miRTarBase - #MIRT321046


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pre-miRNA Information
pre-miRNA hsa-mir-2115   
Genomic Coordinates chr3: 48316360 - 48316459
Description Homo sapiens miR-2115 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2115-3p
Sequence 58| CAUCAGAAUUCAUGGAGGCUAG |79
Evidence Experimental
Experiments 454
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN31490809 22 COSMIC
COSN31579735 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs543123304 18 dbSNP
rs1450988157 21 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol RAC1   
Synonyms MIG5, Rac-1, TC-25, p21-Rac1
Description Rac family small GTPase 1
Transcript NM_006908   
Other Transcripts NM_018890   
Expression
Putative miRNA Targets on RAC1
3'UTR of RAC1
(miRNA target sites are highlighted)		 
>RAC1|NM_006908|3'UTR
   1 ATGTCTCAGCCCCTCGTTCTTGGTCCTGTCCCTTGGAACCTTTGTACGCTTTGCTCAAAAAAAAACAAAAAAAAAAAACA
  81 AAAAAAAAAAACAACGGTGGAGCCTTCGCACTCAATGCCAACTTTTTGTTACAGATTAATTTTTCCATAAAACCATTTTT
 161 TGAACCAATCAGTAATTTTAAGGTTTTGTTTGTTCTAAATGTAAGAGTTCAGACTCACATTCTATTAAAATTTAGCCCTA
 241 AAATGACAAGCCTTCTTAAAGCCTTATTTTTCAAAAGCGCCCCCCCCATTCTTGTTCAGATTAAGAGTTGCCAAAATACC
 321 TTCTGAACTACACTGCATTGTTGTGCCGAGAACACCGAGCACTGAACTTTGCAAAGACCTTCGTCTTTGAGAAGACGGTA
 401 GCTTCTGCAGTTAGGAGGTGCAGACACTTGCTCTCCTATGTAGTTCTCAGATGCGTAAAGCAGAACAGCCTCCCGAATGA
 481 AGCGTTGCCATTGAACTCACCAGTGAGTTAGCAGCACGTGTTCCCGACATAACATTGTACTGTAATGGAGTGAGCGTAGC
 561 AGCTCAGCTCTTTGGATCAGTCTTTGTGATTTCATAGCGAGTTTTCTGACCAGCTTTTGCGGAGATTTTGAACAGAACTG
 641 CTATTTCCTCTAATGAAGAATTCTGTTTAGCTGTGGGTGTGCCGGGTGGGGTGTGTGTGATCAAAGGACAAAGACAGTAT
 721 TTTGACAAAATACGAAGTGGAGATTTACACTACATTGTACAAGGAATGAAAGTGTCACGGGTAAAAACTCTAAAAGGTTA
 801 ATTTCTGTCAAATGCAGTAGATGATGAAAGAAAGGTTGGTATTATCAGGAAATGTTTTCTTAAGCTTTTCCTTTCTCTTA
 881 CACCTGCCATGCCTCCCCAAATTGGGCATTTAATTCATCTTTAAACTGGTTGTTCTGTTAGTCGCTAACTTAGTAAGTGC
 961 TTTTCTTATAGAACCCCTTCTGACTGAGCAATATGCCTCCTTGTATTATAAAATCTTTCTGATAATGCATTAGAAGGTTT
1041 TTTTGTCGATTAGTAAAAGTGCTTTCCATGTTACTTTATTCAGAGCTAATAAGTGCTTTCCTTAGTTTTCTAGTAACTAG
1121 GTGTAAAAATCATGTGTTGCAGCTTTATAGTTTTTAAAATATTTTAGATAATTCTTAAACTATGAACCTTCTTAACATCA
1201 CTGTCTTGCCAGATTACCGACACTGTCACTTGACCAATACTGACCCTCTTTACCTCGCCCACGCGGACACACGCCTCCTG
1281 TAGTCGCTTTGCCTATTGATGTTCCTTTGGGTCTGTGAGGTTCTGTAAACTGTGCTAGTGCTGACGATGTTCTGTACAAC
1361 TTAACTCACTGGCGAGAATACAGCGTGGGACCCTTCAGCCACTACAACAGAATTTTTTAAATTGACAGTTGCAGAATTGT
1441 GGAGTGTTTTTACATTGATCTTTTGCTAATGCAATTAGCATTATGTTTTGCATGTATGACTTAATAAATCCTTGAATCAT
1521 A
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gauCGGAGGUAC--------UU---AAGACUAc 5'
             |||||| ||        ||   ||||||| 
Target 5' tatGCCTCCTTGTATTATAAAATCTTTCTGATa 3'
 992 - 1024 153.00 -14.76
2 
miRNA  3' gaucGGAGG-UA---CUUAAGACUAc 5'
              ||||: ||   |||||||| | 
Target 5' atttCCTCTAATGAAGAATTCTGTTt 3'
 643 - 668 134.00 -14.62
3 
miRNA  3' gauCGGAGGUA---CUU--AAGACUac 5'
             | :|:|||   ||:  ||||||  
Target 5' tgtGATTTCATAGCGAGTTTTCTGAcc 3'
 585 - 611 133.00 -7.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31505813 13 COSMIC
COSN30476381 52 COSMIC
COSN17432309 67 COSMIC
COSN20069945 67 COSMIC
COSN31535636 68 COSMIC
COSN30161944 76 COSMIC
COSN28729012 79 COSMIC
COSN16259428 80 COSMIC
COSN18731867 80 COSMIC
COSN20091511 81 COSMIC
COSN31532813 82 COSMIC
COSN20091512 84 COSMIC
COSN15605499 89 COSMIC
COSN8517428 90 COSMIC
COSN2533822 92 COSMIC
COSN20091513 93 COSMIC
COSN31518309 109 COSMIC
COSN26644067 129 COSMIC
COSN26640374 135 COSMIC
COSN31571666 279 COSMIC
COSN31532650 288 COSMIC
COSN6888601 315 COSMIC
COSN31550544 348 COSMIC
COSN31526506 349 COSMIC
COSN31579961 421 COSMIC
COSN31515916 476 COSMIC
COSN31521904 512 COSMIC
COSN28724803 520 COSMIC
COSN29044412 540 COSMIC
COSN26566795 907 COSMIC
COSN28727152 917 COSMIC
COSN20684842 974 COSMIC
COSN31555354 998 COSMIC
COSN8305666 1068 COSMIC
COSN15663032 1278 COSMIC
COSN31539651 1287 COSMIC
COSN22365392 1305 COSMIC
COSN22488813 1322 COSMIC
COSN24002372 1344 COSMIC
COSN31582515 1411 COSMIC
COSN31539327 1453 COSMIC
COSN24302246 1455 COSMIC
COSN31487449 1458 COSMIC
COSN31588302 1482 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1182478201 3 dbSNP
rs551209067 4 dbSNP
rs747446057 5 dbSNP
rs1416607213 11 dbSNP
rs34140491 12 dbSNP
rs774393501 15 dbSNP
rs970144899 16 dbSNP
rs201247499 17 dbSNP
rs780518597 20 dbSNP
rs866033200 22 dbSNP
rs916666566 23 dbSNP
rs555136675 24 dbSNP
rs775934071 28 dbSNP
rs566950515 31 dbSNP
rs771454358 31 dbSNP
rs748108279 33 dbSNP
rs757739241 35 dbSNP
rs1465138168 37 dbSNP
rs1279085861 48 dbSNP
rs1312724911 49 dbSNP
rs767081694 52 dbSNP
rs1381987413 53 dbSNP
rs1244028985 55 dbSNP
rs1377555716 55 dbSNP
rs1166104605 56 dbSNP
rs1304278830 56 dbSNP
rs1409488013 56 dbSNP
rs1417391229 56 dbSNP
rs1424239966 56 dbSNP
rs796691511 56 dbSNP
rs1231871206 57 dbSNP
rs1293190817 57 dbSNP
rs1484553436 57 dbSNP
rs763876723 57 dbSNP
rs867936578 57 dbSNP
rs1303653047 58 dbSNP
rs946552096 58 dbSNP
rs1043576518 59 dbSNP
rs1331046577 59 dbSNP
rs1352971070 59 dbSNP
rs1164068150 60 dbSNP
rs1401001083 60 dbSNP
rs1474120284 60 dbSNP
rs1182099611 61 dbSNP
rs1415607359 61 dbSNP
rs1465552463 61 dbSNP
rs1200035787 62 dbSNP
rs1230785604 62 dbSNP
rs1457781539 62 dbSNP
rs1212290485 63 dbSNP
rs1273141109 63 dbSNP
rs1323888791 63 dbSNP
rs200708039 64 dbSNP
rs756522639 64 dbSNP
rs773357267 64 dbSNP
rs1311715857 65 dbSNP
rs571090671 65 dbSNP
rs1370289499 66 dbSNP
rs59685280 66 dbSNP
rs1456277019 67 dbSNP
rs2303366 67 dbSNP
rs902427752 67 dbSNP
rs1165269331 68 dbSNP
rs749525692 68 dbSNP
rs1266519060 69 dbSNP
rs1439775798 69 dbSNP
rs999372877 69 dbSNP
rs1215588269 70 dbSNP
rs908346557 70 dbSNP
rs1301414312 71 dbSNP
rs1369699677 71 dbSNP
rs1388588575 71 dbSNP
rs1059223 72 dbSNP
rs1293989720 72 dbSNP
rs1394094306 73 dbSNP
rs1434377732 73 dbSNP
rs764941203 73 dbSNP
rs1268696847 74 dbSNP
rs567222182 74 dbSNP
rs577869801 74 dbSNP
rs1485101417 75 dbSNP
rs538417726 75 dbSNP
rs932429182 75 dbSNP
rs1217790976 76 dbSNP
rs1278430350 76 dbSNP
rs35359875 76 dbSNP
rs1312805789 77 dbSNP
rs557217236 77 dbSNP
rs1188189625 78 dbSNP
rs1008439681 79 dbSNP
rs61124997 79 dbSNP
rs1170377612 80 dbSNP
rs1377633444 80 dbSNP
rs1400344304 80 dbSNP
rs1467164933 80 dbSNP
rs1477162136 80 dbSNP
rs2303367 80 dbSNP
rs1426407280 81 dbSNP
rs866074948 81 dbSNP
rs1053799259 82 dbSNP
rs1225323747 82 dbSNP
rs891935382 83 dbSNP
rs951809960 83 dbSNP
rs1354544439 84 dbSNP
rs372877887 84 dbSNP
rs1397360010 85 dbSNP
rs560677179 85 dbSNP
rs1297169960 86 dbSNP
rs561883842 86 dbSNP
rs1403112556 87 dbSNP
rs1001610002 88 dbSNP
rs1475086944 89 dbSNP
rs1017136867 90 dbSNP
rs1424681356 90 dbSNP
rs777572979 90 dbSNP
rs1491166978 91 dbSNP
rs960317646 91 dbSNP
rs1491572747 92 dbSNP
rs992059776 92 dbSNP
rs1015912154 93 dbSNP
rs1263518009 96 dbSNP
rs961340166 96 dbSNP
rs1173614344 97 dbSNP
rs1156644036 104 dbSNP
rs1340740963 105 dbSNP
rs973896905 108 dbSNP
rs1443974023 109 dbSNP
rs1425157281 111 dbSNP
rs919792249 112 dbSNP
rs1320741095 116 dbSNP
rs960952155 122 dbSNP
rs16871368 128 dbSNP
rs1435307273 131 dbSNP
rs932355591 133 dbSNP
rs1165399679 140 dbSNP
rs1409664621 155 dbSNP
rs1363467193 156 dbSNP
rs1176964405 166 dbSNP
rs1362319411 166 dbSNP
rs1442539875 167 dbSNP
rs370215539 183 dbSNP
rs1193073455 192 dbSNP
rs368834331 196 dbSNP
rs36030054 197 dbSNP
rs1287605486 198 dbSNP
rs1211469159 201 dbSNP
rs990877710 202 dbSNP
rs1356737276 208 dbSNP
rs985208678 209 dbSNP
rs912208125 211 dbSNP
rs1355386383 214 dbSNP
rs1344269759 220 dbSNP
rs761465378 221 dbSNP
rs764853005 223 dbSNP
rs1286026073 224 dbSNP
rs1329643086 236 dbSNP
rs1208272882 238 dbSNP
rs1052818282 247 dbSNP
rs1246440211 252 dbSNP
rs892024550 253 dbSNP
rs947704541 254 dbSNP
rs1043200445 255 dbSNP
rs1384623428 258 dbSNP
rs1157098780 262 dbSNP
rs539906640 267 dbSNP
rs1421818528 275 dbSNP
rs906050171 279 dbSNP
rs1001536228 280 dbSNP
rs201711136 280 dbSNP
rs923745507 280 dbSNP
rs935185168 280 dbSNP
rs1040653467 282 dbSNP
rs901796664 283 dbSNP
rs1286252667 285 dbSNP
rs1469868891 286 dbSNP
rs1035748704 287 dbSNP
rs114923537 288 dbSNP
rs1402205304 293 dbSNP
rs1361467748 294 dbSNP
rs9374 295 dbSNP
rs1014963656 296 dbSNP
rs1160827940 297 dbSNP
rs1427286948 298 dbSNP
rs1413068445 300 dbSNP
rs1478352671 303 dbSNP
rs961581808 303 dbSNP
rs1014695653 306 dbSNP
rs961505468 308 dbSNP
rs1489118656 309 dbSNP
rs1263491403 315 dbSNP
rs1457054129 317 dbSNP
rs973993462 324 dbSNP
rs1208911158 326 dbSNP
rs1440214794 331 dbSNP
rs1026780077 333 dbSNP
rs953876837 334 dbSNP
rs950958927 337 dbSNP
rs1280202185 338 dbSNP
rs1157937761 339 dbSNP
rs994350428 342 dbSNP
rs985181066 348 dbSNP
rs1220873646 349 dbSNP
rs1387975330 350 dbSNP
rs1292920269 355 dbSNP
rs12977 357 dbSNP
rs569519190 358 dbSNP
rs943826535 363 dbSNP
rs916605897 368 dbSNP
rs751417028 369 dbSNP
rs1434158488 375 dbSNP
rs1281217216 378 dbSNP
rs988881290 379 dbSNP
rs1227623151 380 dbSNP
rs979450314 383 dbSNP
rs1181057782 384 dbSNP
rs912933812 386 dbSNP
rs947608448 395 dbSNP
rs1238815338 397 dbSNP
rs1266470787 398 dbSNP
rs1337277872 403 dbSNP
rs34625328 405 dbSNP
rs1256751467 411 dbSNP
rs927443723 414 dbSNP
rs1319193151 422 dbSNP
rs937495638 424 dbSNP
rs539108343 426 dbSNP
rs1381677312 427 dbSNP
rs1449973769 427 dbSNP
rs1284949732 431 dbSNP
rs895883866 432 dbSNP
rs1374668150 433 dbSNP
rs1184521662 434 dbSNP
rs1005000440 436 dbSNP
rs1036738067 438 dbSNP
rs899167662 439 dbSNP
rs1400939509 440 dbSNP
rs781547027 446 dbSNP
rs1026917635 455 dbSNP
rs548626083 456 dbSNP
rs1163439153 462 dbSNP
rs836552 468 dbSNP
rs1235888347 469 dbSNP
rs1179965931 473 dbSNP
rs1163513848 476 dbSNP
rs1246614964 479 dbSNP
rs887414228 484 dbSNP
rs1019483691 485 dbSNP
rs941685798 490 dbSNP
rs534300530 491 dbSNP
rs1311646583 496 dbSNP
rs1351770504 496 dbSNP
rs965495464 500 dbSNP
rs988589302 503 dbSNP
rs1447573236 506 dbSNP
rs774626708 510 dbSNP
rs1374034015 511 dbSNP
rs559042866 515 dbSNP
rs1434072990 518 dbSNP
rs897613835 519 dbSNP
rs994738680 522 dbSNP
rs1378064243 524 dbSNP
rs769811766 526 dbSNP
rs1439718949 527 dbSNP
rs576097646 528 dbSNP
rs1035225811 529 dbSNP
rs968376081 530 dbSNP
rs1247718447 531 dbSNP
rs978425027 533 dbSNP
rs1216343303 542 dbSNP
rs896713851 545 dbSNP
rs1245748203 551 dbSNP
rs1012478753 552 dbSNP
rs1240994553 556 dbSNP
rs927529916 557 dbSNP
rs967980661 558 dbSNP
rs937631392 565 dbSNP
rs979440387 571 dbSNP
rs1303575855 578 dbSNP
rs777835910 582 dbSNP
rs1283829821 583 dbSNP
rs1057481186 595 dbSNP
rs749756940 599 dbSNP
rs917431685 600 dbSNP
rs1173331757 601 dbSNP
rs11540454 607 dbSNP
rs956839787 614 dbSNP
rs940731630 621 dbSNP
rs1036465748 622 dbSNP
rs1477018767 623 dbSNP
rs1275932473 625 dbSNP
rs1265654864 626 dbSNP
rs899135374 631 dbSNP
rs571397435 640 dbSNP
rs1050442005 655 dbSNP
rs1254406866 655 dbSNP
rs1259998381 662 dbSNP
rs1313930856 667 dbSNP
rs1217815281 669 dbSNP
rs1283790828 669 dbSNP
rs889704483 674 dbSNP
rs1338058947 680 dbSNP
rs774560309 684 dbSNP
rs538816597 685 dbSNP
rs1187743508 686 dbSNP
rs557006972 687 dbSNP
rs1384247787 690 dbSNP
rs1300612651 691 dbSNP
rs1467116114 691 dbSNP
rs1407506599 699 dbSNP
rs965246899 703 dbSNP
rs760010477 707 dbSNP
rs1426158556 712 dbSNP
rs141377991 714 dbSNP
rs36059496 714 dbSNP
rs897558664 715 dbSNP
rs1020047318 716 dbSNP
rs551435881 717 dbSNP
rs1057305364 726 dbSNP
rs1483596324 727 dbSNP
rs575473267 734 dbSNP
rs1428976751 735 dbSNP
rs1012370229 746 dbSNP
rs543502045 749 dbSNP
rs968461700 757 dbSNP
rs1023838589 760 dbSNP
rs904145449 761 dbSNP
rs542485609 768 dbSNP
rs1397302393 769 dbSNP
rs1333745731 772 dbSNP
rs926992932 779 dbSNP
rs1230668599 780 dbSNP
rs1168902265 781 dbSNP
rs112102014 783 dbSNP
rs956940129 791 dbSNP
rs976163614 793 dbSNP
rs1167095199 798 dbSNP
rs1341583175 802 dbSNP
rs554159470 806 dbSNP
rs1237706163 812 dbSNP
rs1176848828 814 dbSNP
rs1456421406 815 dbSNP
rs879032072 819 dbSNP
rs200099418 820 dbSNP
rs60010350 820 dbSNP
rs1224489002 824 dbSNP
rs776663992 826 dbSNP
rs1355334590 827 dbSNP
rs572460244 831 dbSNP
rs569685951 835 dbSNP
rs556508707 838 dbSNP
rs768175198 844 dbSNP
rs1307983285 845 dbSNP
rs917381640 846 dbSNP
rs1190139511 848 dbSNP
rs539986428 849 dbSNP
rs770607361 853 dbSNP
rs1330094777 854 dbSNP
rs1386568208 858 dbSNP
rs1388948258 862 dbSNP
rs1295635252 866 dbSNP
rs1448357345 869 dbSNP
rs1425604570 871 dbSNP
rs1379880929 872 dbSNP
rs1156986858 876 dbSNP
rs1441573006 880 dbSNP
rs972669602 882 dbSNP
rs1365500799 893 dbSNP
rs909122683 897 dbSNP
rs373871719 901 dbSNP
rs1490425151 917 dbSNP
rs1379363573 929 dbSNP
rs6951997 932 dbSNP
rs1171846233 935 dbSNP
rs1050409572 944 dbSNP
rs556311804 945 dbSNP
rs938361852 946 dbSNP
rs532631334 950 dbSNP
rs1437467008 952 dbSNP
rs761562585 954 dbSNP
rs1321505488 957 dbSNP
rs1360160056 965 dbSNP
rs544771570 970 dbSNP
rs199612194 971 dbSNP
rs1421600954 976 dbSNP
rs1385688207 978 dbSNP
rs915682651 979 dbSNP
rs1172055805 985 dbSNP
rs1433051231 985 dbSNP
rs1477696887 986 dbSNP
rs759631104 988 dbSNP
rs1201342249 998 dbSNP
rs1480616981 1014 dbSNP
rs1045235905 1016 dbSNP
rs1313364067 1018 dbSNP
rs1448353180 1024 dbSNP
rs1040986189 1027 dbSNP
rs900974469 1029 dbSNP
rs139209076 1032 dbSNP
rs35850876 1032 dbSNP
rs1276557612 1038 dbSNP
rs1285695887 1038 dbSNP
rs1340220591 1038 dbSNP
rs562915357 1038 dbSNP
rs530441112 1047 dbSNP
rs904271163 1048 dbSNP
rs999907435 1049 dbSNP
rs1210158005 1053 dbSNP
rs1400018956 1057 dbSNP
rs1248278864 1059 dbSNP
rs1178416183 1067 dbSNP
rs1464027614 1069 dbSNP
rs1422723721 1083 dbSNP
rs892432313 1087 dbSNP
rs1033936578 1090 dbSNP
rs958384191 1102 dbSNP
rs1242313405 1104 dbSNP
rs1186257587 1114 dbSNP
rs1186202343 1122 dbSNP
rs1440160130 1131 dbSNP
rs761242391 1132 dbSNP
rs1204806407 1134 dbSNP
rs1317829996 1140 dbSNP
rs997928641 1149 dbSNP
rs1340383961 1151 dbSNP
rs1433646584 1151 dbSNP
rs993458281 1155 dbSNP
rs1337454632 1160 dbSNP
rs1342281971 1160 dbSNP
rs1453366164 1162 dbSNP
rs183208469 1169 dbSNP
rs1168330132 1172 dbSNP
rs1411398393 1176 dbSNP
rs976621022 1176 dbSNP
rs1162213396 1177 dbSNP
rs1471533746 1182 dbSNP
rs1007387727 1183 dbSNP
rs1016130940 1188 dbSNP
rs1457742662 1188 dbSNP
rs1236862963 1204 dbSNP
rs1207100963 1209 dbSNP
rs1024546694 1213 dbSNP
rs749974320 1219 dbSNP
rs566872985 1220 dbSNP
rs762960704 1221 dbSNP
rs766381651 1226 dbSNP
rs1361851231 1229 dbSNP
rs919168444 1231 dbSNP
rs1239485347 1236 dbSNP
rs959728138 1238 dbSNP
rs1296340679 1244 dbSNP
rs930681808 1246 dbSNP
rs112118570 1247 dbSNP
rs1295420808 1249 dbSNP
rs1322636716 1255 dbSNP
rs1403317750 1257 dbSNP
rs35197465 1257 dbSNP
rs1386678327 1258 dbSNP
rs910534664 1262 dbSNP
rs944738632 1263 dbSNP
rs1438492756 1264 dbSNP
rs1040807424 1265 dbSNP
rs901085296 1266 dbSNP
rs34144836 1267 dbSNP
rs554210282 1267 dbSNP
rs1352659166 1269 dbSNP
rs1246554258 1273 dbSNP
rs936849545 1274 dbSNP
rs1052662573 1278 dbSNP
rs1292711862 1280 dbSNP
rs1328126722 1281 dbSNP
rs1213234159 1282 dbSNP
rs368738077 1283 dbSNP
rs1266627882 1286 dbSNP
rs373918915 1287 dbSNP
rs1190505177 1288 dbSNP
rs945987849 1293 dbSNP
rs997520612 1294 dbSNP
rs754860731 1296 dbSNP
rs1473432147 1309 dbSNP
rs1402851907 1310 dbSNP
rs889188425 1312 dbSNP
rs1303308175 1318 dbSNP
rs1182717754 1322 dbSNP
rs760743675 1325 dbSNP
rs1418571799 1331 dbSNP
rs904366046 1332 dbSNP
rs1007626742 1336 dbSNP
rs1420246919 1336 dbSNP
rs999877880 1338 dbSNP
rs780862406 1344 dbSNP
rs894244138 1347 dbSNP
rs1350497784 1350 dbSNP
rs527680624 1351 dbSNP
rs1457486431 1352 dbSNP
rs1292265567 1358 dbSNP
rs1269877403 1359 dbSNP
rs14627 1360 dbSNP
rs1410817951 1363 dbSNP
rs1487423839 1363 dbSNP
rs1262636807 1366 dbSNP
rs570907419 1374 dbSNP
rs1026221013 1375 dbSNP
rs188629172 1377 dbSNP
rs972734797 1379 dbSNP
rs550772240 1385 dbSNP
rs992486547 1386 dbSNP
rs1022562528 1389 dbSNP
rs952210641 1394 dbSNP
rs1290168510 1397 dbSNP
rs1453790059 1400 dbSNP
rs1359124840 1401 dbSNP
rs986187329 1405 dbSNP
rs1174818794 1408 dbSNP
rs1471169778 1409 dbSNP
rs1321772252 1411 dbSNP
rs910628001 1412 dbSNP
rs1220239687 1419 dbSNP
rs1476987728 1428 dbSNP
rs978447791 1430 dbSNP
rs34737129 1431 dbSNP
rs976099912 1436 dbSNP
rs1482946100 1439 dbSNP
rs913897124 1443 dbSNP
rs572403740 1445 dbSNP
rs1205798690 1447 dbSNP
rs988749025 1449 dbSNP
rs1250710399 1454 dbSNP
rs1041635030 1455 dbSNP
rs1305427550 1458 dbSNP
rs146672210 1467 dbSNP
rs1414855276 1468 dbSNP
rs191733007 1475 dbSNP
rs1377740353 1480 dbSNP
rs1162845179 1482 dbSNP
rs1055575581 1493 dbSNP
rs1455116963 1494 dbSNP
rs894224045 1497 dbSNP
rs1392120508 1501 dbSNP
rs762280506 1505 dbSNP
rs1170477466 1510 dbSNP
rs183171680 1511 dbSNP
rs1307997335 1518 dbSNP
rs187853103 1520 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 5879.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000348035.4 | 3UTR | UAUUAUAAAAUCUUUCUGAUAAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000348035.4 | 3UTR | UAUUAUAAAAUCUUUCUGAUAAUGCAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LIHC 0.78 0.11 0.400 0.3 4 Click to see details
BRCA -0.183 0.16 -0.041 0.41 31 Click to see details
STAD 0.719 0.24 0.500 0.33 3 Click to see details
BLCA -0.333 0.26 -0.086 0.44 6 Click to see details
LUSC 0.167 0.28 0.118 0.34 15 Click to see details
UCEC 0.457 0.35 0.500 0.33 3 Click to see details
HNSC -0.086 0.39 -0.024 0.47 14 Click to see details
HNSC -0.086 0.39 -0.024 0.47 14 Click to see details
HNSC -0.086 0.39 -0.024 0.47 14 Click to see details
HNSC -0.086 0.39 -0.024 0.47 14 Click to see details
HNSC -0.086 0.39 -0.024 0.47 14 Click to see details
HNSC -0.086 0.39 -0.024 0.47 14 Click to see details
HNSC -0.086 0.39 -0.024 0.47 14 Click to see details
80 hsa-miR-2115-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT057089 DDIT4 DNA damage inducible transcript 4 2 2
MIRT071216 FCF1 FCF1, rRNA-processing protein 2 2
MIRT226901 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT235961 BACH1 BTB domain and CNC homolog 1 2 2
MIRT294569 ZNF460 zinc finger protein 460 2 4
MIRT321046 RAC1 Rac family small GTPase 1 2 4
MIRT359666 NUS1 NUS1 dehydrodolichyl diphosphate synthase subunit 2 8
MIRT366451 KLHL15 kelch like family member 15 2 2
MIRT405375 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT441794 TCEAL5 transcription elongation factor A like 5 2 2
MIRT443295 TCEAL3 transcription elongation factor A like 3 2 2
MIRT455275 DDX39B DExD-box helicase 39B 2 2
MIRT458523 C5orf22 chromosome 5 open reading frame 22 2 2
MIRT464960 TWIST1 twist family bHLH transcription factor 1 2 2
MIRT466848 STX6 syntaxin 6 2 2
MIRT469252 RHOB ras homolog family member B 2 2
MIRT469825 RAB14 RAB14, member RAS oncogene family 2 4
MIRT470047 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT471420 PDP2 pyruvate dehyrogenase phosphatase catalytic subunit 2 2 2
MIRT472024 NPM1 nucleophosmin 1 2 2
MIRT484156 CENPN centromere protein N 2 2
MIRT485490 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT490462 PROSER2 proline and serine rich 2 2 2
MIRT493069 MTCH1 mitochondrial carrier 1 2 2
MIRT493573 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 8
MIRT494919 NDUFC2-KCTD14 NDUFC2-KCTD14 readthrough 2 2
MIRT500439 ZMAT3 zinc finger matrin-type 3 2 2
MIRT500931 SRPR SRP receptor alpha subunit 2 4
MIRT501551 POC1B-GALNT4 POC1B-GALNT4 readthrough 2 2
MIRT501809 NEURL1B neuralized E3 ubiquitin protein ligase 1B 2 2
MIRT502415 GALNT4 polypeptide N-acetylgalactosaminyltransferase 4 2 2
MIRT506504 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 2
MIRT507861 CCNE2 cyclin E2 2 2
MIRT510511 YOD1 YOD1 deubiquitinase 2 6
MIRT516073 RAB42 RAB42, member RAS oncogene family 2 2
MIRT519030 KYNU kynureninase 2 6
MIRT521762 PPIL1 peptidylprolyl isomerase like 1 2 4
MIRT522898 KCNJ3 potassium voltage-gated channel subfamily J member 3 2 4
MIRT527370 MGARP mitochondria localized glutamic acid rich protein 2 2
MIRT530691 C8orf46 chromosome 8 open reading frame 46 2 2
MIRT530867 TRUB1 TruB pseudouridine synthase family member 1 2 2
MIRT531832 MTPAP mitochondrial poly(A) polymerase 2 4
MIRT533035 ZBTB5 zinc finger and BTB domain containing 5 2 2
MIRT533165 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT533464 TRIM71 tripartite motif containing 71 2 2
MIRT534331 SHCBP1 SHC binding and spindle associated 1 2 2
MIRT539372 ADSS adenylosuccinate synthase 2 6
MIRT545951 ZBTB10 zinc finger and BTB domain containing 10 2 2
MIRT553283 TSR1 TSR1, ribosome maturation factor 2 2
MIRT553532 TMEM185B transmembrane protein 185B 2 4
MIRT556480 LIPA lipase A, lysosomal acid type 2 2
MIRT556975 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT557697 GATA6 GATA binding protein 6 2 2
MIRT558901 CCDC58 coiled-coil domain containing 58 2 2
MIRT559224 BLMH bleomycin hydrolase 2 2
MIRT559827 SLPI secretory leukocyte peptidase inhibitor 2 2
MIRT563435 SLC3A2 solute carrier family 3 member 2 2 2
MIRT569270 PCDH11X protocadherin 11 X-linked 2 2
MIRT571386 JKAMP JNK1/MAPK8-associated membrane protein 2 2
MIRT572567 AFF1 AF4/FMR2 family member 1 2 2
MIRT610400 AR androgen receptor 2 2
MIRT611058 ZNF621 zinc finger protein 621 2 2
MIRT635118 TMEM233 transmembrane protein 233 2 2
MIRT641617 DEFB118 defensin beta 118 2 2
MIRT642146 CHORDC1 cysteine and histidine rich domain containing 1 2 2
MIRT647295 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT648155 MPLKIP M-phase specific PLK1 interacting protein 2 2
MIRT652780 TENM3 teneurin transmembrane protein 3 2 2
MIRT657356 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT658718 ELN elastin 2 2
MIRT662441 RALGAPA1 Ral GTPase activating protein catalytic alpha subunit 1 2 2
MIRT665302 ZBTB38 zinc finger and BTB domain containing 38 2 2
MIRT699898 RUNX1 runt related transcription factor 1 2 2
MIRT700921 PDS5A PDS5 cohesin associated factor A 2 2
MIRT700992 PDE3A phosphodiesterase 3A 2 2
MIRT707397 DCAF4L1 DDB1 and CUL4 associated factor 4 like 1 2 2
MIRT711895 INSIG2 insulin induced gene 2 2 2
MIRT712072 XRCC5 X-ray repair cross complementing 5 2 2
MIRT716121 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT724470 SMAD2 SMAD family member 2 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2115 Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-mir-2115 Decitabine 451668 approved sensitive tissue (esopheageal cancer)
hsa-miR-2115-3p Imatinib 5291 NSC743414 approved resistant High Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-2115-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-2115-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-2115-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-2115-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)

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