miRTarBase - #MIRT284426


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pre-miRNA Information
pre-miRNA hsa-mir-4270   
Genomic Coordinates chr3: 15496239 - 15496308
Description Homo sapiens miR-4270 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4270
Sequence 11| UCAGGGAGUCAGGGGAGGGC |30
Evidence Experimental
Experiments SOLiD
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs991570490 2 dbSNP
rs1417709982 10 dbSNP
rs960511282 12 dbSNP
rs928808979 14 dbSNP
rs1372156971 15 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol CAPN15   
Synonyms SOLH
Description calpain 15
Transcript NM_005632   
Expression
Putative miRNA Targets on CAPN15
3'UTR of CAPN15
(miRNA target sites are highlighted)		 
>CAPN15|NM_005632|3'UTR
   1 CCACCATGCCTGGGGCAGGGGCTGTGCACAGACGGACCCCCCACCCCCACACGCACTTTATGAGGGAGACCCCGACAGAG
  81 GACGCTTGAGCCAGAATCTCAGGACCCCGCCCAGGGAGCTGCCAGCCCAGGGCTCAGCTTCCCATGGGCCCCCCGCCCCC
 161 CTCCTTCCCCTCCCTGAACCCCACAGTCCGCCTGGCCAGGCCTCCTGGCCGCCACGCAGAATACCTCGAACCAGGCGGGC
 241 TGTGAACCAGCCCCGCTCACCTGCCAGCCCCAACACCCGACGGGGGCCGAGGCCAGGCTGCCCCTCCCTGTGGGCTCAGG
 321 GTCTCCTGCGGGCTAGGCAGCCAGGAGCTCTGTCCGCAAAACCAAATCTGGGTGTCAGAGGCCAAGACCCTGGGGTGGGA
 401 TCAGGGACCACCCCTCACGGGGCATAAGGTCAGTTTTCCCCCAGAGCCCGGGTCCCTGTCCCCCACAGGGCAGGCGGGGT
 481 CCCTGGAGCCCTGGTGTGGAGCGGCGAGTCCCGGGGCGGTGCCTGTCTCAGAAGAAGGGGCCCTTGGCCAGCCCCCCAGC
 561 GACACTATGCAAATCCTGGAGTGCCCGCCAGGATCGAAGCCATGACTGGGTGCAGGCGGGCGCCAGGCCCGCTGTGGGTG
 641 GGCACCAGTTCTCAGCACCGCTCACTGCTGCCGGGCACACTGGGACCAGCAGGCTCCTCAGCCAACCCTGTCCCTCGGCC
 721 CGGCCCTGCCAGAGAGGGACCCCAGCACATCGTGGGCACGGGCAGGGCTCAGCCGCTCCCACCTCCCCACAGAAGCCCAG
 801 GAGTGTGTGGACGTCTGAGCCCAGCTTTCTGCGTGCCCTCCTGGCCCCTCACTCCCGGCAGCGGGCCGGCCTCGCCCCCA
 881 CTCCCCCTCCTACCCCGGCAGGGGCTTCCGGGGCCTTTTCACCTGGAGAAACATTCCCACTCCCCTTTGGCCTCCCTGTA
 961 CTCTGAGCTGTGAATATTTTTAACCCTGTAAATACGGCCAGCTCTTGTGACACAGAGACTATTTTATCAATTGTCAGTCC
1041 CGTTCCTTTACCATAGGATTCTCCACAGTGGCTTCCGACTCAGGCTCCAATGGACCAAATAAAAGCGTTTTGTTTTGTAA
1121 AAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cggGAGGGGA---CUGAGGGACu 5'
             |||||||   | ||||||| 
Target 5' ccaCTCCCCTTTGGCCTCCCTGt 3'
 937 - 959 165.00 -27.60
2 
miRNA  3' cgGGAGGGGACUGAGGGACu 5'
            |||:|||   ||||||| 
Target 5' ctCCTTCCC---CTCCCTGa 3'
 161 - 177 159.00 -26.40
3 
miRNA  3' cggGAGGGGACUGAGGGACu 5'
             || |||   ||||||| 
Target 5' aggCTGCCC---CTCCCTGt 3'
 295 - 311 150.00 -19.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN28847342 2 COSMIC
COSN30522697 17 COSMIC
COSN13680312 35 COSMIC
COSN25751050 44 COSMIC
COSN13680313 54 COSMIC
COSN30172617 101 COSMIC
COSN20078681 237 COSMIC
COSN20078466 283 COSMIC
COSN20157752 419 COSMIC
COSN14485186 552 COSMIC
COSN7263405 631 COSMIC
COSN18723413 718 COSMIC
COSN31607677 833 COSMIC
COSN26669524 910 COSMIC
COSN30543147 943 COSMIC
COSN30542686 944 COSMIC
COSN30172496 964 COSMIC
COSN26668975 1032 COSMIC
COSN24385290 1043 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1462650548 4 dbSNP
rs756171466 9 dbSNP
rs780128717 10 dbSNP
rs1247824213 11 dbSNP
rs1389187959 21 dbSNP
rs754309501 22 dbSNP
rs755612564 25 dbSNP
rs375077512 26 dbSNP
rs1291875102 27 dbSNP
rs748560105 34 dbSNP
rs370085862 35 dbSNP
rs1250973543 36 dbSNP
rs752786979 37 dbSNP
rs766236853 37 dbSNP
rs373297984 38 dbSNP
rs561192987 39 dbSNP
rs770351925 40 dbSNP
rs1427020258 41 dbSNP
rs776271287 43 dbSNP
rs1383739676 44 dbSNP
rs759032666 45 dbSNP
rs115215017 47 dbSNP
rs775377549 49 dbSNP
rs1188154302 50 dbSNP
rs762768865 53 dbSNP
rs1264764794 54 dbSNP
rs1269942421 71 dbSNP
rs115624718 72 dbSNP
rs1186473093 73 dbSNP
rs571447267 74 dbSNP
rs538872095 75 dbSNP
rs1352663974 80 dbSNP
rs1165900459 81 dbSNP
rs1378955267 82 dbSNP
rs1277275849 83 dbSNP
rs1227303804 84 dbSNP
rs1051757217 85 dbSNP
rs910643632 86 dbSNP
rs1159299110 93 dbSNP
rs1323258218 100 dbSNP
rs1401802934 109 dbSNP
rs943481124 110 dbSNP
rs371593856 114 dbSNP
rs1037703434 119 dbSNP
rs1472343976 132 dbSNP
rs899183299 133 dbSNP
rs1341297418 143 dbSNP
rs565686396 144 dbSNP
rs1216166075 147 dbSNP
rs1282146165 149 dbSNP
rs1449904347 149 dbSNP
rs375085852 155 dbSNP
rs1221335561 156 dbSNP
rs1352867348 156 dbSNP
rs1240836832 157 dbSNP
rs1048022936 161 dbSNP
rs1003718627 162 dbSNP
rs1342187095 163 dbSNP
rs1199394624 166 dbSNP
rs1035407350 171 dbSNP
rs1256375610 172 dbSNP
rs1443811882 182 dbSNP
rs958474437 183 dbSNP
rs536198295 190 dbSNP
rs538999660 191 dbSNP
rs1187322651 195 dbSNP
rs1476291516 203 dbSNP
rs1240121447 204 dbSNP
rs1021274147 205 dbSNP
rs773001066 206 dbSNP
rs1463220640 211 dbSNP
rs1439621532 212 dbSNP
rs968819939 216 dbSNP
rs865979282 217 dbSNP
rs554279489 219 dbSNP
rs369156969 227 dbSNP
rs746599849 228 dbSNP
rs924532467 229 dbSNP
rs1435053853 233 dbSNP
rs770585968 237 dbSNP
rs182123844 238 dbSNP
rs910413677 240 dbSNP
rs943446507 245 dbSNP
rs1038218554 253 dbSNP
rs920576042 254 dbSNP
rs929317632 255 dbSNP
rs150894987 256 dbSNP
rs1244957329 257 dbSNP
rs1329006675 261 dbSNP
rs1375961132 264 dbSNP
rs1232935795 268 dbSNP
rs906793638 269 dbSNP
rs1447263157 276 dbSNP
rs373318833 279 dbSNP
rs376775446 280 dbSNP
rs1228201825 282 dbSNP
rs868168911 283 dbSNP
rs1317819691 286 dbSNP
rs895328054 287 dbSNP
rs1346651548 289 dbSNP
rs369514128 290 dbSNP
rs1368883804 293 dbSNP
rs1021806934 296 dbSNP
rs1425142014 301 dbSNP
rs1386827023 302 dbSNP
rs1162656111 309 dbSNP
rs1423126830 315 dbSNP
rs904148907 326 dbSNP
rs1178366527 330 dbSNP
rs998483725 331 dbSNP
rs1031333083 334 dbSNP
rs954623164 337 dbSNP
rs1198220748 339 dbSNP
rs1294336314 340 dbSNP
rs1017423010 347 dbSNP
rs1321571896 348 dbSNP
rs1378320871 351 dbSNP
rs1348707091 354 dbSNP
rs373663897 356 dbSNP
rs556472699 357 dbSNP
rs920681090 358 dbSNP
rs929260008 363 dbSNP
rs983446222 364 dbSNP
rs11539618 369 dbSNP
rs939565510 375 dbSNP
rs1055815377 378 dbSNP
rs895289026 389 dbSNP
rs879395604 394 dbSNP
rs1042777565 396 dbSNP
rs1269918103 398 dbSNP
rs371405763 404 dbSNP
rs1488350828 410 dbSNP
rs1261895974 411 dbSNP
rs1388462997 412 dbSNP
rs1211094212 415 dbSNP
rs775423217 419 dbSNP
rs1287752976 420 dbSNP
rs545242676 430 dbSNP
rs1447200836 436 dbSNP
rs1031277493 440 dbSNP
rs1386066259 446 dbSNP
rs1301361655 450 dbSNP
rs890146852 450 dbSNP
rs553800278 451 dbSNP
rs116919151 454 dbSNP
rs542971308 455 dbSNP
rs1387314621 456 dbSNP
rs1216265093 459 dbSNP
rs1277099995 460 dbSNP
rs561145019 462 dbSNP
rs1199607300 464 dbSNP
rs1197721898 465 dbSNP
rs1433010701 473 dbSNP
rs1191080719 476 dbSNP
rs562644577 476 dbSNP
rs973654682 477 dbSNP
rs1027524812 483 dbSNP
rs1204325025 492 dbSNP
rs139421036 495 dbSNP
rs1209835694 496 dbSNP
rs983559166 498 dbSNP
rs927938338 499 dbSNP
rs543726554 503 dbSNP
rs565223049 504 dbSNP
rs116442579 506 dbSNP
rs1044282012 507 dbSNP
rs1399395426 511 dbSNP
rs547617233 513 dbSNP
rs924135226 514 dbSNP
rs934396060 518 dbSNP
rs565728236 519 dbSNP
rs1248018195 524 dbSNP
rs1184751720 530 dbSNP
rs1444244180 537 dbSNP
rs767627522 544 dbSNP
rs1008983881 546 dbSNP
rs1293977289 554 dbSNP
rs796350987 561 dbSNP
rs1397541293 562 dbSNP
rs900412115 565 dbSNP
rs994805963 568 dbSNP
rs1216001893 578 dbSNP
rs529769000 581 dbSNP
rs1332888206 584 dbSNP
rs1027882632 587 dbSNP
rs548142077 588 dbSNP
rs1305787130 593 dbSNP
rs1004943555 597 dbSNP
rs1035122947 603 dbSNP
rs375928519 607 dbSNP
rs1366799382 613 dbSNP
rs960662010 614 dbSNP
rs991218994 615 dbSNP
rs185934244 618 dbSNP
rs536687907 619 dbSNP
rs968686013 622 dbSNP
rs56163833 623 dbSNP
rs571610115 625 dbSNP
rs538805775 631 dbSNP
rs924081140 632 dbSNP
rs1239213554 637 dbSNP
rs935518414 638 dbSNP
rs1286118813 639 dbSNP
rs1408784683 652 dbSNP
rs1370363958 659 dbSNP
rs1052763072 661 dbSNP
rs1422954540 662 dbSNP
rs1389279637 664 dbSNP
rs554085300 669 dbSNP
rs1163182351 671 dbSNP
rs1165253678 672 dbSNP
rs911651996 673 dbSNP
rs572473704 674 dbSNP
rs1180321384 675 dbSNP
rs1472365271 677 dbSNP
rs1417836564 678 dbSNP
rs1157494796 679 dbSNP
rs1449644890 680 dbSNP
rs1360682687 688 dbSNP
rs1205619029 689 dbSNP
rs542730714 690 dbSNP
rs1285859386 693 dbSNP
rs1227401230 700 dbSNP
rs1345681500 716 dbSNP
rs1300655327 717 dbSNP
rs1378031939 718 dbSNP
rs1329679975 721 dbSNP
rs1323536853 722 dbSNP
rs1395758798 723 dbSNP
rs1390966174 731 dbSNP
rs1156952118 737 dbSNP
rs1456929342 740 dbSNP
rs1039110234 741 dbSNP
rs900189103 746 dbSNP
rs1476944208 752 dbSNP
rs555082788 753 dbSNP
rs1466143901 757 dbSNP
rs1049022762 760 dbSNP
rs576352032 761 dbSNP
rs1004722793 763 dbSNP
rs1317536676 764 dbSNP
rs1034883465 767 dbSNP
rs11539619 768 dbSNP
rs1012354305 773 dbSNP
rs372323100 775 dbSNP
rs549739470 776 dbSNP
rs924197305 779 dbSNP
rs780342821 781 dbSNP
rs956837512 783 dbSNP
rs567936697 784 dbSNP
rs1178571952 786 dbSNP
rs1412939871 787 dbSNP
rs912770595 789 dbSNP
rs944436087 790 dbSNP
rs1187815023 794 dbSNP
rs921569307 795 dbSNP
rs930346215 798 dbSNP
rs1048970792 799 dbSNP
rs35673689 801 dbSNP
rs541194411 804 dbSNP
rs886346582 805 dbSNP
rs940625353 807 dbSNP
rs1056289767 812 dbSNP
rs1401899277 813 dbSNP
rs896346697 814 dbSNP
rs1380014909 820 dbSNP
rs1358195767 822 dbSNP
rs1446105343 827 dbSNP
rs1466270072 829 dbSNP
rs1012717843 830 dbSNP
rs559306885 834 dbSNP
rs903812081 841 dbSNP
rs1167907109 843 dbSNP
rs1424283795 846 dbSNP
rs1309090030 848 dbSNP
rs1179551199 852 dbSNP
rs1482636889 854 dbSNP
rs1374730327 855 dbSNP
rs1000828690 857 dbSNP
rs1030995986 858 dbSNP
rs529932606 860 dbSNP
rs1205075707 861 dbSNP
rs987036978 863 dbSNP
rs1019727534 864 dbSNP
rs780416723 868 dbSNP
rs974876861 869 dbSNP
rs1197784851 870 dbSNP
rs768798658 874 dbSNP
rs779236502 875 dbSNP
rs547967079 876 dbSNP
rs1188918992 878 dbSNP
rs1351606891 879 dbSNP
rs369875335 881 dbSNP
rs1162596498 882 dbSNP
rs1433397812 883 dbSNP
rs1422773554 885 dbSNP
rs569779560 886 dbSNP
rs1397683481 887 dbSNP
rs1464359182 888 dbSNP
rs1250077080 895 dbSNP
rs1331129015 897 dbSNP
rs530377756 898 dbSNP
rs940572998 902 dbSNP
rs1056406421 910 dbSNP
rs755404759 911 dbSNP
rs15312 929 dbSNP
rs1268808995 934 dbSNP
rs896285075 937 dbSNP
rs375985418 944 dbSNP
rs142713286 945 dbSNP
rs1369428269 949 dbSNP
rs35424156 954 dbSNP
rs1045520974 955 dbSNP
rs1388777909 957 dbSNP
rs868502860 959 dbSNP
rs1455171888 964 dbSNP
rs1367070384 965 dbSNP
rs1199090038 972 dbSNP
rs1434166710 973 dbSNP
rs1269851096 976 dbSNP
rs903929903 980 dbSNP
rs1224219928 982 dbSNP
rs879876467 985 dbSNP
rs1316319947 986 dbSNP
rs1460017618 994 dbSNP
rs1169182732 996 dbSNP
rs746689558 997 dbSNP
rs1434590495 998 dbSNP
rs1210734117 999 dbSNP
rs1030943019 1002 dbSNP
rs773324793 1003 dbSNP
rs1234211506 1005 dbSNP
rs1415796186 1005 dbSNP
rs892496751 1009 dbSNP
rs1295122574 1010 dbSNP
rs1324946504 1015 dbSNP
rs760888267 1016 dbSNP
rs1270799646 1018 dbSNP
rs766509561 1022 dbSNP
rs754010610 1027 dbSNP
rs1383131902 1029 dbSNP
rs1278125324 1030 dbSNP
rs770675872 1031 dbSNP
rs1200886899 1032 dbSNP
rs1260566612 1033 dbSNP
rs1426416164 1034 dbSNP
rs538966571 1036 dbSNP
rs756174071 1039 dbSNP
rs7763 1039 dbSNP
rs1194905953 1040 dbSNP
rs975617081 1042 dbSNP
rs1453272488 1043 dbSNP
rs1172253227 1045 dbSNP
rs1377868348 1046 dbSNP
rs1435692722 1051 dbSNP
rs571772482 1052 dbSNP
rs1383289780 1054 dbSNP
rs1384100343 1055 dbSNP
rs1463643320 1056 dbSNP
rs1261056733 1058 dbSNP
rs1333976311 1059 dbSNP
rs1319236633 1062 dbSNP
rs1201248084 1064 dbSNP
rs1378078927 1065 dbSNP
rs1370268188 1066 dbSNP
rs1232261236 1073 dbSNP
rs1301149154 1077 dbSNP
rs753202452 1078 dbSNP
rs771068501 1080 dbSNP
rs1348166699 1085 dbSNP
rs1233672780 1088 dbSNP
rs1259876198 1091 dbSNP
rs1226011110 1094 dbSNP
rs538757790 1102 dbSNP
rs951755986 1107 dbSNP
rs984565752 1108 dbSNP
rs1305085638 1117 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions C8166
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462572. RNA binding protein: AGO2. Condition:C8166 NL4-3 ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgggaggGGACUGA--GGGAcu 5'
                 || |:||  ||||  
Target 5' ------gCCAGGCUGCCCCUcc 3'
 		1 - 16
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462572
Method / RBP PAR-CLIP / AGO2
Cell line / Condition C8166 / C8166 NL4-3
Location of target site ENST00000219611.2 | 3UTR | GCCAGGCUGCCCCUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
146 hsa-miR-4270 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT056076 PIP4K2A phosphatidylinositol-5-phosphate 4-kinase type 2 alpha 2 2
MIRT057833 SLC30A7 solute carrier family 30 member 7 2 2
MIRT109295 TXLNG taxilin gamma 2 2
MIRT117521 MIDN midnolin 2 2
MIRT183504 BTG2 BTG anti-proliferation factor 2 2 2
MIRT258346 HOXA11 homeobox A11 2 6
MIRT275743 TFDP1 transcription factor Dp-1 2 2
MIRT284426 CAPN15 calpain 15 2 2
MIRT386430 CCL22 C-C motif chemokine ligand 22 2 2
MIRT443374 PLXNA2 plexin A2 2 2
MIRT445251 SEMA5A semaphorin 5A 2 2
MIRT445767 CCND3 cyclin D3 2 2
MIRT447231 ABI2 abl interactor 2 2 2
MIRT451224 ZNF444 zinc finger protein 444 2 2
MIRT451433 TJP3 tight junction protein 3 2 4
MIRT451959 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT452006 FKBP5 FK506 binding protein 5 2 2
MIRT452300 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT452717 DTHD1 death domain containing 1 2 2
MIRT453361 ZNF3 zinc finger protein 3 2 2
MIRT453458 GLG1 golgi glycoprotein 1 2 2
MIRT453832 SAA1 serum amyloid A1 2 2
MIRT453928 COMMD5 COMM domain containing 5 2 4
MIRT454312 ZNF134 zinc finger protein 134 2 2
MIRT454493 SLC29A1 solute carrier family 29 member 1 (Augustine blood group) 2 2
MIRT454836 POLR2J3 RNA polymerase II subunit J3 2 2
MIRT455142 TBC1D25 TBC1 domain family member 25 2 2
MIRT455922 RAPGEF1 Rap guanine nucleotide exchange factor 1 2 2
MIRT456163 TTF2 transcription termination factor 2 2 2
MIRT456395 KLHL12 kelch like family member 12 2 2
MIRT456786 MTHFSD methenyltetrahydrofolate synthetase domain containing 2 2
MIRT457164 MXRA7 matrix remodeling associated 7 2 2
MIRT457190 ERC1 ELKS/RAB6-interacting/CAST family member 1 2 2
MIRT457415 RPL36 ribosomal protein L36 2 2
MIRT457630 UPK3BL uroplakin 3B like 1 2 2
MIRT458720 VPS39 VPS39, HOPS complex subunit 2 2
MIRT458745 CES2 carboxylesterase 2 2 2
MIRT459269 ADRBK1 G protein-coupled receptor kinase 2 2 2
MIRT459490 CCL11 C-C motif chemokine ligand 11 2 2
MIRT460319 SH3RF1 SH3 domain containing ring finger 1 2 2
MIRT461005 SYT7 synaptotagmin 7 2 2
MIRT461579 SCO1 SCO1, cytochrome c oxidase assembly protein 2 4
MIRT461820 SNAP23 synaptosome associated protein 23 2 2
MIRT463332 ZFHX3 zinc finger homeobox 3 2 2
MIRT463449 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT464272 VCL vinculin 2 2
MIRT464895 UBALD1 UBA like domain containing 1 2 2
MIRT465556 TOB2 transducer of ERBB2, 2 2 2
MIRT466360 THBS1 thrombospondin 1 2 2
MIRT466956 STAT3 signal transducer and activator of transcription 3 2 2
MIRT467321 SPATA2 spermatogenesis associated 2 2 2
MIRT467440 SND1 staphylococcal nuclease and tudor domain containing 1 2 2
MIRT467823 SLC29A2 solute carrier family 29 member 2 2 2
MIRT471173 PHB2 prohibitin 2 2 2
MIRT471397 PDPR pyruvate dehydrogenase phosphatase regulatory subunit 2 2
MIRT471754 OGT O-linked N-acetylglucosamine (GlcNAc) transferase 2 2
MIRT471846 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT472020 NPTXR neuronal pentraxin receptor 2 2
MIRT472224 NGFR nerve growth factor receptor 2 2
MIRT472439 NBL1 neuroblastoma 1, DAN family BMP antagonist 2 2
MIRT472541 NACC1 nucleus accumbens associated 1 2 2
MIRT473195 MINOS1-NBL1 MINOS1-NBL1 readthrough 2 2
MIRT473211 MINK1 misshapen like kinase 1 2 2
MIRT473668 MARCKSL1 MARCKS like 1 2 2
MIRT474852 KHSRP KH-type splicing regulatory protein 2 2
MIRT474939 KCTD15 potassium channel tetramerization domain containing 15 2 2
MIRT477330 EPHA2 EPH receptor A2 2 2
MIRT477395 ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2 2
MIRT477466 ELMSAN1 ELM2 and Myb/SANT domain containing 1 2 2
MIRT477974 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT478331 DDN dendrin 2 2
MIRT479481 CDK2 cyclin dependent kinase 2 2 2
MIRT481212 ATXN7L3B ataxin 7 like 3B 2 2
MIRT481263 ATXN7L3 ataxin 7 like 3 2 2
MIRT481409 ASXL1 additional sex combs like 1, transcriptional regulator 2 2
MIRT482051 AMD1 adenosylmethionine decarboxylase 1 2 2
MIRT482396 AEN apoptosis enhancing nuclease 2 2
MIRT483160 PCSK2 proprotein convertase subtilisin/kexin type 2 2 7
MIRT483370 CYP4A22 cytochrome P450 family 4 subfamily A member 22 2 2
MIRT483520 QRSL1 glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 2 4
MIRT484059 CYP4A11 cytochrome P450 family 4 subfamily A member 11 2 2
MIRT487075 CLASP1 cytoplasmic linker associated protein 1 2 4
MIRT487421 CACNB1 calcium voltage-gated channel auxiliary subunit beta 1 2 2
MIRT488359 PAX2 paired box 2 2 2
MIRT488592 ST7L suppression of tumorigenicity 7 like 2 2
MIRT489556 SOX11 SRY-box 11 2 4
MIRT489804 KRT80 keratin 80 2 4
MIRT489865 ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 2 2
MIRT490014 KIFC2 kinesin family member C2 2 2
MIRT490036 PCSK4 proprotein convertase subtilisin/kexin type 4 2 2
MIRT491070 ACVR1B activin A receptor type 1B 2 2
MIRT494016 DUSP9 dual specificity phosphatase 9 2 2
MIRT494816 AKAP11 A-kinase anchoring protein 11 2 2
MIRT495991 LTBP2 latent transforming growth factor beta binding protein 2 2 2
MIRT496272 SLC2A13 solute carrier family 2 member 13 2 2
MIRT500454 ZFP36L1 ZFP36 ring finger protein like 1 2 2
MIRT507989 BCL2L13 BCL2 like 13 2 4
MIRT509713 ANKRD23 ankyrin repeat domain 23 2 2
MIRT527984 TSLP thymic stromal lymphopoietin 2 2
MIRT530448 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT531235 FANCC Fanconi anemia complementation group C 2 2
MIRT534590 RPL28 ribosomal protein L28 2 2
MIRT535990 MED28 mediator complex subunit 28 2 4
MIRT537280 GABRA5 gamma-aminobutyric acid type A receptor alpha5 subunit 2 2
MIRT539924 DUSP28 dual specificity phosphatase 28 2 2
MIRT554711 RNF146 ring finger protein 146 2 2
MIRT558962 CAMSAP2 calmodulin regulated spectrin associated protein family member 2 2 2
MIRT568497 ARHGDIA Rho GDP dissociation inhibitor alpha 2 2
MIRT568875 LY6H lymphocyte antigen 6 family member H 2 2
MIRT568987 CACNA1C calcium voltage-gated channel subunit alpha1 C 2 2
MIRT569990 TMEM184A transmembrane protein 184A 2 2
MIRT570485 THRA thyroid hormone receptor, alpha 2 2
MIRT572826 MYO1C myosin IC 2 2
MIRT608199 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT613220 CCDC85C coiled-coil domain containing 85C 2 4
MIRT629782 PTDSS2 phosphatidylserine synthase 2 2 2
MIRT635332 RASSF4 Ras association domain family member 4 2 2
MIRT653632 SLC30A3 solute carrier family 30 member 3 2 2
MIRT664572 GUF1 GUF1 homolog, GTPase 2 2
MIRT667855 IPCEF1 interaction protein for cytohesin exchange factors 1 2 2
MIRT668820 CYLD CYLD lysine 63 deubiquitinase 2 2
MIRT671274 ETFDH electron transfer flavoprotein dehydrogenase 2 2
MIRT681448 CIITA class II major histocompatibility complex transactivator 2 2
MIRT684817 BRIX1 BRX1, biogenesis of ribosomes 2 2
MIRT685861 ANGEL1 angel homolog 1 2 2
MIRT688812 CAPZB capping actin protein of muscle Z-line beta subunit 2 2
MIRT691198 NIF3L1 NGG1 interacting factor 3 like 1 2 2
MIRT696947 CERK ceramide kinase 2 2
MIRT699741 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT701259 NUP35 nucleoporin 35 2 2
MIRT701935 MLLT1 MLLT1, super elongation complex subunit 2 2
MIRT703332 GDPD5 glycerophosphodiester phosphodiesterase domain containing 5 2 2
MIRT705519 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 2 2
MIRT706065 PKD1 polycystin 1, transient receptor potential channel interacting 2 2
MIRT713238 SV2B synaptic vesicle glycoprotein 2B 2 2
MIRT714670 CHRNE cholinergic receptor nicotinic epsilon subunit 2 2
MIRT715001 TSPAN11 tetraspanin 11 2 2
MIRT715356 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT715971 FADS3 fatty acid desaturase 3 2 2
MIRT719585 FNBP4 formin binding protein 4 2 2
MIRT719667 DMRT2 doublesex and mab-3 related transcription factor 2 2 2
MIRT723360 ASCL2 achaete-scute family bHLH transcription factor 2 2 2
MIRT734985 GADD45A growth arrest and DNA damage inducible alpha 2 0
MIRT735022 MMP19 matrix metallopeptidase 19 3 0
MIRT737359 SATB2 SATB homeobox 2 3 0
MIRT756223 MCM3 minichromosome maintenance complex component 3 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-4270 Ginsenoside Rh2 NULL 119307 Microarray NSCLC cell line A549 23152132 2013 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4270 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-4270 Fulvestrant 17756771 NSC719276 approved sensitive High Breast Cancer cell line (MCF-7)
hsa-miR-4270 Cisplatin 5460033 NSC119875 approved resistant High Hypopharyngeal Cancer cell line (FaDu)
hsa-mir-4270 Cisplatin 5460033 NSC119875 approved resistant cell line (BxPC3)
hsa-miR-4270 Cisplatin 5460033 NSC119875 approved resistant cell line (CAL-27) (cytosolic RNA)
hsa-miR-4270 Cisplatin 5460033 NSC119875 approved sensitive cell line (CAL-27) (total RNA)
hsa-miR-4270 Cisplatin 5460033 NSC119875 approved resistant cell line (CP20)
hsa-miR-4270 Cisplatin 5460033 NSC119875 approved resistant cell line (CIS)
hsa-miR-4270 Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-4270 Gemcitabine 60750 NSC613327 approved resistant cell line (MDA-231)
hsa-miR-4270 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-4270 Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM16)
hsa-miR-4270 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-4270 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4270 Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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