miRTarBase - #MIRT263519


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pre-miRNA Information
pre-miRNA hsa-mir-4677   
Genomic Coordinates chr1: 243346176 - 243346255
Description Homo sapiens miR-4677 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4677-5p
Sequence 13| UUGUUCUUUGGUCUUUCAGCCA |34
Evidence Experimental
Experiments Illumina
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN10045564 8 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1050583047 19 dbSNP
rs1425855779 21 dbSNP
Putative Targets

Gene Information
Gene Symbol RPS24   
Synonyms DBA3, S24
Description ribosomal protein S24
Transcript NM_001142285   
Other Transcripts NM_001026 , NM_001142282 , NM_001142284 , NM_001142283 , NM_033022   
Expression
Putative miRNA Targets on RPS24
3'UTR of RPS24
(miRNA target sites are highlighted)		 
>RPS24|NM_001142285|3'UTR
   1 TGTCACTGCCATGGCCGCCTTGCTGCATTTCTGAGGATGCTTCATCTCTCCACCTTCTTCTCCACTCAGCAGCCAGCAGG
  81 GCACTGTGGAAATCGGAGTCACATGAGCTGGCACCTCTGTTCAGAACCCTCCAGGGCTCCACATCTCTCTCACCCAAATG
 161 CCAAAGACCTCCCCACGCCCCCACAATCCCCCACGACCTGGCCACTGGCCTCCCACCACCTTCCAGCTCCAGCGGCTCCT
 241 ACCACATTTAAGGCTTTCCTTCCTAGTTTTAATTTTTCCTCGTCAGCAGTTGATTTTATTATTTTCTTGTTTATTGGTAT
 321 TTTCCCACTAGAAATGAAGCTGCGTGAAGTTAGAGATTTTTTTTTTTGGTCTGTGTTCCTAATTAGCTCATTGCTATACC
 401 CCTGGCGCCCAGAACAATGCCTTGGACACAGTACGCAGTAGACTAAATAAATACTTGTTGAATGACTGACTGACGGAATG
 481 ACGGCTGTGTGGGGAGTGGATTGGGTCGTGAGGCAGAGGCTGCGGTGGAAACTCAGGCAGGAGGTGATGGTGGTTCTTGG
 561 GGCTGCGGAATGCCAAGTTTAGAAGCTCTTCCTCTGCTGTGGCACATGAACCGGTCACTCGAGAAGGCTTTTAGATTTAC
 641 TTTGCCTAATCCCCTCTTAGTGCATGTGGGGAAACTGAGGTACACAAAAGGAATTCCCCACCAAGTTAGGGGCAGAACCT
 721 AGCCCCCTTGTCTCCCAGATGGATATCTTCTTTTTTTTTTGAGACGGAGTCTTGCTCTGTTGCCCAGGCTGGAGTGCAGT
 801 GGTACCATCTTGGCTCACTGCAACCTCTGCTTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCTGAGTGTCTGCGAT
 881 TACAGGTGCACACAACCACGCCTGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCGTGTTGGTCAGGGTGACC
 961 TCAAACTCCTGACCTCATGATCCACCCAGCTCAGCCTCCCAACGTGCTGGGATTACAGGCATGAGCCACCGTGCCTGGCT
1041 GGACATCTTGTTATTAAAGCTTCTTCTCTCTTTGTAGGGGAGGGGGAGATGCCTCTGGTGGAGAAGACCAGTGTGGCAGT
1121 GACTGTGTCTGTTAGTGAACCTGGTGGCTGGTTGAGGGTCTGTCGTGGTGACTGAGGACACATACAAAGTGCTTTTCTCA
1201 GTGGTCACCTTGGTGTTGGTGAATAAGGGTCAGAAGATGGCTCCTGTCCTAGGGCACTGCCAGTCGGTTTGGAAGCTGAA
1281 ATGCCTGCTTAGCAGTTTGAGGAAACACAGACCTTGGAGGATCTTCTGGTTGCCTCTTCAAGAATTCATTCTATTCCCCT
1361 TCTGCTCCCCAAATTTGCTTTTCTTGGGGTGGGTCTTGGTTGGCCTAAGCCAAGAAAGTATGGCATCTACTCCTTCCATA
1441 GCAATAGCTCAGGAATAGGCAGTGACCCAGACCTGAACCAATCAGTGCATGGAATTACCCCTGGCCAAAGTGGTTGATTG
1521 AGGCTGGGTGCAAGCAGAGTTGTGAGAAGGCTCCCATTTGGTGGTTGGAGAGATCGCACTTGCTCCAGAGGTCATAATGT
1601 GCAGATCTGAGGCTTGGAACTGCTGCAGACATTTTGCTACCACAAGTGAAGCCACCCTGACGACACAGTTGACAATTTGG
1681 AGCAGGGCAGAGCTGAGAGAACAGCAGGGAAACAGCCAGAGTCTTGCTCAAGCCTCCCTGAAGTATCTATACCCCTGGAC
1761 TCTAGTTATGGGGGCTAATAAATGTTATATACTGTTTAAGGTAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' acCGACUU-UCUGG--UUUCUUGUu 5'
            || |:: ||| |  |:|||||| 
Target 5' gaGCAGGGCAGAGCTGAGAGAACAg 3'
 1680 - 1704 142.00 -15.10
2 
miRNA  3' accGACUUUCUGGUUUCUUGUu 5'
             |||: :||  :|||| || 
Target 5' cctCTGGTGGA--GAAGACCAg 3'
 1092 - 1111 123.00 -12.74
3 
miRNA  3' accGACUUUCUGGUUUCUUGUu 5'
             ||| : | ||  |||||| 
Target 5' cccCTG-GCGCCC--AGAACAa 3'
 399 - 417 121.00 -10.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1187759 101 ClinVar
COSN31587210 39 COSMIC
COSN17370154 95 COSMIC
COSN1122889 332 COSMIC
COSN17606784 408 COSMIC
COSN17182052 875 COSMIC
COSN23453092 1005 COSMIC
COSN27091365 1032 COSMIC
COSN8189869 1166 COSMIC
COSN19493751 1318 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs536067246 11 dbSNP
rs183560808 12 dbSNP
rs1461562425 13 dbSNP
rs769160910 17 dbSNP
rs765237160 18 dbSNP
rs1394569670 22 dbSNP
rs939483296 26 dbSNP
rs1354588689 38 dbSNP
rs1453945212 40 dbSNP
rs1385664506 61 dbSNP
rs566667298 62 dbSNP
rs1286545030 69 dbSNP
rs532561240 77 dbSNP
rs992187317 78 dbSNP
rs538598613 95 dbSNP
rs1423505183 96 dbSNP
rs1422410713 97 dbSNP
rs114149556 101 dbSNP
rs1163989263 101 dbSNP
rs1446330450 104 dbSNP
rs1031462188 106 dbSNP
rs142851690 116 dbSNP
rs537930998 129 dbSNP
rs925561105 130 dbSNP
rs763076568 135 dbSNP
rs1219055451 143 dbSNP
rs1489924638 146 dbSNP
rs1052652717 148 dbSNP
rs1307524226 154 dbSNP
rs1247207476 155 dbSNP
rs554751714 156 dbSNP
rs1406691537 165 dbSNP
rs1291773480 166 dbSNP
rs915650254 168 dbSNP
rs377427583 176 dbSNP
rs540845064 178 dbSNP
rs560812258 179 dbSNP
rs973069775 185 dbSNP
rs1214980791 187 dbSNP
rs899554259 188 dbSNP
rs995179101 190 dbSNP
rs1297221370 193 dbSNP
rs1026609954 195 dbSNP
rs188440005 196 dbSNP
rs1226955895 201 dbSNP
rs151068494 206 dbSNP
rs1169651311 207 dbSNP
rs562732070 210 dbSNP
rs1429108412 213 dbSNP
rs1420243838 216 dbSNP
rs1195938663 217 dbSNP
rs1490717713 220 dbSNP
rs1225355735 226 dbSNP
rs1245532230 231 dbSNP
rs1035553838 234 dbSNP
rs531644670 235 dbSNP
rs1421857405 237 dbSNP
rs1447890240 240 dbSNP
rs751662641 247 dbSNP
rs1204374145 254 dbSNP
rs916674466 264 dbSNP
rs1385927846 280 dbSNP
rs548257521 282 dbSNP
rs1162556840 283 dbSNP
rs561879004 287 dbSNP
rs1283492425 291 dbSNP
rs1406461844 302 dbSNP
rs140313250 311 dbSNP
rs1297406772 317 dbSNP
rs1462373005 318 dbSNP
rs969406125 336 dbSNP
rs529802136 337 dbSNP
rs925269207 345 dbSNP
rs1428727940 356 dbSNP
rs1177022006 357 dbSNP
rs1481219401 357 dbSNP
rs35734754 357 dbSNP
rs397828117 357 dbSNP
rs576615131 357 dbSNP
rs5786317 357 dbSNP
rs200785086 369 dbSNP
rs1362500716 371 dbSNP
rs1433902126 372 dbSNP
rs1315380892 374 dbSNP
rs1360953795 376 dbSNP
rs1226156963 379 dbSNP
rs750225211 382 dbSNP
rs546497651 384 dbSNP
rs566736490 385 dbSNP
rs1234889647 392 dbSNP
rs996897418 403 dbSNP
rs192833809 407 dbSNP
rs753015915 408 dbSNP
rs1391779589 415 dbSNP
rs1334567228 418 dbSNP
rs141004459 421 dbSNP
rs1244015821 427 dbSNP
rs1177257356 432 dbSNP
rs1467741870 435 dbSNP
rs552483529 436 dbSNP
rs1158720478 438 dbSNP
rs150188824 444 dbSNP
rs1240488898 447 dbSNP
rs995251050 448 dbSNP
rs778227693 454 dbSNP
rs1048092311 467 dbSNP
rs1243148106 471 dbSNP
rs886760564 473 dbSNP
rs139078073 475 dbSNP
rs1003861379 476 dbSNP
rs1355574358 478 dbSNP
rs370707915 483 dbSNP
rs1401225209 488 dbSNP
rs1161289396 492 dbSNP
rs1036031371 508 dbSNP
rs758150474 509 dbSNP
rs1382936303 517 dbSNP
rs1288506665 519 dbSNP
rs959916608 520 dbSNP
rs1162064743 521 dbSNP
rs749862750 524 dbSNP
rs555857874 525 dbSNP
rs920397595 528 dbSNP
rs184005974 537 dbSNP
rs541091857 548 dbSNP
rs559326016 560 dbSNP
rs979474722 567 dbSNP
rs80146678 568 dbSNP
rs1289276416 581 dbSNP
rs1245007766 585 dbSNP
rs1359951649 589 dbSNP
rs1283106992 590 dbSNP
rs956938656 593 dbSNP
rs944312907 598 dbSNP
rs376774408 608 dbSNP
rs1041170386 609 dbSNP
rs142271202 613 dbSNP
rs79628312 614 dbSNP
rs1362724248 621 dbSNP
rs146163875 622 dbSNP
rs1366622738 627 dbSNP
rs1165502575 653 dbSNP
rs975615917 658 dbSNP
rs999247293 661 dbSNP
rs576010402 666 dbSNP
rs921422212 667 dbSNP
rs1478572455 676 dbSNP
rs1266301701 682 dbSNP
rs931078255 684 dbSNP
rs376530939 685 dbSNP
rs1208526499 688 dbSNP
rs1291836427 692 dbSNP
rs1014193593 693 dbSNP
rs1022765546 706 dbSNP
rs1269629552 713 dbSNP
rs1342501895 721 dbSNP
rs188152089 724 dbSNP
rs534205505 725 dbSNP
rs1263933324 726 dbSNP
rs1325953470 727 dbSNP
rs994715049 735 dbSNP
rs1444354671 743 dbSNP
rs1027806207 746 dbSNP
rs1426681959 750 dbSNP
rs1466705686 750 dbSNP
rs1248171977 751 dbSNP
rs950522402 751 dbSNP
rs983500676 751 dbSNP
rs1236974847 752 dbSNP
rs1437112414 752 dbSNP
rs1470588459 756 dbSNP
rs746551338 761 dbSNP
rs768158540 766 dbSNP
rs939692587 767 dbSNP
rs1409722143 778 dbSNP
rs1472119301 783 dbSNP
rs1056762584 787 dbSNP
rs776466271 799 dbSNP
rs911573546 802 dbSNP
rs1412407230 811 dbSNP
rs1335590104 814 dbSNP
rs1332629085 816 dbSNP
rs1333160985 821 dbSNP
rs965564610 821 dbSNP
rs1175094376 826 dbSNP
rs1354587943 829 dbSNP
rs1443792467 831 dbSNP
rs895776879 836 dbSNP
rs976972657 838 dbSNP
rs1156495795 839 dbSNP
rs1012778782 844 dbSNP
rs1022783083 847 dbSNP
rs368869583 853 dbSNP
rs747936688 856 dbSNP
rs1241278520 859 dbSNP
rs932803386 860 dbSNP
rs1000008423 863 dbSNP
rs1443129925 871 dbSNP
rs372435023 878 dbSNP
rs546732599 879 dbSNP
rs376462651 881 dbSNP
rs1350396976 883 dbSNP
rs560079260 886 dbSNP
rs1310467500 887 dbSNP
rs1242867866 889 dbSNP
rs773275465 891 dbSNP
rs370982100 895 dbSNP
rs1347665931 900 dbSNP
rs1019621932 901 dbSNP
rs1315779742 914 dbSNP
rs1399809237 915 dbSNP
rs1380615405 924 dbSNP
rs532383532 927 dbSNP
rs895823204 930 dbSNP
rs1438439603 932 dbSNP
rs373650390 933 dbSNP
rs1483618483 943 dbSNP
rs921453437 944 dbSNP
rs931483761 949 dbSNP
rs1446644249 954 dbSNP
rs1287141600 960 dbSNP
rs1219276340 963 dbSNP
rs1482696344 966 dbSNP
rs984273021 968 dbSNP
rs545328381 970 dbSNP
rs1044329282 974 dbSNP
rs1431136932 975 dbSNP
rs552165146 991 dbSNP
rs1380688893 993 dbSNP
rs563433674 1001 dbSNP
rs774242599 1003 dbSNP
rs995059685 1005 dbSNP
rs1027506479 1011 dbSNP
rs1422484706 1012 dbSNP
rs1364806812 1017 dbSNP
rs191450498 1018 dbSNP
rs1165384911 1021 dbSNP
rs1057235655 1031 dbSNP
rs142817294 1032 dbSNP
rs1415967896 1033 dbSNP
rs948663403 1046 dbSNP
rs1184889609 1051 dbSNP
rs1477591460 1060 dbSNP
rs1264145876 1062 dbSNP
rs1004641715 1063 dbSNP
rs1305652533 1066 dbSNP
rs1044310589 1069 dbSNP
rs904420043 1075 dbSNP
rs974416079 1077 dbSNP
rs548211729 1079 dbSNP
rs568123369 1088 dbSNP
rs533643051 1090 dbSNP
rs767694787 1092 dbSNP
rs1031465124 1099 dbSNP
rs1270221823 1102 dbSNP
rs892584012 1103 dbSNP
rs530762984 1107 dbSNP
rs1279698176 1109 dbSNP
rs367614489 1114 dbSNP
rs1231587684 1115 dbSNP
rs1344576892 1118 dbSNP
rs1293902048 1119 dbSNP
rs1459343913 1121 dbSNP
rs1274450265 1122 dbSNP
rs1465140356 1124 dbSNP
rs1424505406 1126 dbSNP
rs1196099201 1128 dbSNP
rs1479586211 1134 dbSNP
rs867904909 1141 dbSNP
rs1192166194 1144 dbSNP
rs1489724325 1155 dbSNP
rs1231645262 1165 dbSNP
rs184653314 1166 dbSNP
rs934707405 1172 dbSNP
rs1272581269 1192 dbSNP
rs558629854 1198 dbSNP
rs1322436954 1229 dbSNP
rs1388274711 1245 dbSNP
rs1028589499 1250 dbSNP
rs1447495630 1258 dbSNP
rs756456098 1263 dbSNP
rs952957182 1266 dbSNP
rs778443160 1267 dbSNP
rs1177114577 1272 dbSNP
rs984737349 1286 dbSNP
rs1449614760 1287 dbSNP
rs1197927236 1288 dbSNP
rs917372303 1289 dbSNP
rs1458612397 1302 dbSNP
rs1239426881 1303 dbSNP
rs570932075 1309 dbSNP
rs1450945360 1310 dbSNP
rs1166397743 1313 dbSNP
rs189427997 1327 dbSNP
rs961447944 1329 dbSNP
rs992573171 1337 dbSNP
rs1389000855 1344 dbSNP
rs916975010 1349 dbSNP
rs948402121 1353 dbSNP
rs1164744280 1360 dbSNP
rs764378203 1365 dbSNP
rs34882908 1367 dbSNP
rs1308276256 1371 dbSNP
rs754243903 1373 dbSNP
rs905750894 1378 dbSNP
rs541773408 1390 dbSNP
rs757656799 1393 dbSNP
rs1049334050 1396 dbSNP
rs1467789776 1399 dbSNP
rs1158455860 1440 dbSNP
rs182204054 1441 dbSNP
rs1382678773 1443 dbSNP
rs1295736471 1445 dbSNP
rs1182335896 1454 dbSNP
rs1004714906 1471 dbSNP
rs372559137 1482 dbSNP
rs901630890 1486 dbSNP
rs891611010 1488 dbSNP
rs1284991414 1490 dbSNP
rs1217087271 1499 dbSNP
rs1355645043 1503 dbSNP
rs1312789190 1511 dbSNP
rs995781321 1512 dbSNP
rs779505990 1520 dbSNP
rs954412460 1538 dbSNP
rs1354181005 1539 dbSNP
rs1397969106 1545 dbSNP
rs1383105675 1549 dbSNP
rs1208948166 1550 dbSNP
rs374053277 1565 dbSNP
rs979045649 1569 dbSNP
rs1041167884 1576 dbSNP
rs541162646 1577 dbSNP
rs1189054660 1579 dbSNP
rs1426312255 1583 dbSNP
rs111858017 1594 dbSNP
rs901225533 1598 dbSNP
rs1186258198 1604 dbSNP
rs1247074579 1618 dbSNP
rs564632056 1620 dbSNP
rs1208384403 1622 dbSNP
rs1489144836 1625 dbSNP
rs996854601 1627 dbSNP
rs1370649775 1628 dbSNP
rs917319833 1638 dbSNP
rs746474413 1639 dbSNP
rs950130375 1642 dbSNP
rs1338572150 1643 dbSNP
rs1277802754 1644 dbSNP
rs1400904523 1646 dbSNP
rs1389827812 1651 dbSNP
rs980068432 1656 dbSNP
rs144563855 1657 dbSNP
rs1392109377 1659 dbSNP
rs1318734691 1662 dbSNP
rs546001875 1663 dbSNP
rs1453386690 1667 dbSNP
rs1170879341 1669 dbSNP
rs930514448 1676 dbSNP
rs1314946746 1683 dbSNP
rs1048971901 1691 dbSNP
rs1243959749 1702 dbSNP
rs886391145 1710 dbSNP
rs148004038 1714 dbSNP
rs1316133463 1718 dbSNP
rs1257517034 1720 dbSNP
rs1219408064 1722 dbSNP
rs1040208700 1725 dbSNP
rs7092702 1730 dbSNP
rs1332077754 1738 dbSNP
rs1326099782 1739 dbSNP
rs7076705 1745 dbSNP
rs1398840774 1749 dbSNP
rs992929620 1750 dbSNP
rs1331480647 1753 dbSNP
rs1029042508 1754 dbSNP
rs1422598353 1758 dbSNP
rs773080700 1759 dbSNP
rs1461505031 1762 dbSNP
rs1379212828 1769 dbSNP
rs368620011 1778 dbSNP
rs1179501755 1785 dbSNP
rs1457264946 1795 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions Hela
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1048187. RNA binding protein: AGO2. Condition:Hela_AGO2_CLIP_control ...

- Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al., 2013, Cell.

Article - Xue Y; Ouyang K; Huang J; Zhou Y; Ouyang H; et al.
- Cell, 2013
The induction of pluripotency or trans-differentiation of one cell type to another can be accomplished with cell-lineage-specific transcription factors. Here, we report that repression of a single RNA binding polypyrimidine-tract-binding (PTB) protein, which occurs during normal brain development via the action of miR-124, is sufficient to induce trans-differentiation of fibroblasts into functional neurons. Besides its traditional role in regulated splicing, we show that PTB has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure. A key event during neuronal induction is the relief of PTB-mediated blockage of microRNA action on multiple components of the REST complex, thereby derepressing a large array of neuronal genes, including miR-124 and multiple neuronal-specific transcription factors, in nonneuronal cells. This converts a negative feedback loop to a positive one to elicit cellular reprogramming to the neuronal lineage.
LinkOut: [PMID: 23313552]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760639. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP-MDV_A ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' accgacuuucugguUUCUUGUu 5'
                        ||||||| 
Target 5' uguggauuuuucgcAAGAACAu 3'
 		12 - 33
Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM1048187
Method / RBP HITS-CLIP / AGO2
Cell line / Condition Hela / Hela_AGO2_CLIP_control
Location of target site ENST00000435275.1 | 3UTR | GGAGAUUGGAUCACAGccgaaggaguaaAGGUGCUGCAAUGAUGUUAGCUGUGGCCACUGUGGAUUUUUCGCAAGA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23313552 / GSE42701
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
84 hsa-miR-4677-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT080553 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 2
MIRT089446 STAMBP STAM binding protein 2 2
MIRT135057 ADSS adenylosuccinate synthase 2 4
MIRT263519 RPS24 ribosomal protein S24 2 2
MIRT357966 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT384298 GOLT1B golgi transport 1B 2 2
MIRT407003 CEBPB CCAAT/enhancer binding protein beta 2 2
MIRT442312 UBE2Q1 ubiquitin conjugating enzyme E2 Q1 2 2
MIRT443782 ST13 ST13, Hsp70 interacting protein 2 2
MIRT446864 NBPF3 NBPF member 3 2 2
MIRT447642 RAB3GAP1 RAB3 GTPase activating protein catalytic subunit 1 2 2
MIRT448464 SLC45A4 solute carrier family 45 member 4 2 2
MIRT449117 XRRA1 X-ray radiation resistance associated 1 2 2
MIRT450240 TRIM66 tripartite motif containing 66 2 2
MIRT450265 F2RL2 coagulation factor II thrombin receptor like 2 2 2
MIRT450682 RPN2 ribophorin II 2 2
MIRT465594 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT481118 AZIN1 antizyme inhibitor 1 2 4
MIRT497203 CDH7 cadherin 7 2 4
MIRT502954 CCNT2 cyclin T2 2 2
MIRT506337 NUP54 nucleoporin 54 2 4
MIRT509224 KIF14 kinesin family member 14 2 6
MIRT514595 NDUFA12 NADH:ubiquinone oxidoreductase subunit A12 2 4
MIRT515392 ARHGAP21 Rho GTPase activating protein 21 2 4
MIRT525555 MTRNR2L7 MT-RNR2-like 7 2 6
MIRT525604 MTRNR2L3 MT-RNR2-like 3 2 4
MIRT533249 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT535778 MTRNR2L11 MT-RNR2-like 11 2 6
MIRT535799 MTRNR2L10 MT-RNR2-like 10 2 4
MIRT552784 YAF2 YY1 associated factor 2 2 2
MIRT556213 MB21D2 Mab-21 domain containing 2 2 2
MIRT558192 EIF2S1 eukaryotic translation initiation factor 2 subunit alpha 2 4
MIRT565809 SDCCAG3 serologically defined colon cancer antigen 3 2 2
MIRT566341 POLDIP2 DNA polymerase delta interacting protein 2 2 2
MIRT567792 DEK DEK proto-oncogene 2 2
MIRT572455 ZNF516 zinc finger protein 516 2 2
MIRT572582 HGFAC HGF activator 2 2
MIRT573357 PDE3A phosphodiesterase 3A 2 2
MIRT574649 LMAN2 lectin, mannose binding 2 2 2
MIRT608164 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT610690 FAM89A family with sequence similarity 89 member A 2 2
MIRT618457 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT621924 SYAP1 synapse associated protein 1 2 4
MIRT622279 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT624610 B3GALT5 beta-1,3-galactosyltransferase 5 2 2
MIRT631040 TAS2R30 taste 2 receptor member 30 2 2
MIRT636153 TRPS1 transcriptional repressor GATA binding 1 2 2
MIRT638255 SIX1 SIX homeobox 1 2 2
MIRT638330 RCAN1 regulator of calcineurin 1 2 2
MIRT641621 KIAA1244 ARFGEF family member 3 3 3
MIRT644556 SPOP speckle type BTB/POZ protein 2 2
MIRT645900 LRIF1 ligand dependent nuclear receptor interacting factor 1 2 2
MIRT649115 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT652244 TPI1 triosephosphate isomerase 1 2 2
MIRT657249 ICOSLG inducible T-cell costimulator ligand 2 2
MIRT659857 CAPRIN1 cell cycle associated protein 1 2 4
MIRT665369 XIAP X-linked inhibitor of apoptosis 2 2
MIRT669214 CAND1 cullin associated and neddylation dissociated 1 2 2
MIRT682579 CPA4 carboxypeptidase A4 2 2
MIRT698725 STX6 syntaxin 6 2 4
MIRT699788 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT700290 RABGEF1 RAB guanine nucleotide exchange factor 1 2 2
MIRT710374 LMBR1 limb development membrane protein 1 2 2
MIRT710407 YTHDC1 YTH domain containing 1 2 2
MIRT710569 TNPO1 transportin 1 2 2
MIRT711384 PLEKHG4B pleckstrin homology and RhoGEF domain containing G4B 2 2
MIRT712042 STYK1 serine/threonine/tyrosine kinase 1 2 2
MIRT712717 NCAPG2 non-SMC condensin II complex subunit G2 2 2
MIRT713288 ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif 20 2 2
MIRT715649 USP6NL USP6 N-terminal like 2 2
MIRT716167 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT716756 TRABD2A TraB domain containing 2A 2 2
MIRT718209 TNRC6C trinucleotide repeat containing 6C 2 2
MIRT718361 SOX1 SRY-box 1 2 2
MIRT718806 SLC25A33 solute carrier family 25 member 33 2 2
MIRT719339 VGLL4 vestigial like family member 4 2 2
MIRT719671 SPDYE1 speedy/RINGO cell cycle regulator family member E1 2 2
MIRT720827 C1orf52 chromosome 1 open reading frame 52 2 2
MIRT722184 DNAJC9 DnaJ heat shock protein family (Hsp40) member C9 2 2
MIRT722398 BCAS2 BCAS2, pre-mRNA processing factor 2 2
MIRT723460 ST8SIA3 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 3 2 2
MIRT724072 NCKAP1L NCK associated protein 1 like 2 2
MIRT724594 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
MIRT725234 PDE1B phosphodiesterase 1B 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4677 Doxorubicin 31703 NSC123127 approved resistant High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-mir-4677 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-4677 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-4677-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-4677-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4677-5p Platinum 23939 sensitive tissue (non-small cell lung cancer)
hsa-miR-4677-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM16)
hsa-miR-4677-5p Neoadjuvant chemotherapy resistant tissue (breast cancer)

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