmaAb
Location of target site ENST00000256495.3 | 3UTR | UUCAGGGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 20 for dataset GSM1084072
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_AbnovaAb
Location of target site ENST00000256495.3 | 3UTR | AUUCAGGGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 21 for dataset GSM1084073
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_AbnovaAb
Location of target site ENST00000256495.3 | 3UTR | AUUCAGGGUGUGUGUGUGUGUGUGUGUGUGUGUAUGUGCGUGUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 22 for dataset GSM1084074
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SantaCruzAb
Location of target site ENST00000256495.3 | 3UTR | UUCAGGGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 23 for dataset GSM1084075
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_SantaCruzAb
Location of target site ENST00000256495.3 | 3UTR | UCAGGGUGUGUGUGUGUGUGUGUGUGUGUGUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 24 for dataset GSM1084076
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep1_SigmaAb
Location of target site ENST00000256495.3 | 3UTR | UUCAGGGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 25 for dataset GSM1084077
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep1_SigmaAb
Location of target site ENST00000256495.3 | 3UTR | UUCAGGGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 26 for dataset GSM1084078
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_AbnovaAb
Location of target site ENST00000256495.3 | 3UTR | AUUCAGGGUGUGUGUGUGUGUGUGUGUGUGUGUAUGUGCGUGUGCGUGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 27 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000256495.3 | 3UTR | GAUUCAGGGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 28 for dataset GSM1084081
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SantaCruzAb
Location of target site ENST00000256495.3 | 3UTR | UCAGGGUGUGUGUGUGUGUGUGUGUGUGUGUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 29 for dataset GSM1084082
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_nohippuristanol_rep2_SigmaAb
Location of target site ENST00000256495.3 | 3UTR | UUCAGGGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 30 for dataset GSM1084083
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SigmaAb
Location of target site ENST00000256495.3 | 3UTR | UUCAGGGUGUGUGUGUGUGUGUGUGUGUGUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 31 for dataset GSM1395166
Method / RBP HITS-CLIP / AGO
Cell line / Condition BT474 / BT474 AGO HITS-CLIP Replicate 1
Location of target site ENST00000256495.3 | 3UTR | GGUGUGUGUGUGUGUGUGUGUGUGUGUAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 24906430 / GSE57855
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
47 hsa-miR-3140-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT104285 CLDN12 claudin 12 2 2
MIRT255698 BHLHE40 basic helix-loop-helix family member e40 2 6
MIRT442182 SRP68 signal recognition particle 68 2 6
MIRT446582 FPR2 formyl peptide receptor 2 2 2
MIRT458038 MRPL12 mitochondrial ribosomal protein L12 2 2
MIRT463006 ZNF740 zinc finger protein 740 2 2
MIRT468535 SERPINH1 serpin family H member 1 2 4
MIRT468783 SCD stearoyl-CoA desaturase 2 2
MIRT482133 AKIRIN1 akirin 1 2 2
MIRT492057 TMEM59 transmembrane protein 59 2 2
MIRT492858 NRARP NOTCH regulated ankyrin repeat protein 2 2
MIRT497701 ARL6IP6 ADP ribosylation factor like GTPase 6 interacting protein 6 2 2
MIRT498157 FEM1C fem-1 homolog C 2 8
MIRT506244 PEX13 peroxisomal biogenesis factor 13 2 6
MIRT506291 PDPK1 3-phosphoinositide dependent protein kinase 1 2 4
MIRT534293 SKIL SKI like proto-oncogene 2 4
MIRT546463 SLC39A14 solute carrier family 39 member 14 2 2
MIRT565507 SP1 Sp1 transcription factor 2 2
MIRT572485 PRR14L proline rich 14 like 2 2
MIRT573398 DLC1 DLC1 Rho GTPase activating protein 2 2
MIRT610713 POU3F3 POU class 3 homeobox 3 2 2
MIRT611829 CACNG8 calcium voltage-gated channel auxiliary subunit gamma 8 2 4
MIRT615701 NEGR1 neuronal growth regulator 1 2 2
MIRT621788 TMEM55A phosphatidylinositol-4,5-bisphosphate 4-phosphatase 2 2 2
MIRT624127 HID1 HID1 domain containing 2 2
MIRT626051 PDE4C phosphodiesterase 4C 2 2
MIRT629867 GATAD1 GATA zinc finger domain containing 1 2 2
MIRT630544 LGALS8 galectin 8 2 4
MIRT630952 PANK1 pantothenate kinase 1 2 2
MIRT634793 ENTHD1 ENTH domain containing 1 2 2
MIRT640130 CYLD CYLD lysine 63 deubiquitinase 2 2
MIRT652784 TEAD1 TEA domain transcription factor 1 2 2
MIRT654472 RANBP2 RAN binding protein 2 2 2
MIRT658126 FNBP1L formin binding protein 1 like 2 2
MIRT666203 SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 2 2
MIRT667083 OTOG otogelin 2 2
MIRT673472 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT693340 E2F2 E2F transcription factor 2 2 2
MIRT700796 PHTF2 putative homeodomain transcription factor 2 2 2
MIRT703115 GPRC5A G protein-coupled receptor class C group 5 member A 2 2
MIRT714839 SCAMP2 secretory carrier membrane protein 2 2 2
MIRT715244 DHODH dihydroorotate dehydrogenase (quinone) 2 2
MIRT717863 BICD2 BICD cargo adaptor 2 2 2
MIRT722764 SIRPB2 signal regulatory protein beta 2 2 2
MIRT723303 MOGAT1 monoacylglycerol O-acyltransferase 1 2 2
MIRT724049 GABRB1 gamma-aminobutyric acid type A receptor beta1 subunit 2 2
MIRT724219 RAB6B RAB6B, member RAS oncogene family 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3140 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-3140-5p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-3140-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-3140-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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