miRTarBase - #MIRT296659


—
pre-miRNA Information
pre-miRNA hsa-mir-4720   
Genomic Coordinates chr16: 81385018 - 81385093
Description Homo sapiens miR-4720 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4720-5p
Sequence 4| CCUGGCAUAUUUGGUAUAACUU |25
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs750386566 4 dbSNP
rs532921899 5 dbSNP
rs1025678089 6 dbSNP
rs1435476609 11 dbSNP
rs1426449829 13 dbSNP
rs1349517705 17 dbSNP
rs1448030025 20 dbSNP
Putative Targets

Gene Information
Gene Symbol MRGBP   
Synonyms C20orf20, Eaf7, MRG15BP, URCC4
Description MRG domain binding protein
Transcript NM_018270   
Expression
Putative miRNA Targets on MRGBP
3'UTR of MRGBP
(miRNA target sites are highlighted)		 
>MRGBP|NM_018270|3'UTR
   1 ACCCTCAGCCCTGGTGGCGGCAGAGAAGCGGGCGAGGCACTGTGGTCGCTGAGGGGGTTGGCTGGGTCTGAGTGCCACCC
  81 CCCAGGCCACAGTGATACCATCCCAGTGCCATGAGCCCACACTGCCCGCCCTCAGGCTCTCAGGTGAACGTGGCCGTCAG
 161 CGGGGAAACGTGTGTGTCAGTTGGACCATGTGGGACCCTGATGGACCTGAAAGACCAGGATCGGTCCAGCTCAGATATTG
 241 AGGGCTCTGAAGCCTAGTTCTGTCTTCTCTGGAGCAGCTGTGGCTTCCCCGTGGCTGCTTGGTGACATGGATTAGCGCTA
 321 CGTGGGCTGCAGCATTTGGGATCCAGGCTACCTAGAGGGGCATCGGGCCAGGGAAAACCTCGGATTAGCAAGCAATAAAA
 401 ACATGACCTCACTCTTCCTCAAAGGAGCCCCTGGTCTTCCCTGTGTGACTCAGTTCTTTCCATCTGTTTGTCCCGCTGCA
 481 AGCCTCTTTCTGCGCTGACTGTGACATTGGAACGTGGCCTTCCTGTCACCCCCTCCGTGCCACGCACTGAAGGCCACCCC
 561 CACCCACCTGGGAAACTAAGAACTGGATATTTTGCCTCATTCACTTGTACTGTAACAATGTATATAATTTGGTTGGTATT
 641 TCACTATTTAATTTTTAAGAAGCCTATTTTACTAGTGTTTTATATGAACAAAGTACTGCAGAAGTTAAACCTGTGTTGTA
 721 TTTTTTCTGAGATGTTTTGCTTTAAGAGATACTTTTTGCTCAGTTTTTATATGCCAGATACAGAGAATTTGTAGCGGTTA
 801 TTTTTGTATGATCTAGTAACTTGCAAACAGACCAAATGGATGAGAGGCGGGGACCGTGCAGCTGTCGGCTGATGAGGAGG
 881 CGGCCGCCCCAGTGCTGATGGAGATGCCACTTTCGTGTGACTGCGAACATTAAAGCACAAAAAAATCCAACCTGGAGTTG
 961 TGTGATTTTGATACCAAAGTAAGTTCACTTTTCCTCCAAAAGGAAGTTTTTATTTTTCCAAGATTTATAACTAAAGCATA
1041 CACTTAGATGACTTATTAACATTCACTTGATACAACATATAAACAAAATAGTAACAGATTCTGAGTGGTTATTTTGTGGA
1121 CTGTGACAAGCACTTCAAATACAAAATGTTAGGAGGGCAAAACGGTGCGGGCCCTCGTAGGTCAGGCAGGCACCAGTGGG
1201 CTCCTTCCTGCTGAAAGCTGCGGCTGTGAGATGAGACCGCTGGCTGGGTCACAGAGTGAAATCCAGCGTTCCGTGTGCGG
1281 ACGAGGAGACAAGCTGTCCTGGCCAGCCATCGCACCCCAATGTCTTCAGCTTGACGTTGCTTCTCTGCCAGTGGAGCCTC
1361 CTCCACCACCTGGGAACATCCCTGGCCATCTGTCCCTGAAGTCCTCCTCACCATGACGCAGATCACAAGGCACCCACTAA
1441 AGGGGCAAAGCCAGGAATCCCGTGCCATGTGATCGCCCCGTGTGGCACCTGCCACTCGTCTGCACCAAACGCACTGCCAG
1521 TTCTGGGGAAGAACAGCCCAGGGAAGCTGCTGGTCTACGGCCTGCCTGAGCTGTATTCCAAGGGTAGAGCAGCTGCCTGG
1601 GGGGACCCTGTGGGTCCCTTTTCTATAGAGCCGGGACAAATCCACAGCCCTGCAGTAACAGCCTGCCACAAAGAGCAGGC
1681 ATCTGGAGGGCCCCACACACATAGACCAAAGGACTGAGCCCGCCTGGCATTCCTCCACTCACAGCACAAATACTCAGCCC
1761 TGCAGCCAGGGAAGGGTGGGGTCTCCCTTTGCTGCCCAAGTGTGCCCCCTTGCCCGTCTGATCTCTCCTGTTAGGTCAGC
1841 CTCATTCAGGGCTTTGTGCCAGGTCCTGTCCTGGAGTCTCAGTCCGGGACAGCAGCCTGGCTCTTAGGCAGTCCAGAAGC
1921 AGCAGGGCAAAGGGGGGCAAATACTAACACGGGGTGTCACGGGATGGCCAGGAGGAGTCCTGCTCGCCACCCAGGCTCAC
2001 TGTCCTAAACCTCCATCTGAAACCGCATCTCGGGTGACCTCAGATTGTGCTAGGAAAGCCTAGTTAATAAATCTGCCTCA
2081 TCTCGATTACTGTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uucAAUAUG-GUU-----UAUACGGUCc 5'
             || |:| ||:     ||||||||| 
Target 5' actTTTTGCTCAGTTTTTATATGCCAGa 3'
 751 - 778 155.00 -11.90
2 
miRNA  3' uuCAAUAUGGUUUAUACGGUcc 5'
            ||  |: :::| ||||||  
Target 5' caGTGCTGATGGAGATGCCAct 3'
 890 - 911 132.00 -8.10
3 
miRNA  3' uucAAUAUGGUUU----AUACGGUCc 5'
             | || :||::    |:|||||| 
Target 5' gccTCAT-TCAGGGCTTTGTGCCAGg 3'
 1839 - 1863 132.00 -16.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30519533 7 COSMIC
COSN26984993 28 COSMIC
COSN18716837 31 COSMIC
COSN30516889 82 COSMIC
COSN26984994 84 COSMIC
COSN30487331 118 COSMIC
COSN22245763 193 COSMIC
COSN20093794 511 COSMIC
COSN31531420 562 COSMIC
COSN31519262 630 COSMIC
COSN32014764 669 COSMIC
COSN31518622 778 COSMIC
COSN30164279 797 COSMIC
COSN31482680 826 COSMIC
COSN30541063 827 COSMIC
COSN15632596 1204 COSMIC
COSN6688357 1222 COSMIC
COSN28884832 1269 COSMIC
COSN20906120 1674 COSMIC
COSN17052690 1743 COSMIC
COSN9147154 1772 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs375969763 2 dbSNP
rs1299545107 4 dbSNP
rs773565903 5 dbSNP
rs762503821 7 dbSNP
rs115713234 8 dbSNP
rs1399486639 11 dbSNP
rs903860521 12 dbSNP
rs1313142922 13 dbSNP
rs1182142208 14 dbSNP
rs372413684 19 dbSNP
rs200313208 20 dbSNP
rs890941951 21 dbSNP
rs866293168 28 dbSNP
rs1278026550 29 dbSNP
rs1308591695 30 dbSNP
rs752591959 31 dbSNP
rs1254305222 33 dbSNP
rs41279362 34 dbSNP
rs374650982 35 dbSNP
rs1293408072 40 dbSNP
rs753804259 48 dbSNP
rs370543250 49 dbSNP
rs1309681191 56 dbSNP
rs1444338020 58 dbSNP
rs1333862284 60 dbSNP
rs1195111814 64 dbSNP
rs1270800239 70 dbSNP
rs974404204 78 dbSNP
rs1392968791 79 dbSNP
rs894721886 84 dbSNP
rs1443868261 88 dbSNP
rs1424238162 90 dbSNP
rs1381361586 97 dbSNP
rs970165535 105 dbSNP
rs1469072212 116 dbSNP
rs1363669698 117 dbSNP
rs1210625551 123 dbSNP
rs1451742062 124 dbSNP
rs1013203146 128 dbSNP
rs1258480839 129 dbSNP
rs1485490829 131 dbSNP
rs1490074372 137 dbSNP
rs1185869752 141 dbSNP
rs1045106341 146 dbSNP
rs1225205085 147 dbSNP
rs979828526 149 dbSNP
rs1425818488 150 dbSNP
rs906216104 151 dbSNP
rs543112417 156 dbSNP
rs561187774 157 dbSNP
rs1347522099 161 dbSNP
rs956700730 161 dbSNP
rs938426454 162 dbSNP
rs1418066150 163 dbSNP
rs1404601784 167 dbSNP
rs116883192 169 dbSNP
rs772897902 170 dbSNP
rs1374456753 172 dbSNP
rs760594787 173 dbSNP
rs945617658 179 dbSNP
rs1022114938 189 dbSNP
rs539166236 190 dbSNP
rs953279385 194 dbSNP
rs771060065 195 dbSNP
rs1196594566 198 dbSNP
rs1268330770 199 dbSNP
rs1263376101 203 dbSNP
rs932669136 217 dbSNP
rs1445128219 223 dbSNP
rs986030794 224 dbSNP
rs1219555881 234 dbSNP
rs1279402038 242 dbSNP
rs1484586092 244 dbSNP
rs375207438 245 dbSNP
rs1222918630 247 dbSNP
rs1265630047 250 dbSNP
rs966077787 253 dbSNP
rs11554807 257 dbSNP
rs1192653109 258 dbSNP
rs919345209 263 dbSNP
rs930748914 265 dbSNP
rs1404475879 268 dbSNP
rs759165295 270 dbSNP
rs571088405 271 dbSNP
rs532307785 272 dbSNP
rs1419598194 285 dbSNP
rs547367728 291 dbSNP
rs906154520 292 dbSNP
rs1187941992 310 dbSNP
rs142144651 312 dbSNP
rs775167046 315 dbSNP
rs535830667 317 dbSNP
rs554664843 318 dbSNP
rs1381156072 322 dbSNP
rs572514765 323 dbSNP
rs1332735702 330 dbSNP
rs569739887 353 dbSNP
rs888964265 359 dbSNP
rs1361478005 365 dbSNP
rs537118265 366 dbSNP
rs1454857064 375 dbSNP
rs1381035899 381 dbSNP
rs561928718 382 dbSNP
rs1466584267 383 dbSNP
rs1242129529 391 dbSNP
rs1171854783 399 dbSNP
rs1018864729 404 dbSNP
rs1407884725 409 dbSNP
rs966393908 411 dbSNP
rs578208674 415 dbSNP
rs75924758 416 dbSNP
rs952090479 425 dbSNP
rs984890565 426 dbSNP
rs750752811 430 dbSNP
rs1182963344 432 dbSNP
rs1458131473 437 dbSNP
rs1202464187 441 dbSNP
rs948869793 441 dbSNP
rs1307146541 443 dbSNP
rs925555619 445 dbSNP
rs982057862 454 dbSNP
rs1453427654 457 dbSNP
rs554124522 462 dbSNP
rs748971060 475 dbSNP
rs139779958 476 dbSNP
rs1448209262 484 dbSNP
rs1376105758 487 dbSNP
rs1452945901 491 dbSNP
rs1052090563 494 dbSNP
rs1426140088 495 dbSNP
rs530882709 495 dbSNP
rs541432443 495 dbSNP
rs542624192 499 dbSNP
rs1037116552 507 dbSNP
rs7396 509 dbSNP
rs1480383643 512 dbSNP
rs1269673814 514 dbSNP
rs542319924 515 dbSNP
rs1452664853 518 dbSNP
rs995774113 523 dbSNP
rs1156468057 530 dbSNP
rs188689185 533 dbSNP
rs56005449 537 dbSNP
rs1007388852 538 dbSNP
rs1372043961 544 dbSNP
rs150726996 545 dbSNP
rs901745952 547 dbSNP
rs1406421459 557 dbSNP
rs993844704 559 dbSNP
rs1035321365 562 dbSNP
rs7397 563 dbSNP
rs1156900791 564 dbSNP
rs1009989590 566 dbSNP
rs952038118 577 dbSNP
rs1020478841 579 dbSNP
rs1479586952 584 dbSNP
rs374212134 588 dbSNP
rs1268368878 591 dbSNP
rs1205940303 595 dbSNP
rs1334974809 596 dbSNP
rs984834719 597 dbSNP
rs1023053410 603 dbSNP
rs1215755604 605 dbSNP
rs970165318 608 dbSNP
rs981621952 613 dbSNP
rs1224749630 617 dbSNP
rs1343255999 619 dbSNP
rs181179214 620 dbSNP
rs3833338 621 dbSNP
rs1363868033 625 dbSNP
rs1286864223 640 dbSNP
rs1406654538 645 dbSNP
rs1452993432 645 dbSNP
rs139052179 647 dbSNP
rs1273099809 653 dbSNP
rs748345828 664 dbSNP
rs758556357 665 dbSNP
rs1467555709 667 dbSNP
rs1194225477 675 dbSNP
rs1430489572 676 dbSNP
rs529714756 685 dbSNP
rs777620478 689 dbSNP
rs946386608 691 dbSNP
rs149896401 696 dbSNP
rs1265468745 697 dbSNP
rs912558029 699 dbSNP
rs569650227 700 dbSNP
rs1320865330 707 dbSNP
rs910293028 711 dbSNP
rs1251627817 714 dbSNP
rs41279364 715 dbSNP
rs1179154769 716 dbSNP
rs1390579539 719 dbSNP
rs1293193287 721 dbSNP
rs558681281 721 dbSNP
rs1381376986 722 dbSNP
rs1383253433 724 dbSNP
rs901690860 728 dbSNP
rs144952634 747 dbSNP
rs538817958 755 dbSNP
rs1405489246 756 dbSNP
rs1168526880 770 dbSNP
rs554466544 782 dbSNP
rs918637320 783 dbSNP
rs931431688 784 dbSNP
rs1170191408 786 dbSNP
rs770968480 789 dbSNP
rs566963116 796 dbSNP
rs1298714480 797 dbSNP
rs887733413 808 dbSNP
rs1461232717 815 dbSNP
rs776749659 817 dbSNP
rs1023001201 824 dbSNP
rs1342556341 825 dbSNP
rs543283600 835 dbSNP
rs554578505 841 dbSNP
rs1249328456 849 dbSNP
rs1292798203 849 dbSNP
rs148652471 850 dbSNP
rs1243724157 851 dbSNP
rs1009937106 856 dbSNP
rs1019963698 857 dbSNP
rs1480503929 866 dbSNP
rs868607637 867 dbSNP
rs769379404 868 dbSNP
rs1035837374 869 dbSNP
rs1425507070 874 dbSNP
rs999955106 875 dbSNP
rs543558684 879 dbSNP
rs774873366 882 dbSNP
rs989036464 883 dbSNP
rs762597608 886 dbSNP
rs1184595781 887 dbSNP
rs190972715 889 dbSNP
rs564636946 893 dbSNP
rs985659575 894 dbSNP
rs1490399607 903 dbSNP
rs1019852852 906 dbSNP
rs535258186 911 dbSNP
rs1355559321 914 dbSNP
rs973119877 915 dbSNP
rs1241080077 916 dbSNP
rs111671968 918 dbSNP
rs931356739 925 dbSNP
rs979052606 926 dbSNP
rs1424503401 932 dbSNP
rs564995505 936 dbSNP
rs1386117998 939 dbSNP
rs927109351 939 dbSNP
rs1160855224 956 dbSNP
rs144461918 961 dbSNP
rs1361590939 964 dbSNP
rs1180765570 973 dbSNP
rs1304411379 980 dbSNP
rs1377478720 984 dbSNP
rs1270501241 988 dbSNP
rs763716692 989 dbSNP
rs1057061665 997 dbSNP
rs1415572571 998 dbSNP
rs1312530532 999 dbSNP
rs377621095 1007 dbSNP
rs895708492 1020 dbSNP
rs747490951 1034 dbSNP
rs910240331 1037 dbSNP
rs8117374 1038 dbSNP
rs1224132694 1039 dbSNP
rs1296916335 1040 dbSNP
rs1347465439 1043 dbSNP
rs1307467188 1045 dbSNP
rs559477525 1048 dbSNP
rs773609611 1049 dbSNP
rs1258087241 1053 dbSNP
rs761072542 1057 dbSNP
rs1349092881 1062 dbSNP
rs41308098 1065 dbSNP
rs1254982063 1072 dbSNP
rs1488979066 1076 dbSNP
rs6062691 1081 dbSNP
rs563317275 1082 dbSNP
rs1477469958 1085 dbSNP
rs1260923258 1093 dbSNP
rs1242514756 1094 dbSNP
rs1194995598 1096 dbSNP
rs755489732 1098 dbSNP
rs1044396328 1104 dbSNP
rs530468687 1106 dbSNP
rs905873650 1109 dbSNP
rs1325817564 1111 dbSNP
rs1261304441 1119 dbSNP
rs1178170476 1120 dbSNP
rs1002928406 1122 dbSNP
rs1006984117 1124 dbSNP
rs1428981523 1126 dbSNP
rs1364913285 1135 dbSNP
rs1433874127 1138 dbSNP
rs1036188786 1143 dbSNP
rs552313155 1146 dbSNP
rs1407707572 1151 dbSNP
rs1173284370 1152 dbSNP
rs956187095 1158 dbSNP
rs1419707082 1164 dbSNP
rs1373945433 1165 dbSNP
rs1432937345 1166 dbSNP
rs867732335 1168 dbSNP
rs570530453 1169 dbSNP
rs973019037 1169 dbSNP
rs1021776025 1170 dbSNP
rs147845986 1175 dbSNP
rs765296140 1177 dbSNP
rs1209433044 1178 dbSNP
rs1380981414 1182 dbSNP
rs1438610644 1188 dbSNP
rs1275458310 1189 dbSNP
rs375342041 1191 dbSNP
rs964739881 1193 dbSNP
rs1341956976 1194 dbSNP
rs6122299 1197 dbSNP
rs1060961 1204 dbSNP
rs1248834157 1221 dbSNP
rs6011392 1222 dbSNP
rs1300573165 1226 dbSNP
rs958792634 1239 dbSNP
rs777904699 1242 dbSNP
rs929099335 1249 dbSNP
rs1354603621 1254 dbSNP
rs6122300 1267 dbSNP
rs1330536417 1268 dbSNP
rs1427393321 1269 dbSNP
rs1277749524 1271 dbSNP
rs1446381458 1272 dbSNP
rs983265611 1273 dbSNP
rs909065802 1274 dbSNP
rs370509381 1279 dbSNP
rs1294388094 1280 dbSNP
rs941899383 1281 dbSNP
rs554840284 1283 dbSNP
rs1484625583 1284 dbSNP
rs905827037 1296 dbSNP
rs1192783576 1297 dbSNP
rs1253562072 1300 dbSNP
rs945944892 1303 dbSNP
rs938677373 1313 dbSNP
rs1303535416 1315 dbSNP
rs1191555984 1321 dbSNP
rs1426384136 1322 dbSNP
rs1393476142 1324 dbSNP
rs1164057308 1325 dbSNP
rs1402615613 1330 dbSNP
rs1419568206 1332 dbSNP
rs1057164168 1336 dbSNP
rs891860815 1337 dbSNP
rs1010298064 1341 dbSNP
rs1050064077 1352 dbSNP
rs1451732435 1359 dbSNP
rs888841508 1360 dbSNP
rs1487740357 1362 dbSNP
rs1265198333 1364 dbSNP
rs746769284 1376 dbSNP
rs1217176100 1380 dbSNP
rs1395944572 1386 dbSNP
rs757075820 1397 dbSNP
rs1225967488 1401 dbSNP
rs1301763272 1404 dbSNP
rs1283587523 1412 dbSNP
rs904712089 1414 dbSNP
rs1041163774 1418 dbSNP
rs576032443 1419 dbSNP
rs1292689539 1420 dbSNP
rs1223957257 1423 dbSNP
rs901385253 1427 dbSNP
rs41298350 1432 dbSNP
rs1430050644 1437 dbSNP
rs570298171 1440 dbSNP
rs965691752 1442 dbSNP
rs1005524593 1444 dbSNP
rs1034370843 1447 dbSNP
rs1187415607 1457 dbSNP
rs1487138672 1459 dbSNP
rs1246795290 1462 dbSNP
rs976141086 1463 dbSNP
rs1224998851 1468 dbSNP
rs1468015612 1475 dbSNP
rs1030022858 1476 dbSNP
rs950424586 1478 dbSNP
rs1363800628 1480 dbSNP
rs558647228 1481 dbSNP
rs1262882111 1486 dbSNP
rs985209774 1488 dbSNP
rs909013562 1489 dbSNP
rs1177936000 1490 dbSNP
rs1464747092 1493 dbSNP
rs935934372 1496 dbSNP
rs941848431 1498 dbSNP
rs1430720347 1499 dbSNP
rs1388678907 1501 dbSNP
rs1417403606 1504 dbSNP
rs944453073 1511 dbSNP
rs539227693 1512 dbSNP
rs1167244820 1514 dbSNP
rs1481987815 1516 dbSNP
rs1255113814 1519 dbSNP
rs980000983 1520 dbSNP
rs1040139414 1521 dbSNP
rs1344095192 1524 dbSNP
rs901319575 1528 dbSNP
rs927192168 1528 dbSNP
rs938639396 1529 dbSNP
rs1338789809 1532 dbSNP
rs1394430580 1533 dbSNP
rs994375355 1540 dbSNP
rs1057436705 1553 dbSNP
rs762639796 1556 dbSNP
rs946105451 1558 dbSNP
rs41310195 1560 dbSNP
rs1443404577 1563 dbSNP
rs1297238553 1569 dbSNP
rs1387554891 1570 dbSNP
rs1005811928 1576 dbSNP
rs1370777469 1580 dbSNP
rs1254832593 1584 dbSNP
rs1196052048 1586 dbSNP
rs541496829 1594 dbSNP
rs904660821 1596 dbSNP
rs1293313294 1598 dbSNP
rs767775241 1599 dbSNP
rs1333558060 1600 dbSNP
rs559323446 1605 dbSNP
rs1339983467 1607 dbSNP
rs1007010299 1609 dbSNP
rs773881924 1611 dbSNP
rs967879041 1611 dbSNP
rs1307812589 1614 dbSNP
rs1425753226 1615 dbSNP
rs574569516 1618 dbSNP
rs1275039717 1632 dbSNP
rs769620727 1633 dbSNP
rs1018473611 1634 dbSNP
rs901404484 1636 dbSNP
rs572573726 1644 dbSNP
rs986045464 1649 dbSNP
rs542146425 1651 dbSNP
rs535077082 1653 dbSNP
rs1030382485 1654 dbSNP
rs944400483 1655 dbSNP
rs1479810709 1656 dbSNP
rs1291715997 1669 dbSNP
rs1208018200 1674 dbSNP
rs1355492772 1676 dbSNP
rs975791892 1694 dbSNP
rs1230231756 1696 dbSNP
rs1348703298 1698 dbSNP
rs530537704 1701 dbSNP
rs929069198 1701 dbSNP
rs1474924615 1702 dbSNP
rs1321938117 1703 dbSNP
rs983161929 1704 dbSNP
rs1016020444 1706 dbSNP
rs554679481 1715 dbSNP
rs888621776 1719 dbSNP
rs1410849935 1722 dbSNP
rs963156044 1723 dbSNP
rs1170248503 1725 dbSNP
rs941589183 1728 dbSNP
rs1443927324 1729 dbSNP
rs6090117 1734 dbSNP
rs564091082 1736 dbSNP
rs1313114106 1740 dbSNP
rs41302952 1743 dbSNP
rs546665864 1746 dbSNP
rs1262421864 1747 dbSNP
rs1412443804 1748 dbSNP
rs1014232989 1752 dbSNP
rs1327213917 1753 dbSNP
rs1267541218 1756 dbSNP
rs1224378676 1758 dbSNP
rs1340040605 1763 dbSNP
rs1273453037 1769 dbSNP
rs992770397 1773 dbSNP
rs1327379424 1788 dbSNP
rs773957456 1791 dbSNP
rs764008216 1795 dbSNP
rs1024745699 1803 dbSNP
rs1433485575 1803 dbSNP
rs1385838662 1814 dbSNP
rs946053094 1816 dbSNP
rs999351920 1817 dbSNP
rs375380598 1823 dbSNP
rs926026737 1827 dbSNP
rs78693896 1828 dbSNP
rs1258504773 1831 dbSNP
rs1373401445 1835 dbSNP
rs1040253638 1840 dbSNP
rs548485994 1841 dbSNP
rs1190471127 1845 dbSNP
rs569986491 1851 dbSNP
rs1185596858 1855 dbSNP
rs1204314970 1864 dbSNP
rs1444197895 1865 dbSNP
rs998811999 1869 dbSNP
rs1017503705 1870 dbSNP
rs965948713 1871 dbSNP
rs1226862990 1881 dbSNP
rs1047314771 1886 dbSNP
rs73317069 1887 dbSNP
rs1167875606 1888 dbSNP
rs1360375123 1890 dbSNP
rs1331838693 1892 dbSNP
rs1417728804 1894 dbSNP
rs1004546073 1904 dbSNP
rs929038621 1905 dbSNP
rs1015964047 1906 dbSNP
rs1389554745 1918 dbSNP
rs1184120592 1921 dbSNP
rs562785139 1931 dbSNP
rs1235773658 1933 dbSNP
rs1209716387 1934 dbSNP
rs558562830 1936 dbSNP
rs117333166 1937 dbSNP
rs1319780249 1938 dbSNP
rs1293216088 1945 dbSNP
rs1055984398 1949 dbSNP
rs116182384 1951 dbSNP
rs993114156 1961 dbSNP
rs760032331 1962 dbSNP
rs1309473620 1967 dbSNP
rs73317070 1969 dbSNP
rs1372837983 1981 dbSNP
rs1234825046 1986 dbSNP
rs967300359 1987 dbSNP
rs1281303180 1991 dbSNP
rs1347490597 1994 dbSNP
rs1181291788 1996 dbSNP
rs1473043312 2000 dbSNP
rs903216685 2003 dbSNP
rs1180271207 2008 dbSNP
rs750589861 2014 dbSNP
rs1482961326 2015 dbSNP
rs752800721 2016 dbSNP
rs1224458100 2023 dbSNP
rs1198971218 2025 dbSNP
rs1287140745 2030 dbSNP
rs574553701 2032 dbSNP
rs892959459 2033 dbSNP
rs1007319542 2034 dbSNP
rs1407585406 2035 dbSNP
rs368413400 2037 dbSNP
rs1293844239 2046 dbSNP
rs1438537255 2050 dbSNP
rs1347976847 2051 dbSNP
rs1017412386 2054 dbSNP
rs965898048 2061 dbSNP
rs1193323975 2064 dbSNP
rs1246785479 2068 dbSNP
rs1455848756 2069 dbSNP
rs997851793 2070 dbSNP
rs542013522 2072 dbSNP
rs918520985 2078 dbSNP
rs1452135957 2079 dbSNP
rs762981386 2085 dbSNP
rs557316546 2086 dbSNP
rs1209888160 2087 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uucaauaugguuUAUACGGUCc 5'
                      ||||||||| 
Target 5' -------uuuuuAUAUGCCAGa 3'
 		1 - 15
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 55257.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uucaauaugguuUAUACGGUCc 5'
                      ||||||||| 
Target 5' -------uuuuuAUAUGCCAGa 3'
 		1 - 15
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 55257.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065669. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000370487.3 | 3UTR | UUUUUAUAUGCCAGAUACAGAGAAUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000370487.3 | 3UTR | UUUUUAUAUGCCAGAUACAGAGAAUUUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1065669
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_8
Location of target site ENST00000370487.3 | 3UTR | UUUUUAUAUGCCAGAUACAGAGAAUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
40 hsa-miR-4720-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT064869 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT099937 SOX4 SRY-box 4 2 2
MIRT204534 SLC39A10 solute carrier family 39 member 10 2 4
MIRT221679 ZNRF2 zinc and ring finger 2 2 2
MIRT296659 MRGBP MRG domain binding protein 2 6
MIRT331634 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT337078 RER1 retention in endoplasmic reticulum sorting receptor 1 2 2
MIRT497580 PTCHD4 patched domain containing 4 2 2
MIRT498838 NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 2 4
MIRT502561 EBAG9 estrogen receptor binding site associated, antigen, 9 2 2
MIRT508128 AMD1 adenosylmethionine decarboxylase 1 2 2
MIRT511875 GOLGA7 golgin A7 2 6
MIRT512924 UBL4A ubiquitin like 4A 2 2
MIRT513833 KLHL15 kelch like family member 15 2 6
MIRT515889 FAM182B family with sequence similarity 182 member B 2 2
MIRT520201 WASL Wiskott-Aldrich syndrome like 2 2
MIRT526045 GMDS GDP-mannose 4,6-dehydratase 2 2
MIRT533601 TNPO1 transportin 1 2 2
MIRT535539 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 6
MIRT541150 PABPC1 poly(A) binding protein cytoplasmic 1 2 4
MIRT549609 TMEM101 transmembrane protein 101 2 2
MIRT552630 ZBTB41 zinc finger and BTB domain containing 41 2 2
MIRT555503 PNISR PNN interacting serine and arginine rich protein 2 2
MIRT560225 PCNA proliferating cell nuclear antigen 2 2
MIRT561671 RAPGEF2 Rap guanine nucleotide exchange factor 2 2 2
MIRT562103 ITGB1 integrin subunit beta 1 2 2
MIRT570710 E2F3 E2F transcription factor 3 2 2
MIRT570802 CKAP2L cytoskeleton associated protein 2 like 2 2
MIRT615261 DPF2 double PHD fingers 2 2 2
MIRT615389 ZNF747 zinc finger protein 747 2 2
MIRT616621 KCNJ11 potassium voltage-gated channel subfamily J member 11 2 4
MIRT641085 ZKSCAN2 zinc finger with KRAB and SCAN domains 2 2 2
MIRT654971 PLEKHA2 pleckstrin homology domain containing A2 2 2
MIRT667033 PDE3A phosphodiesterase 3A 2 2
MIRT677217 RASSF6 Ras association domain family member 6 2 2
MIRT699243 SLC6A8 solute carrier family 6 member 8 2 2
MIRT711673 TRMT5 tRNA methyltransferase 5 2 2
MIRT713922 CACNA2D1 calcium voltage-gated channel auxiliary subunit alpha2delta 1 2 2
MIRT722736 BRMS1 breast cancer metastasis suppressor 1 2 2
MIRT724997 CDC27 cell division cycle 27 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4720-5p Gefitinib 123631 NSC715055 approved sensitive High Non-Small Cell Lung Cancer cell line (PC-9)
hsa-miR-4720-5p Yuanhuadine 6440572 sensitive High Non-Small Cell Lung Cancer cell line (PC-9)
hsa-miR-4720-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4720-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-4720-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-4720-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-4720-5p Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-4720-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)

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