miRTarBase - #MIRT263337


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pre-miRNA Information
pre-miRNA hsa-mir-488   
Genomic Coordinates chr1: 177029363 - 177029445
Synonyms MIRN488, hsa-mir-488, MIR488
Description Homo sapiens miR-488 stem-loop
Comment miR-488-3p cloned in has a 1 nt 3' extension (U), which is incompatible with the genome sequence.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-488-3p
Sequence 52| UUGAAAGGCUAUUUCUUGGUC |72
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 5 1 - 177029390 27229138, 28550310, 29165639, 29233923 MiREDiBase
A-to-I 6 1 - 177029389 29233923 MiREDiBase
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN1079766 12 COSMIC
COSN19660590 16 COSMIC
COSN30190142 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1210074726 7 dbSNP
rs1310911055 17 dbSNP
rs1248997320 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ANAPC16   
Synonyms APC16, C10orf104, CENP-27, MSAG, bA570G20.3
Description anaphase promoting complex subunit 16
Transcript NM_173473   
Expression
Putative miRNA Targets on ANAPC16
3'UTR of ANAPC16
(miRNA target sites are highlighted)		 
>ANAPC16|NM_173473|3'UTR
   1 TACTGCCTGGATGGTCACCTCTGGTGCGCAGCAAGTGCAAAGCCAGTGGGGGACTTTCTCACAGCTTACATAGCCATCCA
  81 GAGATCCACAGCTACGTCACTGAATTGTTAATGCACATTTGTACTTGGTTTCTCTGTATCTATTCACAGGCAACAAATAC
 161 TTATATGTGTGATCTTTCAGGGAATGTTTTGTTTATTTGTTTTTAAAAGTATTGGGAATCAGATTAAGACAATCAGTTTC
 241 AGAGAACCAGGAGGTTTGGGGTTAAGAGATACTCAAAAATTTTCACAAGCCAAGTAGGGCATATATCAGATTTGGCCAAC
 321 TGAATGGCGTCTGTCCTGTCATCCATATGGTGCCTGGAAATATTTACCAGTCAAGGTCAAGGTCAGCATCTGTGGTTAAA
 401 AATATAGCATTCTGACCTAAAAAAGTTATTTTGCAGATGAATGTGTTTTCAACTCAGGACCTATCCAAATGAGGAATTTT
 481 TAAATATTCTTTTTTTTTTCCTATTTTTAGACATCAATTCTATAGATTCTGACTTTTTCTAACCTCTTATAGACATGCCA
 561 AATGCTGGCAAAAAGAAGTGCTTTTTGGATATGGCAGCACTTGTAAAAATAAAGCAGTAAGCAAAATCCTTTTAAACACA
 641 GAAATCCTGAGTTCTTCTCATTGGTGGACTCAAGCAATTCTGTAGCAAATAAATCCTTTGAAAGAGCTCCAAATTGGTGG
 721 CATTATCCTTTCAAAATCTCAGGGATTTGGGATGAAGTGAAGAGGTCAAATTACTTTTTAGAAGAAGGGAATCTAAAAAC
 801 CATCTCTCCTAAACAAATGGTAGACTGGCTTTACTTAAGGGATATTTGTCTTTATAGGAGTACATAAATTTATCTTAATG
 881 ATATTTAAGTAGTTTTTTTTTTTTTTTGAGACGAAGTTTTGCTCTTGTTGCCCAGGCTGTATCGCAATGGCGCGATCTCT
 961 GCTCACTGCAACATCCACCTCCCAGGTTCAAGCAATTCTCCTGCCTCAGCCTCCCAAGTAGCTGGGATTACAGGCACCCG
1041 CCACCACACCCAGCTAATTTTTTGTATATTTAGTAGAGACGGGGTTTCACCATGTTGACCAGGCTAGTCTCGAACTTCTG
1121 ACCTCAGGTGATCCACCTGCCTCAGCCTCCCAAATTGCTGGGATTACAGGCGTGAGCCACCTTGCCCAGCCAATTTTTTT
1201 TTAAAGAGACATGGTCTTGCTATGTTGCCCAGGTTGGTCTTGAACTCCTGGCCTCAAGAGATCCCCCCAACCTTGGCCTC
1281 CAAAGTGCTGGGATTACAGGCATGAGCCACCGCGCCTGGCCTCAAGTAAGTTTTTATACCATGATAGGGGAAAACCTGGA
1361 AGGCTAAGAGATGTGCTGTTTTCCTTCATGGGACCCCACTTTCCACAGTAAACAACTGGTATAATCATTTATTACGTTGT
1441 ATGCAAATTTTGCCTTAGACAACATTTGTCTGGTTCCTTATTAATAACTTGCATCTGATCTGCTTAGAGTTGCTTAATTA
1521 TAAGTAAATATAATCCCAGTAGCATTTAGCCTTAATCTCAAGAGTTCAAAATGTTTAACACATTCTACCTGACGGGAGGT
1601 GGTGACCTCATTCAGTCGGTTAAGAGCCTGAGCCCTGTGAAGTTAAACACCTGCTCATGGTCACATAGCCCAGGCAGAAG
1681 AAAATCTCGGACTTGGAATAGATCCCAGTTGCCTGATAATTCATCTCATTATTGCCTCTAAAGCAAATTGGAGACTGGGC
1761 ACAGTGGCTCCCACCTTTAATCCCAGCACCTGGGGAGGCTGAGGTGAGTGGATCACTAGAGGTCAGGAGTTCAAGACCAG
1841 TCTGGCCGACATGGTGAAACTCAGTCTCTATTGAAAATACAAAAATTAGCTCAGTGTGGTGGCACACACTTGTAATCCCA
1921 GCTACTCAGGAGGCTGAGGCATGAGAATCGCTTAAACCCAGGAGGCGGAGGTTGCAGTGAGCTGAGATCACACCATTGCA
2001 CTCTAGTCTGGGTGACAGAGCGAGACTCTGTCTCAAAAAAAAAAAAATAAAGCCGGGCGTGGTGGCTCACGCCTGTAATC
2081 CCGGCACTTTGGGAGGCTGAGGCAGGCGGATTGCCTGAGATCGGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCT
2161 TGTCTCTACTAAAACTACAAAAAAAATTAGCCAGGCGTGGTGGCGGGCGCCTGTAATCCCAGCTACTCAGGAGGCTGAGG
2241 CAGCAGAATCGTTTGAACCCGGGAGGCGGAGGTTGCAGTGAGTGGAGATCGTGCCTGTGTGCTCCAGCCTGAGCAACAAG
2321 AGCGAAACTGTCTCAAAAAAAAGAAGAAAATAAATAAATAAAAATCAGAGCACAAGAAGTACCAGTCCACCAACTCACAT
2401 TTTCTATATTAATAATTCTTAACTAAAAGAAGTTCCATATTCGACAGCATTTTAGTTTTTTAATAGTACTTATTAGCATC
2481 AACCATCTTGATAATCACCAAGGGAAAAATTAAAAATACCTAGACTGCAATAAACCTTTAAATTGGATTTTCAGTGAGAA
2561 TTTAGAAGCAATCACTACCTTTCTCGTTTCATTTGTGTAACCATGCAGCATAGGCACTGTGTTACATCATCTTTACGCTT
2641 TGGTATTTGAACTTATTACAGAATTTTTTCTCTAAATTGGATGTTTCTTTATATGACCTTGGAAACTGAAGTGATCTTAG
2721 CATTAAACAAAAATGCTTTTTGAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cugguUCUUUAUCGGAAAGUu 5'
               :| | || ||||||| 
Target 5' ttggtGGCATTATCCTTTCAa 3'
 714 - 734 152.00 -9.00
2 
miRNA  3' cugGUUCUUUAUCGGAAAGUu 5'
             :||| || | |||||:| 
Target 5' cagTAAGCAAAATCCTTTTAa 3'
 615 - 635 146.00 -7.80
3 
miRNA  3' cugGUUCUUUAUCGGAAAGuu 5'
             |||  | || ||||||  
Target 5' aagCAATCACTA-CCTTTCtc 3'
 2566 - 2585 133.00 -6.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26965960 18 COSMIC
COSN18734842 66 COSMIC
COSN31523651 116 COSMIC
COSN30510340 120 COSMIC
COSN15694179 215 COSMIC
COSN4694969 250 COSMIC
COSN7067961 310 COSMIC
COSN8189257 330 COSMIC
COSN8719877 477 COSMIC
COSN31570391 479 COSMIC
COSN24832734 500 COSMIC
COSN28953023 500 COSMIC
COSN18857554 501 COSMIC
COSN31584278 521 COSMIC
COSN28681697 645 COSMIC
COSN31571350 655 COSMIC
COSN8719878 758 COSMIC
COSN1500021 766 COSMIC
COSN27835303 875 COSMIC
COSN23957021 909 COSMIC
COSN16375030 944 COSMIC
COSN5253595 1002 COSMIC
COSN8719879 1082 COSMIC
COSN5253596 1150 COSMIC
COSN26114663 1191 COSMIC
COSN16543268 1429 COSMIC
COSN25484878 1690 COSMIC
COSN27779276 1807 COSMIC
COSN7067962 1895 COSMIC
COSN17861641 1898 COSMIC
COSN5883186 2409 COSMIC
COSN19057461 2626 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1372805847 1 dbSNP
rs930627472 2 dbSNP
rs751852740 3 dbSNP
rs374220486 4 dbSNP
rs13980 6 dbSNP
rs756558579 9 dbSNP
rs778278608 12 dbSNP
rs1389009212 14 dbSNP
rs748761104 15 dbSNP
rs1276996866 17 dbSNP
rs1315979361 19 dbSNP
rs1234562648 21 dbSNP
rs770515817 22 dbSNP
rs768813451 26 dbSNP
rs370996491 27 dbSNP
rs201778398 28 dbSNP
rs200589401 29 dbSNP
rs1040509527 36 dbSNP
rs774575440 39 dbSNP
rs771762149 41 dbSNP
rs775365092 45 dbSNP
rs1203544897 48 dbSNP
rs901991171 51 dbSNP
rs11553566 56 dbSNP
rs1172074075 63 dbSNP
rs117571297 66 dbSNP
rs1174149633 69 dbSNP
rs1398029119 71 dbSNP
rs556056095 72 dbSNP
rs1037371826 79 dbSNP
rs867702468 81 dbSNP
rs1264014783 90 dbSNP
rs1209624302 96 dbSNP
rs1401063945 97 dbSNP
rs751406042 117 dbSNP
rs1281139310 122 dbSNP
rs1050954815 124 dbSNP
rs558551026 126 dbSNP
rs1317837276 128 dbSNP
rs1256644080 129 dbSNP
rs1221014884 135 dbSNP
rs79296695 143 dbSNP
rs757034252 150 dbSNP
rs1338388336 163 dbSNP
rs1256098458 166 dbSNP
rs1335927862 174 dbSNP
rs1136518 187 dbSNP
rs1034771912 196 dbSNP
rs150377726 206 dbSNP
rs971879282 212 dbSNP
rs1262102431 223 dbSNP
rs1467143149 231 dbSNP
rs1424375205 235 dbSNP
rs1181405107 243 dbSNP
rs112788757 244 dbSNP
rs1026191596 262 dbSNP
rs952073058 265 dbSNP
rs76524739 266 dbSNP
rs1195598093 269 dbSNP
rs1020963036 270 dbSNP
rs545385958 273 dbSNP
rs1457549178 280 dbSNP
rs1256579864 285 dbSNP
rs113676816 288 dbSNP
rs907340468 291 dbSNP
rs1319258819 292 dbSNP
rs910529281 305 dbSNP
rs1273073733 308 dbSNP
rs1227301867 310 dbSNP
rs755950394 313 dbSNP
rs1285525895 314 dbSNP
rs1452934271 316 dbSNP
rs943404148 318 dbSNP
rs1249532266 321 dbSNP
rs779076603 329 dbSNP
rs923360152 330 dbSNP
rs934779004 350 dbSNP
rs1401013243 353 dbSNP
rs990997984 358 dbSNP
rs748140547 361 dbSNP
rs185334791 365 dbSNP
rs1467683871 366 dbSNP
rs1439348579 370 dbSNP
rs962702727 393 dbSNP
rs1180955257 397 dbSNP
rs947613970 406 dbSNP
rs1246709913 410 dbSNP
rs1044677878 412 dbSNP
rs904855132 415 dbSNP
rs1244917908 416 dbSNP
rs576639588 416 dbSNP
rs1453209980 417 dbSNP
rs1220014886 419 dbSNP
rs918506722 419 dbSNP
rs1001860275 429 dbSNP
rs1291432632 430 dbSNP
rs986620318 432 dbSNP
rs911082747 435 dbSNP
rs1360197482 436 dbSNP
rs778124693 437 dbSNP
rs1034696976 440 dbSNP
rs1242136470 442 dbSNP
rs1373792020 451 dbSNP
rs1292812979 454 dbSNP
rs1300464695 459 dbSNP
rs896242983 466 dbSNP
rs1351646280 467 dbSNP
rs993266075 469 dbSNP
rs1419302212 485 dbSNP
rs893101880 488 dbSNP
rs1160822257 489 dbSNP
rs544019705 489 dbSNP
rs878879967 490 dbSNP
rs946041802 490 dbSNP
rs1489772833 492 dbSNP
rs1003106761 493 dbSNP
rs951939152 494 dbSNP
rs1302632476 495 dbSNP
rs1332310205 501 dbSNP
rs1237395447 502 dbSNP
rs1284799846 504 dbSNP
rs1218356284 516 dbSNP
rs1353981073 518 dbSNP
rs1300362820 519 dbSNP
rs894662391 523 dbSNP
rs1369697984 529 dbSNP
rs1283990267 534 dbSNP
rs1399553257 542 dbSNP
rs562110197 545 dbSNP
rs1289354570 547 dbSNP
rs1017558728 551 dbSNP
rs1358908902 553 dbSNP
rs555703412 556 dbSNP
rs976085592 557 dbSNP
rs1193578829 562 dbSNP
rs972803802 572 dbSNP
rs1260439212 576 dbSNP
rs541492088 599 dbSNP
rs923329102 610 dbSNP
rs1195341530 630 dbSNP
rs1025344857 638 dbSNP
rs11000229 645 dbSNP
rs1331392978 650 dbSNP
rs533398438 655 dbSNP
rs986734530 662 dbSNP
rs1176861636 664 dbSNP
rs777075405 665 dbSNP
rs942535916 667 dbSNP
rs990211806 668 dbSNP
rs914707725 669 dbSNP
rs1440574626 685 dbSNP
rs778530058 687 dbSNP
rs1378784801 689 dbSNP
rs946186328 690 dbSNP
rs551775751 693 dbSNP
rs541474133 697 dbSNP
rs570743851 700 dbSNP
rs1393530387 707 dbSNP
rs927576818 713 dbSNP
rs1464548406 715 dbSNP
rs937639343 718 dbSNP
rs866987103 721 dbSNP
rs1056075273 723 dbSNP
rs1307941289 724 dbSNP
rs896210277 727 dbSNP
rs1194754087 733 dbSNP
rs1428730776 735 dbSNP
rs760108711 739 dbSNP
rs1377125054 742 dbSNP
rs1179764070 744 dbSNP
rs1047496381 750 dbSNP
rs559859574 760 dbSNP
rs1197890402 771 dbSNP
rs1316034201 775 dbSNP
rs1260050952 780 dbSNP
rs894606882 780 dbSNP
rs1321200460 782 dbSNP
rs1006085567 784 dbSNP
rs1017901303 788 dbSNP
rs189068751 789 dbSNP
rs997490824 792 dbSNP
rs137865090 802 dbSNP
rs1456409303 804 dbSNP
rs993955642 805 dbSNP
rs568114114 807 dbSNP
rs955037307 812 dbSNP
rs1237616772 814 dbSNP
rs1008114074 829 dbSNP
rs1018207447 840 dbSNP
rs1180737018 844 dbSNP
rs1411965096 847 dbSNP
rs1423541048 855 dbSNP
rs573088922 865 dbSNP
rs1385600288 866 dbSNP
rs914697267 878 dbSNP
rs1370665175 881 dbSNP
rs1464544638 885 dbSNP
rs1456379019 888 dbSNP
rs58974704 892 dbSNP
rs113517546 893 dbSNP
rs199668653 893 dbSNP
rs5786065 893 dbSNP
rs990381200 893 dbSNP
rs535266289 894 dbSNP
rs967846291 895 dbSNP
rs977493199 896 dbSNP
rs927526452 898 dbSNP
rs938690844 900 dbSNP
rs1223955960 909 dbSNP
rs1157825924 911 dbSNP
rs1437526309 913 dbSNP
rs1378010718 914 dbSNP
rs1228632421 917 dbSNP
rs576848339 923 dbSNP
rs1182382776 925 dbSNP
rs1432559456 927 dbSNP
rs889020958 928 dbSNP
rs938949044 929 dbSNP
rs1224894285 931 dbSNP
rs1490573434 932 dbSNP
rs1057343639 934 dbSNP
rs1055763711 943 dbSNP
rs181810221 944 dbSNP
rs565422118 945 dbSNP
rs1047925849 952 dbSNP
rs763795400 953 dbSNP
rs539074465 954 dbSNP
rs373738531 955 dbSNP
rs898013170 956 dbSNP
rs1006445896 962 dbSNP
rs1182758006 980 dbSNP
rs993889474 986 dbSNP
rs1465471776 990 dbSNP
rs761391492 996 dbSNP
rs60558719 1002 dbSNP
rs1007894724 1020 dbSNP
rs1262598357 1022 dbSNP
rs1191729329 1038 dbSNP
rs1251034246 1040 dbSNP
rs1170589193 1041 dbSNP
rs1200302781 1048 dbSNP
rs900366964 1063 dbSNP
rs1017986043 1064 dbSNP
rs1224684032 1065 dbSNP
rs1425045837 1074 dbSNP
rs964291249 1075 dbSNP
rs997417409 1081 dbSNP
rs1030293543 1082 dbSNP
rs1327889666 1085 dbSNP
rs1011513663 1092 dbSNP
rs1399811510 1093 dbSNP
rs1173353650 1095 dbSNP
rs1021852418 1101 dbSNP
rs1358166145 1108 dbSNP
rs956018689 1110 dbSNP
rs1422972232 1112 dbSNP
rs1168682596 1114 dbSNP
rs1476508223 1120 dbSNP
rs1242985219 1127 dbSNP
rs1304269689 1129 dbSNP
rs1021429209 1136 dbSNP
rs201470688 1138 dbSNP
rs1010246682 1141 dbSNP
rs1022089505 1150 dbSNP
rs977440757 1153 dbSNP
rs1278695316 1158 dbSNP
rs1212358079 1164 dbSNP
rs968848420 1172 dbSNP
rs980648315 1173 dbSNP
rs576692978 1181 dbSNP
rs960150748 1187 dbSNP
rs1338445410 1188 dbSNP
rs1216360471 1191 dbSNP
rs1276619961 1192 dbSNP
rs532807368 1194 dbSNP
rs915939324 1194 dbSNP
rs927451834 1194 dbSNP
rs4293052 1195 dbSNP
rs1211052608 1203 dbSNP
rs1411666382 1210 dbSNP
rs1037970948 1213 dbSNP
rs112124969 1223 dbSNP
rs1471954303 1228 dbSNP
rs551001968 1238 dbSNP
rs1264445546 1242 dbSNP
rs1476686278 1246 dbSNP
rs1184652566 1251 dbSNP
rs1051972245 1256 dbSNP
rs1236813871 1259 dbSNP
rs1207259490 1262 dbSNP
rs928928955 1262 dbSNP
rs1423817257 1263 dbSNP
rs1414608869 1271 dbSNP
rs983159017 1273 dbSNP
rs373052716 1282 dbSNP
rs1358242078 1284 dbSNP
rs908928946 1287 dbSNP
rs77300823 1293 dbSNP
rs1246530861 1304 dbSNP
rs7922264 1310 dbSNP
rs1038827761 1312 dbSNP
rs544259551 1313 dbSNP
rs933175677 1314 dbSNP
rs186440920 1315 dbSNP
rs1274228563 1320 dbSNP
rs891721037 1327 dbSNP
rs1403797080 1329 dbSNP
rs1010628907 1330 dbSNP
rs1011878578 1337 dbSNP
rs545433712 1340 dbSNP
rs1021640222 1345 dbSNP
rs1021548547 1346 dbSNP
rs1439408204 1346 dbSNP
rs113114434 1347 dbSNP
rs1470822574 1357 dbSNP
rs531636629 1358 dbSNP
rs142770456 1370 dbSNP
rs1220262464 1376 dbSNP
rs1489720018 1379 dbSNP
rs568336973 1393 dbSNP
rs1034433873 1394 dbSNP
rs1222790107 1400 dbSNP
rs1352652515 1403 dbSNP
rs1304648013 1409 dbSNP
rs1351789975 1420 dbSNP
rs752876283 1422 dbSNP
rs992962677 1431 dbSNP
rs1025811299 1436 dbSNP
rs758502279 1437 dbSNP
rs370649575 1440 dbSNP
rs147507732 1442 dbSNP
rs1358991265 1443 dbSNP
rs1161798977 1449 dbSNP
rs188112239 1450 dbSNP
rs1425167778 1462 dbSNP
rs1219997738 1463 dbSNP
rs1479139616 1471 dbSNP
rs1270443597 1474 dbSNP
rs1199648444 1475 dbSNP
rs1487784122 1476 dbSNP
rs908862231 1482 dbSNP
rs1217757693 1485 dbSNP
rs72806294 1489 dbSNP
rs866528651 1492 dbSNP
rs868535553 1493 dbSNP
rs1277757857 1498 dbSNP
rs963418017 1501 dbSNP
rs557745938 1524 dbSNP
rs974024884 1529 dbSNP
rs1284046244 1539 dbSNP
rs180917644 1543 dbSNP
rs1378053527 1551 dbSNP
rs921687400 1557 dbSNP
rs1438717134 1560 dbSNP
rs537049521 1562 dbSNP
rs1051616312 1566 dbSNP
rs1358968054 1571 dbSNP
rs891677080 1574 dbSNP
rs1403466404 1580 dbSNP
rs1322796998 1587 dbSNP
rs758401173 1593 dbSNP
rs186245406 1594 dbSNP
rs142950303 1595 dbSNP
rs1039466863 1599 dbSNP
rs1437202040 1610 dbSNP
rs1259144032 1613 dbSNP
rs1043390348 1615 dbSNP
rs947074520 1618 dbSNP
rs1239653289 1619 dbSNP
rs1236711107 1628 dbSNP
rs1310350025 1636 dbSNP
rs904519245 1638 dbSNP
rs1043152020 1639 dbSNP
rs1001521739 1652 dbSNP
rs1208440441 1654 dbSNP
rs1289704273 1657 dbSNP
rs1297927196 1658 dbSNP
rs998755060 1661 dbSNP
rs1034360264 1669 dbSNP
rs1378852674 1670 dbSNP
rs1335195509 1674 dbSNP
rs747245588 1690 dbSNP
rs1035466477 1709 dbSNP
rs1014349448 1715 dbSNP
rs1172034860 1721 dbSNP
rs541663227 1723 dbSNP
rs1447203388 1749 dbSNP
rs1384355166 1750 dbSNP
rs1235808424 1752 dbSNP
rs1181589806 1755 dbSNP
rs1462595357 1756 dbSNP
rs1243609013 1766 dbSNP
rs1197950498 1769 dbSNP
rs1025757152 1771 dbSNP
rs951657982 1784 dbSNP
rs553567294 1786 dbSNP
rs1205453677 1799 dbSNP
rs1178865737 1800 dbSNP
rs1321406862 1817 dbSNP
rs578152123 1820 dbSNP
rs1313362814 1822 dbSNP
rs1017639598 1824 dbSNP
rs1248533670 1834 dbSNP
rs529609959 1845 dbSNP
rs963042903 1846 dbSNP
rs191483962 1847 dbSNP
rs530164108 1848 dbSNP
rs545470721 1849 dbSNP
rs757504265 1855 dbSNP
rs769134622 1865 dbSNP
rs1026761366 1867 dbSNP
rs1462970400 1871 dbSNP
rs781713072 1872 dbSNP
rs1398195581 1881 dbSNP
rs945909113 1883 dbSNP
rs987740088 1891 dbSNP
rs6480601 1892 dbSNP
rs925868284 1894 dbSNP
rs937302464 1896 dbSNP
rs1055739072 1897 dbSNP
rs975527855 1904 dbSNP
rs181417358 1909 dbSNP
rs1225029667 1919 dbSNP
rs1360565850 1926 dbSNP
rs1243012739 1928 dbSNP
rs1283993796 1930 dbSNP
rs1357549613 1943 dbSNP
rs1235650243 1944 dbSNP
rs947155345 1950 dbSNP
rs1338105329 1951 dbSNP
rs1316739827 1952 dbSNP
rs1198743211 1955 dbSNP
rs575588477 1959 dbSNP
rs1014275859 1960 dbSNP
rs1252145100 1961 dbSNP
rs1440368273 1968 dbSNP
rs1186521234 1983 dbSNP
rs1237805920 1984 dbSNP
rs1344339068 1984 dbSNP
rs1476102797 1997 dbSNP
rs1042712566 1998 dbSNP
rs924300507 2006 dbSNP
rs1451532803 2017 dbSNP
rs58340123 2022 dbSNP
rs1182452197 2023 dbSNP
rs934551707 2026 dbSNP
rs12572740 2027 dbSNP
rs1056985951 2029 dbSNP
rs1490588802 2034 dbSNP
rs1261451712 2035 dbSNP
rs533318269 2035 dbSNP
rs567612790 2035 dbSNP
rs1233189582 2041 dbSNP
rs1322167189 2044 dbSNP
rs1406373710 2045 dbSNP
rs895614111 2045 dbSNP
rs1012750812 2049 dbSNP
rs1462770694 2053 dbSNP
rs143941950 2055 dbSNP
rs529124109 2055 dbSNP
rs1170036973 2056 dbSNP
rs887276965 2058 dbSNP
rs1469263244 2059 dbSNP
rs770382976 2060 dbSNP
rs547206162 2062 dbSNP
rs1333806818 2065 dbSNP
rs1026294826 2069 dbSNP
rs964664634 2071 dbSNP
rs995815181 2072 dbSNP
rs1028650081 2076 dbSNP
rs1009117242 2083 dbSNP
rs559084362 2084 dbSNP
rs987216491 2086 dbSNP
rs1224739544 2087 dbSNP
rs913005974 2098 dbSNP
rs1342327578 2099 dbSNP
rs1224823076 2102 dbSNP
rs1327946675 2104 dbSNP
rs1199520426 2106 dbSNP
rs967200929 2107 dbSNP
rs1403902249 2108 dbSNP
rs143611105 2109 dbSNP
rs1470311489 2111 dbSNP
rs770008028 2123 dbSNP
rs1191243338 2124 dbSNP
rs567005382 2131 dbSNP
rs937248451 2132 dbSNP
rs1055663432 2143 dbSNP
rs551237070 2150 dbSNP
rs917248631 2152 dbSNP
rs950090906 2160 dbSNP
rs1245445207 2161 dbSNP
rs375873838 2165 dbSNP
rs1204883364 2166 dbSNP
rs968475801 2167 dbSNP
rs1271724060 2172 dbSNP
rs978934157 2179 dbSNP
rs1047108086 2195 dbSNP
rs1464668539 2197 dbSNP
rs748897550 2198 dbSNP
rs887193190 2205 dbSNP
rs1172203423 2208 dbSNP
rs1376311019 2209 dbSNP
rs1436903572 2210 dbSNP
rs924246467 2213 dbSNP
rs569714608 2214 dbSNP
rs1340401298 2221 dbSNP
rs1423072332 2226 dbSNP
rs1038957425 2227 dbSNP
rs113541243 2235 dbSNP
rs1298458517 2242 dbSNP
rs1328830727 2244 dbSNP
rs1231902307 2245 dbSNP
rs768161349 2252 dbSNP
rs1303598410 2253 dbSNP
rs1349639243 2256 dbSNP
rs1214116128 2259 dbSNP
rs997081524 2261 dbSNP
rs1029958216 2262 dbSNP
rs536674512 2268 dbSNP
rs1265253436 2269 dbSNP
rs1008985502 2278 dbSNP
rs773795987 2283 dbSNP
rs967549913 2284 dbSNP
rs1293725158 2285 dbSNP
rs551711595 2288 dbSNP
rs978587804 2291 dbSNP
rs1444389865 2292 dbSNP
rs1351203245 2295 dbSNP
rs1198254554 2296 dbSNP
rs1333964067 2298 dbSNP
rs1423015348 2303 dbSNP
rs1044217994 2305 dbSNP
rs1367822526 2312 dbSNP
rs1164676884 2318 dbSNP
rs899012028 2323 dbSNP
rs1033243206 2324 dbSNP
rs12262347 2325 dbSNP
rs1455767417 2329 dbSNP
rs991360164 2331 dbSNP
rs886398692 2335 dbSNP
rs917174765 2340 dbSNP
rs1454683518 2342 dbSNP
rs1470852254 2342 dbSNP
rs1291082737 2343 dbSNP
rs1008899050 2344 dbSNP
rs750014001 2348 dbSNP
rs1270762919 2350 dbSNP
rs1222121660 2389 dbSNP
rs950015494 2405 dbSNP
rs964973879 2407 dbSNP
rs1385688813 2411 dbSNP
rs996852308 2419 dbSNP
rs983206971 2420 dbSNP
rs1403319587 2421 dbSNP
rs908597489 2421 dbSNP
rs186886712 2428 dbSNP
rs1372600354 2430 dbSNP
rs968631895 2440 dbSNP
rs941429814 2443 dbSNP
rs567973372 2444 dbSNP
rs1308161754 2455 dbSNP
rs535294952 2462 dbSNP
rs1240934199 2464 dbSNP
rs1038477071 2474 dbSNP
rs1430894406 2475 dbSNP
rs955824755 2476 dbSNP
rs146794603 2479 dbSNP
rs1240179920 2483 dbSNP
rs932839886 2486 dbSNP
rs1051313657 2497 dbSNP
rs578236347 2500 dbSNP
rs1469911726 2501 dbSNP
rs1008537843 2518 dbSNP
rs1221690717 2520 dbSNP
rs1379928362 2522 dbSNP
rs1325773852 2523 dbSNP
rs552319834 2526 dbSNP
rs1214238864 2535 dbSNP
rs1360276433 2553 dbSNP
rs1291050675 2555 dbSNP
rs1436450085 2564 dbSNP
rs557208877 2566 dbSNP
rs1335326933 2567 dbSNP
rs575673223 2572 dbSNP
rs1467725029 2586 dbSNP
rs920404355 2587 dbSNP
rs1176291071 2591 dbSNP
rs1427604415 2601 dbSNP
rs760370875 2604 dbSNP
rs542677537 2612 dbSNP
rs1242389817 2613 dbSNP
rs1367184908 2615 dbSNP
rs1201715020 2618 dbSNP
rs958499459 2620 dbSNP
rs753721289 2637 dbSNP
rs879258947 2638 dbSNP
rs1327210564 2643 dbSNP
rs1261945424 2651 dbSNP
rs1024153130 2657 dbSNP
rs1229512556 2675 dbSNP
rs1382521131 2678 dbSNP
rs561302165 2681 dbSNP
rs1455087855 2684 dbSNP
rs1380675437 2721 dbSNP
rs1302977177 2735 dbSNP
rs1330202693 2737 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 119504.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cugguucuUUAUCGGAAAGUu 5'
                  | || ||||||| 
Target 5' -------cAUUAUCCUUUCAa 3'
 		1 - 14
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000299381.4 | 3UTR | CAUUAUCCUUUCAAAAUCUCAGGGAUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE32688 Pancreatic cancer 0.429 7.1e-3 0.434 6.5e-3 32 Click to see details
GSE21687 Ependynoma primary tumors -0.229 3.4e-2 -0.119 1.7e-1 64 Click to see details
GSE19350 CNS germ cell tumors 0.359 1.3e-1 0.476 5.9e-2 12 Click to see details
GSE42095 Differentiated embryonic stem cells -0.235 1.4e-1 -0.176 2.1e-1 23 Click to see details
GSE38226 Liver fibrosis 0.217 1.7e-1 0.514 8.6e-3 21 Click to see details
GSE26953 Aortic valvular endothelial cells -0.182 2.0e-1 0.000 5.0e-1 24 Click to see details
GSE28544 Breast cancer 0.171 2.1e-1 0.039 4.3e-1 24 Click to see details
GSE28260 Renal cortex and medulla 0.148 3.1e-1 0.207 2.5e-1 13 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.096 3.2e-1 0.052 4.0e-1 25 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.468 3.4e-1 0.500 3.3e-1 3 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.056 4.1e-1 -0.385 4.7e-2 20 Click to see details
GSE17306 Multiple myeloma -0.023 4.4e-1 0.465 3.8e-4 49 Click to see details
GSE21849 B cell lymphoma -0.024 4.5e-1 -0.136 2.4e-1 29 Click to see details
GSE27834 Pluripotent stem cells -0.002 5.0e-1 -0.047 4.3e-1 16 Click to see details
GSE27834 Pluripotent stem cells -0.002 5.0e-1 -0.047 4.3e-1 16 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
KIRP 0.634 0.13 0.700 0.09 5 Click to see details
BRCA -0.257 0.2 -0.286 0.17 13 Click to see details
ESCA 0.799 0.21 1.000 0.5 3 Click to see details
LIHC -0.244 0.28 -0.238 0.29 8 Click to see details
PCPG 0.508 0.33 0.500 0.33 3 Click to see details
PRAD 0.089 0.37 0.297 0.13 16 Click to see details
HNSC -0.16 0.38 -0.086 0.44 6 Click to see details
LUSC -0.111 0.42 0.257 0.31 6 Click to see details
THCA -0.086 0.46 0.000 0.5 4 Click to see details
UCEC -0.018 0.48 0.371 0.12 12 Click to see details
UCEC -0.018 0.48 0.371 0.12 12 Click to see details
UCEC -0.018 0.48 0.371 0.12 12 Click to see details
UCEC -0.018 0.48 0.371 0.12 12 Click to see details
UCEC -0.018 0.48 0.371 0.12 12 Click to see details
UCEC -0.018 0.48 0.371 0.12 12 Click to see details
116 hsa-miR-488-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT005899 POMC proopiomelanocortin 3 1
MIRT038008 CYP2E1 cytochrome P450 family 2 subfamily E member 1 1 1
MIRT054483 SLC39A8 solute carrier family 39 member 8 2 1
MIRT058884 C11ORF58 chromosome 11 open reading frame 58 2 2
MIRT061194 MED17 mediator complex subunit 17 2 2
MIRT167237 TMEM167A transmembrane protein 167A 2 2
MIRT188343 ARID1A AT-rich interaction domain 1A 2 2
MIRT218170 MRPL18 mitochondrial ribosomal protein L18 2 2
MIRT218297 C6ORF120 chromosome 6 open reading frame 120 2 2
MIRT263337 ANAPC16 anaphase promoting complex subunit 16 2 2
MIRT294633 ZNF548 zinc finger protein 548 2 2
MIRT305053 SRPRB SRP receptor beta subunit 2 6
MIRT306846 FYTTD1 forty-two-three domain containing 1 2 2
MIRT442753 NRIP3 nuclear receptor interacting protein 3 2 2
MIRT443955 S1PR2 sphingosine-1-phosphate receptor 2 2 2
MIRT444032 SYNM synemin 2 2
MIRT444519 WWTR1 WW domain containing transcription regulator 1 2 2
MIRT444569 UNC5C unc-5 netrin receptor C 2 2
MIRT444779 ECE1 endothelin converting enzyme 1 2 2
MIRT445195 FAXC failed axon connections homolog 2 2
MIRT445345 FAM169A family with sequence similarity 169 member A 2 2
MIRT445539 TBC1D8 TBC1 domain family member 8 2 2
MIRT446058 RABIF RAB interacting factor 2 2
MIRT446358 EFCAB6 EF-hand calcium binding domain 6 2 2
MIRT446486 PRELP proline and arginine rich end leucine rich repeat protein 2 2
MIRT446973 CARKD NAD(P)HX dehydratase 2 2
MIRT446984 MOB1B MOB kinase activator 1B 2 2
MIRT446987 TMEM9B TMEM9 domain family member B 2 2
MIRT447376 AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 2 2
MIRT447857 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT448077 BRMS1L breast cancer metastasis-suppressor 1 like 2 2
MIRT448970 CBX5 chromobox 5 2 2
MIRT449072 RPS15A ribosomal protein S15a 2 2
MIRT449200 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT449459 HAT1 histone acetyltransferase 1 2 2
MIRT449588 PCDHA6 protocadherin alpha 6 2 2
MIRT449885 ZNF621 zinc finger protein 621 2 2
MIRT449892 C11orf34 placenta expressed transcript 1 1 2
MIRT450669 SGIP1 SH3 domain GRB2 like endophilin interacting protein 1 2 2
MIRT450866 GPR107 G protein-coupled receptor 107 2 2
MIRT450881 EIF6 eukaryotic translation initiation factor 6 2 2
MIRT455373 AAED1 AhpC/TSA antioxidant enzyme domain containing 1 2 2
MIRT458266 FUT10 fucosyltransferase 10 2 2
MIRT464839 RPS27A ribosomal protein S27a 2 12
MIRT465335 TPM3 tropomyosin 3 2 4
MIRT467939 SLC16A1 solute carrier family 16 member 1 2 2
MIRT468719 SDC4 syndecan 4 2 2
MIRT469844 PXK PX domain containing serine/threonine kinase like 2 8
MIRT474545 KLHDC3 kelch domain containing 3 2 2
MIRT480700 BRPF1 bromodomain and PHD finger containing 1 2 2
MIRT482087 ALG8 ALG8, alpha-1,3-glucosyltransferase 2 2
MIRT491225 KCNA5 potassium voltage-gated channel subfamily A member 5 2 2
MIRT497790 DTX3L deltex E3 ubiquitin ligase 3L 2 2
MIRT497831 GPR26 G protein-coupled receptor 26 2 2
MIRT497910 HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 2 2
MIRT498428 DDX39A DExD-box helicase 39A 2 2
MIRT499196 TJAP1 tight junction associated protein 1 2 2
MIRT500396 ZNF281 zinc finger protein 281 2 6
MIRT501523 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 10
MIRT504445 MC2R melanocortin 2 receptor 2 2
MIRT505270 TUBB2A tubulin beta 2A class IIa 2 2
MIRT508584 CCDC115 coiled-coil domain containing 115 2 12
MIRT509269 NPM3 nucleophosmin/nucleoplasmin 3 2 4
MIRT512466 CCDC149 coiled-coil domain containing 149 2 2
MIRT513534 PRDM2 PR/SET domain 2 2 4
MIRT514218 ZNF83 zinc finger protein 83 2 4
MIRT518526 FLCN folliculin 2 6
MIRT524841 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT524855 ARL5B ADP ribosylation factor like GTPase 5B 2 4
MIRT525048 FRK fyn related Src family tyrosine kinase 2 2
MIRT528635 SENP6 SUMO1/sentrin specific peptidase 6 2 2
MIRT529557 SNRNP48 small nuclear ribonucleoprotein U11/U12 subunit 48 2 2
MIRT532319 GHSR growth hormone secretagogue receptor 2 2
MIRT534232 SLC25A16 solute carrier family 25 member 16 2 2
MIRT534254 SLC12A7 solute carrier family 12 member 7 2 2
MIRT536223 LRRC41 leucine rich repeat containing 41 2 2
MIRT537658 ERBB2IP erbb2 interacting protein 2 2
MIRT537795 EIF1AX eukaryotic translation initiation factor 1A, X-linked 2 2
MIRT540404 PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 2 2
MIRT544563 POLDIP3 DNA polymerase delta interacting protein 3 2 2
MIRT546045 VPS4B vacuolar protein sorting 4 homolog B 2 2
MIRT546846 RAB4A RAB4A, member RAS oncogene family 2 2
MIRT548480 EEF2 eukaryotic translation elongation factor 2 2 2
MIRT549337 ARF6 ADP ribosylation factor 6 2 2
MIRT550855 SNAP47 synaptosome associated protein 47 2 4
MIRT551607 ZNF267 zinc finger protein 267 2 2
MIRT553222 TWF1 twinfilin actin binding protein 1 2 2
MIRT553874 SUPT7L SPT7 like, STAGA complex gamma subunit 2 4
MIRT557956 FAM222B family with sequence similarity 222 member B 2 2
MIRT559264 BAG4 BCL2 associated athanogene 4 2 4
MIRT562245 GRWD1 glutamate rich WD repeat containing 1 2 2
MIRT563184 YDJC YdjC chitooligosaccharide deacetylase homolog 2 2
MIRT563834 SMDT1 single-pass membrane protein with aspartate rich tail 1 2 2
MIRT563967 RAB6A RAB6A, member RAS oncogene family 2 2
MIRT564808 ZBTB21 zinc finger and BTB domain containing 21 2 2
MIRT565188 TSHZ1 teashirt zinc finger homeobox 1 2 2
MIRT565549 SMG1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase 2 2
MIRT566969 LBR lamin B receptor 2 2
MIRT570926 ZNF284 zinc finger protein 284 2 2
MIRT612283 ZMAT3 zinc finger matrin-type 3 2 2
MIRT612695 PKNOX1 PBX/knotted 1 homeobox 1 2 2
MIRT625293 ZNF619 zinc finger protein 619 2 2
MIRT628496 LINS lines homolog 1 2 2
MIRT640282 FAM169B family with sequence similarity 169 member B 2 2
MIRT647212 CYP2U1 cytochrome P450 family 2 subfamily U member 1 2 2
MIRT654668 PSMB5 proteasome subunit beta 5 2 2
MIRT657516 HAS2 hyaluronan synthase 2 2 2
MIRT670337 C1orf106 chromosome 1 open reading frame 106 2 4
MIRT702010 MIDN midnolin 2 2
MIRT704253 DHCR24 24-dehydrocholesterol reductase 2 2
MIRT710205 ENAH ENAH, actin regulator 2 2
MIRT712126 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT714890 COQ10B coenzyme Q10B 2 2
MIRT716588 PAX6 paired box 6 2 2
MIRT720810 CIAO1 cytosolic iron-sulfur assembly component 1 2 2
MIRT724953 AHCY adenosylhomocysteinase 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-488 Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-488 Diethylstilbestrol approved 448537 Microarray mammosphere-derived epithelial cells (MDEC) 19549897 2009 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-488 Doxorubicin 31703 NSC123127 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-488 Chemotherapy sensitive High Epithelial Ovarian Cancer tissue
hsa-miR-488 Cisplatin 5460033 NSC119875 approved resistant Low Non-Small Cell Lung Cancer cell line (A549, H1299)
hsa-miR-488 Daunorubicin 30323 NSC82151 approved resistant High Acute Promyelocytic Leukemia cell line (HL60)
hsa-miR-488 Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (A375)
hsa-miR-488 Taxane 9548828 sensitive High Breast Cancer tissue
hsa-miR-488 Doxorubicin 31703 NSC123127 approved sensitive High Anaplastic Thyroid Cancer tissue
hsa-mir-488 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-488 Fluorouracil 3385 NSC19893 approved resistant cell line (OE19)
hsa-miR-488 Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-488 Pegylated interferon alpha+Ribavirin sensitive tissue (chronic hepatitis C)
hsa-miR-488 Doxorubicin 31703 NSC123127 approved resistant cell line (K562)
hsa-miR-488 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-488-3p Paclitaxel 36314 NSC125973 approved resistant High Prostate Cancer cell line (DU-145, PC-3)
hsa-miR-488-3p Cisplatin 5460033 NSC119875 approved sensitive Low Melanoma cell line (SK-Mel-28)
hsa-miR-488-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-488-3p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-488-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)

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