pre-miRNA Information | |
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pre-miRNA | hsa-mir-921 |
Genomic Coordinates | chr1: 166154743 - 166154798 |
Synonyms | MIRN921, hsa-mir-921, MIR921 |
Description | Homo sapiens miR-921 stem-loop |
Comment | None |
RNA Secondary Structure |
Mature miRNA Information | |||||||||||||
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Mature miRNA | hsa-miR-921 | ||||||||||||
Sequence | 2| CUAGUGAGGGACAGAACCAGGAUUC |26 | ||||||||||||
Evidence | Experimental | ||||||||||||
Experiments | Cloned | DRVs in miRNA |
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SNPs in miRNA |
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Putative Targets |
miRNA Expression profile | |
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Human miRNA Tissue Atlas | |
Circulating MicroRNA Expression Profiling |
Gene Information | |||||||||||||||||||||
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Gene Symbol | C16orf52 | ||||||||||||||||||||
Synonyms | - | ||||||||||||||||||||
Description | chromosome 16 open reading frame 52 | ||||||||||||||||||||
Transcript | NM_001164579 | ||||||||||||||||||||
Expression | |||||||||||||||||||||
Putative miRNA Targets on C16orf52 | |||||||||||||||||||||
3'UTR of C16orf52 (miRNA target sites are highlighted) |
>C16orf52|NM_001164579|3'UTR 1 TGAATGTCTAAATTGCTTGACTCTTATTATTTTTTATTTTATTTTATTTTTTTATTTTTGGAGGGTGGAGAGGACAAAGG 81 CGAGGCATCTGAGCAGGCCTCTCATGGGAAGATGCTCAGATGAAACTGATGCTGAGAAGGAAAAAAAAATGCTTTGGTTT 161 GTTCTCACTATGCACTTTGGATTTAAAAAAAAAAAAAAAAAGGAGAGCCTTTTCCATAACCAAATACAGACAATATTGAC 241 TAAATCTCCTGAGCATATTCAGGCAGTCAGGTCTGCACTGTGATAGCAACCTAGAGAAGGAGAATGCTTTATACCGAAAA 321 GCATGTGGCCCTTTGTGACTCTGTTATTCCGTTTTTAATGTCTAATGATTCATTAGAGGAAAAAAAAAAGTCTAAGTATT 401 TATGTGTCATGGTGGACCAGAGGGATGCAAGAGAAGTTCATGTGGGGCTGGCCTCACCTCCTAAGAAATTAGTGTTCACA 481 ACTTCCTTGTAATAGTATGAGCCTTTGGCACCAGAATGGATTGCCGTTGCATTACTGCACCAAGAAGCCAATAGATCAAA 561 ACTTGTTTGCTAAAATGTATGTAAAAATTCTGAAATTCCCTCTCTCTGTGTACAAAAAAAAAAAAAAATCAAACACTAAG 641 ACACATGTTTTGGGTGGGTGGGTGGGGGAAATCTTCCTTATATTTATATAAATATATATAATATATATATTTTGCTGATG 721 CAGTATACAGTGTGTATATATGTGTGTGTGTGTGTGTGTGTATGTGTGTGTAAATTTATATACACACACATGCAAACAGT 801 TCCTGGAAGAGAATTCTGAATGCTTTGCTAGCAAAACACTGTGGTGTGCAAACCTAGAACCCAATAGAAAAAAAAGCCAT 881 TTATCTGAAGGCTGCATAGTGGAGAGAGTCTTCAGTTTACCTCATTCTTTGTAGCAGCCCTTGATTTTAACAGGTTTTTG 961 TAATAGGTACAGATAATCCCATACCTTTCTAGGTGCGATTTTAAGTTAAGCTAAAAATTATTTGTAGGGTTAATTTATTT 1041 GTATATGATAGTAGAAGGTAAGATCATGTCAAACCTTATAATTTGGGGAATCTGACACTATTTAAATTATTGGCAACTGT 1121 TGTCTGTTGTACAGAGATTCTTTTTCTACTGGCTCAGTCTGTTACATTAATAATGCATTTTATATGTTCAGGCACACTTT 1201 ACATAAATACAAAGTTCGCTAGTAAATATCTGGCTATTTTGGCTATTTACAACACTAATTTCATTATTTTTATCTGTAAG 1281 CATTATTAATACATCTTTACCAAAACCTGAGCAATACAATATTTTCTTTATATGTTATATGCCTTTGTTTGCTAAAAGCT 1361 AATATTTTTGCATTTACTTTAAAGGGCTGTACTAAACCCACAGCTTTAAGTTCTTCCCTAAAAGAAGCATTGCAGCTAAC 1441 CCTTGAACTCACAGTTTTAAAATACAGTATTTCTCTTCTCCACATCTCCATGCCTTCGCATCAATGCTTGTTTTTCCTGG 1521 TGAACACTATAGATAATCTCCTGTTTGAAATGTGGGACAGGGTGTTTCATGGCAGTGGAGCTAAGTTTCTCCTCTTTATA 1601 GTGAACTGGTGACCCAAATGTCCCTGTCATTTATAGTGAACTGATGACCCAAATGACTCCCTGTCAGTAGAGTCCCATGT 1681 GGCCCATGCTTCACACAAGCAGAAATGAACGCACTGTTTTTAAGGCTAGATTATCAGTTCTAGAATGATTACTTCAAAGA 1761 TGGGAGCTACCTCCTCAGATATTCACACTATGAAATGGAGGTGCTTGATGTGTTTCACACTGGCTTGTTTGACAGTCTTC 1841 TATCTTACTGTTAATTCAGCAGTATTTTATTGTGAAAGAAAACCCCAGTGTTTGAGCTCACTCAGGAATTGGGGAGAGAG 1921 ATGGACCACCACTGTGGTGCATTTCTTAAGTGTTCTGGGAGAATGTCATACTTTTCCTTCCCAGAGTAAAAGAAACCTTT 2001 GGGAGATCCTGAGGGAGACTGTTTCTCCCCAAGTATGATGATGTCTAGTCAAGTCTAAGAATACCACTGGACATGTTCTA 2081 TGGACATTTGGGATTGCAGTTGCTATTCTGATTTGATTGGTCCTCAGTCAAATGGATCACTTTGAAGGAAAGCTTTGGTT 2161 GTCACCGTTATATACCACTGAGATAAAGTGTTAGCAAAGTATGGTTCAAATTAACTTATGACATGACCAAGAGCTTTTCT 2241 CTTCCAAAAGATGAATTGTATTGTAAATAGTTTCTCAAAATATTTTTAACTGGATCATGAGCATGGGGAGAGAAAGTTTC 2321 TCAGCTGCTAAGAATTTCCCCACTGTTTACTTCTTTCACTTATGGTGGTATTGCATTTAAGATTACAAAATTTAAGGTTT 2401 TATTTGTATCTATTACCCAAACCATTAAATTGTCTTTAATTTCATTGTTGTCTTGGAGGTCCAGTGCATACAGGGCTGAT 2481 GGGGGAAAACTCCCTCTAGCCAGTCAGCACTCTAACCCAGGATTAAACCATCCCATCAAGTAGTATGTGAAGTCAAGTCT 2561 TCGTACTCTTGCAGACCAGACATTGAAATGGATTCATTCATATAGATTTCTATAAATCCTATAAGTGAAAAGATAGACAA 2641 CTGTCCGCAGTTGCTTTTAAAAAAGGTCACTATAATAAGTACTATATAGTACAGTATTAATTTATAGCAGGAAATCGTAT 2721 CTTGTAAACTGTATATAAAACACTGTTTTATGGTGCAATCATTTGTCAAACTTTTGTCTGTTTCATTGTTTTTAGAGTGT 2801 GTGCATTCTTCTCATACCTAAGAATATCACTGTAAAATCTGCTGAAAACTATTTTTAGGTTTTATTTGCACAAGACTGAA 2881 TTAGTTTGACATTTTTGGAAGCTCCTATTGAACATACCCAAACATCTGTAAACATGAAAAATCTTCAATTTATTAAAAGC 2961 AAACATTTCAGTATGATTCTTTCCAAAGGTAATCCATGTTCTATGTTGTTAATGTGTGTATGTAATTTTTCTGACTCTTC 3041 CACCTCTTATAAACCTATTTTCTGTTTCATTTGTTTTGTTTTTGAAGGATGGCTCTTTTTTCTTTTTAATGTTCTAGATG 3121 ACCAAAACACTATTGGTTTTTACCCTTTTGCCTAAAGCTTTGATATCCCCACTTGATGTTCTGTGAATTCACTGTTTAAT 3201 CTATTAAGTGAAATAATAAATAGTCCTGGTGACAAACAATCTGTTGATTTAGAGGAAAGGCCCTGAAAAATACAGTATTG 3281 GAAACTAACTTTGCATATGCTGTTAGCTATTATTTTGCATCATGGGCTTCATGGGAAGAACATGTTGCATTTATTTTGTC 3361 TTTATTAAAAGACTACTAGCCACAAGTTACTCTGATTATAGTAACTGTTTTATCAACCCACTTCATCTTTAAAAAATTAA 3441 ATTTACATTCACAATTCAAAACAGTAAGCTGTCTTTCAGAAAATTTTTGAAGGATAAAAACATGAAGGAAAAAAGTGGCC 3521 CGTGTAGGTAGGATTCCCTACACAGGACTTTTAGTTGTATCACCTCAAGAGATTTTGAAGTTTGTGATCAAGGTCTGTAT 3601 ATTATCCCAAACTTTATTAAGAATTGTTTTCTAATTGGTTATAACATTTTTCAATTAATAGTTTCAAAACAAATTGTTAA 3681 TACAACTGTATAAAATGAACATAATTTTCCTCACTTGTATTTTTGTTATTGAGCAAGTTTATCAAAATAAATTGTCTACT 3761 AAAGAAACTAAAAA Target sites
Provided by authors
Predicted by miRanda
DRVs
SNPs
DRVs & SNPs
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miRNA-target interactions (Predicted by miRanda) |
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DRVs in gene 3'UTRs | |||||||||||||||||||||
SNPs in gene 3'UTRs |
Experimental Support 1 for Functional miRNA-Target Interaction | |||||||
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miRNA:Target | ---- | ||||||
Validation Method |
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Conditions | HEK293 | ||||||
Disease | 730094.0 | ||||||
Location of target site | 3'UTR | ||||||
Tools used in this research | TargetScan , miRTarCLIP , Piranha | ||||||
Original Description (Extracted from the article) |
...
"PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1
... - Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods. |
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miRNA-target interactions (Provided by authors) |
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Article |
- Kishore S; Jaskiewicz L; Burger L; Hausser et al. - Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
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CLIP-seq Support 1 for dataset GSM714644 | |
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Method / RBP | PAR-CLIP / AGO2 |
Cell line / Condition | HEK293 / completeT1, repA |
Location of target site | ENST00000542527.2 | 3UTR | AAAAAAAAAUGCUUUGGUUUGUUCUCACUAUGCACUUUG |
Tools used in this analysis | TargetScan, miRTarCLIP, and Piranha |
Article / Accession Series | PMID: 21572407 / GSE28865 |
CLIP-seq Viewer | Link |
MiRNA-Target Expression Profile | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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MiRNA-Target Expression Profile (TCGA) | |||||||
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63 hsa-miR-921 Target Genes:
Functional analysis:
ID | Target | Description | Validation methods | |||||||||
Strong evidence | Less strong evidence | |||||||||||
MIRT054764 | ANGPTL1 | angiopoietin like 1 | 3 | 1 | ||||||||
MIRT066171 | PIP4K2C | phosphatidylinositol-5-phosphate 4-kinase type 2 gamma | 2 | 2 | ||||||||
MIRT069409 | ZFYVE21 | zinc finger FYVE-type containing 21 | 2 | 8 | ||||||||
MIRT102284 | DNAJB9 | DnaJ heat shock protein family (Hsp40) member B9 | 2 | 4 | ||||||||
MIRT107595 | DNAJA1 | DnaJ heat shock protein family (Hsp40) member A1 | 2 | 6 | ||||||||
MIRT178618 | HIAT1 | major facilitator superfamily domain containing 14A | 2 | 2 | ||||||||
MIRT182407 | TIPRL | TOR signaling pathway regulator | 2 | 4 | ||||||||
MIRT186552 | ZBTB18 | zinc finger and BTB domain containing 18 | 2 | 2 | ||||||||
MIRT273662 | HOXC8 | homeobox C8 | 2 | 2 | ||||||||
MIRT283191 | C16ORF52 | chromosome 16 open reading frame 52 | 2 | 2 | ||||||||
MIRT284890 | NFAT5 | nuclear factor of activated T-cells 5 | 2 | 2 | ||||||||
MIRT347670 | LSM14A | LSM14A, mRNA processing body assembly factor | 2 | 2 | ||||||||
MIRT400222 | SLC35F6 | solute carrier family 35 member F6 | 2 | 2 | ||||||||
MIRT403517 | ASPH | aspartate beta-hydroxylase | 2 | 2 | ||||||||
MIRT442251 | DCTN5 | dynactin subunit 5 | 2 | 2 | ||||||||
MIRT443023 | SDR39U1 | short chain dehydrogenase/reductase family 39U member 1 | 2 | 2 | ||||||||
MIRT443097 | RNF20 | ring finger protein 20 | 2 | 2 | ||||||||
MIRT444560 | TRA2B | transformer 2 beta homolog | 2 | 2 | ||||||||
MIRT445696 | PRKG1 | protein kinase, cGMP-dependent, type I | 2 | 2 | ||||||||
MIRT454084 | TMEM209 | transmembrane protein 209 | 2 | 2 | ||||||||
MIRT455463 | LYPLA2 | lysophospholipase II | 2 | 2 | ||||||||
MIRT456653 | TIFA | TRAF interacting protein with forkhead associated domain | 2 | 2 | ||||||||
MIRT458147 | LYRM4 | LYR motif containing 4 | 2 | 6 | ||||||||
MIRT467073 | SRRD | SRR1 domain containing | 2 | 4 | ||||||||
MIRT467245 | SPPL2A | signal peptide peptidase like 2A | 2 | 2 | ||||||||
MIRT468246 | SFXN4 | sideroflexin 4 | 2 | 2 | ||||||||
MIRT471589 | PAQR5 | progestin and adipoQ receptor family member 5 | 2 | 19 | ||||||||
MIRT476639 | G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | 2 | 2 | ||||||||
MIRT482433 | ADM | adrenomedullin | 2 | 10 | ||||||||
MIRT486848 | PERP | PERP, TP53 apoptosis effector | 2 | 6 | ||||||||
MIRT489656 | SHMT1 | serine hydroxymethyltransferase 1 | 2 | 2 | ||||||||
MIRT493441 | KANSL1 | KAT8 regulatory NSL complex subunit 1 | 2 | 6 | ||||||||
MIRT493841 | FOXN3 | forkhead box N3 | 2 | 4 | ||||||||
MIRT501378 | RBFOX2 | RNA binding protein, fox-1 homolog 2 | 2 | 10 | ||||||||
MIRT509679 | ATAD5 | ATPase family, AAA domain containing 5 | 2 | 4 | ||||||||
MIRT510280 | MED28 | mediator complex subunit 28 | 2 | 2 | ||||||||
MIRT512221 | ATXN3 | ataxin 3 | 2 | 6 | ||||||||
MIRT514030 | BNIP2 | BCL2 interacting protein 2 | 2 | 2 | ||||||||
MIRT521375 | RDX | radixin | 2 | 4 | ||||||||
MIRT521444 | RAD51 | RAD51 recombinase | 2 | 2 | ||||||||
MIRT526055 | CBR1 | carbonyl reductase 1 | 2 | 2 | ||||||||
MIRT528658 | FUNDC2 | FUN14 domain containing 2 | 2 | 2 | ||||||||
MIRT529975 | TNFAIP8L1 | TNF alpha induced protein 8 like 1 | 2 | 2 | ||||||||
MIRT544098 | IPMK | inositol polyphosphate multikinase | 2 | 2 | ||||||||
MIRT545579 | SNRPA1 | small nuclear ribonucleoprotein polypeptide A' | 2 | 2 | ||||||||
MIRT547424 | MED4 | mediator complex subunit 4 | 2 | 2 | ||||||||
MIRT548955 | CD2AP | CD2 associated protein | 2 | 2 | ||||||||
MIRT549537 | NDUFA6 | NADH:ubiquinone oxidoreductase subunit A6 | 2 | 4 | ||||||||
MIRT552550 | ZFP36L2 | ZFP36 ring finger protein like 2 | 2 | 4 | ||||||||
MIRT554640 | ROBO1 | roundabout guidance receptor 1 | 2 | 2 | ||||||||
MIRT564904 | YTHDF1 | YTH N6-methyladenosine RNA binding protein 1 | 2 | 2 | ||||||||
MIRT565578 | SLC6A8 | solute carrier family 6 member 8 | 2 | 2 | ||||||||
MIRT568312 | BAG4 | BCL2 associated athanogene 4 | 2 | 2 | ||||||||
MIRT617891 | PTCHD3 | patched domain containing 3 | 2 | 2 | ||||||||
MIRT621892 | TAF13 | TATA-box binding protein associated factor 13 | 2 | 2 | ||||||||
MIRT642850 | RNF135 | ring finger protein 135 | 2 | 2 | ||||||||
MIRT665395 | WEE1 | WEE1 G2 checkpoint kinase | 2 | 2 | ||||||||
MIRT697879 | UBE2B | ubiquitin conjugating enzyme E2 B | 2 | 2 | ||||||||
MIRT698492 | THOC2 | THO complex 2 | 2 | 2 | ||||||||
MIRT701227 | OCRL | OCRL, inositol polyphosphate-5-phosphatase | 2 | 2 | ||||||||
MIRT701872 | MPLKIP | M-phase specific PLK1 interacting protein | 2 | 2 | ||||||||
MIRT707045 | TRPV2 | transient receptor potential cation channel subfamily V member 2 | 2 | 2 | ||||||||
MIRT715216 | NPVF | neuropeptide VF precursor | 2 | 2 |
miRNA-Drug Associations | |||||||||||||||||||||||||||
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miRNA-Drug Resistance Associations | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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