miRTarBase - #MIRT263546


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pre-miRNA Information
pre-miRNA hsa-mir-4476   
Genomic Coordinates chr9: 36893462 - 36893531
Description Homo sapiens miR-4476 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4476
Sequence 45| CAGGAAGGAUUUAGGGACAGGC |66
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 6 9 - 36893482 29233923 MiREDiBase
A-to-I 9 9 - 36893479 29233923 MiREDiBase
A-to-I 13 9 - 36893475 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs978640498 3 dbSNP
rs1019792440 6 dbSNP
rs1008364367 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol PPIF   
Synonyms CYP3, CyP-M, Cyp-D, CypD
Description peptidylprolyl isomerase F
Transcript NM_005729   
Expression
Putative miRNA Targets on PPIF
3'UTR of PPIF
(miRNA target sites are highlighted)		 
>PPIF|NM_005729|3'UTR
   1 TCTGTGGCCAGGGTGCTGGCATGGTGGCAGCTGCAAATGTCCATGCACCCAGGTGGCCGCGTTGGGCTGTCAGCCAAGGT
  81 GCCTGAAACGATACGTGTGCCCACTCCACTGTCACAGTGTGCCTGAGGAAGGCTGCTAGGGATGTTAGACCTCGGCCAGG
 161 ACCCACCACATTGCTTCCTAATACCCACCCTTCCTCACGACCTCATTTCTGGGCATCTTTGTGGACATGATGTCACCCAC
 241 CCCTTGTCAAGCATTGCCTGTGATTGCCCAGCCCAGATTCATCTGTGCCTTGGACATGGTGATGGTGATGGGTTGCCATC
 321 CAAGTGAAAGTCTTTTCCTTGACCAAGGGGGACAGTCAGTTTTGCAAAAGGACTCTAATACCTGTTTAATATTGTCTTCC
 401 TAATTGGGATAATTTAATTAACAAGATTGACTAGAAGTGAAACTGCAACACTAACTTCCCCGTGCTGTGGTGTGACCTGA
 481 GTTGGTGACACAGGCCACAGACCCCAGAGCTTGGCTTTTGAAACACAACTCAGGGCTTTTGTGAAGGTTCCCCCGCTGAG
 561 ATCTTTCCTCCTGGTTACTGTGAAGCCTGTTGGTTTGCTGCTGTCGTTTTTGAGGAGGGCCCATGGGGGTAGGAGCAGTT
 641 GAACCTGGGAACAAACCTCACTTGAGCTGTGCCTAGACAATGTGAATTCCTGTGTTGCTAACAGAAGTGGCCTGTAAGCT
 721 CCTGTGCTCCGGAGGGAAGCATTTCCTGGTAGGCTTTGATTTTTCTGTGTGTTAAAGAAATTCAATCTACTCATGATGTG
 801 TTATGCATAAAACATTTCTGGAACATGGATTTGTGTTCACCTTAAATGTGAAAATAAATCCTATTTTCTATGGAAGACTG
 881 GTACCTGGTTTCTGGAAGAGGGGTCTGTGACTTGGAGCTGATCTTTACTGAGCTCGCCGTGGCAGATGCCATGCTCAGGA
 961 CGTTCATGTGGATGGTTTCATGTCATCGTGCTGGCAACTTGTCCTCCCTGCCTTAGAGATGAGGCTCAGACAAACGACCT
1041 TAGCACCCATAGCCTATGCCATGAGCACTGGCTCCACCCTGAATCCCAGCTCCTCCCCTTAGTGACCCCAAGTCTGTTTC
1121 CCTCAGCTGCATAAGGAGGCGATATAGTTTGAATATTTGTCCCCAGCCAAATCTCATGTTGAACTGTAATCCCCAGTGCT
1201 GGAGGTGGGGCCTGCTACGAGGTGTTTGGATCATGGGGACGGGTATTTCATGGCTTGGTGCTGTTTTCTTGATGGTGAAT
1281 TATTGCAAGATACGGTCATTTAAAATTGTGTGGCACCTCCCCCTGCCCCCTTCTTGCTCCTGCTTTCACCATGTGACATG
1361 CCTGATCCCCCTTCACCTTTTGCCATGGTCATAAGCTTCCTGAGGCCTCCCTGGAAGCTGAGCAGATGCCAGCACCATGC
1441 TTCCTGTACATCCTGCAGAACCATAAGCCAATTAAACCTTTTTAATAATAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgGAC-AGGGAUU-----UAGGAAGGAc 5'
            :|| |:|||||     | ||||||| 
Target 5' caTTGCTTCCTAATACCCACCCTTCCTc 3'
 169 - 196 160.00 -16.10
2 
miRNA  3' cggacaGGGA-UUUAGGAAGGAc 5'
                | || |:|||:||||| 
Target 5' ttccccCGCTGAGATCTTTCCTc 3'
 548 - 570 144.00 -17.00
3 
miRNA  3' cgGACAGGGAUU-UA--GGAAGGAc 5'
            ||||  :||| ||  :|||||| 
Target 5' acCTGT--TTAATATTGTCTTCCTa 3'
 380 - 402 142.00 -17.52
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30526368 7 COSMIC
COSN31560084 17 COSMIC
COSN30509323 42 COSMIC
COSN30461972 59 COSMIC
COSN30133953 61 COSMIC
COSN30112251 91 COSMIC
COSN30170017 127 COSMIC
COSN31538521 160 COSMIC
COSN31566353 200 COSMIC
COSN27522198 205 COSMIC
COSN28804949 218 COSMIC
COSN8640529 253 COSMIC
COSN31532246 260 COSMIC
COSN19659142 459 COSMIC
COSN19659143 460 COSMIC
COSN20486310 463 COSMIC
COSN26642575 594 COSMIC
COSN26551635 598 COSMIC
COSN31541914 698 COSMIC
COSN31490417 805 COSMIC
COSN31607615 824 COSMIC
COSN8721879 888 COSMIC
rs7332 463 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1441146351 1 dbSNP
rs1253193720 3 dbSNP
rs892438334 4 dbSNP
rs772627956 5 dbSNP
rs1424294979 11 dbSNP
rs762914987 14 dbSNP
rs530730945 27 dbSNP
rs1318670814 38 dbSNP
rs1361505709 40 dbSNP
rs751383371 43 dbSNP
rs1250077801 45 dbSNP
rs895342757 50 dbSNP
rs376682545 51 dbSNP
rs1000613949 59 dbSNP
rs188222825 60 dbSNP
rs1244138333 61 dbSNP
rs1397739122 62 dbSNP
rs561141770 63 dbSNP
rs1299516037 71 dbSNP
rs765036683 82 dbSNP
rs1295148337 85 dbSNP
rs1007876657 90 dbSNP
rs1326439067 91 dbSNP
rs1161130822 92 dbSNP
rs1421185267 94 dbSNP
rs529848344 95 dbSNP
rs1447987706 96 dbSNP
rs553861039 104 dbSNP
rs1418825559 107 dbSNP
rs2230225 108 dbSNP
rs774050677 114 dbSNP
rs1268316916 115 dbSNP
rs996811021 119 dbSNP
rs1220319637 131 dbSNP
rs1247223845 133 dbSNP
rs532215710 154 dbSNP
rs1261490949 155 dbSNP
rs952571744 162 dbSNP
rs1314851780 165 dbSNP
rs982817439 166 dbSNP
rs1284945916 168 dbSNP
rs971688018 179 dbSNP
rs1405553874 185 dbSNP
rs754456742 189 dbSNP
rs908605390 191 dbSNP
rs960133067 194 dbSNP
rs552215672 198 dbSNP
rs992749259 199 dbSNP
rs1385264608 200 dbSNP
rs1157568051 215 dbSNP
rs753121 218 dbSNP
rs763133711 228 dbSNP
rs538540674 233 dbSNP
rs889242086 234 dbSNP
rs535150575 235 dbSNP
rs1441873127 237 dbSNP
rs944995509 239 dbSNP
rs948977346 243 dbSNP
rs568678017 244 dbSNP
rs149485754 247 dbSNP
rs1204835750 254 dbSNP
rs1235711830 259 dbSNP
rs1264818938 278 dbSNP
rs1223877838 290 dbSNP
rs1322763244 291 dbSNP
rs1281263012 294 dbSNP
rs752341402 297 dbSNP
rs934842602 300 dbSNP
rs1326558670 302 dbSNP
rs1164043564 303 dbSNP
rs556570366 305 dbSNP
rs1009593015 311 dbSNP
rs1053292278 312 dbSNP
rs554270251 313 dbSNP
rs1470483685 319 dbSNP
rs1429203547 327 dbSNP
rs117391830 330 dbSNP
rs1476667168 354 dbSNP
rs1373786044 364 dbSNP
rs545859012 368 dbSNP
rs777521085 372 dbSNP
rs1002250475 375 dbSNP
rs1204099604 376 dbSNP
rs1460657575 376 dbSNP
rs556150349 379 dbSNP
rs1034202458 385 dbSNP
rs958758157 390 dbSNP
rs192435302 395 dbSNP
rs544150041 405 dbSNP
rs1315230918 417 dbSNP
rs561018996 417 dbSNP
rs1026934671 429 dbSNP
rs888376456 431 dbSNP
rs1342851609 434 dbSNP
rs11002941 436 dbSNP
rs1412170708 437 dbSNP
rs1397810996 438 dbSNP
rs374252110 439 dbSNP
rs1015383714 444 dbSNP
rs960079304 446 dbSNP
rs879931723 452 dbSNP
rs1184383814 453 dbSNP
rs1444226545 460 dbSNP
rs7332 463 dbSNP
rs1183690596 466 dbSNP
rs183687846 471 dbSNP
rs1193576796 488 dbSNP
rs1261481702 488 dbSNP
rs532252443 489 dbSNP
rs1291853470 508 dbSNP
rs970105851 514 dbSNP
rs1282845388 520 dbSNP
rs1444756053 527 dbSNP
rs979409153 533 dbSNP
rs1328698097 536 dbSNP
rs116197316 549 dbSNP
rs934904923 553 dbSNP
rs1424313771 555 dbSNP
rs1462640350 555 dbSNP
rs528294465 556 dbSNP
rs914174689 559 dbSNP
rs1184059709 568 dbSNP
rs945578051 569 dbSNP
rs551262617 571 dbSNP
rs76010993 572 dbSNP
rs1490819027 605 dbSNP
rs113929717 607 dbSNP
rs1040824457 609 dbSNP
rs1002304546 610 dbSNP
rs114235114 613 dbSNP
rs187956293 625 dbSNP
rs1285831792 629 dbSNP
rs534478855 630 dbSNP
rs1477490508 631 dbSNP
rs547690789 633 dbSNP
rs1014544330 645 dbSNP
rs1279310443 646 dbSNP
rs1470590627 648 dbSNP
rs1024132754 650 dbSNP
rs1331216061 667 dbSNP
rs778167161 669 dbSNP
rs1048554587 670 dbSNP
rs1404342516 672 dbSNP
rs781005353 681 dbSNP
rs1004094138 692 dbSNP
rs951685906 695 dbSNP
rs1449524977 698 dbSNP
rs985746511 702 dbSNP
rs910315630 705 dbSNP
rs1015372369 716 dbSNP
rs749680632 725 dbSNP
rs965820056 727 dbSNP
rs1014734147 728 dbSNP
rs1487194454 730 dbSNP
rs758107853 731 dbSNP
rs143853873 732 dbSNP
rs1446029679 736 dbSNP
rs1284085901 747 dbSNP
rs1226884976 749 dbSNP
rs745876572 772 dbSNP
rs945630373 774 dbSNP
rs1223010020 777 dbSNP
rs539551534 778 dbSNP
rs1365645489 786 dbSNP
rs1043972548 793 dbSNP
rs556238151 800 dbSNP
rs74142395 801 dbSNP
rs1344817567 805 dbSNP
rs570394795 809 dbSNP
rs978759598 810 dbSNP
rs1406771379 812 dbSNP
rs1175555253 814 dbSNP
rs769106475 815 dbSNP
rs1055132770 817 dbSNP
rs1058740 819 dbSNP
rs1186583764 826 dbSNP
rs1474887331 827 dbSNP
rs1432249322 834 dbSNP
rs1245752492 837 dbSNP
rs1207261827 839 dbSNP
rs1033020134 841 dbSNP
rs1264120444 846 dbSNP
rs1203631314 861 dbSNP
rs1310951794 864 dbSNP
rs1297890202 871 dbSNP
rs1215177486 875 dbSNP
rs768237535 895 dbSNP
rs896599133 899 dbSNP
rs74142396 910 dbSNP
rs1454395598 917 dbSNP
rs989102842 922 dbSNP
rs1169315580 933 dbSNP
rs75781151 936 dbSNP
rs574657401 937 dbSNP
rs975330587 939 dbSNP
rs920999653 940 dbSNP
rs932396812 945 dbSNP
rs1299154906 949 dbSNP
rs1390392730 952 dbSNP
rs748099053 957 dbSNP
rs1385344749 961 dbSNP
rs878857894 962 dbSNP
rs1482569966 973 dbSNP
rs540479368 981 dbSNP
rs909586485 982 dbSNP
rs1346369050 988 dbSNP
rs1248489584 989 dbSNP
rs1017237503 1006 dbSNP
rs1314132654 1016 dbSNP
rs966190593 1020 dbSNP
rs1375487511 1027 dbSNP
rs560092095 1031 dbSNP
rs866234044 1036 dbSNP
rs1368210473 1037 dbSNP
rs1276381288 1040 dbSNP
rs1316056172 1042 dbSNP
rs975834220 1044 dbSNP
rs1384158392 1048 dbSNP
rs550587611 1070 dbSNP
rs1422391233 1079 dbSNP
rs577108161 1086 dbSNP
rs1270909290 1087 dbSNP
rs1207724463 1090 dbSNP
rs1249792903 1094 dbSNP
rs545960612 1103 dbSNP
rs895638532 1108 dbSNP
rs1360450276 1113 dbSNP
rs1265047499 1119 dbSNP
rs1242373485 1134 dbSNP
rs59038032 1137 dbSNP
rs1044636816 1141 dbSNP
rs905915090 1142 dbSNP
rs749501273 1152 dbSNP
rs1033011187 1169 dbSNP
rs373082055 1175 dbSNP
rs938238260 1177 dbSNP
rs1430819616 1187 dbSNP
rs531363186 1196 dbSNP
rs1368278798 1197 dbSNP
rs762795518 1200 dbSNP
rs1365951867 1202 dbSNP
rs1160278475 1206 dbSNP
rs192387497 1214 dbSNP
rs8837 1216 dbSNP
rs57510738 1219 dbSNP
rs1208330514 1223 dbSNP
rs1486971013 1230 dbSNP
rs142445267 1237 dbSNP
rs974900118 1239 dbSNP
rs73307964 1241 dbSNP
rs184556662 1242 dbSNP
rs151334735 1251 dbSNP
rs761238737 1253 dbSNP
rs1330052150 1262 dbSNP
rs1298515258 1263 dbSNP
rs569834379 1270 dbSNP
rs1321025880 1272 dbSNP
rs1383627482 1273 dbSNP
rs1385203789 1274 dbSNP
rs1289829454 1279 dbSNP
rs1457011787 1289 dbSNP
rs1242391702 1290 dbSNP
rs939716131 1294 dbSNP
rs1007437912 1295 dbSNP
rs1377208402 1312 dbSNP
rs1196829114 1314 dbSNP
rs1430536352 1319 dbSNP
rs1262610221 1324 dbSNP
rs1017708143 1326 dbSNP
rs1463337896 1330 dbSNP
rs1264746152 1331 dbSNP
rs1204265963 1341 dbSNP
rs901481029 1357 dbSNP
rs7898 1362 dbSNP
rs1228894423 1365 dbSNP
rs1326693199 1375 dbSNP
rs1296359420 1376 dbSNP
rs1432421588 1383 dbSNP
rs917148022 1385 dbSNP
rs950009249 1393 dbSNP
rs1044230761 1395 dbSNP
rs1339103308 1397 dbSNP
rs1020741944 1403 dbSNP
rs12779059 1407 dbSNP
rs1000269118 1409 dbSNP
rs1170900222 1419 dbSNP
rs1463554321 1422 dbSNP
rs1373880605 1428 dbSNP
rs979632241 1438 dbSNP
rs190187167 1446 dbSNP
rs1186575356 1447 dbSNP
rs139685091 1451 dbSNP
rs1183954658 1453 dbSNP
rs1422581300 1458 dbSNP
rs1441780165 1463 dbSNP
rs1253907195 1478 dbSNP
rs533887284 1479 dbSNP
rs991062585 1480 dbSNP
rs1273246538 1488 dbSNP
rs1225812040 1489 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cggacagGGAUU-UA--GGAAGGAc 5'
                 ::||| ||  :|||||| 
Target 5' -------UUUAAUAUUGUCUUCCUa 3'
 		1 - 18
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 10105.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cggacagGGAUU-UA--GGAAGGAc 5'
                 ::||| ||  :|||||| 
Target 5' -------UUUAAUAUUGUCUUCCUa 3'
 		1 - 18
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000225174.3 | 3UTR | UUUAAUAUUGUCUUCCUAAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000225174.3 | 3UTR | UUUAAUAUUGUCUUCCUAAUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
152 hsa-miR-4476 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT065631 CLIC4 chloride intracellular channel 4 2 2
MIRT076187 GID4 GID complex subunit 4 homolog 2 4
MIRT086304 HOXD8 homeobox D8 2 6
MIRT110644 ARID5B AT-rich interaction domain 5B 2 2
MIRT144337 NFAT5 nuclear factor of activated T-cells 5 2 2
MIRT196634 TAOK1 TAO kinase 1 2 6
MIRT227655 SET SET nuclear proto-oncogene 2 2
MIRT263546 PPIF peptidylprolyl isomerase F 2 4
MIRT266189 TXNIP thioredoxin interacting protein 2 4
MIRT266815 SLC25A44 solute carrier family 25 member 44 2 2
MIRT285538 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT295094 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT300906 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT304110 CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 2 6
MIRT314891 RGMB repulsive guidance molecule family member b 2 2
MIRT364225 ANP32B acidic nuclear phosphoprotein 32 family member B 2 2
MIRT366237 VMA21 VMA21, vacuolar ATPase assembly factor 2 2
MIRT405440 RAB5B RAB5B, member RAS oncogene family 2 2
MIRT443613 OR2D2 olfactory receptor family 2 subfamily D member 2 2 2
MIRT445947 SCML4 Scm polycomb group protein like 4 2 2
MIRT445957 MLLT11 MLLT11, transcription factor 7 cofactor 2 2
MIRT445970 IKZF5 IKAROS family zinc finger 5 2 2
MIRT448066 MMP15 matrix metallopeptidase 15 2 2
MIRT449498 ZBTB4 zinc finger and BTB domain containing 4 2 2
MIRT450831 IFFO1 intermediate filament family orphan 1 2 2
MIRT451270 NDUFA11 NADH:ubiquinone oxidoreductase subunit A11 2 2
MIRT451318 LGALS3BP galectin 3 binding protein 2 2
MIRT451403 FARSA phenylalanyl-tRNA synthetase alpha subunit 2 2
MIRT451941 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT452028 NLRP6 NLR family pyrin domain containing 6 2 2
MIRT452503 HMGXB3 HMG-box containing 3 2 2
MIRT453852 SDK1 sidekick cell adhesion molecule 1 2 2
MIRT454523 ZFYVE27 zinc finger FYVE-type containing 27 2 2
MIRT455402 PLA2G2F phospholipase A2 group IIF 2 2
MIRT455442 ID3 inhibitor of DNA binding 3, HLH protein 2 2
MIRT456983 MANEA mannosidase endo-alpha 2 2
MIRT457610 IDS iduronate 2-sulfatase 2 2
MIRT458319 TNFAIP8L3 TNF alpha induced protein 8 like 3 2 2
MIRT458756 CES2 carboxylesterase 2 2 2
MIRT458960 SAMD4B sterile alpha motif domain containing 4B 2 2
MIRT460403 GPHA2 glycoprotein hormone alpha 2 2 2
MIRT460632 IGFBP4 insulin like growth factor binding protein 4 2 2
MIRT461760 DDX11 DEAD/H-box helicase 11 2 2
MIRT461924 NECAB3 N-terminal EF-hand calcium binding protein 3 2 2
MIRT461977 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT462271 TPI1 triosephosphate isomerase 1 2 2
MIRT462304 PPM1H protein phosphatase, Mg2+/Mn2+ dependent 1H 2 2
MIRT462725 SEMA4G semaphorin 4G 2 2
MIRT463414 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT463525 ZBTB7B zinc finger and BTB domain containing 7B 2 2
MIRT464089 VPS4A vacuolar protein sorting 4 homolog A 2 2
MIRT464623 UBE4B ubiquitination factor E4B 2 2
MIRT465030 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT465562 TOB2 transducer of ERBB2, 2 2 2
MIRT465890 TMEM43 transmembrane protein 43 2 2
MIRT466428 TFAP2A transcription factor AP-2 alpha 2 8
MIRT466593 TBC1D2B TBC1 domain family member 2B 2 2
MIRT467623 SLC7A5 solute carrier family 7 member 5 2 2
MIRT468511 SESN2 sestrin 2 2 2
MIRT468649 SEH1L SEH1 like nucleoporin 2 2
MIRT468737 SDC4 syndecan 4 2 2
MIRT468752 SDC2 syndecan 2 2 2
MIRT469182 RNF111 ring finger protein 111 2 2
MIRT469476 REEP5 receptor accessory protein 5 2 2
MIRT472078 NOVA2 NOVA alternative splicing regulator 2 2 2
MIRT472093 NOLC1 nucleolar and coiled-body phosphoprotein 1 2 2
MIRT472194 NHP2L1 small nuclear ribonucleoprotein 13 2 2
MIRT472453 NAV2 neuron navigator 2 2 6
MIRT474493 KLHDC8B kelch domain containing 8B 2 2
MIRT475174 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT475350 IFNLR1 interferon lambda receptor 1 2 2
MIRT476474 GATAD2B GATA zinc finger domain containing 2B 2 2
MIRT477094 FAM168A family with sequence similarity 168 member A 2 2
MIRT477179 F3 coagulation factor III, tissue factor 2 6
MIRT478026 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT479587 CDC42SE1 CDC42 small effector 1 2 2
MIRT480117 CALR calreticulin 2 2
MIRT480465 C11orf84 chromosome 11 open reading frame 84 2 2
MIRT480803 BLOC1S2 biogenesis of lysosomal organelles complex 1 subunit 2 2 6
MIRT481076 B4GALT1 beta-1,4-galactosyltransferase 1 2 2
MIRT482576 ABHD2 abhydrolase domain containing 2 2 2
MIRT482690 NXN nucleoredoxin 2 4
MIRT483599 SLC26A9 solute carrier family 26 member 9 2 2
MIRT485011 TNRC6B trinucleotide repeat containing 6B 2 4
MIRT488051 PABPC1L2B poly(A) binding protein cytoplasmic 1 like 2B 2 2
MIRT488067 PABPC1L2A poly(A) binding protein cytoplasmic 1 like 2A 2 2
MIRT488176 PRRC2B proline rich coiled-coil 2B 2 4
MIRT488859 UBTF upstream binding transcription factor, RNA polymerase I 2 2
MIRT489074 STARD3 StAR related lipid transfer domain containing 3 2 2
MIRT489181 ANKRD45 ankyrin repeat domain 45 2 2
MIRT489981 DDB1 damage specific DNA binding protein 1 2 2
MIRT490225 WRN Werner syndrome RecQ like helicase 2 2
MIRT491084 HILPDA hypoxia inducible lipid droplet associated 2 2
MIRT491540 HDAC5 histone deacetylase 5 2 2
MIRT492540 PSMD11 proteasome 26S subunit, non-ATPase 11 2 2
MIRT499034 MAG myelin associated glycoprotein 2 2
MIRT499420 PLCG2 phospholipase C gamma 2 2 4
MIRT499820 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT500046 SDE2 SDE2 telomere maintenance homolog 2 6
MIRT500844 SYPL1 synaptophysin like 1 2 4
MIRT504518 PPP1R9B protein phosphatase 1 regulatory subunit 9B 2 2
MIRT505622 SLC25A37 solute carrier family 25 member 37 2 2
MIRT509134 STK4 serine/threonine kinase 4 2 2
MIRT509219 BUB3 BUB3, mitotic checkpoint protein 2 4
MIRT510752 SLC7A1 solute carrier family 7 member 1 2 2
MIRT512115 CREBZF CREB/ATF bZIP transcription factor 2 2
MIRT512317 ACTR2 ARP2 actin related protein 2 homolog 2 6
MIRT517395 BGN biglycan 2 4
MIRT518412 SSU72 SSU72 homolog, RNA polymerase II CTD phosphatase 2 4
MIRT521362 RPL35A ribosomal protein L35a 2 2
MIRT525072 FRK fyn related Src family tyrosine kinase 2 2
MIRT525800 SOD2 superoxide dismutase 2 2 2
MIRT530430 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT541467 AURKA aurora kinase A 2 2
MIRT544303 TSPYL1 TSPY like 1 2 2
MIRT546415 SPRED3 sprouty related EVH1 domain containing 3 2 2
MIRT546582 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT548764 CNN3 calponin 3 2 2
MIRT549809 KIAA0391 KIAA0391 2 2
MIRT550611 MTHFR methylenetetrahydrofolate reductase 2 2
MIRT552227 FIG4 FIG4 phosphoinositide 5-phosphatase 2 4
MIRT554008 SPTLC1 serine palmitoyltransferase long chain base subunit 1 2 2
MIRT554116 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT555100 PURB purine rich element binding protein B 2 2
MIRT560290 HRH2 histamine receptor H2 2 2
MIRT560381 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT560800 EPM2AIP1 EPM2A interacting protein 1 2 2
MIRT560978 IWS1 IWS1, SUPT6H interacting protein 2 2
MIRT561161 BCL2L12 BCL2 like 12 2 2
MIRT562389 EN2 engrailed homeobox 2 2 2
MIRT562482 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT567784 DGAT2 diacylglycerol O-acyltransferase 2 2 2
MIRT568831 TRIM67 tripartite motif containing 67 2 2
MIRT569555 UNC119B unc-119 lipid binding chaperone B 2 2
MIRT572382 ATOX1 antioxidant 1 copper chaperone 2 2
MIRT575792 Tnfrsf10b tumor necrosis factor receptor superfamily, member 10b 2 2
MIRT610505 CTBS chitobiase 2 4
MIRT616605 PAPD5 poly(A) RNA polymerase D5, non-canonical 2 2
MIRT621780 TMEM87B transmembrane protein 87B 2 2
MIRT634217 TMEM192 transmembrane protein 192 2 2
MIRT639651 WHAMM WAS protein homolog associated with actin, golgi membranes and microtubules 2 2
MIRT642500 ALDOA aldolase, fructose-bisphosphate A 2 2
MIRT643217 TYW3 tRNA-yW synthesizing protein 3 homolog 2 4
MIRT674822 KCNJ10 potassium voltage-gated channel subfamily J member 10 2 2
MIRT697356 ZNF426 zinc finger protein 426 2 2
MIRT704675 CHTOP chromatin target of PRMT1 2 2
MIRT708704 TFDP2 transcription factor Dp-2 2 2
MIRT709660 DFFB DNA fragmentation factor subunit beta 2 2
MIRT711280 SDR9C7 short chain dehydrogenase/reductase family 9C member 7 2 2
MIRT713733 SUCO SUN domain containing ossification factor 2 2
MIRT715006 TSPAN11 tetraspanin 11 2 2
MIRT718400 ALDH1A3 aldehyde dehydrogenase 1 family member A3 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4476 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4476 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-4476 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-miR-4476 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4476 Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-mir-4476 Androstenedione 6128 NSC9563 resistant cell line (MCF-7)
hsa-mir-4476 Androstenedione+Anastrozole resistant cell line (MCF-7)
hsa-mir-4476 Androstenedione+Letrozole resistant cell line (MCF-7)
hsa-miR-4476 Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-4476 Paclitaxel 36314 NSC125973 approved sensitive cell line (HS578T)
hsa-miR-4476 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-4476 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4476 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4476 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4476 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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