miRTarBase - #MIRT325704


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pre-miRNA Information
pre-miRNA hsa-mir-124-1   
Genomic Coordinates chr8: 9903388 - 9903472
Description Homo sapiens miR-124-1 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-124-2   
Genomic Coordinates chr8: 64379149 - 64379257
Description Homo sapiens miR-124-2 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-mir-124-3   
Genomic Coordinates chr20: 63178500 - 63178586
Description Homo sapiens miR-124-3 stem-loop
Comment miR-124 was first identified by cloning studies in mouse . The 5' end of the miRNA may be offset with respect to previous annotations.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-124-5p
Sequence 14| CGUGUUCACAGCGGACCUUGAU |35
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 8 8 + 64379180 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1280076135 1 dbSNP
rs775858016 4 dbSNP
rs760972715 7 dbSNP
rs1334649236 11 dbSNP
rs1160219511 12 dbSNP
rs764591061 12 dbSNP
rs1261326747 13 dbSNP
rs1344491363 20 dbSNP
rs1340798465 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Biomarker Information
Biomarker ID Name Type Discovered From Mode Level Source Testing Methods
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Increase Plasma Polymerase chain reaction
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Decrease Neuron Reverse transcription-polymerase chain reaction
B28CWB miR-124 Safety Biomarker (SAF); Monitoring Biomarker (MOI) Clinical/Experimental Data Expression Decrease Peripheral blood mononuclear cell Reverse transcription-polymerase chain reaction
Gene Information
Gene Symbol CSTF2   
Synonyms CstF-64
Description cleavage stimulation factor subunit 2
Transcript NM_001325   
Expression
Putative miRNA Targets on CSTF2
3'UTR of CSTF2
(miRNA target sites are highlighted)		 
>CSTF2|NM_001325|3'UTR
   1 TAGGTTTTCAAAAATACCTGGCAAGAAATCTGGAAATTCTATAATTTTGTTGAAATATTGAAAAAAGATGACCTGCATCC
  81 TAACCCTTGAATGACTCAAATCAGTGCCAGGTGGAGGACTCCCATCACCTTCTCTCAGAACAAAATCACTTCATTTTATT
 161 GTCTTAGTTTGTATATTTTCTGTGACTTGAAATAAACTTTGAACACAATTTTAGTACACTGCAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uaguuccaggcGACACUUGUGc 5'
                     || ||||||| 
Target 5' cttgaaataaaCTTTGAACACa 3'
 186 - 207 147.00 -9.00
2 
miRNA  3' uaguuccAGGCGACACUUGUgc 5'
                 |:| ||  |||||  
Target 5' catcaccTTCTCTCAGAACAaa 3'
 123 - 144 103.00 -6.70
3 
miRNA  3' uaguuccaggcgacaCUUGUGc 5'
                         ||: || 
Target 5' aatcagtgccaggtgGAGGACt 3'
 99 - 120 72.00 -11.00
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs369509310 12 dbSNP
rs1467080043 14 dbSNP
rs759544335 14 dbSNP
rs765184423 16 dbSNP
rs1453722104 32 dbSNP
rs775371026 34 dbSNP
rs1195559336 42 dbSNP
rs768698797 46 dbSNP
rs1205089754 52 dbSNP
rs776755593 80 dbSNP
rs1000459783 89 dbSNP
rs1249913076 89 dbSNP
rs1001323715 98 dbSNP
rs1018011425 99 dbSNP
rs1254621016 111 dbSNP
rs1234065869 134 dbSNP
rs1339204170 138 dbSNP
rs1205959815 153 dbSNP
rs899595610 156 dbSNP
rs1482691132 159 dbSNP
rs1333412579 161 dbSNP
rs761917441 164 dbSNP
rs13340756 165 dbSNP
rs1398269432 176 dbSNP
rs1310814785 183 dbSNP
rs773358306 191 dbSNP
rs1052450359 211 dbSNP
rs140575080 230 dbSNP
rs1468544604 248 dbSNP
rs1363288635 268 dbSNP
rs1423055189 269 dbSNP
rs1218445141 275 dbSNP
rs375237575 282 dbSNP
rs188516894 289 dbSNP
rs1172555092 294 dbSNP
rs1373866483 303 dbSNP
rs751909555 320 dbSNP
rs1254391226 329 dbSNP
rs1465730631 339 dbSNP
rs1486182248 343 dbSNP
rs542524482 344 dbSNP
rs1282920028 348 dbSNP
rs1227524824 349 dbSNP
rs1278442460 358 dbSNP
rs1025259422 361 dbSNP
rs1377028474 371 dbSNP
rs1337141769 397 dbSNP
rs1291007987 408 dbSNP
rs1413791982 417 dbSNP
rs1375772241 425 dbSNP
rs969610486 428 dbSNP
rs1398875880 431 dbSNP
rs954924412 456 dbSNP
rs181059913 457 dbSNP
rs1015169719 467 dbSNP
rs767981484 475 dbSNP
rs1415806108 484 dbSNP
rs1215829821 490 dbSNP
rs1475667295 491 dbSNP
rs1260038595 498 dbSNP
rs963560699 513 dbSNP
rs144795909 514 dbSNP
rs528098972 530 dbSNP
rs780432044 533 dbSNP
rs1311317065 537 dbSNP
rs1352165703 548 dbSNP
rs937424730 549 dbSNP
rs2213514 558 dbSNP
rs374951167 559 dbSNP
rs755141815 564 dbSNP
rs1041636990 566 dbSNP
rs1294863630 580 dbSNP
rs951836554 581 dbSNP
rs1325660538 589 dbSNP
rs984907496 596 dbSNP
rs904467670 624 dbSNP
rs781422730 625 dbSNP
rs1402383141 636 dbSNP
rs1211990211 688 dbSNP
rs1392308920 697 dbSNP
rs1164380016 700 dbSNP
rs1462161743 705 dbSNP
rs1263124848 727 dbSNP
rs1420347505 729 dbSNP
rs778227916 733 dbSNP
rs935822206 734 dbSNP
rs1039963204 737 dbSNP
rs1487558690 750 dbSNP
rs1243087214 756 dbSNP
rs899544018 757 dbSNP
rs923232865 761 dbSNP
rs1250591995 765 dbSNP
rs1262503691 766 dbSNP
rs1335046698 779 dbSNP
rs1274604996 789 dbSNP
rs186557162 790 dbSNP
rs998353935 797 dbSNP
rs868786555 814 dbSNP
rs1397077856 819 dbSNP
rs1368785971 835 dbSNP
rs1325270419 844 dbSNP
rs1441799653 849 dbSNP
rs1396812748 850 dbSNP
rs1168553444 855 dbSNP
rs886772771 857 dbSNP
rs913364117 861 dbSNP
rs1420652005 864 dbSNP
rs1435128445 880 dbSNP
rs1453083760 887 dbSNP
rs1194822421 888 dbSNP
rs757979836 888 dbSNP
rs866110170 888 dbSNP
rs1201938831 889 dbSNP
rs1157767173 907 dbSNP
rs1358553616 908 dbSNP
rs1273445406 950 dbSNP
rs1003858718 952 dbSNP
rs779908637 954 dbSNP
rs1345614445 957 dbSNP
rs368820361 962 dbSNP
rs1302527425 965 dbSNP
rs1234971134 966 dbSNP
rs1015100631 978 dbSNP
rs963984278 982 dbSNP
rs925069947 990 dbSNP
rs936788341 995 dbSNP
rs7879097 999 dbSNP
rs1384755234 1000 dbSNP
rs1394884614 1001 dbSNP
rs768608836 1002 dbSNP
rs1455975796 1022 dbSNP
rs1034938596 1035 dbSNP
rs75981565 1051 dbSNP
rs776594946 1058 dbSNP
rs1426650770 1059 dbSNP
rs1175045267 1068 dbSNP
rs958934312 1068 dbSNP
rs1469283680 1071 dbSNP
rs1233153450 1085 dbSNP
rs946197492 1122 dbSNP
rs1305216526 1130 dbSNP
rs190662039 1133 dbSNP
rs769778353 1142 dbSNP
rs917360789 1146 dbSNP
rs949388752 1169 dbSNP
rs1046428217 1171 dbSNP
rs905476867 1183 dbSNP
rs967356813 1202 dbSNP
rs977434012 1218 dbSNP
rs769931167 1230 dbSNP
rs935921208 1244 dbSNP
rs1039507885 1247 dbSNP
rs1313934535 1257 dbSNP
rs1437123228 1264 dbSNP
rs888587763 1319 dbSNP
rs1005980950 1320 dbSNP
rs1408119245 1346 dbSNP
rs1417952851 1346 dbSNP
rs1183814286 1355 dbSNP
rs1015113092 1358 dbSNP
rs921089282 1358 dbSNP
rs1188438714 1365 dbSNP
rs961769113 1376 dbSNP
rs1258841100 1378 dbSNP
rs933879802 1385 dbSNP
rs182900448 1394 dbSNP
rs1242820823 1399 dbSNP
rs1270102302 1408 dbSNP
rs1488216478 1414 dbSNP
rs1029921437 1416 dbSNP
rs953300344 1429 dbSNP
rs749315156 1430 dbSNP
rs1003809651 1437 dbSNP
rs1288757616 1445 dbSNP
rs1177848381 1448 dbSNP
rs1454767273 1450 dbSNP
rs1191064445 1463 dbSNP
rs925154773 1469 dbSNP
rs1160821626 1474 dbSNP
rs763153530 1494 dbSNP
rs1416778957 1495 dbSNP
rs936531148 1497 dbSNP
rs1425292245 1518 dbSNP
rs1259399511 1531 dbSNP
rs1185796595 1532 dbSNP
rs1402423744 1537 dbSNP
rs1249980188 1551 dbSNP
rs1159701540 1575 dbSNP
rs1349186486 1577 dbSNP
rs1455951538 1581 dbSNP
rs899380731 1583 dbSNP
rs73250631 1585 dbSNP
rs766568384 1585 dbSNP
rs914012255 1585 dbSNP
rs760881879 1600 dbSNP
rs1295327728 1618 dbSNP
rs1371370159 1624 dbSNP
rs1034644829 1626 dbSNP
rs1321943006 1631 dbSNP
rs1438017930 1637 dbSNP
rs1309055773 1651 dbSNP
rs143596333 1652 dbSNP
rs1459130207 1652 dbSNP
rs1225792261 1658 dbSNP
rs1014458597 1671 dbSNP
rs1169560802 1679 dbSNP
rs761231066 1679 dbSNP
rs1429020214 1701 dbSNP
rs1046440782 1702 dbSNP
rs1468061929 1729 dbSNP
rs1253709580 1732 dbSNP
rs770818986 1738 dbSNP
rs767821484 1740 dbSNP
rs977381758 1744 dbSNP
rs1469119196 1745 dbSNP
rs5967201 1745 dbSNP
rs1198223764 1746 dbSNP
rs925956833 1753 dbSNP
rs1301827738 1757 dbSNP
rs1471055706 1759 dbSNP
rs938261009 1761 dbSNP
rs1049091896 1767 dbSNP
rs1412991319 1781 dbSNP
rs1421910799 1782 dbSNP
rs957429881 1787 dbSNP
rs1323708580 1788 dbSNP
rs1388144340 1803 dbSNP
rs1166549161 1814 dbSNP
rs888689816 1818 dbSNP
rs1004828870 1820 dbSNP
rs975734034 1824 dbSNP
rs1464817863 1843 dbSNP
rs1171613717 1859 dbSNP
rs1453742775 1862 dbSNP
rs921215643 1869 dbSNP
rs933813822 1870 dbSNP
rs1417529642 1871 dbSNP
rs113280965 1874 dbSNP
rs753119361 1885 dbSNP
rs1484200926 1894 dbSNP
rs1248991749 1910 dbSNP
rs908260135 1915 dbSNP
rs939781236 1924 dbSNP
rs985802757 1935 dbSNP
rs1444834441 1952 dbSNP
rs187121793 1956 dbSNP
rs1038156296 1957 dbSNP
rs1280436205 1967 dbSNP
rs898150114 1978 dbSNP
rs1333502874 1983 dbSNP
rs1305802576 1985 dbSNP
rs1410060439 1994 dbSNP
rs1231985409 2004 dbSNP
rs1352042329 2028 dbSNP
rs1032695800 2034 dbSNP
rs1295253529 2045 dbSNP
rs1434025475 2045 dbSNP
rs1001898965 2075 dbSNP
rs764727889 2078 dbSNP
rs894739409 2080 dbSNP
rs1014409518 2082 dbSNP
rs759428020 2090 dbSNP
rs1183089933 2099 dbSNP
rs967421758 2110 dbSNP
rs998932668 2114 dbSNP
rs1187725377 2117 dbSNP
rs1204956940 2126 dbSNP
rs1486271261 2145 dbSNP
rs1033140061 2149 dbSNP
rs1203929270 2171 dbSNP
rs1236670379 2174 dbSNP
rs868636668 2176 dbSNP
rs957584838 2185 dbSNP
rs1228612410 2195 dbSNP
rs975470283 2196 dbSNP
rs1028631682 2198 dbSNP
rs1413885257 2199 dbSNP
rs955292769 2202 dbSNP
rs1418439358 2211 dbSNP
rs986560873 2216 dbSNP
rs1336015190 2217 dbSNP
rs908373509 2221 dbSNP
rs1384330225 2225 dbSNP
rs749885951 2227 dbSNP
rs1160083383 2232 dbSNP
rs1458988200 2241 dbSNP
rs112627370 2246 dbSNP
rs1164511995 2256 dbSNP
rs1473308177 2259 dbSNP
rs775289253 2268 dbSNP
rs1191593786 2273 dbSNP
rs1446995724 2276 dbSNP
rs1410178898 2277 dbSNP
rs1246882733 2284 dbSNP
rs1208857158 2289 dbSNP
rs1330750047 2292 dbSNP
rs919716104 2299 dbSNP
rs1232303655 2300 dbSNP
rs1356710825 2309 dbSNP
rs937644055 2311 dbSNP
rs765401301 2328 dbSNP
rs1054816583 2329 dbSNP
rs1413512997 2336 dbSNP
rs1321273836 2340 dbSNP
rs1325825273 2340 dbSNP
rs1437303374 2347 dbSNP
rs1315394440 2351 dbSNP
rs1392416247 2367 dbSNP
rs1325395328 2369 dbSNP
rs779818627 2380 dbSNP
rs894692680 2386 dbSNP
rs751211682 2389 dbSNP
rs141629759 2408 dbSNP
rs903348693 2412 dbSNP
rs1268418759 2422 dbSNP
rs1341810480 2425 dbSNP
rs999059643 2432 dbSNP
rs1166589795 2436 dbSNP
rs1475357729 2437 dbSNP
rs1033500778 2445 dbSNP
rs1391381805 2452 dbSNP
rs1191086022 2453 dbSNP
rs1465804580 2461 dbSNP
rs1250609242 2473 dbSNP
rs1220353498 2497 dbSNP
rs893235891 2523 dbSNP
rs997210017 2527 dbSNP
rs1212637069 2531 dbSNP
rs7062004 2547 dbSNP
rs901326554 2561 dbSNP
rs111821384 2587 dbSNP
rs955406730 2596 dbSNP
rs748045325 2607 dbSNP
rs1437456866 2614 dbSNP
rs1051489957 2630 dbSNP
rs1487884672 2635 dbSNP
rs763721458 2651 dbSNP
rs961182623 2653 dbSNP
rs973945663 2663 dbSNP
rs1392714432 2670 dbSNP
rs1475565243 2673 dbSNP
rs1190168600 2674 dbSNP
rs1478138563 2687 dbSNP
rs1007676543 2694 dbSNP
rs111425079 2703 dbSNP
rs1392833602 2706 dbSNP
rs1275108245 2712 dbSNP
rs1433270655 2722 dbSNP
rs1175853534 2727 dbSNP
rs1345728219 2740 dbSNP
rs777816815 2743 dbSNP
rs1219941738 2756 dbSNP
rs1376595333 2761 dbSNP
rs1369852316 2778 dbSNP
rs1277930679 2781 dbSNP
rs1441764910 2787 dbSNP
rs990858933 2794 dbSNP
rs1351468876 2824 dbSNP
rs373189427 2829 dbSNP
rs1433366289 2830 dbSNP
rs949072538 2835 dbSNP
rs758988598 2840 dbSNP
rs1375425078 2856 dbSNP
rs903467716 2858 dbSNP
rs1316383241 2874 dbSNP
rs1414502703 2883 dbSNP
rs183028366 2903 dbSNP
rs1431524514 2906 dbSNP
rs1472093765 2910 dbSNP
rs1252271055 2936 dbSNP
rs1184132489 2943 dbSNP
rs1484639727 2947 dbSNP
rs958203077 2948 dbSNP
rs1009446742 2949 dbSNP
rs1313962070 2951 dbSNP
rs1054650278 2974 dbSNP
rs1228007685 2975 dbSNP
rs138737369 2976 dbSNP
rs187652717 2978 dbSNP
rs1413269283 2984 dbSNP
rs996931259 2986 dbSNP
rs1378938188 2992 dbSNP
rs1236229045 2995 dbSNP
rs1303869028 3020 dbSNP
rs755338291 3024 dbSNP
rs1360378295 3043 dbSNP
rs1156399166 3061 dbSNP
rs781332722 3068 dbSNP
rs1352973382 3073 dbSNP
rs1203288946 3075 dbSNP
rs926716334 3085 dbSNP
rs1285792769 3086 dbSNP
rs1182359611 3100 dbSNP
rs891105243 3110 dbSNP
rs1008211588 3113 dbSNP
rs1484230951 3115 dbSNP
rs1447108606 3126 dbSNP
rs1208240424 3130 dbSNP
rs959478255 3132 dbSNP
rs1270202623 3153 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uaguuccaggcGACACUUGUGc 5'
                     || ||||||| 
Target 5' cuugaaauaaaCUUUGAACACa 3'
 		14 - 35
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000415585.2 | 3UTR | AUAUUUUCUGUGACUUGAAAUAAACUUUGAACACAAUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.62 1.2e-2 0.577 1.9e-2 13 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.315 8.8e-2 0.391 4.4e-2 20 Click to see details
GSE32688 Pancreatic cancer -0.235 9.8e-2 -0.174 1.7e-1 32 Click to see details
GSE38226 Liver fibrosis -0.285 1.1e-1 -0.358 5.6e-2 21 Click to see details
GSE21687 Ependynoma primary tumors -0.131 1.5e-1 0.113 1.9e-1 64 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.211 1.6e-1 -0.072 3.7e-1 25 Click to see details
GSE28544 Breast cancer 0.196 1.8e-1 0.249 1.2e-1 24 Click to see details
GSE17498 Multiple myeloma -0.146 1.8e-1 -0.178 1.4e-1 40 Click to see details
GSE42095 Differentiated embryonic stem cells 0.181 2.0e-1 0.034 4.4e-1 23 Click to see details
GSE26953 Aortic valvular endothelial cells 0.106 3.1e-1 0.021 4.6e-1 24 Click to see details
GSE19350 CNS germ cell tumors -0.049 4.4e-1 0.098 3.8e-1 12 Click to see details
GSE19350 CNS germ cell tumors -0.049 4.4e-1 0.098 3.8e-1 12 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
-0.049 4.4e-1 0.098 3.8e-1 12 Click to see details
-0.049 4.4e-1 0.098 3.8e-1 12 Click to see details
-0.049 4.4e-1 0.098 3.8e-1 12 Click to see details
65 hsa-miR-124-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT064177 KIAA1804 mitogen-activated protein kinase kinase kinase 21 2 2
MIRT069736 FOXG1 forkhead box G1 2 4
MIRT086429 NABP1 nucleic acid binding protein 1 2 6
MIRT105334 SLC7A2 solute carrier family 7 member 2 2 4
MIRT110455 PLEKHA1 pleckstrin homology domain containing A1 2 2
MIRT172998 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 2
MIRT196428 TAOK1 TAO kinase 1 2 14
MIRT325704 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT365670 TSC22D3 TSC22 domain family member 3 2 4
MIRT365873 XIAP X-linked inhibitor of apoptosis 2 2
MIRT404126 ASB1 ankyrin repeat and SOCS box containing 1 2 2
MIRT404626 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT405284 ARF1 ADP ribosylation factor 1 2 2
MIRT406099 PAGR1 PAXIP1 associated glutamate rich protein 1 2 2
MIRT446627 SDC3 syndecan 3 2 2
MIRT446906 RGS5 regulator of G protein signaling 5 2 2
MIRT461790 FXR2 FMR1 autosomal homolog 2 2 2
MIRT463982 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT464204 VGLL4 vestigial like family member 4 2 2
MIRT472790 MTMR4 myotubularin related protein 4 2 4
MIRT473485 MCFD2 multiple coagulation factor deficiency 2 2 2
MIRT481124 AZIN1 antizyme inhibitor 1 2 4
MIRT485060 SUCO SUN domain containing ossification factor 2 2
MIRT487343 HLA-DRA major histocompatibility complex, class II, DR alpha 2 2
MIRT491948 VPS52 VPS52, GARP complex subunit 2 2
MIRT497208 CDH7 cadherin 7 2 2
MIRT497476 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT528203 NELFE negative elongation factor complex member E 2 2
MIRT529255 TRIM4 tripartite motif containing 4 2 4
MIRT530096 PSAPL1 prosaposin like 1 (gene/pseudogene) 2 2
MIRT530597 C7orf33 chromosome 7 open reading frame 33 2 4
MIRT534980 PSAT1 phosphoserine aminotransferase 1 2 4
MIRT538326 CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 2 2
MIRT561237 ZNF652 zinc finger protein 652 2 2
MIRT562035 KRAS KRAS proto-oncogene, GTPase 2 2
MIRT563120 THAP5 THAP domain containing 5 2 2
MIRT563538 RBM41 RNA binding motif protein 41 2 2
MIRT566037 REV3L REV3 like, DNA directed polymerase zeta catalytic subunit 2 2
MIRT566505 PAWR pro-apoptotic WT1 regulator 2 2
MIRT566745 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT566850 LRRC58 leucine rich repeat containing 58 2 2
MIRT568077 CELF2 CUGBP Elav-like family member 2 2 2
MIRT576826 Tgfbr3 transforming growth factor, beta receptor III 2 2
MIRT608870 NR2E1 nuclear receptor subfamily 2 group E member 1 2 4
MIRT611997 VAC14 Vac14, PIKFYVE complex component 2 2
MIRT614054 FAM89A family with sequence similarity 89 member A 2 2
MIRT618800 SPATA21 spermatogenesis associated 21 2 2
MIRT619389 RSPH3 radial spoke head 3 homolog 2 2
MIRT622282 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT624026 EN2 engrailed homeobox 2 2 2
MIRT626000 MPEG1 macrophage expressed 1 2 2
MIRT641792 USP32 ubiquitin specific peptidase 32 2 2
MIRT651599 WDFY2 WD repeat and FYVE domain containing 2 2 2
MIRT659662 CDC73 cell division cycle 73 2 2
MIRT663010 KIAA1586 KIAA1586 2 2
MIRT663561 ASTN2 astrotactin 2 2 2
MIRT669312 C16orf72 chromosome 16 open reading frame 72 2 2
MIRT685216 POTED POTE ankyrin domain family member D 2 2
MIRT695757 ZNF117 zinc finger protein 117 2 2
MIRT697909 TXNRD1 thioredoxin reductase 1 2 2
MIRT707181 RPH3A rabphilin 3A 2 2
MIRT707214 TRIM13 tripartite motif containing 13 2 2
MIRT707478 SLCO4C1 solute carrier organic anion transporter family member 4C1 2 2
MIRT719507 LMAN2L lectin, mannose binding 2 like 2 2
MIRT755814 PARP1 poly(ADP-ribose) polymerase 1 2 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-124 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR) NULL 16078949 Microarray hepatocytes 23107762 2013 up-regulated
miR-124 Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse brain 19270793 2009 up-regulated
miR-124 Vorinostat (SAHA) approved 5311 Microarray A549 human non-small cell lung cancer cells 19513533 2009 up-regulated
miR-124 Cocaine NULL 446220 Quantitative real-time PCR HEK293 cells or rat brain parts 19703567 2009 down-regulated
miR-124 Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
miR-124 Chaihu Shugan San NULL NULL Microarray hippocampus 23947143 2013 up-regualted
miR-124 Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
miR-124 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) NULL 15625 Microarray embryos 22921993 2012 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-124-5p Paclitaxel 36314 NSC125973 approved resistant High Laryngeal Cancer cell line (Hep2)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive High Gastric Cancer cell line (MGC803)
hsa-miR-124-5p Methotrexate 126941 NSC740 approved resistant cell line (HT29)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (RPMI2650)
hsa-miR-124-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardB)
hsa-miR-124-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (PC3PR20)
hsa-miR-124-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-124-5p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-124-5p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-miR-124-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

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