miRTarBase - #MIRT320405


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pre-miRNA Information
pre-miRNA hsa-mir-1185-1   
Genomic Coordinates chr14: 101042977 - 101043062
Synonyms MIRN1185-1, hsa-mir-1185-1, MIR1185-1
Description Homo sapiens miR-1185-1 stem-loop
Comment This sequence was proposed as a miRNA candidate by Berezikov et al by RAKE analysis .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-1185-1-3p
Sequence 53| AUAUACAGGGGGAGACUCUUAU |74
Evidence Not_experimental
Experiments
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 5 14 + 101043033 29233923 MiREDiBase
A-to-I 7 14 + 101043035 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs749794228 1 dbSNP
rs369414498 4 dbSNP
rs771096180 5 dbSNP
rs774958411 7 dbSNP
rs1226171972 11 dbSNP
rs1449899083 14 dbSNP
rs761183893 16 dbSNP
rs1380874583 20 dbSNP
rs771625921 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol HOXA9   
Synonyms ABD-B, HOX1, HOX1.7, HOX1G
Description homeobox A9
Transcript NM_152739   
Expression
Putative miRNA Targets on HOXA9
3'UTR of HOXA9
(miRNA target sites are highlighted)		 
>HOXA9|NM_152739|3'UTR
   1 TGCCATTTGGGCTTATTTAGAAAAAAGGGTAAGCTAGAGAGAAAAAGAAAGAACTGTCCGTCCCCCTTCCGCCTTCTCCC
  81 TTCTCTCACCCCCACCCTAGCCTCCACCATCCCCGCACAAAGCGGCTCTAAACCTCAGGCCACATCTTTTCCAAGGCAAA
 161 CCCTGTTCAGGCTGGCTCGTAGGCCTGCCGCTTTGATGGAGGAGGTATTGTAAGCTTTCCATTTTCTATAAGAAAAAGGA
 241 AAAGTTGAGGGGGGGGCATTAGTGCTGATAGCTGTGTGTGTTAGCTTGTATATATATTTTTAAAAATCTACCTGTTCCTG
 321 ACTTAAAACAAAAGGAAAGAAACTACCTTTTTATAATGCACAACTGTTGATGGTAGGCTGTATAGTTTTTAGTCTGTGTA
 401 GTTAATTTAATTTGCAGTTTGTGCGGCAGATTGCTCTGCCAAGATACTTGAACACTGTGTTTTATTGTGGTAATTATGTT
 481 TTGTGATTCAAACTTCTGTGTACTGGGTGATGCACCCATTGTGATTGTGGAAGATAGAATTCAATTTGAACTCAGGTTGT
 561 TTATGAGGGGAAAAAAACAGTTGCATAGAGTATAGCTCTGTAGTGGAATATGTCTTCTGTATAACTAGGCTGTTAACCTA
 641 TGATTGTAAAGTAGCTGTAAGAATTTCCCAGTGAAATAAAAAAAAATTTTAAGTGTTCTCGGGGATGCATAGATTCATCA
 721 TTTTCTCCACCTTAAAAATGCGGGCATTTAAGTCTGTCCATTATCTATATAGTCCTGTCTTGTCTATTGTATATATAATC
 801 TATATGATTAAAGAAAATATGCATAATCAGACAAGCTTGAATATTGTTTTTGCACCAGACGAACAGTGAGGAAATTCGGA
 881 GCTATACATATGTGCAGAAGGTTACTACCTAGGGTTTATGCTTAATTTTAATTGGAGGAAATGAATGCTGATTGTAACGG
 961 AGTTAATTTTATTGATAATAAATTATACACTATGAAACCGCCATTGGGCTACTGTAGATTTGTATCCTTGATGAATCTGG
1041 GGTTTCCATCAGACTGAACTTACACTGTATATTTTGCAATAGTTACCTCAAGGCCTACTGACCAAATTGTTGTGTTGAGA
1121 TGATATTTAACTTTTTGCCAAATAAAATATATTGATTCTTTTCTAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uauUCUCAGA-GGGGGACAUAUa 5'
             :|| | | :|::||||||| 
Target 5' agtGGAATATGTCTTCTGTATAa 3'
 602 - 624 155.00 -11.20
2 
miRNA  3' uauUCUCA---GAGGGGGACAUAUa 5'
             ||| |   ||: | ||||||| 
Target 5' atcAGACTGAACTTACACTGTATAt 3'
 1048 - 1072 155.00 -10.20
3 
miRNA  3' uauucucagaggggGACAUAUa 5'
                        ||||||| 
Target 5' ctgttgatggtaggCTGTATAg 3'
 364 - 385 140.00 -6.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31521339 27 COSMIC
COSN30477326 47 COSMIC
COSN30190832 50 COSMIC
COSN30188571 51 COSMIC
COSN28886045 53 COSMIC
COSN31491749 54 COSMIC
COSN31572579 55 COSMIC
COSN28797652 60 COSMIC
COSN30122179 60 COSMIC
COSN30182365 66 COSMIC
COSN14282671 71 COSMIC
COSN30180686 73 COSMIC
COSN30519602 82 COSMIC
COSN8872218 83 COSMIC
COSN26979202 89 COSMIC
COSN31499081 91 COSMIC
COSN19613215 94 COSMIC
COSN30187666 107 COSMIC
COSN30458657 114 COSMIC
COSN6877154 115 COSMIC
COSN30544838 125 COSMIC
COSN30190513 138 COSMIC
COSN31522683 154 COSMIC
COSN30155292 168 COSMIC
COSN1084338 179 COSMIC
COSN31517918 190 COSMIC
COSN18732194 235 COSMIC
COSN9984108 246 COSMIC
COSN31523995 285 COSMIC
COSN26563983 415 COSMIC
COSN19557723 418 COSMIC
COSN30173699 429 COSMIC
COSN21360157 481 COSMIC
COSN28772032 500 COSMIC
COSN20321846 569 COSMIC
COSN24296998 571 COSMIC
COSN6877153 632 COSMIC
COSN31579265 687 COSMIC
COSN31565395 701 COSMIC
COSN23016973 780 COSMIC
COSN31551394 797 COSMIC
COSN31536481 854 COSMIC
COSN28634413 933 COSMIC
COSN23834980 934 COSMIC
COSN31661419 954 COSMIC
COSN9984107 1041 COSMIC
COSN31568191 1122 COSMIC
COSN17182968 1154 COSMIC
COSN31486208 1156 COSMIC
rs10259620 933 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs751197378 1 dbSNP
rs757393231 3 dbSNP
rs575670067 4 dbSNP
rs373195636 7 dbSNP
rs1343041933 9 dbSNP
rs1276342581 11 dbSNP
rs763304806 12 dbSNP
rs1477715984 19 dbSNP
rs1233546102 20 dbSNP
rs1263772215 27 dbSNP
rs17472140 27 dbSNP
rs1369707179 28 dbSNP
rs1323560936 34 dbSNP
rs564237365 35 dbSNP
rs17500987 37 dbSNP
rs1255914178 41 dbSNP
rs772891366 42 dbSNP
rs771692391 47 dbSNP
rs1193520485 49 dbSNP
rs761410366 50 dbSNP
rs1037987085 59 dbSNP
rs938241459 63 dbSNP
rs1226070527 70 dbSNP
rs1173831608 71 dbSNP
rs1406128346 72 dbSNP
rs189587233 73 dbSNP
rs1367173896 75 dbSNP
rs1280035273 76 dbSNP
rs1382568994 76 dbSNP
rs1300255592 80 dbSNP
rs1051807454 82 dbSNP
rs7810502 83 dbSNP
rs903203776 86 dbSNP
rs1207444103 88 dbSNP
rs1270555678 90 dbSNP
rs970476251 90 dbSNP
rs915075553 91 dbSNP
rs542147750 93 dbSNP
rs1429444080 95 dbSNP
rs913626050 96 dbSNP
rs573134752 97 dbSNP
rs1307115304 98 dbSNP
rs1425066597 100 dbSNP
rs1366379910 102 dbSNP
rs552713334 105 dbSNP
rs981876744 107 dbSNP
rs988275681 109 dbSNP
rs957923556 111 dbSNP
rs559732995 114 dbSNP
rs1032584712 115 dbSNP
rs996761524 121 dbSNP
rs1350012454 123 dbSNP
rs1226639675 124 dbSNP
rs752234662 128 dbSNP
rs1290215518 129 dbSNP
rs1318059936 134 dbSNP
rs1413252032 137 dbSNP
rs1178269911 139 dbSNP
rs963892339 146 dbSNP
rs879460651 148 dbSNP
rs1489660101 149 dbSNP
rs866292228 158 dbSNP
rs1181861860 161 dbSNP
rs964007244 163 dbSNP
rs1017569381 165 dbSNP
rs1482486286 169 dbSNP
rs34248544 176 dbSNP
rs1426736709 178 dbSNP
rs1490622306 179 dbSNP
rs1179410142 182 dbSNP
rs1409473915 184 dbSNP
rs1419634082 189 dbSNP
rs1293461676 192 dbSNP
rs1218978247 195 dbSNP
rs1008824847 197 dbSNP
rs890555446 200 dbSNP
rs1047830842 205 dbSNP
rs1459237601 207 dbSNP
rs1007650059 211 dbSNP
rs953563449 212 dbSNP
rs545859037 214 dbSNP
rs576948299 222 dbSNP
rs185084360 229 dbSNP
rs537259388 231 dbSNP
rs553750216 235 dbSNP
rs1247179730 237 dbSNP
rs41316444 243 dbSNP
rs1274297208 244 dbSNP
rs1341050097 248 dbSNP
rs1181267181 249 dbSNP
rs1202542504 249 dbSNP
rs554957950 249 dbSNP
rs535353485 250 dbSNP
rs896723340 251 dbSNP
rs1163991681 252 dbSNP
rs1405309357 255 dbSNP
rs200749905 257 dbSNP
rs893680138 257 dbSNP
rs1172777619 258 dbSNP
rs1347211432 265 dbSNP
rs1355250337 269 dbSNP
rs1447389850 272 dbSNP
rs779788025 276 dbSNP
rs750779480 283 dbSNP
rs1349531147 293 dbSNP
rs1297368167 294 dbSNP
rs755864938 295 dbSNP
rs566327028 298 dbSNP
rs765846663 298 dbSNP
rs765701054 301 dbSNP
rs546588205 302 dbSNP
rs1253681363 313 dbSNP
rs1462613021 314 dbSNP
rs1159134701 319 dbSNP
rs918929213 334 dbSNP
rs1271584657 346 dbSNP
rs972102728 348 dbSNP
rs762038103 354 dbSNP
rs776708316 363 dbSNP
rs539510908 365 dbSNP
rs1414063842 368 dbSNP
rs1189086299 379 dbSNP
rs1174073573 383 dbSNP
rs1487919558 385 dbSNP
rs112752252 387 dbSNP
rs1320443793 400 dbSNP
rs1386977800 414 dbSNP
rs925146417 415 dbSNP
rs145028851 422 dbSNP
rs1271063567 424 dbSNP
rs368820871 424 dbSNP
rs879155081 425 dbSNP
rs375518739 426 dbSNP
rs1267397069 431 dbSNP
rs1204293772 434 dbSNP
rs181742818 442 dbSNP
rs1463437843 447 dbSNP
rs1217693447 448 dbSNP
rs967826461 454 dbSNP
rs1020374571 457 dbSNP
rs1431605489 458 dbSNP
rs1019467737 467 dbSNP
rs1480795659 468 dbSNP
rs1008082060 469 dbSNP
rs893155654 470 dbSNP
rs954762069 477 dbSNP
rs1026726921 478 dbSNP
rs1435359238 481 dbSNP
rs1300891587 487 dbSNP
rs78388547 491 dbSNP
rs993598904 494 dbSNP
rs1223597581 495 dbSNP
rs142964255 497 dbSNP
rs1459855482 502 dbSNP
rs528404917 507 dbSNP
rs768994163 511 dbSNP
rs1437340095 513 dbSNP
rs138384516 521 dbSNP
rs1002348742 523 dbSNP
rs1450800877 527 dbSNP
rs1219714563 536 dbSNP
rs1271309437 537 dbSNP
rs545798927 544 dbSNP
rs576888641 546 dbSNP
rs1046707549 551 dbSNP
rs1409788128 552 dbSNP
rs1471459341 554 dbSNP
rs563436500 557 dbSNP
rs551214152 562 dbSNP
rs775598584 566 dbSNP
rs1413584874 568 dbSNP
rs949659151 572 dbSNP
rs1403952983 576 dbSNP
rs1165789511 577 dbSNP
rs1320471834 578 dbSNP
rs897537594 581 dbSNP
rs771945665 585 dbSNP
rs1333449754 586 dbSNP
rs1036128433 588 dbSNP
rs189277058 592 dbSNP
rs941671668 604 dbSNP
rs1052493624 605 dbSNP
rs1293595110 612 dbSNP
rs1174312358 617 dbSNP
rs1432995503 640 dbSNP
rs1360464627 641 dbSNP
rs745834632 648 dbSNP
rs986336660 650 dbSNP
rs936443574 657 dbSNP
rs925006959 658 dbSNP
rs1183254800 659 dbSNP
rs574910782 662 dbSNP
rs1463160537 671 dbSNP
rs932273575 676 dbSNP
rs975235630 681 dbSNP
rs1203772047 686 dbSNP
rs12537391 687 dbSNP
rs1313887427 687 dbSNP
rs976622355 687 dbSNP
rs1167550374 688 dbSNP
rs1020763574 692 dbSNP
rs1462547122 701 dbSNP
rs990274133 709 dbSNP
rs555176822 710 dbSNP
rs1228005229 712 dbSNP
rs773251248 725 dbSNP
rs751924663 738 dbSNP
rs986714647 739 dbSNP
rs957588140 741 dbSNP
rs569929002 744 dbSNP
rs572718918 745 dbSNP
rs1244188684 751 dbSNP
rs1449231643 756 dbSNP
rs186436314 760 dbSNP
rs1187614533 763 dbSNP
rs905073956 764 dbSNP
rs1296523786 766 dbSNP
rs1024906920 767 dbSNP
rs1400821419 769 dbSNP
rs1013810770 774 dbSNP
rs539449195 779 dbSNP
rs1036506280 786 dbSNP
rs941821183 787 dbSNP
rs1404927247 790 dbSNP
rs1301624925 791 dbSNP
rs764532234 794 dbSNP
rs1355550973 799 dbSNP
rs972445398 802 dbSNP
rs1228376613 806 dbSNP
rs570502030 812 dbSNP
rs1447227437 819 dbSNP
rs963511788 821 dbSNP
rs758756193 825 dbSNP
rs1050009334 828 dbSNP
rs537921686 830 dbSNP
rs766684947 847 dbSNP
rs1445952551 852 dbSNP
rs1016378995 854 dbSNP
rs1376624030 855 dbSNP
rs1479161545 857 dbSNP
rs1178580503 859 dbSNP
rs1253970620 860 dbSNP
rs1429924602 861 dbSNP
rs1456596871 865 dbSNP
rs1286932838 867 dbSNP
rs145905865 869 dbSNP
rs1383040471 878 dbSNP
rs1323130665 880 dbSNP
rs370814748 881 dbSNP
rs149001266 882 dbSNP
rs1225435967 884 dbSNP
rs1025143709 888 dbSNP
rs1013841592 892 dbSNP
rs1237460974 893 dbSNP
rs568128306 895 dbSNP
rs1262905499 896 dbSNP
rs548387720 899 dbSNP
rs1486384351 900 dbSNP
rs892678285 905 dbSNP
rs1252914514 918 dbSNP
rs10259620 933 dbSNP
rs777287088 934 dbSNP
rs565976296 935 dbSNP
rs181737685 937 dbSNP
rs1268928240 952 dbSNP
rs552096220 953 dbSNP
rs1472247616 958 dbSNP
rs927366199 959 dbSNP
rs532370978 961 dbSNP
rs755828947 962 dbSNP
rs530685033 973 dbSNP
rs1454119878 974 dbSNP
rs1162366011 976 dbSNP
rs1363955735 982 dbSNP
rs1406940466 987 dbSNP
rs971402857 992 dbSNP
rs1024876124 998 dbSNP
rs1311206961 999 dbSNP
rs912435066 1000 dbSNP
rs1013530021 1006 dbSNP
rs1317965740 1014 dbSNP
rs752231477 1016 dbSNP
rs929922292 1018 dbSNP
rs1437519184 1022 dbSNP
rs1428258377 1025 dbSNP
rs1224213403 1036 dbSNP
rs1291932006 1041 dbSNP
rs1480020464 1051 dbSNP
rs1175483524 1052 dbSNP
rs190122610 1054 dbSNP
rs759592020 1059 dbSNP
rs1182775307 1066 dbSNP
rs887493602 1077 dbSNP
rs1426829214 1085 dbSNP
rs1164424418 1092 dbSNP
rs1050145581 1100 dbSNP
rs1458967413 1101 dbSNP
rs1366271746 1103 dbSNP
rs1374725665 1105 dbSNP
rs963735434 1109 dbSNP
rs35335761 1114 dbSNP
rs563289988 1114 dbSNP
rs1419542979 1116 dbSNP
rs1247795047 1123 dbSNP
rs901540701 1125 dbSNP
rs780882126 1131 dbSNP
rs1016263986 1150 dbSNP
rs1306494615 1153 dbSNP
rs1201843950 1154 dbSNP
rs1252501781 1165 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions hESCs (WA-09)
Disease 3205.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in SRR359787. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Lipchina I; Elkabetz Y; Hafner M; Sheridan et al., 2011, Genes & development.

Article - Lipchina I; Elkabetz Y; Hafner M; Sheridan et al.
- Genes & development, 2011
MicroRNAs are important regulators in many cellular processes, including stem cell self-renewal. Recent studies demonstrated their function as pluripotency factors with the capacity for somatic cell reprogramming. However, their role in human embryonic stem (ES) cells (hESCs) remains poorly understood, partially due to the lack of genome-wide strategies to identify their targets. Here, we performed comprehensive microRNA profiling in hESCs and in purified neural and mesenchymal derivatives. Using a combination of AGO cross-linking and microRNA perturbation experiments, together with computational prediction, we identified the targets of the miR-302/367 cluster, the most abundant microRNAs in hESCs. Functional studies identified novel roles of miR-302/367 in maintaining pluripotency and regulating hESC differentiation. We show that in addition to its role in TGF-beta signaling, miR-302/367 promotes bone morphogenetic protein (BMP) signaling by targeting BMP inhibitors TOB2, DAZAP2, and SLAIN1. This study broadens our understanding of microRNA function in hESCs and is a valuable resource for future studies in this area.
LinkOut: [PMID: 22012620]
CLIP-seq Support 1 for dataset SRR359787
Method / RBP PAR-CLIP / AGO2
Cell line / Condition hESCs (WA-09) / 4-thiouridine, RNase T1
Location of target site ENST00000396345.1 | 3UTR | CAACUGUUGAUGGUAGGCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 22012620 / SRX103431
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
114 hsa-miR-1185-1-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066415 TBK1 TANK binding kinase 1 2 4
MIRT073567 NR2F2 nuclear receptor subfamily 2 group F member 2 2 2
MIRT074516 USP1 ubiquitin specific peptidase 1 2 4
MIRT080576 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 6
MIRT086539 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 2
MIRT086547 MOB4 MOB family member 4, phocein 2 2
MIRT088684 EML4 echinoderm microtubule associated protein like 4 2 4
MIRT090811 MBNL1 muscleblind like splicing regulator 1 2 4
MIRT095500 PURA purine rich element binding protein A 2 2
MIRT109530 KLHL15 kelch like family member 15 2 6
MIRT109807 ZFX zinc finger protein, X-linked 2 2
MIRT117888 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT120273 GSK3B glycogen synthase kinase 3 beta 2 4
MIRT149892 LDLR low density lipoprotein receptor 2 2
MIRT178475 LCOR ligand dependent nuclear receptor corepressor 2 4
MIRT193445 RORA RAR related orphan receptor A 2 2
MIRT198527 DSG2 desmoglein 2 2 2
MIRT226427 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 2
MIRT227669 SET SET nuclear proto-oncogene 2 2
MIRT320405 HOXA9 homeobox A9 2 2
MIRT407774 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT439228 ZMIZ1 zinc finger MIZ-type containing 1 1 1
MIRT439312 VAT1L vesicle amine transport 1 like 1 1
MIRT439421 TMOD1 tropomodulin 1 1 1
MIRT439446 TMEM104 transmembrane protein 104 1 1
MIRT439524 STIM2 stromal interaction molecule 2 1 1
MIRT439612 SLC29A1 solute carrier family 29 member 1 (Augustine blood group) 1 1
MIRT439997 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 1 1
MIRT440017 PCSK1 proprotein convertase subtilisin/kexin type 1 1 1
MIRT440131 NCOA4 nuclear receptor coactivator 4 1 1
MIRT440311 LRRC1 leucine rich repeat containing 1 1 1
MIRT440475 IAPP islet amyloid polypeptide 1 1
MIRT440511 HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 1 1
MIRT440617 FOXA2 forkhead box A2 1 1
MIRT440666 FBXL16 F-box and leucine rich repeat protein 16 1 1
MIRT440705 ERO1LB endoplasmic reticulum oxidoreductase 1 beta 1 1
MIRT441007 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 1 1
MIRT441018 CAND1 cullin associated and neddylation dissociated 1 1 1
MIRT441062 C1orf43 chromosome 1 open reading frame 43 1 1
MIRT441209 ARCN1 archain 1 1 1
MIRT449461 HAT1 histone acetyltransferase 1 2 2
MIRT467104 SRI sorcin 2 2
MIRT468060 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 10
MIRT468476 SESN3 sestrin 3 2 4
MIRT473533 MAX MYC associated factor X 2 2
MIRT473852 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT474711 KIF13A kinesin family member 13A 2 6
MIRT481665 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT485120 SF3B3 splicing factor 3b subunit 3 2 2
MIRT493055 MTFR1 mitochondrial fission regulator 1 2 2
MIRT504258 C1orf147 chromosome 1 open reading frame 147 2 4
MIRT504361 ARID1B AT-rich interaction domain 1B 2 4
MIRT505748 SENP1 SUMO1/sentrin specific peptidase 1 2 8
MIRT506298 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2 6
MIRT508442 ZNF608 zinc finger protein 608 2 4
MIRT512782 COL4A3BP collagen type IV alpha 3 binding protein 2 2
MIRT520447 TSPAN2 tetraspanin 2 2 4
MIRT522133 NRBF2 nuclear receptor binding factor 2 2 6
MIRT522395 MYADM myeloid associated differentiation marker 2 4
MIRT523397 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2 4
MIRT523938 E2F8 E2F transcription factor 8 2 4
MIRT524349 CREB1 cAMP responsive element binding protein 1 2 2
MIRT524711 BRMS1L breast cancer metastasis-suppressor 1 like 2 4
MIRT525134 ZNF256 zinc finger protein 256 2 2
MIRT525710 DCAF12L2 DDB1 and CUL4 associated factor 12 like 2 2 2
MIRT531264 PPIL3 peptidylprolyl isomerase like 3 2 2
MIRT538844 BTG1 BTG anti-proliferation factor 1 2 2
MIRT541366 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT542093 KCNK10 potassium two pore domain channel subfamily K member 10 2 6
MIRT543770 RBM12B RNA binding motif protein 12B 2 4
MIRT543940 NCOA7 nuclear receptor coactivator 7 2 2
MIRT545150 GABRG1 gamma-aminobutyric acid type A receptor gamma1 subunit 2 2
MIRT545842 ZNF264 zinc finger protein 264 2 4
MIRT548057 GOLGA7 golgin A7 2 2
MIRT549242 ATXN1L ataxin 1 like 2 4
MIRT551829 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT552484 ZNF136 zinc finger protein 136 2 2
MIRT553663 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT554988 RAB39B RAB39B, member RAS oncogene family 2 2
MIRT555760 PCTP phosphatidylcholine transfer protein 2 2
MIRT556923 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 4
MIRT564991 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT566458 PGGT1B protein geranylgeranyltransferase type I subunit beta 2 2
MIRT566538 PANK3 pantothenate kinase 3 2 2
MIRT567732 DLX2 distal-less homeobox 2 2 2
MIRT570081 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 2
MIRT571735 RNF11 ring finger protein 11 2 2
MIRT573529 MDM2 MDM2 proto-oncogene 2 2
MIRT574459 RPS16 ribosomal protein S16 2 2
MIRT574992 Phka1 phosphorylase kinase alpha 1 2 3
MIRT576349 Pxdn peroxidasin 2 2
MIRT610196 CD99 CD99 molecule (Xg blood group) 2 4
MIRT612920 GPRIN3 GPRIN family member 3 2 2
MIRT615021 DUSP6 dual specificity phosphatase 6 2 2
MIRT623573 IRS1 insulin receptor substrate 1 2 2
MIRT624437 CASD1 CAS1 domain containing 1 2 2
MIRT628714 ZNF585A zinc finger protein 585A 2 2
MIRT639565 PCK1 phosphoenolpyruvate carboxykinase 1 2 4
MIRT641485 POLA2 DNA polymerase alpha 2, accessory subunit 2 2
MIRT641657 PAPOLG poly(A) polymerase gamma 2 2
MIRT642210 RUVBL2 RuvB like AAA ATPase 2 2 2
MIRT653010 STX7 syntaxin 7 2 2
MIRT656130 MSH6 mutS homolog 6 2 2
MIRT656893 KIAA2018 upstream transcription factor family member 3 2 2
MIRT660130 BRPF3 bromodomain and PHD finger containing 3 2 2
MIRT660855 AFAP1 actin filament associated protein 1 2 2
MIRT676843 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 3
MIRT681473 DIP2A disco interacting protein 2 homolog A 2 2
MIRT682253 RS1 retinoschisin 1 2 2
MIRT694296 COPB2 coatomer protein complex subunit beta 2 2 2
MIRT694401 ALDH1A3 aldehyde dehydrogenase 1 family member A3 2 2
MIRT705277 BACH1 BTB domain and CNC homolog 1 2 2
MIRT720833 C1orf52 chromosome 1 open reading frame 52 2 2
MIRT735713 SIRT1 sirtuin 1 2 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-1185-1 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-1185-1 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-1185-1-3p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-1185-1-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-1185-1-3p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-1185-1-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-1185-1-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-1185-1-3p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-1185-1-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-1185-1-3p Prednisone/Azathioprine/Methotrexate/Cyclophosphamide/Mycophenolate mofetil sensitive tissue (myasthenia gravis)
hsa-miR-1185-1-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-1185-1-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-1185-1-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-1185-1-3p Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-1185-1-3p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-1185-1-3p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-1185-1-3p Gemcitabine 60750 NSC613327 approved resistant cell line (MDA-231)
hsa-miR-1185-1-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-1185-1-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved resistant cell line (TOV-112D)

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