miRTarBase - #MIRT304688


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pre-miRNA Information
pre-miRNA hsa-mir-561   
Genomic Coordinates chr2: 188297492 - 188297588
Synonyms MIRN561, hsa-mir-561, MIR561
Description Homo sapiens miR-561 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-561-3p
Sequence 61| CAAAGUUUAAGAUCCUUGAAGU |82
Evidence Experimental
Experiments SAGE
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 3 2 + 188297554 26449202, 27587585, 29233923 MiREDiBase
A-to-I 4 2 + 188297555 26449202, 27587585, 29233923 MiREDiBase
A-to-I 9 2 + 188297560 26449202, 27587585, 29267965, 29165639 MiREDiBase
A-to-I 10 2 + 188297561 26449202, 27587585, 29233923 MiREDiBase
A-to-I 19 2 + 188297570 29233923 MiREDiBase
A-to-I 20 2 + 188297571 26449202, 27587585, 29233923 MiREDiBase
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN16051820 1 COSMIC
COSN30152233 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1050331859 4 dbSNP
rs1308584826 15 dbSNP
rs1022262507 18 dbSNP
rs1317728266 20 dbSNP
Putative Targets

Gene Information
Gene Symbol GTF2E1   
Synonyms FE, TF2E1, TFIIE-A
Description general transcription factor IIE subunit 1
Transcript NM_005513   
Expression
Putative miRNA Targets on GTF2E1
3'UTR of GTF2E1
(miRNA target sites are highlighted)		 
>GTF2E1|NM_005513|3'UTR
   1 GCTTTCCCTAATTCTTTCTCCTTTCTCTAATGCTCAGTTCAAAAAGGAATGTCTCATCTTTGAAGAAAAGTATTTAAGTG
  81 GCTTTCTGCCCCTCTTGATGTAAGCAACTGTCCATCCTTGTGCAAAGATTGATGGTAGAGAGTTTGACTTTTATGCCAGA
 161 AACTTTCCCAGCAAGGTAGGGTGCTGAGAATCCTACCCTTCCTTGCTGTCACTACAGTATTAATATTTTACTGTATTTTC
 241 TTTTCTTTTTTTTTTTTTTTTGGAGATGAAGTCTCACTCTTGTACCCCAGGCTGGAGTGCAATGGCGTGATCTCGGCTCA
 321 CTGCAACCTCTGCCTCCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAGGTGCCTGCCACC
 401 ATGCCTGGCTAATTTTTGTATTTTTAGTAGAGGCAGGGTTTCACCATGTTAGCCAGGATGATCTCGATCTCCTGACCTCA
 481 TGATCCACCCGCCTCGGCCTCCCAAAGTGCTGTATTTTCTTATCTGATTTTTTTCTTGCCTTATTAAGACATAATTTTCT
 561 CCCTTCTGAAATGAGTGAGGGAAGTTCATAAGGTAAATCCTTCCCATCCATCTGTTTACTACAATAGGTTACAATAATTC
 641 ACTGATCACATCCATTTTATCTGTTCTAGCCAGGCATTCCAAACAATTTCTTATACTGCTGCCCACCAAAGCAGCTTGCC
 721 AACAGTCAAATCACTGATTGGGGGAAAAAATCCTGAAATTTTGCTTAGAATTTGAGCATTTCCTCAAAATTGAGATGGAT
 801 CAATATGTAAGGGGAGGTGGGAGCGTGTGTGGAAGGGGGAGAGATATACTTGAGTCTTATGATTAATGTCTAAACCAGAA
 881 TTTGTGTCTTTAGAACTGACCAGACTGGTAGATTTTATTGTATTGCTTAATGTCTTTTGGTTTGGATTTAGGATGATAGA
 961 AAACAGAAGTATAATTGGTAAACCCTTAGGAAGAAATTAGAAAAACATGGACGTAAGACAAGAAGTCTCTGTGAAGGGTT
1041 GAAGAGTGACAAGCATTGGTAACAGTGCCTTAGAACTGTGTCAGTTAGTCTGATTTGGAAATCCTTTATGTAAAGCTGAG
1121 ACTGGTCCTGGTTTTGTTCCCTTTGGGTACAGACCTCTTGTCAGTGCTATAAATTGTTTAATGAGGCCATTCCAGCAGAA
1201 ATCAACAGAATAATTGATTACTCTTCTCTCTCTCTGTCACTCTCCCTCTTTCTAAACATCATTGAAGGCTGTCTCTCTTT
1281 TAATTTTTGTCAGACACAGTATTTTAGGGTGCATCCAGTATACCATTGAGCATTGTAACCTCAGGAAACAGTTTATTTTG
1361 GGTTCTGATATGTAGCATGGTATTTTCCCTAAGGCAGAACTTTAAAAATAAAGAACTTTCACACAAGGGTCTGTAACAAT
1441 TGTATATCTTACAATATTTTTCCTTGCATTGTAATTTTTAAGTATTTATCATTTTATAGTACACATGTAAAGAATATATG
1521 AGCCTTGTATGGAGTGATGTTTCATTTACCTGGGTTGTGTTAATGACTGAATGTTGACAATAAATCTGTTTTATACTGA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugAAGUUCCUAGAAUUUGAAAc 5'
            ||:||  ||   :|||||| 
Target 5' acTTTAAAAATAAAGAACTTTc 3'
 1399 - 1420 140.00 -6.30
2 
miRNA  3' ugaagUUCCUA-GAAUUUGAAAc 5'
               ||  || || |||:||| 
Target 5' ggggaAAAAATCCTGAAATTTTg 3'
 741 - 763 137.00 -6.50
3 
miRNA  3' ugAAGUUCC--UAG-----AAUUUGAAAc 5'
            || ||||  :||     || ||:||| 
Target 5' caTTGAAGGCTGTCTCTCTTTTAATTTTt 3'
 1260 - 1288 114.00 -5.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN1266159 3 COSMIC
COSN30465400 7 COSMIC
COSN30465243 8 COSMIC
COSN31585850 12 COSMIC
COSN31600200 15 COSMIC
COSN30130086 47 COSMIC
COSN31536663 55 COSMIC
COSN30535617 66 COSMIC
COSN30167958 75 COSMIC
COSN31586313 80 COSMIC
COSN9233818 117 COSMIC
COSN1266160 241 COSMIC
COSN1266161 246 COSMIC
COSN32061560 262 COSMIC
COSN31962132 308 COSMIC
COSN7619818 352 COSMIC
COSN15661578 786 COSMIC
COSN9233819 933 COSMIC
COSN5518973 1108 COSMIC
COSN26819865 1351 COSMIC
COSN7814542 1427 COSMIC
COSN1910787 1452 COSMIC
COSN5865647 1524 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs981835702 3 dbSNP
rs779141309 4 dbSNP
rs748185188 5 dbSNP
rs772265595 9 dbSNP
rs777701804 11 dbSNP
rs1310737459 12 dbSNP
rs565073405 14 dbSNP
rs1257011076 16 dbSNP
rs1488235662 17 dbSNP
rs370606908 20 dbSNP
rs747568702 21 dbSNP
rs894355408 26 dbSNP
rs771534610 27 dbSNP
rs1362625032 31 dbSNP
rs929810680 32 dbSNP
rs982704807 35 dbSNP
rs372289349 36 dbSNP
rs1424036880 37 dbSNP
rs1431159939 38 dbSNP
rs1386953106 39 dbSNP
rs1291504674 40 dbSNP
rs1246728740 41 dbSNP
rs201163034 47 dbSNP
rs1375891584 48 dbSNP
rs768414601 49 dbSNP
rs762508583 50 dbSNP
rs1362491250 53 dbSNP
rs1366058675 65 dbSNP
rs374038933 73 dbSNP
rs1446557594 89 dbSNP
rs1237078722 90 dbSNP
rs146406278 92 dbSNP
rs899840601 93 dbSNP
rs1424057695 94 dbSNP
rs776526600 107 dbSNP
rs934023793 108 dbSNP
rs1293087373 121 dbSNP
rs1033037542 126 dbSNP
rs1339527555 127 dbSNP
rs2229308 130 dbSNP
rs868374782 131 dbSNP
rs1298948528 133 dbSNP
rs769842238 136 dbSNP
rs999458411 138 dbSNP
rs1017777315 140 dbSNP
rs1054696059 149 dbSNP
rs893420206 157 dbSNP
rs1427731503 163 dbSNP
rs1010522223 169 dbSNP
rs73855273 174 dbSNP
rs1401443793 175 dbSNP
rs1462703064 180 dbSNP
rs976358433 181 dbSNP
rs77067438 188 dbSNP
rs1278515347 192 dbSNP
rs35166300 193 dbSNP
rs919536186 198 dbSNP
rs1341484131 199 dbSNP
rs138479447 200 dbSNP
rs1249225665 201 dbSNP
rs34267980 202 dbSNP
rs1256661124 205 dbSNP
rs1341071814 208 dbSNP
rs1253917361 210 dbSNP
rs35637163 234 dbSNP
rs772192288 236 dbSNP
rs1324071463 241 dbSNP
rs1347788467 244 dbSNP
rs1174613669 246 dbSNP
rs1212089360 246 dbSNP
rs1469477296 246 dbSNP
rs71133517 246 dbSNP
rs773889020 246 dbSNP
rs796277562 246 dbSNP
rs1430431880 247 dbSNP
rs1201041410 248 dbSNP
rs1232766578 250 dbSNP
rs561583769 250 dbSNP
rs982468952 251 dbSNP
rs1439093312 261 dbSNP
rs1253443143 262 dbSNP
rs76802413 262 dbSNP
rs902419667 263 dbSNP
rs61796377 264 dbSNP
rs113990838 268 dbSNP
rs547312178 278 dbSNP
rs1264222556 280 dbSNP
rs547521865 283 dbSNP
rs1191268194 287 dbSNP
rs34391857 291 dbSNP
rs1337673130 292 dbSNP
rs1032126002 297 dbSNP
rs1334703064 303 dbSNP
rs1452204892 307 dbSNP
rs1379260679 308 dbSNP
rs183889681 315 dbSNP
rs1003216486 316 dbSNP
rs532597703 321 dbSNP
rs796154143 329 dbSNP
rs201377087 332 dbSNP
rs1298405494 333 dbSNP
rs1359520398 341 dbSNP
rs1471437944 346 dbSNP
rs1382861933 347 dbSNP
rs189007860 349 dbSNP
rs983058434 350 dbSNP
rs909793082 351 dbSNP
rs1045645239 356 dbSNP
rs1333276269 358 dbSNP
rs962585701 366 dbSNP
rs1313038287 368 dbSNP
rs903138618 368 dbSNP
rs1245286050 369 dbSNP
rs1383571327 370 dbSNP
rs1234587884 371 dbSNP
rs1428871269 372 dbSNP
rs1345035245 380 dbSNP
rs1319318001 384 dbSNP
rs1274847582 393 dbSNP
rs199752364 393 dbSNP
rs975329896 394 dbSNP
rs1218953864 396 dbSNP
rs55697401 403 dbSNP
rs1444759272 404 dbSNP
rs1488105886 406 dbSNP
rs1214099259 407 dbSNP
rs933994374 408 dbSNP
rs1184472390 418 dbSNP
rs1474875754 423 dbSNP
rs1242500781 427 dbSNP
rs1433621093 433 dbSNP
rs1194999088 435 dbSNP
rs1489848229 436 dbSNP
rs34631097 436 dbSNP
rs571024854 440 dbSNP
rs1051175930 443 dbSNP
rs924713580 447 dbSNP
rs1290996907 448 dbSNP
rs1223102559 454 dbSNP
rs1360327437 463 dbSNP
rs934842537 466 dbSNP
rs1198041014 467 dbSNP
rs1375904491 469 dbSNP
rs1440945998 477 dbSNP
rs1055068819 480 dbSNP
rs1414452594 486 dbSNP
rs531813099 491 dbSNP
rs530282988 492 dbSNP
rs763397203 493 dbSNP
rs1167622174 494 dbSNP
rs536606765 496 dbSNP
rs1007642860 497 dbSNP
rs556685890 499 dbSNP
rs1018145699 503 dbSNP
rs966228802 506 dbSNP
rs1200138800 512 dbSNP
rs1044639349 514 dbSNP
rs765890752 517 dbSNP
rs1248545838 525 dbSNP
rs904854273 527 dbSNP
rs781528821 528 dbSNP
rs1274031278 529 dbSNP
rs1220672177 539 dbSNP
rs1321928248 545 dbSNP
rs1283038950 546 dbSNP
rs1406097267 549 dbSNP
rs1347885373 551 dbSNP
rs1003183834 555 dbSNP
rs1294983426 579 dbSNP
rs1354589067 580 dbSNP
rs1393323277 585 dbSNP
rs868535223 588 dbSNP
rs1467895245 589 dbSNP
rs1387749678 593 dbSNP
rs567300777 600 dbSNP
rs766918508 604 dbSNP
rs1017139424 606 dbSNP
rs1405655268 607 dbSNP
rs1310114054 609 dbSNP
rs1176523199 610 dbSNP
rs1353190785 610 dbSNP
rs1233511189 622 dbSNP
rs1200831526 626 dbSNP
rs77037565 629 dbSNP
rs553263765 635 dbSNP
rs975300506 637 dbSNP
rs1267531333 641 dbSNP
rs573051563 644 dbSNP
rs1305556184 647 dbSNP
rs1223699142 650 dbSNP
rs545243188 651 dbSNP
rs1373510261 653 dbSNP
rs1488679185 658 dbSNP
rs1209039506 661 dbSNP
rs921211650 665 dbSNP
rs955340657 695 dbSNP
rs559055713 698 dbSNP
rs909556482 699 dbSNP
rs1450027787 704 dbSNP
rs1404841772 706 dbSNP
rs1337187384 739 dbSNP
rs962415720 745 dbSNP
rs987245147 745 dbSNP
rs924714545 746 dbSNP
rs991254033 747 dbSNP
rs934709144 754 dbSNP
rs1408815844 764 dbSNP
rs1054550148 765 dbSNP
rs1056195 769 dbSNP
rs1178664004 782 dbSNP
rs1379129485 784 dbSNP
rs1437322881 791 dbSNP
rs1242804641 795 dbSNP
rs1204520676 796 dbSNP
rs915681285 800 dbSNP
rs914720142 806 dbSNP
rs948917539 807 dbSNP
rs575813565 812 dbSNP
rs1243087475 815 dbSNP
rs1381366966 820 dbSNP
rs1458678748 824 dbSNP
rs544766306 825 dbSNP
rs924501112 826 dbSNP
rs934584371 829 dbSNP
rs1392867193 833 dbSNP
rs1054343069 840 dbSNP
rs139845672 844 dbSNP
rs1422873463 846 dbSNP
rs114812547 848 dbSNP
rs1184507549 850 dbSNP
rs1425709299 856 dbSNP
rs540549523 857 dbSNP
rs939020052 859 dbSNP
rs1056500974 861 dbSNP
rs1039104185 862 dbSNP
rs1389810782 873 dbSNP
rs185804815 878 dbSNP
rs1288835715 889 dbSNP
rs1315041889 907 dbSNP
rs1220882747 909 dbSNP
rs886779587 910 dbSNP
rs1358184813 921 dbSNP
rs149804299 931 dbSNP
rs1246539519 959 dbSNP
rs1016695856 967 dbSNP
rs190341434 969 dbSNP
rs1294613659 974 dbSNP
rs182220238 976 dbSNP
rs1382609467 981 dbSNP
rs997672124 1008 dbSNP
rs1271062683 1013 dbSNP
rs1342116505 1037 dbSNP
rs1026498751 1040 dbSNP
rs1301279636 1044 dbSNP
rs950910902 1053 dbSNP
rs1319792325 1055 dbSNP
rs759911268 1056 dbSNP
rs185957995 1064 dbSNP
rs1016568540 1077 dbSNP
rs1183108777 1079 dbSNP
rs1256339100 1085 dbSNP
rs1429536134 1099 dbSNP
rs1265783110 1104 dbSNP
rs1422910077 1109 dbSNP
rs996707216 1110 dbSNP
rs1490310661 1114 dbSNP
rs1211061038 1123 dbSNP
rs1268994423 1123 dbSNP
rs1187217447 1124 dbSNP
rs1337077440 1126 dbSNP
rs1028242633 1128 dbSNP
rs530516750 1138 dbSNP
rs1250460089 1141 dbSNP
rs1416110270 1142 dbSNP
rs1319812584 1145 dbSNP
rs1281060995 1146 dbSNP
rs962399911 1148 dbSNP
rs1346013468 1152 dbSNP
rs986746741 1155 dbSNP
rs1388639809 1158 dbSNP
rs1394399992 1160 dbSNP
rs991593225 1169 dbSNP
rs1467578635 1173 dbSNP
rs1032051994 1174 dbSNP
rs1426240108 1179 dbSNP
rs915646377 1185 dbSNP
rs971566059 1197 dbSNP
rs1201614786 1204 dbSNP
rs1171999625 1212 dbSNP
rs1435627199 1216 dbSNP
rs1400235082 1219 dbSNP
rs924447381 1225 dbSNP
rs981263375 1225 dbSNP
rs934531955 1228 dbSNP
rs1222629767 1237 dbSNP
rs1054292196 1243 dbSNP
rs75057159 1246 dbSNP
rs1395648178 1248 dbSNP
rs990625068 1258 dbSNP
rs1342136374 1263 dbSNP
rs1447817015 1265 dbSNP
rs1219073339 1267 dbSNP
rs1039462676 1276 dbSNP
rs1257279096 1278 dbSNP
rs914680707 1280 dbSNP
rs1469648980 1281 dbSNP
rs567132411 1282 dbSNP
rs1174893927 1294 dbSNP
rs73855274 1297 dbSNP
rs1211563981 1300 dbSNP
rs948884894 1308 dbSNP
rs1178662700 1311 dbSNP
rs16845446 1314 dbSNP
rs1240929212 1318 dbSNP
rs1202619333 1327 dbSNP
rs1461649552 1334 dbSNP
rs1280469429 1343 dbSNP
rs1482669063 1346 dbSNP
rs1203319292 1350 dbSNP
rs1208234866 1352 dbSNP
rs1240918106 1352 dbSNP
rs867166746 1356 dbSNP
rs1478976122 1361 dbSNP
rs938892984 1364 dbSNP
rs1452181492 1367 dbSNP
rs1047993132 1369 dbSNP
rs1336489310 1371 dbSNP
rs1399489162 1383 dbSNP
rs1384820355 1390 dbSNP
rs546548482 1395 dbSNP
rs753219120 1401 dbSNP
rs1421039917 1403 dbSNP
rs1382841789 1404 dbSNP
rs886745801 1420 dbSNP
rs756801851 1430 dbSNP
rs1472884508 1438 dbSNP
rs1327374378 1445 dbSNP
rs1239001666 1448 dbSNP
rs1190702907 1452 dbSNP
rs1178932221 1459 dbSNP
rs1359783788 1463 dbSNP
rs1218680301 1464 dbSNP
rs1356026069 1469 dbSNP
rs1006430924 1472 dbSNP
rs1016514617 1473 dbSNP
rs370261700 1478 dbSNP
rs1357255264 1487 dbSNP
rs373940461 1488 dbSNP
rs375983087 1489 dbSNP
rs566787129 1497 dbSNP
rs939733115 1498 dbSNP
rs1012562554 1500 dbSNP
rs1326187498 1523 dbSNP
rs1299406350 1531 dbSNP
rs1023058935 1533 dbSNP
rs971128988 1534 dbSNP
rs1038108064 1547 dbSNP
rs981151120 1550 dbSNP
rs1352268197 1574 dbSNP
rs1400311530 1587 dbSNP
rs1031416748 1593 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 2960.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000283875.5 | 3UTR | AUCUAAACUUUUUGUGCAAUAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE42095 Differentiated embryonic stem cells 0.584 1.7e-3 0.624 7.3e-4 23 Click to see details
GSE38226 Liver fibrosis -0.388 4.1e-2 -0.136 2.8e-1 21 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.343 4.7e-2 -0.368 3.5e-2 25 Click to see details
GSE32688 Pancreatic cancer 0.236 9.7e-2 0.301 4.7e-2 32 Click to see details
GSE27834 Pluripotent stem cells 0.315 1.2e-1 0.226 2.0e-1 16 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.379 1.8e-1 -0.595 6.0e-2 8 Click to see details
GSE28260 Renal cortex and medulla 0.26 2.0e-1 0.341 1.3e-1 13 Click to see details
GSE14794 Lymphoblastoid cells -0.084 2.2e-1 -0.075 2.4e-1 90 Click to see details
GSE17306 Multiple myeloma 0.102 2.4e-1 0.505 1.1e-4 49 Click to see details
GSE26953 Aortic valvular endothelial cells -0.135 2.6e-1 -0.013 4.8e-1 24 Click to see details
GSE17498 Multiple myeloma -0.074 3.2e-1 -0.054 3.7e-1 40 Click to see details
GSE21687 Ependynoma primary tumors -0.035 3.9e-1 0.008 4.7e-1 64 Click to see details
GSE28544 Breast cancer -0.042 4.2e-1 0.030 4.4e-1 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.027 4.6e-1 -0.338 7.2e-2 20 Click to see details
GSE21849 B cell lymphoma 0.001 5.0e-1 0.044 4.1e-1 29 Click to see details
GSE21849 B cell lymphoma 0.001 5.0e-1 0.044 4.1e-1 29 Click to see details
GSE21849 B cell lymphoma 0.001 5.0e-1 0.044 4.1e-1 29 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
0.001 5.0e-1 0.044 4.1e-1 29 Click to see details
133 hsa-miR-561-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT072097 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 4
MIRT080799 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 4
MIRT088833 MSH6 mutS homolog 6 2 2
MIRT093446 MSMO1 methylsterol monooxygenase 1 2 2
MIRT099908 SOX4 SRY-box 4 2 10
MIRT107568 VLDLR very low density lipoprotein receptor 2 2
MIRT130135 TXNIP thioredoxin interacting protein 2 2
MIRT136944 FNDC3A fibronectin type III domain containing 3A 2 2
MIRT158447 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT161901 FXR1 FMR1 autosomal homolog 1 2 2
MIRT166271 C5ORF51 chromosome 5 open reading frame 51 2 4
MIRT187291 CLIC4 chloride intracellular channel 4 2 4
MIRT202308 CEBPB CCAAT/enhancer binding protein beta 2 2
MIRT210742 PPP4R2 protein phosphatase 4 regulatory subunit 2 2 2
MIRT249020 PABPC3 poly(A) binding protein cytoplasmic 3 2 2
MIRT268845 C1ORF21 chromosome 1 open reading frame 21 2 2
MIRT304688 GTF2E1 general transcription factor IIE subunit 1 2 2
MIRT316774 FOXC1 forkhead box C1 2 2
MIRT325708 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT327970 CHIC1 cysteine rich hydrophobic domain 1 2 6
MIRT328758 DHODH dihydroorotate dehydrogenase (quinone) 2 2
MIRT356391 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT437448 NR0B1 nuclear receptor subfamily 0 group B member 1 1 1
MIRT441383 FRS2 fibroblast growth factor receptor substrate 2 2 2
MIRT442496 PCDH10 protocadherin 10 2 4
MIRT444054 PROX2 prospero homeobox 2 2 2
MIRT446062 RABIF RAB interacting factor 2 2
MIRT446714 FUT10 fucosyltransferase 10 2 2
MIRT456384 CRB1 crumbs 1, cell polarity complex component 2 2
MIRT457022 ACADSB acyl-CoA dehydrogenase, short/branched chain 2 2
MIRT457056 NEGR1 neuronal growth regulator 1 2 2
MIRT457353 RAD51AP1 RAD51 associated protein 1 2 2
MIRT466850 STX6 syntaxin 6 2 2
MIRT471347 PELO pelota mRNA surveillance and ribosome rescue factor 2 2
MIRT474051 LONRF1 LON peptidase N-terminal domain and ring finger 1 2 2
MIRT479058 CNOT6L CCR4-NOT transcription complex subunit 6 like 2 8
MIRT479398 CDKN1B cyclin dependent kinase inhibitor 1B 2 8
MIRT492072 TMED7 transmembrane p24 trafficking protein 7 2 2
MIRT492810 PCBP1 poly(rC) binding protein 1 2 6
MIRT494861 ZNF99 zinc finger protein 99 2 2
MIRT496888 TMTC2 transmembrane and tetratricopeptide repeat containing 2 2 2
MIRT498041 TAOK1 TAO kinase 1 2 2
MIRT500856 SYPL1 synaptophysin like 1 2 8
MIRT501323 RNFT1 ring finger protein, transmembrane 1 2 2
MIRT502795 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 6
MIRT503684 SLC46A1 solute carrier family 46 member 1 2 2
MIRT506383 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT507320 FAM60A SIN3-HDAC complex associated factor 2 6
MIRT507671 CPEB4 cytoplasmic polyadenylation element binding protein 4 2 4
MIRT510809 SENP3 SUMO1/sentrin/SMT3 specific peptidase 3 2 8
MIRT512260 ARPP19 cAMP regulated phosphoprotein 19 2 6
MIRT514215 LRRC63 leucine rich repeat containing 63 2 2
MIRT517729 NT5DC1 5'-nucleotidase domain containing 1 2 4
MIRT520570 TMF1 TATA element modulatory factor 1 2 2
MIRT523456 GPBP1L1 GC-rich promoter binding protein 1 like 1 2 6
MIRT524538 CDCA4 cell division cycle associated 4 2 2
MIRT525478 SPIC Spi-C transcription factor 2 2
MIRT532321 GHSR growth hormone secretagogue receptor 2 2
MIRT534716 RFX7 regulatory factor X7 2 2
MIRT535042 PRKAA1 protein kinase AMP-activated catalytic subunit alpha 1 2 2
MIRT535111 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT536665 INIP INTS3 and NABP interacting protein 2 2
MIRT537636 ERGIC2 ERGIC and golgi 2 2 2
MIRT537701 ELOVL6 ELOVL fatty acid elongase 6 2 2
MIRT538060 DMD dystrophin 2 4
MIRT538811 C21orf91 chromosome 21 open reading frame 91 2 2
MIRT539270 ANKRD28 ankyrin repeat domain 28 2 2
MIRT541158 PABPC1 poly(A) binding protein cytoplasmic 1 2 2
MIRT543500 MDM2 MDM2 proto-oncogene 2 4
MIRT545101 TRIM66 tripartite motif containing 66 2 2
MIRT545328 SLC7A5P2 solute carrier family 7 member 5 pseudogene 2 2 2
MIRT545838 ZNF275 zinc finger protein 275 2 2
MIRT546109 USP48 ubiquitin specific peptidase 48 2 4
MIRT548100 GFPT1 glutamine--fructose-6-phosphate transaminase 1 2 4
MIRT549216 BCLAF1 BCL2 associated transcription factor 1 2 4
MIRT549705 RBM23 RNA binding motif protein 23 2 4
MIRT550139 ZNF138 zinc finger protein 138 2 2
MIRT551104 TTC8 tetratricopeptide repeat domain 8 2 2
MIRT551212 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT551389 ZNF543 zinc finger protein 543 2 4
MIRT553330 TSC22D2 TSC22 domain family member 2 2 2
MIRT553885 SUPT7L SPT7 like, STAGA complex gamma subunit 2 4
MIRT554651 ROBO1 roundabout guidance receptor 1 2 2
MIRT554879 RCAN2 regulator of calcineurin 2 2 2
MIRT555602 PIP4K2C phosphatidylinositol-5-phosphate 4-kinase type 2 gamma 2 2
MIRT556467 LMNB2 lamin B2 2 4
MIRT557838 FNBP1L formin binding protein 1 like 2 2
MIRT558143 ENC1 ectodermal-neural cortex 1 2 2
MIRT558754 CHERP calcium homeostasis endoplasmic reticulum protein 2 2
MIRT560530 TMEM98 transmembrane protein 98 2 2
MIRT561068 EIF4A3 eukaryotic translation initiation factor 4A3 2 2
MIRT561384 TWF1 twinfilin actin binding protein 1 2 2
MIRT561460 TEAD1 TEA domain transcription factor 1 2 2
MIRT561818 NUP155 nucleoporin 155 2 2
MIRT561963 LSM12 LSM12 homolog 2 2
MIRT562183 HNRNPF heterogeneous nuclear ribonucleoprotein F 2 2
MIRT564363 PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2 2
MIRT564470 SLC35E2 solute carrier family 35 member E2 2 2
MIRT564755 ZNF146 zinc finger protein 146 2 2
MIRT565532 SON SON DNA binding protein 2 2
MIRT565744 SESN3 sestrin 3 2 2
MIRT566236 PTCH1 patched 1 2 2
MIRT568636 ACVR2A activin A receptor type 2A 2 2
MIRT571081 TCHHL1 trichohyalin like 1 2 2
MIRT571559 YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta 2 2
MIRT572246 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT572908 RUNDC3B RUN domain containing 3B 2 2
MIRT573201 TTC19 tetratricopeptide repeat domain 19 2 2
MIRT573981 DDX21 DExD-box helicase 21 2 2
MIRT614493 LIX1 limb and CNS expressed 1 2 2
MIRT614579 TMTC1 transmembrane and tetratricopeptide repeat containing 1 2 2
MIRT614898 PAPOLG poly(A) polymerase gamma 2 2
MIRT615469 BNC2 basonuclin 2 2 2
MIRT617968 ZNF713 zinc finger protein 713 2 2
MIRT620418 TFDP3 transcription factor Dp family member 3 2 2
MIRT623571 ISL1 ISL LIM homeobox 1 2 2
MIRT624902 USP6NL USP6 N-terminal like 2 2
MIRT625346 TAPBP TAP binding protein 2 2
MIRT628309 CNN3 calponin 3 2 2
MIRT630979 ARL4C ADP ribosylation factor like GTPase 4C 2 2
MIRT637274 KLHL12 kelch like family member 12 2 2
MIRT643959 GALNT13 polypeptide N-acetylgalactosaminyltransferase 13 2 2
MIRT649795 LPCAT3 lysophosphatidylcholine acyltransferase 3 2 2
MIRT653573 SLC35B3 solute carrier family 35 member B3 2 2
MIRT653997 SCYL3 SCY1 like pseudokinase 3 2 2
MIRT654011 SCO1 SCO1, cytochrome c oxidase assembly protein 2 2
MIRT658530 ERP44 endoplasmic reticulum protein 44 2 2
MIRT683755 C3orf36 chromosome 3 open reading frame 36 2 2
MIRT690907 TOP2A DNA topoisomerase II alpha 2 2
MIRT697689 WASL Wiskott-Aldrich syndrome like 2 2
MIRT698820 STK38 serine/threonine kinase 38 2 2
MIRT701625 MYO1B myosin IB 2 2
MIRT712319 PER2 period circadian clock 2 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-561 Glucose NULL 5793 Microarray endothelial cells 24394957 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-561-3p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (HT-29)
hsa-miR-561-3p Trametinib 11707110 NSC758246 approved sensitive High Melanoma cell line (WM266) (200nM)
hsa-miR-561-3p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (WM266) (200nM)
hsa-miR-561-3p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-561-3p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-561-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-561-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-561-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-561-3p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-561-3p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-561-3p Pegylated interferon alpha+Ribavirin resistant tissue (chronic hepatitis C)
hsa-miR-561-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-561-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-561-3p Cisplatin 5460033 NSC119875 approved resistant cell line (H460)
hsa-miR-561-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)
hsa-miR-561-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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