miRTarBase - #MIRT256047


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pre-miRNA Information
pre-miRNA hsa-mir-155   
Genomic Coordinates chr21: 25573980 - 25574044
Description Homo sapiens miR-155 stem-loop
Comment Human mir-155 is predicted based on homology to a cloned miR from mouse (MIR:MI0000177) .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-155-3p
Sequence 43| CUCCUACAUAUUAGCAUUAACA |64
Evidence Experimental
Experiments Cloned
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1181188719 6 dbSNP
rs759895287 7 dbSNP
rs200351615 8 dbSNP
rs377265631 10 dbSNP
rs1038360714 20 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
BA4I1F miR-155 Safety Biomarker (SAF) Clinical/Experimental Data Expression Decrease Blood and urinary supernatants Quantitative real-time PCR
BA4I1F miR-155 Safety Biomarker (SAF) Clinical/Experimental Data Expression Increase Kidney tissue Quantitative real-time PCR
Gene Information
Gene Symbol UBE2K   
Synonyms E2-25K, HIP2, HYPG, LIG, UBC1
Description ubiquitin conjugating enzyme E2 K
Transcript NM_001111112   
Other Transcripts NM_001111113 , NM_005339   
Expression
Putative miRNA Targets on UBE2K
3'UTR of UBE2K
(miRNA target sites are highlighted)		 
>UBE2K|NM_001111112|3'UTR
   1 GGCATAGAGAGCTGCTGATATAGTCAAGCTTGCCTCTTCTTGAGGAGCACCAACATCTGTTATTTTTAGGATTCTGCATA
  81 GATTTCTTTTAAACTGGCATTCTTGCCTAATGATGTTATCTAGGCACCATTGGAGACTGAAAAAAAAAAATCCCTGCTCT
 161 GTAAATAAAGCTAATTAAACGTCTGTGTAAATTTAAAAAGGGGAAATACTTTAATTTTTTTTCTTAATAGTGTAAAAATT
 241 CCCTGAGCTAAGCTAAAACCATGGAAGAAACATGCTACTTTAGTGTTTAGCAGTGTACCAAGACTAGCAAGAGTTTGCTT
 321 CAGGATTTTGTTGAATAATTAAGATAATATTTTGAGTGTGTCAGGGCCATTCAAATTGTTGGTGTTGCATCACAGCTACC
 401 TTAACTGTTTTTAACATGGATCCTCTGTGCCTGTGAATTTACTTGCATGCTTGTACTTGACTTCTTAGGATGGGTAGCTG
 481 AAAAGACCACCATTTTAAGCATTTGAGAATTCTTAAATATGAAATTTATTCAGAATTGAAGATGGTGACCTATTCAGAGC
 561 CTTTTTGTCCTTGTCAACAGACTGGGACAGTGTCTGATTCCCCCTTCACCCCCCCCACCCCCGCCTTGCCACACACAGCT
 641 AATATTCTAATGGTAAATTTCTCTGTATCAGGTGGGGAAATGTGCTGAAGGACAGTATGTATCCCTTGCTTCATTTTTAG
 721 GTCGTAGGTTTGGAATGTCTTGTCCCAGTTCTTCAAACACTCTTAAATTTTTCTTAAGTAATGTAAAAATGGAACTGCCA
 801 ATTTTATTTCTCTTGCAAAAATAGTAAATACTTGATGTTACATTATTCCCAGGTTTAATGAAAGAACCCAACTTAGTTTT
 881 TCAGTGAATTTGACACCTATTTTTTAGTGATGAAATTTTTCTTTGAGAACTGGCAAGGATGCAGTCAGCTGTTTGCAGTT
 961 TTTAGCCTGATTTTGGGGTCTATAGAGATTGCTTTATTGGATACTTCAAGTCATTCTTGCTTGCACTTCCCCTATTGACA
1041 CATGAAAGCTGTGTTGGTGTTTTATTGTACATACTTCAGATGCACATAGGAATAGAAGTGTGTTATAAATCTAGCTTTCT
1121 TTATGATGTTTCTGATAATACGAGAATTGAAAACTTTACCTTCTCTTGTACATAGTCAGACTATTTGTATTAAATTTACA
1201 TTTCATTCTAAGTTCAAAAGTTTGAAAATTATTAGTTTTGCAAGATCACACACTAATGTAACCATTTTATGAAGGTTGAA
1281 GTGGATTTATGCAGGCAGTTCTATATATAGAAATACAATTCTTTTTAAATTTTTAGGACCAATACAAAATAACAAAAATG
1361 TAATGGAATCAGACTGAATTAAAGTAAGGCTGTATATTGAAAGTCATATTATAAAAGGTTTGCTTTCTTTAAGTGTTATT
1441 TATCTTAAATTATAATCGTTAAATGTTTGGAAGATAATTTTTGAATCATAACGTCAGCATAACTTCATTTGACTTCTCAA
1521 TAATCTTGATACTAGAAGCAATAAAAGAACCATTATTAAATATATTGTAATGTTAAAGATGTGAAGGTTCTTCCAAAAAT
1601 TTGTAAGGCTTTCCTAATTAACAGTAAACTCTTATAGCTGATATTATTACATACTAAACACAAGTTGCTGTTTTTTCCCC
1681 ATATGTTTGCTTACGCATGTCTTTATACAATCACCTCTTTTTATTGCTGTAGTTTATTTTCTAAAGATGCCAAAGGAAAC
1761 AAGATTTTTCTTTATTTATTTTAAATACCTGAAACCTCGTACTTTATATTTTGAAGTAAGGTGGGATTGTGTGAAAATGT
1841 GGATGGTTTTTCTCCAGTGTTGGTTAGAACTACTTTTTTTAAGTGGAGGGCAACTTGGTAGTATTAGTAGAATTTGGGTT
1921 TAAAAATATCAGACACATCTACCCAGTTTATTTTTTGCCTGTATTATCAGGGTATATTTAATTGTCCTGTGGTTAAACAA
2001 AGGTGAGAGAGCTCAGAGGTTTCTAAAGGTCAAGCATTTTACATATATACATACATACATGCTCTTGGAGGCAGCTATAT
2081 CCTGCTTTGATTTTTATGCACATGAGCCCTATAGGGTTATATACTCATCTAACTACACTTCAGCATCCCCAGTGCCCAAG
2161 AAATTGGAAAGTACAATATTTGGTTTGAGACATTCTTCATAAAAGATTCTTTATTATAAAAATTTACCTCATTTACATTT
2241 AATGTGATGATCTTTTTTTTCCTTTCTGGTATATTTCCCACTGTACTGTTTGGTTTTTGTTATTCTCTTGTCTGTGGGTA
2321 GATTTAGTTACCCAAACATAGAAACTAAAGCAATTGCTTTTTTCCTCTGGTCTTAAATATGTTTGGACAAAAAGACACTA
2401 AAAGGTCAGGCCTAGGGGAAAAGTACCCTGGTGGAAATTATTTTTGTAATTCTTAATATTTTTGAGTTGGCTCCGTTTGT
2481 CAGTTTTAAAAGCCTCAAAAATTATGTTAAAAAAAAAATCCAGTGAAATCCCATTTAGGGCAGGCCGATTTGTTAGAAGT
2561 CACTGATGCTCCAGTAGGCTTTTGTTATAATCAGGCCTGTTTCCTGAGTATGTGCCTCTTTTAAAAGAAGAAATAATTAG
2641 CTGTATAGTATTTCAGTACTGATGAATGAATGAATGAATGAATGGCAGTTAGTGGACCCAAATAAGTATTCAGTGGTATA
2721 TAAATATTTGAGGAACTAGGTACTGAATTAGGTGCTCTGAGTTGGCACCCCGAAATGTTTGGAATCACGACTATGATTTA
2801 CTTAAACACGTAACACATTCAAGGATATATAAATGGAGTCTAAGTATTTTGCTTTTGAAGAGAATAATCTATGAAATGGA
2881 AGACTTGATTTTTTTTTTCATTTTTTAGAAGTAATACACATTTATGATTGTTGGCACATAAAACTATGCAAAATAATTCT
2961 TTTTAAGTATCTGTAAGAAAGAATTGGCAGTTTAAACGGATTTTGCTTATTTATGCACTACAGAATGCAGCATACTGTAT
3041 TACTGTTGAGGCTGCTTAATAAGTTTACCAATGTGAAAAGCAGATCTTGGGTATAAGTGTATGCCTGATTTGAGCTTTTA
3121 AAACTGTGCAGTAGGTGTATGGTAATGTTTTACAATCCTATGTAGCAAAATAGGAAATTATGAATTTTTGTTGTTATTGT
3201 TTTAAAGATTTAAGATGGATTGGGGTAGGGAACAGCTGGAGCCAGGTATACCTTCTAGTATGTAGAGGGAAACAATGTTT
3281 AGATAGGAAAAAGGAAGCCGTCTGTTTACAGTTAACTTTATTTCATGGACTTCTACAAAATGTTGTATTAATCACTTTTT
3361 CTAGTTCAAGGAATTTCAATTCCAGGGTACAAACCATTGATTTAAAAATTACGTTTCCATTCTTTTTAGTATCAGTTTAA
3441 AGTAAATGCTTACCATCAGCCAGTTGCTGTCACTGGGAAGAAGGCAACTTGAAGTATTTACTGATAAAATAGCCTTTATT
3521 CCCAAGTGTGACTTTTCTTCAGTGTCTACATATTATGTCACACGTTCTATTTGCACTGCTGCAATATAGATCAAAGATCT
3601 TGTGGCATAGGGGTAGGGGAGTGTTAGTATCTCCCTTGTCCCATTTGTTCTGTTACTGCTTCATTGGACTGATACACCCT
3681 CATGAACTTGCAATCACCTAAATGGAAGTCTTGAATGTGTCACCTTTTGCTTGGTTATTTCAACCATGCTGCTATATATA
3761 ATCAGGTGTGGCACAGTTTGTCAGTTTGATTATAGGTGTGAGTGGATAGAAATCATTACACTGTGCTGTTAACGATCCTT
3841 GTCTGCTTGCTGTTACCTACTTTTTACAGGCATCATAATAAAAGCTAGACTATTTCTTTGGGGGGAAAGAGACTTATTTA
3921 ATGTAATTTAAAAAACTTTTCCAATAGAAAATGAAATATTATTGAAAATAATATCTATTTTTTAGCTTTCAGCAATTGAT
4001 GGTGCTTTGTTGTGGTGTCTGCTGGAAGTCTACTGCCATTATAGGGAACCTTGCTTGTTAGCTTCTCTAGATCTCTATTC
4081 TAAACAATCTGTTAGTGATGATAAATTCTGTAGGAGGGTCTATTCTGAGCCGTTAACTTCCTGTAAGGGGAAAATGGGTG
4161 GGTTACCAGAAATACCATTGAAGCAGGGTGGGCTGTGGGGTGGAAGGTTGGGGTATTTGTCTTGAGAATTAAAAACTACG
4241 AAACACTTTTGTACACAACTGATTTTTTAAAAAATAAACACATTTTTAAAGATGTTGAATTTTTCCCCCCTTATTGGGAA
4321 TTCTTAAAAATAAATGCATGCATGTTTTCCCCTGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acAAUUACGAUUAU-----ACAUCCUc 5'
            |||:|| |:|||     ||||||| 
Target 5' tgTTAGTGATGATAAATTCTGTAGGAg 3'
 4090 - 4116 168.00 -19.90
2 
miRNA  3' acaAUUACGA----UU---AUACAUCCUc 5'
             |||||:|    ||   ||||||| | 
Target 5' tggTAATGTTTTACAATCCTATGTAGCAa 3'
 3140 - 3168 133.00 -6.82
3 
miRNA  3' acaauuACGAUUAUACAUCcuc 5'
                | |||:|||||||   
Target 5' tataccTTCTAGTATGTAGagg 3'
 3247 - 3268 128.00 -15.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30178178 6 COSMIC
COSN30503272 7 COSMIC
COSN28249992 9 COSMIC
COSN30118434 30 COSMIC
COSN30177613 78 COSMIC
COSN31527726 87 COSMIC
COSN24848075 151 COSMIC
COSN26577281 173 COSMIC
COSN31514133 254 COSMIC
COSN27163586 262 COSMIC
COSN30541237 440 COSMIC
COSN31541728 500 COSMIC
COSN28003147 608 COSMIC
COSN29125450 609 COSMIC
COSN20099969 617 COSMIC
COSN1296897 624 COSMIC
COSN27151466 778 COSMIC
COSN22751611 821 COSMIC
COSN20918420 1249 COSMIC
COSN7490198 1466 COSMIC
COSN20240288 1539 COSMIC
COSN29137403 2412 COSMIC
COSN4835740 2449 COSMIC
COSN28937039 2519 COSMIC
COSN4835741 2579 COSMIC
COSN29023020 2828 COSMIC
COSN20099972 2899 COSMIC
COSN26831731 2998 COSMIC
COSN16909237 3182 COSMIC
COSN27317501 3182 COSMIC
COSN14709596 3676 COSMIC
COSN8349496 3756 COSMIC
COSN23353999 3882 COSMIC
COSN20091031 4139 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs773197431 2 dbSNP
rs1024513772 3 dbSNP
rs778574243 4 dbSNP
rs781278062 5 dbSNP
rs1367990180 9 dbSNP
rs746114221 14 dbSNP
rs770040246 16 dbSNP
rs200943921 18 dbSNP
rs1368883822 19 dbSNP
rs971940759 22 dbSNP
rs780224155 23 dbSNP
rs368526773 25 dbSNP
rs1203247814 30 dbSNP
rs1487320271 34 dbSNP
rs1267640666 35 dbSNP
rs371912997 38 dbSNP
rs1209783753 43 dbSNP
rs1265961491 48 dbSNP
rs1451864847 50 dbSNP
rs773026274 51 dbSNP
rs1213824955 54 dbSNP
rs568751368 60 dbSNP
rs1456907937 82 dbSNP
rs1256785781 86 dbSNP
rs918819048 98 dbSNP
rs1308535676 101 dbSNP
rs768970637 107 dbSNP
rs924835015 111 dbSNP
rs934998519 112 dbSNP
rs1159267080 122 dbSNP
rs1370025718 127 dbSNP
rs760521754 131 dbSNP
rs1410669024 136 dbSNP
rs1457162654 138 dbSNP
rs1319192019 139 dbSNP
rs1398190637 140 dbSNP
rs1416071050 140 dbSNP
rs879192679 140 dbSNP
rs1355000696 145 dbSNP
rs989175849 147 dbSNP
rs914892835 152 dbSNP
rs1333692534 167 dbSNP
rs1044097829 171 dbSNP
rs931790018 173 dbSNP
rs1338936562 181 dbSNP
rs531372270 182 dbSNP
rs1438599888 190 dbSNP
rs1235844423 200 dbSNP
rs1196960478 201 dbSNP
rs1289056870 204 dbSNP
rs1050563983 210 dbSNP
rs1481263499 213 dbSNP
rs1255867587 214 dbSNP
rs551041215 215 dbSNP
rs571031145 216 dbSNP
rs1304525155 227 dbSNP
rs533703935 229 dbSNP
rs1000418599 233 dbSNP
rs553558676 247 dbSNP
rs1374866874 248 dbSNP
rs1328644418 249 dbSNP
rs1475812531 253 dbSNP
rs567505401 262 dbSNP
rs1257720990 267 dbSNP
rs1483427484 271 dbSNP
rs1199675934 272 dbSNP
rs956143640 273 dbSNP
rs998153579 274 dbSNP
rs1464416074 276 dbSNP
rs560803713 279 dbSNP
rs1173969098 282 dbSNP
rs944513257 289 dbSNP
rs1182522796 320 dbSNP
rs953997588 322 dbSNP
rs1378054771 325 dbSNP
rs556460087 326 dbSNP
rs1419127822 328 dbSNP
rs1157531149 329 dbSNP
rs772525549 346 dbSNP
rs1486908834 364 dbSNP
rs1281505237 368 dbSNP
rs1216298360 369 dbSNP
rs909950505 370 dbSNP
rs1288401687 374 dbSNP
rs1379900133 375 dbSNP
rs1311994090 387 dbSNP
rs1466817559 389 dbSNP
rs1394232090 398 dbSNP
rs962813211 401 dbSNP
rs1313292852 404 dbSNP
rs879883887 407 dbSNP
rs994694020 411 dbSNP
rs1453925398 413 dbSNP
rs1367361916 428 dbSNP
rs1162014456 430 dbSNP
rs1476492326 446 dbSNP
rs939516664 448 dbSNP
rs1193459134 450 dbSNP
rs1027647899 469 dbSNP
rs1264207828 474 dbSNP
rs773705706 494 dbSNP
rs183773736 508 dbSNP
rs1263763516 515 dbSNP
rs1308912689 523 dbSNP
rs544642733 525 dbSNP
rs1349908966 527 dbSNP
rs1408102477 543 dbSNP
rs1013012606 546 dbSNP
rs1336886944 557 dbSNP
rs766722696 568 dbSNP
rs1303245654 569 dbSNP
rs1217824753 574 dbSNP
rs1312706711 578 dbSNP
rs1338138592 586 dbSNP
rs201754771 589 dbSNP
rs916846257 589 dbSNP
rs1254010995 591 dbSNP
rs1291313515 601 dbSNP
rs1024773772 602 dbSNP
rs1344103652 606 dbSNP
rs1419260228 607 dbSNP
rs1477080495 607 dbSNP
rs1451280893 608 dbSNP
rs558251995 608 dbSNP
rs1012247564 609 dbSNP
rs1337299277 609 dbSNP
rs3839130 609 dbSNP
rs1205388524 610 dbSNP
rs904268028 611 dbSNP
rs1250655689 612 dbSNP
rs370221019 613 dbSNP
rs578153864 614 dbSNP
rs1491107078 616 dbSNP
rs368041259 617 dbSNP
rs374446588 617 dbSNP
rs1491066115 618 dbSNP
rs202148499 618 dbSNP
rs891591539 618 dbSNP
rs1491215417 619 dbSNP
rs1434250678 621 dbSNP
rs1445355736 623 dbSNP
rs1161167861 624 dbSNP
rs1355620057 626 dbSNP
rs1393628885 628 dbSNP
rs1064268 630 dbSNP
rs1432054932 632 dbSNP
rs1169411178 634 dbSNP
rs1370199673 636 dbSNP
rs1427827499 638 dbSNP
rs1031830968 639 dbSNP
rs187932422 646 dbSNP
rs1196203442 650 dbSNP
rs1344030190 655 dbSNP
rs957633279 658 dbSNP
rs1277819943 664 dbSNP
rs1295359619 664 dbSNP
rs1236060986 668 dbSNP
rs140325930 670 dbSNP
rs1386120891 676 dbSNP
rs914945353 678 dbSNP
rs1367042576 679 dbSNP
rs1006880586 681 dbSNP
rs1016979234 703 dbSNP
rs1400495085 704 dbSNP
rs1228889987 705 dbSNP
rs963113377 719 dbSNP
rs1273387432 722 dbSNP
rs1379869724 724 dbSNP
rs529532479 725 dbSNP
rs918676232 736 dbSNP
rs985915169 736 dbSNP
rs776737340 749 dbSNP
rs1441716364 752 dbSNP
rs1255143163 759 dbSNP
rs960878169 760 dbSNP
rs1348179198 761 dbSNP
rs944458711 765 dbSNP
rs192977330 769 dbSNP
rs1352205593 770 dbSNP
rs1280699555 775 dbSNP
rs1447957658 775 dbSNP
rs764854546 777 dbSNP
rs948335453 782 dbSNP
rs1315216399 788 dbSNP
rs879689625 802 dbSNP
rs1360180231 805 dbSNP
rs1157195336 810 dbSNP
rs542937036 816 dbSNP
rs1402583109 817 dbSNP
rs546473202 823 dbSNP
rs1162671787 826 dbSNP
rs894480951 829 dbSNP
rs935668704 831 dbSNP
rs1255257235 835 dbSNP
rs531179770 838 dbSNP
rs1390020093 858 dbSNP
rs550978007 859 dbSNP
rs765367602 868 dbSNP
rs1262106622 869 dbSNP
rs1167231102 872 dbSNP
rs1448310442 882 dbSNP
rs1284348711 899 dbSNP
rs570967934 900 dbSNP
rs1013311935 911 dbSNP
rs1052843991 912 dbSNP
rs891557275 913 dbSNP
rs1234363473 916 dbSNP
rs1340289038 931 dbSNP
rs1287426089 933 dbSNP
rs933821093 937 dbSNP
rs1345971159 940 dbSNP
rs527387229 942 dbSNP
rs1024409164 951 dbSNP
rs1459919767 957 dbSNP
rs1050943286 967 dbSNP
rs74984195 969 dbSNP
rs77569533 971 dbSNP
rs889697586 976 dbSNP
rs1006849526 977 dbSNP
rs1422668568 978 dbSNP
rs547134916 979 dbSNP
rs907309882 983 dbSNP
rs115213470 991 dbSNP
rs1242319399 997 dbSNP
rs1031884898 1001 dbSNP
rs994589982 1009 dbSNP
rs533908997 1014 dbSNP
rs1296588995 1019 dbSNP
rs961098662 1022 dbSNP
rs1317775490 1027 dbSNP
rs1293918788 1033 dbSNP
rs185074607 1035 dbSNP
rs879934612 1036 dbSNP
rs1274453680 1038 dbSNP
rs1438884492 1040 dbSNP
rs1389575597 1043 dbSNP
rs1313031290 1049 dbSNP
rs1320543957 1053 dbSNP
rs1011838103 1057 dbSNP
rs1023794665 1058 dbSNP
rs1353811987 1072 dbSNP
rs1028555214 1086 dbSNP
rs549782889 1087 dbSNP
rs1419875965 1090 dbSNP
rs1228739179 1106 dbSNP
rs1192609066 1115 dbSNP
rs1271748365 1116 dbSNP
rs1452126813 1128 dbSNP
rs1466635729 1132 dbSNP
rs953086348 1142 dbSNP
rs569952764 1143 dbSNP
rs979616764 1145 dbSNP
rs757835609 1164 dbSNP
rs925537793 1166 dbSNP
rs1250101495 1169 dbSNP
rs1485119565 1174 dbSNP
rs1183773549 1180 dbSNP
rs911541876 1181 dbSNP
rs1278256932 1186 dbSNP
rs1232383181 1209 dbSNP
rs1038561073 1249 dbSNP
rs1304291111 1254 dbSNP
rs1446062615 1259 dbSNP
rs538205489 1262 dbSNP
rs1423260289 1268 dbSNP
rs1162883683 1275 dbSNP
rs1414366271 1282 dbSNP
rs1296384118 1292 dbSNP
rs1457690409 1297 dbSNP
rs1354913886 1299 dbSNP
rs1172709695 1304 dbSNP
rs1432513233 1305 dbSNP
rs565224098 1306 dbSNP
rs60727913 1308 dbSNP
rs578106452 1314 dbSNP
rs1449982847 1315 dbSNP
rs1303008201 1331 dbSNP
rs919096866 1341 dbSNP
rs1050912925 1343 dbSNP
rs930441717 1345 dbSNP
rs1378002477 1354 dbSNP
rs534279581 1356 dbSNP
rs1226328740 1359 dbSNP
rs1048987155 1361 dbSNP
rs1237265619 1393 dbSNP
rs1209123248 1395 dbSNP
rs915787506 1397 dbSNP
rs866188997 1398 dbSNP
rs532405686 1404 dbSNP
rs1229515498 1406 dbSNP
rs1239603631 1411 dbSNP
rs1315191306 1412 dbSNP
rs1309167240 1413 dbSNP
rs1393077019 1417 dbSNP
rs190114896 1418 dbSNP
rs1312076370 1423 dbSNP
rs1412679499 1428 dbSNP
rs1376940461 1431 dbSNP
rs1313105369 1436 dbSNP
rs1445587436 1441 dbSNP
rs1452499621 1441 dbSNP
rs866633891 1443 dbSNP
rs1361573876 1445 dbSNP
rs181633173 1455 dbSNP
rs1046171099 1457 dbSNP
rs751465781 1458 dbSNP
rs907198861 1459 dbSNP
rs896563953 1463 dbSNP
rs145375096 1464 dbSNP
rs1258558378 1466 dbSNP
rs1486857240 1466 dbSNP
rs1204792243 1467 dbSNP
rs1023679998 1473 dbSNP
rs1472978200 1474 dbSNP
rs969495691 1475 dbSNP
rs543227814 1481 dbSNP
rs979587272 1489 dbSNP
rs1317499101 1493 dbSNP
rs1292567313 1494 dbSNP
rs1053160077 1498 dbSNP
rs1357116436 1499 dbSNP
rs1032575655 1500 dbSNP
rs1381307239 1507 dbSNP
rs1405720317 1511 dbSNP
rs1290135731 1520 dbSNP
rs1415896827 1521 dbSNP
rs1176522798 1531 dbSNP
rs893325779 1533 dbSNP
rs563005818 1535 dbSNP
rs73145259 1544 dbSNP
rs1028477620 1545 dbSNP
rs1309512705 1548 dbSNP
rs1192877492 1552 dbSNP
rs137928176 1564 dbSNP
rs1008475666 1568 dbSNP
rs1468085531 1572 dbSNP
rs955027566 1577 dbSNP
rs758706892 1578 dbSNP
rs1211753069 1579 dbSNP
rs1336767785 1580 dbSNP
rs1019057659 1582 dbSNP
rs1279422423 1587 dbSNP
rs1284599224 1595 dbSNP
rs1226357308 1600 dbSNP
rs1324372498 1603 dbSNP
rs1297234451 1605 dbSNP
rs965647187 1609 dbSNP
rs142395700 1610 dbSNP
rs1369630912 1622 dbSNP
rs918985308 1630 dbSNP
rs910986328 1633 dbSNP
rs184742325 1636 dbSNP
rs1312026912 1638 dbSNP
rs1460761702 1648 dbSNP
rs984620392 1671 dbSNP
rs919841095 1677 dbSNP
rs1453943819 1682 dbSNP
rs929917239 1695 dbSNP
rs547159621 1696 dbSNP
rs1469784060 1703 dbSNP
rs896441286 1707 dbSNP
rs548731098 1711 dbSNP
rs1337195867 1727 dbSNP
rs1252794273 1730 dbSNP
rs374814749 1743 dbSNP
rs1369736082 1753 dbSNP
rs1300654071 1765 dbSNP
rs757651589 1767 dbSNP
rs1442442030 1775 dbSNP
rs905307813 1784 dbSNP
rs1328769707 1785 dbSNP
rs1478962598 1788 dbSNP
rs1000973795 1789 dbSNP
rs1191751669 1790 dbSNP
rs529819982 1792 dbSNP
rs928635703 1799 dbSNP
rs1032955212 1800 dbSNP
rs112988404 1808 dbSNP
rs1454738886 1830 dbSNP
rs1053205741 1853 dbSNP
rs1181020434 1858 dbSNP
rs1010193748 1875 dbSNP
rs1252445974 1894 dbSNP
rs1205547367 1896 dbSNP
rs781488035 1899 dbSNP
rs145939184 1902 dbSNP
rs1370797405 1904 dbSNP
rs1011648640 1907 dbSNP
rs1278381496 1911 dbSNP
rs1050385888 1919 dbSNP
rs986484664 1930 dbSNP
rs1414528634 1944 dbSNP
rs1314998313 1950 dbSNP
rs889950246 1950 dbSNP
rs1439192837 1955 dbSNP
rs1276000567 1965 dbSNP
rs368157424 1970 dbSNP
rs973925859 1977 dbSNP
rs1365443210 1985 dbSNP
rs1182689451 2005 dbSNP
rs1276955927 2006 dbSNP
rs1008902107 2020 dbSNP
rs1019823018 2022 dbSNP
rs569807224 2030 dbSNP
rs1212599133 2043 dbSNP
rs901537522 2044 dbSNP
rs1442567130 2046 dbSNP
rs1204784849 2047 dbSNP
rs1221522464 2051 dbSNP
rs993096736 2052 dbSNP
rs533692045 2053 dbSNP
rs917847547 2055 dbSNP
rs1295431635 2058 dbSNP
rs538933263 2059 dbSNP
rs1222161185 2060 dbSNP
rs1246072370 2084 dbSNP
rs1452273110 2085 dbSNP
rs1190273916 2086 dbSNP
rs1390835529 2102 dbSNP
rs949368261 2107 dbSNP
rs1448487629 2108 dbSNP
rs1474808224 2121 dbSNP
rs1415395296 2134 dbSNP
rs1189748610 2137 dbSNP
rs1472933242 2139 dbSNP
rs1241131122 2140 dbSNP
rs779275748 2143 dbSNP
rs984554803 2160 dbSNP
rs1269382964 2161 dbSNP
rs372359500 2175 dbSNP
rs1333282672 2181 dbSNP
rs571653678 2184 dbSNP
rs534213800 2185 dbSNP
rs189648908 2190 dbSNP
rs180847218 2200 dbSNP
rs928507275 2209 dbSNP
rs746400091 2212 dbSNP
rs934550354 2214 dbSNP
rs988834481 2220 dbSNP
rs772173903 2222 dbSNP
rs914573861 2223 dbSNP
rs1325231274 2226 dbSNP
rs1394402671 2243 dbSNP
rs947484650 2248 dbSNP
rs1392136102 2250 dbSNP
rs1166712214 2253 dbSNP
rs372943361 2253 dbSNP
rs1405706822 2258 dbSNP
rs1439424833 2262 dbSNP
rs1300257860 2263 dbSNP
rs1030976176 2266 dbSNP
rs1366442019 2267 dbSNP
rs1226932561 2269 dbSNP
rs1268672630 2270 dbSNP
rs1358495150 2272 dbSNP
rs1192410320 2286 dbSNP
rs1467564296 2288 dbSNP
rs1255410454 2292 dbSNP
rs1222860812 2293 dbSNP
rs1307274526 2296 dbSNP
rs1271254478 2304 dbSNP
rs1049798544 2307 dbSNP
rs1228973594 2315 dbSNP
rs889953593 2316 dbSNP
rs1216557325 2324 dbSNP
rs1272395926 2325 dbSNP
rs778187323 2328 dbSNP
rs1302791868 2333 dbSNP
rs1438771671 2339 dbSNP
rs1368747407 2340 dbSNP
rs1041707960 2346 dbSNP
rs1248384996 2365 dbSNP
rs1464304550 2366 dbSNP
rs1190524219 2368 dbSNP
rs1369853444 2370 dbSNP
rs1472803366 2371 dbSNP
rs1162125057 2373 dbSNP
rs1167973973 2378 dbSNP
rs1431277862 2380 dbSNP
rs747587198 2391 dbSNP
rs994363186 2399 dbSNP
rs1452028924 2402 dbSNP
rs1270175005 2406 dbSNP
rs1323190756 2408 dbSNP
rs1182058321 2411 dbSNP
rs1192304265 2420 dbSNP
rs1480555888 2426 dbSNP
rs574095040 2432 dbSNP
rs1025976368 2446 dbSNP
rs771296463 2453 dbSNP
rs887436111 2472 dbSNP
rs1026744800 2475 dbSNP
rs33972462 2476 dbSNP
rs760277836 2476 dbSNP
rs951262225 2476 dbSNP
rs1006392159 2486 dbSNP
rs148181347 2497 dbSNP
rs949336036 2497 dbSNP
rs1296289780 2505 dbSNP
rs970308003 2506 dbSNP
rs558846704 2509 dbSNP
rs980734155 2509 dbSNP
rs1332832132 2510 dbSNP
rs1378868584 2531 dbSNP
rs1176110931 2546 dbSNP
rs981325583 2547 dbSNP
rs759830490 2548 dbSNP
rs955979527 2561 dbSNP
rs1461721153 2566 dbSNP
rs1349612800 2570 dbSNP
rs1184832550 2575 dbSNP
rs756510889 2576 dbSNP
rs1257150452 2578 dbSNP
rs1203168422 2589 dbSNP
rs1258088490 2592 dbSNP
rs1256696023 2596 dbSNP
rs1054250396 2600 dbSNP
rs1215131291 2609 dbSNP
rs571127457 2631 dbSNP
rs1424917348 2639 dbSNP
rs1304779811 2640 dbSNP
rs1230066824 2649 dbSNP
rs1007853821 2662 dbSNP
rs539437315 2662 dbSNP
rs746735371 2662 dbSNP
rs758398425 2662 dbSNP
rs1302968705 2671 dbSNP
rs1452389330 2673 dbSNP
rs1344013084 2675 dbSNP
rs1161981529 2679 dbSNP
rs914582067 2682 dbSNP
rs1417595268 2687 dbSNP
rs1186206177 2688 dbSNP
rs1425831740 2693 dbSNP
rs868566841 2697 dbSNP
rs947368496 2701 dbSNP
rs1186072155 2703 dbSNP
rs985965001 2709 dbSNP
rs911282424 2725 dbSNP
rs1484927176 2739 dbSNP
rs944108800 2750 dbSNP
rs1210523560 2753 dbSNP
rs186222079 2756 dbSNP
rs899467207 2757 dbSNP
rs576274712 2759 dbSNP
rs1231199164 2769 dbSNP
rs1341934114 2772 dbSNP
rs1312976806 2773 dbSNP
rs1041242173 2776 dbSNP
rs995197751 2778 dbSNP
rs1254740323 2788 dbSNP
rs1027128344 2793 dbSNP
rs1458256225 2798 dbSNP
rs376685483 2800 dbSNP
rs1163277682 2804 dbSNP
rs565270077 2810 dbSNP
rs191097862 2811 dbSNP
rs983012651 2815 dbSNP
rs930262062 2817 dbSNP
rs1250016917 2831 dbSNP
rs1189247684 2840 dbSNP
rs1453408083 2841 dbSNP
rs1465330666 2841 dbSNP
rs1157183857 2852 dbSNP
rs556149368 2865 dbSNP
rs1265747497 2871 dbSNP
rs1048593934 2875 dbSNP
rs1226244002 2880 dbSNP
rs980621505 2882 dbSNP
rs112317825 2889 dbSNP
rs34111123 2889 dbSNP
rs397993049 2889 dbSNP
rs771217078 2889 dbSNP
rs1324457397 2899 dbSNP
rs1396804028 2900 dbSNP
rs1391912440 2907 dbSNP
rs1312540513 2908 dbSNP
rs887447573 2916 dbSNP
rs778551574 2928 dbSNP
rs1392236551 2939 dbSNP
rs1169347050 2945 dbSNP
rs936644625 2947 dbSNP
rs1394462305 2950 dbSNP
rs989518783 2963 dbSNP
rs541039853 2974 dbSNP
rs913962599 2975 dbSNP
rs560783998 2979 dbSNP
rs1051932016 2983 dbSNP
rs1335095177 2992 dbSNP
rs762499750 2994 dbSNP
rs181181576 2998 dbSNP
rs763629075 2999 dbSNP
rs1345506344 3012 dbSNP
rs1003032168 3017 dbSNP
rs58339883 3023 dbSNP
rs1277779927 3024 dbSNP
rs141581839 3026 dbSNP
rs1048092222 3029 dbSNP
rs761624717 3033 dbSNP
rs886853905 3035 dbSNP
rs1249281808 3039 dbSNP
rs1352187811 3046 dbSNP
rs1308845316 3052 dbSNP
rs1418988256 3072 dbSNP
rs1373711843 3073 dbSNP
rs563465043 3074 dbSNP
rs1174348899 3087 dbSNP
rs1478979681 3094 dbSNP
rs532383295 3100 dbSNP
rs1021525969 3105 dbSNP
rs1471480383 3106 dbSNP
rs1024688032 3108 dbSNP
rs1205436176 3111 dbSNP
rs1485119202 3135 dbSNP
rs970506340 3136 dbSNP
rs969134929 3140 dbSNP
rs777533132 3160 dbSNP
rs1373874881 3161 dbSNP
rs186399744 3162 dbSNP
rs373086900 3165 dbSNP
rs1414427259 3168 dbSNP
rs989880975 3171 dbSNP
rs1336298296 3178 dbSNP
rs1395925510 3180 dbSNP
rs913943634 3181 dbSNP
rs554695744 3182 dbSNP
rs1365308882 3184 dbSNP
rs1303365489 3194 dbSNP
rs546053834 3198 dbSNP
rs1413948710 3200 dbSNP
rs1331425975 3202 dbSNP
rs1182575710 3218 dbSNP
rs976797882 3219 dbSNP
rs1474706113 3225 dbSNP
rs918764030 3226 dbSNP
rs1233314907 3228 dbSNP
rs987522192 3229 dbSNP
rs566002407 3234 dbSNP
rs911995337 3239 dbSNP
rs1300720025 3244 dbSNP
rs1269186041 3250 dbSNP
rs1233031105 3251 dbSNP
rs527651646 3272 dbSNP
rs1343848335 3274 dbSNP
rs1377295625 3274 dbSNP
rs1205497357 3282 dbSNP
rs750245971 3288 dbSNP
rs910164077 3291 dbSNP
rs1479394605 3293 dbSNP
rs1039244156 3295 dbSNP
rs920835372 3300 dbSNP
rs948285117 3301 dbSNP
rs1270121790 3312 dbSNP
rs1454934613 3325 dbSNP
rs1044107178 3330 dbSNP
rs1164646906 3336 dbSNP
rs1393722318 3337 dbSNP
rs1472882727 3346 dbSNP
rs1241046268 3349 dbSNP
rs1186065529 3354 dbSNP
rs1451533692 3355 dbSNP
rs1466675793 3367 dbSNP
rs1249155187 3372 dbSNP
rs1213531472 3374 dbSNP
rs755965429 3387 dbSNP
rs150895830 3391 dbSNP
rs1353973948 3397 dbSNP
rs372245324 3399 dbSNP
rs886741769 3403 dbSNP
rs1204470435 3404 dbSNP
rs1003847068 3413 dbSNP
rs190335842 3414 dbSNP
rs1295562062 3415 dbSNP
rs1437331974 3432 dbSNP
rs1367356385 3435 dbSNP
rs1002632006 3438 dbSNP
rs1321130665 3443 dbSNP
rs1435596996 3459 dbSNP
rs1056861049 3465 dbSNP
rs1325233942 3486 dbSNP
rs1405616026 3489 dbSNP
rs1389143657 3490 dbSNP
rs1391366231 3492 dbSNP
rs1166217050 3503 dbSNP
rs1440161271 3506 dbSNP
rs891651178 3514 dbSNP
rs1010043454 3515 dbSNP
rs1021457084 3522 dbSNP
rs1367153148 3527 dbSNP
rs968689556 3533 dbSNP
rs1248845651 3535 dbSNP
rs906313953 3535 dbSNP
rs752940706 3541 dbSNP
rs139371148 3544 dbSNP
rs770868025 3550 dbSNP
rs145532652 3558 dbSNP
rs976807886 3560 dbSNP
rs918648071 3561 dbSNP
rs951563760 3562 dbSNP
rs1302673028 3564 dbSNP
rs984276786 3570 dbSNP
rs182893605 3581 dbSNP
rs1365343632 3595 dbSNP
rs1469296430 3597 dbSNP
rs1436891890 3598 dbSNP
rs1010784584 3602 dbSNP
rs1021299906 3609 dbSNP
rs1431183488 3612 dbSNP
rs1370671467 3620 dbSNP
rs777934251 3622 dbSNP
rs1174688877 3632 dbSNP
rs1431998525 3638 dbSNP
rs1427833168 3645 dbSNP
rs1192208695 3649 dbSNP
rs1472463362 3657 dbSNP
rs1207560235 3661 dbSNP
rs538872693 3666 dbSNP
rs1251490482 3675 dbSNP
rs305112 3676 dbSNP
rs572418601 3678 dbSNP
rs1208081345 3680 dbSNP
rs987489792 3683 dbSNP
rs926978609 3684 dbSNP
rs1349665941 3685 dbSNP
rs938302133 3688 dbSNP
rs1419094059 3692 dbSNP
rs147282439 3694 dbSNP
rs554550235 3697 dbSNP
rs964820561 3698 dbSNP
rs945761565 3711 dbSNP
rs1361472909 3737 dbSNP
rs771476490 3744 dbSNP
rs187747066 3752 dbSNP
rs1410251196 3757 dbSNP
rs930812217 3759 dbSNP
rs1473068023 3760 dbSNP
rs1162750179 3761 dbSNP
rs1390515016 3766 dbSNP
rs1484269162 3767 dbSNP
rs1256602246 3768 dbSNP
rs1210766763 3778 dbSNP
rs1328329974 3794 dbSNP
rs1266068879 3795 dbSNP
rs1229969929 3799 dbSNP
rs368994980 3804 dbSNP
rs1435572524 3807 dbSNP
rs1287865556 3808 dbSNP
rs1393877641 3809 dbSNP
rs1047947882 3822 dbSNP
rs1359433034 3822 dbSNP
rs1435037314 3834 dbSNP
rs9998860 3834 dbSNP
rs1006816216 3835 dbSNP
rs1368172183 3839 dbSNP
rs1162963599 3840 dbSNP
rs1046076358 3851 dbSNP
rs906285771 3853 dbSNP
rs1187980744 3858 dbSNP
rs746290242 3860 dbSNP
rs770122481 3869 dbSNP
rs1246112580 3874 dbSNP
rs1210424174 3877 dbSNP
rs1486081911 3879 dbSNP
rs1055286090 3893 dbSNP
rs563401101 3893 dbSNP
rs1323093274 3912 dbSNP
rs200653511 3914 dbSNP
rs201215786 3915 dbSNP
rs1226984473 3926 dbSNP
rs901193098 3931 dbSNP
rs1331605539 3940 dbSNP
rs1011172221 3957 dbSNP
rs1292100349 3963 dbSNP
rs1216968315 3970 dbSNP
rs998114141 3971 dbSNP
rs1241962846 3972 dbSNP
rs1447715706 3973 dbSNP
rs1392036542 3974 dbSNP
rs1190434780 3976 dbSNP
rs1447466228 3976 dbSNP
rs1266440178 3978 dbSNP
rs1207824348 3989 dbSNP
rs1489282927 3991 dbSNP
rs1485006044 3998 dbSNP
rs1025580594 4000 dbSNP
rs532319433 4007 dbSNP
rs1339468182 4012 dbSNP
rs902456804 4013 dbSNP
rs1228833436 4019 dbSNP
rs1331009176 4023 dbSNP
rs773247230 4024 dbSNP
rs1299692692 4033 dbSNP
rs1388882930 4035 dbSNP
rs1391796476 4043 dbSNP
rs1307669254 4044 dbSNP
rs1427987249 4045 dbSNP
rs546036312 4050 dbSNP
rs1169251953 4057 dbSNP
rs1474938456 4063 dbSNP
rs1196566515 4074 dbSNP
rs559646241 4076 dbSNP
rs1269265021 4078 dbSNP
rs1181015395 4086 dbSNP
rs1481845957 4087 dbSNP
rs1276216532 4111 dbSNP
rs1195838328 4115 dbSNP
rs1345006564 4118 dbSNP
rs1254752692 4121 dbSNP
rs1018993973 4124 dbSNP
rs528390126 4126 dbSNP
rs964708337 4133 dbSNP
rs11938873 4134 dbSNP
rs1414108963 4136 dbSNP
rs1346542304 4138 dbSNP
rs769608282 4142 dbSNP
rs775690961 4143 dbSNP
rs1017109629 4144 dbSNP
rs762911448 4144 dbSNP
rs1401006051 4154 dbSNP
rs35002634 4164 dbSNP
rs762697625 4177 dbSNP
rs764120858 4179 dbSNP
rs1308760632 4189 dbSNP
rs1413977028 4198 dbSNP
rs773924148 4207 dbSNP
rs981063282 4208 dbSNP
rs1170759223 4211 dbSNP
rs1395273355 4213 dbSNP
rs1313146464 4223 dbSNP
rs928175413 4240 dbSNP
rs1354219199 4241 dbSNP
rs1412401734 4245 dbSNP
rs1291908016 4250 dbSNP
rs1181127847 4255 dbSNP
rs1429776132 4255 dbSNP
rs1471428825 4260 dbSNP
rs532467436 4261 dbSNP
rs1253517082 4263 dbSNP
rs1352866902 4263 dbSNP
rs952223186 4267 dbSNP
rs1224879371 4269 dbSNP
rs939568767 4269 dbSNP
rs548232601 4270 dbSNP
rs1267952992 4283 dbSNP
rs912901897 4288 dbSNP
rs751802991 4293 dbSNP
rs1226912408 4298 dbSNP
rs1280348112 4300 dbSNP
rs1331583247 4300 dbSNP
rs945815361 4305 dbSNP
rs1338782303 4309 dbSNP
rs1043168031 4310 dbSNP
rs544481260 4316 dbSNP
rs865888475 4318 dbSNP
rs1315546144 4333 dbSNP
rs1212454761 4338 dbSNP
rs567640698 4344 dbSNP
rs942505039 4353 dbSNP
rs1039638412 4355 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' acaauuacgaUUAUACAUCCUc 5'
                    | | ||||||| 
Target 5' ----------AUUCUGUAGGAg 3'
 		1 - 12
2 
miRNA  3' acaauuaCGAUU--A-UACAUCCUc 5'
                 |:|||  |  |||| |: 
Target 5' cugagccGUUAACUUCCUGUAAGGg 3'
 		21 - 45
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 3093.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000261427.5 | 3UTR | AUUCUGUAGGAGGGUCUAUUCUGAGCCGUUAACUUCCUGUAAGGGGAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000261427.5 | 3UTR | AUUCUGUAGGAGGGUCUAUUCUGAGCCGUUAACUUCCUGUAAGGGGAAAAUGGGUGGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE38226 Liver fibrosis -0.71 1.6e-4 -0.693 2.5e-4 21 Click to see details
GSE28260 Renal cortex and medulla 0.72 2.8e-3 0.571 2.1e-2 13 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.493 6.1e-3 0.505 5.0e-3 25 Click to see details
GSE19350 CNS germ cell tumors -0.646 1.2e-2 0.096 3.8e-1 12 Click to see details
GSE19536 Breast cancer -0.221 1.4e-2 -0.181 3.6e-2 100 Click to see details
GSE19783 ER- ER- breast cancer -0.203 3.6e-2 -0.152 9.1e-2 79 Click to see details
GSE42095 Differentiated embryonic stem cells -0.372 4.0e-2 -0.312 7.4e-2 23 Click to see details
GSE28544 Breast cancer 0.297 7.9e-2 0.328 5.9e-2 24 Click to see details
GSE19783 ER+ ER+ breast cancer -0.286 1.1e-1 -0.341 7.1e-2 20 Click to see details
GSE26953 Aortic valvular endothelial cells -0.216 1.6e-1 -0.240 1.3e-1 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.15 2.6e-1 -0.287 1.1e-1 20 Click to see details
GSE21687 Ependynoma primary tumors -0.076 2.8e-1 -0.074 2.8e-1 64 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.22 3.4e-1 0.371 2.3e-1 6 Click to see details
GSE17498 Multiple myeloma 0.049 3.8e-1 0.243 6.5e-2 40 Click to see details
GSE32688 Pancreatic cancer 0.054 3.8e-1 0.030 4.4e-1 32 Click to see details
GSE32688 Pancreatic cancer 0.054 3.8e-1 0.030 4.4e-1 32 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUSC 0.593 0 0.598 0 20 Click to see details
KIRP 0.767 0.07 0.600 0.14 5 Click to see details
LIHC 0.399 0.09 0.352 0.12 13 Click to see details
UCEC -0.692 0.1 -0.700 0.09 5 Click to see details
PRAD 0.606 0.14 0.400 0.25 5 Click to see details
STAD 0.281 0.19 0.259 0.21 12 Click to see details
PAAD 0.554 0.22 0.400 0.3 4 Click to see details
ESCA 0.528 0.24 0.000 0.5 4 Click to see details
CHOL 0.46 0.35 0.500 0.33 3 Click to see details
BRCA -0.067 0.41 0.000 0.5 15 Click to see details
KIRC 0.082 0.41 -0.018 0.48 10 Click to see details
THCA -0.048 0.41 -0.165 0.23 23 Click to see details
HNSC 0.022 0.47 -0.053 0.42 16 Click to see details
HNSC 0.022 0.47 -0.053 0.42 16 Click to see details
HNSC 0.022 0.47 -0.053 0.42 16 Click to see details
HNSC 0.022 0.47 -0.053 0.42 16 Click to see details
73 hsa-miR-155-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT005808 IRAK3 interleukin 1 receptor associated kinase 3 4 1
MIRT082844 ZNF460 zinc finger protein 460 2 4
MIRT256047 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT437787 PTEN phosphatase and tensin homolog 2 1
MIRT456168 ZDHHC6 zinc finger DHHC-type containing 6 2 2
MIRT464916 TXNIP thioredoxin interacting protein 2 4
MIRT475559 HNRNPF heterogeneous nuclear ribonucleoprotein F 2 2
MIRT499608 DNAJA1 DnaJ heat shock protein family (Hsp40) member A1 2 8
MIRT504220 MYO6 myosin VI 2 4
MIRT504256 C1orf147 chromosome 1 open reading frame 147 2 4
MIRT507642 CREBRF CREB3 regulatory factor 2 2
MIRT522858 KIAA1551 KIAA1551 2 2
MIRT527505 MYD88 myeloid differentiation primary response 88 5 2
MIRT530713 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT532851 ZNF699 zinc finger protein 699 2 2
MIRT535952 MIA3 MIA family member 3, ER export factor 2 2
MIRT539041 ATXN1L ataxin 1 like 2 4
MIRT556391 LUC7L LUC7 like 2 2
MIRT558617 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 2
MIRT559869 ATXN3 ataxin 3 2 2
MIRT569208 SHC3 SHC adaptor protein 3 2 2
MIRT573122 C18orf25 chromosome 18 open reading frame 25 2 2
MIRT575076 Ddit4 DNA-damage-inducible transcript 4 2 2
MIRT607597 ABCF3 ATP binding cassette subfamily F member 3 2 6
MIRT609386 PHEX phosphate regulating endopeptidase homolog X-linked 2 2
MIRT610550 MDN1 midasin AAA ATPase 1 2 2
MIRT612390 TCF7L2 transcription factor 7 like 2 2 2
MIRT612910 GTDC1 glycosyltransferase like domain containing 1 2 6
MIRT613314 ARL5C ADP ribosylation factor like GTPase 5C 2 2
MIRT613356 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 2 4
MIRT613541 CLMP CXADR like membrane protein 2 2
MIRT617029 SYT6 synaptotagmin 6 2 2
MIRT618044 MRVI1 murine retrovirus integration site 1 homolog 2 2
MIRT619307 KIRREL kirre like nephrin family adhesion molecule 1 2 2
MIRT623209 MTFR1L mitochondrial fission regulator 1 like 2 2
MIRT625448 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT634551 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT640740 EPB41 erythrocyte membrane protein band 4.1 2 2
MIRT640906 RAB13 RAB13, member RAS oncogene family 2 2
MIRT644025 ZNF792 zinc finger protein 792 2 2
MIRT651489 WT1 Wilms tumor 1 2 2
MIRT652037 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT669093 CDK6 cyclin dependent kinase 6 2 2
MIRT696720 WNT3 Wnt family member 3 2 2
MIRT698085 TPM1 tropomyosin 1 2 2
MIRT703284 GID4 GID complex subunit 4 homolog 2 2
MIRT707183 ARHGEF33 Rho guanine nucleotide exchange factor 33 2 2
MIRT710362 CREB5 cAMP responsive element binding protein 5 2 2
MIRT713501 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT717153 LRRC3C leucine rich repeat containing 3C 2 2
MIRT719038 ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 2 2
MIRT719489 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT720284 DPYSL3 dihydropyrimidinase like 3 2 2
MIRT732474 NLRP3 NLR family pyrin domain containing 3 2 0
MIRT732620 MS multiple sclerosis 1 0
MIRT732968 TGFBR2 transforming growth factor beta receptor 2 3 0
MIRT733063 AGTR1 angiotensin II receptor type 1 3 0
MIRT733206 ADAM10 ADAM metallopeptidase domain 10 1 0
MIRT733302 CRP C-reactive protein 2 0
MIRT734202 PDCD4 programmed cell death 4 3 0
MIRT734467 SIRT1 sirtuin 1 2 0
MIRT734701 Foxo3 forkhead box O3 1 0
MIRT734889 SP4 Sp4 transcription factor 2 0
MIRT735047 BATF basic leucine zipper ATF-like transcription factor 1 0
MIRT735048 SPI1 Spi-1 proto-oncogene 1 0
MIRT735734 PICALM phosphatidylinositol binding clathrin assembly protein 3 0
MIRT735944 TNF tumor necrosis factor 1 0
MIRT736131 MYLK myosin light chain kinase 2 0
MIRT736780 FOXP3 forkhead box P3 1 0
MIRT736781 CEBPB CCAAT/enhancer binding protein beta 1 0
MIRT736858 WEE1 WEE1 G2 checkpoint kinase 2 0
MIRT736873 TLR3 toll like receptor 3 2 0
MIRT736902 CFH complement factor H 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-155 Curcumin NULL 969516 Microarray apoE−/− mice 22253797 2012 down-regulated
miR-155 Cyclophosphamide approved 2907 Quantitative real-time PCR p53+/+ pregnant mice 20170545 2010 down-regulated
miR-155 Estrogen NULL NULL Microarray mouse uterus 20720260 2010 up-regulated
miR-155 Estrogen NULL NULL Quantitative real-time PCR mouse uterus 20720260 2010 up-regulated
miR-155 Camptothecin NULL 24360 Microarray human cancer cells 24252850 2014 down-regulated
miR-155 Cocaine NULL 446220 Quantitative real-time PCR monocyte derived dendritic cells 24391808 2014 down-regulated
miR-155 Glucose NULL 5793 Microarray endothelial cells 24394957 2014 up-regulated
miR-155 Triptolide NULL 107985 Quantitative real-time PCR peripheral blood mononuclear cells (PBMCs) of RA (rheumatoid arthritis) 24909288 2014 down-regulated
miR-155 Medpor NULL NULL Microarray osteoblast-like cells line (MG-63) 18408260 2008 up-regulated
miR-155 Lithium (Li) approved 3028194 Quantitative real-time PCR lymphoblastoid cell lines (LCLs) 19254429 2009 up-regulated
miR-155 Vorinostat (SAHA) approved 5311 Microarray A549 human non-small cell lung cancer cells 19513533 2009 down-regulated
miR-155 Bisphenol A NULL 6623 Microarray immortalized cytotrophoblast cell lines HTR-8 20417706 2010 up-regulated
miR-155 Ginsenoside Rh2 NULL 119307 Microarray human glioma cells U251 21372826 2011 down-regulated
miR-155 Aidi injection NULL NULL Microarray human breast cancer cells 21563499 2011 down-regulated
miR-155 Gemcitabine approved 60750 Quantitative real-time PCR pancreatic cancer 21738581 2011 down-regulated
miR-155 Trichostatin A (TSA) NULL 444732 Microarray apoptosis-resistant breast cancer cells 21971930 2011 up-regulated
miR-155 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-155 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer HB2 22076154 2011 down-regulated
miR-155 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer HB2 22076154 2011 up-regulated
miR-155 5-aza-2'-deoxycytidine (5-Aza-CdR) approved 451668 Microarray breast cancer SKBR3 22076154 2011 up-regulated
miR-155 Glucocorticoid NULL NULL Microarray RAW264.7 cells 22326887 2012 down-regulated
miR-155 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miR-155 Temozolomide approved 5394 Quantitative real-time PCR glioblastoma cells. 22722712 2012 up-regulated
miR-155 Glucocorticoid NULL NULL TaqMan low-density array Eosinophilic esophagitis 22815788 2012 up-regulated
miR-155 Adrenaline approved 5816 Quantitative real-time PCR colon cancer HT29 cells 23036199 2012 up-regulated
miR-155 Leptin NULL NULL Quantitative real-time PCR muscles 20800581 2010 down-regulated
miR-155 Morphine approved 5288826 Microarray human monocyte-derived macrophages (h-mdms) infection with HIV-1 20564181 2010 up-regulated
miR-155 Sinomenine NULL 5459308 Quantitative real-time PCR Colitis 24066068 2013 down-regualted
miR-155 Praziquantel approved 4891 Quantitative real-time PCR liver cell lines 25051829 2014 down-regualted
miR-155 Uric acid NULL 1175 Quantitative real-time PCR endothelial cells 23996753 2013 up-regualted
miR-155 Hydroxychloroquine approved 3652 Microarray mesangial cells 24121037 2013 down-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-155 Tripterygium wilfordii Hook F resistant tissue
hsa-mir-155 Doxorubicin 31703 NSC123127 approved resistant cell line (W1)
hsa-mir-155 Vincristine 5978 approved resistant cell line (W1)
hsa-mir-155 Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-155-3p Cisplatin 5460033 NSC119875 approved sensitive High Lung Adenocarcinoma cell line (A549)
hsa-miR-155-3p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-155-3p Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (H358, H1993)
hsa-miR-155-3p Paclitaxel 36314 NSC125973 approved sensitive Low Breast Cancer cell line (MCF-7, SKBR3, MDA-MB-231)
hsa-miR-155-3p Temozolomide 5394 NSC362856 approved resistant Low Glioblastoma cell line (A172, U87)
hsa-miR-155-3p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-155-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-155-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-155-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-155-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-155-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-155-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-155-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide sensitive cell line (Bads-200)

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