miRTarBase - #MIRT264966


—
pre-miRNA Information
pre-miRNA hsa-mir-4251   
Genomic Coordinates chr1: 3127975 - 3128035
Description Homo sapiens miR-4251 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4251
Sequence 35| CCUGAGAAAAGGGCCAA |51
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs529666453 6 dbSNP
rs761641851 13 dbSNP
rs1417009298 15 dbSNP
rs915117785 17 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TMEM136   
Synonyms -
Description transmembrane protein 136
Transcript NM_174926   
Expression
Putative miRNA Targets on TMEM136
3'UTR of TMEM136
(miRNA target sites are highlighted)		 
>TMEM136|NM_174926|3'UTR
   1 CCAAGGCTTGCTCCAGATTATGGATTGGGTTAAGTCAGCCATGGGAACCAGGTTGGAAATATGACTGTTACATAATTACA
  81 CTTATAACAAACTTAGGTTTCAATAAAGGGCTAAATGTATTGATCAATTTGGTCAGTCTTCAAGCCGAGCATATACCAGT
 161 ATTAAAACACTAACTTCTACAGTAGCACAGTTGTAGAAAGTGAGAATACTCCATGGTAGTTGGGAATAAGTGAGAACTGT
 241 GAAGTGAGTACAACTGGCATTTGTTTTCATTTGTGGTGACCCTGGGTCCTCCTGTCCCTGGGAGGTTTGATGTTCAGGCA
 321 GTTTAGAAAGGAACTCGAAAAAGATTAGTGCTATTTCTTGTTCCTTTGAGAAGTAACTCTTTCAATAAACACTTATTTCT
 401 GCTTTCCATATAGCAATTTATCTAAGTTTACCCCATTTACTATAAAGTGAGGGGCTTACAGGAAGAGACACGCCTTTGAC
 481 ATTCTGAACATTAGATCGGGGAATTGGGTCGCTTAAACAGAGGGGCATAGGAGGGTGAGAGTGAAACTGGCAGTGAGGGG
 561 GAGGGCTACTTACTGAACCTCCTATACCAACTGTGCCAGAGGTGCCCAAGACCACTGCCAGGTTCTGTAATTCTCTGGGA
 641 AGACTCAGTGGACTCAGCATATAGTCTTACTTATAGTTTTGATTTATTATAGTGAAAAGATACAAAGAAAAATCGGTAAA
 721 AGGAAAAGGCACCTGAGACAAAGTCTAGGGTAAAGCAAGCACAAGTTTCCAGAGTCCTCTCCCAATGGAATCACACAGGA
 801 TGCACTTAATTCCCCTAGCAGTGATTTGTTACGACATGTGAATGAGTTGTCTACTGGACAAGGTCACTACAGACTCAGTG
 881 CCCAAAGTTTTTACTGAGGACAGGTCATCTAGGCAGGCTTTCCCTGGCAGATAGCAAAATTCAAGACTCTCAAAAGGAAA
 961 GCAGGTGTTCAGCATAAGCCATATTGTTTGCACAAGCAGTTCAGACACAGTAAGCCAGTCTTATCAGTTAATTGTGGGAG
1041 CCCCTCCAAAATCTAAGTTCCCAAATGCCGGCCAGTGGCCAACCCTGTAATCAGGCCTCTCCAAGGATAGCAGTTTAGGC
1121 CTGCTATGTTAACTCTTTTCTGCACAAAACCTATAGAGTTAGGGCTTTGGATCTGAGATGAATGAAGTGTGGGTAGATTT
1201 ACTGAGTCCTGTTATATGGGTTCTGCCCTACCAGGAAAACTATGCCAGTTCTCAGGGCTTTTGTGCATTAATCTCCTAGG
1281 CATTTGAGGCTATGACTAAATTCCATAGGGATTTATCATGTGGATTCCACTGTGCTTGAGATGGCAGTTTAGATTTCAGC
1361 TCTGCTGTACATATTGCAAACTAGAGCCAAAGACTTTAAAGTGTGTACTGGCCTCAGGGGGATGAGGTTAATTTTTTTTT
1441 TTCATTTTAGATACTTTCCCTTTTAGTACTCCTCCTACTTTTCTTATTTTTACTAAAAAGGTACCACTCTATGAACAAAC
1521 TAATAAAACAAGGCCAGTCTTGGAAGGAAAAAAATAATAATTCTTAGTGTGACAGTCTCCAAGAGAAGCAAGAATATAAG
1601 CTTAGAACAAGGGGTTAAGAATCCAGAATTCCTGGGTTCTTTTAACTAATTTTGCTACTCACTTGCCACTTTGGAGAGCT
1681 ACTCACTCACTTTGGATAGGTTACTTGTTTCTTCTTTGCCTGAGTTTAAACCTATTGTGAATGAATGAAATACCCTGTAG
1761 TATATTTCATAAATACATTATGTGGCATTTTATTAATGGAGGTCTTTAATGTAGGGCTTTTATGGAAATATGAAGTATTT
1841 ATGTATTTATTGATTATTTATTTTTACCATGTTATTGAAGTCAATGGTGTTTGATTAGCTCAGTGGGTGAGCAAGCATAT
1921 GGTGCTACTGGAGTCAAGGCTGGTCAGTAGGAAGCATCAGTCCATTCCATGGCCACTGGTAATCTAACGTAATGAATGGT
2001 GTCTTTTGTTGTTGTTGTTGTTGTTGTTGTTGTTTGAGACAGAGTCTTGCTCTGTCGCCCAGGCTGGAGTGCAGTGGTGT
2081 GATCTCAACTCACTGCAACCTCCGCCTTCTGTGTTCAAGTGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAG
2161 GCGTGTGCCACCATGCCTGGCTACTTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTGGCCAGGCTGGTCTTGAA
2241 CTCCTGACTTCATGACCCACCCGCCTCGGCCTCCCAAAGTGCTGGGATTACAGGTGTGAGCCACCGTGCCCAGCCATGAG
2321 CGGTCTTGAAAATGAAAAATGGTCTTGGCCACAGAAACCAGGTATGAGGGAGTGGTTGGAATGGTATAAAGTCATCACTG
2401 TTAGGGAAACAGTAACTTTAAATGCATGTTAACAGTGGGTCTTTAAAAATGAATGTCATTTGGTTAAAGAGTTTTGCTGG
2481 GCATTGAGATAATCTGACAGCATCTCCACTTCCTGTTTTTTTTCTTAATCTCCACTTTTTTTTTTTCTATGATGAGCGCC
2561 CCTAAAATGCTGGTAAGCTTCTTTCCAACAAAATTGCGGTCAAAGTAGGATGCTGGGGAATGCTGATTTTAGCAAAAGCT
2641 TGTAGAAAAGAGTGGCCTGGCACATGAGCTTAAAAAAAAGAAAAAAAGCTGGCTCTTGAATTTTGGCACAGTGCAACCTG
2721 TTCCATACCAGACAAATGAACAGGCTTAATCTGGTACCAATTCTTTTTCTCTCTTACTCCTCAGAAGTGAAGGGACTGCA
2801 GATCTTGTTGTTTTGGGGACACTTTCATGGAACTGTATGTAGGTTTTTTTGAATGGTGAGAAATCTGAATAATTGGTAAG
2881 GGGAAGGGAATCCCTCATTTCAGCTTTTCTTGATGTTGTTACTAATAACTATGAAAAAACTTCTGAGAGAACAATGTGAA
2961 CTGAAGATGACTCAGCAGTTAAGACAATGCTAAGTTCTGAAACCACAGGTAAATGAAGGGCTAATTAATGTGTGGTATAC
3041 TTGGACAAAATGAAGTACTCATTTGCACTGGATTACTGTGTAATGATAACGAACACTGTTCAAGAACGATTTATATTTCC
3121 ATAAGATTTGTACTAAATTTTATAAAAGTAAAACAACTTTTTAT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' aaccgGGAAAAGAGUCc 5'
               ||  ||||||| 
Target 5' ctatgCCAGTTCTCAGg 3'
 1240 - 1256 144.00 -16.90
2 
miRNA  3' aaCCGGGAA-AAGAGUcc 5'
            ||| :|| ||:|||  
Target 5' ctGGCATTTGTTTTCAtt 3'
 254 - 271 119.00 -7.20
3 
miRNA  3' aaccggGAAAAGAGUcc 5'
                |||||||:|  
Target 5' ctcctaCTTTTCTTAtt 3'
 1472 - 1488 119.00 -7.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31508107 14 COSMIC
COSN29468337 24 COSMIC
COSN30131755 97 COSMIC
COSN6988646 258 COSMIC
COSN6988647 273 COSMIC
COSN23447299 281 COSMIC
COSN8734605 809 COSMIC
COSN21414676 883 COSMIC
COSN16912542 1188 COSMIC
COSN8734606 1268 COSMIC
COSN17183038 1876 COSMIC
COSN15391017 2078 COSMIC
COSN32061978 2547 COSMIC
COSN6988648 2576 COSMIC
COSN21149014 2795 COSMIC
COSN26295808 2919 COSMIC
COSN26295062 2920 COSMIC
COSN18880057 3091 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1255632314 1 dbSNP
rs752770339 2 dbSNP
rs757244619 4 dbSNP
rs1218604382 11 dbSNP
rs765127508 14 dbSNP
rs1006619668 16 dbSNP
rs1280587982 17 dbSNP
rs750249585 21 dbSNP
rs1229334905 22 dbSNP
rs758077791 35 dbSNP
rs1377764605 44 dbSNP
rs779768248 46 dbSNP
rs181032990 49 dbSNP
rs1019798117 72 dbSNP
rs1359568865 73 dbSNP
rs923511638 78 dbSNP
rs965131934 91 dbSNP
rs933492841 93 dbSNP
rs1194213175 98 dbSNP
rs778227581 98 dbSNP
rs1242339544 111 dbSNP
rs1482169849 118 dbSNP
rs558654462 123 dbSNP
rs1255494708 139 dbSNP
rs1019940119 147 dbSNP
rs968570134 148 dbSNP
rs979087916 152 dbSNP
rs1198425687 154 dbSNP
rs1316376530 155 dbSNP
rs1183327149 156 dbSNP
rs1256789944 161 dbSNP
rs1260583882 169 dbSNP
rs1219737952 174 dbSNP
rs927123739 178 dbSNP
rs1320646736 179 dbSNP
rs141145017 181 dbSNP
rs992703189 188 dbSNP
rs1043438576 193 dbSNP
rs1330196477 200 dbSNP
rs113766450 210 dbSNP
rs1170140627 211 dbSNP
rs558316447 214 dbSNP
rs917319984 225 dbSNP
rs1171326341 229 dbSNP
rs1457324370 232 dbSNP
rs1368007280 234 dbSNP
rs940794463 254 dbSNP
rs1162764519 264 dbSNP
rs576991008 267 dbSNP
rs1425575096 270 dbSNP
rs1036356514 276 dbSNP
rs903556861 278 dbSNP
rs771191887 281 dbSNP
rs183610288 284 dbSNP
rs930872471 286 dbSNP
rs375537799 288 dbSNP
rs111737693 297 dbSNP
rs746584671 306 dbSNP
rs1246364506 310 dbSNP
rs1321721129 312 dbSNP
rs1308114082 320 dbSNP
rs1237439987 323 dbSNP
rs1380612854 327 dbSNP
rs1399917377 330 dbSNP
rs1275808508 334 dbSNP
rs575038541 336 dbSNP
rs1019097242 337 dbSNP
rs116876516 338 dbSNP
rs1459539711 345 dbSNP
rs1009947224 347 dbSNP
rs781748403 350 dbSNP
rs1006348436 351 dbSNP
rs77465188 352 dbSNP
rs968371418 353 dbSNP
rs965078872 369 dbSNP
rs974731691 376 dbSNP
rs1265885970 383 dbSNP
rs1212108868 384 dbSNP
rs115474557 396 dbSNP
rs1034666806 397 dbSNP
rs1191382469 411 dbSNP
rs958672738 415 dbSNP
rs1355400359 417 dbSNP
rs1309783367 418 dbSNP
rs1232268329 421 dbSNP
rs748594058 430 dbSNP
rs1265198049 435 dbSNP
rs993066855 436 dbSNP
rs1387257459 442 dbSNP
rs1366320151 448 dbSNP
rs917121537 462 dbSNP
rs1478857760 467 dbSNP
rs940722394 472 dbSNP
rs546155127 473 dbSNP
rs1159294939 480 dbSNP
rs1230603784 490 dbSNP
rs564355439 494 dbSNP
rs761376994 499 dbSNP
rs920571874 503 dbSNP
rs1261922747 509 dbSNP
rs1412977065 511 dbSNP
rs925023715 512 dbSNP
rs1488947848 519 dbSNP
rs930653476 519 dbSNP
rs1360085848 531 dbSNP
rs1050480531 540 dbSNP
rs1054777240 547 dbSNP
rs1342671264 554 dbSNP
rs1257513213 556 dbSNP
rs896418183 565 dbSNP
rs889349815 571 dbSNP
rs1013539377 574 dbSNP
rs531610304 580 dbSNP
rs1342403660 583 dbSNP
rs1319248386 585 dbSNP
rs1047674436 586 dbSNP
rs886305592 593 dbSNP
rs144881113 596 dbSNP
rs568221079 634 dbSNP
rs1400089774 645 dbSNP
rs1423555686 648 dbSNP
rs1016762097 649 dbSNP
rs769902373 655 dbSNP
rs964801519 657 dbSNP
rs1242171141 658 dbSNP
rs1186450728 670 dbSNP
rs111355480 675 dbSNP
rs1030359847 688 dbSNP
rs1204079046 700 dbSNP
rs1317003957 701 dbSNP
rs1256111033 702 dbSNP
rs1220579033 704 dbSNP
rs1220334064 714 dbSNP
rs548128682 715 dbSNP
rs574739609 716 dbSNP
rs1447659935 719 dbSNP
rs1338913283 720 dbSNP
rs76240371 733 dbSNP
rs554271835 771 dbSNP
rs1034057975 778 dbSNP
rs1169226101 784 dbSNP
rs1467616553 785 dbSNP
rs978916450 786 dbSNP
rs958864412 806 dbSNP
rs181046472 811 dbSNP
rs1369845936 820 dbSNP
rs570428485 826 dbSNP
rs1457169933 833 dbSNP
rs1024106069 834 dbSNP
rs961890898 844 dbSNP
rs751824020 854 dbSNP
rs1273874161 860 dbSNP
rs11217821 876 dbSNP
rs1354253364 881 dbSNP
rs1439491499 884 dbSNP
rs1246962301 886 dbSNP
rs920666694 887 dbSNP
rs1329724982 892 dbSNP
rs917627395 910 dbSNP
rs556253065 919 dbSNP
rs560730359 922 dbSNP
rs1323403179 944 dbSNP
rs1363008607 947 dbSNP
rs149551518 951 dbSNP
rs1163880561 980 dbSNP
rs1438656643 987 dbSNP
rs1322364916 997 dbSNP
rs1378323194 1003 dbSNP
rs1180261479 1008 dbSNP
rs886315413 1009 dbSNP
rs1246058063 1015 dbSNP
rs1219230950 1017 dbSNP
rs1449990971 1017 dbSNP
rs1294003081 1045 dbSNP
rs910590567 1053 dbSNP
rs1437942881 1060 dbSNP
rs554097558 1069 dbSNP
rs944911519 1070 dbSNP
rs77638110 1071 dbSNP
rs752821461 1083 dbSNP
rs866202214 1099 dbSNP
rs945533384 1100 dbSNP
rs1237695408 1105 dbSNP
rs900319091 1119 dbSNP
rs1374463388 1122 dbSNP
rs114924819 1124 dbSNP
rs1354394326 1127 dbSNP
rs1266820470 1131 dbSNP
rs1030371660 1136 dbSNP
rs764648311 1145 dbSNP
rs1289294158 1150 dbSNP
rs1358246348 1152 dbSNP
rs371114072 1154 dbSNP
rs1160010062 1155 dbSNP
rs754272022 1158 dbSNP
rs1449969976 1159 dbSNP
rs1401105359 1163 dbSNP
rs890492120 1176 dbSNP
rs1189446191 1179 dbSNP
rs757653326 1180 dbSNP
rs779096930 1181 dbSNP
rs1010158913 1194 dbSNP
rs1200252168 1199 dbSNP
rs1487968146 1205 dbSNP
rs776984255 1209 dbSNP
rs117408684 1216 dbSNP
rs894144145 1217 dbSNP
rs531553911 1220 dbSNP
rs780972080 1231 dbSNP
rs1278319223 1257 dbSNP
rs1177228794 1258 dbSNP
rs1024242022 1267 dbSNP
rs1034553820 1287 dbSNP
rs543423725 1316 dbSNP
rs1284421409 1331 dbSNP
rs1398853380 1332 dbSNP
rs1337717011 1333 dbSNP
rs1290287666 1335 dbSNP
rs1163225966 1339 dbSNP
rs990617585 1343 dbSNP
rs1358431144 1346 dbSNP
rs917637404 1348 dbSNP
rs949033724 1354 dbSNP
rs1429917187 1363 dbSNP
rs1169826541 1367 dbSNP
rs1323568143 1370 dbSNP
rs747719445 1395 dbSNP
rs1399182001 1401 dbSNP
rs983090114 1403 dbSNP
rs1188544421 1404 dbSNP
rs1486311849 1412 dbSNP
rs907806576 1416 dbSNP
rs993314435 1418 dbSNP
rs1027530990 1424 dbSNP
rs1038002886 1425 dbSNP
rs1264337823 1426 dbSNP
rs1333175502 1427 dbSNP
rs1382493370 1432 dbSNP
rs796462272 1432 dbSNP
rs931800377 1432 dbSNP
rs1300649777 1438 dbSNP
rs1051807217 1443 dbSNP
rs1377320493 1444 dbSNP
rs1446966877 1445 dbSNP
rs539858092 1456 dbSNP
rs1010211383 1458 dbSNP
rs1358304709 1467 dbSNP
rs1020216095 1468 dbSNP
rs1429134470 1469 dbSNP
rs774042754 1478 dbSNP
rs1413351902 1487 dbSNP
rs904511222 1488 dbSNP
rs35393415 1495 dbSNP
rs561839936 1502 dbSNP
rs910517896 1508 dbSNP
rs1198644782 1510 dbSNP
rs529396582 1512 dbSNP
rs1196953964 1515 dbSNP
rs966028623 1517 dbSNP
rs976081501 1527 dbSNP
rs1320553952 1538 dbSNP
rs1378373485 1547 dbSNP
rs773287637 1556 dbSNP
rs749126633 1557 dbSNP
rs1247693547 1560 dbSNP
rs1383303883 1567 dbSNP
rs1043864698 1573 dbSNP
rs1187211150 1574 dbSNP
rs770785900 1581 dbSNP
rs564683343 1584 dbSNP
rs1024745640 1586 dbSNP
rs566585781 1605 dbSNP
rs1462587928 1609 dbSNP
rs1055567000 1613 dbSNP
rs1349324324 1614 dbSNP
rs1178285520 1629 dbSNP
rs894105131 1636 dbSNP
rs532437788 1638 dbSNP
rs1178426562 1640 dbSNP
rs1417635854 1657 dbSNP
rs144286300 1658 dbSNP
rs983185124 1667 dbSNP
rs907562807 1668 dbSNP
rs1263136113 1670 dbSNP
rs552161008 1673 dbSNP
rs1359686791 1681 dbSNP
rs1308001780 1682 dbSNP
rs1237689837 1687 dbSNP
rs993450337 1689 dbSNP
rs544225556 1692 dbSNP
rs1386421205 1699 dbSNP
rs1386122052 1701 dbSNP
rs759346712 1751 dbSNP
rs570767604 1753 dbSNP
rs1301359107 1764 dbSNP
rs1426565575 1774 dbSNP
rs1395250024 1777 dbSNP
rs1331873134 1793 dbSNP
rs921811263 1800 dbSNP
rs931837230 1812 dbSNP
rs887634187 1816 dbSNP
rs1008026569 1831 dbSNP
rs1294030041 1832 dbSNP
rs1017673230 1839 dbSNP
rs1183220579 1842 dbSNP
rs966122061 1843 dbSNP
rs766956141 1851 dbSNP
rs1339984717 1854 dbSNP
rs537830802 1857 dbSNP
rs911992314 1858 dbSNP
rs1490350633 1862 dbSNP
rs1260256020 1872 dbSNP
rs1020944346 1878 dbSNP
rs1284904793 1880 dbSNP
rs946167365 1883 dbSNP
rs767782464 1885 dbSNP
rs1340238684 1886 dbSNP
rs556240816 1902 dbSNP
rs1310381692 1903 dbSNP
rs1285044053 1917 dbSNP
rs1200309268 1920 dbSNP
rs568139543 1923 dbSNP
rs760743751 1928 dbSNP
rs752618840 1929 dbSNP
rs1297876660 1938 dbSNP
rs148316986 1940 dbSNP
rs553845567 1944 dbSNP
rs938211501 1948 dbSNP
rs1159493207 1955 dbSNP
rs12287245 1961 dbSNP
rs1444685317 1971 dbSNP
rs1056051973 1974 dbSNP
rs1263048979 1975 dbSNP
rs991418457 1976 dbSNP
rs1179157066 1980 dbSNP
rs572517637 1989 dbSNP
rs1195138810 1990 dbSNP
rs1190630226 1995 dbSNP
rs1448364955 1996 dbSNP
rs949814137 1997 dbSNP
rs894693895 2000 dbSNP
rs552598194 2003 dbSNP
rs1014442382 2006 dbSNP
rs1024506995 2006 dbSNP
rs1277644744 2006 dbSNP
rs531300237 2006 dbSNP
rs764893851 2006 dbSNP
rs773499720 2006 dbSNP
rs1045420516 2009 dbSNP
rs754390833 2012 dbSNP
rs1465227883 2015 dbSNP
rs1319148008 2019 dbSNP
rs951507496 2033 dbSNP
rs58377417 2035 dbSNP
rs78505084 2035 dbSNP
rs1470571669 2036 dbSNP
rs1404050428 2050 dbSNP
rs185919466 2055 dbSNP
rs576371970 2057 dbSNP
rs1048992833 2058 dbSNP
rs1244716264 2061 dbSNP
rs1204305174 2068 dbSNP
rs758824823 2070 dbSNP
rs1457256134 2074 dbSNP
rs543411575 2078 dbSNP
rs1194152552 2080 dbSNP
rs1341509288 2090 dbSNP
rs1271012408 2092 dbSNP
rs1245489010 2094 dbSNP
rs1398236181 2096 dbSNP
rs561777927 2104 dbSNP
rs1454037317 2105 dbSNP
rs1400219814 2121 dbSNP
rs921890566 2126 dbSNP
rs1411176921 2129 dbSNP
rs147519184 2131 dbSNP
rs1017889935 2139 dbSNP
rs901933504 2141 dbSNP
rs1273482095 2143 dbSNP
rs541132205 2144 dbSNP
rs1183980126 2145 dbSNP
rs372589124 2146 dbSNP
rs1347615964 2153 dbSNP
rs1438775903 2154 dbSNP
rs1211982906 2164 dbSNP
rs1206476178 2172 dbSNP
rs1439683053 2175 dbSNP
rs1285944142 2176 dbSNP
rs1020878569 2178 dbSNP
rs1487554010 2180 dbSNP
rs559820016 2181 dbSNP
rs966694853 2191 dbSNP
rs1372995159 2193 dbSNP
rs562793502 2206 dbSNP
rs1444956296 2207 dbSNP
rs980069038 2209 dbSNP
rs1032575919 2219 dbSNP
rs112946342 2229 dbSNP
rs990994020 2230 dbSNP
rs936033299 2232 dbSNP
rs527449192 2242 dbSNP
rs1012907213 2260 dbSNP
rs1454564010 2263 dbSNP
rs918127011 2264 dbSNP
rs1418887810 2268 dbSNP
rs191462626 2269 dbSNP
rs1178917804 2271 dbSNP
rs894462914 2272 dbSNP
rs1233581344 2273 dbSNP
rs1198807086 2277 dbSNP
rs1489868745 2285 dbSNP
rs777374008 2286 dbSNP
rs1223477001 2292 dbSNP
rs1046011549 2306 dbSNP
rs1282595566 2311 dbSNP
rs1226038297 2316 dbSNP
rs1300171737 2320 dbSNP
rs1385723749 2322 dbSNP
rs368088242 2323 dbSNP
rs1402590134 2324 dbSNP
rs1346791160 2326 dbSNP
rs34298380 2336 dbSNP
rs1004350350 2337 dbSNP
rs1014679454 2342 dbSNP
rs1161001277 2343 dbSNP
rs566995459 2352 dbSNP
rs1424411184 2353 dbSNP
rs1174120026 2369 dbSNP
rs1479526536 2376 dbSNP
rs1431504751 2377 dbSNP
rs1200505019 2385 dbSNP
rs12806740 2405 dbSNP
rs1352221421 2406 dbSNP
rs1049234813 2413 dbSNP
rs1242919121 2413 dbSNP
rs909125249 2427 dbSNP
rs12364701 2429 dbSNP
rs556900405 2439 dbSNP
rs1207497877 2446 dbSNP
rs79259333 2450 dbSNP
rs1325119595 2462 dbSNP
rs1018811769 2467 dbSNP
rs1213685792 2480 dbSNP
rs1038827957 2498 dbSNP
rs977632561 2499 dbSNP
rs1431232366 2505 dbSNP
rs901692852 2513 dbSNP
rs202245791 2516 dbSNP
rs1334659365 2517 dbSNP
rs1427930405 2536 dbSNP
rs61608130 2536 dbSNP
rs71729773 2536 dbSNP
rs796621851 2536 dbSNP
rs936111060 2536 dbSNP
rs181779133 2547 dbSNP
rs1378227498 2548 dbSNP
rs1441514187 2550 dbSNP
rs1159782509 2552 dbSNP
rs1367770723 2553 dbSNP
rs1457481040 2556 dbSNP
rs535453196 2558 dbSNP
rs140059458 2559 dbSNP
rs1203214306 2570 dbSNP
rs1046022278 2576 dbSNP
rs887318262 2581 dbSNP
rs1375104145 2586 dbSNP
rs565778191 2588 dbSNP
rs902628395 2592 dbSNP
rs145710378 2598 dbSNP
rs995020666 2599 dbSNP
rs1297503097 2600 dbSNP
rs1032790383 2603 dbSNP
rs1352813078 2604 dbSNP
rs557978839 2606 dbSNP
rs1172863239 2607 dbSNP
rs1321576623 2608 dbSNP
rs959645716 2609 dbSNP
rs1385069110 2610 dbSNP
rs1012914537 2611 dbSNP
rs1025111171 2613 dbSNP
rs1182148549 2615 dbSNP
rs970906257 2641 dbSNP
rs576309018 2642 dbSNP
rs1244330075 2651 dbSNP
rs1177113692 2657 dbSNP
rs918997883 2659 dbSNP
rs1252546512 2672 dbSNP
rs888817364 2672 dbSNP
rs950558088 2679 dbSNP
rs1058187 2681 dbSNP
rs1204848013 2690 dbSNP
rs1358299549 2719 dbSNP
rs528301984 2724 dbSNP
rs1242070579 2726 dbSNP
rs1008476274 2727 dbSNP
rs1383187601 2729 dbSNP
rs1266685770 2730 dbSNP
rs1018833109 2734 dbSNP
rs1389577609 2737 dbSNP
rs1335132137 2742 dbSNP
rs1197588567 2753 dbSNP
rs967237899 2763 dbSNP
rs984472715 2768 dbSNP
rs1365195353 2776 dbSNP
rs908873490 2780 dbSNP
rs1369379433 2781 dbSNP
rs943266599 2795 dbSNP
rs537382969 2802 dbSNP
rs1038941365 2803 dbSNP
rs923084131 2804 dbSNP
rs1177509674 2805 dbSNP
rs933136021 2806 dbSNP
rs555657580 2807 dbSNP
rs1490031273 2808 dbSNP
rs1042230848 2823 dbSNP
rs1266353855 2831 dbSNP
rs957223732 2834 dbSNP
rs1359942830 2836 dbSNP
rs1255389157 2841 dbSNP
rs902597515 2869 dbSNP
rs915963098 2873 dbSNP
rs1307542032 2882 dbSNP
rs147315269 2903 dbSNP
rs1344909318 2904 dbSNP
rs1053751969 2906 dbSNP
rs541419510 2923 dbSNP
rs1406989035 2926 dbSNP
rs187391022 2927 dbSNP
rs1288668713 2928 dbSNP
rs908808711 2929 dbSNP
rs1398310896 2930 dbSNP
rs1366086546 2948 dbSNP
rs371274931 2949 dbSNP
rs775698768 2956 dbSNP
rs192288143 2968 dbSNP
rs1426554857 2973 dbSNP
rs1463860266 2974 dbSNP
rs760837506 2977 dbSNP
rs764190183 2992 dbSNP
rs182599225 3016 dbSNP
rs1203168254 3020 dbSNP
rs114037365 3021 dbSNP
rs950459154 3031 dbSNP
rs984956551 3032 dbSNP
rs932830726 3038 dbSNP
rs531547510 3040 dbSNP
rs964751201 3044 dbSNP
rs888840000 3046 dbSNP
rs1281438292 3056 dbSNP
rs974404347 3058 dbSNP
rs1355579559 3072 dbSNP
rs1225363859 3075 dbSNP
rs1331903375 3085 dbSNP
rs546451757 3086 dbSNP
rs539169285 3091 dbSNP
rs1008528552 3094 dbSNP
rs1319480345 3096 dbSNP
rs933271955 3097 dbSNP
rs977890979 3108 dbSNP
rs562017454 3109 dbSNP
rs1469737857 3122 dbSNP
rs923771614 3123 dbSNP
rs1177987822 3126 dbSNP
rs1183492401 3133 dbSNP
rs557831490 3134 dbSNP
rs1190517110 3135 dbSNP
rs1475586016 3137 dbSNP
rs1248405031 3138 dbSNP
rs758456866 3143 dbSNP
rs999216285 3161 dbSNP
rs1032920118 3164 dbSNP
rs528841346 3165 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 219902.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065668. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' aaccgggaaAAGAGUCc 5'
                   ||||||| 
Target 5' ---------UUCUCAGg 3'
 		1 - 8
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM1065668
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_7
Location of target site ENST00000529187.1 | 3UTR | UUCUCAGGGCUUUUGUGCAUUAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
98 hsa-miR-4251 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056156 OTUD1 OTU deubiquitinase 1 2 2
MIRT080004 MYL12B myosin light chain 12B 2 2
MIRT080407 ONECUT2 one cut homeobox 2 2 2
MIRT081901 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT090342 SEC61A1 Sec61 translocon alpha 1 subunit 2 8
MIRT096824 ZSWIM6 zinc finger SWIM-type containing 6 2 4
MIRT140185 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT149716 LDLR low density lipoprotein receptor 2 6
MIRT205293 STK11IP serine/threonine kinase 11 interacting protein 2 2
MIRT213265 REST RE1 silencing transcription factor 2 6
MIRT254069 BACH1 BTB domain and CNC homolog 1 2 2
MIRT256251 ANKRD33B ankyrin repeat domain 33B 2 2
MIRT264966 TMEM136 transmembrane protein 136 2 2
MIRT267496 FEN1 flap structure-specific endonuclease 1 2 2
MIRT285077 MIER1 MIER1 transcriptional regulator 2 2
MIRT296167 NCOA3 nuclear receptor coactivator 3 2 2
MIRT316073 ABRACL ABRA C-terminal like 2 2
MIRT360286 HIST1H3E histone cluster 1 H3 family member e 2 2
MIRT364793 PRRC2B proline rich coiled-coil 2B 2 2
MIRT443277 TSPAN15 tetraspanin 15 2 2
MIRT443453 CLIC5 chloride intracellular channel 5 2 2
MIRT445938 KLHL32 kelch like family member 32 2 2
MIRT448012 HLA-DOA major histocompatibility complex, class II, DO alpha 2 2
MIRT448382 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 4
MIRT448499 RYBP RING1 and YY1 binding protein 2 2
MIRT449896 C11orf34 placenta expressed transcript 1 1 2
MIRT450457 ZDHHC2 zinc finger DHHC-type containing 2 2 2
MIRT450849 HTR2A 5-hydroxytryptamine receptor 2A 2 2
MIRT453774 NUCB1 nucleobindin 1 2 10
MIRT464399 URM1 ubiquitin related modifier 1 2 2
MIRT465008 TUBB2A tubulin beta 2A class IIa 2 8
MIRT465145 TSC22D2 TSC22 domain family member 2 2 2
MIRT467799 SLC2A14 solute carrier family 2 member 14 2 2
MIRT472597 NACC1 nucleus accumbens associated 1 2 2
MIRT477969 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT486586 ZNF619 zinc finger protein 619 2 2
MIRT487739 MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 2 4
MIRT492529 PTMA prothymosin, alpha 2 6
MIRT496845 KCNIP2 potassium voltage-gated channel interacting protein 2 2 2
MIRT499064 CTBP1 C-terminal binding protein 1 2 4
MIRT502046 LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 2 6
MIRT503907 ZSCAN25 zinc finger and SCAN domain containing 25 2 2
MIRT506776 KLHL15 kelch like family member 15 2 4
MIRT510003 UCP1 uncoupling protein 1 2 6
MIRT513040 BRIX1 BRX1, biogenesis of ribosomes 2 2
MIRT513174 MOAP1 modulator of apoptosis 1 2 6
MIRT517592 ZNF579 zinc finger protein 579 2 4
MIRT521825 POLR1D RNA polymerase I subunit D 2 2
MIRT530663 TRIM56 tripartite motif containing 56 2 2
MIRT531718 TARS threonyl-tRNA synthetase 2 2
MIRT535154 PLEKHG5 pleckstrin homology and RhoGEF domain containing G5 2 2
MIRT536385 LEFTY1 left-right determination factor 1 2 2
MIRT543847 APIP APAF1 interacting protein 2 2
MIRT546973 PRKAB2 protein kinase AMP-activated non-catalytic subunit beta 2 2 2
MIRT548667 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT548799 CLIP4 CAP-Gly domain containing linker protein family member 4 2 4
MIRT549610 TMEM101 transmembrane protein 101 2 2
MIRT549716 NUP37 nucleoporin 37 2 4
MIRT549873 ZNF260 zinc finger protein 260 2 2
MIRT555383 PPP1CC protein phosphatase 1 catalytic subunit gamma 2 2
MIRT566976 LBR lamin B receptor 2 2
MIRT568052 CHSY1 chondroitin sulfate synthase 1 2 2
MIRT570970 TMBIM4 transmembrane BAX inhibitor motif containing 4 2 2
MIRT571174 ZNF85 zinc finger protein 85 2 2
MIRT571364 ZNF45 zinc finger protein 45 2 2
MIRT572309 LSM4 LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated 2 2
MIRT572493 BTN2A2 butyrophilin subfamily 2 member A2 2 2
MIRT606783 KIAA0040 KIAA0040 2 5
MIRT607952 NFAM1 NFAT activating protein with ITAM motif 1 2 10
MIRT609978 HERPUD2 HERPUD family member 2 2 2
MIRT610069 CD300E CD300e molecule 2 2
MIRT610118 IL17REL interleukin 17 receptor E like 2 2
MIRT610151 PRMT8 protein arginine methyltransferase 8 2 4
MIRT611075 ZNF621 zinc finger protein 621 2 2
MIRT612011 COX17 COX17, cytochrome c oxidase copper chaperone 2 2
MIRT617901 PTCHD3 patched domain containing 3 2 2
MIRT618052 MRVI1 murine retrovirus integration site 1 homolog 2 2
MIRT619526 ZNF74 zinc finger protein 74 2 2
MIRT624276 CRISPLD2 cysteine rich secretory protein LCCL domain containing 2 2 2
MIRT625357 MGLL monoglyceride lipase 2 2
MIRT626756 NDUFA9 NADH:ubiquinone oxidoreductase subunit A9 2 2
MIRT628851 FAM151B family with sequence similarity 151 member B 2 2
MIRT630458 GMPS guanine monophosphate synthase 2 2
MIRT634536 MRPS17 mitochondrial ribosomal protein S17 2 2
MIRT638806 DCTN3 dynactin subunit 3 2 2
MIRT647607 TMTC2 transmembrane and tetratricopeptide repeat containing 2 2 2
MIRT650885 PPP1R15A protein phosphatase 1 regulatory subunit 15A 2 2
MIRT653507 SLC43A2 solute carrier family 43 member 2 2 2
MIRT658608 ENTPD5 ectonucleoside triphosphate diphosphohydrolase 5 2 2
MIRT666345 SKAP2 src kinase associated phosphoprotein 2 2 2
MIRT693743 ACACA acetyl-CoA carboxylase alpha 2 2
MIRT704049 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT709789 CYBRD1 cytochrome b reductase 1 2 2
MIRT711837 AMOTL2 angiomotin like 2 2 2
MIRT711875 VASP vasodilator stimulated phosphoprotein 2 2
MIRT717349 RAB40A RAB40A, member RAS oncogene family 2 2
MIRT717746 MYLK myosin light chain kinase 2 2
MIRT725398 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4251 Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-4251 Doxorubicin 31703 NSC123127 approved resistant High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-mir-4251 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-4251 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4251 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)

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