miRTarBase - #MIRT307053


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pre-miRNA Information
pre-miRNA hsa-mir-449b   
Genomic Coordinates chr5: 55170646 - 55170742
Description Homo sapiens miR-449b stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-449b-5p
Sequence 16| AGGCAGUGUAUUGUUAGCUGGC |37
Evidence Experimental
Experiments Microarray
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN8871076 12 COSMIC
COSN17153496 22 COSMIC
COSN31576772 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1322925717 3 dbSNP
rs769526811 10 dbSNP
rs10061133 12 dbSNP
rs1431829587 13 dbSNP
rs778042202 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TGFBR2   
Synonyms AAT3, FAA3, LDS1B, LDS2, LDS2B, MFS2, RIIC, TAAD2, TGFR-2, TGFbeta-RII
Description transforming growth factor beta receptor 2
Transcript NM_001024847   
Other Transcripts NM_003242   
Expression
Putative miRNA Targets on TGFBR2
3'UTR of TGFBR2
(miRNA target sites are highlighted)		 
>TGFBR2|NM_001024847|3'UTR
   1 CTCTTCTGGGGCAGGCTGGGCCATGTCCAAAGAGGCTGCCCCTCTCACCAAAGAACAGAGGCAGCAGGAAGCTGCCCCTG
  81 AACTGATGCTTCCTGGAAAACCAAGGGGGTCACTCCCCTCCCTGTAAGCTGTGGGGATAAGCAGAAACAACAGCAGCAGG
 161 GAGTGGGTGACATAGAGCATTCTATGCCTTTGACATTGTCATAGGATAAGCTGTGTTAGCACTTCCTCAGGAAATGAGAT
 241 TGATTTTTACAATAGCCAATAACATTTGCACTTTATTAATGCCTGTATATAAATATGAATAGCTATGTTTTATATATATA
 321 TATATATATCTATATATGTCTATAGCTCTATATATATAGCCATACCTTGAAAAGAGACAAGGAAAAACATCAAATATTCC
 401 CAGGAAATTGGTTTTATTGGAGAACTCCAGAACCAAGCAGAGAAGGAAGGGACCCATGACAGCATTAGCATTTGACAATC
 481 ACACATGCAGTGGTTCTCTGACTGTAAAACAGTGAACTTTGCATGAGGAAAGAGGCTCCATGTCTCACAGCCAGCTATGA
 561 CCACATTGCACTTGCTTTTGCAAAATAATCATTCCCTGCCTAGCACTTCTCTTCTGGCCATGGAACTAAGTACAGTGGCA
 641 CTGTTTGAGGACCAGTGTTCCCGGGGTTCCTGTGTGCCCTTATTTCTCCTGGACTTTTCATTTAAGCTCCAAGCCCCAAA
 721 TCTGGGGGGCTAGTTTAGAAACTCTCCCTCAACCTAGTTTAGAAACTCTACCCCATCTTTAATACCTTGAATGTTTTGAA
 801 CCCCACTTTTTACCTTCATGGGTTGCAGAAAAATCAGAACAGATGTCCCCATCCATGCGATTGCCCCACCATCTACTAAT
 881 GAAAAATTGTTCTTTTTTTCATCTTTCCCCTGCACTTATGTTACTATTCTCTGCTCCCAGCCTTCATCCTTTTCTAAAAA
 961 GGAGCAAATTCTCACTCTAGGCTTTATCGTGTTTACTTTTTCATTACACTTGACTTGATTTTCTAGTTTTCTATACAAAC
1041 ACCAATGGGTTCCATCTTTCTGGGCTCCTGATTGCTCAAGCACAGTTTGGCCTGATGAAGAGGATTTCAACTACACAATA
1121 CTATCATTGTCAGGACTATGACCTCAGGCACTCTAAACATATGTTTTGTTTGGTCAGCACAGCGTTTCAAAAAGTGAAGC
1201 CACTTTATAAATATTTGGAGATTTTGCAGGAAAATCTGGATCCCCAGGTAAGGATAGCAGATGGTTTTCAGTTATCTCCA
1281 GTCCACGTTCACAAAATGTGAAGGTGTGGAGACACTTACAAAGCTGCCTCACTTCTCACTGTAAACATTAGCTCTTTCCA
1361 CTGCCTACCTGGACCCCAGTCTAGGAATTAAATCTGCACCTAACCAAGGTCCCTTGTAAGAAATGTCCATTCAAGCAGTC
1441 ATTCTCTGGGTATATAATATGATTTTGACTACCTTATCTGGTGTTAAGATTTGAAGTTGGCCTTTTATTGGACTAAAGGG
1521 GAACTCCTTTAAGGGTCTCAGTTAGCCCAAGTTTCTTTTGCTTATATGTTAATAGTTTTACCCTCTGCATTGGAGAGAGG
1601 AGTGCTTTACTCCAAGAAGCTTTCCTCATGGTTACCGTTCTCTCCATCATGCCAGCCTTCTCAACCTTTGCAGAAATTAC
1681 TAGAGAGGATTTGAATGTGGGACACAAAGGTCCCATTTGCAGTTAGAAAATTTGTGTCCACAAGGACAAGAACAAAGTAT
1761 GAGCTTTAAAACTCCATAGGAAACTTGTTAATCAACAAAGAAGTGTTAATGCTGCAAGTAATCTCTTTTTTAAAACTTTT
1841 TGAAGCTACTTATTTTCAGCCAAATAGGAATATTAGAGAGGGACTGGTAGTGAGAATATCAGCTCTGTTTGGATGGTGGA
1921 AGGTCTCATTTTATTGAGATTTTTAAGATACATGCAAAGGTTTGGAAATAGAACCTCTAGGCACCCTCCTCAGTGTGGGT
2001 GGGCTGAGAGTTAAAGACAGTGTGGCTGCAGTAGCATAGAGGCGCCTAGAAATTCCACTTGCACCGTAGGGCATGCTGAT
2081 ACCATCCCAATAGCTGTTGCCCATTGACCTCTAGTGGTGAGTTTCTAGAATACTGGTCCATTCATGAGATATTCAAGATT
2161 CAAGAGTATTCTCACTTCTGGGTTATCAGCATAAACTGGAATGTAGTGTCAGAGGATACTGTGGCTTGTTTTGTTTATGT
2241 TTTTTTTTCTTATTCAAGAAAAAAGACCAAGGAATAACATTCTGTAGTTCCTAAAAATACTGACTTTTTTCACTACTATA
2321 CATAAAGGGAAAGTTTTATTCTTTTATGGAACACTTCAGCTGTACTCATGTATTAAAATAGGAATGTGAATGCTATATAC
2401 TCTTTTTATATCAAAAGTCTCAAGCACTTATTTTTATTCTATGCATTGTTTGTCTTTTACATAAATAAAATGTTTATTAG
2481 ATTGAATAAAGCAAAATACTCAGGTGAGCATCCTGCCTCCTGTTCCCATTCCTAGTAGCTAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgGUCGAUUGUUAUGUGACGGa 5'
            :||||  |  | ||||||| 
Target 5' atTAGCT--CTTTCCACTGCCt 3'
 1347 - 1366 152.00 -16.50
2 
miRNA  3' cgGUCGAU-UGUUAU----GUGACGGa 5'
            || ||| ||||||    ||:||:| 
Target 5' ttCAACTACACAATACTATCATTGTCa 3'
 1106 - 1132 138.00 -12.10
3 
miRNA  3' cgGUCGAUUGUUAUGUGACGga 5'
            ||||||  |  |||:|||  
Target 5' gcCAGCTATGACCACATTGCac 3'
 550 - 571 132.00 -20.00
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
259009 12 ClinVar
344664 34 ClinVar
344665 87 ClinVar
344666 106 ClinVar
344667 150 ClinVar
344668 227 ClinVar
1183809 311 ClinVar
344669 311 ClinVar
344670 313 ClinVar
344671 329 ClinVar
344672 329 ClinVar
344673 331 ClinVar
344674 353 ClinVar
901441 408 ClinVar
344675 444 ClinVar
902006 580 ClinVar
344676 599 ClinVar
344677 600 ClinVar
344678 705 ClinVar
344679 714 ClinVar
344680 743 ClinVar
344681 748 ClinVar
344682 794 ClinVar
344683 800 ClinVar
902007 821 ClinVar
344684 836 ClinVar
344685 849 ClinVar
344686 859 ClinVar
344687 860 ClinVar
344688 989 ClinVar
344689 990 ClinVar
344690 998 ClinVar
344691 1076 ClinVar
344692 1202 ClinVar
900344 1208 ClinVar
344693 1212 ClinVar
344694 1286 ClinVar
344695 1327 ClinVar
900345 1328 ClinVar
344696 1355 ClinVar
900346 1466 ClinVar
344697 1508 ClinVar
344698 1522 ClinVar
344699 1573 ClinVar
901497 1638 ClinVar
344700 1683 ClinVar
901498 1716 ClinVar
344701 1810 ClinVar
344702 1816 ClinVar
344703 1834 ClinVar
344704 1843 ClinVar
344705 1860 ClinVar
344706 1861 ClinVar
344707 1881 ClinVar
344708 1887 ClinVar
344709 1888 ClinVar
902068 1888 ClinVar
902069 1967 ClinVar
344710 1999 ClinVar
344711 2066 ClinVar
344712 2067 ClinVar
344713 2086 ClinVar
344714 2240 ClinVar
344715 2333 ClinVar
344716 2336 ClinVar
344717 2341 ClinVar
344718 2426 ClinVar
344719 2438 ClinVar
344720 2484 ClinVar
COSN31601365 42 COSMIC
COSN30526414 43 COSMIC
COSN30165984 59 COSMIC
COSN30181787 75 COSMIC
COSN30110402 98 COSMIC
COSN31519549 171 COSMIC
COSN1945906 202 COSMIC
COSN31546612 293 COSMIC
COSN31592766 309 COSMIC
COSN23283953 312 COSMIC
COSN20098257 329 COSMIC
COSN30175187 562 COSMIC
COSN6426623 683 COSMIC
COSN22421885 1057 COSMIC
COSN20170328 1263 COSMIC
COSN15839801 1288 COSMIC
COSN22517147 1453 COSMIC
COSN20739924 1539 COSMIC
COSN30109943 1555 COSMIC
COSN8489100 1628 COSMIC
COSN19412090 1630 COSMIC
COSN21432166 1748 COSMIC
COSN22416830 1749 COSMIC
COSN26465751 1754 COSMIC
COSN26640732 1797 COSMIC
COSN9547763 1801 COSMIC
COSN31484301 1826 COSMIC
COSN16606138 2007 COSMIC
COSN15660001 2009 COSMIC
COSN7605636 2017 COSMIC
COSN23849468 2057 COSMIC
COSN31527781 2157 COSMIC
COSN31540640 2190 COSMIC
COSN20098258 2249 COSMIC
COSN32064864 2250 COSMIC
COSN14847545 2273 COSMIC
COSN14461379 2301 COSMIC
COSN23271800 2376 COSMIC
COSN29671635 2385 COSMIC
COSN31601219 2436 COSMIC
COSN31543940 2469 COSMIC
rs6550008 1810 GWAS
rs542768261 2241 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1017849203 6 dbSNP
rs1273676501 9 dbSNP
rs766751602 11 dbSNP
rs886038529 12 dbSNP
rs374127951 21 dbSNP
rs760055355 24 dbSNP
rs767870504 25 dbSNP
rs752848507 26 dbSNP
rs1235230055 30 dbSNP
rs1472143868 31 dbSNP
rs369578953 33 dbSNP
rs886058306 34 dbSNP
rs1463497403 35 dbSNP
rs1157368447 38 dbSNP
rs778145481 39 dbSNP
rs1421581888 40 dbSNP
rs1382990356 42 dbSNP
rs754109749 43 dbSNP
rs758188328 49 dbSNP
rs945172116 51 dbSNP
rs1294004676 53 dbSNP
rs1416259010 60 dbSNP
rs558371189 63 dbSNP
rs976284576 70 dbSNP
rs376307349 76 dbSNP
rs1173248670 77 dbSNP
rs1043691434 84 dbSNP
rs1236170528 85 dbSNP
rs1355612472 86 dbSNP
rs540602629 87 dbSNP
rs1286155859 90 dbSNP
rs1215409729 101 dbSNP
rs565436114 102 dbSNP
rs149112005 106 dbSNP
rs554379684 110 dbSNP
rs1277743975 119 dbSNP
rs909244919 121 dbSNP
rs574343493 132 dbSNP
rs1216101880 135 dbSNP
rs1296276769 137 dbSNP
rs772416591 146 dbSNP
rs1311508550 148 dbSNP
rs143024112 150 dbSNP
rs1038733315 152 dbSNP
rs1037221349 153 dbSNP
rs1417973672 161 dbSNP
rs1351765692 165 dbSNP
rs1165766168 166 dbSNP
rs1215460305 167 dbSNP
rs1405127060 170 dbSNP
rs556791298 172 dbSNP
rs905112714 173 dbSNP
rs1173417122 183 dbSNP
rs776094473 186 dbSNP
rs1263126523 193 dbSNP
rs1056315374 204 dbSNP
rs896297308 206 dbSNP
rs995619926 212 dbSNP
rs1248084651 214 dbSNP
rs1433150728 215 dbSNP
rs1009344028 216 dbSNP
rs201873824 216 dbSNP
rs1221938269 221 dbSNP
rs886058307 227 dbSNP
rs1320860965 243 dbSNP
rs113220101 251 dbSNP
rs1174519731 255 dbSNP
rs17026326 266 dbSNP
rs1435344463 284 dbSNP
rs1020704109 286 dbSNP
rs1027228579 290 dbSNP
rs1318461187 298 dbSNP
rs1277494150 303 dbSNP
rs903556065 306 dbSNP
rs1369893015 308 dbSNP
rs199931498 308 dbSNP
rs1426714901 311 dbSNP
rs1436075056 311 dbSNP
rs35934901 311 dbSNP
rs4016180 311 dbSNP
rs749731499 311 dbSNP
rs750106981 311 dbSNP
rs886058308 311 dbSNP
rs890034029 311 dbSNP
rs1289198186 312 dbSNP
rs576840706 313 dbSNP
rs1385028052 314 dbSNP
rs1487927672 315 dbSNP
rs1017654012 319 dbSNP
rs1250787537 323 dbSNP
rs1382273221 323 dbSNP
rs1257331121 325 dbSNP
rs965002821 326 dbSNP
rs1017659107 327 dbSNP
rs965840165 327 dbSNP
rs998152788 327 dbSNP
rs1491341550 329 dbSNP
rs561991238 329 dbSNP
rs886058309 329 dbSNP
rs886058310 329 dbSNP
rs304840 331 dbSNP
rs1348064369 333 dbSNP
rs983532577 335 dbSNP
rs1400116250 343 dbSNP
rs1296928894 346 dbSNP
rs909297012 347 dbSNP
rs780253858 349 dbSNP
rs963393357 351 dbSNP
rs565524213 353 dbSNP
rs927259280 361 dbSNP
rs1180186744 370 dbSNP
rs1440071411 371 dbSNP
rs937964183 375 dbSNP
rs527890008 377 dbSNP
rs1056766659 386 dbSNP
rs1193981725 394 dbSNP
rs1484165485 396 dbSNP
rs1243082510 403 dbSNP
rs1256545979 405 dbSNP
rs917786105 408 dbSNP
rs990851603 409 dbSNP
rs1189989804 416 dbSNP
rs1255435138 418 dbSNP
rs917889748 428 dbSNP
rs188599299 444 dbSNP
rs1398189846 452 dbSNP
rs1158099129 475 dbSNP
rs1380445714 477 dbSNP
rs1042201572 481 dbSNP
rs1037553607 496 dbSNP
rs903611689 497 dbSNP
rs1433548593 499 dbSNP
rs1000994012 503 dbSNP
rs1038715133 513 dbSNP
rs575460370 522 dbSNP
rs900146685 525 dbSNP
rs1419982072 529 dbSNP
rs997804974 532 dbSNP
rs1179342811 535 dbSNP
rs764512230 537 dbSNP
rs1256696847 539 dbSNP
rs1160041326 558 dbSNP
rs950923306 560 dbSNP
rs193049270 566 dbSNP
rs1005011226 567 dbSNP
rs1217469342 573 dbSNP
rs1353211321 576 dbSNP
rs1259191128 580 dbSNP
rs1349101904 583 dbSNP
rs886058311 599 dbSNP
rs79755385 600 dbSNP
rs1322759911 601 dbSNP
rs1327912822 607 dbSNP
rs1371614435 611 dbSNP
rs754062251 612 dbSNP
rs1352996790 621 dbSNP
rs980573016 634 dbSNP
rs927339769 638 dbSNP
rs890048815 639 dbSNP
rs1156455741 642 dbSNP
rs1007072634 644 dbSNP
rs960301166 647 dbSNP
rs1368902572 661 dbSNP
rs1474158650 662 dbSNP
rs992123682 663 dbSNP
rs1194395744 664 dbSNP
rs1259898822 667 dbSNP
rs1445454096 673 dbSNP
rs1211927662 687 dbSNP
rs886058312 705 dbSNP
rs886058313 714 dbSNP
rs1374819109 715 dbSNP
rs1224009729 719 dbSNP
rs1231868151 725 dbSNP
rs1320570153 727 dbSNP
rs1279389482 730 dbSNP
rs17026328 743 dbSNP
rs1325401533 744 dbSNP
rs11466531 748 dbSNP
rs1042256388 749 dbSNP
rs1324929639 751 dbSNP
rs1021161029 754 dbSNP
rs966409227 765 dbSNP
rs1275649625 766 dbSNP
rs925082009 767 dbSNP
rs1475123341 773 dbSNP
rs1371449572 784 dbSNP
rs532320111 788 dbSNP
rs936455098 789 dbSNP
rs1201251257 793 dbSNP
rs886058314 794 dbSNP
rs1452354210 795 dbSNP
rs886058315 800 dbSNP
rs1039181102 805 dbSNP
rs542944964 819 dbSNP
rs765340266 820 dbSNP
rs1259248325 821 dbSNP
rs997588634 830 dbSNP
rs979265792 835 dbSNP
rs17026332 836 dbSNP
rs959297507 838 dbSNP
rs1234827645 840 dbSNP
rs1178000235 845 dbSNP
rs1302255055 847 dbSNP
rs1438428734 847 dbSNP
rs991169798 848 dbSNP
rs17026336 849 dbSNP
rs1403447589 851 dbSNP
rs142745018 859 dbSNP
rs548242538 860 dbSNP
rs568093577 876 dbSNP
rs111802426 882 dbSNP
rs1001658526 884 dbSNP
rs1192048718 886 dbSNP
rs537031470 894 dbSNP
rs779977871 908 dbSNP
rs557034249 909 dbSNP
rs1204299109 911 dbSNP
rs1281356736 913 dbSNP
rs1442298452 914 dbSNP
rs1201618359 917 dbSNP
rs1348053486 920 dbSNP
rs751447751 928 dbSNP
rs992832388 932 dbSNP
rs1378809632 933 dbSNP
rs1309651142 936 dbSNP
rs574969117 938 dbSNP
rs1333840790 943 dbSNP
rs942868862 944 dbSNP
rs1041727498 948 dbSNP
rs754796336 962 dbSNP
rs781028203 963 dbSNP
rs901420546 974 dbSNP
rs1171971413 976 dbSNP
rs1376487813 977 dbSNP
rs1020265876 978 dbSNP
rs1042019589 980 dbSNP
rs1295529732 980 dbSNP
rs1468939326 982 dbSNP
rs1335847197 987 dbSNP
rs138036906 989 dbSNP
rs886058316 990 dbSNP
rs1256253084 991 dbSNP
rs886058317 998 dbSNP
rs977982781 1004 dbSNP
rs141927808 1008 dbSNP
rs936493503 1009 dbSNP
rs1348343686 1010 dbSNP
rs1285873162 1018 dbSNP
rs974557787 1031 dbSNP
rs1415363637 1034 dbSNP
rs1474367330 1039 dbSNP
rs921679311 1043 dbSNP
rs933052167 1046 dbSNP
rs1311106061 1055 dbSNP
rs1418327700 1060 dbSNP
rs867518387 1061 dbSNP
rs1032078778 1064 dbSNP
rs959222979 1066 dbSNP
rs1158733102 1068 dbSNP
rs544093849 1076 dbSNP
rs1416463639 1077 dbSNP
rs1168533588 1078 dbSNP
rs886083788 1079 dbSNP
rs540744767 1091 dbSNP
rs1256059326 1097 dbSNP
rs541755564 1109 dbSNP
rs1332891230 1118 dbSNP
rs1242325002 1122 dbSNP
rs551488937 1130 dbSNP
rs1356889948 1139 dbSNP
rs1445031813 1142 dbSNP
rs541286856 1145 dbSNP
rs185269441 1151 dbSNP
rs1233695540 1156 dbSNP
rs1313046852 1159 dbSNP
rs918563043 1160 dbSNP
rs1291381846 1169 dbSNP
rs1220533514 1173 dbSNP
rs1362834208 1174 dbSNP
rs1288480049 1175 dbSNP
rs1428947626 1181 dbSNP
rs1351860877 1182 dbSNP
rs1324571889 1184 dbSNP
rs34773126 1189 dbSNP
rs899367726 1194 dbSNP
rs1416255031 1197 dbSNP
rs1002109310 1199 dbSNP
rs1173524596 1202 dbSNP
rs886058318 1202 dbSNP
rs886058319 1212 dbSNP
rs373324838 1229 dbSNP
rs952695730 1235 dbSNP
rs1419656205 1236 dbSNP
rs1185546988 1238 dbSNP
rs1268983739 1249 dbSNP
rs984198290 1253 dbSNP
rs1034485069 1258 dbSNP
rs1214031933 1261 dbSNP
rs1467916540 1263 dbSNP
rs1342051112 1270 dbSNP
rs1271195654 1271 dbSNP
rs1215627401 1282 dbSNP
rs1200496795 1283 dbSNP
rs574876197 1286 dbSNP
rs1014322955 1288 dbSNP
rs1020318200 1299 dbSNP
rs967356648 1301 dbSNP
rs879215063 1304 dbSNP
rs922851130 1305 dbSNP
rs1304457242 1307 dbSNP
rs1440612851 1313 dbSNP
rs376278596 1318 dbSNP
rs886058320 1327 dbSNP
rs1333912666 1332 dbSNP
rs978036900 1336 dbSNP
rs866188301 1346 dbSNP
rs747808681 1347 dbSNP
rs11466532 1355 dbSNP
rs902207012 1358 dbSNP
rs974988203 1363 dbSNP
rs921759545 1364 dbSNP
rs933084545 1370 dbSNP
rs1250962239 1373 dbSNP
rs894893271 1376 dbSNP
rs1012497805 1389 dbSNP
rs1250693828 1410 dbSNP
rs563297176 1416 dbSNP
rs150669594 1417 dbSNP
rs1202453218 1425 dbSNP
rs987164326 1426 dbSNP
rs1314079227 1428 dbSNP
rs552020910 1433 dbSNP
rs940356068 1434 dbSNP
rs1475716513 1441 dbSNP
rs1233891087 1454 dbSNP
rs1024775756 1455 dbSNP
rs1171877784 1466 dbSNP
rs1311850364 1472 dbSNP
rs1392739252 1474 dbSNP
rs1392363445 1492 dbSNP
rs1373171568 1502 dbSNP
rs139938413 1508 dbSNP
rs994121914 1510 dbSNP
rs1376792015 1519 dbSNP
rs11466533 1522 dbSNP
rs937576400 1531 dbSNP
rs952747946 1534 dbSNP
rs1056384284 1540 dbSNP
rs571220771 1540 dbSNP
rs984082460 1543 dbSNP
rs911308054 1546 dbSNP
rs1249713417 1556 dbSNP
rs1359483050 1558 dbSNP
rs190586104 1563 dbSNP
rs866542579 1565 dbSNP
rs182312262 1569 dbSNP
rs878857301 1573 dbSNP
rs1345942265 1574 dbSNP
rs1288428070 1583 dbSNP
rs1041813805 1600 dbSNP
rs1328517121 1601 dbSNP
rs774680263 1616 dbSNP
rs903224403 1617 dbSNP
rs1274715348 1621 dbSNP
rs1316769884 1629 dbSNP
rs1305458601 1636 dbSNP
rs536790333 1637 dbSNP
rs1032978663 1638 dbSNP
rs1312914155 1645 dbSNP
rs550697408 1648 dbSNP
rs1413636495 1661 dbSNP
rs1373180375 1665 dbSNP
rs1159998029 1666 dbSNP
rs1236573891 1670 dbSNP
rs1363051737 1672 dbSNP
rs17026341 1683 dbSNP
rs1353217114 1689 dbSNP
rs1050836 1690 dbSNP
rs1476116737 1698 dbSNP
rs1418524269 1699 dbSNP
rs1203569812 1703 dbSNP
rs1187225034 1704 dbSNP
rs770496087 1708 dbSNP
rs149862574 1710 dbSNP
rs559265897 1716 dbSNP
rs1205991648 1717 dbSNP
rs1485736021 1721 dbSNP
rs1259281525 1730 dbSNP
rs954532812 1735 dbSNP
rs185309141 1747 dbSNP
rs1336018590 1753 dbSNP
rs907629929 1760 dbSNP
rs1232135038 1777 dbSNP
rs1353095204 1780 dbSNP
rs372437429 1788 dbSNP
rs1251056880 1798 dbSNP
rs1319846088 1803 dbSNP
rs1383813475 1810 dbSNP
rs6550008 1810 dbSNP
rs1173683305 1815 dbSNP
rs146296952 1816 dbSNP
rs936363058 1824 dbSNP
rs1164211094 1826 dbSNP
rs1474251185 1827 dbSNP
rs1374914104 1832 dbSNP
rs1803446 1834 dbSNP
rs1428100949 1837 dbSNP
rs894897412 1838 dbSNP
rs886058321 1843 dbSNP
rs1215883358 1857 dbSNP
rs886058322 1860 dbSNP
rs886058323 1861 dbSNP
rs1469234511 1869 dbSNP
rs1273100962 1880 dbSNP
rs11466534 1881 dbSNP
rs11466535 1887 dbSNP
rs886058324 1888 dbSNP
rs1227555053 1891 dbSNP
rs1325418848 1892 dbSNP
rs576800011 1898 dbSNP
rs17026348 1899 dbSNP
rs1443242623 1902 dbSNP
rs1325117086 1906 dbSNP
rs1459768701 1917 dbSNP
rs993952963 1922 dbSNP
rs1025554558 1923 dbSNP
rs1376185486 1939 dbSNP
rs1371544752 1949 dbSNP
rs1237167960 1950 dbSNP
rs950194562 1953 dbSNP
rs1041868350 1958 dbSNP
rs888322380 1961 dbSNP
rs1192174415 1968 dbSNP
rs1440017875 1981 dbSNP
rs1274324019 1986 dbSNP
rs188109487 1988 dbSNP
rs1338244861 1993 dbSNP
rs886058325 1999 dbSNP
rs777022596 2001 dbSNP
rs1018198794 2007 dbSNP
rs1054883228 2022 dbSNP
rs1371311512 2037 dbSNP
rs964492654 2038 dbSNP
rs1438448248 2039 dbSNP
rs899813691 2040 dbSNP
rs762042637 2041 dbSNP
rs1030149854 2042 dbSNP
rs528412925 2043 dbSNP
rs967607035 2044 dbSNP
rs548360294 2045 dbSNP
rs996525456 2046 dbSNP
rs1028902817 2053 dbSNP
rs1394468788 2065 dbSNP
rs11466536 2066 dbSNP
rs566913021 2067 dbSNP
rs989159795 2068 dbSNP
rs916225952 2069 dbSNP
rs1233949972 2072 dbSNP
rs1181771449 2077 dbSNP
rs947696985 2078 dbSNP
rs11466537 2086 dbSNP
rs906272430 2091 dbSNP
rs961784109 2102 dbSNP
rs766443493 2103 dbSNP
rs1352658250 2109 dbSNP
rs1392682105 2110 dbSNP
rs1238302126 2113 dbSNP
rs1463492930 2115 dbSNP
rs1327092064 2121 dbSNP
rs1415476347 2129 dbSNP
rs1375011102 2137 dbSNP
rs929813701 2139 dbSNP
rs1402800046 2149 dbSNP
rs751511142 2149 dbSNP
rs1409241542 2152 dbSNP
rs920282415 2156 dbSNP
rs1420663490 2158 dbSNP
rs1469022053 2158 dbSNP
rs1309497431 2159 dbSNP
rs1336553819 2164 dbSNP
rs1244285266 2172 dbSNP
rs1207638375 2174 dbSNP
rs1448494049 2175 dbSNP
rs1284630521 2181 dbSNP
rs913407470 2229 dbSNP
rs947525889 2234 dbSNP
rs1223028884 2236 dbSNP
rs1043304936 2238 dbSNP
rs1336606092 2239 dbSNP
rs1164391055 2240 dbSNP
rs1282623826 2240 dbSNP
rs1358456459 2240 dbSNP
rs34914516 2240 dbSNP
rs888374612 2248 dbSNP
rs900737881 2250 dbSNP
rs1257342936 2253 dbSNP
rs570583391 2255 dbSNP
rs1479406829 2256 dbSNP
rs1317994448 2262 dbSNP
rs1399340455 2271 dbSNP
rs958389514 2272 dbSNP
rs992187885 2283 dbSNP
rs1197015190 2289 dbSNP
rs1166377802 2291 dbSNP
rs1475232883 2294 dbSNP
rs917507797 2300 dbSNP
rs1416587256 2311 dbSNP
rs11556633 2317 dbSNP
rs865849202 2319 dbSNP
rs886058326 2333 dbSNP
rs1207921070 2334 dbSNP
rs886058327 2336 dbSNP
rs1250850840 2339 dbSNP
rs886058328 2341 dbSNP
rs1214736934 2342 dbSNP
rs1005400798 2349 dbSNP
rs532935529 2354 dbSNP
rs1214285895 2358 dbSNP
rs1334100088 2364 dbSNP
rs546652502 2369 dbSNP
rs1416159102 2371 dbSNP
rs1362853559 2400 dbSNP
rs1269894368 2401 dbSNP
rs1433349073 2403 dbSNP
rs1373703229 2406 dbSNP
rs924751305 2407 dbSNP
rs936107923 2411 dbSNP
rs1392953347 2415 dbSNP
rs1162004406 2419 dbSNP
rs886058329 2426 dbSNP
rs1419771900 2432 dbSNP
rs1185638932 2436 dbSNP
rs886058330 2438 dbSNP
rs1447399525 2441 dbSNP
rs1166372828 2445 dbSNP
rs1254597364 2446 dbSNP
rs1272332599 2446 dbSNP
rs1194062753 2447 dbSNP
rs1467925911 2448 dbSNP
rs1029789160 2449 dbSNP
rs1263626922 2455 dbSNP
rs566359371 2462 dbSNP
rs1206706562 2483 dbSNP
rs79535432 2484 dbSNP
rs774000972 2489 dbSNP
rs932668855 2492 dbSNP
rs1460573343 2494 dbSNP
rs1051499238 2497 dbSNP
rs890381329 2504 dbSNP
rs1350347882 2506 dbSNP
rs1299934849 2510 dbSNP
rs1008741461 2520 dbSNP
rs1397242616 2523 dbSNP
rs1033150612 2525 dbSNP
rs1311222691 2529 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 7048.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgGUCGAUUGUUAUGUGACGGa 5'
            :||||  |  | ||||||| 
Target 5' auUAGCU--CUUUCCACUGCCu 3'
 		6 - 25
Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000359013.4 | 3UTR | UAAACAUUAGCUCUUUCCACUGCCUACC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE38974 Chronic obstructive pulmonary disease -0.447 1.3e-2 -0.459 1.0e-2 25 Click to see details
GSE28544 Breast cancer -0.423 2.0e-2 -0.347 4.8e-2 24 Click to see details
GSE35602 Colorectal cancer stromal tissue -0.36 3.9e-2 -0.188 1.8e-1 25 Click to see details
GSE42095 Differentiated embryonic stem cells -0.344 5.4e-2 -0.073 3.7e-1 23 Click to see details
GSE19783 ER- ER- breast cancer -0.163 7.6e-2 -0.139 1.1e-1 79 Click to see details
GSE19783 ER+ ER+ breast cancer 0.288 1.1e-1 0.278 1.2e-1 20 Click to see details
GSE28260 Renal cortex and medulla 0.315 1.5e-1 0.176 2.8e-1 13 Click to see details
GSE27834 Pluripotent stem cells -0.268 1.6e-1 -0.356 8.8e-2 16 Click to see details
GSE26953 Aortic valvular endothelial cells 0.212 1.6e-1 0.292 8.3e-2 24 Click to see details
GSE21849 B cell lymphoma 0.128 2.5e-1 0.057 3.8e-1 29 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.275 2.5e-1 0.024 4.8e-1 8 Click to see details
GSE21687 Ependynoma primary tumors -0.077 2.7e-1 -0.042 3.7e-1 64 Click to see details
GSE17306 Multiple myeloma -0.082 2.9e-1 0.187 9.9e-2 49 Click to see details
GSE38226 Liver fibrosis -0.118 3.1e-1 -0.111 3.2e-1 21 Click to see details
GSE19350 CNS germ cell tumors -0.116 3.6e-1 0.252 2.1e-1 12 Click to see details
GSE14794 Lymphoblastoid cells -0.038 3.6e-1 -0.115 1.4e-1 90 Click to see details
GSE32688 Pancreatic cancer -0.055 3.8e-1 0.073 3.5e-1 32 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.06 4.0e-1 -0.370 5.4e-2 20 Click to see details
GSE17498 Multiple myeloma 0.025 4.4e-1 -0.263 5.1e-2 40 Click to see details
GSE19536 Breast cancer 0.004 4.8e-1 -0.009 4.6e-1 100 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
UCEC -0.445 0.13 -0.381 0.18 8 Click to see details
THCA -0.835 0.19 -1.000 0.5 3 Click to see details
BRCA -0.414 0.29 -0.800 0.1 4 Click to see details
LUSC 0.205 0.4 0.000 0.5 4 Click to see details
LUSC 0.205 0.4 0.000 0.5 4 Click to see details
LUSC 0.205 0.4 0.000 0.5 4 Click to see details
LUSC 0.205 0.4 0.000 0.5 4 Click to see details
LUSC 0.205 0.4 0.000 0.5 4 Click to see details
109 hsa-miR-449b-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006349 SIRT1 sirtuin 1 2 1
MIRT006350 CCNE2 cyclin E2 4 3
MIRT006351 MET MET proto-oncogene, receptor tyrosine kinase 2 1
MIRT006352 GMNN geminin, DNA replication inhibitor 2 1
MIRT006353 HDAC1 histone deacetylase 1 2 1
MIRT016137 CDK4 cyclin dependent kinase 4 1 1
MIRT016138 CDC25A cell division cycle 25A 2 1
MIRT016139 CDK6 cyclin dependent kinase 6 4 3
MIRT057740 ZDHHC16 zinc finger DHHC-type containing 16 2 2
MIRT078636 FAM104A family with sequence similarity 104 member A 2 2
MIRT100407 HSPA1B heat shock protein family A (Hsp70) member 1B 2 2
MIRT115552 MAZ MYC associated zinc finger protein 2 2
MIRT130146 TXNIP thioredoxin interacting protein 2 4
MIRT142254 DCTN5 dynactin subunit 5 2 2
MIRT143724 CCL22 C-C motif chemokine ligand 22 2 2
MIRT168101 E2F3 E2F transcription factor 3 2 2
MIRT169809 GIGYF1 GRB10 interacting GYF protein 1 2 4
MIRT183694 MDM4 MDM4, p53 regulator 2 2
MIRT198922 SMAD4 SMAD family member 4 2 2
MIRT202950 TSN translin 2 4
MIRT221565 CBX3 chromobox 3 2 2
MIRT253418 EVI5L ecotropic viral integration site 5 like 2 2
MIRT294759 ZNF551 zinc finger protein 551 2 4
MIRT307053 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT331273 TM9SF3 transmembrane 9 superfamily member 3 2 6
MIRT372293 UBXN2B UBX domain protein 2B 2 2
MIRT374317 MBD6 methyl-CpG binding domain protein 6 2 2
MIRT445817 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT447158 MFSD8 major facilitator superfamily domain containing 8 2 2
MIRT447823 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT448798 GMFB glia maturation factor beta 2 2
MIRT451580 HIRIP3 HIRA interacting protein 3 2 2
MIRT452679 GPR156 G protein-coupled receptor 156 2 2
MIRT453158 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT453634 SLC4A2 solute carrier family 4 member 2 2 2
MIRT455384 PLA2G2D phospholipase A2 group IID 2 2
MIRT456958 SPAM1 sperm adhesion molecule 1 2 2
MIRT462739 EFNB1 ephrin B1 2 2
MIRT464321 UST uronyl 2-sulfotransferase 2 2
MIRT465641 TNRC18P2 trinucleotide repeat containing 18 pseudogene 2 2 10
MIRT466748 SYNGR2 synaptogyrin 2 2 2
MIRT468345 SF3B3 splicing factor 3b subunit 3 2 2
MIRT469324 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT474361 KMT2D lysine methyltransferase 2D 2 2
MIRT475316 IFNLR1 interferon lambda receptor 1 2 2
MIRT477759 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT477824 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT478265 DDX19B DEAD-box helicase 19B 2 2
MIRT481042 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 2
MIRT481289 ATXN1L ataxin 1 like 2 2
MIRT482730 COPZ1 coatomer protein complex subunit zeta 1 2 2
MIRT488780 CYTH3 cytohesin 3 2 2
MIRT489578 SSBP2 single stranded DNA binding protein 2 2 2
MIRT489659 SHMT1 serine hydroxymethyltransferase 1 2 4
MIRT490527 KIAA1715 lunapark, ER junction formation factor 2 2
MIRT492949 NEUROD2 neuronal differentiation 2 2 2
MIRT493154 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT493845 FOXN3 forkhead box N3 2 4
MIRT494743 ARHGAP1 Rho GTPase activating protein 1 2 6
MIRT496491 MAST3 microtubule associated serine/threonine kinase 3 2 2
MIRT503312 FICD FIC domain containing 2 4
MIRT503507 ZNF623 zinc finger protein 623 2 2
MIRT504182 FAM127B retrotransposon Gag like 8A 2 2
MIRT505010 ZNF644 zinc finger protein 644 2 2
MIRT505352 TMEM167A transmembrane protein 167A 2 2
MIRT505645 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT505710 SESN2 sestrin 2 2 2
MIRT505777 SATB2 SATB homeobox 2 2 6
MIRT506208 PHF19 PHD finger protein 19 2 2
MIRT506251 PEG10 paternally expressed 10 2 2
MIRT507786 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT508005 BCL2L13 BCL2 like 13 2 4
MIRT508857 ZRSR1 zinc finger CCCH-type, RNA binding motif and serine/arginine rich 1 2 4
MIRT510546 XBP1P1 X-box binding protein 1 pseudogene 1 2 4
MIRT511892 GAS1 growth arrest specific 1 2 6
MIRT512907 UBL4A ubiquitin like 4A 2 2
MIRT513600 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT521241 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT521321 RRAGD Ras related GTP binding D 2 4
MIRT525281 C18orf32 chromosome 18 open reading frame 32 2 2
MIRT528650 RWDD2A RWD domain containing 2A 2 4
MIRT535101 PODXL podocalyxin like 2 2
MIRT547752 KBTBD6 kelch repeat and BTB domain containing 6 2 4
MIRT547865 HSPA13 heat shock protein family A (Hsp70) member 13 2 2
MIRT549170 BMP3 bone morphogenetic protein 3 2 2
MIRT550115 SLC35G2 solute carrier family 35 member G2 2 2
MIRT556097 MOAP1 modulator of apoptosis 1 2 2
MIRT557172 HOXA13 homeobox A13 2 2
MIRT557422 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT557931 FAM73A mitoguardin 1 2 2
MIRT568804 VPS37D VPS37D, ESCRT-I subunit 2 2
MIRT571326 TPCN2 two pore segment channel 2 2 2
MIRT572598 PAPLN papilin, proteoglycan like sulfated glycoprotein 2 2
MIRT573437 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT574092 VASN vasorin 2 2
MIRT608688 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT608800 ITGA11 integrin subunit alpha 11 2 4
MIRT610332 SSX5 SSX family member 5 2 2
MIRT613158 DDA1 DET1 and DDB1 associated 1 2 2
MIRT625407 CPEB3 cytoplasmic polyadenylation element binding protein 3 2 2
MIRT636603 CLIC5 chloride intracellular channel 5 2 2
MIRT638573 IER5 immediate early response 5 2 2
MIRT639686 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT677979 ITGB3 integrin subunit beta 3 2 2
MIRT685217 POTED POTE ankyrin domain family member D 2 2
MIRT702570 JARID2 jumonji and AT-rich interaction domain containing 2 2 2
MIRT706259 MKLN1 muskelin 1 2 2
MIRT734675 HMGB1 high mobility group box 1 3 0
MIRT736369 HSPA1A heat shock protein family A (Hsp70) member 1A 1 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-449b Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-449b Doxorubicin approved 31703 Quantitative real-time PCR ovarian carcinoma cell line A2780 cells 22340095 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-449b Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-449b Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-449b-5p Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (SUIT-2, CAPAN-1)
hsa-miR-449b-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-449b-5p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Panobinostat 6918837 NSC761190 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer tissue
hsa-miR-449b-5p Fluorouracil 3385 NSC19893 approved resistant High Gastric Cancer tissue
hsa-miR-449b-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-449b-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-449b-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (HeyA8)
hsa-miR-449b-5p Paclitaxel 36314 NSC125973 approved resistant cell line (SKVO3ip1)
hsa-miR-449b-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-449b-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-449b-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-449b-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)
hsa-miR-449b-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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