miRTarBase - #MIRT263248


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pre-miRNA Information
pre-miRNA hsa-mir-4271   
Genomic Coordinates chr3: 49274120 - 49274186
Description Homo sapiens miR-4271 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4271
Sequence 39| GGGGGAAGAAAAGGUGGGG |57
Evidence Experimental
Experiments SOLiD
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN30481495 1 COSMIC
COSN31532060 5 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs760829741 1 dbSNP
rs1277951968 2 dbSNP
rs189148716 3 dbSNP
rs757021935 4 dbSNP
rs1285201145 6 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SGPL1   
Synonyms NPHS14, S1PL, SPL
Description sphingosine-1-phosphate lyase 1
Transcript NM_003901   
Expression
Putative miRNA Targets on SGPL1
3'UTR of SGPL1
(miRNA target sites are highlighted)		 
>SGPL1|NM_003901|3'UTR
   1 ACTTGGACCCTTTCTAGTCTCAAGGGGATTCCAGCCTTCAGAAGGTTCTTGGGATATGGAACAGGCCGTGCACAACTTTG
  81 ACATCTGGTCTTGCTCCATAGAGCACAACTCAAGATAGACCATGAGACAGCTTGAGCCTCAGGATTCTTGTTCTTCCTCT
 161 TATCTTCCTTTTGTGGTTTTTAATTTGAAGACCCCAGAGAATTCCATTACATAATGATTTTGCCCTTGTTATAAATGTTA
 241 CCCTAGGAATTGTTTTAACCATTTCCTTTTCTAAACTCTCTAGCTTTCAACTTTACTTAAACATTGTGTGGTAGCTCTGA
 321 CCTGTCCTGATTCTTTAGAGAAGCTGGGGTACAGTTTATGAGATAGCTAGAGCTTCTTTGTTATCTCAGGCAGGAGGCGT
 401 TTACATAACAGATGTTTCCTCAGCTGGGTGTGAGGTATACTCTAAGCAGGAGGCTTTTTCAGCCTTCTCTCTCTTTTTTT
 481 TTTTTTTTTTTTTTTTTGAGATGGAATTTTGCTCTTTTGCCCAGTCTGGAGTGCAGTGGCATGATCTCAGCTCACTGCAA
 561 CCTCCACCCACTGGGTTCAAGCGATTCTTCTGCCTCAGCCTCCCGAGTAGCTGGGATTACCGGCACCCACCACCACGCCT
 641 GGCTAATTTTTCAATTTTCTTTTTCAGTAGAGACGGGTTCACCGTGTTGGCCAGGCTGGTCTTGAACTCCTGACCTCAGG
 721 TGATACCCGCCCCCCCGCCTCAGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCTGGCCCTGTCTCTCTT
 801 AAGAGTAGGTTCATTGTCTGTCTTAGAGTCACTTCTATTGCAACTCATTTTCTTTTTCCAGGGCACAGATCGACCAAGCT
 881 GCCGTTCCCTATTCTGCAGGACAGGACTATTCTAGCATACCTGCTTCGTCCACCCAGGCAGGGTTTGGGGTGGTCTCTTC
 961 TGTGCCTGCAGTCCCCATTTGACACTTGGTTGCCACCATCTTTGGAGATTATTGTTTGGAATGATGCTTCCATTGGCTTT
1041 TTCTTGTTACCATGGACTAGGAAGAAAACATGGTTTCCAAATAATCTGGGAGCTTTTGGCCATGGTGCCGCCTTCCTGAA
1121 TTGGCAGTGGTCAGAGCACACCTGAACCCTATCCTGGGCTGGTGATGAGCAGAAATCAGACCTTTTTCTATGCTTTTTTG
1201 AATATCAGAGTAGGATGAACACCCAGATTCAAATATGTCACCAAAGTTGGTGGTGGTCCTTCCCTGCACCCTTGCGTTAA
1281 GCCATTATGTAATGAAAATGTGTTTGCTTGAAGGAACAGCTCAAAGCACCTTCACAAGTTGCCTTGACTTACCCTAGGTG
1361 GGTGTGAAAGAGCACCCGTAGCAAGGAAAATTTTCTCTATTAGTGTGTTCTTCTGCCTCTTCCCCCTTGATTCAGCTTTC
1441 AGAGGTACTATGGCAGTTTTGCCTCAGGTGCTGAACATTTCTCAGCCCTGGCTAAAAGGGAGCAGCACAGGGAGAGAAAC
1521 AGGATAGGAAAGCAGAATGGCGAGCAGCCTATGGCCCAGGGCCTGTAATCCCTTCCCAAGACTAGCTGCTCAGGGTGGTG
1601 CAGGGACAGGACCAGACCCTGCGCCTATTTCCTGCCTTCTTTCCCCTATAGGGAACTCTGTAGGCTGAGCCACTGTCCTG
1681 CTCTTATGACATTATATCTTGTGCCTTTCTCCTCAGCAGTGAGCAGTGAGCTACTCCTGGCCCAGGCCCTAGGGGAAATG
1761 GATCAGTCTTTGAGGTTTCTATTTGGGGAGGGGAGTACTTAAGATGAGTCAAAAGACACTTTCCTCTGTTCCATTCCCCA
1841 TCTCAGGGACTCCTGAATATTCAGCCTCTCCAGGCTGGTGTCTTCTAGTTTCCCCCACTGGGAATGCTGGCTGGGAGAGC
1921 CATGACTACCAGACTTTTCCTCAGGCTCCTTGGCATGTTAGTCTGAATTGTTCTTGAGCACTGTACTACTGACCCAACAA
2001 CTGTGACTAGCTGGCCACGCCATTCAGGGCTGGTGTGGCATTTATGTGTGTGTGTGTGTGTGTGTGTGTTTTTCCTGTTT
2081 GCCCAGCAGTGCATTGTGGGTTCCAAGAGTGGGTAGTGTGTGTATGTGTGTGTGTCAGAGGGAGACCTGGCAGGCACCTC
2161 TTTGAGAGTAGCTGTGGTCAGAGCTGTTTGGTCAGTGCATTATGTTGAATGAGGTCCAGGAACCCAGAGCCACCCAGCAG
2241 ACACCACTGTGGCTTGCCAGCTGCCAAGATGGAGAAGCATGTGCCCCTGTAGAGCGTCTCCCCAGAACCAGACCCCGAGC
2321 CACTCGCTTCCTCTGTGCTGTGACAACATTGGTGCCAGGGGAGATGGTGTTTTTCAAAGGGACCTACTGTAGCCACTTTA
2401 ATTTACAATTAAGAGCCTTAGTTTGACTTAACACTTTTGTAGGCTTTTCATTGTGTATTTTTGTGTATGTGTGCATATAG
2481 CAGCTACTCTGTAGCAGAGGTGGGTAGAGACACTTAATAGTATCATGTCGCATGCAGATGTCACATCGGCCTCTGCAAAA
2561 ACTGTACTGTCTTGTTTCTGCATTAGACTTAAGTAGTCATGTGAATATACTGCTATGTCACTTTTAATATTACGAGTTTT
2641 ATACTTGGAAAATGGTACTTGCTTCTTTTAAATCTCTGTCTTCTCTAACCTCCCCCTTCCCATTTCAATGCTCCCTTCCT
2721 AATTTCAGCAATAATCTCAAAAAGCAATTAAATAGTTAAATGACCCTAATTGTAATTACTGTGGATGGTTGCATTCATTT
2801 GATTACTTGGGCACACACGAGATGACAAATGGGGCAGTGGCCATGCTTGAATGGGCTCCTGGTGAGAGATTGCCCCCTGG
2881 TGGTGAAACAATCGTGTGTGCCCACTGATACCAAGACCAATGAAAGAGACACAGTTAAGCAGCAATCCATCTCATTTCCA
2961 GGCACTTCAATAGGTCGCTGATTGGTCCTTGCACCAGCAGTGGTAGTCGTACCTATTTCAGAGAGGTCTGAAATTCAGGT
3041 TCTTAGTTTGCCAGGGACAGGCCCTATCTTATATTTTTTTCCATCTTCATCATCCACTTCTGCTTACAGTTTGCTGCTTA
3121 CAATAACTTAATGATGGATTGAGTTATCTGGGTGGTCTCTAGCCATCTGGGCAGTGTGGTTCTGTCTAACCAAAGGGCAT
3201 TGGCCTCAAACCCTGCATTTGGTTTAGGGGCTAACAGAGCTCCTCAGATAATCTTCACACACATGTAACTGCTGGAGATC
3281 TTATTCTATTATGAATAAGAAACGAGAAGTTTTTCCAAAGTGTTAGTCAGGATCTGAAGGCTGTCATTCAGATAACCCAG
3361 CTTTTCCTTTTGGCTTTTAGCCCATTCAGACTTTGCCAGAGTCAAGCCAAGGATTGCTTTTTTGCTACAGTTTTCTGCCA
3441 AATGGCCTAGTTCCTGAGTACCTGGAAACCAGAGAGAAAGAGGATCCAGGATGTACTTGGATGAGGAGGCCTGGCTTATC
3521 TAGGAAGTCGTGTCTGGGGTGCTTATTGCTGCTCCATACAGCTGTACGTCAGCCCCTTGGCCTTCTCTGTAGGTTCTTGG
3601 CAGCAATGAGCAGCTTTCACTCAGTGACACAAGTAATTACTGAGTCCTAATTTGATAGCCACCAACTGTACCTGGGTAGG
3681 CAAAGTCAGATTTTTGAGAACCTTTTTCCTGATTTGAAGTTTTAATTACCTTATTTTCTTTTATGCTTTCCTCTGTCTTG
3761 TAATCTTTTCTCTTCTTAATATCCTTCCCTATAATTTCAATTATTTGGATTAATTTTAGAATAAACCTATTTATTTCTAA
3841 AAAAAAAAAGAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ggGGUGGAAAAGAAGGGGg 5'
            |::||   |||||||| 
Target 5' ttCTGCC---TCTTCCCCc 3'
 1411 - 1426 150.00 -20.60
2 
miRNA  3' gggguGGAAAAGAAGGGGg 5'
               |:| |||||||:| 
Target 5' ggattCTTGTTCTTCCTCt 3'
 142 - 160 142.00 -13.50
3 
miRNA  3' ggGGUGGAAAAGAAGGGGg 5'
            |::||  |||||:||| 
Target 5' tcCTGCC--TTCTTTCCCc 3'
 1630 - 1646 141.00 -22.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN1122025 28 COSMIC
COSN30508474 40 COSMIC
COSN8935637 45 COSMIC
COSN30504180 69 COSMIC
COSN31564426 70 COSMIC
COSN30161718 82 COSMIC
COSN31581858 93 COSMIC
COSN28196207 114 COSMIC
COSN30164801 165 COSMIC
COSN195129 257 COSMIC
COSN32128657 515 COSMIC
COSN24075085 612 COSMIC
COSN16354899 741 COSMIC
COSN31567731 1628 COSMIC
COSN31544821 1749 COSMIC
COSN31542496 1775 COSMIC
COSN24551468 1875 COSMIC
COSN20107238 2069 COSMIC
COSN15159193 2296 COSMIC
COSN29374066 2393 COSMIC
COSN29207942 2478 COSMIC
COSN28676099 2530 COSMIC
COSN7067576 2541 COSMIC
COSN31486411 2579 COSMIC
COSN31601210 2686 COSMIC
COSN31547989 2745 COSMIC
COSN31555000 2841 COSMIC
COSN7067577 3272 COSMIC
COSN24783582 3344 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs555707122 3 dbSNP
rs1356380207 6 dbSNP
rs1242402326 7 dbSNP
rs1238597773 8 dbSNP
rs768734116 10 dbSNP
rs1402137026 19 dbSNP
rs978081638 23 dbSNP
rs762525603 24 dbSNP
rs142181612 46 dbSNP
rs774045941 49 dbSNP
rs1281458462 55 dbSNP
rs936787373 57 dbSNP
rs746950533 68 dbSNP
rs770869453 69 dbSNP
rs751439714 70 dbSNP
rs1362324177 73 dbSNP
rs1261845497 74 dbSNP
rs1430224727 83 dbSNP
rs77332227 85 dbSNP
rs544160855 87 dbSNP
rs1192193151 89 dbSNP
rs1255115788 98 dbSNP
rs556194771 102 dbSNP
rs759390988 114 dbSNP
rs906788433 125 dbSNP
rs560177505 129 dbSNP
rs1412014405 133 dbSNP
rs1004529680 158 dbSNP
rs575988164 163 dbSNP
rs767108590 164 dbSNP
rs1036050362 190 dbSNP
rs774093714 193 dbSNP
rs1185605573 194 dbSNP
rs765049507 196 dbSNP
rs1010320746 197 dbSNP
rs1188096031 197 dbSNP
rs898905016 206 dbSNP
rs995022038 207 dbSNP
rs1307889534 210 dbSNP
rs1402555417 213 dbSNP
rs113187186 233 dbSNP
rs1159717382 247 dbSNP
rs1028816098 253 dbSNP
rs968864061 256 dbSNP
rs61851618 262 dbSNP
rs1295339791 263 dbSNP
rs1459675047 267 dbSNP
rs1354839088 276 dbSNP
rs545632843 277 dbSNP
rs185095842 281 dbSNP
rs1463945964 286 dbSNP
rs1327739233 291 dbSNP
rs1029055499 306 dbSNP
rs1008732686 309 dbSNP
rs1408542958 310 dbSNP
rs762639199 315 dbSNP
rs1165121571 318 dbSNP
rs189947374 323 dbSNP
rs1254721407 325 dbSNP
rs978049178 329 dbSNP
rs1178898738 333 dbSNP
rs907771981 338 dbSNP
rs1440941336 339 dbSNP
rs550218133 345 dbSNP
rs1232199477 346 dbSNP
rs1202259905 348 dbSNP
rs562091113 350 dbSNP
rs958146314 355 dbSNP
rs973612392 364 dbSNP
rs1234061645 365 dbSNP
rs1223898851 366 dbSNP
rs920474644 374 dbSNP
rs1310606123 380 dbSNP
rs1393192592 385 dbSNP
rs529288062 386 dbSNP
rs1298099651 390 dbSNP
rs916678730 394 dbSNP
rs927284885 400 dbSNP
rs948181265 408 dbSNP
rs982297209 415 dbSNP
rs1415179017 416 dbSNP
rs1160705051 420 dbSNP
rs938660136 423 dbSNP
rs1175355239 425 dbSNP
rs1469193045 431 dbSNP
rs1469656983 433 dbSNP
rs1253355872 434 dbSNP
rs928174193 438 dbSNP
rs940952893 439 dbSNP
rs1468244771 443 dbSNP
rs1263872495 447 dbSNP
rs181252334 453 dbSNP
rs1231416882 464 dbSNP
rs1317533906 466 dbSNP
rs1306920849 467 dbSNP
rs1238557742 470 dbSNP
rs1471183273 470 dbSNP
rs372331289 471 dbSNP
rs892012291 471 dbSNP
rs1177923810 472 dbSNP
rs1290250345 472 dbSNP
rs1388212043 472 dbSNP
rs1440585081 472 dbSNP
rs865995037 472 dbSNP
rs117751078 474 dbSNP
rs1214511097 474 dbSNP
rs1234086411 474 dbSNP
rs1260167325 474 dbSNP
rs1265605183 474 dbSNP
rs1297286427 474 dbSNP
rs1304799058 474 dbSNP
rs1329650843 474 dbSNP
rs1344028465 474 dbSNP
rs1350728698 474 dbSNP
rs1360692066 474 dbSNP
rs1382401842 474 dbSNP
rs1486252789 474 dbSNP
rs1491344373 474 dbSNP
rs1295866101 475 dbSNP
rs1491476086 475 dbSNP
rs12249840 476 dbSNP
rs930332921 477 dbSNP
rs1050557465 478 dbSNP
rs1374543997 479 dbSNP
rs1394899028 490 dbSNP
rs1219331942 498 dbSNP
rs1429388676 498 dbSNP
rs869092070 498 dbSNP
rs1191679056 499 dbSNP
rs1445639706 499 dbSNP
rs1326416200 500 dbSNP
rs1355955511 501 dbSNP
rs1442290176 506 dbSNP
rs1311804371 509 dbSNP
rs1353034984 510 dbSNP
rs1231925556 511 dbSNP
rs1486684507 512 dbSNP
rs1295685403 513 dbSNP
rs1335847031 515 dbSNP
rs1214392314 520 dbSNP
rs888888019 522 dbSNP
rs1439836914 524 dbSNP
rs1043612321 529 dbSNP
rs1343355622 531 dbSNP
rs1205507791 534 dbSNP
rs904711725 536 dbSNP
rs996313098 539 dbSNP
rs1484752528 547 dbSNP
rs1416152629 548 dbSNP
rs1189923022 551 dbSNP
rs1009116491 552 dbSNP
rs1355478584 554 dbSNP
rs1018762074 555 dbSNP
rs555219452 556 dbSNP
rs1394166688 557 dbSNP
rs1418552299 558 dbSNP
rs1474940519 568 dbSNP
rs903089708 576 dbSNP
rs566242568 581 dbSNP
rs184729436 583 dbSNP
rs958244712 584 dbSNP
rs989500512 599 dbSNP
rs1172630239 603 dbSNP
rs1008531097 604 dbSNP
rs1416111208 606 dbSNP
rs1315324028 607 dbSNP
rs1341661499 614 dbSNP
rs868233814 622 dbSNP
rs1268728396 623 dbSNP
rs969514150 627 dbSNP
rs1229366074 631 dbSNP
rs147404261 635 dbSNP
rs570228817 637 dbSNP
rs1241944922 638 dbSNP
rs188175381 639 dbSNP
rs1329437326 642 dbSNP
rs940922258 643 dbSNP
rs920404786 648 dbSNP
rs116881201 655 dbSNP
rs567753765 675 dbSNP
rs1188179493 676 dbSNP
rs930280160 679 dbSNP
rs1190949270 684 dbSNP
rs1243563937 685 dbSNP
rs1366119822 698 dbSNP
rs180747387 701 dbSNP
rs1183094415 726 dbSNP
rs1475635692 726 dbSNP
rs938774922 727 dbSNP
rs1050107672 729 dbSNP
rs1288694010 730 dbSNP
rs762116533 730 dbSNP
rs888848890 730 dbSNP
rs913272875 731 dbSNP
rs1352142354 732 dbSNP
rs944482499 735 dbSNP
rs1040180310 736 dbSNP
rs1441328140 737 dbSNP
rs1403692352 738 dbSNP
rs903058550 738 dbSNP
rs946270802 752 dbSNP
rs1043340427 754 dbSNP
rs554037319 770 dbSNP
rs1378969685 771 dbSNP
rs55659308 780 dbSNP
rs1032852286 781 dbSNP
rs754079617 799 dbSNP
rs1218833003 810 dbSNP
rs532986399 811 dbSNP
rs142298691 815 dbSNP
rs1284294207 823 dbSNP
rs1215237711 829 dbSNP
rs1351474480 830 dbSNP
rs1302918924 833 dbSNP
rs755184474 838 dbSNP
rs1236564916 851 dbSNP
rs1369901581 864 dbSNP
rs1008687985 865 dbSNP
rs1023667565 866 dbSNP
rs778898424 872 dbSNP
rs1003671315 873 dbSNP
rs1035108377 877 dbSNP
rs962162507 879 dbSNP
rs1419165403 880 dbSNP
rs1359248503 883 dbSNP
rs76223172 884 dbSNP
rs920814066 885 dbSNP
rs952358037 888 dbSNP
rs1465162988 889 dbSNP
rs75182629 891 dbSNP
rs1192391133 894 dbSNP
rs1250740727 897 dbSNP
rs748235301 898 dbSNP
rs1211424494 901 dbSNP
rs758353507 915 dbSNP
rs145452290 918 dbSNP
rs1311423807 921 dbSNP
rs1455260605 929 dbSNP
rs969712818 934 dbSNP
rs1341813998 942 dbSNP
rs980539332 946 dbSNP
rs1399488630 953 dbSNP
rs927834143 954 dbSNP
rs1193886257 978 dbSNP
rs147685895 984 dbSNP
rs1468178404 994 dbSNP
rs992895222 1001 dbSNP
rs1174449930 1002 dbSNP
rs913220637 1005 dbSNP
rs1419865464 1006 dbSNP
rs944451453 1015 dbSNP
rs1169445551 1022 dbSNP
rs946037603 1025 dbSNP
rs1258959685 1028 dbSNP
rs1157321773 1032 dbSNP
rs540706596 1040 dbSNP
rs1458087695 1049 dbSNP
rs540731481 1056 dbSNP
rs934471548 1057 dbSNP
rs1218202155 1058 dbSNP
rs1316165870 1064 dbSNP
rs1392753166 1071 dbSNP
rs1054310671 1072 dbSNP
rs1295250590 1078 dbSNP
rs893030874 1083 dbSNP
rs76750482 1086 dbSNP
rs1302282098 1088 dbSNP
rs944420730 1090 dbSNP
rs1401396282 1092 dbSNP
rs1045472314 1098 dbSNP
rs1036143757 1103 dbSNP
rs1335193616 1105 dbSNP
rs1422716501 1110 dbSNP
rs368653355 1110 dbSNP
rs117199202 1111 dbSNP
rs1329840251 1116 dbSNP
rs142350224 1121 dbSNP
rs1270969289 1124 dbSNP
rs1470405467 1126 dbSNP
rs560007421 1127 dbSNP
rs1237286970 1140 dbSNP
rs1196500429 1147 dbSNP
rs78490641 1151 dbSNP
rs781512799 1152 dbSNP
rs962133487 1164 dbSNP
rs775377317 1167 dbSNP
rs1416763239 1172 dbSNP
rs748568843 1173 dbSNP
rs114856673 1174 dbSNP
rs116636658 1178 dbSNP
rs986433451 1191 dbSNP
rs1034795564 1194 dbSNP
rs1445018334 1201 dbSNP
rs543338153 1217 dbSNP
rs1164838228 1224 dbSNP
rs1293694951 1224 dbSNP
rs1456972713 1225 dbSNP
rs1416088011 1227 dbSNP
rs960554910 1234 dbSNP
rs1347568144 1236 dbSNP
rs762729269 1237 dbSNP
rs1419648654 1238 dbSNP
rs1379577601 1247 dbSNP
rs1176621061 1248 dbSNP
rs1020343259 1254 dbSNP
rs1191925932 1264 dbSNP
rs1488216401 1266 dbSNP
rs768325920 1270 dbSNP
rs75248970 1271 dbSNP
rs965643870 1272 dbSNP
rs549510125 1277 dbSNP
rs932251750 1287 dbSNP
rs567768452 1290 dbSNP
rs535440685 1301 dbSNP
rs1330912020 1311 dbSNP
rs1351189223 1313 dbSNP
rs934441787 1321 dbSNP
rs149767230 1330 dbSNP
rs912051023 1338 dbSNP
rs1290155316 1343 dbSNP
rs1054678977 1363 dbSNP
rs914452578 1365 dbSNP
rs1359889606 1367 dbSNP
rs369181183 1370 dbSNP
rs1414437261 1375 dbSNP
rs944828269 1378 dbSNP
rs1436363639 1379 dbSNP
rs1377950596 1387 dbSNP
rs1336651084 1391 dbSNP
rs1036551987 1393 dbSNP
rs565984436 1398 dbSNP
rs897538693 1400 dbSNP
rs1265498536 1411 dbSNP
rs1188415560 1420 dbSNP
rs930421245 1424 dbSNP
rs186334663 1429 dbSNP
rs1044278238 1431 dbSNP
rs1479485344 1441 dbSNP
rs1350528052 1445 dbSNP
rs907135352 1448 dbSNP
rs558066203 1452 dbSNP
rs1197191719 1466 dbSNP
rs1251822316 1467 dbSNP
rs1310140412 1470 dbSNP
rs1485075102 1471 dbSNP
rs750937886 1473 dbSNP
rs1003514416 1481 dbSNP
rs1440026026 1482 dbSNP
rs1056505945 1484 dbSNP
rs576344380 1485 dbSNP
rs897892906 1492 dbSNP
rs1400097506 1503 dbSNP
rs1339197788 1504 dbSNP
rs1296304920 1513 dbSNP
rs773467550 1519 dbSNP
rs1002061450 1521 dbSNP
rs1034869025 1529 dbSNP
rs896424048 1536 dbSNP
rs145879774 1542 dbSNP
rs1028229422 1543 dbSNP
rs887913149 1552 dbSNP
rs749227150 1555 dbSNP
rs1425892799 1562 dbSNP
rs1021216685 1563 dbSNP
rs1422943643 1565 dbSNP
rs1008148969 1566 dbSNP
rs548413441 1571 dbSNP
rs190835686 1572 dbSNP
rs1200301743 1573 dbSNP
rs1482450056 1575 dbSNP
rs566703070 1575 dbSNP
rs1252709269 1588 dbSNP
rs777248459 1593 dbSNP
rs975701715 1595 dbSNP
rs1169902043 1598 dbSNP
rs1371189692 1606 dbSNP
rs541433732 1611 dbSNP
rs1031326579 1614 dbSNP
rs754169507 1619 dbSNP
rs755201872 1623 dbSNP
rs989953322 1624 dbSNP
rs559460159 1628 dbSNP
rs1341064966 1632 dbSNP
rs914307138 1638 dbSNP
rs948554889 1639 dbSNP
rs1333363057 1644 dbSNP
rs980363470 1645 dbSNP
rs1294509149 1648 dbSNP
rs779182103 1651 dbSNP
rs752785784 1655 dbSNP
rs1466378362 1657 dbSNP
rs758510234 1672 dbSNP
rs1399791334 1679 dbSNP
rs912125960 1680 dbSNP
rs551176127 1688 dbSNP
rs1056471669 1701 dbSNP
rs897868440 1706 dbSNP
rs1274934167 1709 dbSNP
rs1278683257 1709 dbSNP
rs1369565912 1713 dbSNP
rs929301294 1726 dbSNP
rs533338420 1727 dbSNP
rs919459287 1738 dbSNP
rs1208152845 1742 dbSNP
rs1240366797 1744 dbSNP
rs1199640266 1749 dbSNP
rs1457073807 1759 dbSNP
rs545412398 1767 dbSNP
rs1215086167 1778 dbSNP
rs930391927 1783 dbSNP
rs868678656 1787 dbSNP
rs1484558874 1798 dbSNP
rs1283556937 1799 dbSNP
rs1242455084 1800 dbSNP
rs1182956048 1809 dbSNP
rs149005535 1818 dbSNP
rs1427133113 1819 dbSNP
rs926402826 1824 dbSNP
rs887872649 1833 dbSNP
rs1007703071 1834 dbSNP
rs937654095 1845 dbSNP
rs1391066291 1854 dbSNP
rs1017751411 1869 dbSNP
rs531010742 1873 dbSNP
rs902088976 1874 dbSNP
rs1434182212 1875 dbSNP
rs1407161804 1876 dbSNP
rs1391497303 1877 dbSNP
rs1056057460 1886 dbSNP
rs1171920144 1889 dbSNP
rs1456884106 1892 dbSNP
rs896375153 1894 dbSNP
rs997756203 1896 dbSNP
rs549123943 1909 dbSNP
rs1439459214 1910 dbSNP
rs182092056 1916 dbSNP
rs1288245224 1921 dbSNP
rs1359543955 1923 dbSNP
rs377323017 1933 dbSNP
rs1383755179 1935 dbSNP
rs1288588689 1936 dbSNP
rs903710487 1938 dbSNP
rs1286629986 1939 dbSNP
rs1297836489 1945 dbSNP
rs777942020 1953 dbSNP
rs770311117 1954 dbSNP
rs1307391946 1956 dbSNP
rs1021352933 1964 dbSNP
rs1281761165 1966 dbSNP
rs1323019807 1976 dbSNP
rs1385153456 1984 dbSNP
rs1007527094 1991 dbSNP
rs1312297677 1992 dbSNP
rs1018989309 1996 dbSNP
rs1419513270 2000 dbSNP
rs528951693 2008 dbSNP
rs1280232848 2009 dbSNP
rs1260707309 2010 dbSNP
rs1478174525 2014 dbSNP
rs547446615 2016 dbSNP
rs928487794 2019 dbSNP
rs1059266 2020 dbSNP
rs919419855 2022 dbSNP
rs952280865 2023 dbSNP
rs780037604 2024 dbSNP
rs1248871814 2032 dbSNP
rs984993007 2036 dbSNP
rs1219556151 2043 dbSNP
rs1453949231 2043 dbSNP
rs753007681 2043 dbSNP
rs757502782 2043 dbSNP
rs1336632022 2045 dbSNP
rs1359148251 2045 dbSNP
rs1399978736 2045 dbSNP
rs1415388622 2045 dbSNP
rs1424044219 2045 dbSNP
rs1491393912 2045 dbSNP
rs34643236 2045 dbSNP
rs376645348 2045 dbSNP
rs529162304 2045 dbSNP
rs71686061 2045 dbSNP
rs746369624 2045 dbSNP
rs199925186 2047 dbSNP
rs1191985955 2058 dbSNP
rs1427302905 2060 dbSNP
rs1433862642 2061 dbSNP
rs1478535588 2063 dbSNP
rs1158257261 2066 dbSNP
rs1343403126 2068 dbSNP
rs551109808 2068 dbSNP
rs1056050842 2069 dbSNP
rs1491064476 2069 dbSNP
rs186747600 2069 dbSNP
rs1458611964 2073 dbSNP
rs150992348 2074 dbSNP
rs1321045343 2081 dbSNP
rs115181749 2088 dbSNP
rs929294052 2091 dbSNP
rs143785116 2093 dbSNP
rs537252820 2095 dbSNP
rs887849434 2100 dbSNP
rs943476410 2106 dbSNP
rs1305207075 2107 dbSNP
rs191581934 2110 dbSNP
rs902057623 2115 dbSNP
rs1360560103 2119 dbSNP
rs551871025 2123 dbSNP
rs1042728157 2125 dbSNP
rs903782218 2125 dbSNP
rs1001084669 2128 dbSNP
rs749072700 2141 dbSNP
rs997640236 2159 dbSNP
rs111755773 2163 dbSNP
rs1400533812 2166 dbSNP
rs1169428301 2168 dbSNP
rs1476549446 2172 dbSNP
rs1415896452 2174 dbSNP
rs1269088525 2190 dbSNP
rs889195273 2192 dbSNP
rs1472355194 2196 dbSNP
rs1235569854 2197 dbSNP
rs1200266343 2198 dbSNP
rs1468341042 2201 dbSNP
rs1258937574 2208 dbSNP
rs1198105312 2220 dbSNP
rs1212001748 2221 dbSNP
rs1007685774 2230 dbSNP
rs1018938742 2233 dbSNP
rs1248720953 2235 dbSNP
rs1313427664 2248 dbSNP
rs768255009 2250 dbSNP
rs1449461154 2257 dbSNP
rs12264592 2261 dbSNP
rs138424763 2277 dbSNP
rs534837492 2281 dbSNP
rs759371819 2284 dbSNP
rs1176755821 2290 dbSNP
rs1351077841 2291 dbSNP
rs892063814 2296 dbSNP
rs1011224488 2297 dbSNP
rs112602376 2304 dbSNP
rs113438618 2305 dbSNP
rs199642597 2313 dbSNP
rs968198443 2317 dbSNP
rs544953408 2318 dbSNP
rs1239023382 2325 dbSNP
rs1035442717 2326 dbSNP
rs771630100 2327 dbSNP
rs1325080909 2334 dbSNP
rs370414172 2340 dbSNP
rs563646295 2349 dbSNP
rs1321715067 2350 dbSNP
rs1290206570 2354 dbSNP
rs1440822406 2370 dbSNP
rs879499149 2378 dbSNP
rs1354786391 2382 dbSNP
rs1473466657 2390 dbSNP
rs575497157 2392 dbSNP
rs1308123195 2402 dbSNP
rs183043323 2407 dbSNP
rs751305428 2438 dbSNP
rs867926260 2439 dbSNP
rs917571252 2444 dbSNP
rs952761767 2446 dbSNP
rs945008179 2451 dbSNP
rs1363652229 2453 dbSNP
rs561174018 2458 dbSNP
rs1334585731 2459 dbSNP
rs977803790 2464 dbSNP
rs1379400946 2466 dbSNP
rs747039858 2468 dbSNP
rs1231885260 2475 dbSNP
rs909237587 2481 dbSNP
rs1269732700 2485 dbSNP
rs528668417 2488 dbSNP
rs1488167489 2497 dbSNP
rs1267391328 2502 dbSNP
rs1219387140 2505 dbSNP
rs1039053721 2518 dbSNP
rs1488835937 2520 dbSNP
rs923363650 2523 dbSNP
rs1237328218 2527 dbSNP
rs1204107088 2528 dbSNP
rs877034 2530 dbSNP
rs185514463 2531 dbSNP
rs189931083 2533 dbSNP
rs377191263 2539 dbSNP
rs901945114 2548 dbSNP
rs777037174 2549 dbSNP
rs1286971406 2550 dbSNP
rs1467377809 2554 dbSNP
rs74677353 2562 dbSNP
rs75180831 2563 dbSNP
rs78849530 2564 dbSNP
rs1042728657 2567 dbSNP
rs1164844052 2569 dbSNP
rs574685806 2580 dbSNP
rs569442752 2586 dbSNP
rs1480170648 2589 dbSNP
rs537315182 2592 dbSNP
rs765452211 2606 dbSNP
rs1035410489 2610 dbSNP
rs1195892105 2611 dbSNP
rs1488940431 2615 dbSNP
rs752978334 2616 dbSNP
rs1394284671 2619 dbSNP
rs993982870 2621 dbSNP
rs1025926999 2629 dbSNP
rs368124168 2634 dbSNP
rs1256259014 2635 dbSNP
rs1208925132 2646 dbSNP
rs767094256 2650 dbSNP
rs1409953013 2655 dbSNP
rs369765811 2658 dbSNP
rs1309134518 2670 dbSNP
rs1293285101 2673 dbSNP
rs1355454271 2673 dbSNP
rs370967313 2680 dbSNP
rs1033792586 2685 dbSNP
rs911141735 2686 dbSNP
rs959563002 2689 dbSNP
rs964646209 2690 dbSNP
rs1024657103 2692 dbSNP
rs1478153446 2692 dbSNP
rs1373010680 2707 dbSNP
rs2881 2709 dbSNP
rs1257357490 2721 dbSNP
rs1271207472 2730 dbSNP
rs978127987 2732 dbSNP
rs1174500040 2744 dbSNP
rs1344371496 2746 dbSNP
rs923342430 2752 dbSNP
rs933438495 2753 dbSNP
rs1316679652 2755 dbSNP
rs936566376 2765 dbSNP
rs1053211282 2772 dbSNP
rs913430927 2773 dbSNP
rs1404702393 2782 dbSNP
rs985403330 2786 dbSNP
rs567386530 2788 dbSNP
rs1311820240 2790 dbSNP
rs947583239 2801 dbSNP
rs1333531170 2802 dbSNP
rs943826902 2812 dbSNP
rs1395801271 2814 dbSNP
rs764301441 2819 dbSNP
rs906129217 2820 dbSNP
rs1183428851 2835 dbSNP
rs1237802644 2836 dbSNP
rs1443101752 2840 dbSNP
rs1239624960 2856 dbSNP
rs751661600 2859 dbSNP
rs1436750138 2871 dbSNP
rs901888833 2875 dbSNP
rs1357033979 2881 dbSNP
rs929439579 2886 dbSNP
rs1056841502 2892 dbSNP
rs1355531836 2894 dbSNP
rs534809930 2895 dbSNP
rs1311766109 2896 dbSNP
rs367838974 2904 dbSNP
rs1447857535 2905 dbSNP
rs1327009213 2910 dbSNP
rs371280970 2917 dbSNP
rs1388581009 2922 dbSNP
rs1184380583 2923 dbSNP
rs1163432731 2927 dbSNP
rs1391671737 2930 dbSNP
rs1382506865 2932 dbSNP
rs1159609231 2933 dbSNP
rs1469348545 2935 dbSNP
rs756172539 2942 dbSNP
rs1200385903 2944 dbSNP
rs993951770 2946 dbSNP
rs41314988 2950 dbSNP
rs137919211 2971 dbSNP
rs1286522775 2972 dbSNP
rs1373108123 2973 dbSNP
rs888236623 2977 dbSNP
rs141648068 2978 dbSNP
rs754811494 2981 dbSNP
rs1018577564 2985 dbSNP
rs1331713890 2987 dbSNP
rs536763319 2996 dbSNP
rs1430515279 3009 dbSNP
rs575209317 3010 dbSNP
rs1013669296 3011 dbSNP
rs547876866 3015 dbSNP
rs1299266902 3020 dbSNP
rs1400429531 3037 dbSNP
rs974703653 3038 dbSNP
rs182134972 3042 dbSNP
rs966855277 3067 dbSNP
rs150504143 3073 dbSNP
rs1302673049 3074 dbSNP
rs1478799634 3074 dbSNP
rs999304976 3081 dbSNP
rs1214824004 3082 dbSNP
rs1445002583 3084 dbSNP
rs1282461365 3090 dbSNP
rs1202349385 3093 dbSNP
rs989263903 3094 dbSNP
rs913324979 3096 dbSNP
rs1221764116 3100 dbSNP
rs1279310327 3100 dbSNP
rs1342948459 3108 dbSNP
rs1279312177 3114 dbSNP
rs947513276 3121 dbSNP
rs771679868 3124 dbSNP
rs116291720 3127 dbSNP
rs1414721687 3128 dbSNP
rs937605566 3131 dbSNP
rs1056809628 3136 dbSNP
rs965295144 3139 dbSNP
rs188016634 3149 dbSNP
rs1185821352 3171 dbSNP
rs1449640489 3176 dbSNP
rs1192625278 3181 dbSNP
rs772756208 3186 dbSNP
rs66516855 3187 dbSNP
rs1461989828 3196 dbSNP
rs1047216099 3197 dbSNP
rs533011761 3204 dbSNP
rs1201853397 3206 dbSNP
rs1417649003 3208 dbSNP
rs1320038748 3230 dbSNP
rs1274346618 3231 dbSNP
rs888213140 3237 dbSNP
rs1005771943 3246 dbSNP
rs1360452938 3247 dbSNP
rs1047838787 3253 dbSNP
rs1453819624 3258 dbSNP
rs1478752892 3261 dbSNP
rs1381602499 3263 dbSNP
rs551418599 3264 dbSNP
rs138673529 3269 dbSNP
rs1400475970 3288 dbSNP
rs998099755 3289 dbSNP
rs1055050849 3293 dbSNP
rs1163687393 3296 dbSNP
rs1443709170 3298 dbSNP
rs372487631 3304 dbSNP
rs954677834 3305 dbSNP
rs988842849 3307 dbSNP
rs372624118 3323 dbSNP
rs1329401287 3332 dbSNP
rs1292576373 3335 dbSNP
rs1247181220 3345 dbSNP
rs1359120446 3347 dbSNP
rs1235568327 3349 dbSNP
rs1312494289 3357 dbSNP
rs1046998525 3360 dbSNP
rs771494008 3362 dbSNP
rs1349944713 3369 dbSNP
rs1370738895 3374 dbSNP
rs193054767 3380 dbSNP
rs375428306 3398 dbSNP
rs927479133 3399 dbSNP
rs1000114428 3400 dbSNP
rs1303642646 3404 dbSNP
rs1423788623 3406 dbSNP
rs1269714843 3413 dbSNP
rs1383203203 3418 dbSNP
rs1160200682 3453 dbSNP
rs937572833 3460 dbSNP
rs1441846116 3471 dbSNP
rs1408964292 3472 dbSNP
rs1032067893 3479 dbSNP
rs1479660295 3485 dbSNP
rs1249000052 3489 dbSNP
rs958027754 3500 dbSNP
rs549340416 3503 dbSNP
rs567550716 3514 dbSNP
rs929600290 3530 dbSNP
rs976690809 3531 dbSNP
rs918405266 3532 dbSNP
rs1363631803 3535 dbSNP
rs768077334 3538 dbSNP
rs1362719657 3539 dbSNP
rs183838146 3547 dbSNP
rs984381966 3548 dbSNP
rs1158606930 3549 dbSNP
rs1417427464 3551 dbSNP
rs1414579376 3552 dbSNP
rs1235398464 3554 dbSNP
rs1427416428 3557 dbSNP
rs1458137290 3568 dbSNP
rs76742234 3569 dbSNP
rs78827591 3574 dbSNP
rs1039941537 3575 dbSNP
rs899638545 3597 dbSNP
rs1259804421 3598 dbSNP
rs997983624 3603 dbSNP
rs759903062 3609 dbSNP
rs1283440137 3619 dbSNP
rs1324223888 3621 dbSNP
rs1335252357 3623 dbSNP
rs1343579584 3628 dbSNP
rs1279942236 3641 dbSNP
rs1382601603 3659 dbSNP
rs1360953283 3667 dbSNP
rs756409333 3702 dbSNP
rs1177318837 3703 dbSNP
rs892401953 3703 dbSNP
rs11544702 3704 dbSNP
rs538772814 3715 dbSNP
rs1010635482 3716 dbSNP
rs776661249 3720 dbSNP
rs188421979 3726 dbSNP
rs1329566322 3739 dbSNP
rs1261518582 3740 dbSNP
rs775679066 3749 dbSNP
rs1185136573 3751 dbSNP
rs1232525728 3756 dbSNP
rs1337108644 3761 dbSNP
rs1020312402 3764 dbSNP
rs1263299632 3766 dbSNP
rs999660000 3769 dbSNP
rs1054368792 3771 dbSNP
rs1320747243 3776 dbSNP
rs577220754 3780 dbSNP
rs1228130261 3790 dbSNP
rs544326870 3792 dbSNP
rs1293262790 3798 dbSNP
rs149321662 3802 dbSNP
rs1481797412 3812 dbSNP
rs778218230 3824 dbSNP
rs1254648715 3828 dbSNP
rs1404057829 3828 dbSNP
rs1452051645 3828 dbSNP
rs1169688930 3829 dbSNP
rs1182546481 3839 dbSNP
rs1243409605 3839 dbSNP
rs1463001777 3839 dbSNP
rs3834417 3839 dbSNP
rs572177353 3839 dbSNP
rs900869292 3839 dbSNP
rs72818122 3840 dbSNP
rs1164733324 3846 dbSNP
rs1249490405 3848 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ggGGUGGAAAAG-AAGGGGg 5'
            || |: || | |||||| 
Target 5' uuCCUCUGUUCCAUUCCCCa 3'
 		3 - 22
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_003901 | 3UTR | UCUUCUGCCUCUUCCCCCUUGAUUCAGCUUUCAGAGGUACU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_003901 | 3UTR | UCUUCCCCCUUGAUUCAGCUUUCAGAGGUACU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_003901 | 3UTR | UUCUUCUGCCUCUUCCCCCUUGAUUCAGCUUUCAGAGGUACU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_003901 | 3UTR | GUUCUUCUGCCUCUUCCCCCUUGAUUCAGCUUUCAGAGGUACU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_003901 | 3UTR | UUCUUCUGCCUCUUCCCCCUUGAUUCAGCUUUCAGAGGUACU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_003901 | 3UTR | AAGACACUUUCCUCUGUUCCAUUCCCCAUCUCAGGGACUCCUGAAUAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000373202.3 | 3UTR | CUUUCCUCUGUUCCAUUCCCCAUCUCAGGGACUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
181 hsa-miR-4271 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066209 MARCH9 membrane associated ring-CH-type finger 9 2 2
MIRT079367 CCDC137 coiled-coil domain containing 137 2 2
MIRT081183 MIDN midnolin 2 4
MIRT083278 ZCCHC3 zinc finger CCHC-type containing 3 2 6
MIRT086207 HOXD13 homeobox D13 2 2
MIRT133713 SKI SKI proto-oncogene 2 4
MIRT150653 SLC27A1 solute carrier family 27 member 1 2 2
MIRT159166 NRBP1 nuclear receptor binding protein 1 2 2
MIRT160059 TET3 tet methylcytosine dioxygenase 3 2 4
MIRT180856 RPRD2 regulation of nuclear pre-mRNA domain containing 2 2 2
MIRT181931 MARK2 microtubule affinity regulating kinase 2 2 2
MIRT190628 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT190654 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT196107 MPRIP myosin phosphatase Rho interacting protein 2 2
MIRT263248 SGPL1 sphingosine-1-phosphate lyase 1 2 2
MIRT321168 EIF4H eukaryotic translation initiation factor 4H 2 2
MIRT338624 SHMT2 serine hydroxymethyltransferase 2 2 2
MIRT366301 GDI1 GDP dissociation inhibitor 1 2 4
MIRT375172 ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 2 2
MIRT441488 NCEH1 neutral cholesterol ester hydrolase 1 2 2
MIRT442333 WNT9B Wnt family member 9B 2 2
MIRT443889 CNKSR3 CNKSR family member 3 2 2
MIRT445880 WBP1L WW domain binding protein 1 like 2 2
MIRT449312 MRO maestro 2 2
MIRT449844 BCL2L13 BCL2 like 13 2 2
MIRT450304 DRAXIN dorsal inhibitory axon guidance protein 2 2
MIRT450515 EMX1 empty spiracles homeobox 1 2 2
MIRT451243 ZNF444 zinc finger protein 444 2 2
MIRT451713 OLR1 oxidized low density lipoprotein receptor 1 2 2
MIRT451792 TLR5 toll like receptor 5 2 2
MIRT451823 ALDH3B1 aldehyde dehydrogenase 3 family member B1 2 2
MIRT451906 ILK integrin linked kinase 2 2
MIRT452181 KIAA1456 KIAA1456 2 4
MIRT452242 TRAM1 translocation associated membrane protein 1 2 2
MIRT452544 ZNF467 zinc finger protein 467 2 2
MIRT452605 REPIN1 replication initiator 1 2 2
MIRT454505 ZFYVE27 zinc finger FYVE-type containing 27 2 2
MIRT454657 FBXL18 F-box and leucine rich repeat protein 18 2 2
MIRT455354 KDM5C lysine demethylase 5C 2 2
MIRT455452 EPB41L4B erythrocyte membrane protein band 4.1 like 4B 2 2
MIRT455587 TAF12 TATA-box binding protein associated factor 12 2 2
MIRT456501 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 2 2
MIRT456815 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT457425 NOL10 nucleolar protein 10 2 2
MIRT457468 SLC35F6 solute carrier family 35 member F6 2 2
MIRT457660 SERINC1 serine incorporator 1 2 2
MIRT458231 NXPH3 neurexophilin 3 2 2
MIRT458374 ITM2C integral membrane protein 2C 2 2
MIRT458667 GPR35 G protein-coupled receptor 35 2 2
MIRT459665 VPS37C VPS37C, ESCRT-I subunit 2 2
MIRT459825 TPP1 tripeptidyl peptidase 1 2 2
MIRT460564 FEM1A fem-1 homolog A 2 2
MIRT460725 ASXL3 additional sex combs like 3, transcriptional regulator 2 2
MIRT461121 RAB36 RAB36, member RAS oncogene family 2 2
MIRT461529 C14orf1 ergosterol biosynthesis 28 homolog 2 2
MIRT461750 DDX11 DEAD/H-box helicase 11 2 2
MIRT462570 STS steroid sulfatase 2 2
MIRT462798 NTN1 netrin 1 2 2
MIRT463030 ZNF689 zinc finger protein 689 2 2
MIRT463991 WDTC1 WD and tetratricopeptide repeats 1 2 2
MIRT464684 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465439 TP53 tumor protein p53 2 2
MIRT465512 PRICKLE4 prickle planar cell polarity protein 4 2 2
MIRT465649 TNPO2 transportin 2 2 10
MIRT465947 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466028 TMEM189 transmembrane protein 189 2 2
MIRT468076 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 6
MIRT468131 SH3PXD2A SH3 and PX domains 2A 2 2
MIRT468498 SESN2 sestrin 2 2 2
MIRT468879 RREB1 ras responsive element binding protein 1 2 2
MIRT469318 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT469558 RARA retinoic acid receptor alpha 2 2
MIRT469793 RAB15 RAB15, member RAS oncogene family 2 2
MIRT469896 PTRF caveolae associated protein 1 2 2
MIRT470235 PRRC2A proline rich coiled-coil 2A 2 2
MIRT470808 PLXND1 plexin D1 2 2
MIRT471597 PAQR5 progestin and adipoQ receptor family member 5 2 10
MIRT471710 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT471752 OGT O-linked N-acetylglucosamine (GlcNAc) transferase 2 2
MIRT472978 MRRF mitochondrial ribosome recycling factor 2 2
MIRT473538 MAX MYC associated factor X 2 2
MIRT473581 MAT2A methionine adenosyltransferase 2A 2 2
MIRT473970 LRRC58 leucine rich repeat containing 58 2 2
MIRT474223 LCOR ligand dependent nuclear receptor corepressor 2 4
MIRT474553 KLHDC3 kelch domain containing 3 2 2
MIRT474777 KIAA0895L KIAA0895 like 2 2
MIRT476042 GRSF1 G-rich RNA sequence binding factor 1 2 2
MIRT476438 GBA2 glucosylceramidase beta 2 2 2
MIRT477773 E2F3 E2F transcription factor 3 2 4
MIRT477946 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT478782 CRTC2 CREB regulated transcription coactivator 2 2 2
MIRT479320 VPS72 vacuolar protein sorting 72 homolog 2 2
MIRT480405 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT480593 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2 2
MIRT480963 BBC3 BCL2 binding component 3 2 2
MIRT481127 AZIN1 antizyme inhibitor 1 2 4
MIRT481444 ARRB2 arrestin beta 2 2 2
MIRT481687 AR androgen receptor 2 2
MIRT481730 APH1A aph-1 homolog A, gamma-secretase subunit 2 2
MIRT482386 AEN apoptosis enhancing nuclease 2 2
MIRT482564 ABHD2 abhydrolase domain containing 2 2 2
MIRT482605 ABHD14B abhydrolase domain containing 14B 2 2
MIRT483256 CITED4 Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 4 2 4
MIRT483531 TAGLN2 transgelin 2 2 2
MIRT483840 UNC5B unc-5 netrin receptor B 2 4
MIRT483935 LENG8 leukocyte receptor cluster member 8 2 4
MIRT484414 SNX19 sorting nexin 19 2 2
MIRT484487 SLC9A1 solute carrier family 9 member A1 2 2
MIRT484609 SIX3 SIX homeobox 3 2 6
MIRT484703 RNF11 ring finger protein 11 2 2
MIRT485244 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT485607 FOSL1 FOS like 1, AP-1 transcription factor subunit 2 4
MIRT485965 RTBDN retbindin 2 2
MIRT487308 GLTSCR1 BRD4 interacting chromatin remodeling complex associated protein 2 2
MIRT487329 SREBF1 sterol regulatory element binding transcription factor 1 2 4
MIRT487410 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT487607 C20orf96 chromosome 20 open reading frame 96 2 2
MIRT487689 CDK14 cyclin dependent kinase 14 2 2
MIRT487787 GPR20 G protein-coupled receptor 20 2 4
MIRT488026 ADO 2-aminoethanethiol dioxygenase 2 2
MIRT488476 B3GALNT2 beta-1,3-N-acetylgalactosaminyltransferase 2 2 2
MIRT488761 FXYD1 FXYD domain containing ion transport regulator 1 2 2
MIRT489161 MRPL12 mitochondrial ribosomal protein L12 2 4
MIRT489529 MRE11A MRE11 homolog, double strand break repair nuclease 2 8
MIRT489774 GRINA glutamate ionotropic receptor NMDA type subunit associated protein 1 2 2
MIRT489878 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT490094 FN3K fructosamine 3 kinase 2 2
MIRT490202 PKNOX2 PBX/knotted 1 homeobox 2 2 2
MIRT490283 ISL2 ISL LIM homeobox 2 2 2
MIRT490377 LHFPL3 LHFPL tetraspan subfamily member 3 2 2
MIRT491035 ALPK3 alpha kinase 3 2 2
MIRT491186 JUND JunD proto-oncogene, AP-1 transcription factor subunit 2 4
MIRT491766 ZNF385A zinc finger protein 385A 2 2
MIRT491888 YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon 2 2
MIRT491981 UNK unkempt family zinc finger 2 2
MIRT492400 SDK1 sidekick cell adhesion molecule 1 2 2
MIRT493647 HDLBP high density lipoprotein binding protein 2 2
MIRT494010 DUSP9 dual specificity phosphatase 9 2 2
MIRT494167 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 2
MIRT495712 PADI1 peptidyl arginine deiminase 1 2 2
MIRT496873 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT499175 RBPJL recombination signal binding protein for immunoglobulin kappa J region like 2 2
MIRT501652 PHLDA3 pleckstrin homology like domain family A member 3 2 2
MIRT506645 MAPK1 mitogen-activated protein kinase 1 2 4
MIRT510590 TUBB2A tubulin beta 2A class IIa 2 6
MIRT511907 FKBP1A FK506 binding protein 1A 2 2
MIRT513063 ANKRD45 ankyrin repeat domain 45 2 2
MIRT513104 DYNAP dynactin associated protein 2 2
MIRT521804 POM121C POM121 transmembrane nucleoporin C 2 2
MIRT523520 GLUL glutamate-ammonia ligase 2 2
MIRT525085 FRK fyn related Src family tyrosine kinase 2 2
MIRT530930 SCIN scinderin 2 2
MIRT533501 TRIM71 tripartite motif containing 71 2 2
MIRT538560 CECR2 CECR2, histone acetyl-lysine reader 2 2
MIRT544556 CSNK2A1 casein kinase 2 alpha 1 2 2
MIRT555912 ORMDL3 ORMDL sphingolipid biosynthesis regulator 3 2 2
MIRT560405 TMEM69 transmembrane protein 69 2 2
MIRT560664 RTN3 reticulon 3 2 2
MIRT564061 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT565504 SP1 Sp1 transcription factor 2 2
MIRT570014 COL1A2 collagen type I alpha 2 chain 2 2
MIRT572321 HSPB6 heat shock protein family B (small) member 6 2 2
MIRT573229 TRIM21 tripartite motif containing 21 2 2
MIRT573487 IQSEC3 IQ motif and Sec7 domain 3 2 2
MIRT574137 MARVELD1 MARVEL domain containing 1 2 2
MIRT574323 ZNF703 zinc finger protein 703 2 2
MIRT620939 OSMR oncostatin M receptor 2 2
MIRT650080 MTL5 testis expressed metallothionein like protein 2 2
MIRT684553 ZNF708 zinc finger protein 708 2 2
MIRT685841 ANGEL1 angel homolog 1 2 2
MIRT688551 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT701985 MIER3 MIER family member 3 2 2
MIRT703899 EPT1 selenoprotein I 2 2
MIRT706388 MC2R melanocortin 2 receptor 2 2
MIRT707487 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT711885 INSIG2 insulin induced gene 2 2 2
MIRT719164 KIF6 kinesin family member 6 2 2
MIRT721294 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT721775 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 2 2
MIRT723763 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT725485 GPR26 G protein-coupled receptor 26 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4271 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (BGC823)
hsa-miR-4271 Platinum-based doublet chemotherapy sensitive High Lung Adenocarcinoma tissue
hsa-miR-4271 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4271 Fluorouracil 3385 NSC19893 approved sensitive High Pancreatic Cancer cell line (PATU8988)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved resistant Low Tongue Squamous Cell Carcinoma cell line (CAL-27, SCC-9)
hsa-miR-4271 Paclitaxel 36314 NSC125973 approved resistant High Non-Small Cell Lung Cancer cell line (H460)
hsa-miR-4271 Anlotinib 25017411 NSC832523 sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-miR-4271 Gefitinib 123631 NSC715055 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-miR-4271 Icotinib 22024915 NSC800770 sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-miR-4271 Erlotinib 176870 NSC718781 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549, PDC, H460)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (W1)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-4271 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-4271 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-mir-4271 Cisplatin 5460033 NSC119875 approved sensitive cell line (BGC-823)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (total RNA)
hsa-miR-4271 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-4271 Platinum-based doublet chemotherapy sensitive tissue (lung adenocarcinoma)
hsa-miR-4271 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4271 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-4271 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4271 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4271 Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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