miRTarBase - #MIRT319752


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pre-miRNA Information
pre-miRNA hsa-mir-548ac   
Genomic Coordinates chr1: 116560024 - 116560111
Description Homo sapiens miR-548ac stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-548ac
Sequence 53| CAAAAACCGGCAAUUACUUUUG |74
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 1 - 116560056 29233923 MiREDiBase
A-to-I 5 1 - 116560055 29233923 MiREDiBase
A-to-I 6 1 - 116560054 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1182074110 6 dbSNP
rs1392446444 6 dbSNP
rs1326234665 7 dbSNP
rs556579863 8 dbSNP
rs993390910 9 dbSNP
rs901450363 13 dbSNP
rs538553306 22 dbSNP
Putative Targets

Gene Information
Gene Symbol LUC7L2   
Synonyms CGI-59, CGI-74, LUC7B2
Description LUC7 like 2, pre-mRNA splicing factor
Transcript NM_016019   
Expression
Putative miRNA Targets on LUC7L2
3'UTR of LUC7L2
(miRNA target sites are highlighted)		 
>LUC7L2|NM_016019|3'UTR
   1 CTAGCTGTGTACATTTCTTCAGTCCTTAAGCTTCCTACGGAGTTACGTACTATTGTTTAGTTCACAGCTGTTCAGGGTGA
  81 CAGTGAGCAGATCCAGACACCAGATCCAGCTAGGCTAGATGTACAGTATCTAACTTGATCTGAACTGAACCTGTTTTCCT
 161 TGATGATGCCTAAAACTACATCCATAGTTTCTGGTGAACCTGTAATACAGTTCTGAAAGTACAGTTTTATATAATAAGAT
 241 GCTGATCTCTTTATTCTTTCAAGTAAGAGTGCTAGTGAACAAATTGTGTTACTTGCCTTGGGATTTTTTGAACGTTTGTA
 321 AAATGCTGTCTTCCTAGTCCAAACAGCTGCAGCTTTGGGCATTTTTCTTTTTAATTATTCTTCCTCTGACTTTGTATCCC
 401 TTAATACCTACACTCTCCAATTGTAAGAGAAAGGGGGCAGGGAAGCAATATAGCTTCCATTCTAAGGCTGTATTCCCGTT
 481 ATGAATTACTAGCTGATTACAGTTCAGAGCATTGATCCTGGAATGTGTGCTGGAGAAATTTAAAATACTGGGGTTTTTTG
 561 TTTAATGGTGCCTATTTAGAGTTGGAAGTTGAACAGCTGTTGCATTACATACTTTTGCTTTTTTATTGAAATTTTGAAAT
 641 CAAACGTCTTGATTTTTCTGTTCTGTTGAATTGCTATGTTCAGGATGTTCTAGGGGGTGGGGGCAGGGACTCTTTTCGTA
 721 ATAAGCACTTGTTTTATTTTGTGTGTGTGGAGTATAAAGGCTACACCCTTATTGTAAAAAAATAATAATAATAAAATGAA
 801 AGAAACAATCACCACCACCATTATTAAACTGTAACTTGTCTAGTAAATTGTCACTAGAACTATTTGCTGTGGGCATTTCC
 881 TCTATTCTGTTACGTCATTAACAGTGCCTTACTGTGCAAGGCACCAAAGGACATAAATACGTACTTGCAAAGATTCCAGA
 961 TGAGCTGTTCATGTGGGCCCCTTGCTGACTATATTCCAGCCACTTCAGGGTTGTTTGTAATGACCGTTATAGAGAAGGGC
1041 TCGACCTGCAGAAGAAACTGGGGTGTTTTTATTCTCATTCAACAAACCCAAATAAAAACAGTATATGTAACCAACAT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' guUUUCAUUAACGGCCAAAAAc 5'
            ||| || | |  ||||||| 
Target 5' ttAAAATACTGG--GGTTTTTt 3'
 540 - 559 156.00 -5.10
2 
miRNA  3' guUUUCAUUAACGGC-CAAAAAc 5'
            :||| || ||  | |||||| 
Target 5' caGAAGAAACTGGGGTGTTTTTa 3'
 1049 - 1071 132.00 -5.82
3 
miRNA  3' guuuucAUUAACGG---CCAAAAAc 5'
                || |||||   || |||| 
Target 5' ttgtgtTACTTGCCTTGGGATTTTt 3'
 284 - 308 128.00 -6.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30180810 5 COSMIC
COSN26968795 12 COSMIC
COSN31593616 13 COSMIC
COSN31547077 18 COSMIC
COSN30523780 21 COSMIC
COSN30509070 36 COSMIC
COSN30116375 47 COSMIC
COSN30508017 48 COSMIC
COSN30494885 60 COSMIC
COSN30541628 68 COSMIC
COSN28858273 69 COSMIC
COSN30538698 100 COSMIC
COSN31609205 222 COSMIC
COSN22810692 229 COSMIC
COSN31607394 311 COSMIC
COSN26563972 358 COSMIC
COSN28196134 369 COSMIC
COSN29264616 521 COSMIC
COSN28651608 575 COSMIC
COSN28650400 654 COSMIC
COSN26465219 685 COSMIC
COSN32056050 718 COSMIC
COSN26638121 719 COSMIC
COSN31543032 803 COSMIC
COSN31549520 1006 COSMIC
COSN31572650 1024 COSMIC
COSN31527503 1058 COSMIC
COSN19273039 1083 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs772226970 4 dbSNP
rs759390623 8 dbSNP
rs764982534 9 dbSNP
rs370523505 10 dbSNP
rs1250851453 11 dbSNP
rs758350536 13 dbSNP
rs1229552240 14 dbSNP
rs777531974 21 dbSNP
rs1308114513 22 dbSNP
rs1277648018 25 dbSNP
rs751083656 32 dbSNP
rs756661866 38 dbSNP
rs372923022 39 dbSNP
rs745511457 40 dbSNP
rs1463166421 43 dbSNP
rs377113094 47 dbSNP
rs370218831 48 dbSNP
rs1038612969 50 dbSNP
rs749624906 51 dbSNP
rs1291853216 53 dbSNP
rs769239771 53 dbSNP
rs1226461803 59 dbSNP
rs1169326382 61 dbSNP
rs938581541 65 dbSNP
rs1055655315 68 dbSNP
rs915548327 71 dbSNP
rs930979628 72 dbSNP
rs1476593464 74 dbSNP
rs894456182 77 dbSNP
rs1187881589 78 dbSNP
rs1267475584 78 dbSNP
rs1356374330 82 dbSNP
rs1458166537 85 dbSNP
rs552497761 85 dbSNP
rs1211142955 91 dbSNP
rs1257404111 94 dbSNP
rs1216866170 102 dbSNP
rs750457487 104 dbSNP
rs758698478 107 dbSNP
rs6951868 108 dbSNP
rs763537513 116 dbSNP
rs1182522704 127 dbSNP
rs1339031566 134 dbSNP
rs751676692 135 dbSNP
rs1031913090 138 dbSNP
rs1400208848 140 dbSNP
rs892997238 158 dbSNP
rs1463590471 161 dbSNP
rs1182061387 173 dbSNP
rs1163440774 186 dbSNP
rs753941674 187 dbSNP
rs901362661 190 dbSNP
rs997074765 191 dbSNP
rs1369573823 207 dbSNP
rs1017553408 221 dbSNP
rs1029002048 223 dbSNP
rs538309628 230 dbSNP
rs1196725760 231 dbSNP
rs1469840572 232 dbSNP
rs1290716635 236 dbSNP
rs1209407834 237 dbSNP
rs550319684 240 dbSNP
rs958026843 243 dbSNP
rs1011322730 244 dbSNP
rs1240169022 245 dbSNP
rs1390219956 248 dbSNP
rs1376696683 250 dbSNP
rs1430634384 250 dbSNP
rs1443798382 252 dbSNP
rs1372460014 253 dbSNP
rs1310127252 259 dbSNP
rs1030046595 261 dbSNP
rs1020989475 270 dbSNP
rs7785408 275 dbSNP
rs1159976472 277 dbSNP
rs1407788755 298 dbSNP
rs1420059487 301 dbSNP
rs983255437 303 dbSNP
rs1176657913 304 dbSNP
rs1455535450 305 dbSNP
rs1247279764 313 dbSNP
rs752571683 314 dbSNP
rs375790992 315 dbSNP
rs1286583100 337 dbSNP
rs1217655887 338 dbSNP
rs755857338 340 dbSNP
rs1284334050 341 dbSNP
rs568596143 345 dbSNP
rs974266929 348 dbSNP
rs1263152435 375 dbSNP
rs1274843684 389 dbSNP
rs1435084183 391 dbSNP
rs189437456 392 dbSNP
rs1319828123 395 dbSNP
rs1205390128 411 dbSNP
rs1276395693 413 dbSNP
rs1482251570 421 dbSNP
rs1156599876 423 dbSNP
rs1204934030 449 dbSNP
rs749160785 450 dbSNP
rs1045703116 452 dbSNP
rs907233171 453 dbSNP
rs1243952295 455 dbSNP
rs1257398598 460 dbSNP
rs1426091718 463 dbSNP
rs1488095843 469 dbSNP
rs934726876 472 dbSNP
rs1127422 478 dbSNP
rs180785796 479 dbSNP
rs1048525022 484 dbSNP
rs1450218414 503 dbSNP
rs1278505550 510 dbSNP
rs892938327 511 dbSNP
rs1368978464 512 dbSNP
rs1342209802 519 dbSNP
rs1011423940 525 dbSNP
rs908227678 528 dbSNP
rs1339442172 530 dbSNP
rs939729574 538 dbSNP
rs1402718540 542 dbSNP
rs567158217 549 dbSNP
rs1359549726 553 dbSNP
rs1040830706 554 dbSNP
rs1397708769 554 dbSNP
rs997474487 564 dbSNP
rs901308850 567 dbSNP
rs997021085 569 dbSNP
rs1477573342 570 dbSNP
rs1049965457 571 dbSNP
rs894041501 574 dbSNP
rs1127424 575 dbSNP
rs1483753122 579 dbSNP
rs1237296843 591 dbSNP
rs1208558013 601 dbSNP
rs185143772 604 dbSNP
rs576777189 605 dbSNP
rs1259347111 609 dbSNP
rs1021355368 614 dbSNP
rs966699626 616 dbSNP
rs1228531437 617 dbSNP
rs753206338 618 dbSNP
rs1003554205 621 dbSNP
rs1275860299 625 dbSNP
rs1005015025 626 dbSNP
rs1379547056 638 dbSNP
rs577783795 646 dbSNP
rs963169908 647 dbSNP
rs9683 654 dbSNP
rs1465145376 656 dbSNP
rs991727176 659 dbSNP
rs1167320083 666 dbSNP
rs1022829931 667 dbSNP
rs1413449899 668 dbSNP
rs1484483581 671 dbSNP
rs191308607 672 dbSNP
rs1199219740 674 dbSNP
rs1180465546 676 dbSNP
rs1243090550 679 dbSNP
rs1471384916 686 dbSNP
rs1465369344 692 dbSNP
rs1178593621 698 dbSNP
rs757317770 713 dbSNP
rs1255616878 715 dbSNP
rs952721710 718 dbSNP
rs1321937424 719 dbSNP
rs771787156 731 dbSNP
rs538777581 732 dbSNP
rs1226365768 737 dbSNP
rs764888731 740 dbSNP
rs1177142567 746 dbSNP
rs934698535 751 dbSNP
rs541623322 761 dbSNP
rs914671482 767 dbSNP
rs1467437013 772 dbSNP
rs1458526042 773 dbSNP
rs947167040 775 dbSNP
rs1038883501 776 dbSNP
rs1421854413 776 dbSNP
rs1381353493 781 dbSNP
rs1438404120 781 dbSNP
rs747878107 781 dbSNP
rs144910314 783 dbSNP
rs1051710184 784 dbSNP
rs908181554 785 dbSNP
rs1218951846 791 dbSNP
rs1355531807 792 dbSNP
rs1286474680 793 dbSNP
rs1239264634 794 dbSNP
rs746573066 798 dbSNP
rs939677246 798 dbSNP
rs1435108890 801 dbSNP
rs976460022 803 dbSNP
rs202111615 807 dbSNP
rs922344924 809 dbSNP
rs1016387909 810 dbSNP
rs1127435 812 dbSNP
rs1127437 815 dbSNP
rs1402088264 816 dbSNP
rs3183420 818 dbSNP
rs1361510200 830 dbSNP
rs183009949 834 dbSNP
rs1418331586 842 dbSNP
rs1301598687 849 dbSNP
rs1011982634 851 dbSNP
rs1177482281 855 dbSNP
rs1231565319 863 dbSNP
rs1433210727 865 dbSNP
rs1262989404 877 dbSNP
rs1423889672 880 dbSNP
rs1050336631 885 dbSNP
rs1489074498 886 dbSNP
rs1263527024 890 dbSNP
rs1215620552 892 dbSNP
rs186812222 894 dbSNP
rs893996851 895 dbSNP
rs552205848 908 dbSNP
rs1233923425 909 dbSNP
rs970221791 920 dbSNP
rs747413976 929 dbSNP
rs1220611523 934 dbSNP
rs1246260426 941 dbSNP
rs546504736 942 dbSNP
rs1485606872 944 dbSNP
rs1404822313 945 dbSNP
rs564479474 966 dbSNP
rs1465980815 974 dbSNP
rs1358013497 975 dbSNP
rs1173613708 978 dbSNP
rs1478554987 979 dbSNP
rs981634094 982 dbSNP
rs1491583209 988 dbSNP
rs1491113817 989 dbSNP
rs1200908753 992 dbSNP
rs1482880631 993 dbSNP
rs531715317 994 dbSNP
rs1200575764 995 dbSNP
rs191541492 996 dbSNP
rs1434648400 1001 dbSNP
rs1217063796 1011 dbSNP
rs1342565945 1014 dbSNP
rs568558330 1015 dbSNP
rs536000978 1026 dbSNP
rs547921171 1030 dbSNP
rs914596485 1031 dbSNP
rs1333999830 1032 dbSNP
rs566149385 1033 dbSNP
rs947444986 1035 dbSNP
rs1039166770 1043 dbSNP
rs895224502 1044 dbSNP
rs1460164840 1048 dbSNP
rs1012359118 1062 dbSNP
rs933152765 1064 dbSNP
rs571411156 1067 dbSNP
rs540090427 1070 dbSNP
rs1180452433 1079 dbSNP
rs558187559 1083 dbSNP
rs1005248242 1086 dbSNP
rs952590195 1087 dbSNP
rs570050980 1088 dbSNP
rs1037360660 1089 dbSNP
rs1385392920 1094 dbSNP
rs1283025776 1095 dbSNP
rs1266326907 1099 dbSNP
rs898862161 1104 dbSNP
rs537440248 1109 dbSNP
rs555789346 1115 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000541515.3 | 3UTR | AUAGGUUUUUUUUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
275 hsa-miR-548ac Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055863 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT074959 LEPROT leptin receptor overlapping transcript 2 2
MIRT076823 SUZ12 SUZ12 polycomb repressive complex 2 subunit 2 4
MIRT078708 LLGL2 LLGL2, scribble cell polarity complex component 2 2
MIRT099610 ID4 inhibitor of DNA binding 4, HLH protein 2 4
MIRT103362 CBX3 chromobox 3 2 2
MIRT111801 MPZL1 myelin protein zero like 1 2 2
MIRT114050 AKAP11 A-kinase anchoring protein 11 2 12
MIRT133719 SKI SKI proto-oncogene 2 2
MIRT136817 NHLRC3 NHL repeat containing 3 2 6
MIRT149926 LDLR low density lipoprotein receptor 2 2
MIRT166915 TNPO1 transportin 1 2 2
MIRT168142 SOX4 SRY-box 4 2 10
MIRT190787 STRN3 striatin 3 2 4
MIRT207471 RMND5A required for meiotic nuclear division 5 homolog A 2 2
MIRT250951 CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 2 4
MIRT271993 ARF1 ADP ribosylation factor 1 2 4
MIRT282618 IGF1R insulin like growth factor 1 receptor 2 8
MIRT294153 ZNF845 zinc finger protein 845 2 2
MIRT309060 C4ORF3 chromosome 4 open reading frame 3 2 2
MIRT318548 SYNCRIP synaptotagmin binding cytoplasmic RNA interacting protein 2 2
MIRT319752 LUC7L2 LUC7 like 2, pre-mRNA splicing factor 2 2
MIRT331324 TM9SF3 transmembrane 9 superfamily member 3 2 2
MIRT337204 TOMM20 translocase of outer mitochondrial membrane 20 2 6
MIRT346145 ALYREF Aly/REF export factor 2 2
MIRT347727 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT350503 MRGBP MRG domain binding protein 2 6
MIRT356409 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT357986 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT374399 M6PR mannose-6-phosphate receptor, cation dependent 2 6
MIRT442727 TMEM158 transmembrane protein 158 (gene/pseudogene) 2 2
MIRT443411 HMX3 H6 family homeobox 3 2 2
MIRT444408 FRMD5 FERM domain containing 5 2 2
MIRT444469 PTPRG protein tyrosine phosphatase, receptor type G 2 2
MIRT444650 HSBP1 heat shock factor binding protein 1 2 2
MIRT444861 EXD2 exonuclease 3'-5' domain containing 2 2 2
MIRT445685 TNFSF15 TNF superfamily member 15 2 2
MIRT446001 CD1D CD1d molecule 2 2
MIRT446074 RABIF RAB interacting factor 2 2
MIRT446308 ACSL3 acyl-CoA synthetase long chain family member 3 2 2
MIRT446432 ABHD2 abhydrolase domain containing 2 2 2
MIRT447269 C3orf30 chromosome 3 open reading frame 30 2 2
MIRT447759 TMCC3 transmembrane and coiled-coil domain family 3 2 2
MIRT448161 P2RY10 purinergic receptor P2Y10 2 2
MIRT449049 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 2 2
MIRT449275 PALM2 paralemmin 2 2 2
MIRT450122 IMP3 IMP3, U3 small nucleolar ribonucleoprotein 2 2
MIRT450155 GABRB3 gamma-aminobutyric acid type A receptor beta3 subunit 2 2
MIRT451289 ZNF101 zinc finger protein 101 2 2
MIRT459253 ADRBK1 G protein-coupled receptor kinase 2 2 2
MIRT462554 NUDT19 nudix hydrolase 19 2 2
MIRT464470 UGCG UDP-glucose ceramide glucosyltransferase 2 2
MIRT465120 TSC22D2 TSC22 domain family member 2 2 4
MIRT467996 SKIL SKI like proto-oncogene 2 2
MIRT468718 SDC4 syndecan 4 2 2
MIRT469269 RHOB ras homolog family member B 2 2
MIRT470675 POLR2D RNA polymerase II subunit D 2 4
MIRT470723 POGK pogo transposable element derived with KRAB domain 2 2
MIRT471438 PDIA6 protein disulfide isomerase family A member 6 2 2
MIRT471502 PDE4D phosphodiesterase 4D 2 4
MIRT471988 NR2F2 nuclear receptor subfamily 2 group F member 2 2 4
MIRT472386 NEK7 NIMA related kinase 7 2 2
MIRT475028 KANSL1 KAT8 regulatory NSL complex subunit 1 2 8
MIRT479411 CDKN1B cyclin dependent kinase inhibitor 1B 2 10
MIRT480514 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT481700 AR androgen receptor 2 2
MIRT482543 ACTB actin beta 2 4
MIRT482627 ABCE1 ATP binding cassette subfamily E member 1 2 2
MIRT484725 INHBA inhibin beta A subunit 2 12
MIRT487778 ANKEF1 ankyrin repeat and EF-hand domain containing 1 2 16
MIRT491883 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT494653 ARNTL aryl hydrocarbon receptor nuclear translocator like 2 2
MIRT497366 SF1 splicing factor 1 2 2
MIRT499156 HSPA1B heat shock protein family A (Hsp70) member 1B 2 8
MIRT502830 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 6
MIRT502944 CDC37L1 cell division cycle 37 like 1 2 8
MIRT503942 FBXL13 F-box and leucine rich repeat protein 13 2 4
MIRT504235 MYO6 myosin VI 2 2
MIRT504453 MC2R melanocortin 2 receptor 2 2
MIRT506022 PURA purine rich element binding protein A 2 2
MIRT508028 BCAT1 branched chain amino acid transaminase 1 2 4
MIRT508299 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 4
MIRT511515 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT512307 AMER1 APC membrane recruitment protein 1 2 6
MIRT514565 XRCC3 X-ray repair cross complementing 3 2 4
MIRT515657 MYBPC1 myosin binding protein C, slow type 2 2
MIRT518429 SSU72 SSU72 homolog, RNA polymerase II CTD phosphatase 2 2
MIRT520378 UBE2D1 ubiquitin conjugating enzyme E2 D1 2 4
MIRT521604 PSMA2 proteasome subunit alpha 2 2 4
MIRT521725 PPP3R1 protein phosphatase 3 regulatory subunit B, alpha 2 4
MIRT522579 MBNL3 muscleblind like splicing regulator 3 2 4
MIRT522731 LRRC55 leucine rich repeat containing 55 2 8
MIRT524547 CDC5L cell division cycle 5 like 2 4
MIRT525371 SYNM synemin 2 2
MIRT526489 PPIA peptidylprolyl isomerase A 2 4
MIRT527197 CLASP1 cytoplasmic linker associated protein 1 2 2
MIRT527285 FBLN2 fibulin 2 2 2
MIRT527383 MGARP mitochondria localized glutamic acid rich protein 2 2
MIRT527409 SMU1 DNA replication regulator and spliceosomal factor 2 6
MIRT527454 COL4A3 collagen type IV alpha 3 chain 2 2
MIRT528348 TBC1D22B TBC1 domain family member 22B 2 2
MIRT529104 ZNF100 zinc finger protein 100 2 2
MIRT529317 ATRNL1 attractin like 1 2 2
MIRT529328 PDE5A phosphodiesterase 5A 2 2
MIRT529750 SEL1L SEL1L ERAD E3 ligase adaptor subunit 2 2
MIRT530277 MKRN3 makorin ring finger protein 3 2 2
MIRT531415 TMEM18 transmembrane protein 18 2 2
MIRT532544 WDR13 WD repeat domain 13 2 2
MIRT533245 VKORC1L1 vitamin K epoxide reductase complex subunit 1 like 1 2 2
MIRT534659 RNF20 ring finger protein 20 2 2
MIRT534818 RAB33B RAB33B, member RAS oncogene family 2 2
MIRT537492 FAM169A family with sequence similarity 169 member A 2 2
MIRT538778 CABLES1 Cdk5 and Abl enzyme substrate 1 2 2
MIRT539122 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT540964 SLC25A43 solute carrier family 25 member 43 2 2
MIRT541403 CDC27 cell division cycle 27 2 2
MIRT543353 ZNF829 zinc finger protein 829 2 2
MIRT543623 MFAP3 microfibril associated protein 3 2 2
MIRT543649 YY2 YY2 transcription factor 2 2
MIRT544945 SNCB synuclein beta 2 2
MIRT545327 SPC25 SPC25, NDC80 kinetochore complex component 2 2
MIRT546094 VEZF1 vascular endothelial zinc finger 1 2 2
MIRT548605 DCUN1D3 defective in cullin neddylation 1 domain containing 3 2 2
MIRT548638 DAZAP1 DAZ associated protein 1 2 4
MIRT550318 ZNF681 zinc finger protein 681 2 2
MIRT550412 SLC29A1 solute carrier family 29 member 1 (Augustine blood group) 2 4
MIRT551034 SPPL3 signal peptide peptidase like 3 2 2
MIRT551602 HDGFRP2 HDGF like 2 2 2
MIRT552064 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 4
MIRT552803 YAF2 YY1 associated factor 2 2 2
MIRT553274 TVP23C trans-golgi network vesicle protein 23 homolog C 2 2
MIRT553303 TSPAN3 tetraspanin 3 2 2
MIRT553570 NPM3 nucleophosmin/nucleoplasmin 3 2 2
MIRT554844 RECK reversion inducing cysteine rich protein with kazal motifs 2 2
MIRT556069 MTF2 metal response element binding transcription factor 2 2 4
MIRT556898 ITGA2 integrin subunit alpha 2 2 2
MIRT558680 CNIH cornichon family AMPA receptor auxiliary protein 1 1 1
MIRT559032 C20orf24 chromosome 20 open reading frame 24 2 2
MIRT559108 C18orf25 chromosome 18 open reading frame 25 2 2
MIRT559864 GSKIP GSK3B interacting protein 2 2
MIRT560868 GAL3ST3 galactose-3-O-sulfotransferase 3 2 2
MIRT562268 GRB2 growth factor receptor bound protein 2 2 2
MIRT562419 EIF2S2 eukaryotic translation initiation factor 2 subunit beta 2 2
MIRT562652 ARID1A AT-rich interaction domain 1A 2 4
MIRT563771 ZNF678 zinc finger protein 678 2 2
MIRT564279 DEPDC1B DEP domain containing 1B 2 2
MIRT565253 TRA2B transformer 2 beta homolog 2 4
MIRT565307 TMEM64 transmembrane protein 64 2 2
MIRT566034 RFX1 regulatory factor X1 2 2
MIRT566714 MTMR3 myotubularin related protein 3 2 2
MIRT568087 CELF2 CUGBP Elav-like family member 2 2 2
MIRT568417 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT568766 MYBL1 MYB proto-oncogene like 1 2 2
MIRT569516 THYN1 thymocyte nuclear protein 1 2 2
MIRT571823 PHF19 PHD finger protein 19 2 2
MIRT571995 HOXA9 homeobox A9 2 2
MIRT572174 CELF1 CUGBP Elav-like family member 1 2 2
MIRT572637 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT573756 KHSRP KH-type splicing regulatory protein 2 2
MIRT574089 CCDC132 VPS50, EARP/GARPII complex subunit 2 6
MIRT574311 CMTM6 CKLF like MARVEL transmembrane domain containing 6 2 2
MIRT574512 PSAT1 phosphoserine aminotransferase 1 2 2
MIRT574559 NRBF2 nuclear receptor binding factor 2 2 2
MIRT576686 H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 2 2
MIRT608491 NKTR natural killer cell triggering receptor 2 6
MIRT608640 ATP9A ATPase phospholipid transporting 9A (putative) 2 6
MIRT609231 TMEM189 transmembrane protein 189 2 2
MIRT609561 TCEAL4 transcription elongation factor A like 4 2 2
MIRT610193 FAM49A family with sequence similarity 49 member A 2 2
MIRT610681 SYT2 synaptotagmin 2 2 4
MIRT610725 NAV2 neuron navigator 2 2 2
MIRT610813 SGOL2 shugoshin 2 2 2
MIRT610993 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT611030 KCNK10 potassium two pore domain channel subfamily K member 10 2 2
MIRT611339 SLC2A4 solute carrier family 2 member 4 2 2
MIRT611511 HIPK3 homeodomain interacting protein kinase 3 2 2
MIRT611638 EDIL3 EGF like repeats and discoidin domains 3 2 2
MIRT611856 RPL3L ribosomal protein L3 like 2 2
MIRT611905 TRPC3 transient receptor potential cation channel subfamily C member 3 2 2
MIRT612047 PCNXL2 pecanex homolog 2 2 6
MIRT612340 TRIB2 tribbles pseudokinase 2 2 2
MIRT612870 INO80C INO80 complex subunit C 2 2
MIRT613555 AMPD3 adenosine monophosphate deaminase 3 2 2
MIRT614490 MMS22L MMS22 like, DNA repair protein 2 2
MIRT615098 BRD4 bromodomain containing 4 2 2
MIRT616228 PTPN11 protein tyrosine phosphatase, non-receptor type 11 2 2
MIRT617220 GDPGP1 GDP-D-glucose phosphorylase 1 2 2
MIRT617884 ESR1 estrogen receptor 1 2 2
MIRT618344 CD59 CD59 molecule (CD59 blood group) 2 2
MIRT620264 RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 2 2
MIRT620660 CCDC108 cilia and flagella associated protein 65 2 2
MIRT620761 CCR5 C-C motif chemokine receptor 5 (gene/pseudogene) 2 2
MIRT621416 TXNL1 thioredoxin like 1 2 2
MIRT621676 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT622231 SLC25A51 solute carrier family 25 member 51 2 2
MIRT622377 SALL1 spalt like transcription factor 1 2 2
MIRT622404 RRAGC Ras related GTP binding C 2 2
MIRT622494 RC3H1 ring finger and CCCH-type domains 1 2 2
MIRT623064 NRXN1 neurexin 1 2 2
MIRT623295 MAX MYC associated factor X 2 2
MIRT623691 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT623930 FMNL3 formin like 3 2 2
MIRT623984 FAM208A family with sequence similarity 208 member A 2 2
MIRT624513 C7orf55-LUC7L2 C7orf55-LUC7L2 readthrough 2 2
MIRT624668 ARID4A AT-rich interaction domain 4A 2 2
MIRT624756 ANGPTL2 angiopoietin like 2 2 2
MIRT624949 MARCH2 membrane associated ring-CH-type finger 2 2 2
MIRT625968 RNF2 ring finger protein 2 2 2
MIRT626415 KIAA2018 upstream transcription factor family member 3 2 2
MIRT626882 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
MIRT627157 ZNF652 zinc finger protein 652 2 2
MIRT627613 SFT2D2 SFT2 domain containing 2 2 2
MIRT627744 RAP2B RAP2B, member of RAS oncogene family 2 4
MIRT627808 PTEN phosphatase and tensin homolog 2 2
MIRT627820 PRR3 proline rich 3 2 2
MIRT630935 UNC93A unc-93 homolog A 2 2
MIRT635930 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT638301 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT638437 PNRC1 proline rich nuclear receptor coactivator 1 2 2
MIRT640281 TCF24 transcription factor 24 2 2
MIRT641979 PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2 2
MIRT644179 GIN1 gypsy retrotransposon integrase 1 2 2
MIRT644439 VDR vitamin D receptor 2 2
MIRT644974 STEAP4 STEAP4 metalloreductase 2 2
MIRT647653 B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) 2 2
MIRT648702 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT650120 ZCCHC9 zinc finger CCHC-type containing 9 2 2
MIRT650505 UFM1 ubiquitin fold modifier 1 2 2
MIRT650701 CLNK cytokine dependent hematopoietic cell linker 2 2
MIRT651083 ZNF518B zinc finger protein 518B 2 4
MIRT653644 SLC30A1 solute carrier family 30 member 1 2 2
MIRT653788 SIX4 SIX homeobox 4 2 2
MIRT656773 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT656949 KIAA1456 KIAA1456 2 2
MIRT656981 KDM5A lysine demethylase 5A 2 2
MIRT657225 TOR1AIP2 torsin 1A interacting protein 2 2 4
MIRT657706 GPC5 glypican 5 2 2
MIRT660107 BTBD3 BTB domain containing 3 2 2
MIRT662817 C9orf64 chromosome 9 open reading frame 64 2 2
MIRT665889 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT668140 GINS2 GINS complex subunit 2 2 2
MIRT668566 ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit 2 2
MIRT669718 AAGAB alpha and gamma adaptin binding protein 2 2
MIRT685693 TRIM45 tripartite motif containing 45 2 2
MIRT686579 TMPPE transmembrane protein with metallophosphoesterase domain 2 2
MIRT687491 NHLRC2 NHL repeat containing 2 2 2
MIRT687805 KCNJ15 potassium voltage-gated channel subfamily J member 15 2 2
MIRT687968 HHIP hedgehog interacting protein 2 2
MIRT689487 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT689595 NUDT7 nudix hydrolase 7 2 2
MIRT690501 RSRC1 arginine and serine rich coiled-coil 1 2 2
MIRT692290 XRN2 5'-3' exoribonuclease 2 2 2
MIRT693060 KIAA1324 KIAA1324 2 2
MIRT697443 ZFHX3 zinc finger homeobox 3 2 2
MIRT698475 TJP1 tight junction protein 1 2 2
MIRT699033 SOAT1 sterol O-acyltransferase 1 2 2
MIRT699785 SEMA4D semaphorin 4D 2 2
MIRT701463 NEO1 neogenin 1 2 2
MIRT701869 MRO maestro 2 2
MIRT702158 MAP3K1 mitogen-activated protein kinase kinase kinase 1 2 2
MIRT703750 FAM126B family with sequence similarity 126 member B 2 2
MIRT704277 DGS2 DiGeorge syndrome/velocardiofacial syndrome complex 2 2 2
MIRT707956 PGM3 phosphoglucomutase 3 2 2
MIRT712747 LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 2 2
MIRT712848 RHOA ras homolog family member A 2 2
MIRT712954 CCBE1 collagen and calcium binding EGF domains 1 2 2
MIRT713119 U2SURP U2 snRNP associated SURP domain containing 2 2
MIRT713148 PKIA cAMP-dependent protein kinase inhibitor alpha 2 2
MIRT715394 TADA3 transcriptional adaptor 3 2 2
MIRT715475 NEGR1 neuronal growth regulator 1 2 2
MIRT715535 G2E3 G2/M-phase specific E3 ubiquitin protein ligase 2 2
MIRT721159 MYOCD myocardin 2 2
MIRT722719 ZNF460 zinc finger protein 460 2 2
MIRT723130 GTF2F2 general transcription factor IIF subunit 2 2 2
MIRT723259 TMLHE trimethyllysine hydroxylase, epsilon 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-54 Nicotine approved 89594 Microarray Caenorhabditis elegans 23765240 2013 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-548ac Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-548ac Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-548ac Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-548ac Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-548ac Paclitaxel 36314 NSC125973 approved sensitive cell line (HS578T)
hsa-miR-548ac Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-548ac Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-548ac Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-548ac Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-548ac Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)

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