miRTarBase - #MIRT256787


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pre-miRNA Information
pre-miRNA hsa-mir-136   
Genomic Coordinates chr14: 100884702 - 100884783
Description Homo sapiens miR-136 stem-loop
Comment miR-136 was first identified by cloning studies in mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-136-3p
Sequence 49| CAUCAUCGUCUCAAAUGAGUCU |70
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
C-to-U 12 14 + 100884761 26209130 MiREDiBase
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM7823565 1 COSMIC
COSM3493816 7 COSMIC
COSM1368268 8 COSMIC
COSM7310051 10 COSMIC
COSM1368269 14 COSMIC
COSM1368270 19 COSMIC
COSM344261 20 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs147448304 2 dbSNP
rs371763274 7 dbSNP
rs775059932 8 dbSNP
rs1396077682 16 dbSNP
rs761406043 18 dbSNP
rs767143412 19 dbSNP
rs375044864 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CANX   
Synonyms CNX, IP90, P90
Description calnexin
Transcript NM_001024649   
Other Transcripts NM_001746   
Expression
Putative miRNA Targets on CANX
3'UTR of CANX
(miRNA target sites are highlighted)		 
>CANX|NM_001024649|3'UTR
   1 AACAATCTTAAGAGCTTGATCTGTGATTTCTTCTCCCTCCTCCCCTGCAAGAGTGGTCCTAGGAGAGGACCTGGCACACC
  81 TTAGGTTGACATTCAGAAAACTTCAAGACATCACCATCAGCAGGCTCCAGTTGAACACTAGTCTGTGTAACTTTAAACAT
 161 CTAGCAGTAAATACTTGCAGTTGTGATATAAAGGACCCTGTTTCTGTAGAAAAGAAAACATTTAACATAATGGTTGTGAA
 241 ATGTAACATGAAGCAAACTAACTTTTTTTTTTTTAACATCTTTGTTTTTAAAATAGAATGATAGAACTTTGCCAGTCTTT
 321 AAGATCTTGGCTTAATTTAATGTATTAATCTGTTTGTGCAAACATAATACCACCATTTAAAAATGTTAGGGAGATGAGTT
 401 GCAGTTTTTATAATAGATTTTTTTTAAAGTTTGGTATTGTAAAACATTCACACCTCTGTCCCTCAAAATTGATAATTACG
 481 TTTAAAGTGCAGTCATTTGTGGTTAGAATCTTGTTTTGTTTGCTTCCATTATTGAGTTCCTCCTAAGGAAATTGAGGAGA
 561 GGGACTGAATAGAAGCCCAAATTCATATAAAAGTTGCGTTTAAGTTGTATTAAAAATAGATATATAAGAAAAAATTCTTT
 641 CACTTGATGTTTGTTAGACCAGAAAGTGTGTGTGTTCTGTAGCTCAGTTCCCAGACAGCTTTTTAGGTAGTGGAGGAGGT
 721 GGCTTCATGTGGCACTTGGGCATTTATATTCCACTTGGGAGGGTCAGGCTGTGGCCTTCTGGAGCAGGTGGCTTGTTAAG
 801 GAATGCTAGCAGGGCATGGCACGTGAGCTCCGGAATAGATGTCTTCATCACTTCTTCCACTGTGTGTTGACACTGTTTTC
 881 CTTACCTATTTCCTCAGATCCCCAGCTTTCTCCTCTGCTATGCATTTTCTTCACAGTGCAGCTTGCAGTCCGTTGCTGAA
 961 AATGATTATAAGCCCTGCATAATGTTAAGCTTTATTGTGATTACGTGTATGTTTCTTCTTTCTTTTAAGCAGACCCATAC
1041 CTTTCCAGGGTCAAAGTACAGAATAGAATACATTGATACAAAGTACAGAAAAATACTTTGATTTTTATCCATTTCTTTTA
1121 CTCTGTGTAAAGACTTGAGAAGTCTAATTCACAGGCAAACCAATACAGAATTGACTGCAGTTGAACAGACTAGAAGTATT
1201 TGTGGGAGGAGTGACATGAAGCATGAGTTATCTGATTTTTTTTGTAGCTGCTATATATTTTAAGCCTTCATTTGCAATTC
1281 ATGTAACAGTTGTGTCATAAATTACACAATAAAGCAGTCCTGTTCAAATTTTTTTTTAACGTGGCTTGTAGAATTTTTAA
1361 AAAAGTGATCTTAGGTTTGTTTTTTCATGCGGGATGCAGATGGGTGCTATCAGAGCCTCTCCCACACCACTATAGTGTAA
1441 TAATGTTATTATTACTCTACACTGAAACGTATTCAGAGTTAGATATTATTTTAGCTTCAGTTGTTCTTTAGAGGCTTTCA
1521 AATGTACCGATGATACTGTTTCTTGCACTGAATATATAAACACTCCACAGTGTTTATATTGGGAAGATATTGGGAAGGAA
1601 ATATATTTGTAAAAGATGAAGGCTGTATCTATTTTTTTTTCTTTTTAAAGTTTGTTCACTTAAATTCTTTTGAGGATGGG
1681 ATGTATTTTTCTTGCTGTTCAGTGCTTTTTCCTTTTCATCTGTTGTTCTGTGGTCACAGTGACCTTAGCTACATAGCAGA
1761 CTTTCCCAAATGTATTGATTACAAATAAACAGTTGTTACTTAGCAAGACCTGAAAATATGTCTGCAGGTTTCTCCTTGAA
1841 GCAAATGTGTGGGATCATTGCATTTCCAGAAATCTGCCTCCTTCACCCTCCGTTGACAGTATATGTCATGCCTCACTTTC
1921 TTCTAGCTGAGCTTTAAATCATTAGAGCTTAAATTGTCAGATCGTTCATTGCCTTTCCAGGGTTATTTAGTAAAGTTTGT
2001 TGAAAACAAAAACGCCTTTTCTTGGTTCTTTTTTCAGTTATTTTGAAGGTCCAGCATCCTGATTAAATGTCTGACACATT
2081 AATGAATGACCAGCAGCAGCTTTCAGCTCTTAAAAAGACACTTATATTTTGATTTTACATGCTGGTTACCTGTTCCATTG
2161 TTGTCAAATGCCCACTCTCCATCAGATGTGTTCCTCCATTTTCTTATCCACAAAGTACTCCTCACTTTTCAATTTGTCAT
2241 GTTACTAAATGGTGTTACATTAAAGCCCTGTGTTAAGTGTCTGCTTTTGACTGAATTTCTTCATAGTAACCTTCAGTGTG
2321 TGTGTGTGACTATGTTCAATTAGTGGGTTGATCTTCGTATAATTGGCCACTATGTGAGAGTTCACTACTAGGCAGAAACT
2401 ATTATGGACAGTGAAATAATGACTTTTATCTCACCACGTGAGTTTGATGCAGTCTTTTCTGTCTAGCCCTTGCCTCTTCC
2481 TGCCCATGTGATTGCGGTGCAGTAGTTTCTGTTGTATAATAGTGTGGACAGCAGCTCAGAAAAGGAGGGAATGCTACTGA
2561 TAATTTGTAGATAATATTCTTTAAGACTTAGGGGAACCATTGAACTTTGAAATTTTTATTAGAAAATTATTTGTTCAGAA
2641 TCAGACTCCATTATTTTACATATACTTAAATACTTTAGGGGTATTTTTGAAAGTTAGCCCAGTTTTTTATGTGCTATTAA
2721 ATTTTTAGATTACATACTAAAGAAAAGTATGTACACAGAATGTAGTGCTCCTAGTTACTATTTTTTCTATTAAGAAATAG
2801 TTTAGTTCTGGTGTAAAATTTGTTTGAATGCTAAAAAAAAAAAAGCAGGACTGCATTATGGCACTTTTGCCTTGGTGGCC
2881 CACTTTCTCCATTTAAAACATTAGGATTTGTATTTTTCTGCTGCGTTTGTATGAAGACATATTTGATTGTTGTTTTCTCT
2961 TGATTTTAAAATAAAACCTCATGAGCCCTAGTAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucuGAGUAAACUCUGCUACUAc 5'
             :|||  ||   ||||||| 
Target 5' gctTTCAAATGTACCGATGATa 3'
 1514 - 1535 151.00 -9.60
2 
miRNA  3' ucUGAGUAAAC-UCUGCUACUac 5'
            |: :||||| | | |||||  
Target 5' aaATATATTTGTAAAAGATGAag 3'
 1599 - 1621 116.00 -8.40
3 
miRNA  3' ucUGAGUAAACUCUGCUACUac 5'
            |:|| ||||||  ||||:  
Target 5' aaATTCTTTTGAG--GATGGga 3'
 1662 - 1681 111.00 -11.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30151318 34 COSMIC
COSN30174756 72 COSMIC
COSN30530215 105 COSMIC
COSN28162017 131 COSMIC
COSN31484304 144 COSMIC
COSN30128410 181 COSMIC
COSN23000113 261 COSMIC
COSN27340002 275 COSMIC
COSN22246427 598 COSMIC
COSN31529224 638 COSMIC
COSN6285503 643 COSMIC
COSN22251617 776 COSMIC
COSN31564624 785 COSMIC
COSN30539939 792 COSMIC
COSN14764560 805 COSMIC
COSN31526431 863 COSMIC
COSN8492470 881 COSMIC
COSN26648464 886 COSMIC
COSN31592044 1001 COSMIC
COSN31516193 1116 COSMIC
COSN28806860 1138 COSMIC
COSN31483124 1151 COSMIC
COSN26644015 1189 COSMIC
COSN21397536 1254 COSMIC
COSN26151045 1256 COSMIC
COSN4846657 1264 COSMIC
COSN31547461 1301 COSMIC
COSN31535069 1328 COSMIC
COSN31553292 1345 COSMIC
COSN31572069 1530 COSMIC
COSN30542298 1555 COSMIC
COSN24301397 1583 COSMIC
COSN31563005 1595 COSMIC
COSN29593704 1641 COSMIC
COSN20102274 1651 COSMIC
COSN20490452 1652 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1328373866 4 dbSNP
rs1428761525 5 dbSNP
rs772806133 6 dbSNP
rs1348661098 10 dbSNP
rs762698553 11 dbSNP
rs766069353 13 dbSNP
rs372523907 19 dbSNP
rs751157767 21 dbSNP
rs200489430 23 dbSNP
rs756569666 25 dbSNP
rs1444878876 27 dbSNP
rs764334946 29 dbSNP
rs754419547 32 dbSNP
rs1455183229 34 dbSNP
rs376853046 36 dbSNP
rs181704268 40 dbSNP
rs1319360171 43 dbSNP
rs745883773 45 dbSNP
rs201943117 48 dbSNP
rs1387557194 52 dbSNP
rs369412541 59 dbSNP
rs747165153 65 dbSNP
rs944181137 72 dbSNP
rs186409621 73 dbSNP
rs1301170965 74 dbSNP
rs1370093725 85 dbSNP
rs866118322 87 dbSNP
rs901633083 92 dbSNP
rs776237617 94 dbSNP
rs1348246475 95 dbSNP
rs1355106462 99 dbSNP
rs748124474 105 dbSNP
rs1032034423 109 dbSNP
rs769785906 111 dbSNP
rs189975498 115 dbSNP
rs1189369088 116 dbSNP
rs762608998 117 dbSNP
rs1251717844 121 dbSNP
rs1433157006 122 dbSNP
rs1265289040 128 dbSNP
rs1208014256 138 dbSNP
rs765802032 141 dbSNP
rs1365976320 144 dbSNP
rs1468923584 146 dbSNP
rs1158715934 150 dbSNP
rs1395424154 162 dbSNP
rs1463097587 164 dbSNP
rs72809773 165 dbSNP
rs1011520237 166 dbSNP
rs879376573 172 dbSNP
rs1019379175 174 dbSNP
rs1309040594 179 dbSNP
rs1022862099 184 dbSNP
rs965091180 190 dbSNP
rs1320972142 200 dbSNP
rs1386749626 201 dbSNP
rs975287020 208 dbSNP
rs969889834 216 dbSNP
rs1428218161 221 dbSNP
rs1002669493 225 dbSNP
rs1466521288 234 dbSNP
rs1295001965 249 dbSNP
rs952686367 262 dbSNP
rs1267956138 263 dbSNP
rs1324485281 263 dbSNP
rs1451015095 263 dbSNP
rs397724671 263 dbSNP
rs530585026 263 dbSNP
rs984432793 263 dbSNP
rs766797346 271 dbSNP
rs1385835189 275 dbSNP
rs77294431 275 dbSNP
rs75878741 277 dbSNP
rs961517580 281 dbSNP
rs1320819662 285 dbSNP
rs973213216 296 dbSNP
rs919962315 299 dbSNP
rs918011713 305 dbSNP
rs949446019 314 dbSNP
rs1231878407 318 dbSNP
rs1299707234 325 dbSNP
rs1285758681 327 dbSNP
rs1333160810 332 dbSNP
rs1408476436 336 dbSNP
rs1370361482 345 dbSNP
rs952690544 355 dbSNP
rs1411905361 363 dbSNP
rs1288207090 364 dbSNP
rs564169084 365 dbSNP
rs1172122883 368 dbSNP
rs1478392645 369 dbSNP
rs1327165660 371 dbSNP
rs1431449800 372 dbSNP
rs1201514969 377 dbSNP
rs776200196 387 dbSNP
rs375900004 390 dbSNP
rs780805419 403 dbSNP
rs1045259381 404 dbSNP
rs1210743231 405 dbSNP
rs1250857340 406 dbSNP
rs1268837184 413 dbSNP
rs911440805 415 dbSNP
rs370981397 418 dbSNP
rs905345531 418 dbSNP
rs1488304736 426 dbSNP
rs1341719529 427 dbSNP
rs1054444207 428 dbSNP
rs181194158 435 dbSNP
rs1041250887 440 dbSNP
rs866242854 454 dbSNP
rs1227125544 457 dbSNP
rs934451957 459 dbSNP
rs1433501286 461 dbSNP
rs567394136 462 dbSNP
rs1289422976 471 dbSNP
rs1444797598 480 dbSNP
rs764606847 481 dbSNP
rs1409582280 484 dbSNP
rs900942917 518 dbSNP
rs947003756 521 dbSNP
rs1156979569 523 dbSNP
rs1455625384 528 dbSNP
rs1473531397 528 dbSNP
rs1411134156 533 dbSNP
rs1177642086 546 dbSNP
rs1471044340 547 dbSNP
rs14539 549 dbSNP
rs1159337753 557 dbSNP
rs1186428894 564 dbSNP
rs1461459967 565 dbSNP
rs1028188003 568 dbSNP
rs1206257520 579 dbSNP
rs1329137032 581 dbSNP
rs1269315900 582 dbSNP
rs905816008 586 dbSNP
rs1393067838 588 dbSNP
rs1003192490 598 dbSNP
rs528901989 599 dbSNP
rs983929435 600 dbSNP
rs1393359182 605 dbSNP
rs1318690371 620 dbSNP
rs1434464858 620 dbSNP
rs1389387516 621 dbSNP
rs149563069 624 dbSNP
rs752285763 639 dbSNP
rs896961023 641 dbSNP
rs1162403012 647 dbSNP
rs1288108927 659 dbSNP
rs536440692 663 dbSNP
rs994280465 672 dbSNP
rs1186197841 680 dbSNP
rs1026996706 686 dbSNP
rs1464052506 689 dbSNP
rs1242126806 691 dbSNP
rs1349243427 699 dbSNP
rs1230751609 700 dbSNP
rs868476341 704 dbSNP
rs866137408 705 dbSNP
rs1803234 720 dbSNP
rs1247161347 729 dbSNP
rs1361949512 737 dbSNP
rs1242908382 738 dbSNP
rs1267398853 740 dbSNP
rs1488689125 741 dbSNP
rs1018223093 743 dbSNP
rs1432857210 748 dbSNP
rs965629281 751 dbSNP
rs41285553 756 dbSNP
rs1425059514 760 dbSNP
rs369969678 769 dbSNP
rs1484023583 777 dbSNP
rs1166343538 781 dbSNP
rs527870998 783 dbSNP
rs936837897 786 dbSNP
rs552400468 791 dbSNP
rs1187731391 803 dbSNP
rs7566 805 dbSNP
rs531724836 806 dbSNP
rs1421494063 807 dbSNP
rs79607635 823 dbSNP
rs892737311 824 dbSNP
rs1204745747 825 dbSNP
rs945588012 828 dbSNP
rs1297881340 832 dbSNP
rs539324552 833 dbSNP
rs1365484313 839 dbSNP
rs558503316 845 dbSNP
rs1282564867 850 dbSNP
rs1405419928 851 dbSNP
rs1367230784 859 dbSNP
rs1305906253 861 dbSNP
rs1428745406 861 dbSNP
rs549884638 862 dbSNP
rs757110209 873 dbSNP
rs900826791 874 dbSNP
rs1428689393 879 dbSNP
rs1430957236 880 dbSNP
rs1307861159 882 dbSNP
rs1369059337 884 dbSNP
rs1423789464 885 dbSNP
rs996646185 898 dbSNP
rs1309112550 902 dbSNP
rs947114974 903 dbSNP
rs1028489578 907 dbSNP
rs144218225 914 dbSNP
rs1181885454 918 dbSNP
rs1481116681 921 dbSNP
rs1394299365 924 dbSNP
rs1213658217 930 dbSNP
rs1314940398 941 dbSNP
rs1208199823 950 dbSNP
rs1005808092 951 dbSNP
rs148801233 952 dbSNP
rs1224076827 953 dbSNP
rs938634536 964 dbSNP
rs1227921926 974 dbSNP
rs1286277518 990 dbSNP
rs961298415 997 dbSNP
rs1373707024 1002 dbSNP
rs1272261290 1005 dbSNP
rs759495964 1006 dbSNP
rs553775032 1008 dbSNP
rs1358103544 1013 dbSNP
rs1176483143 1014 dbSNP
rs1236774326 1018 dbSNP
rs1410386297 1043 dbSNP
rs1482232347 1047 dbSNP
rs1158976157 1049 dbSNP
rs1024966165 1050 dbSNP
rs749412590 1051 dbSNP
rs1183154702 1060 dbSNP
rs755249769 1061 dbSNP
rs994372412 1062 dbSNP
rs1483023068 1065 dbSNP
rs778816636 1066 dbSNP
rs980757668 1071 dbSNP
rs1027029203 1073 dbSNP
rs1325652104 1074 dbSNP
rs888565579 1085 dbSNP
rs1266174545 1103 dbSNP
rs926708777 1119 dbSNP
rs1166281092 1122 dbSNP
rs1388726681 1129 dbSNP
rs566013283 1135 dbSNP
rs6639 1138 dbSNP
rs1393968459 1144 dbSNP
rs1171734592 1145 dbSNP
rs989666816 1150 dbSNP
rs772199194 1153 dbSNP
rs914056460 1155 dbSNP
rs965736435 1156 dbSNP
rs185246993 1159 dbSNP
rs1304717040 1169 dbSNP
rs977046017 1172 dbSNP
rs879508588 1181 dbSNP
rs773705930 1182 dbSNP
rs1295616948 1186 dbSNP
rs1367113779 1195 dbSNP
rs747520242 1199 dbSNP
rs989689533 1201 dbSNP
rs1228953415 1205 dbSNP
rs915403210 1217 dbSNP
rs947146068 1232 dbSNP
rs1204519774 1236 dbSNP
rs1476170306 1236 dbSNP
rs922304184 1238 dbSNP
rs979828691 1239 dbSNP
rs1310419081 1245 dbSNP
rs932315021 1253 dbSNP
rs1049373770 1256 dbSNP
rs1315314052 1258 dbSNP
rs926962828 1281 dbSNP
rs1212113093 1297 dbSNP
rs771232263 1304 dbSNP
rs73342141 1310 dbSNP
rs1383309050 1312 dbSNP
rs1057055544 1317 dbSNP
rs1292205992 1324 dbSNP
rs183274640 1326 dbSNP
rs1014164616 1329 dbSNP
rs918460598 1332 dbSNP
rs11552423 1337 dbSNP
rs555502467 1341 dbSNP
rs564131238 1342 dbSNP
rs201052762 1349 dbSNP
rs1024177877 1354 dbSNP
rs929907592 1360 dbSNP
rs1193970394 1372 dbSNP
rs969966922 1374 dbSNP
rs1263760896 1376 dbSNP
rs1449696067 1378 dbSNP
rs12054833 1381 dbSNP
rs1292165136 1386 dbSNP
rs759072913 1391 dbSNP
rs573515559 1392 dbSNP
rs1039734679 1395 dbSNP
rs1033662613 1401 dbSNP
rs1424879234 1404 dbSNP
rs901183240 1407 dbSNP
rs958388305 1410 dbSNP
rs1328772645 1432 dbSNP
rs115376279 1433 dbSNP
rs1404830208 1434 dbSNP
rs1031000398 1437 dbSNP
rs779001986 1438 dbSNP
rs1178819405 1442 dbSNP
rs114977196 1449 dbSNP
rs186072913 1450 dbSNP
rs545971791 1456 dbSNP
rs1396028580 1462 dbSNP
rs976881362 1467 dbSNP
rs969519563 1469 dbSNP
rs762507828 1470 dbSNP
rs922856192 1481 dbSNP
rs1431722035 1489 dbSNP
rs927000096 1493 dbSNP
rs1201289600 1499 dbSNP
rs1481902248 1503 dbSNP
rs10387 1510 dbSNP
rs909534750 1514 dbSNP
rs1301823307 1516 dbSNP
rs992942401 1527 dbSNP
rs918246096 1529 dbSNP
rs1223484817 1530 dbSNP
rs542417257 1532 dbSNP
rs1285654681 1533 dbSNP
rs1036737033 1539 dbSNP
rs774532512 1539 dbSNP
rs1382695882 1547 dbSNP
rs1206353038 1549 dbSNP
rs896870406 1556 dbSNP
rs1014051618 1557 dbSNP
rs1400194429 1561 dbSNP
rs1175757571 1562 dbSNP
rs3205295 1568 dbSNP
rs1469269152 1570 dbSNP
rs1381496517 1576 dbSNP
rs531792454 1576 dbSNP
rs191672196 1587 dbSNP
rs568582434 1591 dbSNP
rs757733815 1593 dbSNP
rs529271064 1601 dbSNP
rs559502011 1605 dbSNP
rs757273948 1607 dbSNP
rs1001442098 1615 dbSNP
rs909733691 1627 dbSNP
rs1246526803 1631 dbSNP
rs1034127469 1632 dbSNP
rs1240780380 1632 dbSNP
rs200739493 1632 dbSNP
rs183513154 1633 dbSNP
rs11552425 1642 dbSNP
rs1260373076 1642 dbSNP
rs1021054430 1644 dbSNP
rs1444682096 1645 dbSNP
rs565822699 1648 dbSNP
rs976933955 1649 dbSNP
rs1408303635 1650 dbSNP
rs386695662 1650 dbSNP
rs68137334 1650 dbSNP
rs745909899 1650 dbSNP
rs1135225 1651 dbSNP
rs745562437 1651 dbSNP
rs774120287 1651 dbSNP
rs55868831 1652 dbSNP
rs1135233 1653 dbSNP
rs56396231 1654 dbSNP
rs1401531027 1655 dbSNP
rs1323086136 1683 dbSNP
rs922775449 1707 dbSNP
rs188296106 1710 dbSNP
rs112003561 1718 dbSNP
rs1039767337 1722 dbSNP
rs901294953 1727 dbSNP
rs1438263113 1733 dbSNP
rs1303527122 1734 dbSNP
rs985721244 1740 dbSNP
rs1214312047 1744 dbSNP
rs1349859990 1754 dbSNP
rs1285448848 1755 dbSNP
rs745974745 1758 dbSNP
rs1225814560 1762 dbSNP
rs1226475817 1765 dbSNP
rs998276078 1782 dbSNP
rs193007848 1787 dbSNP
rs1246912020 1792 dbSNP
rs1385113366 1798 dbSNP
rs779184219 1804 dbSNP
rs573725317 1816 dbSNP
rs892446841 1827 dbSNP
rs1011179324 1836 dbSNP
rs1350714765 1843 dbSNP
rs1318805007 1848 dbSNP
rs1363424380 1850 dbSNP
rs748387528 1850 dbSNP
rs540646681 1862 dbSNP
rs1162564881 1863 dbSNP
rs560386963 1885 dbSNP
rs577234327 1887 dbSNP
rs1002332403 1892 dbSNP
rs1035191430 1893 dbSNP
rs1450245459 1894 dbSNP
rs1046000960 1901 dbSNP
rs546041302 1902 dbSNP
rs564449987 1903 dbSNP
rs1054377244 1911 dbSNP
rs576221287 1914 dbSNP
rs377378185 1921 dbSNP
rs1414302283 1925 dbSNP
rs1361834880 1926 dbSNP
rs1470520106 1929 dbSNP
rs1259543527 1933 dbSNP
rs1214060245 1961 dbSNP
rs1362673878 1963 dbSNP
rs1162894407 1964 dbSNP
rs370879198 1965 dbSNP
rs1343447085 1970 dbSNP
rs1302266097 1974 dbSNP
rs1424951466 1981 dbSNP
rs1407280416 1992 dbSNP
rs951023892 2000 dbSNP
rs1010922403 2008 dbSNP
rs984011931 2014 dbSNP
rs758406513 2015 dbSNP
rs144960904 2016 dbSNP
rs529425881 2018 dbSNP
rs1479718912 2029 dbSNP
rs1268686167 2032 dbSNP
rs1200587511 2038 dbSNP
rs182647727 2064 dbSNP
rs147950214 2083 dbSNP
rs1249843912 2084 dbSNP
rs1335850654 2085 dbSNP
rs547473358 2090 dbSNP
rs1308179114 2091 dbSNP
rs140130673 2091 dbSNP
rs1220434146 2092 dbSNP
rs1281921796 2094 dbSNP
rs1321304668 2098 dbSNP
rs1358084897 2100 dbSNP
rs934091682 2112 dbSNP
rs1052505413 2118 dbSNP
rs1369377635 2121 dbSNP
rs892473830 2126 dbSNP
rs41285555 2133 dbSNP
rs1354643282 2134 dbSNP
rs962905426 2151 dbSNP
rs1468756479 2161 dbSNP
rs1429194899 2172 dbSNP
rs1135895 2175 dbSNP
rs1177700002 2178 dbSNP
rs1044003910 2181 dbSNP
rs1135903 2186 dbSNP
rs1203652021 2188 dbSNP
rs570004455 2195 dbSNP
rs747469601 2199 dbSNP
rs1135927 2204 dbSNP
rs918235636 2209 dbSNP
rs1135933 2211 dbSNP
rs140149869 2212 dbSNP
rs949832978 2215 dbSNP
rs186833378 2216 dbSNP
rs927159479 2219 dbSNP
rs1313761949 2224 dbSNP
rs1304545102 2225 dbSNP
rs1035622220 2240 dbSNP
rs1473921251 2242 dbSNP
rs937195317 2257 dbSNP
rs1389346156 2260 dbSNP
rs1332872552 2266 dbSNP
rs896629500 2270 dbSNP
rs1054664884 2275 dbSNP
rs112842867 2283 dbSNP
rs1404648650 2288 dbSNP
rs149884719 2292 dbSNP
rs1471221287 2303 dbSNP
rs1362466427 2305 dbSNP
rs1158804489 2311 dbSNP
rs1025359103 2315 dbSNP
rs145062176 2316 dbSNP
rs945926497 2316 dbSNP
rs1181900571 2320 dbSNP
rs1460938156 2324 dbSNP
rs529820660 2325 dbSNP
rs1170422947 2335 dbSNP
rs1204256390 2341 dbSNP
rs951056156 2343 dbSNP
rs983792658 2344 dbSNP
rs1016549410 2346 dbSNP
rs963961204 2358 dbSNP
rs1311017231 2360 dbSNP
rs376986405 2360 dbSNP
rs1029748346 2371 dbSNP
rs1315103153 2384 dbSNP
rs889834279 2391 dbSNP
rs1007072791 2400 dbSNP
rs1288721473 2402 dbSNP
rs1454630624 2405 dbSNP
rs765385174 2408 dbSNP
rs1296338824 2411 dbSNP
rs1444194219 2419 dbSNP
rs1385981839 2422 dbSNP
rs1364930477 2424 dbSNP
rs1425556790 2424 dbSNP
rs1017496079 2426 dbSNP
rs962956492 2429 dbSNP
rs1226736327 2433 dbSNP
rs1287845581 2436 dbSNP
rs1219852754 2438 dbSNP
rs1358262767 2439 dbSNP
rs1291941963 2451 dbSNP
rs1246341933 2457 dbSNP
rs552814991 2460 dbSNP
rs539407718 2469 dbSNP
rs1383217863 2471 dbSNP
rs933809517 2480 dbSNP
rs1340742147 2485 dbSNP
rs1424316552 2488 dbSNP
rs577177584 2490 dbSNP
rs144876317 2496 dbSNP
rs981477322 2497 dbSNP
rs1276629709 2498 dbSNP
rs1460542144 2500 dbSNP
rs1372528481 2510 dbSNP
rs927074140 2518 dbSNP
rs958673930 2520 dbSNP
rs1265129491 2524 dbSNP
rs913947983 2528 dbSNP
rs1197004637 2530 dbSNP
rs1490102600 2532 dbSNP
rs1269155442 2533 dbSNP
rs1211202379 2536 dbSNP
rs990020472 2554 dbSNP
rs1462671925 2557 dbSNP
rs1228841993 2558 dbSNP
rs558025689 2561 dbSNP
rs1281838351 2563 dbSNP
rs1043782253 2564 dbSNP
rs945978586 2570 dbSNP
rs576355655 2571 dbSNP
rs1325803622 2573 dbSNP
rs938281582 2577 dbSNP
rs1389850660 2578 dbSNP
rs114544285 2588 dbSNP
rs1168550303 2595 dbSNP
rs1466132813 2597 dbSNP
rs1190340099 2613 dbSNP
rs1425677546 2620 dbSNP
rs1373397401 2628 dbSNP
rs1174089762 2634 dbSNP
rs1477672988 2637 dbSNP
rs896656273 2649 dbSNP
rs923142630 2651 dbSNP
rs1200587736 2657 dbSNP
rs1435683784 2659 dbSNP
rs993642959 2664 dbSNP
rs1195859022 2665 dbSNP
rs1458665244 2667 dbSNP
rs1026897572 2668 dbSNP
rs1261830454 2671 dbSNP
rs886895178 2677 dbSNP
rs1051505277 2680 dbSNP
rs1324755157 2683 dbSNP
rs1276944927 2684 dbSNP
rs750700687 2692 dbSNP
rs140788068 2698 dbSNP
rs1007367960 2709 dbSNP
rs1449091409 2711 dbSNP
rs1403922917 2715 dbSNP
rs1038534006 2718 dbSNP
rs1436798120 2721 dbSNP
rs1425656725 2722 dbSNP
rs898661124 2739 dbSNP
rs1327350877 2740 dbSNP
rs1362857273 2743 dbSNP
rs1233187315 2745 dbSNP
rs994420377 2749 dbSNP
rs1025857102 2750 dbSNP
rs191252409 2756 dbSNP
rs1273528149 2758 dbSNP
rs1443479118 2772 dbSNP
rs1281242621 2792 dbSNP
rs972024241 2798 dbSNP
rs1002558472 2810 dbSNP
rs1280368588 2812 dbSNP
rs1242519017 2816 dbSNP
rs1204469407 2819 dbSNP
rs777048039 2821 dbSNP
rs1451884418 2825 dbSNP
rs1359657956 2826 dbSNP
rs1267572871 2829 dbSNP
rs1034410354 2832 dbSNP
rs1336008926 2832 dbSNP
rs1383909136 2833 dbSNP
rs1394033037 2833 dbSNP
rs35136597 2833 dbSNP
rs1182433188 2834 dbSNP
rs1473452972 2844 dbSNP
rs1239733230 2846 dbSNP
rs1191589354 2854 dbSNP
rs532548014 2856 dbSNP
rs1463753700 2863 dbSNP
rs1219119971 2869 dbSNP
rs770112629 2871 dbSNP
rs1291201622 2873 dbSNP
rs1029545564 2879 dbSNP
rs1246797945 2879 dbSNP
rs1381343415 2880 dbSNP
rs955386216 2886 dbSNP
rs988030075 2888 dbSNP
rs913729221 2890 dbSNP
rs1450760961 2891 dbSNP
rs559899363 2896 dbSNP
rs555900257 2904 dbSNP
rs763303909 2927 dbSNP
rs926623243 2930 dbSNP
rs1415267225 2938 dbSNP
rs762696500 2938 dbSNP
rs923196525 2939 dbSNP
rs775702526 2943 dbSNP
rs933210275 2943 dbSNP
rs533358549 2944 dbSNP
rs1489940033 2947 dbSNP
rs1268451787 2952 dbSNP
rs1222521889 2960 dbSNP
rs551847501 2963 dbSNP
rs768223128 2965 dbSNP
rs911201592 2970 dbSNP
rs937993689 2979 dbSNP
rs1212787698 2981 dbSNP
rs942834473 2992 dbSNP
rs1278681262 2997 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla -0.816 3.3e-4 -0.819 3.1e-4 13 Click to see details
GSE21032 Prostate cancer -0.267 7.3e-3 -0.208 3.0e-2 83 Click to see details
GSE21687 Ependynoma primary tumors -0.248 2.4e-2 -0.219 4.1e-2 64 Click to see details
GSE38226 Liver fibrosis 0.321 7.8e-2 0.304 9.0e-2 21 Click to see details
GSE32688 Pancreatic cancer -0.249 8.5e-2 -0.275 6.4e-2 32 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.276 1.2e-1 0.253 1.4e-1 20 Click to see details
GSE19783 ER+ ER+ breast cancer -0.247 1.5e-1 -0.191 2.1e-1 20 Click to see details
GSE26953 Aortic valvular endothelial cells 0.172 2.1e-1 0.217 1.5e-1 24 Click to see details
GSE19783 ER- ER- breast cancer 0.089 2.2e-1 0.007 4.8e-1 79 Click to see details
GSE19536 Breast cancer 0.068 2.5e-1 -0.004 4.8e-1 100 Click to see details
GSE19350 CNS germ cell tumors -0.152 3.2e-1 -0.182 2.9e-1 12 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.098 3.2e-1 0.053 4.0e-1 25 Click to see details
GSE28544 Breast cancer 0.067 3.8e-1 0.245 1.2e-1 24 Click to see details
GSE17498 Multiple myeloma 0.022 4.5e-1 -0.002 5.0e-1 40 Click to see details
GSE42095 Differentiated embryonic stem cells 0.027 4.5e-1 0.078 3.6e-1 23 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.019 4.6e-1 0.223 1.4e-1 25 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.005 5.0e-1 -0.200 3.7e-1 5 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUSC 0.349 0.02 0.429 0 38 Click to see details
KIRC 0.217 0.05 0.179 0.09 56 Click to see details
UCEC -0.356 0.07 -0.412 0.04 18 Click to see details
LUAD -0.353 0.13 -0.343 0.14 12 Click to see details
ESCA 0.364 0.14 0.336 0.16 11 Click to see details
CHOL -0.399 0.14 -0.467 0.1 9 Click to see details
HNSC 0.159 0.16 0.027 0.43 42 Click to see details
PCPG 0.87 0.16 1.000 0.5 3 Click to see details
CESC -0.583 0.3 -0.500 0.33 3 Click to see details
KICH 0.107 0.31 0.157 0.23 24 Click to see details
PAAD -0.372 0.31 -0.600 0.2 4 Click to see details
LIHC -0.061 0.34 -0.029 0.42 49 Click to see details
KIRP -0.05 0.4 0.007 0.49 30 Click to see details
PRAD -0.025 0.43 -0.034 0.41 50 Click to see details
STAD 0.025 0.45 -0.038 0.42 32 Click to see details
BLCA -0.023 0.46 -0.046 0.43 18 Click to see details
BRCA 0.005 0.48 0.020 0.43 83 Click to see details
THCA -0.003 0.49 -0.039 0.39 56 Click to see details
THCA -0.003 0.49 -0.039 0.39 56 Click to see details
THCA -0.003 0.49 -0.039 0.39 56 Click to see details
THCA -0.003 0.49 -0.039 0.39 56 Click to see details
46 hsa-miR-136-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT256787 CANX calnexin 1 1
MIRT380416 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 1 1
MIRT439175 ZRANB1 zinc finger RANBP2-type containing 1 1 1
MIRT439356 UBE3C ubiquitin protein ligase E3C 1 1
MIRT439465 TGFBR3 transforming growth factor beta receptor 3 1 1
MIRT440529 GTF2F1 general transcription factor IIF subunit 1 1 1
MIRT440635 FMN1 formin 1 1 1
MIRT440907 COPS4 COP9 signalosome subunit 4 1 1
MIRT441019 CAND1 cullin associated and neddylation dissociated 1 1 1
MIRT441061 C1orf43 chromosome 1 open reading frame 43 1 1
MIRT441174 ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 1 1
MIRT456146 RWDD2A RWD domain containing 2A 2 16
MIRT483517 PRPF38B pre-mRNA processing factor 38B 2 6
MIRT483556 STX11 syntaxin 11 2 4
MIRT495179 SOX11 SRY-box 11 2 6
MIRT495184 MUC20 mucin 20, cell surface associated 2 2
MIRT499361 MYLK myosin light chain kinase 2 8
MIRT504160 OPN5 opsin 5 2 4
MIRT523975 DVL3 dishevelled segment polarity protein 3 2 2
MIRT524343 CREBRF CREB3 regulatory factor 2 8
MIRT526865 PARP11 poly(ADP-ribose) polymerase family member 11 2 2
MIRT531887 SCN1B sodium voltage-gated channel beta subunit 1 2 2
MIRT533351 UHMK1 U2AF homology motif kinase 1 2 2
MIRT534099 SOX5 SRY-box 5 2 4
MIRT557097 HOXA9 homeobox A9 2 2
MIRT567000 KLHL28 kelch like family member 28 2 2
MIRT568215 C1orf21 chromosome 1 open reading frame 21 2 2
MIRT574254 G6PC glucose-6-phosphatase catalytic subunit 2 2
MIRT614013 PAOX polyamine oxidase 2 2
MIRT615541 PHF1 PHD finger protein 1 2 2
MIRT622485 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT623683 HOXB6 homeobox B6 2 2
MIRT630575 PLXDC2 plexin domain containing 2 2 4
MIRT642865 FAM227A family with sequence similarity 227 member A 2 2
MIRT649932 TTLL7 tubulin tyrosine ligase like 7 2 2
MIRT654531 RAB3GAP2 RAB3 GTPase activating non-catalytic protein subunit 2 2 2
MIRT656989 KDM5A lysine demethylase 5A 2 2
MIRT668527 ERP44 endoplasmic reticulum protein 44 2 2
MIRT693411 NUDT16 nudix hydrolase 16 2 2
MIRT700692 POLR3D RNA polymerase III subunit D 2 2
MIRT712284 PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2 2
MIRT717286 TRAF1 TNF receptor associated factor 1 2 2
MIRT724396 IQGAP1 IQ motif containing GTPase activating protein 1 2 2
MIRT725201 PTRF caveolae associated protein 1 2 2
MIRT731933 NOTCH3 notch 3 2 1
MIRT756476 BMPR1B bone morphogenetic protein receptor type 1B 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-136 Lithium (Li) approved 3028194 Microarray rat hippocampus 18704095 2009 up-regulated
miR-136 Valproate approved 3121 Microarray rat hippocampus 18704095 2009 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-136-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer tissue
hsa-miR-136-3p Imatinib 5291 NSC743414 approved sensitive Low Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-136-3p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-136-3p Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-136-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-136-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-136-3p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-136-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (RPMI2650)
hsa-miR-136-3p Sunitinib 5329102 NSC750690 approved sensitive tissue (CardB)
hsa-miR-136-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (K562)
hsa-miR-136-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-136-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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