miRTarBase - #MIRT280473


—
pre-miRNA Information
pre-miRNA hsa-mir-8066   
Genomic Coordinates chr4: 101240795 - 101240872
Description Homo sapiens miR-8066 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-8066
Sequence 48| CAAUGUGAUCUUUUGGAUGUA |68
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs931560390 4 dbSNP
rs1189907448 6 dbSNP
rs1347410735 8 dbSNP
rs1422871438 10 dbSNP
rs1281396192 14 dbSNP
rs1236502030 19 dbSNP
rs929291819 20 dbSNP
rs756482594 21 dbSNP
Putative Targets

Gene Information
Gene Symbol UBR7   
Synonyms C14orf130
Description ubiquitin protein ligase E3 component n-recognin 7 (putative)
Transcript NM_175748   
Expression
Putative miRNA Targets on UBR7
3'UTR of UBR7
(miRNA target sites are highlighted)		 
>UBR7|NM_175748|3'UTR
   1 AGTGGAGTATGAAGCTTTCTCATTCAAGCCAATGAAAATGCGCTTCCCATTCTTGGAATAAAAGAGGTGTGGTTCACATT
  81 TGGCCCCCTTTCCGTCCTCCTCTGTTTGGAGAGGCCTCGCGCTCCCTTCATTCTCTTTAGCTGCAGTAGCCACCGTGTGG
 161 ATGCTGACTTCACAGCCAGCGTCCTCTGTGACTCAGCTGATGCAGCTCATTCCACAGACTTCTCCAGTGTACTCCTACTC
 241 CAGTGCACCCAGGGTTATTTGCATAGTTTTTAAGTTTGATTTTGTTTTGAGAAAGCAAATTGGTGTCTTGTTTAATGATC
 321 TGTTATTTCACTCCCAGATGTGTGTGTTTTGCCACAGAGCTGTTGCCTTCCAGAACCTCCTCCGCAGGCATCACGGAAGG
 401 CTCTCTTCCCGTCACCTAGAACCTCTACAGGTCCCCTCGCCCCTATGATCGTGGTGCCTTGGGTCAAAGCTTCCTCAAGC
 481 CTGGTCTGCTCCTTCTTTCACGTCCCTGTTTTCTGAGGTTTGGTCATAGCTTAGAAAGGATCTTGGGGCTTGTTTTCTCT
 561 AGGCCCAACCTCCAGAGTAGCCAGGACTGATGGTTTTCTGGTCTGGATGTCTGTCACAGGCGGAGAGATTAACAGATGAC
 641 AGGGTTGAGGAAGCAAGCCTTTGTTATGAATTTTACTAATACAGTTCAAGTGAAATTTTCGTTCATGATTCTATTGGCAC
 721 TAGAATTAGAATTTCAGTACTGTAGTGCTCACAGGGCTTCCTGGAGAACATTTGCCCGTATACTAGTCCCTTCTCTGCTG
 801 CCTAGAAAACAGACCGGGTCTCACCCCTGTGAAATCTTGGTGGTTTACGAAGTCCTCTGGATTTCTTGATATTATCAGGG
 881 ATATTCATAAGCATATATCAAAAATGGACCTATTTTGATATTCTGTTATGAAAATGTTATTAGAACCCCAATAAATTATT
 961 ATTTTTCCCCCTTGAATCTGCTAAAGAAAACAGATCCTGACTTAGCTTACTTGAAATAAGCAGGGCAGGGAGCCCTGTTT
1041 TGGAAGAGACAGACTGTGGAAGAGATTACAAACAAGGCCCGAGGCTGCACGAATGATGAGTTTTGTGTATATAATGTTAA
1121 TGTCCACCGCCACTTCCCTAACGACTATGAGATCTTTTTTTTGAAGATCCTCATGGAAGGTTGTACAGAGCCCCACATTT
1201 GAGGGGAAGTCCTTTCAGTTGATATGAGATCTCTTTAACACCCCTCAGTCTATGTAGGAAATGCCTTGTGATACATAGAG
1281 AACCCTCAGCTTCTCTCTGCCTCTGGAGGACCAAGGTCTTTCCTGACAGTCGGAGACACACCTTGATGTATGTTAATAAA
1361 AGCATTTCAGGCTGTGGGGCCACCATGTATATTAATACTCCTTATGTGTCCAGCATCTGTGTATTCATTCGAGTGCCCAA
1441 TCCCTGGATGAGATGAACTAGGCCTTATAAAAAGTCAAAGCCTCAAAGAAATGGCACAACCATGTTCTTCGGCACTCAGG
1521 CTCCTAATTGCAGATCCTCACGAAGGGTGGTATGTGGAGCTGGAAGGTCTTGTGGCCACAGGACATGCTGGTGAGCCCTG
1601 AGCTGGCCTTGTGCAGAGGGCTCCGTTCAAAGGCTCGGGGTGTCTTTGAGGTTGTTTATCAAGCTGGGGAACTCTTCCAA
1681 GTCTGACAATGTTTCGAACCCTTTTTGCAAGGTTGCACTATTAGTATACCATCATGTCCGGAAAACTTTTAATCTTCTCA
1761 AATATCTGATGTAACTACCAGAAAGTCCCTTACTTCCTATGACCAATCAGGACCAAGTCTTGGAGGTGATGTGTTACATT
1841 ACGTGCAGCACAATAGTACCGATCAGTTAACTCAGCGCTGAAGGGCTTGTTTTATGAAAGGTACTATTCCTTCTTTCACA
1921 TTAACTGGAAACCTCTTTTTTTACCTGTTGTTCACAACTAGTTTTCTTATTGACTGTATTGGACTGTCTCTTCTTGTAGA
2001 GACTGATTTTGGCCAACATATTAATGCATGTTTTATGCAAAACACAAATATGATATTAGTTGCTTTTAAGGAGTTCTGGC
2081 ATTGTATGTGCATTTTTGTAGAAATTGTTACTGGACTTATAATTACATACTTAACTCTGATCAGGTTTCTGTAAAATTTA
2161 AATAAAACCAATACAAAATAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auguagGUUUUCU--------AGUGUAAc 5'
                :||||||        ||||||| 
Target 5' ttggaaTAAAAGAGGTGTGGTTCACATTt 3'
 53 - 81 149.00 -8.10
2 
miRNA  3' auguagguuuucuAGUGUAAc 5'
                       ||||||| 
Target 5' actattccttcttTCACATTa 3'
 1903 - 1923 140.00 -7.40
3 
miRNA  3' auGUAGGUUUUCUAGUGUAAc 5'
            ::| ||:|:   |||||| 
Target 5' gtTGTACAGAGCCCCACATTt 3'
 1180 - 1200 123.00 -6.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30447380 5 COSMIC
COSN30540862 10 COSMIC
COSN30166804 26 COSMIC
COSN28677184 42 COSMIC
COSN31614229 50 COSMIC
COSN30535491 62 COSMIC
COSN30155122 68 COSMIC
COSN30524962 76 COSMIC
COSN30125940 84 COSMIC
COSN21921336 127 COSMIC
COSN31602257 131 COSMIC
COSN28751209 134 COSMIC
COSN31564715 395 COSMIC
COSN28674634 451 COSMIC
COSN24304917 504 COSMIC
COSN31490337 524 COSMIC
COSN24013463 628 COSMIC
COSN31541294 636 COSMIC
COSN20919644 699 COSMIC
COSN30538808 736 COSMIC
COSN31537354 776 COSMIC
COSN31520311 873 COSMIC
COSN32057959 1082 COSMIC
COSN31555790 1163 COSMIC
COSN7033964 1377 COSMIC
COSN8462208 1546 COSMIC
COSN1666595 1659 COSMIC
COSN6264744 1773 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1056493859 1 dbSNP
rs748090553 2 dbSNP
rs772053948 5 dbSNP
rs772881183 7 dbSNP
rs760560142 8 dbSNP
rs765926324 10 dbSNP
rs201233800 12 dbSNP
rs1009690800 15 dbSNP
rs764847194 16 dbSNP
rs1200906703 17 dbSNP
rs753200443 24 dbSNP
rs758962880 25 dbSNP
rs764699355 26 dbSNP
rs1330419928 30 dbSNP
rs578119981 31 dbSNP
rs777966845 31 dbSNP
rs540653358 32 dbSNP
rs1367951144 35 dbSNP
rs749323598 37 dbSNP
rs781226798 37 dbSNP
rs746105995 39 dbSNP
rs371371104 41 dbSNP
rs2905 42 dbSNP
rs749438374 43 dbSNP
rs771968322 44 dbSNP
rs773251341 45 dbSNP
rs1283199065 47 dbSNP
rs933843290 50 dbSNP
rs746733992 56 dbSNP
rs770794196 57 dbSNP
rs865794641 62 dbSNP
rs1454721214 65 dbSNP
rs776085737 68 dbSNP
rs759278486 69 dbSNP
rs1451141441 70 dbSNP
rs765043281 73 dbSNP
rs775106647 78 dbSNP
rs1050957240 79 dbSNP
rs1173584802 83 dbSNP
rs1325369407 84 dbSNP
rs1419625391 87 dbSNP
rs762598571 90 dbSNP
rs1433654079 94 dbSNP
rs764455564 95 dbSNP
rs902979718 96 dbSNP
rs1366885128 97 dbSNP
rs550348209 98 dbSNP
rs1271128836 100 dbSNP
rs1456045774 101 dbSNP
rs149097119 108 dbSNP
rs868794885 111 dbSNP
rs767937580 116 dbSNP
rs1012522479 119 dbSNP
rs756323395 120 dbSNP
rs772083651 121 dbSNP
rs780296883 121 dbSNP
rs374461804 122 dbSNP
rs368358086 125 dbSNP
rs1353717062 126 dbSNP
rs755072589 131 dbSNP
rs1329059416 132 dbSNP
rs774521080 134 dbSNP
rs1275154469 137 dbSNP
rs1380979605 147 dbSNP
rs966091809 155 dbSNP
rs1004174878 156 dbSNP
rs1164958048 158 dbSNP
rs971666724 163 dbSNP
rs919026359 165 dbSNP
rs1456289834 169 dbSNP
rs111282868 171 dbSNP
rs1317938968 180 dbSNP
rs770578626 181 dbSNP
rs1435364640 182 dbSNP
rs780113562 187 dbSNP
rs1340272355 195 dbSNP
rs1243019461 204 dbSNP
rs781030305 205 dbSNP
rs1336078106 207 dbSNP
rs531404171 209 dbSNP
rs1260772830 210 dbSNP
rs1195684243 211 dbSNP
rs1266313167 214 dbSNP
rs1466258043 217 dbSNP
rs1205959065 220 dbSNP
rs769546428 223 dbSNP
rs10144530 224 dbSNP
rs762508932 225 dbSNP
rs1258204168 230 dbSNP
rs1323125134 233 dbSNP
rs1472220352 235 dbSNP
rs1290082166 236 dbSNP
rs571022931 236 dbSNP
rs1413544431 241 dbSNP
rs1453790072 242 dbSNP
rs1057111587 245 dbSNP
rs1367601185 255 dbSNP
rs896703077 258 dbSNP
rs945370439 264 dbSNP
rs1394701512 265 dbSNP
rs1336545644 266 dbSNP
rs772349303 268 dbSNP
rs1409753973 274 dbSNP
rs1286939482 289 dbSNP
rs768589692 292 dbSNP
rs1331349458 294 dbSNP
rs373123895 304 dbSNP
rs527355457 311 dbSNP
rs1343114230 316 dbSNP
rs1202031003 319 dbSNP
rs774662618 321 dbSNP
rs1482570296 323 dbSNP
rs546707076 327 dbSNP
rs1253833941 331 dbSNP
rs1489150922 336 dbSNP
rs1246785388 339 dbSNP
rs1419193919 352 dbSNP
rs1197550859 354 dbSNP
rs1197520911 355 dbSNP
rs1375634755 356 dbSNP
rs1054312953 358 dbSNP
rs1467258849 360 dbSNP
rs888944067 361 dbSNP
rs1007509192 362 dbSNP
rs1347137564 366 dbSNP
rs567237669 372 dbSNP
rs1376460218 376 dbSNP
rs1429460939 380 dbSNP
rs1306755402 384 dbSNP
rs1376130311 385 dbSNP
rs1392088891 387 dbSNP
rs1402787111 388 dbSNP
rs1333096100 393 dbSNP
rs117470750 395 dbSNP
rs556021583 396 dbSNP
rs145665789 401 dbSNP
rs1434848611 406 dbSNP
rs921234624 411 dbSNP
rs933929325 412 dbSNP
rs1239670473 416 dbSNP
rs746820343 420 dbSNP
rs1276748610 421 dbSNP
rs1480910498 423 dbSNP
rs182774298 426 dbSNP
rs761186524 427 dbSNP
rs1254645319 428 dbSNP
rs1434341538 430 dbSNP
rs984504528 432 dbSNP
rs1389129853 434 dbSNP
rs1449287902 439 dbSNP
rs1167081602 440 dbSNP
rs1355764683 446 dbSNP
rs11621915 451 dbSNP
rs924505830 452 dbSNP
rs1293392731 455 dbSNP
rs918181224 455 dbSNP
rs934480727 458 dbSNP
rs1054161005 459 dbSNP
rs578164135 464 dbSNP
rs1395673192 466 dbSNP
rs12432271 469 dbSNP
rs1042439864 479 dbSNP
rs553921528 484 dbSNP
rs925255394 488 dbSNP
rs1364699992 489 dbSNP
rs1012595869 492 dbSNP
rs1044054643 493 dbSNP
rs906828674 495 dbSNP
rs1003802675 502 dbSNP
rs187170718 503 dbSNP
rs1307792613 505 dbSNP
rs1243993156 506 dbSNP
rs1263557067 508 dbSNP
rs1489194400 514 dbSNP
rs1213741521 515 dbSNP
rs542611749 517 dbSNP
rs1463261506 524 dbSNP
rs1184005465 525 dbSNP
rs1187143231 531 dbSNP
rs1421331257 533 dbSNP
rs779068421 535 dbSNP
rs1186090009 539 dbSNP
rs1285874201 540 dbSNP
rs889842234 544 dbSNP
rs1355857387 548 dbSNP
rs1429432091 551 dbSNP
rs1164727044 565 dbSNP
rs562807926 568 dbSNP
rs1463121891 569 dbSNP
rs1264405505 571 dbSNP
rs1040179261 576 dbSNP
rs1388265738 583 dbSNP
rs1004373003 586 dbSNP
rs1433177889 587 dbSNP
rs1017056295 594 dbSNP
rs1290796356 600 dbSNP
rs1362428850 601 dbSNP
rs1397613748 607 dbSNP
rs1395199113 610 dbSNP
rs1310538699 620 dbSNP
rs962808015 622 dbSNP
rs192321180 623 dbSNP
rs1266937799 629 dbSNP
rs1367127663 648 dbSNP
rs544822953 650 dbSNP
rs1210230976 651 dbSNP
rs1242296882 652 dbSNP
rs896059956 655 dbSNP
rs1486419304 657 dbSNP
rs955552787 659 dbSNP
rs1254755969 668 dbSNP
rs1476470801 669 dbSNP
rs1366407140 683 dbSNP
rs781325523 688 dbSNP
rs745607195 701 dbSNP
rs769738703 702 dbSNP
rs564713343 705 dbSNP
rs1161597571 706 dbSNP
rs1005810013 708 dbSNP
rs1427569877 709 dbSNP
rs533391857 714 dbSNP
rs748960697 723 dbSNP
rs1357369135 728 dbSNP
rs1262506298 730 dbSNP
rs141192831 734 dbSNP
rs1209356853 739 dbSNP
rs1354479599 743 dbSNP
rs1415331843 743 dbSNP
rs567195222 746 dbSNP
rs1348116904 747 dbSNP
rs1234163961 753 dbSNP
rs1224933189 754 dbSNP
rs1284576999 755 dbSNP
rs529694474 756 dbSNP
rs768250690 757 dbSNP
rs1278637466 758 dbSNP
rs773905867 760 dbSNP
rs1189299791 761 dbSNP
rs1393022325 776 dbSNP
rs989960362 778 dbSNP
rs1043640 779 dbSNP
rs1179005092 782 dbSNP
rs966972714 785 dbSNP
rs765626191 787 dbSNP
rs1174144116 791 dbSNP
rs1377065843 807 dbSNP
rs35291676 811 dbSNP
rs978336219 813 dbSNP
rs752259217 816 dbSNP
rs906907765 817 dbSNP
rs760331518 818 dbSNP
rs1368606551 819 dbSNP
rs540736400 823 dbSNP
rs199998124 828 dbSNP
rs1366206668 829 dbSNP
rs766736008 837 dbSNP
rs1305111597 838 dbSNP
rs1350543768 839 dbSNP
rs1479069419 840 dbSNP
rs1374197568 843 dbSNP
rs1212006986 845 dbSNP
rs754005972 849 dbSNP
rs759795619 850 dbSNP
rs765447742 856 dbSNP
rs1233532733 867 dbSNP
rs757789580 870 dbSNP
rs911309489 875 dbSNP
rs1397081033 882 dbSNP
rs1481837324 889 dbSNP
rs1454584740 908 dbSNP
rs1004446812 912 dbSNP
rs1257160347 914 dbSNP
rs1017120424 922 dbSNP
rs1256120071 922 dbSNP
rs1341241150 924 dbSNP
rs538517430 926 dbSNP
rs1411595035 928 dbSNP
rs781233990 930 dbSNP
rs1348818053 931 dbSNP
rs901682935 937 dbSNP
rs1327550653 938 dbSNP
rs1371253716 947 dbSNP
rs1028817004 948 dbSNP
rs558424777 949 dbSNP
rs1441171468 951 dbSNP
rs929260894 952 dbSNP
rs1297318644 954 dbSNP
rs1337784864 955 dbSNP
rs1467464778 956 dbSNP
rs750387009 956 dbSNP
rs1274270590 958 dbSNP
rs1172435263 962 dbSNP
rs1397693502 962 dbSNP
rs1031648425 963 dbSNP
rs111686048 967 dbSNP
rs144965988 969 dbSNP
rs1194388811 970 dbSNP
rs989991659 971 dbSNP
rs1453453790 972 dbSNP
rs755912011 975 dbSNP
rs914409442 977 dbSNP
rs1188090442 979 dbSNP
rs1371141324 981 dbSNP
rs1200795806 982 dbSNP
rs1476242437 983 dbSNP
rs948554172 987 dbSNP
rs1168456061 988 dbSNP
rs1273467370 990 dbSNP
rs1317176268 996 dbSNP
rs1412940119 1003 dbSNP
rs1403148230 1004 dbSNP
rs75560192 1006 dbSNP
rs1281801177 1007 dbSNP
rs1394851504 1024 dbSNP
rs1433914549 1025 dbSNP
rs1033320530 1030 dbSNP
rs928361847 1033 dbSNP
rs894915269 1039 dbSNP
rs938386566 1041 dbSNP
rs1325076220 1049 dbSNP
rs558731411 1051 dbSNP
rs1271331608 1056 dbSNP
rs185012670 1058 dbSNP
rs1231598824 1062 dbSNP
rs1333999602 1064 dbSNP
rs1275129949 1065 dbSNP
rs116569180 1070 dbSNP
rs778481211 1077 dbSNP
rs1259868195 1078 dbSNP
rs978220104 1081 dbSNP
rs17128946 1082 dbSNP
rs1038627757 1084 dbSNP
rs1236894554 1090 dbSNP
rs898697553 1091 dbSNP
rs997002958 1092 dbSNP
rs1417972902 1097 dbSNP
rs1456206133 1102 dbSNP
rs1470670394 1110 dbSNP
rs780985865 1112 dbSNP
rs768528988 1114 dbSNP
rs1402863586 1120 dbSNP
rs1463176633 1125 dbSNP
rs117127152 1129 dbSNP
rs575957566 1130 dbSNP
rs1413487100 1133 dbSNP
rs1259463046 1137 dbSNP
rs1295600478 1138 dbSNP
rs563177846 1141 dbSNP
rs544886643 1143 dbSNP
rs944159157 1144 dbSNP
rs976857302 1153 dbSNP
rs1350996985 1154 dbSNP
rs776439531 1155 dbSNP
rs1446214182 1158 dbSNP
rs1173764531 1163 dbSNP
rs1353099300 1164 dbSNP
rs1008283349 1165 dbSNP
rs1313953746 1171 dbSNP
rs1277664240 1173 dbSNP
rs1484536319 1174 dbSNP
rs747530904 1176 dbSNP
rs1399949597 1179 dbSNP
rs1258093996 1187 dbSNP
rs1358692118 1189 dbSNP
rs564778292 1191 dbSNP
rs1401467804 1195 dbSNP
rs1470192825 1196 dbSNP
rs1472004434 1198 dbSNP
rs771489940 1210 dbSNP
rs779797219 1218 dbSNP
rs776978075 1223 dbSNP
rs1470309969 1231 dbSNP
rs1171576574 1232 dbSNP
rs1375243195 1234 dbSNP
rs887706818 1239 dbSNP
rs759861920 1240 dbSNP
rs113232027 1241 dbSNP
rs35241574 1241 dbSNP
rs1376570516 1242 dbSNP
rs1409351806 1244 dbSNP
rs1487954458 1245 dbSNP
rs1304954908 1247 dbSNP
rs1260368681 1249 dbSNP
rs1337546575 1254 dbSNP
rs748314848 1279 dbSNP
rs969894232 1281 dbSNP
rs1364427872 1283 dbSNP
rs1345513671 1285 dbSNP
rs1337338102 1292 dbSNP
rs571904728 1296 dbSNP
rs386780108 1298 dbSNP
rs11547258 1299 dbSNP
rs74709229 1300 dbSNP
rs747208804 1302 dbSNP
rs529727208 1309 dbSNP
rs549777069 1310 dbSNP
rs1290682065 1325 dbSNP
rs542708714 1327 dbSNP
rs1252064140 1331 dbSNP
rs1419099170 1332 dbSNP
rs372215863 1333 dbSNP
rs1392844711 1334 dbSNP
rs1463222086 1340 dbSNP
rs1453018127 1343 dbSNP
rs532086618 1345 dbSNP
rs1165464357 1350 dbSNP
rs1395998396 1351 dbSNP
rs1477442673 1359 dbSNP
rs941667717 1363 dbSNP
rs766456857 1374 dbSNP
rs753645086 1377 dbSNP
rs1392219873 1381 dbSNP
rs1214535756 1386 dbSNP
rs754753155 1392 dbSNP
rs1368893505 1406 dbSNP
rs1245640740 1407 dbSNP
rs1236322874 1411 dbSNP
rs1242325195 1414 dbSNP
rs552103098 1417 dbSNP
rs1218914299 1418 dbSNP
rs778590265 1420 dbSNP
rs747761467 1422 dbSNP
rs757847568 1423 dbSNP
rs571924450 1427 dbSNP
rs1208893896 1429 dbSNP
rs985729240 1431 dbSNP
rs1018726484 1432 dbSNP
rs1273214062 1437 dbSNP
rs1050361019 1438 dbSNP
rs1254158953 1439 dbSNP
rs1443372736 1441 dbSNP
rs965417061 1443 dbSNP
rs534415677 1446 dbSNP
rs1008731895 1448 dbSNP
rs559720048 1451 dbSNP
rs1375169104 1458 dbSNP
rs918692175 1459 dbSNP
rs1172376819 1460 dbSNP
rs1053206904 1469 dbSNP
rs1423854233 1480 dbSNP
rs1164489325 1482 dbSNP
rs1455285061 1485 dbSNP
rs11547259 1493 dbSNP
rs1443183480 1495 dbSNP
rs1326724330 1498 dbSNP
rs567767065 1501 dbSNP
rs1380490773 1507 dbSNP
rs36061448 1507 dbSNP
rs1297390995 1511 dbSNP
rs909031054 1512 dbSNP
rs1243529006 1513 dbSNP
rs536324927 1516 dbSNP
rs1011519800 1518 dbSNP
rs190652544 1519 dbSNP
rs1276552302 1520 dbSNP
rs576018622 1521 dbSNP
rs777056396 1522 dbSNP
rs538595298 1524 dbSNP
rs746199674 1525 dbSNP
rs1286995248 1526 dbSNP
rs1371856640 1527 dbSNP
rs1329139407 1529 dbSNP
rs1444861286 1537 dbSNP
rs1001432505 1542 dbSNP
rs1035943272 1543 dbSNP
rs959895518 1546 dbSNP
rs1171705142 1550 dbSNP
rs1429481295 1555 dbSNP
rs193051205 1558 dbSNP
rs770053699 1560 dbSNP
rs1463249693 1563 dbSNP
rs1165698996 1571 dbSNP
rs1157612812 1578 dbSNP
rs1344709924 1586 dbSNP
rs1451466275 1588 dbSNP
rs1290565507 1589 dbSNP
rs184548153 1596 dbSNP
rs1413924987 1602 dbSNP
rs1291259453 1603 dbSNP
rs1178180932 1608 dbSNP
rs1483141544 1611 dbSNP
rs1356937444 1615 dbSNP
rs1233552609 1621 dbSNP
rs1282877259 1625 dbSNP
rs902293218 1626 dbSNP
rs983637761 1627 dbSNP
rs1263008587 1634 dbSNP
rs1486509196 1637 dbSNP
rs999257841 1637 dbSNP
rs3742709 1638 dbSNP
rs963062984 1641 dbSNP
rs1255888195 1643 dbSNP
rs1476282563 1644 dbSNP
rs1188939301 1645 dbSNP
rs1407264404 1646 dbSNP
rs1308856889 1649 dbSNP
rs893967342 1652 dbSNP
rs560899145 1658 dbSNP
rs763069234 1662 dbSNP
rs1161447067 1669 dbSNP
rs756272529 1672 dbSNP
rs973082608 1674 dbSNP
rs570283679 1678 dbSNP
rs998156393 1680 dbSNP
rs1201391802 1681 dbSNP
rs1025585352 1692 dbSNP
rs543142595 1696 dbSNP
rs1377066748 1697 dbSNP
rs951485966 1702 dbSNP
rs1249370987 1707 dbSNP
rs932904406 1711 dbSNP
rs1486325021 1713 dbSNP
rs1262530926 1717 dbSNP
rs1414952567 1719 dbSNP
rs1049970381 1732 dbSNP
rs538023871 1740 dbSNP
rs944212560 1741 dbSNP
rs1224948974 1742 dbSNP
rs1307139433 1747 dbSNP
rs909082011 1747 dbSNP
rs1355004463 1750 dbSNP
rs1244335564 1753 dbSNP
rs563323047 1755 dbSNP
rs991019499 1760 dbSNP
rs77806463 1762 dbSNP
rs1356053887 1763 dbSNP
rs949297385 1768 dbSNP
rs1164306525 1770 dbSNP
rs1486860803 1772 dbSNP
rs1366497987 1777 dbSNP
rs947452660 1780 dbSNP
rs1211346846 1786 dbSNP
rs1232504086 1790 dbSNP
rs1479807674 1792 dbSNP
rs552164410 1794 dbSNP
rs1408841883 1798 dbSNP
rs1453668845 1800 dbSNP
rs1392735899 1803 dbSNP
rs1171694817 1805 dbSNP
rs1396890128 1809 dbSNP
rs565591048 1818 dbSNP
rs527949624 1819 dbSNP
rs1352373316 1831 dbSNP
rs1046120346 1836 dbSNP
rs1443965568 1840 dbSNP
rs762032883 1843 dbSNP
rs759757183 1844 dbSNP
rs1306497639 1850 dbSNP
rs1234117583 1856 dbSNP
rs1301873463 1857 dbSNP
rs1262530387 1860 dbSNP
rs572701901 1861 dbSNP
rs138832733 1862 dbSNP
rs1271004096 1863 dbSNP
rs1272790694 1865 dbSNP
rs1305943804 1866 dbSNP
rs1206914988 1875 dbSNP
rs753751876 1877 dbSNP
rs754737810 1878 dbSNP
rs1327668442 1886 dbSNP
rs1040250262 1898 dbSNP
rs1191894212 1901 dbSNP
rs764957603 1903 dbSNP
rs1374838437 1904 dbSNP
rs1254795646 1909 dbSNP
rs1368391795 1910 dbSNP
rs1035602770 1916 dbSNP
rs1462253137 1922 dbSNP
rs1400038556 1930 dbSNP
rs1166608349 1931 dbSNP
rs1167068259 1932 dbSNP
rs1417157761 1933 dbSNP
rs1411240041 1934 dbSNP
rs1170714923 1936 dbSNP
rs998372358 1936 dbSNP
rs895666918 1937 dbSNP
rs1452786584 1938 dbSNP
rs1025637886 1941 dbSNP
rs1393361496 1943 dbSNP
rs765787449 1949 dbSNP
rs1272097677 1951 dbSNP
rs1438060068 1953 dbSNP
rs1194000147 1954 dbSNP
rs1004699312 1956 dbSNP
rs1373789438 1960 dbSNP
rs567740909 1968 dbSNP
rs951373788 1971 dbSNP
rs752598365 1977 dbSNP
rs963136097 1979 dbSNP
rs1216476658 1986 dbSNP
rs973115334 1995 dbSNP
rs959019404 1996 dbSNP
rs1334507451 1999 dbSNP
rs1441201795 2003 dbSNP
rs990681373 2004 dbSNP
rs1327352762 2015 dbSNP
rs1275164002 2018 dbSNP
rs1452062504 2021 dbSNP
rs111332902 2025 dbSNP
rs1192402918 2029 dbSNP
rs1240076792 2031 dbSNP
rs758044159 2041 dbSNP
rs1194188753 2047 dbSNP
rs1174482605 2048 dbSNP
rs1396981734 2048 dbSNP
rs916381486 2049 dbSNP
rs1459580858 2050 dbSNP
rs141572489 2052 dbSNP
rs1028666434 2057 dbSNP
rs1251099769 2058 dbSNP
rs751050574 2059 dbSNP
rs1345050236 2073 dbSNP
rs536793555 2074 dbSNP
rs1234569985 2082 dbSNP
rs1325269967 2087 dbSNP
rs1433301947 2091 dbSNP
rs986151026 2105 dbSNP
rs1183123296 2107 dbSNP
rs1279281261 2108 dbSNP
rs1446600904 2113 dbSNP
rs923821261 2116 dbSNP
rs934988777 2121 dbSNP
rs912801448 2123 dbSNP
rs1231712092 2128 dbSNP
rs1295142316 2133 dbSNP
rs944228243 2133 dbSNP
rs769725540 2134 dbSNP
rs1357149620 2136 dbSNP
rs549859886 2145 dbSNP
rs988959061 2146 dbSNP
rs188295374 2147 dbSNP
rs1160542336 2155 dbSNP
rs1204697826 2167 dbSNP
rs913375859 2175 dbSNP
rs775848609 2176 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' auguagguuuucuAGUGUAAc 5'
                       ||||||| 
Target 5' acuauuccuucuuUCACAUUa 3'
 		2 - 22
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000013070.6 | 3UTR | UACUAUUCCUUCUUUCACAUUAACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
92 hsa-miR-8066 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT060588 CCND1 cyclin D1 2 2
MIRT067440 RIMKLB ribosomal modification protein rimK like family member B 2 2
MIRT078862 WBP2 WW domain binding protein 2 2 2
MIRT088062 UBXN2A UBX domain protein 2A 2 4
MIRT088214 NUP50 nucleoporin 50 2 2
MIRT103494 HOXA3 homeobox A3 2 8
MIRT135196 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 4
MIRT177727 REEP3 receptor accessory protein 3 2 2
MIRT179439 TBRG1 transforming growth factor beta regulator 1 2 4
MIRT191647 SLC39A9 solute carrier family 39 member 9 2 2
MIRT192342 KLF13 Kruppel like factor 13 2 2
MIRT212035 RAPGEF2 Rap guanine nucleotide exchange factor 2 2 2
MIRT215387 CREBRF CREB3 regulatory factor 2 2
MIRT235001 IER2 immediate early response 2 2 2
MIRT238793 TPD52L1 tumor protein D52 like 1 2 2
MIRT273384 SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 2 4
MIRT280473 UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2 2
MIRT298320 SLC5A3 solute carrier family 5 member 3 2 2
MIRT309180 SPATA5 spermatogenesis associated 5 2 2
MIRT354483 LRRC58 leucine rich repeat containing 58 2 2
MIRT354710 SLC25A36 solute carrier family 25 member 36 2 2
MIRT361004 CDC5L cell division cycle 5 like 2 4
MIRT366247 VMA21 VMA21, vacuolar ATPase assembly factor 2 2
MIRT405774 EIF5 eukaryotic translation initiation factor 5 2 2
MIRT442640 TBC1D12 TBC1 domain family member 12 2 2
MIRT443928 ZNF99 zinc finger protein 99 2 2
MIRT454287 FXN frataxin 2 2
MIRT454367 ASAH2 N-acylsphingosine amidohydrolase 2 2 2
MIRT463574 ZBTB39 zinc finger and BTB domain containing 39 2 6
MIRT464484 UGCG UDP-glucose ceramide glucosyltransferase 2 2
MIRT466866 STX6 syntaxin 6 2 2
MIRT467283 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT470298 PPTC7 PTC7 protein phosphatase homolog 2 2
MIRT471630 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 2
MIRT472802 MTMR4 myotubularin related protein 4 2 4
MIRT474708 KIF3A kinesin family member 3A 2 2
MIRT478256 DDX3X DEAD-box helicase 3, X-linked 2 2
MIRT479330 CERS2 ceramide synthase 2 2 2
MIRT480658 BSCL2 BSCL2, seipin lipid droplet biogenesis associated 2 2
MIRT481954 ANKRD11 ankyrin repeat domain 11 2 2
MIRT482895 IAH1 isoamyl acetate-hydrolyzing esterase 1 homolog 2 4
MIRT493634 HIC2 HIC ZBTB transcriptional repressor 2 2 2
MIRT500847 SYPL1 synaptophysin like 1 2 4
MIRT502035 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
MIRT502185 IGSF3 immunoglobulin superfamily member 3 2 4
MIRT502605 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 10
MIRT502977 CCNL1 cyclin L1 2 8
MIRT504725 PLEKHA6 pleckstrin homology domain containing A6 2 10
MIRT504778 CLEC2D C-type lectin domain family 2 member D 2 4
MIRT505786 SATB1 SATB homeobox 1 2 4
MIRT510090 PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2 4
MIRT520010 YY1 YY1 transcription factor 2 4
MIRT532552 TXNL1 thioredoxin like 1 2 2
MIRT533433 TRPS1 transcriptional repressor GATA binding 1 2 2
MIRT537459 FAM84B family with sequence similarity 84 member B 2 2
MIRT541825 SV2B synaptic vesicle glycoprotein 2B 2 2
MIRT543222 TMEM117 transmembrane protein 117 2 2
MIRT551088 DDX52 DExD-box helicase 52 2 2
MIRT551500 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT552326 ZNF791 zinc finger protein 791 2 2
MIRT553213 TXLNG taxilin gamma 2 2
MIRT554590 RRAGC Ras related GTP binding C 2 2
MIRT559004 CA8 carbonic anhydrase 8 2 2
MIRT559134 BTG3 BTG anti-proliferation factor 3 2 4
MIRT559409 GDNF glial cell derived neurotrophic factor 2 4
MIRT560678 SRFBP1 serum response factor binding protein 1 2 2
MIRT560954 POTED POTE ankyrin domain family member D 2 2
MIRT562856 C17orf58 chromosome 17 open reading frame 58 2 2
MIRT563003 MOCS2 molybdenum cofactor synthesis 2 2 2
MIRT564545 CCDC80 coiled-coil domain containing 80 2 2
MIRT566272 PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2 2
MIRT566510 PAWR pro-apoptotic WT1 regulator 2 2
MIRT572103 EFNB2 ephrin B2 2 2
MIRT574576 NLGN4X neuroligin 4, X-linked 2 4
MIRT576574 Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 2 2
MIRT610815 POT1 protection of telomeres 1 2 2
MIRT624589 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT627567 SMAD6 SMAD family member 6 2 2
MIRT632675 MTX3 metaxin 3 2 2
MIRT689265 WDR83OS WD repeat domain 83 opposite strand 2 2
MIRT694310 COPB2 coatomer protein complex subunit beta 2 2 2
MIRT697721 USP8 ubiquitin specific peptidase 8 2 2
MIRT700209 RFWD3 ring finger and WD repeat domain 3 2 2
MIRT704399 CTSS cathepsin S 2 2
MIRT710665 CSTF2T cleavage stimulation factor subunit 2 tau variant 2 2
MIRT711953 SLC7A14 solute carrier family 7 member 14 2 2
MIRT712596 ADCYAP1 adenylate cyclase activating polypeptide 1 2 2
MIRT712692 TNFAIP2 TNF alpha induced protein 2 2 2
MIRT714171 PPP1R2 protein phosphatase 1 regulatory inhibitor subunit 2 2 2
MIRT715964 CES4A carboxylesterase 4A 2 2
MIRT722781 PDE3A phosphodiesterase 3A 2 2
MIRT724505 MSMO1 methylsterol monooxygenase 1 2 2

Error report submission