miRTarBase - #MIRT256997


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pre-miRNA Information
pre-miRNA hsa-mir-4436b-1   
Genomic Coordinates chr2: 110086433 - 110086523
Description Homo sapiens miR-4436b-1 stem-loop
Comment None
RNA Secondary Structure
pre-miRNA hsa-mir-4436b-2   
Genomic Coordinates chr2: 110284853 - 110284943
Description Homo sapiens miR-4436b-2 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4436b-3p
Sequence 60| CAGGGCAGGAAGAAGUGGACAA |81
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760150076 9 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol RGMB   
Synonyms DRAGON
Description repulsive guidance molecule family member b
Transcript NM_001012761   
Expression
Putative miRNA Targets on RGMB
3'UTR of RGMB
(miRNA target sites are highlighted)		 
>RGMB|NM_001012761|3'UTR
   1 GGGTTGTCTTTTGTTTTGGTTTTTTATTTTTTGTCTATAACAAAATTTTAAAATATATATTGTCATAATATATTGAGTAA
  81 AAGAGTATATATGTATATACCATGTATATGACAGGATGTTTGTCCTGGGACACCCACCAGATTGTACATACTGTGTTTGG
 161 CTGTTTTCACATATGTTGGATGTAGTGTTCTTTGATTGTATCAATTTTGTTTTGCAGTTCTGTGAAATGTTTTATAATGT
 241 CCCTGCCCAGGGACCTGTTAGAAAGCACTTTATTTTTTATATATTAAATATTTATGTGTGTGCTTGGTTGATATGTATAG
 321 TACATATACACAGACATCCATATGCAGCGTTTCCTTTGAAGGTGACCAGTTGTTTGTAGCTATTCTTGGCTGTACCTTCC
 401 TGCCCTTTCCCATTGCTACTGATTTGCCACGGTGTGCAGCTTTTACTCGCCACCTTCCGGTGGAGCTGCCTCGTTCCTTT
 481 GAACTATGCCCTCACCCTTCTGCCCTCACTTGATTTGAAAGGGTCGTTAACTCTCCCTTACAGGTGCTTTGACTCTTAAA
 561 CGCTGATCTTAAGAAGCTCTCTTCATCTAAGAGCTGTTACTTTTTCAGAAGGGGGGGTATTATTGGTATTCTGATTACTC
 641 TCAATTCTAATTGTTATATATTTGAGCCCATACAGTGTATTAGGTTGAACCATAGAAACTGCTATTCTCGTAGGTCAAAA
 721 GGGTCTAGTGATGGAAGTTTTGTAGATAAGTACCAGGCATCTCAGTAACTCCTAGACTTTTTCTCATCCCATGCCCCGTT
 801 TTAAATTGTCAGTTTTCCCTCTGACTCTTCTGTGTTAAAACATGAAACTATAAATTTAGTAATTATCATGCCTTGCTCTT
 881 TTTAATCTATATGACTGATGCAAGCCCCTCTTCTTAACCGTTTCTTGGCTTTGAGCCCAGAAACACAGCTCTCCCTGTCT
 961 CCAACTCCAGTAAGCCCTCCTCAGCCTCACCTTACGAATCCAAAGAACTGGGGTTTGTTAGGTTCTTTCTCTAATGTAGA
1041 GGCCCAGATCCCATCACAAAGTTTTTCATTCTTCCTTGTCCACCATGATCTTCATCACAGTCTTTGATATGTCTGCATGC
1121 AAAGTGGAACAGAGTTGGGCGGCAATGACAGAAGAGCTTCCTTGGCCTGACTCGGTGTGCGGCCACTTCGGCACTGCTTA
1201 ATCCAGATATTCTTGTTAACTAAGCATTGTGCTTCCCAGGTGGTCTGAAGTCAGGTACTCTCTCTCTCAACACCTGTAGT
1281 TGAATATGATTTGGTCAGTTGCTCGTTGTAACTTGGAGAAATTCCTATAAAGTAAGATCTCCTTGCCTCTTCCATCCATT
1361 GTTGGCACCCCCTTGCAAAAGGAAAAGAACAGCAAAAGTCAGGAGCAGTAATCTGAGAAAGTTAACTCCAGGATAGGTAG
1441 GTTTCTATTGTTATAGCTAGATGTAAATCTTTAGTTCCAAGAAGTGATAGAGTTTCTGCTTTAATAATTTGTTGATAAGT
1521 TTACATAAACAGAAATAAAAGATACTATCTTTACCGTAGTAGTTCAGGCCAAGATTATGCTTAGTTTTAGTTCTCCAGGT
1601 AGTTACTTTTGCCATGTCCTATTGATCAGTGACACTGCCAGAGGCCCATACCGGCAAGAGGAAGAGGACGTCATTTTGTA
1681 AAGTTTAACTTCTTAGCGAACTGATGTGCCACCCAGTCACAGAGTGGAGTTGTGAATTCATGTAGAGGTGGCAAACCTCT
1761 ACCTTGTGTTGATGAGAGAATAATCTTGGGCAGTCTGGGAAAATAAGGAAGGCATCTCCTTCTTACTCATGGAGATTCAA
1841 CTATAGAGAGTTGAAACCTAAACCCGCCTTCCTTTTATAGAAGCTGGACTAGAGACGGACTGACCATCAGCTCTGAACTG
1921 TGGCTTTTTTTGTTCACCTATGATGCCATGTACCAAATTCAGAAGCTATCGTTAATAATTTGTTTTATAATTGAGTAGTA
2001 CAAGCGAGGAAAAAATACGGAGGATAACCACTATTTTTGTGCAAATAATATGAAAGTGAAGTAAAAGCAATAGAAGAAAT
2081 TTCTATAGGATCTGGGTTTAGAGTGTGTATCATTAATAAATATACCTTTGCTCTTTTCAGGGAAAATAACAACCACCCTT
2161 ACTGATAGTTGGGAAAAGAAGATTGGGTTATTTTGCCATATCATTTAGCTGGAAGTGACATTTAAAAGCACCCTGCATCA
2241 CTAGTAATAGTGTATTTTGCTATTCTGCCCTTGTAATCGGTGTCCCTGTAAAACAATCCCCACAGATTACTTTCAGAAAT
2321 AGATGTATTTCTCTACGTAAGGGCCAGGTTTATTTTCTCCTTTTTTGAGATTTCTAGAAAAAATGCTGCTTGCACATGTT
2401 GGTTCTTGAAACCTTAGCTAGAAGAATTTCAGGTCATACCAACATGTGGATAGGCTATAGCTGTTCAGAGGTCTCCTGGG
2481 GGAGCTTAAAACGGGGGAAACACTGGTTTTCACAGATGCTCCACATGGCTGTCTTTAAAAGACTCAAAACTTTTTTTTGT
2561 CCTCTTTGTTATGCTTGGAAGCTCCCCCCCCCCCAACAGTGTGTCGAGTCTTTGCAAAGAAACCTTTAGATGTGGTTCAT
2641 AGATATATGAATACGTATCTGTGTAAAACAGTGAGTGTGCAGTGTGTAAATACTTTAAATTATTATGCTAGAAAAATAAA
2721 GTTACATACCTTGCTGTGGAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aaCAGGUGAAGAAGGACGGGAc 5'
            | |:::  ||||||||||| 
Target 5' ttGGCTGTACCTTCCTGCCCTt 3'
 386 - 407 164.00 -21.00
2 
miRNA  3' aaCAGGUGAA--GA-AGGACGGGAc 5'
            || :|:||  || |:||||||| 
Target 5' taGTGTATTTTGCTATTCTGCCCTt 3'
 2248 - 2272 162.00 -18.20
3 
miRNA  3' aaCAGGUGAAGAAGGACGGGAc 5'
            | || |  | |:||||||| 
Target 5' atGCCCTCACCCTTCTGCCCTc 3'
 486 - 507 156.00 -16.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN23605089 20 COSMIC
COSN31520145 20 COSMIC
COSN31581095 220 COSMIC
COSN8397310 433 COSMIC
COSN5615149 487 COSMIC
COSN28211146 547 COSMIC
COSN20190772 661 COSMIC
COSN21649916 688 COSMIC
COSN30438928 748 COSMIC
COSN2128294 1530 COSMIC
COSN26412440 1756 COSMIC
COSN21767145 1941 COSMIC
COSN32189388 2179 COSMIC
COSN28201217 2471 COSMIC
COSN20101576 2594 COSMIC
COSN20101574 2595 COSMIC
COSN20101575 2595 COSMIC
COSN28201618 2596 COSMIC
COSN20101577 2597 COSMIC
COSN22810226 2720 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1336181731 3 dbSNP
rs374126370 4 dbSNP
rs773238301 9 dbSNP
rs181203218 11 dbSNP
rs778229891 17 dbSNP
rs1157947140 20 dbSNP
rs770124301 20 dbSNP
rs776540043 20 dbSNP
rs771848947 23 dbSNP
rs1340578863 26 dbSNP
rs1203855850 33 dbSNP
rs1406195749 34 dbSNP
rs907756949 35 dbSNP
rs940515510 36 dbSNP
rs370247358 38 dbSNP
rs1217320276 39 dbSNP
rs1308872458 41 dbSNP
rs1256039336 42 dbSNP
rs1317489095 43 dbSNP
rs746781531 46 dbSNP
rs1269069031 47 dbSNP
rs1040204060 49 dbSNP
rs542585819 51 dbSNP
rs1348723062 53 dbSNP
rs1286057777 54 dbSNP
rs901610164 57 dbSNP
rs996309560 64 dbSNP
rs1437088384 65 dbSNP
rs1459119014 65 dbSNP
rs1389122147 67 dbSNP
rs1319567329 76 dbSNP
rs146731310 88 dbSNP
rs1391923658 90 dbSNP
rs769548535 92 dbSNP
rs1029652523 94 dbSNP
rs1415451423 96 dbSNP
rs186410341 111 dbSNP
rs1319172593 112 dbSNP
rs1367939025 117 dbSNP
rs746954669 118 dbSNP
rs1312072699 119 dbSNP
rs911295432 123 dbSNP
rs1249039910 139 dbSNP
rs1208453081 145 dbSNP
rs1320209333 149 dbSNP
rs1247262425 150 dbSNP
rs770695817 159 dbSNP
rs936179231 174 dbSNP
rs190051169 175 dbSNP
rs140328145 180 dbSNP
rs1206543797 188 dbSNP
rs1365793623 191 dbSNP
rs1249864434 192 dbSNP
rs1296630879 192 dbSNP
rs1033227094 194 dbSNP
rs946248997 198 dbSNP
rs956256353 200 dbSNP
rs1010373044 205 dbSNP
rs1180844615 211 dbSNP
rs1046009675 214 dbSNP
rs143727345 227 dbSNP
rs181470223 228 dbSNP
rs1165070364 233 dbSNP
rs1410720716 237 dbSNP
rs1391271150 238 dbSNP
rs971536017 239 dbSNP
rs116849365 246 dbSNP
rs1248734307 252 dbSNP
rs927356059 270 dbSNP
rs536129685 274 dbSNP
rs1289729279 279 dbSNP
rs1207325741 281 dbSNP
rs894866937 282 dbSNP
rs1342847145 284 dbSNP
rs1391549940 296 dbSNP
rs1273784186 297 dbSNP
rs952031259 301 dbSNP
rs1005817564 302 dbSNP
rs759430398 307 dbSNP
rs1038172412 308 dbSNP
rs907808292 312 dbSNP
rs896984484 315 dbSNP
rs940564519 318 dbSNP
rs975963431 319 dbSNP
rs1436453321 325 dbSNP
rs1371790649 328 dbSNP
rs994084153 328 dbSNP
rs1168498004 334 dbSNP
rs138115694 335 dbSNP
rs923083029 335 dbSNP
rs1173488496 341 dbSNP
rs1477837733 342 dbSNP
rs1267015380 344 dbSNP
rs931781868 345 dbSNP
rs1483419172 348 dbSNP
rs1251059054 350 dbSNP
rs1202368485 362 dbSNP
rs1397807793 365 dbSNP
rs1279104641 368 dbSNP
rs548087211 370 dbSNP
rs903573382 370 dbSNP
rs1289832334 372 dbSNP
rs1409967534 374 dbSNP
rs1434073146 376 dbSNP
rs765879766 377 dbSNP
rs936347652 378 dbSNP
rs1295880199 380 dbSNP
rs1313739955 381 dbSNP
rs1440694326 386 dbSNP
rs1052020588 391 dbSNP
rs566498606 397 dbSNP
rs1469587015 400 dbSNP
rs1427541821 405 dbSNP
rs1161625766 406 dbSNP
rs1473006013 407 dbSNP
rs878944033 411 dbSNP
rs1226398013 420 dbSNP
rs116329104 425 dbSNP
rs1237961709 430 dbSNP
rs2036691 431 dbSNP
rs570511542 432 dbSNP
rs1201293093 433 dbSNP
rs1228630205 440 dbSNP
rs1006861737 449 dbSNP
rs78736744 450 dbSNP
rs1034858302 459 dbSNP
rs7705786 460 dbSNP
rs114120408 474 dbSNP
rs1181907876 487 dbSNP
rs1322889060 487 dbSNP
rs574495175 489 dbSNP
rs1471400268 496 dbSNP
rs1344779357 498 dbSNP
rs1180550949 504 dbSNP
rs967539362 511 dbSNP
rs1414521635 514 dbSNP
rs1182927641 521 dbSNP
rs372998731 523 dbSNP
rs1249696065 526 dbSNP
rs148111535 527 dbSNP
rs1464200558 531 dbSNP
rs923166205 533 dbSNP
rs939027983 536 dbSNP
rs1245885727 538 dbSNP
rs762998161 543 dbSNP
rs931810098 554 dbSNP
rs1176000570 556 dbSNP
rs1357888813 562 dbSNP
rs1054776896 563 dbSNP
rs541387362 571 dbSNP
rs1361572778 580 dbSNP
rs140962826 586 dbSNP
rs985947768 588 dbSNP
rs764180218 589 dbSNP
rs1162966088 595 dbSNP
rs916319281 597 dbSNP
rs1422694340 599 dbSNP
rs1391928591 609 dbSNP
rs568388610 611 dbSNP
rs925046384 611 dbSNP
rs1192579768 612 dbSNP
rs941152023 613 dbSNP
rs1264377993 615 dbSNP
rs148285047 618 dbSNP
rs936399861 618 dbSNP
rs572515674 620 dbSNP
rs1038081022 624 dbSNP
rs1229690856 627 dbSNP
rs1307300177 628 dbSNP
rs1293799649 634 dbSNP
rs892124499 652 dbSNP
rs1368516161 654 dbSNP
rs1302688858 657 dbSNP
rs1403153164 658 dbSNP
rs186446754 659 dbSNP
rs564554916 662 dbSNP
rs1169132747 664 dbSNP
rs993948144 672 dbSNP
rs752063016 673 dbSNP
rs1218389566 676 dbSNP
rs1050978043 686 dbSNP
rs1177913763 688 dbSNP
rs1433430774 694 dbSNP
rs1267705704 703 dbSNP
rs1276468909 705 dbSNP
rs1313863655 708 dbSNP
rs531833234 710 dbSNP
rs543548440 711 dbSNP
rs191023267 719 dbSNP
rs1034494815 722 dbSNP
rs1339261471 726 dbSNP
rs957594724 732 dbSNP
rs529250548 743 dbSNP
rs548050231 744 dbSNP
rs566773839 751 dbSNP
rs1011703195 757 dbSNP
rs1282884317 758 dbSNP
rs762242716 770 dbSNP
rs1006294786 773 dbSNP
rs1014964791 778 dbSNP
rs962033526 786 dbSNP
rs1190947118 787 dbSNP
rs376443512 789 dbSNP
rs527623562 791 dbSNP
rs1020365383 798 dbSNP
rs1435413142 799 dbSNP
rs953291684 802 dbSNP
rs1473331308 806 dbSNP
rs986385548 813 dbSNP
rs1437811169 819 dbSNP
rs1307479850 820 dbSNP
rs925105451 822 dbSNP
rs957818964 825 dbSNP
rs987847629 825 dbSNP
rs1262849737 829 dbSNP
rs140395292 829 dbSNP
rs552326166 831 dbSNP
rs1310120760 839 dbSNP
rs967568430 842 dbSNP
rs1238390360 843 dbSNP
rs1333948415 851 dbSNP
rs1314765960 852 dbSNP
rs1396447595 869 dbSNP
rs570596242 872 dbSNP
rs1334404495 880 dbSNP
rs779353710 890 dbSNP
rs1435557428 902 dbSNP
rs1157526752 904 dbSNP
rs150194182 921 dbSNP
rs1190241461 922 dbSNP
rs1445701140 932 dbSNP
rs1242949376 934 dbSNP
rs113331866 940 dbSNP
rs375189989 943 dbSNP
rs1056001939 965 dbSNP
rs1204696736 966 dbSNP
rs1348612904 967 dbSNP
rs992142603 972 dbSNP
rs73151473 978 dbSNP
rs1285470549 992 dbSNP
rs535460489 997 dbSNP
rs941005837 999 dbSNP
rs1274959813 1000 dbSNP
rs1365564134 1010 dbSNP
rs1450665619 1014 dbSNP
rs1398539329 1016 dbSNP
rs1392271727 1017 dbSNP
rs1038113490 1035 dbSNP
rs1425866946 1049 dbSNP
rs918304594 1050 dbSNP
rs1385130511 1054 dbSNP
rs1182171684 1059 dbSNP
rs929826946 1068 dbSNP
rs1451712749 1074 dbSNP
rs1245340670 1076 dbSNP
rs780084696 1076 dbSNP
rs747152145 1077 dbSNP
rs1445427495 1078 dbSNP
rs891043088 1084 dbSNP
rs77780461 1085 dbSNP
rs1358695649 1089 dbSNP
rs1289500042 1095 dbSNP
rs1040025432 1102 dbSNP
rs748101819 1103 dbSNP
rs1269312899 1105 dbSNP
rs893162440 1108 dbSNP
rs1332412660 1111 dbSNP
rs1390053941 1111 dbSNP
rs112763743 1113 dbSNP
rs1303280320 1116 dbSNP
rs1403760276 1118 dbSNP
rs1365575617 1119 dbSNP
rs1389342230 1132 dbSNP
rs182442075 1135 dbSNP
rs1030307594 1141 dbSNP
rs1420674540 1142 dbSNP
rs772203054 1144 dbSNP
rs1474578101 1151 dbSNP
rs1420561617 1159 dbSNP
rs953441494 1168 dbSNP
rs1321749611 1174 dbSNP
rs1011981628 1175 dbSNP
rs1007470442 1176 dbSNP
rs1032176889 1181 dbSNP
rs3179904 1182 dbSNP
rs1346730470 1189 dbSNP
rs1283519007 1190 dbSNP
rs778690857 1191 dbSNP
rs987901725 1195 dbSNP
rs1445029549 1196 dbSNP
rs1355604587 1197 dbSNP
rs1328651466 1198 dbSNP
rs903244406 1204 dbSNP
rs1230040107 1208 dbSNP
rs558318889 1211 dbSNP
rs1427598997 1213 dbSNP
rs1270260030 1218 dbSNP
rs185882726 1221 dbSNP
rs1480195940 1224 dbSNP
rs913669316 1227 dbSNP
rs1184380948 1230 dbSNP
rs1470497957 1237 dbSNP
rs1232199391 1243 dbSNP
rs1202263393 1252 dbSNP
rs543462755 1256 dbSNP
rs746872239 1258 dbSNP
rs753367830 1258 dbSNP
rs970482236 1258 dbSNP
rs982210465 1258 dbSNP
rs1256652686 1262 dbSNP
rs1289703292 1263 dbSNP
rs1223823889 1271 dbSNP
rs1035827316 1274 dbSNP
rs1226271004 1278 dbSNP
rs1440576873 1281 dbSNP
rs566991482 1287 dbSNP
rs959123564 1300 dbSNP
rs1291519556 1305 dbSNP
rs937622715 1306 dbSNP
rs1404149975 1309 dbSNP
rs1056052776 1310 dbSNP
rs909422300 1330 dbSNP
rs991779044 1337 dbSNP
rs1016915565 1338 dbSNP
rs1214670324 1344 dbSNP
rs962418012 1346 dbSNP
rs973684887 1359 dbSNP
rs1473697816 1362 dbSNP
rs561866940 1364 dbSNP
rs111539695 1369 dbSNP
rs1459734567 1376 dbSNP
rs997591179 1378 dbSNP
rs376172170 1382 dbSNP
rs889121710 1382 dbSNP
rs559515427 1383 dbSNP
rs527580768 1385 dbSNP
rs1472477992 1393 dbSNP
rs147530587 1395 dbSNP
rs1039656204 1402 dbSNP
rs1452329519 1421 dbSNP
rs957922286 1431 dbSNP
rs893016136 1435 dbSNP
rs1416182474 1436 dbSNP
rs1454446725 1436 dbSNP
rs1461805907 1437 dbSNP
rs1344689910 1442 dbSNP
rs570580027 1442 dbSNP
rs1156959930 1446 dbSNP
rs531558753 1448 dbSNP
rs2662257 1450 dbSNP
rs549869521 1455 dbSNP
rs1386436704 1461 dbSNP
rs970914135 1461 dbSNP
rs1249604541 1465 dbSNP
rs1186749473 1467 dbSNP
rs1437185433 1468 dbSNP
rs981874251 1469 dbSNP
rs1239886403 1473 dbSNP
rs1223104948 1489 dbSNP
rs539099414 1489 dbSNP
rs1196700712 1492 dbSNP
rs568147675 1493 dbSNP
rs191527576 1495 dbSNP
rs1041702435 1497 dbSNP
rs547369176 1500 dbSNP
rs1339388843 1506 dbSNP
rs1002996833 1511 dbSNP
rs2617508 1512 dbSNP
rs1285634512 1513 dbSNP
rs942235901 1517 dbSNP
rs972248565 1520 dbSNP
rs894672242 1523 dbSNP
rs1361470563 1525 dbSNP
rs1013471933 1526 dbSNP
rs1234344604 1527 dbSNP
rs1406841669 1527 dbSNP
rs919419693 1531 dbSNP
rs1422599995 1533 dbSNP
rs540082378 1541 dbSNP
rs1170824722 1542 dbSNP
rs1374617925 1542 dbSNP
rs374033611 1543 dbSNP
rs1201037646 1546 dbSNP
rs933441039 1548 dbSNP
rs963922422 1549 dbSNP
rs1285521948 1550 dbSNP
rs558167481 1556 dbSNP
rs1489990858 1557 dbSNP
rs1253470041 1563 dbSNP
rs1228586232 1571 dbSNP
rs1185473425 1576 dbSNP
rs1307175436 1581 dbSNP
rs943387170 1589 dbSNP
rs770673319 1591 dbSNP
rs1025296460 1597 dbSNP
rs951049978 1600 dbSNP
rs73151474 1602 dbSNP
rs1409493713 1604 dbSNP
rs1302586968 1606 dbSNP
rs1298580579 1607 dbSNP
rs1458573142 1607 dbSNP
rs912287416 1612 dbSNP
rs1352456647 1615 dbSNP
rs1401370701 1617 dbSNP
rs183081577 1622 dbSNP
rs1335601819 1626 dbSNP
rs1355766665 1627 dbSNP
rs975629389 1628 dbSNP
rs914497872 1634 dbSNP
rs555573956 1635 dbSNP
rs947253907 1636 dbSNP
rs1480519539 1648 dbSNP
rs188115827 1652 dbSNP
rs924629288 1653 dbSNP
rs938650357 1654 dbSNP
rs1003746094 1655 dbSNP
rs192118374 1665 dbSNP
rs1282786129 1668 dbSNP
rs959081439 1670 dbSNP
rs983806938 1671 dbSNP
rs1016590120 1673 dbSNP
rs767110906 1674 dbSNP
rs963651992 1677 dbSNP
rs1431053599 1678 dbSNP
rs1344900404 1685 dbSNP
rs746904610 1689 dbSNP
rs1013086542 1696 dbSNP
rs775088170 1698 dbSNP
rs1454890176 1699 dbSNP
rs1363812427 1703 dbSNP
rs762437648 1710 dbSNP
rs1183170790 1715 dbSNP
rs933511899 1717 dbSNP
rs1282561323 1718 dbSNP
rs1486002415 1721 dbSNP
rs1461969881 1722 dbSNP
rs1038238434 1724 dbSNP
rs1262751028 1737 dbSNP
rs753328075 1741 dbSNP
rs62367692 1742 dbSNP
rs1026508153 1744 dbSNP
rs951081037 1747 dbSNP
rs1333857286 1749 dbSNP
rs1473473027 1751 dbSNP
rs1453058343 1755 dbSNP
rs1007823350 1757 dbSNP
rs1377056856 1758 dbSNP
rs945333466 1762 dbSNP
rs1019380619 1763 dbSNP
rs1157434022 1766 dbSNP
rs758678914 1772 dbSNP
rs975282133 1773 dbSNP
rs1042309370 1774 dbSNP
rs906406468 1777 dbSNP
rs1242853443 1801 dbSNP
rs1428481869 1804 dbSNP
rs781253700 1805 dbSNP
rs1448913924 1813 dbSNP
rs1204607170 1818 dbSNP
rs1351469340 1819 dbSNP
rs576807235 1819 dbSNP
rs1246515812 1828 dbSNP
rs1358471672 1832 dbSNP
rs1282171543 1833 dbSNP
rs376187426 1835 dbSNP
rs1326629084 1841 dbSNP
rs894920034 1845 dbSNP
rs766694134 1848 dbSNP
rs961035494 1859 dbSNP
rs968520598 1866 dbSNP
rs146862505 1867 dbSNP
rs182886326 1870 dbSNP
rs924493495 1871 dbSNP
rs751751887 1881 dbSNP
rs938681829 1884 dbSNP
rs1057431093 1885 dbSNP
rs1231718076 1892 dbSNP
rs577962326 1893 dbSNP
rs2662256 1894 dbSNP
rs781272594 1897 dbSNP
rs1490151714 1898 dbSNP
rs564240894 1898 dbSNP
rs1272812695 1904 dbSNP
rs1216073171 1916 dbSNP
rs748186986 1926 dbSNP
rs993615463 1935 dbSNP
rs1047982691 1938 dbSNP
rs554557776 1941 dbSNP
rs138500581 1942 dbSNP
rs890687347 1946 dbSNP
rs945384425 1949 dbSNP
rs535896145 1954 dbSNP
rs1349790090 1961 dbSNP
rs1322035762 1971 dbSNP
rs1411997411 1971 dbSNP
rs3841392 1973 dbSNP
rs187923499 1982 dbSNP
rs1019664849 1988 dbSNP
rs1167570384 1993 dbSNP
rs556017111 1994 dbSNP
rs963740472 1999 dbSNP
rs997040367 2002 dbSNP
rs528991683 2007 dbSNP
rs1206430815 2015 dbSNP
rs1244902828 2015 dbSNP
rs1021370380 2018 dbSNP
rs1438192762 2019 dbSNP
rs117069948 2020 dbSNP
rs1196408846 2027 dbSNP
rs565621000 2032 dbSNP
rs1325188834 2034 dbSNP
rs1462177041 2044 dbSNP
rs13541 2049 dbSNP
rs1367604093 2055 dbSNP
rs749172088 2059 dbSNP
rs1385405863 2060 dbSNP
rs1328565937 2063 dbSNP
rs1444921562 2065 dbSNP
rs1336755564 2072 dbSNP
rs1372335855 2072 dbSNP
rs1464307031 2077 dbSNP
rs374140881 2086 dbSNP
rs192440433 2088 dbSNP
rs1408530764 2089 dbSNP
rs201702768 2095 dbSNP
rs1469340509 2097 dbSNP
rs376164178 2114 dbSNP
rs1178880518 2118 dbSNP
rs1423075781 2118 dbSNP
rs992749026 2121 dbSNP
rs1470451305 2123 dbSNP
rs915934722 2124 dbSNP
rs1176525552 2127 dbSNP
rs1005351055 2134 dbSNP
rs948729218 2146 dbSNP
rs896879482 2147 dbSNP
rs768740453 2148 dbSNP
rs993867184 2148 dbSNP
rs1029725925 2151 dbSNP
rs770599437 2154 dbSNP
rs973925352 2155 dbSNP
rs920652580 2156 dbSNP
rs929496473 2169 dbSNP
rs955014400 2180 dbSNP
rs1009557512 2182 dbSNP
rs1017769562 2184 dbSNP
rs1047849059 2188 dbSNP
rs890715468 2199 dbSNP
rs1215304697 2200 dbSNP
rs1385330692 2205 dbSNP
rs1337650397 2209 dbSNP
rs1447483514 2215 dbSNP
rs944988277 2217 dbSNP
rs1161322606 2219 dbSNP
rs1401269096 2220 dbSNP
rs1379583561 2224 dbSNP
rs1039286373 2238 dbSNP
rs899525056 2242 dbSNP
rs989572895 2244 dbSNP
rs1243465845 2245 dbSNP
rs1182603216 2263 dbSNP
rs996496544 2275 dbSNP
rs537374835 2279 dbSNP
rs1263226423 2280 dbSNP
rs184595451 2287 dbSNP
rs1215842785 2291 dbSNP
rs904234318 2295 dbSNP
rs1366318220 2297 dbSNP
rs998693807 2300 dbSNP
rs1238532156 2309 dbSNP
rs978140438 2312 dbSNP
rs75097821 2316 dbSNP
rs959895601 2317 dbSNP
rs189265167 2319 dbSNP
rs1055044802 2320 dbSNP
rs1290754398 2321 dbSNP
rs1431569147 2324 dbSNP
rs1359889539 2332 dbSNP
rs553213768 2334 dbSNP
rs1296281902 2335 dbSNP
rs576547030 2337 dbSNP
rs1435014007 2338 dbSNP
rs1319059235 2339 dbSNP
rs1163779054 2347 dbSNP
rs1421729249 2352 dbSNP
rs1421197319 2360 dbSNP
rs771806297 2377 dbSNP
rs1382805513 2379 dbSNP
rs1186656072 2384 dbSNP
rs1312332139 2393 dbSNP
rs970478176 2395 dbSNP
rs973354711 2396 dbSNP
rs920685128 2397 dbSNP
rs1215120114 2398 dbSNP
rs1273579068 2415 dbSNP
rs1293025178 2415 dbSNP
rs774477566 2420 dbSNP
rs1320216112 2424 dbSNP
rs2545680 2427 dbSNP
rs1215327887 2432 dbSNP
rs545059759 2437 dbSNP
rs1339944230 2440 dbSNP
rs1262369054 2448 dbSNP
rs1276341733 2448 dbSNP
rs1038187172 2452 dbSNP
rs1485927204 2453 dbSNP
rs896932388 2453 dbSNP
rs1292794311 2456 dbSNP
rs1180748568 2458 dbSNP
rs994312101 2471 dbSNP
rs1253714210 2472 dbSNP
rs760209082 2481 dbSNP
rs1475980191 2485 dbSNP
rs890786445 2488 dbSNP
rs1481731213 2493 dbSNP
rs1188138613 2496 dbSNP
rs1268665956 2497 dbSNP
rs1191041000 2498 dbSNP
rs768059035 2498 dbSNP
rs1253380785 2504 dbSNP
rs1205529807 2520 dbSNP
rs1317469800 2522 dbSNP
rs1006520446 2524 dbSNP
rs1225424746 2525 dbSNP
rs1346136474 2528 dbSNP
rs1017818449 2537 dbSNP
rs1384936570 2537 dbSNP
rs1419044640 2537 dbSNP
rs912101328 2544 dbSNP
rs1298480542 2551 dbSNP
rs1464820370 2552 dbSNP
rs1456997406 2559 dbSNP
rs1157589066 2560 dbSNP
rs1347428735 2562 dbSNP
rs1454420440 2563 dbSNP
rs1175985319 2565 dbSNP
rs1376518849 2565 dbSNP
rs1469859105 2565 dbSNP
rs768654408 2567 dbSNP
rs1302325118 2569 dbSNP
rs1253131697 2570 dbSNP
rs1179616556 2571 dbSNP
rs1400419756 2572 dbSNP
rs562174753 2573 dbSNP
rs1345809608 2576 dbSNP
rs1255446358 2582 dbSNP
rs1346399726 2582 dbSNP
rs1294072218 2583 dbSNP
rs1338313439 2583 dbSNP
rs1439484747 2584 dbSNP
rs35759358 2584 dbSNP
rs866468190 2584 dbSNP
rs879210593 2584 dbSNP
rs1349676924 2587 dbSNP
rs796168896 2588 dbSNP
rs1022400967 2589 dbSNP
rs966847738 2589 dbSNP
rs1039705839 2590 dbSNP
rs978574166 2590 dbSNP
rs563703035 2591 dbSNP
rs960999489 2591 dbSNP
rs576403431 2592 dbSNP
rs918410263 2592 dbSNP
rs941241155 2592 dbSNP
rs1042710452 2593 dbSNP
rs1051292197 2593 dbSNP
rs1161688536 2593 dbSNP
rs1463686080 2594 dbSNP
rs1491151476 2594 dbSNP
rs765898043 2594 dbSNP
rs904179001 2594 dbSNP
rs368747777 2595 dbSNP
rs60547205 2595 dbSNP
rs797000821 2595 dbSNP
rs998642994 2595 dbSNP
rs1053451 2596 dbSNP
rs1287421004 2596 dbSNP
rs1309391581 2597 dbSNP
rs200404031 2597 dbSNP
rs1339173707 2598 dbSNP
rs1226303752 2599 dbSNP
rs1309111886 2615 dbSNP
rs1011099632 2616 dbSNP
rs1022452827 2620 dbSNP
rs1330923015 2628 dbSNP
rs1208894691 2630 dbSNP
rs1253743568 2632 dbSNP
rs1321934839 2633 dbSNP
rs1486332191 2634 dbSNP
rs371229624 2636 dbSNP
rs1401266033 2637 dbSNP
rs895666984 2638 dbSNP
rs1035527987 2640 dbSNP
rs1464143135 2641 dbSNP
rs1431451646 2643 dbSNP
rs960798798 2644 dbSNP
rs990843897 2647 dbSNP
rs1014061908 2655 dbSNP
rs1023323878 2656 dbSNP
rs1175830265 2657 dbSNP
rs969963652 2666 dbSNP
rs1183676570 2668 dbSNP
rs1457985981 2669 dbSNP
rs1237171669 2670 dbSNP
rs962655204 2670 dbSNP
rs1420202999 2671 dbSNP
rs1325081705 2676 dbSNP
rs1278671605 2682 dbSNP
rs1220338846 2687 dbSNP
rs1344897352 2687 dbSNP
rs1175899010 2691 dbSNP
rs758390289 2695 dbSNP
rs575935803 2699 dbSNP
rs1378033083 2702 dbSNP
rs1330936837 2706 dbSNP
rs918473553 2709 dbSNP
rs1360989814 2714 dbSNP
rs929809089 2718 dbSNP
rs994807959 2718 dbSNP
rs1413875504 2721 dbSNP
rs986620065 2728 dbSNP
rs1160141274 2729 dbSNP
rs1027646047 2737 dbSNP
rs1436610719 2738 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aacagGUGAAGAAGGACGGGAc 5'
               :||  ||||||||||| 
Target 5' -----UAC--CUUCCUGCCCUu 3'
 		1 - 15
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_001012761 | 3UTR | AUGCAGCGUUUCCUUUGAAGGUGACCAGUUGUUUGUAGCUAUUCUUGGCUGUACCUUCCUGCCCUUUCCCAUUGCUACUGAUUUGCCACGGUGUGCAGCUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000308234.7 | 3UTR | UACCUUCCUGCCCUUUCCCAUUGCUACUGAUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
87 hsa-miR-4436b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066957 ATXN7L3B ataxin 7 like 3B 2 8
MIRT119284 NABP1 nucleic acid binding protein 1 2 6
MIRT128915 KMT2A lysine methyltransferase 2A 2 2
MIRT150116 MIDN midnolin 2 2
MIRT173040 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT253117 BCL2L12 BCL2 like 12 2 2
MIRT256997 RGMB repulsive guidance molecule family member b 2 2
MIRT259746 SNX12 sorting nexin 12 2 2
MIRT267278 TMEM109 transmembrane protein 109 2 2
MIRT441934 C1orf109 chromosome 1 open reading frame 109 2 2
MIRT443625 CPSF2 cleavage and polyadenylation specific factor 2 2 2
MIRT445757 AGO1 argonaute 1, RISC catalytic component 2 2
MIRT447835 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT451230 ZNF444 zinc finger protein 444 2 2
MIRT451966 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT453127 HOXC4 homeobox C4 2 2
MIRT454604 RPL13A ribosomal protein L13a 2 2
MIRT455176 SUV39H1 suppressor of variegation 3-9 homolog 1 2 2
MIRT455547 GJB1 gap junction protein beta 1 2 2
MIRT458197 ATP6V0A2 ATPase H+ transporting V0 subunit a2 2 2
MIRT458356 NOC2L NOC2 like nucleolar associated transcriptional repressor 2 2
MIRT458923 DNM2 dynamin 2 2 2
MIRT461013 SYT7 synaptotagmin 7 2 2
MIRT461643 ZSWIM4 zinc finger SWIM-type containing 4 2 2
MIRT461997 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT462367 BCL7B BCL tumor suppressor 7B 2 2
MIRT464915 TXNIP thioredoxin interacting protein 2 2
MIRT466311 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT466591 TBC1D2B TBC1 domain family member 2B 2 2
MIRT467045 SRSF1 serine and arginine rich splicing factor 1 2 2
MIRT468750 SDC2 syndecan 2 2 2
MIRT468943 RPS24 ribosomal protein S24 2 2
MIRT469474 REEP5 receptor accessory protein 5 2 2
MIRT469913 PTRF caveolae associated protein 1 2 2
MIRT473325 MEX3A mex-3 RNA binding family member A 2 2
MIRT473643 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT474064 LMNB2 lamin B2 2 2
MIRT474357 KMT2D lysine methyltransferase 2D 2 2
MIRT475394 ICMT isoprenylcysteine carboxyl methyltransferase 2 4
MIRT476335 GLTSCR1L BRD4 interacting chromatin remodeling complex associated protein like 2 2
MIRT478651 CTDNEP1 CTD nuclear envelope phosphatase 1 2 2
MIRT479585 CDC42SE1 CDC42 small effector 1 2 2
MIRT479943 CBX5 chromobox 5 2 2
MIRT482001 AMOTL2 angiomotin like 2 2 2
MIRT482043 AMER1 APC membrane recruitment protein 1 2 2
MIRT483070 EXT2 exostosin glycosyltransferase 2 2 6
MIRT484323 KCNH1 potassium voltage-gated channel subfamily H member 1 2 4
MIRT487528 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT489636 ALS2CL ALS2 C-terminal like 2 2
MIRT490693 SSTR1 somatostatin receptor 1 2 2
MIRT490871 UPK2 uroplakin 2 2 2
MIRT492582 PPM1L protein phosphatase, Mg2+/Mn2+ dependent 1L 2 2
MIRT492945 NEUROD2 neuronal differentiation 2 2 2
MIRT498675 SOD2 superoxide dismutase 2 2 4
MIRT499349 RAB25 RAB25, member RAS oncogene family 2 2
MIRT502338 GIGYF1 GRB10 interacting GYF protein 1 2 4
MIRT502976 CCNL1 cyclin L1 2 8
MIRT503706 NUP62 nucleoporin 62 2 2
MIRT505567 SMUG1 single-strand-selective monofunctional uracil-DNA glycosylase 1 2 2
MIRT507808 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT513242 FBXO41 F-box protein 41 2 6
MIRT513586 EVX1 even-skipped homeobox 1 2 2
MIRT525036 FRK fyn related Src family tyrosine kinase 2 2
MIRT531035 TDGF1P3 teratocarcinoma-derived growth factor 1 pseudogene 3 2 2
MIRT531939 RBMS2 RNA binding motif single stranded interacting protein 2 2 2
MIRT534912 PUM2 pumilio RNA binding family member 2 2 2
MIRT535717 N4BP1 NEDD4 binding protein 1 2 2
MIRT540498 ZMAT4 zinc finger matrin-type 4 2 4
MIRT541465 AURKA aurora kinase A 2 2
MIRT554328 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT561572 SLC6A9 solute carrier family 6 member 9 2 2
MIRT564715 ZNF322P1 zinc finger protein 322 pseudogene 1 2 2
MIRT576176 Hmox1 heme oxygenase 1 2 2
MIRT629712 XKR4 XK related 4 2 2
MIRT636182 THBD thrombomodulin 2 2
MIRT646315 MPHOSPH8 M-phase phosphoprotein 8 2 2
MIRT649174 IQSEC1 IQ motif and Sec7 domain 1 2 2
MIRT666945 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT684057 FOLR1 folate receptor 1 2 2
MIRT687585 MAU2 MAU2 sister chromatid cohesion factor 2 2
MIRT689953 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT704071 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT704327 DCUN1D5 defective in cullin neddylation 1 domain containing 5 2 2
MIRT705406 ATP1B3 ATPase Na+/K+ transporting subunit beta 3 2 2
MIRT710488 CDH5 cadherin 5 2 2
MIRT718241 LCE1A late cornified envelope 1A 2 2
MIRT723182 CDCA4 cell division cycle associated 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4436b-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4436b-3p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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