| pre-miRNA Information | |
|---|---|
| pre-miRNA | hsa-mir-137 |
| Genomic Coordinates | chr1: 98046070 - 98046171 |
| Description | Homo sapiens miR-137 stem-loop |
| Comment | This miRNA sequence is predicted based on homology to a verified miRNA from mouse . |
| RNA Secondary Structure |  |
| Associated Diseases |  |
| Mature miRNA Information | |
|---|---|
| Mature miRNA | hsa-miR-137 |
| Sequence | 59| UUAUUGCUUAAGAAUACGCGUAG |81 |
| Evidence | Experimental |
| Experiments | Cloned |
| Putative Targets | |
| miRNA Expression profile | |
|---|---|
| Human miRNA Tissue Atlas | |
| miRNAs in Extracellular Vesicles |
|
| Circulating MicroRNA Expression Profiling | |
| Biomarker Information |
| ||||||
|---|---|---|---|---|---|---|---|
| Gene Information | |||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene Symbol | BCL11B | ||||||||||||||||||||
| Synonyms | ATL1, ATL1-alpha, ATL1-beta, ATL1-delta, ATL1-gamma, CTIP-2, CTIP2, IMD49, RIT1, ZNF856B, hRIT1-alpha | ||||||||||||||||||||
| Description | B-cell CLL/lymphoma 11B | ||||||||||||||||||||
| Transcript | NM_022898 | ||||||||||||||||||||
| Other Transcripts | NM_138576 | ||||||||||||||||||||
| Expression | |||||||||||||||||||||
| Putative miRNA Targets on BCL11B | |||||||||||||||||||||
| 3'UTR of BCL11B (miRNA target sites are highlighted) |
>BCL11B|NM_022898|3'UTR 1 GCGCGCGGGCCCCGGCGCCCCGCACCTGTACAGTGGAACCGTTGCCAACCGAGAGAATGCTGACCTGACTTGCCTCCGTG 81 TCACCGCCACCCCGCACCCCGCGTGTCCCCGGGGCCCAGGGGAGGCGGCACTCCAACCTAACCTGTGTCTGCGAAGTCCT 161 ATGGAAACCCGAGGGTTGATTAAGGCAGTACAAATTGTGGAGCCTTTTAACTGTGCAATAATTTCTGTATTTATTGGGTT 241 TTGTAATTTTTTTGGCATGTGCAGGTACTTTTTATTATTATTTTTTCTGTTTGAATTCCTTTAAGAGATTTTGTTGGGTA 321 TCCATCCCTTCTTTGTTTTTTTTTTAACCCGGTAGTAGCCTGAGCAATGACTCGCAAGCAATGTTAGAGGGGAAGCATAT 401 CTTTTAAATTATAATTTGGGGGGAGGGGTGGTGCTGCTTTTTTGAAATTTAAGCTAAGCATGTGTAATTTCTTGTGAAGA 481 AGCCAACACTCAAATGACTTTTAAAGTTGTTTACTTTTTCATTCCTTCCTTTTTTTTGTCCTGAAATAAAAAGTGGCATG 561 CAGTTTTTTTTTTAATTATTTTTTAATTTTTTTTTTGGTTTTTGTTTTTGGGGTGGGGGGTGTGGATGTACAGCGGATAA 641 CAATCTTTCAAGTCGTAGCACTTTGTTTCAGAACTGGAATGGAGATGTAGCACTCATGTCGTCCCGAGTCAAGCGGCCTT 721 TTCTGTGTTGATTTCGGCTTTCATATTACATAAGGGAAACCTTGAGTGGTGGTGCTGGGGGAGGCACCCCACAGACTCAG 801 CGCCGCCAGAGATAGGGTTTTTGGAGGGCTCCTCTGGGAAATGGCCCGACAGCATTCTGAGGTTGTGCATGACCAGCAGA 881 TACTATCCTGTTGGTGTGCCCTGGGGTGCCATGGCTGCTATTCGCTGTAGATTAGGCTACATAAAATGGGCTGAGGGTAC 961 CTTTTTGGGGAGATGGGGTGGCCTGCAGTGACACAGAAAGGAAGAAACTAGCGGTGTTCTTTTAGGCGTTTTCTGGCTTG 1041 ACGGCTTCTCTCTTTTTTTAAATCACCCCCACCACATAAATCTCAAATCCTATGTTGCTACAAGGGGTCATCCATCATTT 1121 CCCAAGCAGACGAATGCCCTAATTAATTGAAGTTAGTGTTCTCTCATTTAATGCACACTGATGATATTGTAGGGATGGGT 1201 GGGGTGGGGATCTTGCAAATTTCTATTCTCTTTTACTGAAAAAGCAGGGGATGAGTTCCATCAGAAGGTGCCCAGCGCTA 1281 CTTCCCAGGTTTTTATTTTTTTTTTCCTATCTCATTAGGTTGGAAGGTACTAAATATTGAACTGTTAAGATTAGACATTT 1361 GAATTCTGTTGACCCGCACTTTAAAGCTTTTGTTTGCATTTAAATTAAATGGCTTCTAAACAAGAAATTGCAGCATATTC 1441 TTCTCTTTGGCCCAGAGGTGGGTTAAACTGTAAGGGACAGCTGAGATTGAGTGTCAGTATTGCTAAGCGTGGCATTCACA 1521 ATACTGGCACTATAAAGAACAAAATAAAATAATAATTTATAGGACAGTTTTTCTACTGCCATTCAATTTGATGTGAGTGC 1601 CTTGAAAACTGATCTTCCTATTTGAGTCTCTTGAGACAAATGCAAAACTTTTTTTTTGAAATGAAAAGACTTTTTAAAAA 1681 AGTAAAACAAGAAAAGTACATTCTTTAGAAACTAACAAAGCCACATTTACTTTAAGTAAAAAAAAAAAAAATTCTGGTTG 1761 AAGATAGAGGATATGAAATGCCATAAGACCCAATCAAATGAAGAAATAAACCCAGCACAACCTTGGACATCCATTAGCTG 1841 AATTATCCTCAGCCCCTTTTGTTTTTGGGACAACGCTGCTTAGATATGGAGTGGAGGTGATTTACTGCTGAATTAAAACT 1921 CAAGTGACACAAGTTACAAGTTGATATCGTTGAATGAAAAGCAAAACAAAAACAATTCAGGAACAACGGCTAATTTTTTC 2001 TAAAGTTAAATTTAGTGCACTCTGTCTTAAAAATACGTTTACAGTATTGGGTACATACAAGGGTAAAAAAAAAATTGTGT 2081 GTATGTGTGTTGGAGCGATCTTTTTTTTTCAAAGTTTGCTTAATAGGTTATACAAAAATGCCACAGTGGCCGCGTGTATA 2161 TTGTTTTCTTTTGGTGACGGGGTTTTAGTATATATTATATATATTAAAATTTCTTGATTACTGTAAAAGTGGACCAGTAT 2241 TTGTAATAATCGAGAATGCCTGGGCATTTTACAAAACAAGAAAAAAAATACCCTTTTCTTTTCCTTGAAAATGTTGCAGT 2321 AAAATTTAAATGGTGGGTCTATAAATTTGTTCTTGTTACAGTAACTGTAAAGTCGGAGTTTTAGTAAATTTTTTTCTGCC 2401 TTGGGTGTTGAATTTTTATTTCAAAAAAAATGTATAGAAACTTGTATTTGGGGATTCAAAGGGGATTGCTACACCATGTA 2481 GAAAAAGTATGTAGAAAAAAAGTGCTTAATATTGTTATTGCTTTGCAGAAAAAAAAAAAATCACATTTCTGACCTGTACT 2561 TATTTTTCTCTTCCCGCCTCCCTCTGGAATGGATATATTGGTTGGTTCATATGATGTAGGCACTTGCTGTATTTTTACTG 2641 GAGCTCGTAATTTTTTAACTGTAAGCTTGTCCTTTTAAAGGGATTTAATGTACCTTTTTGTTAGTGAATTTGGAAATAAA 2721 AAGAAAAAAAAAACAAAAACAAACAGGCTGCCATAATATATTTTTTTAATTTGGCAGGATAAAATATTGCAAAAAAAACA 2801 CATTTGTATGTTAAGTCCTATTGTACAGGAGAAAAAGGGTTGTTTGACAACCTTTGAGAAAAAGAAACAAAAGGAAGTAG 2881 TTAAATGCTTTGGTTCACAAATCATTTAGTTGTATATATTTTTTGTCGGAATTGGCCTACACAGAGAACCGTTCGTGTTG 2961 GGCTTCTCTCTGAACGCCCCGAACCTTGCATCAAGGCTCCTTGGTGTGGCCACAGCAGACCAGATGGGAAATTATTTGTG 3041 TTGAGTGGAAAAAAATCAGTTTTTGTAAAGATGTCAGTAACATTCCACATCGTCCTCCCTTTCTCTAAGAGGCCATCTCT 3121 AAGATGTCAGATGTAGAGGAGAGAGAGCGAGAGAACATCTTCCTTCTCTACCATCACTCCTGTGGCGGTCACCACCACCA 3201 CCTCTCCCGCCCTTACCAGCAGAAAGCAATGCAAACTGAGCTGCTTTAGTCCTTGAGAAATTGTGAAACAAACACAAATA 3281 TCATAAAAGGAGCTGGTGATTCAGCTGGGTCCAGGTGAAGTGACCTGCTGTTGAGACCGGTACAAATTGGATTTCAGGAA 3361 GGAGACTCCATCACAGCCAGGACCTTTCGTGCCATGGAGAGTGTTGGCCTCTTGTCTTTCTTCCCTGCTTTGCTGCTTTG 3441 CTCTCTGAAACCTACATTCCGTCAGTTTCCGAATGCGAGGGCCTGGGATGAATTTGGTGCCTTTCCATATCTCGTTCTCT 3521 CTCCTTCCCCTGCGTTTCCTCTCCATCCTTCATCCTCCATTGGTCCTTTTTTTTTCTTTCATTTTTTATTTAATTTCTTT 3601 TCTTCCTGTCTGTTCCTCCCCTAATCCTCTATTTTATTTTTATTTTTTGTAAAGCCAAGTAGCTTTAAGATAAAGTGGTG 3681 GTCTTTTGGATGAGGGAATAATGCATTTTTAAATAAAATACCAATATCAGGAAGCCATTTTTTATTTCAGGAAATGTAAG 3761 AAACCATTATTTCAGGTTATGAAAGTATAACCAAGCATCCTTTTGGGCAATTCCTTACCAAATGCAGAAGCTTTTCTGTT 3841 CGATGCACTCTTTCCTCCTTGCCACTTACCTTTGCAAAGTTAAAAAAAAGGGGGGAGGGAATGGGAGAGAAAGCTGAGAT 3921 TTCAGTTTCCTACTGCAGTTTCCTACCTGCAGATCCAGGGGCTGCTGTTGCCTTTGGATGCCCCACTGAGGTCCTAGAGT 4001 GCCTCCAGGGTGGTCTTCCTGTAGTCATAACAGCTAGCCAGTGCTCACCAGCTTACCAGATTGCCAGGACTAAGCCATCC 4081 CAAAGCACAAGCATTGTGTGTCTCTGTGACTGCAGAGAAGAGAGAATTTTGCTTCTGTTTTGTGTTTAAAAAACCAACAC 4161 GGAAGCAGATGATCCCGAGAGAGAGGCCTCTAGCATGGGTGACCCAGCCGACCTCAGGCCGGTTTCCGCACTGCCACAAC 4241 TTTGTTCAAAGTTGCCCCCAATTGGAACCTGCCACTTGGCATTAGAGGGTCTTTCATGGGGAGAGAAGGAGACTGAATTA 4321 CTCTAAGCAAAATGTGAAAAGTAAGGAAATCAGCCTTTCATCCCGGTCCTAAGTAACCGTCAGCCGAAGGTCTCGTGGAA 4401 CACAGGCAAACCCGTGATTTTGGTGCTCCTTGTAACTCAGCCCTGCAAAGCAAAGTCCCATTGATTTAAGTTGTTTGCAT 4481 TTGTACTGGCAAGGCAAAATATTTTTATTACCTTTTCTATTACTTATTGTATGAGCTTTTGTTGTTTACTTGGAGGTTTT 4561 GTCTTTTACTACAAGTTTGGAACTATTTATTATTGCTTGGTATTTGTGCTCTGTTTAAGAAACAGGCACTTTTTTTTATT 4641 ATGGATAAAATGTTGAGATGACAGGAGGTCATTTCAATATGGCTTAGTAAAATATTTATTGTTCCTTTATTCTCTGTACA 4721 AGATTTTGGGCCTCTTTTTTTCCTTAATGTCACAATGTTGAGTTCAGCATGTGTCTGCCATTTCATTTGTACGCTTGTTC 4801 AAAACCAAGTTTGTTCTGGTTTCAAGTTATAAAAATAAATTGGACATTTAACTTGATCTCCAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
|
||||||||||||||||||||
| miRNA-target interactions (Predicted by miRanda) |
|
||||||||||||||||||||
| DRVs in gene 3'UTRs | |||||||||||||||||||||
| SNPs in gene 3'UTRs | |||||||||||||||||||||
| Experimental Support 1 for Functional miRNA-Target Interaction | |
|---|---|
| miRNA:Target | ---- |
| Validation Method |
|
| Conditions | HEK293 |
| Location of target site | 3'UTR |
| Tools used in this research | TargetScan , miRTarCLIP , Piranha |
| Original Description (Extracted from the article) |
...
PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control
PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection
PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection
... - Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell. |
| Article |
- Hafner M; Landthaler M; Burger L; Khorshid et al. - Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
|
| Experimental Support 2 for Functional miRNA-Target Interaction | |
|---|---|
| miRNA:Target | ---- |
| Validation Method |
|
| Conditions | HEK293 |
| Disease | 64919.0 |
| Location of target site | 3'UTR |
| Tools used in this research | TargetScan , miRTarCLIP , Piranha |
| Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1
... - Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods. |
| Article |
- Kishore S; Jaskiewicz L; Burger L; Hausser et al. - Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
|
| Experimental Support 3 for Functional miRNA-Target Interaction | |
|---|---|
| miRNA:Target | ---- |
| Validation Method |
|
| Conditions | HEK293 |
| Disease | 64919.0 |
| Location of target site | 3'UTR |
| Tools used in this research | TargetScan , miRTarCLIP , Piranha |
| Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine
"PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine
... - Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature. |
| Article |
- Memczak S; Jens M; Elefsinioti A; Torti F; et al. - Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
|
| Experimental Support 4 for Functional miRNA-Target Interaction | |
|---|---|
| miRNA:Target | ---- |
| Validation Method |
|
| Conditions | MCF7 |
| Location of target site | 3'UTR |
| Tools used in this research | TargetScan , miRTarCLIP , Piranha |
| Original Description (Extracted from the article) |
...
PAR-CLIP data was present in SRR1045082. RNA binding protein: AGO2. Condition:Untreated
... - Farazi TA; Ten Hoeve JJ; Brown M; et al., 2014, Genome biology. |
| Article |
- Farazi TA; Ten Hoeve JJ; Brown M; et al. - Genome biology, 2014
BACKGROUND: Various microRNAs (miRNAs) are up- or downregulated in tumors. However, the repression of cognate miRNA targets responsible for the phenotypic effects of this dysregulation in patients remains largely unexplored. To define miRNA targets and associated pathways, together with their relationship to outcome in breast cancer, we integrated patient-paired miRNA-mRNA expression data with a set of validated miRNA targets and pathway inference. RESULTS: To generate a biochemically-validated set of miRNA-binding sites, we performed argonaute-2 photoactivatable-ribonucleoside-enhanced crosslinking and immunoprecipitation (AGO2-PAR-CLIP) in MCF7 cells. We then defined putative miRNA-target interactions using a computational model, which ranked and selected additional TargetScan-predicted interactions based on features of our AGO2-PAR-CLIP binding-site data. We subselected modeled interactions according to the abundance of their constituent miRNA and mRNA transcripts in tumors, and we took advantage of the variability of miRNA expression within molecular subtypes to detect miRNA repression. Interestingly, our data suggest that miRNA families control subtype-specific pathways; for example, miR-17, miR-19a, miR-25, and miR-200b show high miRNA regulatory activity in the triple-negative, basal-like subtype, whereas miR-22 and miR-24 do so in the HER2 subtype. An independent dataset validated our findings for miR-17 and miR-25, and showed a correlation between the expression levels of miR-182 targets and overall patient survival. Pathway analysis associated miR-17, miR-19a, and miR-200b with leukocyte transendothelial migration. CONCLUSIONS: We combined PAR-CLIP data with patient expression data to predict regulatory miRNAs, revealing potential therapeutic targets and prognostic markers in breast cancer.
LinkOut: [PMID: 24398324]
|
| CLIP-seq Support 1 for dataset GSM545214 | |
|---|---|
| Method / RBP | PAR-CLIP / AGO3 |
| Cell line / Condition | HEK293 / Control |
| Location of target site | ENST00000357195.3 | 3UTR | CCUUUUAACUGUGCAAUAAUUU |
| Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
| Article / Accession Series | PMID: 20371350 / GSE21578 |
| CLIP-seq Viewer | Link |
| CLIP-seq Support 2 for dataset GSM545216 | |
|---|---|
| Method / RBP | PAR-CLIP / AGO2 |
| Cell line / Condition | HEK293 / miR-124 transfection |
| Location of target site | ENST00000357195.3 | 3UTR | UACAAAUUGUGGAGCCUUUUAACUGUGCAAUAAUUUCU |
| Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
| Article / Accession Series | PMID: 20371350 / GSE21578 |
| CLIP-seq Viewer | Link |
| CLIP-seq Support 3 for dataset GSM545217 | |
|---|---|
| Method / RBP | PAR-CLIP / AGO2 |
| Cell line / Condition | HEK293 / miR-7 transfection |
| Location of target site | ENST00000357195.3 | 3UTR | CCUUUUAACUGUGCAAUAAUUUCU |
| Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
| Article / Accession Series | PMID: 20371350 / GSE21578 |
| CLIP-seq Viewer | Link |
| CLIP-seq Support 4 for dataset GSM714645 | |
|---|---|
| Method / RBP | PAR-CLIP / AGO2 |
| Cell line / Condition | HEK293 / completeT1, repB |
| Location of target site | ENST00000357195.3 | 3UTR | CCUUUUAACUGUGCAAUAAUUUCUG |
| Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
| Article / Accession Series | PMID: 21572407 / GSE28865 |
| CLIP-seq Viewer | Link |
| CLIP-seq Support 5 for dataset GSM1065667 | |
|---|---|
| Method / RBP | PAR-CLIP / AGO1 |
| Cell line / Condition | HEK293 / 4-thiouridine, ML_MM_6 |
| Location of target site | ENST00000357195.3 | 3UTR | CCUUUUAACUGUGCAAUAAUUUCU |
| Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
| Article / Accession Series | PMID: 23446348 / GSE43573 |
| CLIP-seq Viewer | Link |
| CLIP-seq Support 6 for dataset GSM1065670 | |
|---|---|
| Method / RBP | PAR-CLIP / AGO2 |
| Cell line / Condition | HEK293 / 4-thiouridine, 3_ML_LG |
| Location of target site | ENST00000357195.3 | 3UTR | CCUUUUAACUGUGCAAUAAUUU |
| Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
| Article / Accession Series | PMID: 23446348 / GSE43573 |
| CLIP-seq Viewer | Link |
| CLIP-seq Support 7 for dataset SRR1045082 | |
|---|---|
| Method / RBP | PAR-CLIP / AGO2 |
| Cell line / Condition | MCF7 / Untreated |
| Location of target site | ENST00000357195.3 | 3UTR | CCUUUUAACUGUGCAAUAAUUUCUG |
| Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
| Article / Accession Series | PMID: 24398324 / SRX388831 |
| CLIP-seq Viewer | Link |
| MiRNA-Target Expression Profile | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| MiRNA-Target Expression Profile (TCGA) | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
140 hsa-miR-137 Target Genes:
Functional analysis:
ID |
Target | Description | Validation methods |
 |
 |
|||||||
| Strong evidence | Less strong evidence | |||||||||||
 |
 |
 |
 |
 |
 |
 |
 |
|||||
| MIRT002489 | E2F6 | E2F transcription factor 6 |  |
|
|
|
4 | 1 | ||||
| MIRT002490 | CDK6 | cyclin dependent kinase 6 | |
|
|
|
4 | 7 | ||||
| MIRT004004 | NCOA2 | nuclear receptor coactivator 2 | |
|
|
|
4 | 1 | ||||
| MIRT004579 | KDM1A | lysine demethylase 1A | |
|
|
|
|
5 | 3 | |||
| MIRT005485 | CDC42 | cell division cycle 42 | |
|
|
|
4 | 4 | ||||
| MIRT005605 | CTBP1 | C-terminal binding protein 1 | |
|
|
|
4 | 1 | ||||
| MIRT005883 | MITF | melanogenesis associated transcription factor | |
|
|
3 | 1 | |||||
| MIRT006329 | PTGS2 | prostaglandin-endoperoxide synthase 2 | |
|
2 | 1 | ||||||
| MIRT006957 | ESRRA | estrogen related receptor alpha | |
1 | 1 | |||||||
| MIRT007068 | ZNF804A | zinc finger protein 804A | |
1 | 1 | |||||||
| MIRT007092 | YBX1 | Y-box binding protein 1 | |
|
|
3 | 3 | |||||
| MIRT007252 | CSE1L | chromosome segregation 1 like | |
|
2 | 1 | ||||||
| MIRT007346 | PXN | paxillin | |
|
|
3 | 1 | |||||
| MIRT053056 | GLIPR1 | GLI pathogenesis related 1 | |
|
|
3 | 1 | |||||
| MIRT053225 | MET | MET proto-oncogene, receptor tyrosine kinase | |
|
|
3 | 1 | |||||
| MIRT054547 | FUNDC1 | FUN14 domain containing 1 | |
|
|
3 | 1 | |||||
| MIRT054568 | BNIP3L | BCL2 interacting protein 3 like | |
|
|
3 | 1 | |||||
| MIRT090615 | PLS1 | plastin 1 | |
|
2 | 2 | ||||||
| MIRT093393 | TMA16 | translation machinery associated 16 homolog | |
|
2 | 2 | ||||||
| MIRT109230 | VMA21 | VMA21, vacuolar ATPase assembly factor | |
|
2 | 6 | ||||||
| MIRT153687 | NCOA3 | nuclear receptor coactivator 3 | |
|
2 | 2 | ||||||
| MIRT170929 | FOXK1 | forkhead box K1 | |
|
2 | 2 | ||||||
| MIRT219251 | RREB1 | ras responsive element binding protein 1 | |
|
2 | 2 | ||||||
| MIRT259552 | KLHL15 | kelch like family member 15 | |
|
2 | 4 | ||||||
| MIRT271869 | ZNF678 | zinc finger protein 678 | |
|
2 | 2 | ||||||
| MIRT280623 | BCL11B | B-cell CLL/lymphoma 11B | |
|
2 | 8 | ||||||
| MIRT293284 | DR1 | down-regulator of transcription 1 | |
|
2 | 2 | ||||||
| MIRT314017 | PAPD7 | poly(A) RNA polymerase D7, non-canonical | |
|
2 | 8 | ||||||
| MIRT374677 | AGO4 | argonaute 4, RISC catalytic component | |
|
2 | 2 | ||||||
| MIRT437385 | FMNL2 | formin like 2 | |
1 | 1 | |||||||
| MIRT437406 | RORA | RAR related orphan receptor A | |
1 | 1 | |||||||
| MIRT437423 | KIT | KIT proto-oncogene receptor tyrosine kinase | |
|
|
3 | 1 | |||||
| MIRT437424 | AKT2 | AKT serine/threonine kinase 2 | |
|
|
|
|
5 | 4 | |||
| MIRT437425 | TGFB2 | transforming growth factor beta 2 | |
|
|
3 | 1 | |||||
| MIRT437804 | SERPINA3 | serpin family A member 3 | |
1 | 1 | |||||||
| MIRT437978 | COX2 | cytochrome c oxidase subunit II | |
|
|
3 | 1 | |||||
| MIRT438078 | TRIM13 | tripartite motif containing 13 | |
|
|
|
4 | 1 | ||||
| MIRT438287 | TBX3 | T-box 3 | |
1 | 1 | |||||||
| MIRT438288 | KLF4 | Kruppel like factor 4 | |
1 | 1 | |||||||
| MIRT438537 | MTDH | metadherin | |
|
2 | 1 | ||||||
| MIRT438757 | Nr1i3 | nuclear receptor subfamily 1, group I, member 3 | |
|
2 | 1 | ||||||
| MIRT442564 | CCDC59 | coiled-coil domain containing 59 | |
|
2 | 2 | ||||||
| MIRT442778 | JAG1 | jagged 1 | |
|
2 | 2 | ||||||
| MIRT444302 | SREK1IP1 | SREK1 interacting protein 1 | |
|
2 | 2 | ||||||
| MIRT446969 | SLCO4C1 | solute carrier organic anion transporter family member 4C1 | |
|
2 | 2 | ||||||
| MIRT448824 | FKBP1A | FK506 binding protein 1A | |
|
2 | 4 | ||||||
| MIRT453617 | SNRPE | small nuclear ribonucleoprotein polypeptide E | |
|
2 | 4 | ||||||
| MIRT459217 | MRPS21 | mitochondrial ribosomal protein S21 | |
|
2 | 2 | ||||||
| MIRT463490 | ZC3H11A | zinc finger CCCH-type containing 11A | |
|
2 | 12 | ||||||
| MIRT470084 | PTGES2 | prostaglandin E synthase 2 | |
|
2 | 2 | ||||||
| MIRT475876 | H3F3C | H3 histone family member 3C | |
|
2 | 10 | ||||||
| MIRT475912 | H3F3B | H3 histone family member 3B | |
|
2 | 8 | ||||||
| MIRT476669 | FUT11 | fucosyltransferase 11 | |
|
2 | 10 | ||||||
| MIRT477346 | EOGT | EGF domain specific O-linked N-acetylglucosamine transferase | |
|
2 | 4 | ||||||
| MIRT477596 | EIF1 | eukaryotic translation initiation factor 1 | |
|
2 | 10 | ||||||
| MIRT478367 | DDI2 | DNA damage inducible 1 homolog 2 | |
|
2 | 2 | ||||||
| MIRT479111 | CNN2 | calponin 2 | |
|
2 | 2 | ||||||
| MIRT482926 | CTPS2 | CTP synthase 2 | |
|
2 | 2 | ||||||
| MIRT485083 | SNRK | SNF related kinase | |
|
2 | 12 | ||||||
| MIRT497120 | NBEAL1 | neurobeachin like 1 | |
|
2 | 2 | ||||||
| MIRT498029 | UBXN4 | UBX domain protein 4 | |
|
2 | 8 | ||||||
| MIRT500603 | UBE2Z | ubiquitin conjugating enzyme E2 Z | |
|
2 | 4 | ||||||
| MIRT500927 | SSFA2 | sperm specific antigen 2 | |
|
2 | 8 | ||||||
| MIRT504324 | ASGR2 | asialoglycoprotein receptor 2 | |
|
2 | 6 | ||||||
| MIRT504647 | RPL9 | ribosomal protein L9 | |
|
2 | 6 | ||||||
| MIRT506304 | PCMTD1 | protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 | |
|
2 | 6 | ||||||
| MIRT508007 | BCAT1 | branched chain amino acid transaminase 1 | |
|
2 | 4 | ||||||
| MIRT510538 | XKR7 | XK related 7 | |
|
2 | 2 | ||||||
| MIRT513051 | LYPD6 | LY6/PLAUR domain containing 6 | |
|
2 | 6 | ||||||
| MIRT515223 | COX20 | COX20, cytochrome c oxidase assembly factor | |
|
2 | 8 | ||||||
| MIRT519857 | ZFP62 | ZFP62 zinc finger protein | |
|
2 | 6 | ||||||
| MIRT520508 | TRAM2 | translocation associated membrane protein 2 | |
|
2 | 6 | ||||||
| MIRT522047 | PAFAH1B2 | platelet activating factor acetylhydrolase 1b catalytic subunit 2 | |
|
2 | 4 | ||||||
| MIRT524479 | CHRM3 | cholinergic receptor muscarinic 3 | |
|
2 | 4 | ||||||
| MIRT526904 | ZNF772 | zinc finger protein 772 | |
|
2 | 6 | ||||||
| MIRT527862 | SLC39A14 | solute carrier family 39 member 14 | |
|
2 | 2 | ||||||
| MIRT528601 | ZNF326 | zinc finger protein 326 | |
|
2 | 2 | ||||||
| MIRT532950 | ZNF24 | zinc finger protein 24 | |
|
2 | 4 | ||||||
| MIRT536275 | LMOD2 | leiomodin 2 | |
|
2 | 2 | ||||||
| MIRT537045 | GRAMD4 | GRAM domain containing 4 | |
|
2 | 2 | ||||||
| MIRT537124 | GOLGA3 | golgin A3 | |
|
2 | 4 | ||||||
| MIRT538884 | BTBD1 | BTB domain containing 1 | |
|
2 | 2 | ||||||
| MIRT541457 | AURKA | aurora kinase A | |
|
2 | 2 | ||||||
| MIRT542924 | HOXC8 | homeobox C8 | |
|
2 | 2 | ||||||
| MIRT544580 | AP5Z1 | adaptor related protein complex 5 zeta 1 subunit | |
|
2 | 4 | ||||||
| MIRT545175 | RFTN2 | raftlin family member 2 | |
|
2 | 2 | ||||||
| MIRT545248 | GTF2E1 | general transcription factor IIE subunit 1 | |
|
2 | 2 | ||||||
| MIRT546473 | SLC1A5 | solute carrier family 1 member 5 | |
|
2 | 2 | ||||||
| MIRT547523 | MARCH9 | membrane associated ring-CH-type finger 9 | |
|
2 | 2 | ||||||
| MIRT548071 | GIGYF1 | GRB10 interacting GYF protein 1 | |
|
2 | 2 | ||||||
| MIRT548200 | FNIP1 | folliculin interacting protein 1 | |
|
2 | 2 | ||||||
| MIRT551216 | CIDEC | cell death inducing DFFA like effector c | |
|
2 | 2 | ||||||
| MIRT553046 | USP28 | ubiquitin specific peptidase 28 | |
|
2 | 2 | ||||||
| MIRT553875 | SUPT7L | SPT7 like, STAGA complex gamma subunit | |
|
2 | 4 | ||||||
| MIRT554026 | SPCS3 | signal peptidase complex subunit 3 | |
|
2 | 2 | ||||||
| MIRT554153 | SLX4 | SLX4 structure-specific endonuclease subunit | |
|
2 | 2 | ||||||
| MIRT554192 | SLC35E2B | solute carrier family 35 member E2B | |
|
2 | 2 | ||||||
| MIRT554362 | SFXN5 | sideroflexin 5 | |
|
2 | 4 | ||||||
| MIRT555349 | PPP1R37 | protein phosphatase 1 regulatory subunit 37 | |
|
2 | 2 | ||||||
| MIRT555822 | PAX9 | paired box 9 | |
|
2 | 2 | ||||||
| MIRT555866 | PAIP1 | poly(A) binding protein interacting protein 1 | |
|
2 | 2 | ||||||
| MIRT555931 | NUP43 | nucleoporin 43 | |
|
2 | 2 | ||||||
| MIRT555993 | NFYB | nuclear transcription factor Y subunit beta | |
|
2 | 2 | ||||||
| MIRT556429 | LONRF3 | LON peptidase N-terminal domain and ring finger 3 | |
|
2 | 2 | ||||||
| MIRT556582 | LHFPL2 | LHFPL tetraspan subfamily member 2 | |
|
2 | 4 | ||||||
| MIRT557220 | HNRNPDL | heterogeneous nuclear ribonucleoprotein D like | |
|
2 | 2 | ||||||
| MIRT558490 | DBN1 | drebrin 1 | |
|
2 | 2 | ||||||
| MIRT560986 | GPBP1L1 | GC-rich promoter binding protein 1 like 1 | |
|
2 | 2 | ||||||
| MIRT562291 | GLO1 | glyoxalase I | |
|
2 | 2 | ||||||
| MIRT564093 | TLR3 | toll like receptor 3 | |
|
2 | 2 | ||||||
| MIRT565312 | TMEM41A | transmembrane protein 41A | |
|
2 | 2 | ||||||
| MIRT565424 | TEF | TEF, PAR bZIP transcription factor | |
|
2 | 2 | ||||||
| MIRT566946 | LIMCH1 | LIM and calponin homology domains 1 | |
|
2 | 2 | ||||||
| MIRT572369 | ATOX1 | antioxidant 1 copper chaperone | |
|
2 | 2 | ||||||
| MIRT686211 | ZNF267 | zinc finger protein 267 | |
|
2 | 2 | ||||||
| MIRT686935 | SFT2D3 | SFT2 domain containing 3 | |
|
2 | 2 | ||||||
| MIRT687448 | NR3C1 | nuclear receptor subfamily 3 group C member 1 | |
|
2 | 2 | ||||||
| MIRT710856 | COQ7 | coenzyme Q7, hydroxylase | |
|
2 | 2 | ||||||
| MIRT719484 | RBM27 | RNA binding motif protein 27 | |
|
2 | 2 | ||||||
| MIRT719813 | TXNDC17 | thioredoxin domain containing 17 | |
|
2 | 2 | ||||||
| MIRT720076 | YTHDF3 | YTH N6-methyladenosine RNA binding protein 3 | |
|
2 | 2 | ||||||
| MIRT723920 | ADAMTS15 | ADAM metallopeptidase with thrombospondin type 1 motif 15 | |
|
2 | 2 | ||||||
| MIRT731305 | CUL4A | cullin 4A | |
|
|
3 | 1 | |||||
| MIRT732128 | BMP7 | bone morphogenetic protein 7 | |
|
2 | 1 | ||||||
| MIRT732466 | EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | |
|
|
3 | 0 | |||||
| MIRT732962 | TNC | tenascin C | |
1 | 0 | |||||||
| MIRT734856 | KDM4A | lysine demethylase 4A | |
|
|
3 | 0 | |||||
| MIRT735625 | MEF2A | myocyte enhancer factor 2A | |
|
2 | 0 | ||||||
| MIRT735795 | IL6 | interleukin 6 | |
|
|
3 | 0 | |||||
| MIRT736333 | DELE1 | KIAA0141 | |
|
2 | 0 | ||||||
| MIRT736610 | RUNX2 | runt related transcription factor 2 | |
|
|
3 | 0 | |||||
| MIRT736830 | NOTCH1 | notch 1 | |
|
|
3 | 0 | |||||
| MIRT736888 | KCNA2 | potassium voltage-gated channel subfamily A member 2 | |
|
|
3 | 0 | |||||
| MIRT737349 | EGFR | epidermal growth factor receptor | |
|
|
3 | 0 | |||||
| MIRT755368 | GLS | glutaminase | 2 | 1 | ||||||||
| MIRT755431 | SPHK2 | sphingosine kinase 2 | 3 | 1 | ||||||||
| MIRT756119 | USP30 | ubiquitin specific peptidase 30 | 4 | 1 | ||||||||
| MIRT756144 | XIAP | X-linked inhibitor of apoptosis | 3 | 1 | ||||||||
| MIRT756170 | COL5A1 | collagen type V alpha 1 chain | 3 | 1 | ||||||||
| MIRT756171 | FSTL1 | follistatin like 1 | 3 | 1 | ||||||||
| miRNA-Drug Associations | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
| miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|