miRTarBase - #MIRT300900


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pre-miRNA Information
pre-miRNA hsa-mir-3915   
Genomic Coordinates chrX: 32583656 - 32583752
Description Homo sapiens miR-3915 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3915
Sequence 21| UUGAGGAAAAGAUGGUCUUAUU |42
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs997323565 10 dbSNP
rs1192161547 15 dbSNP
rs1255075246 19 dbSNP
rs1452812574 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol KREMEN1   
Synonyms ECTD13, KREMEN, KRM1
Description kringle containing transmembrane protein 1
Transcript NM_001039570   
Other Transcripts NM_032045   
Expression
Putative miRNA Targets on KREMEN1
3'UTR of KREMEN1
(miRNA target sites are highlighted)		 
>KREMEN1|NM_001039570|3'UTR
   1 AAACCCCACTGTGCCTAGGACTTGAGGTCCCTCTTTGAGCTCAAGGCTGCCGTGGTCAACCTCTCCTGTGGTTCTTCTCT
  81 GACAGACTCTTCCCCTCCTCTCCCTCTGCCTCGGCCTCTTCGGGGAAACCCTCCTCCTACAGACTAGGAAGAGGCACCCT
 161 GCTGCCAGGGCAGGCAGAGCCTGGATTCCTCCTGCTTCATCGATTGCACTTAGGAGAGAGACTCAAAGCCCTGGGGCCCG
 241 GCCCTCTCTGCATCTCTCTCTGATCTAGCTAGCAGTGGGGGTGTCAGGACAGTGAGGCTGAGATGACAGAGGTGGTCATG
 321 GCTGGCACAGGGCTCAGGTACATTCTAGATGGCTGTCAGGTGGTGGGTAGCTTTAGTTACATTGAATTTTTCTTGCTTCT
 401 CTATTTTTGTCCACACACAAATCAGTTTCTCCTGATCTTTATGTCTTGGAACAGGGCCAGACAGGGAGAACTCTCAGGTA
 481 CTCTTGGGAGTTGGTCCCATACAAGTGCGGACTCCTGGACATTAGCGAGGTGTAAAGAGGGCAGTGTCTGTGCTGCCCCG
 561 GCAGCTTTGCTCTCCAGATGCTGGACTAGGGTGGGCCTCCTTCAGCCTGGGAGGGTCTGAGAATAAGATCTAGTGACCCC
 641 CATTTATATCAAACCTGATACCTTACACATGGGCTTCTTTCTAGATTCTTCTTTCCATAGCTCATGGAGCTGCAGGGAAA
 721 GCTTTAAGAGCTTTGGTCATATAAAACATCCATTCAGCTGGGCGCGATGGCTCATGCCTGTAATCCCAGCACTGTGGGAG
 801 GCTGAGGCGGGCAGATCACCTGAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTGAAACCCCGTCTCTACTAAAAA
 881 TATAAAAATTAGTCAGGCGTGGTGGCAGGCGCCTGTAATCCCAGCTACTCAGAAGGCTGAGACAGAAGAACAGCTTGAAC
 961 CCAGGAGGCTGAGATTGCAGTGAGCCGAGATCGCACCACTGCACTCCAGCCTGGGTGACAAGAGTGAGACTCTGTCTCAA
1041 AAAAACAAAACACAAATAAACAAAAAAAATCCATTCATTTACTCATGCAATAAATTCTCCTGCAAGCTTTTATGGGCACT
1121 CAGTAAGTACTCAGGATTGGCTTTATCAGCCTTGCCACTGAGCAGCTCATGGTCCTATGGAACCTGAGCCAGGCCTCAGT
1201 CTCTCCATGATTGGCTCAGCTAACTCTCAGTTCAGAGTGGAGAGTATCAATCTTGTGTTTTTGCCCTTAGGCAGCACTAT
1281 ATGAGACATGGGGCCTGTGGTCCTTCCTTCTGGTGTCCCCCGTGTTAAAAGATAAAAAACACCCCAAGGGCCGGGCGCGG
1361 TGGCTCATGCCTGTAATCCCAGCACTTTGGGAGGCTGAGGCGGGTGGATCACGAGGTCAGGTGATCGAAACCATCCTGGC
1441 TAAGATGGTGAAACCCCGTCTCTACTAAAAATACAAAAAATTAGCTGGGTGTGGTGGTGGGCGCCTGTAGTCCCAGCTGC
1521 TCGGGAGGCTGAGGCAGGAGAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCAGAGATCACGCCACTGCACTCCA
1601 GCCTGGGTGACAGTGCAAGACTCTGTCTCAAAAAAAAAAAAAACACTCCAAGGGCCATCCGTGCTCTCTGCCCCTCCTGT
1681 GGGGACCAAGTGGGGTTAGGAATGGCTCAGTGGGGAAGGAGAGCACTCTTGTCCCCAGTCCCTTGCCACCCTGTCCCTTA
1761 GATAGGGAGGTGGGCTGCAGAGATTGGTGCCAGAAGAGGGTGGGTTTGGGAATTGGAGCTCCTCCAAGGAGCTCCTCCTA
1841 AGATTGAGTGCTGCAGCTGTAGTGGCTGCTGGTTGGGAGAGTAAGTGCCATCACTAATTTAAAAGTCCTTGCCATCTGGA
1921 ATCAGGCTTTGTCAACAGCAGCTGAGAAAAGCAGCCTGTGCCTCTGCTGGCCAGGCCTAGGCCCTCGTCAGAGCGTGCCT
2001 CTCCACAAGGCACTTGGGCCTGGGTGATTGTTGCGCCTCTGGCTTTGGCGTTTCCTCTTTGCAGCACTTTGCCTACCTCC
2081 CCCAAGCCCTGAGCCACTGCCTGCTGGGGCTCCTACTGAGGTTCTGGAAACACCTCTGCACCTGCCGCCCCTGGGAGGAA
2161 AGAGGGCCACACAGGAAGTGTCTGCAGGGAGAGGTGGCACTCGGCAGCCTGAGTTCAGGAGAGGTGCTTGGAGCTTCAGG
2241 CAGAGGGGCCTTCAGAGGAGGGAAACGGAGCAATGTGTCACAGGCAGGCAGGGGCAGGACTGCCACCCCAGGCCCCGTGG
2321 GAGGCCTGCTGAGGGCACAGAGCTGCTCGGTGCAGCCTTCATGCTTTGATCTGGAAAGAGCAGCTGTCCGCAGGCCTCTG
2401 TCTCCAAGAGGCCTGTCACACAGGAGGACCGCTGGAAACATACCAACACGTGCAGTCTCCCCTCCAAGCTATTCATGCTG
2481 TTTGTGGAATCTCTCTCAAACATAAGTGTCAGGTGTGTGTCGTCCCAACGGGTCCTGTGCTGTGAATAGATCCATGTGCA
2561 GCACAAAGGGAATGTGGCACGTGGCCCCAGGAAGAGTTCACCCGGCCAGGGGGCAGTTGTTCAGTTGCCTGGGGCTGACA
2641 CTGACCACTGGCCTCTGGGGTGTCCTGCAGCCCAAATGCCCACCTTGCCCTCCTCACATCTCAGTCAGGGGAGGCCATGC
2721 CCAAGCCAATGTGCTGTCACAGCCTGCAGCGGGGGCAGCACTTCCTCGGAGGGCCTGGGAGGTGCTGGGGATGCCCCAGC
2801 GCTTCTCTTCCTGCCTCGCCCTGGCATGGCCCAGCGCCTCTAGGATCAACTTACGATCCGTGGAGCAGCCCCGGGAAACC
2881 CAAATCTGGCTCAGGACAGCGTACGGGCAGGAGGGCTGTAAATCATCCCAGGCTAAGCCTCCGTGGGCACTGGCTCCTGC
2961 CGCAGCCTGGCTATGGACTCAGTTAGAACCAGGTAGAAAGTCAGCGACACCCCACAGAAGGCCACTGCGGCTAGGTAAAC
3041 ACCTGAGAAAGAAACTGCTCCAGAAGAGATGACGTGGGCTTCCAGGAGCATGGAGGAGGTGGCACTTGAACTTTTAGGAA
3121 ACTCCTTAGATGAGATAAAGTGGGGGTTGGAGGTGGCGAAAAGAGGGTAACCCTGGGAAAGTCAGTCAGAACCCATGGCA
3201 GAAGACTGCAGGAGAGGCAGGGGAGGGGCTTCGGGGACCACTGTGGACAGAGCTCTGAAAGCACCCTGGCCAAAGCCCCT
3281 CCTGAGGTGACAGAGCGTGGGAGGAGGCTGCACTGGGCCTGCGTGCCATCCTCACCCCTGTTCCCCGCTGGCGCCAGGCC
3361 CTGCCTTCTTGGTACCTGTGCCAACAGGAGAGCCCTCACCAGCCGATCTTGTCACTCTCCGTGGTGACAGTGTCTTGGCC
3441 AGCTGTGGCCCCTAGTTTCTAGCAGCGTTTCTCAGTGTCCTTGGCCCTTCTGAGAAGGCAGGCGGGAGGCACACGGTGCC
3521 CTGTTCTTCCCCGTTTGTCCAGTTGCTTGCAAAGCAGAGAATGAGTAGGAGTGAACCCGAGTGACTTCACCCGCCCTGTC
3601 CCCCACGTCAGGACAGGCTTGAGGCCTCTCTGGGCGTGAGCGAGGAAACCAGGCTGCTCTAACTTCTGAAGAGTGGGCTC
3681 TGGCTCAAGACTCCAATCGGCCAGAAGCCCACAGAGATCAAAGCACTAGCAAGTTCAGCTGTCCTGGCCCTCGGGTAGAA
3761 CCCACGGGCGTGCCTGGGTGCGGCTCCACCCACATGCCCCACTGTCAGCCCAGGCAGGAGCCTTCCTGGCCGGGCTCAGG
3841 ATCTGCCTGCAGCCCAGCCAGGCCATCACCCAGCCCCGATGCATCCTGGCACTGCACGCTTACTCTTCACAAGCACTTAT
3921 ACGCGGATGGCCTCCGAGACCCTGCCTCCCTGGTCTGCTGAGGTCAGGCCAGGTCTCCCACGGAGCCGGGCAGCTCCACA
4001 CCCCACCACCTGGCACCGTTAGGTTTCAGATCTCCCGTGTGGTGTTTGATGTCGGCTTTTGTTCCTACCTTGGGAGTTTG
4081 GATTGTTTCCTCTGGTGTCTTTGTTTACCTTCCTCACTGTTCTACCTCCTGGCCAGGTCTCAGCTTAGCTTCCCTGGTGT
4161 GGGGTGTTTTTCAAGCCTTCCAGCCACAGCTGTCTCCCCTCAGGCTGGACGGCTCCGGGGTGACAGGGCTTCACCCTCTG
4241 CCTGCAGACCCCTGGTGGGCACATCTCACAGGCTTCCGTCTTGCTGAGTTGGGTACGGAGGCAGAAGTGGGGTGTGGAGG
4321 AAAGTCAGAGGGAAATCTGCTTCAGAAAGGAAGGGTCTTTAGACACAAAGACTGGAGGCCCTTCCCCGCCCGCACGGGAG
4401 CTGCCATCGTGGGTCTCATGCACGTCAAGACCTTCCCACATCCAAACTCAGCTTCCAGCAGGGATTTTGACTTTGGATGA
4481 CAAGGCTTTATTTGTAAATATGCTCTTAATATGCAACTTTGAGAATAAAATAGAAACATCATGTATTTTAAAATATAAGA
4561 TGAAGTGTGACGCACTGTATACAATTTAATATATATTTTTAGGGTTTTGTTATTTAAGAAAATGGAATGTAATGGTACTT
4641 TTACAAAAGAGAAAAAATGTTATTTTTACTTTCTGGAAAAAATAAATATTCTCATTGTTGTAGAAAGAAAAAAAAAAAAA
4721 AA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuauuCUGGUAGAA----AAGGAGUu 5'
               | |: | ||    ||||||| 
Target 5' ctggtGTCTTTGTTTACCTTCCTCAc 3'
 4092 - 4117 143.00 -9.10
2 
miRNA  3' uuaUUCUGGUAGAAAAGGAGUu 5'
             ::|: || |  ||||||: 
Target 5' agcGGGGGCAGCACTTCCTCGg 3'
 2748 - 2769 135.00 -13.20
3 
miRNA  3' uuAUUCUGG----UAGAAAAGGAGuu 5'
            |::|| :    ||: |||||||  
Target 5' ctTGGGAGTTTGGATTGTTTCCTCtg 3'
 4069 - 4094 134.00 -8.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM2936158 4 COSMIC
COSN30531237 9 COSMIC
COSN31479645 38 COSMIC
COSN28195691 53 COSMIC
COSN30135008 57 COSMIC
COSN25108709 71 COSMIC
COSN30168171 73 COSMIC
COSN30513797 78 COSMIC
COSN30163930 90 COSMIC
COSN19769123 135 COSMIC
COSN29694571 1280 COSMIC
COSN7052417 1323 COSMIC
COSN25849909 1555 COSMIC
COSN16046222 1895 COSMIC
COSN20762764 1900 COSMIC
COSN5990638 1917 COSMIC
COSN22517146 1978 COSMIC
COSN8016155 2268 COSMIC
COSN15191162 2573 COSMIC
COSN21738465 2586 COSMIC
COSN9163772 2994 COSMIC
COSN9163773 3158 COSMIC
COSN28646974 3924 COSMIC
COSN26678895 3994 COSMIC
COSN26644480 4028 COSMIC
COSN26572772 4034 COSMIC
COSN27638298 4055 COSMIC
COSN10029299 4082 COSMIC
COSN20117345 4085 COSMIC
COSN31595476 4295 COSMIC
COSN31551978 4378 COSMIC
COSN31531227 4560 COSMIC
rs713728 369 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs758464243 4 dbSNP
rs764121134 7 dbSNP
rs751436235 9 dbSNP
rs1030786556 10 dbSNP
rs757092168 11 dbSNP
rs780161903 14 dbSNP
rs749485871 15 dbSNP
rs370283850 22 dbSNP
rs1159966696 33 dbSNP
rs1408196447 41 dbSNP
rs748925110 48 dbSNP
rs373338436 52 dbSNP
rs543492962 53 dbSNP
rs564879373 60 dbSNP
rs1356877882 69 dbSNP
rs1201928403 70 dbSNP
rs879042761 73 dbSNP
rs1016303725 85 dbSNP
rs1228457105 91 dbSNP
rs1380706968 94 dbSNP
rs1278304725 103 dbSNP
rs1442046187 111 dbSNP
rs1048024814 113 dbSNP
rs868276740 114 dbSNP
rs532207399 119 dbSNP
rs1486325994 123 dbSNP
rs530410219 139 dbSNP
rs199927010 143 dbSNP
rs144273377 145 dbSNP
rs1365238859 152 dbSNP
rs1001727561 156 dbSNP
rs972216456 158 dbSNP
rs1405795597 159 dbSNP
rs1056083085 160 dbSNP
rs919494379 164 dbSNP
rs1184140668 165 dbSNP
rs1489795159 166 dbSNP
rs895968861 167 dbSNP
rs1221765100 174 dbSNP
rs1426561376 176 dbSNP
rs539848829 202 dbSNP
rs1201289638 203 dbSNP
rs6006025 212 dbSNP
rs1020879538 213 dbSNP
rs1403547901 214 dbSNP
rs992506146 219 dbSNP
rs1429975227 230 dbSNP
rs1469224050 235 dbSNP
rs1294345295 237 dbSNP
rs1173637793 238 dbSNP
rs772433478 240 dbSNP
rs1158528924 241 dbSNP
rs1457816071 243 dbSNP
rs1412695120 251 dbSNP
rs1000304593 254 dbSNP
rs1287882216 258 dbSNP
rs1032999753 264 dbSNP
rs1359385617 269 dbSNP
rs1203449382 282 dbSNP
rs1266343982 292 dbSNP
rs1388933831 310 dbSNP
rs953394087 313 dbSNP
rs527905440 316 dbSNP
rs1284326226 325 dbSNP
rs576627978 337 dbSNP
rs560051894 343 dbSNP
rs1270120795 347 dbSNP
rs1270647098 353 dbSNP
rs1317554345 356 dbSNP
rs1222144209 363 dbSNP
rs1323290199 366 dbSNP
rs1302356292 367 dbSNP
rs713728 369 dbSNP
rs934454029 387 dbSNP
rs1360197085 394 dbSNP
rs965684002 400 dbSNP
rs976585749 404 dbSNP
rs1390845536 414 dbSNP
rs918436609 415 dbSNP
rs1052969699 417 dbSNP
rs1376891977 420 dbSNP
rs1176569594 432 dbSNP
rs1434662218 434 dbSNP
rs753305290 449 dbSNP
rs933934857 450 dbSNP
rs929707198 451 dbSNP
rs537846231 452 dbSNP
rs758912071 458 dbSNP
rs1201400574 472 dbSNP
rs1269250828 473 dbSNP
rs1464959111 476 dbSNP
rs556091153 480 dbSNP
rs571317184 483 dbSNP
rs1202351192 492 dbSNP
rs1483186048 496 dbSNP
rs1197127792 500 dbSNP
rs1235963744 503 dbSNP
rs889074902 505 dbSNP
rs1007532584 509 dbSNP
rs1419191149 510 dbSNP
rs1016272548 513 dbSNP
rs1229343901 516 dbSNP
rs909542431 524 dbSNP
rs1312968208 526 dbSNP
rs1451961594 527 dbSNP
rs899283316 528 dbSNP
rs1467451130 531 dbSNP
rs937045758 538 dbSNP
rs1167587301 540 dbSNP
rs993605737 546 dbSNP
rs1391515741 547 dbSNP
rs1426095363 556 dbSNP
rs1181271571 557 dbSNP
rs896034823 558 dbSNP
rs778053919 560 dbSNP
rs1026941611 561 dbSNP
rs747399253 566 dbSNP
rs1274310195 573 dbSNP
rs1206182013 575 dbSNP
rs1041872580 582 dbSNP
rs762149302 582 dbSNP
rs1000274818 589 dbSNP
rs1341132981 590 dbSNP
rs960313365 598 dbSNP
rs1397650148 614 dbSNP
rs189783539 626 dbSNP
rs12170250 631 dbSNP
rs1430131156 635 dbSNP
rs1372085100 644 dbSNP
rs1019378639 656 dbSNP
rs764582843 662 dbSNP
rs965303827 669 dbSNP
rs970105296 681 dbSNP
rs1190254158 686 dbSNP
rs1417814060 693 dbSNP
rs780940393 710 dbSNP
rs1183410982 713 dbSNP
rs1484231403 714 dbSNP
rs151149772 728 dbSNP
rs1292254319 731 dbSNP
rs1490112926 740 dbSNP
rs918404309 743 dbSNP
rs1267247818 747 dbSNP
rs1219934148 758 dbSNP
rs1246940506 763 dbSNP
rs1327046512 764 dbSNP
rs181328019 765 dbSNP
rs1480908817 766 dbSNP
rs6006026 769 dbSNP
rs1321194112 774 dbSNP
rs1405096143 781 dbSNP
rs934421564 782 dbSNP
rs983831822 786 dbSNP
rs1446107254 788 dbSNP
rs988635887 790 dbSNP
rs576361015 804 dbSNP
rs1450974704 808 dbSNP
rs1411945651 809 dbSNP
rs543752325 810 dbSNP
rs1050083694 812 dbSNP
rs937093964 820 dbSNP
rs1452362192 826 dbSNP
rs1423188026 831 dbSNP
rs1331276054 836 dbSNP
rs889721850 837 dbSNP
rs6006027 842 dbSNP
rs1267433623 854 dbSNP
rs1296537109 855 dbSNP
rs1037687537 856 dbSNP
rs1385018553 860 dbSNP
rs899250760 868 dbSNP
rs1232222937 872 dbSNP
rs1331381716 875 dbSNP
rs1247028229 877 dbSNP
rs993579879 878 dbSNP
rs1325094000 889 dbSNP
rs777182691 891 dbSNP
rs916919658 891 dbSNP
rs1243568418 895 dbSNP
rs761855648 899 dbSNP
rs1026409134 900 dbSNP
rs1478548091 903 dbSNP
rs745351460 906 dbSNP
rs950317930 910 dbSNP
rs12170397 911 dbSNP
rs568589593 912 dbSNP
rs1248667546 923 dbSNP
rs970327285 926 dbSNP
rs1462301756 937 dbSNP
rs1183645594 938 dbSNP
rs978405109 942 dbSNP
rs1466228031 958 dbSNP
rs1242210326 961 dbSNP
rs1199716101 971 dbSNP
rs1345452726 976 dbSNP
rs183523521 987 dbSNP
rs936116326 988 dbSNP
rs1170011884 990 dbSNP
rs1420596187 993 dbSNP
rs1409917117 994 dbSNP
rs1168901497 995 dbSNP
rs1436607597 1001 dbSNP
rs1471776723 1011 dbSNP
rs1054636890 1014 dbSNP
rs889178523 1018 dbSNP
rs1415407716 1039 dbSNP
rs1008077544 1052 dbSNP
rs762912044 1053 dbSNP
rs188158221 1054 dbSNP
rs998102884 1057 dbSNP
rs1336142764 1058 dbSNP
rs1390982394 1058 dbSNP
rs1190649856 1061 dbSNP
rs1235736561 1062 dbSNP
rs147727103 1062 dbSNP
rs951301992 1062 dbSNP
rs922393636 1074 dbSNP
rs983884292 1078 dbSNP
rs955353342 1091 dbSNP
rs985338244 1098 dbSNP
rs911108674 1106 dbSNP
rs958458000 1117 dbSNP
rs941319107 1119 dbSNP
rs527875076 1123 dbSNP
rs1376261447 1147 dbSNP
rs1284139389 1150 dbSNP
rs920564107 1163 dbSNP
rs929313127 1170 dbSNP
rs1306606398 1171 dbSNP
rs1339786411 1174 dbSNP
rs1213743136 1178 dbSNP
rs1256135099 1184 dbSNP
rs1371462236 1188 dbSNP
rs549357768 1196 dbSNP
rs1170708158 1200 dbSNP
rs1403684991 1204 dbSNP
rs567522780 1208 dbSNP
rs1325576816 1211 dbSNP
rs531844414 1212 dbSNP
rs1203827158 1216 dbSNP
rs141373105 1217 dbSNP
rs1259490432 1226 dbSNP
rs1044593395 1232 dbSNP
rs117583100 1234 dbSNP
rs1252178554 1236 dbSNP
rs1206785206 1257 dbSNP
rs774236048 1269 dbSNP
rs57287754 1271 dbSNP
rs1459711184 1272 dbSNP
rs145095696 1292 dbSNP
rs1054607612 1297 dbSNP
rs1033265186 1307 dbSNP
rs1286984181 1313 dbSNP
rs1409668693 1316 dbSNP
rs989182540 1317 dbSNP
rs943451389 1319 dbSNP
rs955667370 1322 dbSNP
rs544469111 1323 dbSNP
rs1165624628 1324 dbSNP
rs1407134114 1341 dbSNP
rs1420009932 1349 dbSNP
rs1156853174 1351 dbSNP
rs554231399 1353 dbSNP
rs531436376 1354 dbSNP
rs138894698 1357 dbSNP
rs545593526 1358 dbSNP
rs1245745081 1359 dbSNP
rs547971303 1360 dbSNP
rs1319277420 1361 dbSNP
rs886996715 1363 dbSNP
rs1266781694 1365 dbSNP
rs759520692 1367 dbSNP
rs1429840552 1368 dbSNP
rs1276066828 1369 dbSNP
rs1005443373 1380 dbSNP
rs1223980706 1381 dbSNP
rs576322076 1385 dbSNP
rs918523702 1390 dbSNP
rs929280539 1397 dbSNP
rs1047753050 1400 dbSNP
rs5763003 1402 dbSNP
rs950202014 1403 dbSNP
rs1412580733 1406 dbSNP
rs1284575683 1407 dbSNP
rs1044881848 1408 dbSNP
rs143693999 1413 dbSNP
rs368964728 1414 dbSNP
rs534047515 1417 dbSNP
rs181744257 1418 dbSNP
rs1245619773 1420 dbSNP
rs375857573 1423 dbSNP
rs1465779499 1424 dbSNP
rs371336766 1427 dbSNP
rs574402671 1428 dbSNP
rs1471229740 1430 dbSNP
rs541917199 1431 dbSNP
rs955290601 1434 dbSNP
rs1006609880 1445 dbSNP
rs1302252187 1446 dbSNP
rs132279 1447 dbSNP
rs1435874331 1451 dbSNP
rs1389358456 1458 dbSNP
rs58849768 1459 dbSNP
rs550047332 1461 dbSNP
rs1296128775 1462 dbSNP
rs1358298656 1463 dbSNP
rs973892754 1463 dbSNP
rs1176366711 1466 dbSNP
rs1187443878 1467 dbSNP
rs1387905967 1467 dbSNP
rs1025503773 1473 dbSNP
rs1264564532 1475 dbSNP
rs951355193 1476 dbSNP
rs1040548628 1482 dbSNP
rs565278518 1487 dbSNP
rs566824542 1490 dbSNP
rs532534236 1491 dbSNP
rs1240628466 1492 dbSNP
rs1047695868 1493 dbSNP
rs1328204529 1494 dbSNP
rs950096796 1495 dbSNP
rs538780689 1497 dbSNP
rs547427805 1499 dbSNP
rs1349505926 1500 dbSNP
rs1303257729 1501 dbSNP
rs1436334681 1502 dbSNP
rs980158382 1503 dbSNP
rs927374257 1504 dbSNP
rs936140755 1505 dbSNP
rs1054650622 1520 dbSNP
rs191063153 1523 dbSNP
rs946351177 1528 dbSNP
rs1440055018 1532 dbSNP
rs536317076 1537 dbSNP
rs1257452210 1540 dbSNP
rs1182625415 1543 dbSNP
rs894395859 1545 dbSNP
rs372810998 1547 dbSNP
rs8135766 1548 dbSNP
rs1024157136 1553 dbSNP
rs1386058945 1555 dbSNP
rs1006988392 1556 dbSNP
rs1321102675 1562 dbSNP
rs1293819973 1563 dbSNP
rs1302287374 1567 dbSNP
rs1391561326 1575 dbSNP
rs370591756 1579 dbSNP
rs1456955842 1583 dbSNP
rs1392995229 1585 dbSNP
rs1328960236 1586 dbSNP
rs1167642094 1587 dbSNP
rs1334623795 1588 dbSNP
rs1443899675 1594 dbSNP
rs1316780110 1597 dbSNP
rs1359698164 1605 dbSNP
rs1183195195 1606 dbSNP
rs1245787077 1607 dbSNP
rs998626783 1608 dbSNP
rs1263978000 1609 dbSNP
rs1209380491 1610 dbSNP
rs537275078 1615 dbSNP
rs1196839247 1617 dbSNP
rs558879785 1618 dbSNP
rs1326844020 1624 dbSNP
rs1287534213 1630 dbSNP
rs1337219946 1630 dbSNP
rs1361833477 1630 dbSNP
rs1321170339 1632 dbSNP
rs575795190 1638 dbSNP
rs1385735697 1641 dbSNP
rs1456533061 1642 dbSNP
rs1031326021 1649 dbSNP
rs1328539069 1658 dbSNP
rs1185472932 1661 dbSNP
rs957062269 1662 dbSNP
rs990400493 1668 dbSNP
rs1471355394 1671 dbSNP
rs1017951925 1680 dbSNP
rs1433859104 1691 dbSNP
rs910758182 1691 dbSNP
rs964999608 1695 dbSNP
rs976629088 1706 dbSNP
rs1444226662 1707 dbSNP
rs1463526184 1714 dbSNP
rs1267414203 1715 dbSNP
rs923482562 1716 dbSNP
rs1352489333 1720 dbSNP
rs1272727743 1721 dbSNP
rs150810838 1729 dbSNP
rs1366438493 1730 dbSNP
rs1371128189 1731 dbSNP
rs995283175 1733 dbSNP
rs1432241116 1737 dbSNP
rs1365184549 1744 dbSNP
rs1319555700 1749 dbSNP
rs909214106 1751 dbSNP
rs1400441001 1753 dbSNP
rs1172237765 1760 dbSNP
rs1025471206 1763 dbSNP
rs138184402 1765 dbSNP
rs1397094240 1783 dbSNP
rs1055139614 1787 dbSNP
rs894353779 1788 dbSNP
rs992049960 1791 dbSNP
rs1444017104 1792 dbSNP
rs1012852313 1794 dbSNP
rs548521663 1794 dbSNP
rs1045954484 1798 dbSNP
rs1025329893 1804 dbSNP
rs552653662 1809 dbSNP
rs574388829 1810 dbSNP
rs1348216868 1811 dbSNP
rs913548425 1815 dbSNP
rs1031466632 1820 dbSNP
rs957113982 1822 dbSNP
rs971392417 1824 dbSNP
rs143664391 1839 dbSNP
rs1333971583 1846 dbSNP
rs965307973 1848 dbSNP
rs1377571576 1849 dbSNP
rs976386159 1856 dbSNP
rs1429199954 1858 dbSNP
rs1420251269 1860 dbSNP
rs927341828 1868 dbSNP
rs1030904141 1872 dbSNP
rs1476373120 1873 dbSNP
rs936108286 1874 dbSNP
rs950919962 1883 dbSNP
rs983586515 1885 dbSNP
rs1485875387 1888 dbSNP
rs1259191442 1893 dbSNP
rs990307135 1902 dbSNP
rs1340872179 1907 dbSNP
rs147197358 1909 dbSNP
rs946212023 1910 dbSNP
rs181754869 1919 dbSNP
rs1051332152 1927 dbSNP
rs1284119959 1934 dbSNP
rs891387143 1956 dbSNP
rs1357692661 1961 dbSNP
rs942369307 1968 dbSNP
rs1306423206 1977 dbSNP
rs1039368990 1978 dbSNP
rs898249154 1981 dbSNP
rs1409393777 1984 dbSNP
rs1328526113 1986 dbSNP
rs757670032 1987 dbSNP
rs543656323 1988 dbSNP
rs995251856 1995 dbSNP
rs1251291311 1996 dbSNP
rs1316579949 2002 dbSNP
rs565140628 2003 dbSNP
rs1025356775 2014 dbSNP
rs16987153 2031 dbSNP
rs1013850174 2035 dbSNP
rs1024878377 2036 dbSNP
rs1449306119 2049 dbSNP
rs907035568 2050 dbSNP
rs934444417 2051 dbSNP
rs1337440743 2052 dbSNP
rs796899595 2063 dbSNP
rs892863873 2066 dbSNP
rs1001532074 2070 dbSNP
rs1281488782 2077 dbSNP
rs1034383782 2082 dbSNP
rs548088004 2086 dbSNP
rs957363581 2092 dbSNP
rs990191237 2094 dbSNP
rs563644939 2096 dbSNP
rs1325169495 2098 dbSNP
rs12485095 2099 dbSNP
rs998169020 2107 dbSNP
rs1177985053 2111 dbSNP
rs1423937519 2115 dbSNP
rs1418278569 2119 dbSNP
rs1408269049 2121 dbSNP
rs1178517143 2132 dbSNP
rs6006028 2134 dbSNP
rs950975093 2140 dbSNP
rs983553977 2147 dbSNP
rs987405361 2148 dbSNP
rs186927604 2149 dbSNP
rs1266764742 2150 dbSNP
rs1386651539 2151 dbSNP
rs34594560 2153 dbSNP
rs912797956 2166 dbSNP
rs1295300019 2169 dbSNP
rs1339091764 2174 dbSNP
rs942994714 2180 dbSNP
rs575217570 2181 dbSNP
rs6006029 2198 dbSNP
rs930997499 2203 dbSNP
rs552351982 2204 dbSNP
rs1262778613 2218 dbSNP
rs982525746 2224 dbSNP
rs1205511736 2225 dbSNP
rs1318380920 2229 dbSNP
rs1452804097 2232 dbSNP
rs1262132799 2240 dbSNP
rs570634758 2247 dbSNP
rs1345515713 2248 dbSNP
rs928504241 2249 dbSNP
rs565433044 2250 dbSNP
rs934579708 2252 dbSNP
rs1394073635 2263 dbSNP
rs59762117 2267 dbSNP
rs1013400796 2268 dbSNP
rs1046696677 2276 dbSNP
rs892999216 2278 dbSNP
rs1432142258 2304 dbSNP
rs966369128 2310 dbSNP
rs905099516 2311 dbSNP
rs1002085085 2317 dbSNP
rs1032261644 2318 dbSNP
rs1346664146 2319 dbSNP
rs1262827551 2323 dbSNP
rs1208422135 2346 dbSNP
rs779555004 2349 dbSNP
rs1281292519 2350 dbSNP
rs149693993 2354 dbSNP
rs8141093 2357 dbSNP
rs967892034 2362 dbSNP
rs1407327733 2371 dbSNP
rs1304333687 2387 dbSNP
rs1381537677 2390 dbSNP
rs114710335 2392 dbSNP
rs142508839 2417 dbSNP
rs912758040 2418 dbSNP
rs574948309 2425 dbSNP
rs964188960 2427 dbSNP
rs1374542032 2431 dbSNP
rs1005113225 2432 dbSNP
rs975597301 2435 dbSNP
rs963611136 2442 dbSNP
rs1238539906 2447 dbSNP
rs1285083927 2450 dbSNP
rs545504528 2451 dbSNP
rs1444260066 2457 dbSNP
rs1485548268 2464 dbSNP
rs549353374 2471 dbSNP
rs558695160 2474 dbSNP
rs930966842 2476 dbSNP
rs971229637 2481 dbSNP
rs114127861 2483 dbSNP
rs16987164 2489 dbSNP
rs1488114180 2498 dbSNP
rs1228213258 2502 dbSNP
rs949190155 2503 dbSNP
rs1297628437 2505 dbSNP
rs955924121 2508 dbSNP
rs768672274 2516 dbSNP
rs988757420 2519 dbSNP
rs1416204896 2521 dbSNP
rs914400944 2522 dbSNP
rs1046153085 2523 dbSNP
rs947280800 2529 dbSNP
rs904985890 2530 dbSNP
rs1163212165 2531 dbSNP
rs376883591 2539 dbSNP
rs1378061919 2541 dbSNP
rs371534321 2548 dbSNP
rs5763004 2550 dbSNP
rs1427012768 2552 dbSNP
rs1039287257 2556 dbSNP
rs865883176 2560 dbSNP
rs1053676412 2581 dbSNP
rs774468890 2582 dbSNP
rs1481618770 2584 dbSNP
rs1253024176 2586 dbSNP
rs1211692659 2588 dbSNP
rs1333935064 2590 dbSNP
rs1293726961 2602 dbSNP
rs545465916 2604 dbSNP
rs530029817 2605 dbSNP
rs1305850079 2606 dbSNP
rs144475295 2609 dbSNP
rs1374099585 2611 dbSNP
rs766787504 2616 dbSNP
rs1037954886 2630 dbSNP
rs563674110 2632 dbSNP
rs1008695992 2633 dbSNP
rs1019699910 2638 dbSNP
rs1167619559 2639 dbSNP
rs1363440219 2640 dbSNP
rs761677160 2640 dbSNP
rs1182726314 2641 dbSNP
rs964151314 2642 dbSNP
rs17451302 2643 dbSNP
rs552428396 2645 dbSNP
rs1215406084 2649 dbSNP
rs1348195638 2651 dbSNP
rs114199238 2660 dbSNP
rs373563943 2661 dbSNP
rs1300689300 2663 dbSNP
rs1219218843 2669 dbSNP
rs953004115 2673 dbSNP
rs1234143072 2676 dbSNP
rs1372441421 2679 dbSNP
rs1480695163 2684 dbSNP
rs1328431938 2686 dbSNP
rs1030996341 2693 dbSNP
rs982459318 2703 dbSNP
rs1159400746 2711 dbSNP
rs956726068 2737 dbSNP
rs988724590 2740 dbSNP
rs1173158945 2744 dbSNP
rs908167709 2751 dbSNP
rs759746584 2752 dbSNP
rs1445097471 2753 dbSNP
rs1173214097 2755 dbSNP
rs982243044 2756 dbSNP
rs1355605820 2758 dbSNP
rs1465218894 2762 dbSNP
rs867801118 2768 dbSNP
rs926375600 2769 dbSNP
rs1277741208 2776 dbSNP
rs937815126 2780 dbSNP
rs1232929732 2783 dbSNP
rs1347895522 2800 dbSNP
rs528316511 2801 dbSNP
rs1429193550 2802 dbSNP
rs893726912 2814 dbSNP
rs546569263 2818 dbSNP
rs1042316017 2819 dbSNP
rs132280 2821 dbSNP
rs142508263 2830 dbSNP
rs1275087617 2831 dbSNP
rs1396918037 2833 dbSNP
rs1166196472 2836 dbSNP
rs1019643817 2837 dbSNP
rs1372411002 2838 dbSNP
rs1308003843 2841 dbSNP
rs1448447566 2848 dbSNP
rs1254975980 2852 dbSNP
rs151123228 2855 dbSNP
rs996967757 2856 dbSNP
rs907543314 2857 dbSNP
rs1027143265 2859 dbSNP
rs952888128 2860 dbSNP
rs183097548 2861 dbSNP
rs1183780775 2865 dbSNP
rs899388928 2866 dbSNP
rs1015863653 2870 dbSNP
rs970768699 2873 dbSNP
rs981831451 2874 dbSNP
rs539121825 2885 dbSNP
rs926344375 2899 dbSNP
rs1420931201 2901 dbSNP
rs1395688576 2902 dbSNP
rs937785532 2905 dbSNP
rs1031131528 2907 dbSNP
rs1415339361 2919 dbSNP
rs1168639611 2924 dbSNP
rs1186923943 2928 dbSNP
rs1408323091 2933 dbSNP
rs752122466 2943 dbSNP
rs115384160 2944 dbSNP
rs915044926 2947 dbSNP
rs767851765 2950 dbSNP
rs1436660857 2954 dbSNP
rs1357618440 2955 dbSNP
rs945232561 2962 dbSNP
rs968645267 2963 dbSNP
rs1293109669 2966 dbSNP
rs577353298 2975 dbSNP
rs1357670410 2977 dbSNP
rs1217889676 2979 dbSNP
rs1042674958 2998 dbSNP
rs111677053 3006 dbSNP
rs553385852 3007 dbSNP
rs1041064091 3014 dbSNP
rs1028816325 3016 dbSNP
rs1392175248 3018 dbSNP
rs750762887 3023 dbSNP
rs1440330776 3029 dbSNP
rs1415520870 3030 dbSNP
rs16987166 3035 dbSNP
rs1469204931 3037 dbSNP
rs542546244 3044 dbSNP
rs1179944746 3056 dbSNP
rs1467568216 3067 dbSNP
rs1048464042 3074 dbSNP
rs888587702 3075 dbSNP
rs1337333261 3086 dbSNP
rs1004396330 3091 dbSNP
rs1282447735 3094 dbSNP
rs1223391619 3095 dbSNP
rs1374287840 3110 dbSNP
rs1281398078 3132 dbSNP
rs547985188 3140 dbSNP
rs971029264 3141 dbSNP
rs1003209717 3142 dbSNP
rs1033382130 3143 dbSNP
rs948318587 3147 dbSNP
rs1156538022 3149 dbSNP
rs1399797167 3152 dbSNP
rs563639866 3157 dbSNP
rs755740792 3158 dbSNP
rs1160001131 3159 dbSNP
rs1451957972 3166 dbSNP
rs1045761664 3168 dbSNP
rs530950330 3169 dbSNP
rs1172053201 3172 dbSNP
rs1194753384 3176 dbSNP
rs1489688710 3197 dbSNP
rs186616475 3199 dbSNP
rs915013466 3204 dbSNP
rs1215492739 3207 dbSNP
rs1317809956 3215 dbSNP
rs1286606188 3224 dbSNP
rs878914512 3225 dbSNP
rs939460847 3229 dbSNP
rs1347175038 3233 dbSNP
rs1302614315 3234 dbSNP
rs1360889788 3236 dbSNP
rs1399132866 3245 dbSNP
rs1296318980 3258 dbSNP
rs564637975 3262 dbSNP
rs1369605934 3271 dbSNP
rs1286957364 3275 dbSNP
rs78293984 3279 dbSNP
rs778605833 3282 dbSNP
rs1345419691 3283 dbSNP
rs1299586501 3289 dbSNP
rs977974911 3294 dbSNP
rs546729127 3297 dbSNP
rs911795084 3298 dbSNP
rs944673205 3315 dbSNP
rs1022280537 3318 dbSNP
rs1417978369 3324 dbSNP
rs527606493 3326 dbSNP
rs5844838 3326 dbSNP
rs568170848 3330 dbSNP
rs1029284480 3336 dbSNP
rs1038936328 3337 dbSNP
rs1342453207 3338 dbSNP
rs954632802 3339 dbSNP
rs987238278 3339 dbSNP
rs529118647 3342 dbSNP
rs1287228452 3347 dbSNP
rs734950 3348 dbSNP
rs539060947 3353 dbSNP
rs932670292 3354 dbSNP
rs568494115 3359 dbSNP
rs1271751091 3362 dbSNP
rs920266890 3365 dbSNP
rs1374451312 3369 dbSNP
rs1313020197 3375 dbSNP
rs1467130435 3376 dbSNP
rs947751390 3380 dbSNP
rs1198271339 3395 dbSNP
rs971012303 3399 dbSNP
rs539084279 3405 dbSNP
rs888566158 3412 dbSNP
rs1186220115 3419 dbSNP
rs1475033231 3421 dbSNP
rs778979410 3422 dbSNP
rs1052587589 3427 dbSNP
rs557561553 3432 dbSNP
rs914099282 3433 dbSNP
rs73882480 3434 dbSNP
rs1318469915 3445 dbSNP
rs1259803871 3450 dbSNP
rs906773133 3456 dbSNP
rs1354501735 3461 dbSNP
rs879922236 3465 dbSNP
rs1033935158 3467 dbSNP
rs866475629 3480 dbSNP
rs558984461 3483 dbSNP
rs1322327281 3484 dbSNP
rs1462984196 3486 dbSNP
rs1328804190 3503 dbSNP
rs527834197 3505 dbSNP
rs1418860307 3511 dbSNP
rs1309594457 3513 dbSNP
rs1189815177 3514 dbSNP
rs1010590531 3515 dbSNP
rs189884988 3516 dbSNP
rs1294331662 3521 dbSNP
rs1458202671 3524 dbSNP
rs114711193 3533 dbSNP
rs74423676 3534 dbSNP
rs1014698536 3536 dbSNP
rs911694257 3539 dbSNP
rs965850664 3543 dbSNP
rs557714232 3551 dbSNP
rs1246488820 3562 dbSNP
rs974605341 3564 dbSNP
rs73393085 3572 dbSNP
rs762253284 3579 dbSNP
rs1446870828 3580 dbSNP
rs1379764407 3582 dbSNP
rs546226308 3589 dbSNP
rs141408703 3593 dbSNP
rs143865196 3594 dbSNP
rs78460344 3598 dbSNP
rs1037532514 3599 dbSNP
rs906663246 3600 dbSNP
rs1363422659 3603 dbSNP
rs939518143 3604 dbSNP
rs73393086 3605 dbSNP
rs895430239 3606 dbSNP
rs1010572552 3607 dbSNP
rs1386803709 3608 dbSNP
rs763168061 3614 dbSNP
rs1162626417 3615 dbSNP
rs1388459703 3617 dbSNP
rs1411210151 3618 dbSNP
rs1021994126 3625 dbSNP
rs764229089 3632 dbSNP
rs182453053 3636 dbSNP
rs1375713427 3637 dbSNP
rs529084044 3639 dbSNP
rs1317649624 3640 dbSNP
rs550448124 3643 dbSNP
rs946833141 3654 dbSNP
rs1043907072 3661 dbSNP
rs921318152 3662 dbSNP
rs1298970689 3665 dbSNP
rs562486542 3666 dbSNP
rs1264266998 3671 dbSNP
rs1019126182 3674 dbSNP
rs965820394 3675 dbSNP
rs1453778891 3679 dbSNP
rs1199358445 3681 dbSNP
rs974574298 3686 dbSNP
rs1028846958 3693 dbSNP
rs1456626743 3694 dbSNP
rs73397005 3695 dbSNP
rs984522693 3697 dbSNP
rs1445005616 3698 dbSNP
rs1008762631 3699 dbSNP
rs1036276501 3700 dbSNP
rs146853863 3702 dbSNP
rs940021376 3726 dbSNP
rs1277635245 3730 dbSNP
rs995045059 3733 dbSNP
rs187805870 3734 dbSNP
rs1346410096 3744 dbSNP
rs1424228039 3753 dbSNP
rs1225716466 3754 dbSNP
rs1279116817 3755 dbSNP
rs1326165863 3755 dbSNP
rs1402125959 3758 dbSNP
rs1373849261 3761 dbSNP
rs972819513 3763 dbSNP
rs16987167 3766 dbSNP
rs939488455 3767 dbSNP
rs1055326262 3769 dbSNP
rs45526938 3770 dbSNP
rs946916997 3771 dbSNP
rs1194085042 3773 dbSNP
rs1478631126 3774 dbSNP
rs1001988985 3777 dbSNP
rs1044372275 3782 dbSNP
rs879686639 3783 dbSNP
rs999608870 3787 dbSNP
rs1194545802 3793 dbSNP
rs1339270524 3797 dbSNP
rs1259169172 3798 dbSNP
rs1220838770 3801 dbSNP
rs960399567 3815 dbSNP
rs1292834671 3822 dbSNP
rs1018681415 3823 dbSNP
rs1448873336 3828 dbSNP
rs56186491 3832 dbSNP
rs1326898683 3835 dbSNP
rs1408183728 3838 dbSNP
rs568646538 3840 dbSNP
rs914120466 3850 dbSNP
rs545828850 3851 dbSNP
rs1028819050 3873 dbSNP
rs921467839 3876 dbSNP
rs932718224 3878 dbSNP
rs1472858982 3879 dbSNP
rs951890876 3884 dbSNP
rs984687379 3891 dbSNP
rs746612963 3894 dbSNP
rs536090478 3896 dbSNP
rs912562779 3898 dbSNP
rs1239316511 3899 dbSNP
rs1015274926 3905 dbSNP
rs562096434 3911 dbSNP
rs1328725043 3913 dbSNP
rs1037003418 3914 dbSNP
rs1277678147 3921 dbSNP
rs1316183020 3923 dbSNP
rs138213533 3924 dbSNP
rs539754348 3925 dbSNP
rs1483045159 3926 dbSNP
rs78373934 3931 dbSNP
rs116694917 3936 dbSNP
rs115500841 3937 dbSNP
rs1163773187 3940 dbSNP
rs561883165 3951 dbSNP
rs1194352224 3954 dbSNP
rs1415496598 3955 dbSNP
rs1422804100 3964 dbSNP
rs1156375633 3968 dbSNP
rs1476590383 3971 dbSNP
rs1177602985 3974 dbSNP
rs946893394 3980 dbSNP
rs573494307 3982 dbSNP
rs924214867 3983 dbSNP
rs2301443 3988 dbSNP
rs1222750399 3989 dbSNP
rs979739024 3991 dbSNP
rs1282339077 3992 dbSNP
rs562343293 3994 dbSNP
rs1028905265 3998 dbSNP
rs1354441780 4000 dbSNP
rs1309925319 4001 dbSNP
rs1298166809 4018 dbSNP
rs1368673038 4019 dbSNP
rs193134750 4023 dbSNP
rs1339070382 4024 dbSNP
rs1225501093 4033 dbSNP
rs754510847 4037 dbSNP
rs551400649 4038 dbSNP
rs753600594 4043 dbSNP
rs368896280 4047 dbSNP
rs1311838844 4052 dbSNP
rs1231288123 4054 dbSNP
rs887590643 4055 dbSNP
rs940123374 4060 dbSNP
rs1159903917 4062 dbSNP
rs1453176960 4064 dbSNP
rs1006480273 4075 dbSNP
rs527315297 4080 dbSNP
rs200836090 4083 dbSNP
rs3216846 4083 dbSNP
rs397840316 4083 dbSNP
rs549045127 4086 dbSNP
rs994180693 4090 dbSNP
rs1240602153 4092 dbSNP
rs1034983291 4096 dbSNP
rs1216112410 4107 dbSNP
rs960699547 4110 dbSNP
rs1262475943 4111 dbSNP
rs1049011453 4116 dbSNP
rs1345727912 4117 dbSNP
rs754530758 4120 dbSNP
rs1219603371 4126 dbSNP
rs1267382889 4127 dbSNP
rs1268162844 4138 dbSNP
rs1399061276 4154 dbSNP
rs868004779 4155 dbSNP
rs567408419 4157 dbSNP
rs968229382 4176 dbSNP
rs980030057 4177 dbSNP
rs1173566516 4179 dbSNP
rs1432250751 4189 dbSNP
rs1056322554 4194 dbSNP
rs924212822 4211 dbSNP
rs935617730 4212 dbSNP
rs778498945 4217 dbSNP
rs537943499 4218 dbSNP
rs541492191 4219 dbSNP
rs903553230 4225 dbSNP
rs931669842 4230 dbSNP
rs1482936246 4233 dbSNP
rs138999025 4234 dbSNP
rs540098904 4239 dbSNP
rs758317223 4252 dbSNP
rs887557389 4253 dbSNP
rs777613630 4256 dbSNP
rs1313856206 4260 dbSNP
rs1255978065 4261 dbSNP
rs1006035072 4273 dbSNP
rs753288426 4278 dbSNP
rs1036645372 4279 dbSNP
rs1279633788 4296 dbSNP
rs897664560 4297 dbSNP
rs531758079 4298 dbSNP
rs954449954 4299 dbSNP
rs1468073666 4307 dbSNP
rs1003163002 4308 dbSNP
rs73882484 4310 dbSNP
rs1377928659 4321 dbSNP
rs1240612350 4324 dbSNP
rs1162998515 4325 dbSNP
rs1423356645 4328 dbSNP
rs960668488 4329 dbSNP
rs1183655016 4354 dbSNP
rs746798645 4355 dbSNP
rs1284975398 4356 dbSNP
rs77555916 4361 dbSNP
rs1484231679 4362 dbSNP
rs972825648 4367 dbSNP
rs1023705633 4371 dbSNP
rs1351452414 4380 dbSNP
rs1259625294 4382 dbSNP
rs968575382 4386 dbSNP
rs1265925254 4387 dbSNP
rs1487899091 4388 dbSNP
rs547901551 4389 dbSNP
rs1375337229 4392 dbSNP
rs117305895 4393 dbSNP
rs1402864454 4396 dbSNP
rs555440163 4410 dbSNP
rs1324270394 4416 dbSNP
rs980517481 4419 dbSNP
rs1369262778 4425 dbSNP
rs1167002409 4432 dbSNP
rs1178423005 4443 dbSNP
rs561567691 4446 dbSNP
rs937927705 4449 dbSNP
rs1056291142 4450 dbSNP
rs917783040 4452 dbSNP
rs976284090 4462 dbSNP
rs923540482 4470 dbSNP
rs945101647 4481 dbSNP
rs1265597005 4482 dbSNP
rs931637001 4501 dbSNP
rs1350805227 4502 dbSNP
rs1042180831 4506 dbSNP
rs1241560947 4511 dbSNP
rs183512778 4512 dbSNP
rs1299721247 4518 dbSNP
rs1166174575 4537 dbSNP
rs1386495265 4539 dbSNP
rs1000503052 4542 dbSNP
rs985784165 4543 dbSNP
rs1349796539 4556 dbSNP
rs1360026545 4561 dbSNP
rs1456515617 4568 dbSNP
rs867422064 4572 dbSNP
rs1440302971 4573 dbSNP
rs1333375361 4575 dbSNP
rs1049875073 4582 dbSNP
rs890014345 4585 dbSNP
rs1267643039 4603 dbSNP
rs1211226858 4604 dbSNP
rs1008458687 4605 dbSNP
rs1284754834 4605 dbSNP
rs1446262093 4606 dbSNP
rs1216694424 4619 dbSNP
rs1356467841 4629 dbSNP
rs1273524725 4636 dbSNP
rs132281 4649 dbSNP
rs1331998494 4652 dbSNP
rs961561932 4659 dbSNP
rs1036113786 4662 dbSNP
rs994297906 4671 dbSNP
rs897629101 4680 dbSNP
rs938507936 4684 dbSNP
rs1027036278 4694 dbSNP
rs1298952121 4694 dbSNP
rs1057056827 4695 dbSNP
rs1421522005 4702 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uuauucugguagaaAAGGAGUu 5'
                        ||||||| 
Target 5' --------uuuaccUUCCUCAc 3'
 		1 - 14
Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177608. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_2_10 PAR-CLIP data was present in ERX177617. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_3_7 PAR-CLIP data was present in ERX177629. RNA binding protein: AGO2. Condition:KO_D_AGO_CLIP_4_7 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_001039570 | 3UTR | ACCUUCCUCACUGUUCUACCUCCUGGCCAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000400335.4 | 3UTR | UUUACCUUCCUCACUGUUCUACCUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
111 hsa-miR-3915 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT059544 PIP5K1A phosphatidylinositol-4-phosphate 5-kinase type 1 alpha 2 2
MIRT081703 ZNF507 zinc finger protein 507 2 2
MIRT083311 ZCCHC3 zinc finger CCHC-type containing 3 2 6
MIRT119046 SFT2D3 SFT2 domain containing 3 2 2
MIRT189381 TXLNA taxilin alpha 2 4
MIRT195895 C16ORF72 chromosome 16 open reading frame 72 2 6
MIRT223807 OXR1 oxidation resistance 1 2 2
MIRT292954 ZNF146 zinc finger protein 146 2 4
MIRT293949 RPL13A ribosomal protein L13a 2 6
MIRT300900 KREMEN1 kringle containing transmembrane protein 1 2 2
MIRT339332 SESN2 sestrin 2 2 2
MIRT349304 ZNF317 zinc finger protein 317 2 2
MIRT364736 TOR1B torsin family 1 member B 2 2
MIRT366233 VMA21 VMA21, vacuolar ATPase assembly factor 2 2
MIRT384605 CLIC4 chloride intracellular channel 4 2 2
MIRT401745 HLA-DRA major histocompatibility complex, class II, DR alpha 2 2
MIRT443169 UBL3 ubiquitin like 3 2 2
MIRT444215 METTL12 methyltransferase like 12 2 2
MIRT444375 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT445340 TCEANC transcription elongation factor A N-terminal and central domain containing 2 2
MIRT445474 KDM6A lysine demethylase 6A 2 2
MIRT445598 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT445630 TMEM50A transmembrane protein 50A 2 2
MIRT446012 VNN1 vanin 1 2 2
MIRT446115 ASTN1 astrotactin 1 2 2
MIRT446248 ELP2 elongator acetyltransferase complex subunit 2 2 2
MIRT446382 SYNCRIP synaptotagmin binding cytoplasmic RNA interacting protein 2 2
MIRT446940 ZMAT3 zinc finger matrin-type 3 2 2
MIRT446967 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT447178 PGRMC2 progesterone receptor membrane component 2 2 2
MIRT447209 APBB2 amyloid beta precursor protein binding family B member 2 2 2
MIRT447237 IHH indian hedgehog 2 2
MIRT447807 EMX1 empty spiracles homeobox 1 2 2
MIRT447853 RRP8 ribosomal RNA processing 8 2 4
MIRT448054 MMP15 matrix metallopeptidase 15 2 2
MIRT448094 RASD2 RASD family member 2 2 2
MIRT448704 KLHL11 kelch like family member 11 2 2
MIRT448851 FEM1C fem-1 homolog C 2 2
MIRT449488 ZBTB4 zinc finger and BTB domain containing 4 2 2
MIRT449785 C1orf109 chromosome 1 open reading frame 109 2 2
MIRT450774 PDE3A phosphodiesterase 3A 2 2
MIRT451124 ZNF99 zinc finger protein 99 2 2
MIRT452676 GPR156 G protein-coupled receptor 156 2 2
MIRT452888 PSD4 pleckstrin and Sec7 domain containing 4 2 2
MIRT453188 ACSF2 acyl-CoA synthetase family member 2 2 2
MIRT453353 ZNF3 zinc finger protein 3 2 2
MIRT454502 ZFYVE27 zinc finger FYVE-type containing 27 2 2
MIRT454629 FAM83H family with sequence similarity 83 member H 2 2
MIRT455183 AGTRAP angiotensin II receptor associated protein 2 2
MIRT458204 FOXL2 forkhead box L2 2 2
MIRT458723 CES2 carboxylesterase 2 2 2
MIRT458942 SAMD4B sterile alpha motif domain containing 4B 2 2
MIRT460304 FLCN folliculin 2 2
MIRT460989 SYT7 synaptotagmin 7 2 2
MIRT461697 ZNF426 zinc finger protein 426 2 2
MIRT461903 NECAB3 N-terminal EF-hand calcium binding protein 3 2 2
MIRT462193 NDUFS1 NADH:ubiquinone oxidoreductase core subunit S1 2 2
MIRT462290 PPM1H protein phosphatase, Mg2+/Mn2+ dependent 1H 2 2
MIRT463795 XPOT exportin for tRNA 2 2
MIRT464649 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 4
MIRT465911 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 4
MIRT465992 TMEM189 transmembrane protein 189 2 4
MIRT466302 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT466575 TBC1D2B TBC1 domain family member 2B 2 2
MIRT470558 POU2F1 POU class 2 homeobox 1 2 2
MIRT471333 PERP PERP, TP53 apoptosis effector 2 2
MIRT471659 PALM2 paralemmin 2 2 2
MIRT472363 TSPAN1 tetraspanin 1 2 2
MIRT473468 MCFD2 multiple coagulation factor deficiency 2 2 2
MIRT474702 KIF3A kinesin family member 3A 2 2
MIRT476067 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT476077 GRB2 growth factor receptor bound protein 2 2 2
MIRT476423 GBA2 glucosylceramidase beta 2 2 2
MIRT476463 GATAD2B GATA zinc finger domain containing 2B 2 2
MIRT477877 DYNLL2 dynein light chain LC8-type 2 2 2
MIRT478240 DDX3X DEAD-box helicase 3, X-linked 2 4
MIRT479460 CDK6 cyclin dependent kinase 6 2 2
MIRT481030 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 2
MIRT491496 HLA-DOA major histocompatibility complex, class II, DO alpha 2 2
MIRT497585 SLC23A1 solute carrier family 23 member 1 2 2
MIRT498542 TMEM30B transmembrane protein 30B 2 2
MIRT499263 NBPF11 NBPF member 11 2 2
MIRT504698 ZNF117 zinc finger protein 117 2 2
MIRT511288 KLHL15 kelch like family member 15 2 4
MIRT523121 HSP90B1 heat shock protein 90 beta family member 1 2 4
MIRT529601 H1F0 H1 histone family member 0 2 2
MIRT533481 TRIM71 tripartite motif containing 71 2 2
MIRT535571 NUP37 nucleoporin 37 2 4
MIRT537869 EDA2R ectodysplasin A2 receptor 2 2
MIRT538010 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 2
MIRT552681 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 4
MIRT554986 RAB39B RAB39B, member RAS oncogene family 2 2
MIRT556659 KMT2D lysine methyltransferase 2D 2 4
MIRT557437 GTPBP2 GTP binding protein 2 2 2
MIRT560813 CRTAP cartilage associated protein 2 2
MIRT562115 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT563103 IFRD2 interferon related developmental regulator 2 2 2
MIRT574199 LMNB1 lamin B1 2 2
MIRT623920 FMNL3 formin like 3 2 2
MIRT626551 NMNAT2 nicotinamide nucleotide adenylyltransferase 2 2 2
MIRT645458 ANKS6 ankyrin repeat and sterile alpha motif domain containing 6 2 2
MIRT649082 CACNA1B calcium voltage-gated channel subunit alpha1 B 2 2
MIRT659477 CLDN1 claudin 1 2 2
MIRT667950 HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 2 2
MIRT701981 MIER3 MIER family member 3 2 2
MIRT708694 TFDP2 transcription factor Dp-2 2 2
MIRT709649 DFFB DNA fragmentation factor subunit beta 2 2
MIRT710090 FAM229B family with sequence similarity 229 member B 2 2
MIRT718396 ALDH1A3 aldehyde dehydrogenase 1 family member A3 2 2
MIRT724972 TNS1 tensin 1 2 2
MIRT756050 HRH4 histamine receptor H4 2 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-3915 Paclitaxel 36314 NSC125973 approved resistant High Prostate Cancer cell line (DU-145, PC-3)
hsa-miR-3915 Cisplatin + Decitabine sensitive High Non-Small Cell Lung Cancer cell line (A549)
hsa-mir-3915 Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-3915 Tripterygium wilfordii Hook F sensitive tissue
hsa-miR-3915 Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-3915 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-3915 Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)

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