miRTarBase - #MIRT266594


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pre-miRNA Information
pre-miRNA hsa-mir-6733   
Genomic Coordinates chr1: 43171652 - 43171712
Description Homo sapiens miR-6733 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6733-5p
Sequence 6| UGGGAAAGACAAACUCAGAGUU |27
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs953882106 3 dbSNP
rs371499741 9 dbSNP
rs778441909 21 dbSNP
rs1348902205 22 dbSNP
Putative Targets

Gene Information
Gene Symbol POGZ   
Synonyms MRD37, WHSUS, ZNF280E, ZNF635, ZNF635m
Description pogo transposable element derived with ZNF domain
Transcript NM_015100   
Other Transcripts NM_145796 , NM_207171   
Expression
Putative miRNA Targets on POGZ
3'UTR of POGZ
(miRNA target sites are highlighted)		 
>POGZ|NM_015100|3'UTR
   1 GTGTTGGGGTCATGAGGGGGTGTGGAGTGAGGGTGGGAACATGTGAGGGAGGGTAAAGGGGCTTAGGGAAAAGGGGGCAT
  81 ACCAGGTGGGGTATTTGGTTTCTATTTTTTAATTTTATACCACCACTCCCCCCTGAAGTTGACTTACACTTCCCTGTGGA
 161 TTTGTGGATTAATTAGGAAAACCAATAGTAATCACGTCTGAGCCAAGGAGCTGGCCCATTGGTCATTCACTTCTGCTAAA
 241 AACAGGTTTTTGTGACTTTTTTTTTTTTTAAATTTAAATCACTGTGTTTGGTATTTTTCTGACAAAATTAAGAAAAAGAA
 321 AAAAAATTATTTGTGGGCAAATGTTAAATTTTTTTGTTTCCCCTTTTACCTCAATTGTATCATAGTACTGGGTTTTTTTG
 401 TTTGTTTTATTGTGTGGCCAATGTCTTTGGGCATGATGCTATCTAATCATTGTTAATGTGAGAACATTTCTGAAGATGGG
 481 AAAGACAAATTATGTAGCTCACAAACTGGTTTATTATATATATGGATAAAAAACTTTTTTCATTGTGGTCTTAACACTTT
 561 TATATAAAAATGAAAATGGAAAAAAAGTCCCACTGAACTCTCTCTTCCTTCTCCTTTTCTTTCCTTCCCTCTCCAGAGAT
 641 GTTGGTTTCTACAGCAACCCTAGATATAAAATTGTGGCTTTAAAAATGCATGAAACCACCTTTAATTATCCAGAATGAAT
 721 AGATTTGTCTTTTCCTCACCACCTTCCCTCCAAAACATGACATAAACAATATTTTTTGCACTTGTGATCCTTGGCCCCTT
 801 TCCCCATTCTCAACACCATCCATCCCTCTGGACAAAGGATCATACAGGTGTTATTAGCAAGCAAGAGATACTGAAGCGAT
 881 CAAACAGTTTTAGGGTGGAAGCCATTCCCAGTTTGAGTCTTCATCCTGTAAGCCCCCAGGGGCAGTCCCTGCTTTACTGA
 961 ACTTCATCCTGTTAGATGGAGAGCATGCCTGTTTAAGGGATTACTGGTCCTACAGCCAGGAGCTAATTGTTCAAGAAGTG
1041 TTGAACTTTAAAAAGACAAGACCACTTGTTGAAATCCAGCGTGCTCTGTGGCTTTCCCCTATTTCTCTTAATACTTAGGG
1121 AAGAATCTGACAGGAAGAAGCGCACAGGGGTGTGCACAAAGAAAATGACATGAATCTTTATTTTTCACTGCCAGCTTCAA
1201 GGAAAGAAAATTTTTTCTACAATTTGCATGAGGGATTTTTTTAATTGTATGTACTCATGGTTGTAAACCAAAACGTACTG
1281 TACCGTACAGAGAAAAGGAGCAAAAAACCAAGTCTTCTGTTTATCCTGAGGCTTTCCACAATGTTCCCCTCCTGTGAGCC
1361 AAGGAGGCAAACTGCACAAGCTTGTAAATGGTTCGTCTTTAAAATGTACATAAGTGGAACATTTAATAAAATGAGGGGAA
1441 ATGGATTTATAAACTTGTTTTTTTTCTAGGTGACCCTGTTTAATAGGCTTTCACAGACTGGGGAATGCTCAAGATGTGAT
1521 GGGCCTGGTGGTACAGGTGTGACATTTGTTACCACCCATTTCTCCCACCCCACCCTGCTTTTTTGTTTGTTTGTTTTTTC
1601 ATCCCCCAGCACACTATAATATAGTGAACTGGAAAAGTCCCTTCCAGAAACAGCTTGGCCAGCTTTGTGAACCTTTGACA
1681 TCTGAAAACAACCAAGGATCCATCTGGGCTTCTCTTCCCCAGCTTTTTGCCTGATGCCATTTTATTGACAGACAATGGAC
1761 TTTGAAGTCAGCCTTTGCCTTTGAGAAAGTTCAAGAACTATGGTTGGTCACGTCTATCTACAACCTAATCCTACTCTTTG
1841 GTAGTCTCTGCAGCAGCCACAGCCTTAGCAGAGCTGGGGTTCCTGTCTTCTGCACACGATTGACTTTCTTGATGGGTAAT
1921 TTTTTTTAAGATTATACCAACAGTGGATCAGCTGGGTTTTGGCCAGGAAGTTGTCTTTGTGGACTCTGCCTGCATGGCTT
2001 AGTAGTAGAAGGAAATTTTTTTTTGGTTTTGTTTTTTATAATTCAGTTTAATCAATAAACATGTATTTATTGACTGTTAA
2081 AAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuGAGACUCAAACAGAAAGGGu 5'
            |||||    || ||||||| 
Target 5' tgCTCTG----TGGCTTTCCCc 3'
 1082 - 1099 158.00 -16.80
2 
miRNA  3' uugagacUC-AAACAGAAAGGGu 5'
                 || |||||||||:|| 
Target 5' aatgaatAGATTTGTCTTTTCCt 3'
 714 - 736 151.00 -14.70
3 
miRNA  3' uuGAGACUCA--AAC---AGAAAGGGu 5'
            :| ||| |  |||    ||||||| 
Target 5' acTTGTGA-TCCTTGGCCCCTTTCCCc 3'
 780 - 805 145.00 -11.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1196316 270 ClinVar
COSN25773725 28 COSMIC
COSN30519413 45 COSMIC
COSN30100359 104 COSMIC
COSN28192160 153 COSMIC
COSN30165922 162 COSMIC
COSN31514894 214 COSMIC
COSN28201329 269 COSMIC
COSN31607082 270 COSMIC
COSN31576856 327 COSMIC
COSN31487363 541 COSMIC
COSN20090358 632 COSMIC
COSN22469086 780 COSMIC
COSN21774101 781 COSMIC
COSN22765075 1081 COSMIC
COSN28686882 1173 COSMIC
COSN15586231 1192 COSMIC
COSN22645072 1193 COSMIC
COSN28645422 1203 COSMIC
COSN24096942 1207 COSMIC
COSN28650276 1211 COSMIC
COSN17075910 1395 COSMIC
COSN31568536 1452 COSMIC
COSN30172116 1457 COSMIC
COSN32082753 1632 COSMIC
COSN26554720 1723 COSMIC
COSN31523178 1770 COSMIC
COSN31526480 1792 COSMIC
COSN26564183 1824 COSMIC
COSN6002644 1836 COSMIC
COSN30177102 1911 COSMIC
COSN15661071 2053 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs762862639 3 dbSNP
rs565910039 5 dbSNP
rs1423218622 7 dbSNP
rs1262321744 9 dbSNP
rs746222426 15 dbSNP
rs774043161 16 dbSNP
rs966762792 19 dbSNP
rs1021355092 20 dbSNP
rs1293398872 21 dbSNP
rs1368948128 21 dbSNP
rs770589404 22 dbSNP
rs748855637 23 dbSNP
rs1361004196 28 dbSNP
rs899803652 29 dbSNP
rs6667714 30 dbSNP
rs1243393917 31 dbSNP
rs769125530 33 dbSNP
rs1298355033 34 dbSNP
rs1005601110 40 dbSNP
rs748097042 42 dbSNP
rs773099326 43 dbSNP
rs199586607 45 dbSNP
rs1363913937 46 dbSNP
rs1163068928 51 dbSNP
rs1220953869 58 dbSNP
rs1335076988 63 dbSNP
rs569625425 67 dbSNP
rs1489445540 69 dbSNP
rs549332677 75 dbSNP
rs888625395 77 dbSNP
rs1047256996 78 dbSNP
rs1400664581 78 dbSNP
rs1160841854 82 dbSNP
rs1172048950 83 dbSNP
rs759920419 84 dbSNP
rs536271605 96 dbSNP
rs1350947266 102 dbSNP
rs558068815 104 dbSNP
rs1306552182 105 dbSNP
rs539726466 110 dbSNP
rs1410840151 111 dbSNP
rs1290390516 117 dbSNP
rs996643505 128 dbSNP
rs900999005 132 dbSNP
rs375749581 133 dbSNP
rs896044026 135 dbSNP
rs940491890 143 dbSNP
rs878916804 147 dbSNP
rs1273835312 150 dbSNP
rs1483228043 151 dbSNP
rs1184108162 154 dbSNP
rs761830850 158 dbSNP
rs1215362450 171 dbSNP
rs1472286359 179 dbSNP
rs886802620 185 dbSNP
rs1048028244 195 dbSNP
rs191000036 196 dbSNP
rs1206859900 197 dbSNP
rs1167194201 214 dbSNP
rs926920349 225 dbSNP
rs570941251 226 dbSNP
rs1331337466 234 dbSNP
rs1272301444 241 dbSNP
rs547509977 243 dbSNP
rs890287635 252 dbSNP
rs527876824 255 dbSNP
rs772705385 257 dbSNP
rs947128354 257 dbSNP
rs913107874 258 dbSNP
rs879063879 269 dbSNP
rs1342826589 270 dbSNP
rs1384998654 270 dbSNP
rs542767502 270 dbSNP
rs923196184 270 dbSNP
rs954680615 270 dbSNP
rs974664617 280 dbSNP
rs1378082349 288 dbSNP
rs1441477270 291 dbSNP
rs552009447 293 dbSNP
rs1299548211 299 dbSNP
rs1460115864 312 dbSNP
rs1353417924 318 dbSNP
rs1447075927 320 dbSNP
rs1187420874 322 dbSNP
rs1164795478 324 dbSNP
rs1390065958 326 dbSNP
rs1005674652 327 dbSNP
rs1169994628 327 dbSNP
rs552957484 327 dbSNP
rs964393614 327 dbSNP
rs1335033703 328 dbSNP
rs1425986180 333 dbSNP
rs1383376910 337 dbSNP
rs1408604332 356 dbSNP
rs952753473 356 dbSNP
rs1432941907 363 dbSNP
rs1055464410 364 dbSNP
rs1440131276 371 dbSNP
rs1025845955 374 dbSNP
rs1343954165 376 dbSNP
rs1219603729 381 dbSNP
rs1179179163 382 dbSNP
rs1479748697 384 dbSNP
rs774421041 385 dbSNP
rs1248169268 392 dbSNP
rs1195870649 400 dbSNP
rs1465740972 400 dbSNP
rs1376445841 402 dbSNP
rs1173562808 408 dbSNP
rs543651432 408 dbSNP
rs938214079 413 dbSNP
rs1431679916 418 dbSNP
rs532006681 421 dbSNP
rs895959518 427 dbSNP
rs1389563709 435 dbSNP
rs982407073 439 dbSNP
rs1361643800 440 dbSNP
rs1384005145 441 dbSNP
rs1321449684 451 dbSNP
rs1330478964 452 dbSNP
rs1436889825 453 dbSNP
rs945594282 478 dbSNP
rs1290281879 481 dbSNP
rs1245822905 483 dbSNP
rs1326623792 491 dbSNP
rs1227472384 492 dbSNP
rs913915571 495 dbSNP
rs1352144247 502 dbSNP
rs769148921 509 dbSNP
rs989447393 521 dbSNP
rs1001758376 524 dbSNP
rs1200002872 529 dbSNP
rs905569297 532 dbSNP
rs866848487 533 dbSNP
rs1042703090 534 dbSNP
rs947164086 534 dbSNP
rs766087470 543 dbSNP
rs1389333224 548 dbSNP
rs1389896017 550 dbSNP
rs1405939196 562 dbSNP
rs958111664 564 dbSNP
rs1028450781 570 dbSNP
rs1348322616 580 dbSNP
rs1409003208 587 dbSNP
rs912972084 587 dbSNP
rs1337196358 588 dbSNP
rs1372228966 589 dbSNP
rs1264405249 595 dbSNP
rs1356248377 600 dbSNP
rs760264302 604 dbSNP
rs1052847272 606 dbSNP
rs1482247731 607 dbSNP
rs933168058 607 dbSNP
rs1406283723 609 dbSNP
rs563195406 609 dbSNP
rs1251470414 612 dbSNP
rs1421156019 612 dbSNP
rs1185489324 613 dbSNP
rs1367900675 630 dbSNP
rs923089525 631 dbSNP
rs552525751 632 dbSNP
rs1368609821 634 dbSNP
rs188171000 634 dbSNP
rs1308365156 642 dbSNP
rs1398210530 649 dbSNP
rs1393872566 653 dbSNP
rs964616045 658 dbSNP
rs1340620155 660 dbSNP
rs1365341791 662 dbSNP
rs1156739938 667 dbSNP
rs1019849980 668 dbSNP
rs1004152887 673 dbSNP
rs886999410 681 dbSNP
rs1340612489 690 dbSNP
rs911248477 699 dbSNP
rs1026618043 705 dbSNP
rs1252195034 713 dbSNP
rs995170338 721 dbSNP
rs1199016747 722 dbSNP
rs1250129781 725 dbSNP
rs574015320 726 dbSNP
rs894135489 728 dbSNP
rs1445366622 729 dbSNP
rs1055496205 733 dbSNP
rs1200382339 734 dbSNP
rs371665201 735 dbSNP
rs1003015803 739 dbSNP
rs1388280862 742 dbSNP
rs1026167881 757 dbSNP
rs906718878 761 dbSNP
rs1374511311 766 dbSNP
rs1046971557 769 dbSNP
rs1301951510 775 dbSNP
rs994222918 782 dbSNP
rs1454149970 783 dbSNP
rs1317901807 789 dbSNP
rs1363664735 793 dbSNP
rs1228228286 794 dbSNP
rs945655617 795 dbSNP
rs914117025 803 dbSNP
rs1237418587 804 dbSNP
rs1231498904 817 dbSNP
rs1316663883 818 dbSNP
rs1301598534 826 dbSNP
rs1224914284 828 dbSNP
rs1255671452 836 dbSNP
rs1461911699 839 dbSNP
rs771595149 842 dbSNP
rs936689900 843 dbSNP
rs183280013 845 dbSNP
rs1343106063 846 dbSNP
rs1246204343 847 dbSNP
rs921253954 854 dbSNP
rs975519560 869 dbSNP
rs1035853746 871 dbSNP
rs1002230617 877 dbSNP
rs906107846 878 dbSNP
rs1429588147 881 dbSNP
rs965822658 884 dbSNP
rs578035903 886 dbSNP
rs1011212289 887 dbSNP
rs1387362488 887 dbSNP
rs1435172869 906 dbSNP
rs1290021308 917 dbSNP
rs576129369 922 dbSNP
rs866208316 922 dbSNP
rs1300959345 923 dbSNP
rs1324551504 931 dbSNP
rs982989915 932 dbSNP
rs951335561 935 dbSNP
rs1266467148 938 dbSNP
rs1470333189 941 dbSNP
rs1026889956 944 dbSNP
rs1053283244 950 dbSNP
rs1216556120 962 dbSNP
rs1243810730 966 dbSNP
rs761699453 970 dbSNP
rs1487438921 983 dbSNP
rs995368269 987 dbSNP
rs558291238 988 dbSNP
rs538463675 990 dbSNP
rs901708834 994 dbSNP
rs958387499 999 dbSNP
rs1198861397 1001 dbSNP
rs1410741676 1007 dbSNP
rs1400823028 1009 dbSNP
rs367686859 1010 dbSNP
rs1160602993 1013 dbSNP
rs1347485095 1015 dbSNP
rs774327604 1016 dbSNP
rs1447649660 1018 dbSNP
rs1264526418 1019 dbSNP
rs1203874157 1020 dbSNP
rs1456786667 1022 dbSNP
rs1033951306 1033 dbSNP
rs1293310161 1037 dbSNP
rs575904611 1038 dbSNP
rs1346609781 1039 dbSNP
rs1038864332 1040 dbSNP
rs1485756495 1042 dbSNP
rs1002638537 1044 dbSNP
rs1350065228 1055 dbSNP
rs1224431532 1060 dbSNP
rs1286365964 1070 dbSNP
rs768361102 1070 dbSNP
rs556072573 1074 dbSNP
rs749073596 1076 dbSNP
rs1010188867 1080 dbSNP
rs535860230 1081 dbSNP
rs984682898 1083 dbSNP
rs1250657112 1091 dbSNP
rs1054069908 1096 dbSNP
rs1321047299 1099 dbSNP
rs931302187 1101 dbSNP
rs1410899115 1112 dbSNP
rs936889916 1114 dbSNP
rs1422723162 1118 dbSNP
rs918559919 1121 dbSNP
rs1227574198 1126 dbSNP
rs921285379 1131 dbSNP
rs1426987320 1132 dbSNP
rs534734726 1141 dbSNP
rs1040083654 1142 dbSNP
rs944145633 1144 dbSNP
rs567300938 1158 dbSNP
rs1281487344 1168 dbSNP
rs982876300 1173 dbSNP
rs1036293688 1180 dbSNP
rs951244729 1180 dbSNP
rs1315693223 1184 dbSNP
rs919739817 1184 dbSNP
rs980228970 1186 dbSNP
rs1202790159 1198 dbSNP
rs12566673 1203 dbSNP
rs958586036 1204 dbSNP
rs1206261102 1211 dbSNP
rs12566457 1211 dbSNP
rs1002913022 1212 dbSNP
rs571377366 1216 dbSNP
rs3088297 1217 dbSNP
rs747219419 1222 dbSNP
rs1167108155 1225 dbSNP
rs1020487082 1228 dbSNP
rs1410868731 1239 dbSNP
rs551974555 1242 dbSNP
rs1031329338 1243 dbSNP
rs997715721 1244 dbSNP
rs1384923004 1250 dbSNP
rs1374814543 1252 dbSNP
rs1225996354 1254 dbSNP
rs770238137 1257 dbSNP
rs1339898044 1260 dbSNP
rs1039164280 1270 dbSNP
rs1276111068 1274 dbSNP
rs531968750 1275 dbSNP
rs1001131901 1278 dbSNP
rs900052907 1279 dbSNP
rs1039712154 1280 dbSNP
rs1463159325 1282 dbSNP
rs943201817 1283 dbSNP
rs944079061 1284 dbSNP
rs563162709 1285 dbSNP
rs1169966878 1288 dbSNP
rs549693312 1292 dbSNP
rs1195971254 1300 dbSNP
rs1423352980 1301 dbSNP
rs1469430737 1304 dbSNP
rs1177251996 1308 dbSNP
rs1408472290 1317 dbSNP
rs529271487 1340 dbSNP
rs919772297 1341 dbSNP
rs929197781 1347 dbSNP
rs1326919416 1348 dbSNP
rs1432670582 1349 dbSNP
rs1272805884 1357 dbSNP
rs1322412882 1370 dbSNP
rs746253635 1373 dbSNP
rs1340904273 1376 dbSNP
rs1249044686 1378 dbSNP
rs560453105 1390 dbSNP
rs1383509708 1393 dbSNP
rs189940613 1394 dbSNP
rs1207519802 1397 dbSNP
rs972739317 1410 dbSNP
rs769220619 1411 dbSNP
rs927241204 1417 dbSNP
rs758473126 1420 dbSNP
rs1195799714 1421 dbSNP
rs1245277877 1431 dbSNP
rs1480311547 1433 dbSNP
rs1200489386 1436 dbSNP
rs748651479 1443 dbSNP
rs928750418 1448 dbSNP
rs1158023004 1451 dbSNP
rs1450231774 1455 dbSNP
rs1385603582 1458 dbSNP
rs567211686 1460 dbSNP
rs1381736194 1461 dbSNP
rs1336342465 1462 dbSNP
rs1344707092 1466 dbSNP
rs980134328 1466 dbSNP
rs1410703489 1471 dbSNP
rs1348198858 1472 dbSNP
rs540277903 1477 dbSNP
rs1279575251 1488 dbSNP
rs1398729892 1491 dbSNP
rs1270269972 1495 dbSNP
rs1352038371 1499 dbSNP
rs145848446 1506 dbSNP
rs1290198231 1509 dbSNP
rs988978188 1532 dbSNP
rs150277366 1548 dbSNP
rs1223640555 1556 dbSNP
rs1271358269 1562 dbSNP
rs1461543492 1566 dbSNP
rs1032513164 1568 dbSNP
rs1181189105 1572 dbSNP
rs114922608 1573 dbSNP
rs1443190099 1575 dbSNP
rs899992089 1585 dbSNP
rs1364857815 1588 dbSNP
rs1018969072 1589 dbSNP
rs1425102466 1589 dbSNP
rs750686782 1592 dbSNP
rs1439131939 1593 dbSNP
rs1008469297 1594 dbSNP
rs1247961801 1595 dbSNP
rs1337075372 1597 dbSNP
rs767411277 1597 dbSNP
rs1241955070 1601 dbSNP
rs1313602877 1603 dbSNP
rs1359497937 1607 dbSNP
rs879839064 1609 dbSNP
rs1359296059 1612 dbSNP
rs1293919045 1618 dbSNP
rs1294324195 1620 dbSNP
rs891135426 1620 dbSNP
rs1047036801 1622 dbSNP
rs185917242 1631 dbSNP
rs556180690 1634 dbSNP
rs1358501053 1639 dbSNP
rs930065691 1646 dbSNP
rs755328510 1648 dbSNP
rs1038409754 1660 dbSNP
rs1165247292 1671 dbSNP
rs6694569 1677 dbSNP
rs796365526 1677 dbSNP
rs538128247 1682 dbSNP
rs757470543 1682 dbSNP
rs887641750 1682 dbSNP
rs1393822708 1690 dbSNP
rs1444096875 1693 dbSNP
rs3811409 1694 dbSNP
rs1327069467 1698 dbSNP
rs897730046 1701 dbSNP
rs1409345011 1703 dbSNP
rs756986163 1710 dbSNP
rs1306174636 1723 dbSNP
rs1056758241 1724 dbSNP
rs1252143572 1728 dbSNP
rs41271653 1737 dbSNP
rs1166052309 1738 dbSNP
rs1242543612 1755 dbSNP
rs938716182 1756 dbSNP
rs1185403420 1759 dbSNP
rs1385021835 1760 dbSNP
rs949969024 1770 dbSNP
rs1427746343 1807 dbSNP
rs1159566645 1811 dbSNP
rs912906233 1812 dbSNP
rs928589924 1814 dbSNP
rs1464175980 1817 dbSNP
rs1175091610 1820 dbSNP
rs144038653 1822 dbSNP
rs1361745645 1827 dbSNP
rs569824821 1838 dbSNP
rs1180619143 1843 dbSNP
rs1490375986 1844 dbSNP
rs1382033574 1845 dbSNP
rs1270357719 1848 dbSNP
rs768987668 1850 dbSNP
rs957115570 1854 dbSNP
rs1032794455 1856 dbSNP
rs1262735017 1858 dbSNP
rs1324422631 1863 dbSNP
rs1205608203 1864 dbSNP
rs1258923426 1871 dbSNP
rs1485473335 1873 dbSNP
rs1284868074 1877 dbSNP
rs745876324 1880 dbSNP
rs533573323 1885 dbSNP
rs1263500729 1891 dbSNP
rs974485054 1894 dbSNP
rs571341709 1895 dbSNP
rs964591784 1896 dbSNP
rs112398205 1897 dbSNP
rs1370789685 1898 dbSNP
rs557923830 1903 dbSNP
rs551734971 1908 dbSNP
rs1018417786 1920 dbSNP
rs1008915311 1922 dbSNP
rs1227975278 1927 dbSNP
rs1346234995 1928 dbSNP
rs976700867 1937 dbSNP
rs1289964541 1938 dbSNP
rs1304973993 1942 dbSNP
rs372687358 1949 dbSNP
rs1403168949 1954 dbSNP
rs1387669371 1964 dbSNP
rs1403467812 1965 dbSNP
rs955613272 1971 dbSNP
rs1346344776 1974 dbSNP
rs965748100 1974 dbSNP
rs1026074373 1994 dbSNP
rs1017270631 1998 dbSNP
rs1316270027 2002 dbSNP
rs533234131 2003 dbSNP
rs994164011 2005 dbSNP
rs1319520583 2012 dbSNP
rs61818040 2013 dbSNP
rs1007353508 2015 dbSNP
rs1489811024 2017 dbSNP
rs1221413655 2021 dbSNP
rs1269186951 2025 dbSNP
rs368865352 2025 dbSNP
rs898499494 2025 dbSNP
rs951756031 2025 dbSNP
rs1383191509 2026 dbSNP
rs1157999127 2031 dbSNP
rs1027517486 2035 dbSNP
rs1406696022 2035 dbSNP
rs1160531223 2044 dbSNP
rs1430802348 2050 dbSNP
rs538434319 2060 dbSNP
rs897632184 2061 dbSNP
rs1366439010 2063 dbSNP
rs755885441 2063 dbSNP
rs1479807919 2076 dbSNP
rs1242687031 2078 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166 , TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 PAR-CLIP data was present in GSM1462573. RNA binding protein: AGO2. Condition:TZM-bl BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions Prostate Tissue
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in SRX1760639. RNA binding protein: AGO2. Condition:AGO-CLIP-LNCaP-MDV_A ...

- Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al., 2016, Neoplasia (New York, N.Y.).

Article - Hamilton MP; Rajapakshe KI; Bader DA; Cerne et al.
- Neoplasia (New York, N.Y.), 2016
MicroRNA (miRNA) deregulation in prostate cancer (PCa) contributes to PCa initiation and metastatic progression. To comprehensively define the cancer-associated changes in miRNA targeting and function in commonly studied models of PCa, we performed photoactivatable ribonucleoside-enhanced cross-linking immunoprecipitation of the Argonaute protein in a panel of PCa cell lines modeling different stages of PCa progression. Using this comprehensive catalogue of miRNA targets, we analyzed miRNA targeting on known drivers of PCa and examined tissue-specific and stage-specific pathway targeting by miRNAs. We found that androgen receptor is the most frequently targeted PCa oncogene and that miR-148a targets the largest number of known PCa drivers. Globally, tissue-specific and stage-specific changes in miRNA targeting are driven by homeostatic response to active oncogenic pathways. Our findings indicate that, even in advanced PCa, the miRNA pool adapts to regulate continuing alterations in the cancer genome to balance oncogenic molecular changes. These findings are important because they are the first to globally characterize miRNA changes in PCa and demonstrate how the miRNA target spectrum responds to staged tumorigenesis.
LinkOut: [PMID: 27292025]
CLIP-seq Support 1 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000392723.1 | 3UTR | CCCCAUUCUCAACACCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1462573
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl BaL
Location of target site ENST00000392723.1 | 3UTR | CCCCAUUCUCAACACCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
161 hsa-miR-6733-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT075325 SF3B3 splicing factor 3b subunit 3 2 4
MIRT082764 EPN1 epsin 1 2 4
MIRT119868 NRBP1 nuclear receptor binding protein 1 2 2
MIRT124577 PRRC2B proline rich coiled-coil 2B 2 2
MIRT126718 WAC WW domain containing adaptor with coiled-coil 2 2
MIRT128925 KMT2A lysine methyltransferase 2A 2 2
MIRT135191 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 2
MIRT145630 LASP1 LIM and SH3 protein 1 2 2
MIRT175518 ZBTB33 zinc finger and BTB domain containing 33 2 4
MIRT188406 ATXN7L3B ataxin 7 like 3B 2 2
MIRT192486 KNSTRN kinetochore localized astrin/SPAG5 binding protein 2 2
MIRT208383 SLC25A36 solute carrier family 25 member 36 2 2
MIRT216690 F2R coagulation factor II thrombin receptor 2 2
MIRT235839 FAM217B family with sequence similarity 217 member B 2 2
MIRT257000 RGMB repulsive guidance molecule family member b 2 2
MIRT266594 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT273614 SP1 Sp1 transcription factor 2 2
MIRT276567 AKAP11 A-kinase anchoring protein 11 2 2
MIRT285544 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT291540 LRRC8B leucine rich repeat containing 8 VRAC subunit B 2 2
MIRT317159 E2F3 E2F transcription factor 3 2 4
MIRT340688 THRAP3 thyroid hormone receptor associated protein 3 2 2
MIRT366934 OGT O-linked N-acetylglucosamine (GlcNAc) transferase 2 2
MIRT376193 AP1M1 adaptor related protein complex 1 mu 1 subunit 2 2
MIRT441983 TSTD2 thiosulfate sulfurtransferase like domain containing 2 2 2
MIRT442059 POU3F2 POU class 3 homeobox 2 2 6
MIRT443190 PDHA1 pyruvate dehydrogenase E1 alpha 1 subunit 2 2
MIRT445133 CMTM4 CKLF like MARVEL transmembrane domain containing 4 2 2
MIRT445881 WBP1L WW domain binding protein 1 like 2 2
MIRT449359 DPP6 dipeptidyl peptidase like 6 2 2
MIRT451399 FARSA phenylalanyl-tRNA synthetase alpha subunit 2 2
MIRT451802 CDCA3 cell division cycle associated 3 2 4
MIRT452295 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT452494 HMGXB3 HMG-box containing 3 2 2
MIRT453354 ZNF3 zinc finger protein 3 2 2
MIRT453375 CACNA2D2 calcium voltage-gated channel auxiliary subunit alpha2delta 2 2 2
MIRT453719 RAP1GDS1 Rap1 GTPase-GDP dissociation stimulator 1 2 2
MIRT453839 SDK1 sidekick cell adhesion molecule 1 2 2
MIRT454009 ALKBH5 alkB homolog 5, RNA demethylase 2 2
MIRT454371 PIGS phosphatidylinositol glycan anchor biosynthesis class S 2 2
MIRT454729 ARSK arylsulfatase family member K 2 2
MIRT455227 KIAA2013 KIAA2013 2 2
MIRT455866 SLC35C2 solute carrier family 35 member C2 2 2
MIRT456386 KLHL12 kelch like family member 12 2 2
MIRT457017 ACADSB acyl-CoA dehydrogenase, short/branched chain 2 2
MIRT457048 NEGR1 neuronal growth regulator 1 2 2
MIRT457402 BACE2 beta-site APP-cleaving enzyme 2 2 2
MIRT457808 KLHL25 kelch like family member 25 2 2
MIRT458361 C3orf80 chromosome 3 open reading frame 80 2 2
MIRT458678 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT459629 GABARAP GABA type A receptor-associated protein 2 2
MIRT460955 MUL1 mitochondrial E3 ubiquitin protein ligase 1 2 2
MIRT462241 PRSS16 protease, serine 16 2 2
MIRT462472 FIZ1 FLT3 interacting zinc finger 1 2 2
MIRT462572 STS steroid sulfatase 2 2
MIRT462931 ZNF827 zinc finger protein 827 2 2
MIRT463442 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT464129 VPS35 VPS35, retromer complex component 2 2
MIRT464688 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465653 TNPO2 transportin 2 2 2
MIRT465951 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466032 TMEM189 transmembrane protein 189 2 2
MIRT466577 TBC1D2B TBC1 domain family member 2B 2 2
MIRT467506 SMG1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase 2 2
MIRT467786 SLC2A14 solute carrier family 2 member 14 2 2
MIRT468104 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT468292 SFT2D2 SFT2 domain containing 2 2 2
MIRT469004 RNF41 ring finger protein 41 2 2
MIRT469753 RAB2B RAB2B, member RAS oncogene family 2 2
MIRT473205 MINK1 misshapen like kinase 1 2 4
MIRT473314 MEX3A mex-3 RNA binding family member A 2 2
MIRT473549 MAVS mitochondrial antiviral signaling protein 2 2
MIRT474269 LATS2 large tumor suppressor kinase 2 2 2
MIRT475111 IPPK inositol-pentakisphosphate 2-kinase 2 2
MIRT475436 HYOU1 hypoxia up-regulated 1 2 2
MIRT475751 HDLBP high density lipoprotein binding protein 2 2
MIRT475972 GTPBP2 GTP binding protein 2 2 2
MIRT476480 GATAD2A GATA zinc finger domain containing 2A 2 2
MIRT476595 G3BP1 G3BP stress granule assembly factor 1 2 2
MIRT476684 FURIN furin, paired basic amino acid cleaving enzyme 2 2
MIRT477261 ERGIC2 ERGIC and golgi 2 2 2
MIRT477647 EFNA1 ephrin A1 2 2
MIRT477790 E2F2 E2F transcription factor 2 2 2
MIRT477871 DYRK2 dual specificity tyrosine phosphorylation regulated kinase 2 2 2
MIRT478012 DNAJC8 DnaJ heat shock protein family (Hsp40) member C8 2 2
MIRT479558 CDC5L cell division cycle 5 like 2 4
MIRT480420 C17orf85 nuclear cap binding subunit 3 2 2
MIRT480642 BSCL2 BSCL2, seipin lipid droplet biogenesis associated 2 2
MIRT480778 BMP2 bone morphogenetic protein 2 2 2
MIRT481554 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT481689 AR androgen receptor 2 2
MIRT481836 AP1S1 adaptor related protein complex 1 sigma 1 subunit 2 2
MIRT483138 FOXC1 forkhead box C1 2 2
MIRT483919 SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 2 2
MIRT484202 SUMO1 small ubiquitin-like modifier 1 2 2
MIRT484433 RAB7A RAB7A, member RAS oncogene family 2 4
MIRT485544 GP5 glycoprotein V platelet 2 2
MIRT486558 SLC38A4 solute carrier family 38 member 4 2 2
MIRT486727 MGAT5B mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B 2 4
MIRT490490 GLRA3 glycine receptor alpha 3 2 2
MIRT490682 SSTR1 somatostatin receptor 1 2 2
MIRT490792 PSMD3 proteasome 26S subunit, non-ATPase 3 2 2
MIRT491060 ACVR1B activin A receptor type 1B 2 4
MIRT492614 PNRC1 proline rich nuclear receptor coactivator 1 2 2
MIRT492768 PDGFB platelet derived growth factor subunit B 2 2
MIRT493988 EHD1 EH domain containing 1 2 2
MIRT494510 BDNF-AS BDNF antisense RNA 2 2
MIRT494755 AP3M2 adaptor related protein complex 3 mu 2 subunit 2 2
MIRT499802 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT501336 RNF44 ring finger protein 44 2 4
MIRT509490 CENPA centromere protein A 2 2
MIRT509643 ZNF354B zinc finger protein 354B 2 10
MIRT510147 PDGFRA platelet derived growth factor receptor alpha 2 4
MIRT510567 UNG uracil DNA glycosylase 2 6
MIRT525087 FRK fyn related Src family tyrosine kinase 2 2
MIRT528452 NXT2 nuclear transport factor 2 like export factor 2 2 4
MIRT531970 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT532084 RTTN rotatin 2 2
MIRT532756 LDHD lactate dehydrogenase D 2 2
MIRT535072 PPP1R15B protein phosphatase 1 regulatory subunit 15B 2 2
MIRT535637 NPEPPS aminopeptidase puromycin sensitive 2 2
MIRT545410 EIF4A3 eukaryotic translation initiation factor 4A3 2 4
MIRT545911 ZFP91 ZFP91 zinc finger protein 2 4
MIRT548007 GRB2 growth factor receptor bound protein 2 2 4
MIRT548545 DR1 down-regulator of transcription 1 2 2
MIRT550075 TRAPPC2 trafficking protein particle complex 2 2 2
MIRT553730 TBRG1 transforming growth factor beta regulator 1 2 2
MIRT557569 GNPTAB N-acetylglucosamine-1-phosphate transferase alpha and beta subunits 2 2
MIRT558025 EXT1 exostosin glycosyltransferase 1 2 2
MIRT558139 ENC1 ectodermal-neural cortex 1 2 2
MIRT560173 COA1 cytochrome c oxidase assembly factor 1 homolog 2 2
MIRT561700 PTP4A1 protein tyrosine phosphatase type IVA, member 1 2 2
MIRT565101 UBE3C ubiquitin protein ligase E3C 2 2
MIRT565739 SESN3 sestrin 3 2 2
MIRT566669 NACC2 NACC family member 2 2 2
MIRT567040 KCNB1 potassium voltage-gated channel subfamily B member 1 2 2
MIRT569627 ZNF746 zinc finger protein 746 2 2
MIRT570530 RPH3A rabphilin 3A 2 2
MIRT570939 CPE carboxypeptidase E 2 2
MIRT574774 FGF2 fibroblast growth factor 2 2 2
MIRT620120 LACC1 laccase domain containing 1 2 2
MIRT624338 CISD1 CDGSH iron sulfur domain 1 2 2
MIRT625434 RMDN1 regulator of microtubule dynamics 1 2 2
MIRT640528 TET3 tet methylcytosine dioxygenase 3 2 4
MIRT646916 TRIM14 tripartite motif containing 14 2 2
MIRT656298 METTL1 methyltransferase like 1 2 2
MIRT660192 BMPR1A bone morphogenetic protein receptor type 1A 2 2
MIRT661360 DYRK4 dual specificity tyrosine phosphorylation regulated kinase 4 2 2
MIRT667769 KCTD11 potassium channel tetramerization domain containing 11 2 2
MIRT683187 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 2
MIRT685843 ANGEL1 angel homolog 1 2 2
MIRT688553 DCAF16 DDB1 and CUL4 associated factor 16 2 2
MIRT689424 CYB561 cytochrome b561 2 2
MIRT698505 TGFBR1 transforming growth factor beta receptor 1 2 2
MIRT701232 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT702506 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT706488 SEPT6 septin 6 2 2
MIRT713774 ZNF460 zinc finger protein 460 2 2
MIRT716991 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 2 2
MIRT722644 MPEG1 macrophage expressed 1 2 2
MIRT725254 PARVB parvin beta 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6733 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-6733 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-6733-5p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-6733-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-6733-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-6733-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)

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