miRTarBase - #MIRT331632


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pre-miRNA Information
pre-miRNA hsa-mir-4477a   
Genomic Coordinates chr9: 41233755 - 41233835
Description Homo sapiens miR-4477a stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4477a
Sequence 48| CUAUUAAGGACAUUUGUGAUUC |69
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1281813060 1 dbSNP
rs1352899679 1 dbSNP
rs1283566158 2 dbSNP
rs1236244724 4 dbSNP
rs75019967 4 dbSNP
rs1348124293 5 dbSNP
rs34026740 8 dbSNP
rs1288237115 9 dbSNP
rs71262206 10 dbSNP
rs1355759977 11 dbSNP
rs1300249508 16 dbSNP
rs1328879592 18 dbSNP
rs139133717 20 dbSNP
Putative Targets

Gene Information
Gene Symbol AASDHPPT   
Synonyms AASD-PPT, ACPS, CGI-80, LYS2, LYS5
Description aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase
Transcript NM_015423   
Expression
Putative miRNA Targets on AASDHPPT
3'UTR of AASDHPPT
(miRNA target sites are highlighted)		 
>AASDHPPT|NM_015423|3'UTR
   1 TGATTCCCTGAGTAACAAAGGGAAATGAAAACTGTTTGTGATCTTCCGTATTCACTGAAAAATAAATGCTTGTTTAGTAT
  81 CAAATTTTATTTCACGAAAGTTTTTTTAAAGAACAGAAACTTTTCCAATTAAAAAAAAAAAGCAGACTTCTGGTTCAAGA
 161 TAGCTCACTGGAATACATGTTTACCTCTTTCTTTCCTAAATTGCATTGAATTGATAGGAAGGATGGCGGAATCTTAAAGT
 241 GATACATGCTAACTGTAGAAAAAAATAGAAAATGCACATAAGCAAAAGGAAACATTTAAATGCTATCTTTCAAAGATAAC
 321 TACTCTTAAAACCTTGAGTATCTTTTCAGACCTTTTTCTTGGCAAATGAATCCATATTGACATATTTGATTTTTTTAAAA
 401 ACATGGAAACGTACTGTTTTGTAAATTCTTTTTAACTGCACATCTACTGTTCATAAATATACCTCTGTAACATAACTTTT
 481 TGTGGTTCTAATGTACTCTGTTGTATAGCTAATACAAGTTAGGATGCTTTTGGCCAGAGGTAACAGTGTCCAAATATAAT
 561 TGGCCTAAGTAACCTAGGAAATTGTTTGACATAACACAGGGTTCAGGGGTGTCATTAAAGACACACTTTTTTTGCCTTGA
 641 CCTCAGTTGGTTTGTTTTGCCTTAGGCTATTCCACCTCTCGATCACAAGAGCTGCTGCTATAACTTCCAGTTTTACATCT
 721 TTGTAAAATTGTATCTCAAAGGCAGAAAAGGCCATTTCGTCTCTCATTTGTTTTATCCATGAGGAAGATTTTTAACAAAA
 801 GCCTCCAGAAGATTTCCCCTCAGTTTCCATTGACTTAGATCAGGTTACAGAGAAAGGCAATGTCTGACATTTTTGGTCTC
 881 TGTTAGAAGTAGACTCTGTTGAAAAGAAAGAAGCTAAGCTAGGTGTGAAGAATGGAATTGGAAGCCCACTGCCTTCCCAT
 961 AAGAAAGGTTTACCATAATTTACTCACTTTTTTCTGTGTTAGACATTTTGATTATCTGCAGTTTATTACTACAAGCAGTG
1041 GCAGAGTGAATGTCCTTGTACATTTTGAGTTACATGCTTAATTATGTCCTTGAGAAAGTTTCTAAAAGTGGAATGATTGG
1121 TTTGACTGGTTCATAGGGCTTTAATTATACAATTTACCCCTCTAATTAGTACTATATGTATGTGACTTCCCTCCCCCTGC
1201 CAGAATACTCCTTGGTCAATTGTAGGTATTCTTTTTGGTTTAATTTTTGCCAATGTAATTAAAAAATGGTATGTCATTTT
1281 TAAAATTTGTATTTCTTTCATTACAAATAAGATTGTTATGTCAGTATTGTTATTGGCTTTTCGTATTCCTCTTAACGTGA
1361 ACCGTCTGTTCATTGTTTTTACCTGTTTTCGTTTTAGCAAGTAGTACTTAATTTAAAGTGTGAACTTAATATATAAGATG
1441 CCAGGACCATCATATTGATGACAAAAATCTATTATGTGGTTGTAGTGCATGTCTTGGAGTTAAACTCTTAAGTATCAAGA
1521 AGTAAAATAATTTCATTGTTTCTGTTACTAACATTAAAAGTGTGCAAATTGTATAAAATTAGGTACTTCGATTAGTAAAA
1601 GAAAAAAATTTGAATGTTTTTTTTTTTTATTTTATTAAGCATGCCCAGTTATGCCAAGCATAGTAAATAAAGGTCAAGTA
1681 GCATTTATAATAGAGGAAGTATTGTTATCCCTAGCATGAGTGTAATGGTGATATGAAAAACTTTGTCTTGTCATTATAAT
1761 AATAAAAAAATGAACATTTATTATGAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuUAGUGUUUACA--GGAAUUAUc 5'
            ||:  ||:|||   ||||||| 
Target 5' taATTTAAAGTGTGAACTTAATAt 3'
 1409 - 1432 158.00 -7.30
2 
miRNA  3' cuUAGUGUUUACAGGAAUUAuc 5'
            :|:||  |||  ||||||  
Target 5' gaGTTAC--ATG--CTTAATta 3'
 1067 - 1084 132.00 -8.20
3 
miRNA  3' cuuagUGUUUAC--AGGAAUUAUc 5'
               |:|||||  | :|||:|| 
Target 5' gaaaaATAAATGCTTGTTTAGTAt 3'
 57 - 80 131.00 -7.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30473754 54 COSMIC
COSN13298053 97 COSMIC
COSN30121939 100 COSMIC
COSN27309083 142 COSMIC
COSN30061369 159 COSMIC
COSN5295728 389 COSMIC
COSN20627237 568 COSMIC
COSN31778896 703 COSMIC
COSN8212860 741 COSMIC
COSN5256280 809 COSMIC
COSN16245767 1404 COSMIC
COSN22501508 1443 COSMIC
COSN9029946 1490 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs772876329 1 dbSNP
rs766169452 10 dbSNP
rs368570555 11 dbSNP
rs754898031 12 dbSNP
rs1281479912 13 dbSNP
rs200693517 14 dbSNP
rs1430682833 15 dbSNP
rs1178844058 17 dbSNP
rs186476157 21 dbSNP
rs756129079 24 dbSNP
rs543573488 25 dbSNP
rs749483980 26 dbSNP
rs753886943 33 dbSNP
rs370423833 35 dbSNP
rs923258302 40 dbSNP
rs779310937 41 dbSNP
rs757295165 42 dbSNP
rs746432274 43 dbSNP
rs369569371 44 dbSNP
rs776069965 48 dbSNP
rs374891598 49 dbSNP
rs1326171940 51 dbSNP
rs1482553761 52 dbSNP
rs1272030874 55 dbSNP
rs1406736644 67 dbSNP
rs909811744 80 dbSNP
rs888048132 89 dbSNP
rs961212666 94 dbSNP
rs573652164 96 dbSNP
rs1036517251 97 dbSNP
rs1410490416 98 dbSNP
rs773915396 99 dbSNP
rs919342156 100 dbSNP
rs898017293 101 dbSNP
rs1403367802 103 dbSNP
rs938806217 109 dbSNP
rs1013748381 111 dbSNP
rs1057148585 115 dbSNP
rs544243871 116 dbSNP
rs1182348187 119 dbSNP
rs1471977778 126 dbSNP
rs1248903974 127 dbSNP
rs1940755 128 dbSNP
rs915879990 129 dbSNP
rs1485767324 131 dbSNP
rs368580660 131 dbSNP
rs948737043 131 dbSNP
rs562724196 132 dbSNP
rs904818696 142 dbSNP
rs533250072 165 dbSNP
rs72977072 168 dbSNP
rs999017419 172 dbSNP
rs957938545 180 dbSNP
rs1224973813 186 dbSNP
rs113901481 197 dbSNP
rs900916904 198 dbSNP
rs1160563492 206 dbSNP
rs1387861008 206 dbSNP
rs1211398136 210 dbSNP
rs1490278484 214 dbSNP
rs1472946409 217 dbSNP
rs181132335 228 dbSNP
rs866061106 229 dbSNP
rs1448512072 233 dbSNP
rs1248335033 241 dbSNP
rs185327669 243 dbSNP
rs773121274 244 dbSNP
rs1193180433 247 dbSNP
rs1235179292 248 dbSNP
rs567435411 256 dbSNP
rs923381072 267 dbSNP
rs1283815771 274 dbSNP
rs1445982321 279 dbSNP
rs931950553 283 dbSNP
rs147946690 284 dbSNP
rs1364597531 293 dbSNP
rs1016842745 295 dbSNP
rs1290415225 296 dbSNP
rs1435057161 301 dbSNP
rs909240748 306 dbSNP
rs189738400 315 dbSNP
rs1036654591 316 dbSNP
rs1293404944 326 dbSNP
rs533679053 327 dbSNP
rs1161095424 328 dbSNP
rs1248307275 342 dbSNP
rs551363423 352 dbSNP
rs1187652424 358 dbSNP
rs1463519469 358 dbSNP
rs1046548540 369 dbSNP
rs1254789041 370 dbSNP
rs183456565 371 dbSNP
rs1452261230 375 dbSNP
rs1274711131 377 dbSNP
rs960579794 382 dbSNP
rs1359017357 390 dbSNP
rs1228100880 397 dbSNP
rs539310369 397 dbSNP
rs1363721966 398 dbSNP
rs1031951797 404 dbSNP
rs1437721314 405 dbSNP
rs916015693 411 dbSNP
rs775187307 412 dbSNP
rs1370755014 414 dbSNP
rs554205961 417 dbSNP
rs1009433022 429 dbSNP
rs868621769 437 dbSNP
rs978763446 440 dbSNP
rs576712227 441 dbSNP
rs1396592509 442 dbSNP
rs1462229332 444 dbSNP
rs1477629419 445 dbSNP
rs1246235661 447 dbSNP
rs1219428093 448 dbSNP
rs1020836417 449 dbSNP
rs1183682655 457 dbSNP
rs1484189477 472 dbSNP
rs141764480 473 dbSNP
rs545706895 477 dbSNP
rs1053374571 489 dbSNP
rs762473708 490 dbSNP
rs1160907962 492 dbSNP
rs901301559 506 dbSNP
rs1367469111 507 dbSNP
rs976629826 514 dbSNP
rs1452836929 515 dbSNP
rs1287002891 519 dbSNP
rs145522053 522 dbSNP
rs1307033266 530 dbSNP
rs1377069460 534 dbSNP
rs1176471020 536 dbSNP
rs147804891 542 dbSNP
rs953472807 552 dbSNP
rs986238064 553 dbSNP
rs909209454 558 dbSNP
rs1473613032 560 dbSNP
rs1252543271 561 dbSNP
rs963405872 562 dbSNP
rs1181742810 563 dbSNP
rs1482167092 566 dbSNP
rs11226919 578 dbSNP
rs796295245 590 dbSNP
rs1258164134 591 dbSNP
rs1337480425 591 dbSNP
rs1211223888 592 dbSNP
rs1312170811 594 dbSNP
rs1277103092 595 dbSNP
rs1382214959 597 dbSNP
rs1450708654 609 dbSNP
rs889563504 621 dbSNP
rs1317865783 626 dbSNP
rs1238821542 627 dbSNP
rs1259427856 628 dbSNP
rs1407647048 629 dbSNP
rs1380849200 631 dbSNP
rs1303265854 637 dbSNP
rs1326285794 641 dbSNP
rs972271643 642 dbSNP
rs1357427837 645 dbSNP
rs1005208729 646 dbSNP
rs73537649 654 dbSNP
rs1457646384 660 dbSNP
rs148845850 661 dbSNP
rs1046546156 666 dbSNP
rs1258503429 670 dbSNP
rs1034959289 677 dbSNP
rs926810354 681 dbSNP
rs937762117 682 dbSNP
rs1053503843 687 dbSNP
rs1266985617 691 dbSNP
rs1156689731 696 dbSNP
rs1226020711 701 dbSNP
rs1022994275 702 dbSNP
rs751295883 703 dbSNP
rs1312985273 705 dbSNP
rs970148102 707 dbSNP
rs1231049250 708 dbSNP
rs552720387 720 dbSNP
rs1470252775 739 dbSNP
rs1175694442 740 dbSNP
rs978727558 741 dbSNP
rs1445964295 745 dbSNP
rs1320029889 751 dbSNP
rs761653022 756 dbSNP
rs577598024 759 dbSNP
rs1165754144 760 dbSNP
rs1391113787 764 dbSNP
rs545266531 780 dbSNP
rs1423415916 782 dbSNP
rs1190873359 789 dbSNP
rs1412119925 789 dbSNP
rs901101428 791 dbSNP
rs998537236 795 dbSNP
rs1206358529 796 dbSNP
rs1489179909 807 dbSNP
rs1265453778 818 dbSNP
rs989438890 823 dbSNP
rs1028138991 824 dbSNP
rs922896157 824 dbSNP
rs954053376 829 dbSNP
rs1286841210 834 dbSNP
rs1228839380 841 dbSNP
rs1364444959 842 dbSNP
rs1295305027 849 dbSNP
rs934128973 855 dbSNP
rs1392998440 858 dbSNP
rs1294150312 863 dbSNP
rs143466600 870 dbSNP
rs779905903 885 dbSNP
rs1170941291 889 dbSNP
rs1049949727 891 dbSNP
rs527446093 892 dbSNP
rs1389869539 894 dbSNP
rs889537501 894 dbSNP
rs1267475473 897 dbSNP
rs190756578 897 dbSNP
rs1007639985 903 dbSNP
rs1016364340 910 dbSNP
rs1190086838 920 dbSNP
rs548774582 923 dbSNP
rs1276317909 924 dbSNP
rs1038133164 931 dbSNP
rs972073533 936 dbSNP
rs1251474658 938 dbSNP
rs993868756 946 dbSNP
rs919281033 949 dbSNP
rs1175190990 951 dbSNP
rs1270762995 952 dbSNP
rs1331579951 958 dbSNP
rs750365556 968 dbSNP
rs1302129582 985 dbSNP
rs982813198 986 dbSNP
rs1035332279 988 dbSNP
rs1480670063 988 dbSNP
rs1198563281 991 dbSNP
rs1427153956 995 dbSNP
rs1412785723 1001 dbSNP
rs1430583893 1005 dbSNP
rs896438768 1012 dbSNP
rs1166474270 1015 dbSNP
rs566498170 1020 dbSNP
rs1012029887 1027 dbSNP
rs561001456 1030 dbSNP
rs938191013 1032 dbSNP
rs527363004 1034 dbSNP
rs1197614841 1040 dbSNP
rs1023462254 1062 dbSNP
rs549903043 1068 dbSNP
rs758462785 1073 dbSNP
rs1253260094 1075 dbSNP
rs183675852 1084 dbSNP
rs1000652680 1087 dbSNP
rs1042040851 1089 dbSNP
rs1249400564 1091 dbSNP
rs1306456724 1093 dbSNP
rs756193564 1100 dbSNP
rs1345706614 1114 dbSNP
rs998110957 1116 dbSNP
rs1230895020 1117 dbSNP
rs1321528405 1124 dbSNP
rs1290241117 1125 dbSNP
rs988851067 1129 dbSNP
rs1366136832 1133 dbSNP
rs922831685 1134 dbSNP
rs372530226 1138 dbSNP
rs1295670891 1144 dbSNP
rs955641700 1145 dbSNP
rs571600195 1158 dbSNP
rs889589614 1162 dbSNP
rs1413557604 1166 dbSNP
rs911359640 1175 dbSNP
rs941523891 1179 dbSNP
rs188134950 1181 dbSNP
rs1293545856 1185 dbSNP
rs1189442128 1193 dbSNP
rs918368475 1195 dbSNP
rs1016329373 1209 dbSNP
rs1255153052 1211 dbSNP
rs1198687406 1212 dbSNP
rs899236239 1216 dbSNP
rs994013063 1218 dbSNP
rs1266603115 1225 dbSNP
rs192927390 1226 dbSNP
rs566261083 1230 dbSNP
rs1187093875 1231 dbSNP
rs1247178175 1235 dbSNP
rs777752617 1242 dbSNP
rs184552615 1251 dbSNP
rs1333864296 1252 dbSNP
rs73537650 1254 dbSNP
rs982353209 1257 dbSNP
rs1320711726 1259 dbSNP
rs1405084450 1268 dbSNP
rs1456244937 1268 dbSNP
rs556033259 1269 dbSNP
rs1000722954 1276 dbSNP
rs1367714840 1277 dbSNP
rs1181489210 1283 dbSNP
rs1451304157 1285 dbSNP
rs1033492685 1288 dbSNP
rs1209511121 1290 dbSNP
rs537921147 1296 dbSNP
rs959506408 1299 dbSNP
rs956177440 1305 dbSNP
rs1282168396 1307 dbSNP
rs1211881018 1315 dbSNP
rs989618861 1316 dbSNP
rs1357268173 1318 dbSNP
rs1284024695 1319 dbSNP
rs80195741 1321 dbSNP
rs1029630096 1322 dbSNP
rs1302932314 1326 dbSNP
rs1342950817 1333 dbSNP
rs1348575573 1334 dbSNP
rs867893861 1343 dbSNP
rs577537432 1344 dbSNP
rs1360623642 1347 dbSNP
rs1225589758 1357 dbSNP
rs73537654 1358 dbSNP
rs978283667 1361 dbSNP
rs922284057 1364 dbSNP
rs933658327 1365 dbSNP
rs796381605 1391 dbSNP
rs757621650 1392 dbSNP
rs1452466943 1395 dbSNP
rs1291315698 1396 dbSNP
rs1216370191 1403 dbSNP
rs1241475561 1408 dbSNP
rs889722215 1411 dbSNP
rs1344778367 1422 dbSNP
rs941288432 1426 dbSNP
rs541472313 1431 dbSNP
rs929783148 1432 dbSNP
rs1038192275 1434 dbSNP
rs917546685 1450 dbSNP
rs1436550692 1456 dbSNP
rs150930147 1459 dbSNP
rs1300905714 1465 dbSNP
rs7554 1468 dbSNP
rs1370960283 1479 dbSNP
rs1167684700 1483 dbSNP
rs1026826891 1489 dbSNP
rs1427166057 1513 dbSNP
rs1174459561 1525 dbSNP
rs1478400800 1534 dbSNP
rs1268200416 1536 dbSNP
rs1160420390 1539 dbSNP
rs906497709 1545 dbSNP
rs1197568057 1551 dbSNP
rs1044935754 1554 dbSNP
rs1345141199 1566 dbSNP
rs574923807 1567 dbSNP
rs140657313 1574 dbSNP
rs1306324459 1582 dbSNP
rs1281338972 1587 dbSNP
rs1003973516 1590 dbSNP
rs1280751895 1591 dbSNP
rs1411311644 1592 dbSNP
rs1307246228 1602 dbSNP
rs1350694039 1602 dbSNP
rs1439748836 1603 dbSNP
rs1360617689 1610 dbSNP
rs1033862854 1611 dbSNP
rs1413792524 1615 dbSNP
rs1428722911 1615 dbSNP
rs1174332459 1616 dbSNP
rs891872342 1616 dbSNP
rs1239516518 1617 dbSNP
rs1479864030 1617 dbSNP
rs370229857 1617 dbSNP
rs58915339 1617 dbSNP
rs878949853 1617 dbSNP
rs959600737 1623 dbSNP
rs989712198 1624 dbSNP
rs1048683 1625 dbSNP
rs1229673794 1625 dbSNP
rs966883492 1629 dbSNP
rs1224148349 1630 dbSNP
rs1221661556 1632 dbSNP
rs1283395633 1635 dbSNP
rs1326997790 1641 dbSNP
rs1381103342 1642 dbSNP
rs1029765899 1652 dbSNP
rs1245035763 1660 dbSNP
rs1451879636 1660 dbSNP
rs1334868934 1666 dbSNP
rs891109142 1672 dbSNP
rs1389378459 1673 dbSNP
rs1461870631 1686 dbSNP
rs1158670136 1688 dbSNP
rs1328617032 1691 dbSNP
rs118065945 1697 dbSNP
rs1182772410 1698 dbSNP
rs922345759 1701 dbSNP
rs933647465 1707 dbSNP
rs1241830752 1709 dbSNP
rs963028763 1711 dbSNP
rs1464969278 1713 dbSNP
rs144891342 1715 dbSNP
rs1178153437 1718 dbSNP
rs1407811279 1722 dbSNP
rs1323116302 1727 dbSNP
rs1313229200 1730 dbSNP
rs1025769631 1742 dbSNP
rs1456099648 1743 dbSNP
rs951637344 1745 dbSNP
rs1406133350 1751 dbSNP
rs1468860692 1753 dbSNP
rs910914297 1755 dbSNP
rs1331732484 1762 dbSNP
rs991840135 1764 dbSNP
rs138744064 1771 dbSNP
rs1451946577 1771 dbSNP
rs1351811983 1776 dbSNP
rs941256007 1777 dbSNP
rs917682489 1784 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545214. RNA binding protein: AGO3. Condition:Control ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_015423 | 3UTR | AAGUAGUACUUAAUUUAAAGUGUGAACUUAAUAUAUAAGAUGCCAGGACCAUCAUAUUGAUGACAAAAAUCUAUUAUGUGGUUGUAGUGCAUGUCUUGGAGUUAAACUCUUAAGUAUCAAGAAGUAAAAUAAUUUCAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_015423 | 3UTR | UGAACUUAAUAUAUAAGAUGCCAGGACCAUCAUAUUGAUGACAAAAAUCUAUUAUGUGGUUGUAGUGCAUGUCUUGGAGUUAAACUCUUAAGUAUCAAGAAGUAAAAUAAUUUCAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_015423 | 3UTR | GUACUUAAUUUAAAGUGUGAACUUAAUAUAUAAGAUGCCAGGACCAUCAUAUUGAUGACAAAAAUCUAUUAUGUGGUUGUAGUGCAUGUCUUGGAGUUAAACUCUUAAGUAUCAAGAAGUAAAAUAAUUUCAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_015423 | 3UTR | AUAUAUAAGAUGCCAGGACCAUCAUAUUGAUGACAAAAAUCUAUUAUGUGGUUGUAGUGCAUGUCUUGGAGUUAAACUCUUAAGUAUCAAGAAGUAAAAUAAUUUCAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_015423 | 3UTR | UGAACUUAAUAUAUAAGAUGCCAGGACCAUCAUAUUGAUGACAAAAAUCUAUUAUGUGGUUGUAGUGCAUGUCUUGGAGUUAAACUCUUAAGUAUCAAGAAGUAAAAUAAUUUCAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_015423 | 3UTR | AGUGUGAACUUAAUAUAUAAGAUGCCAGGACCAUCAUAUUGAUGACAAAAAUCUAUUAUGUGGUUGUAGUGCAUGUCUUGGAGUUAAACUCUUAAGUAUCAAGAAGUAAAAUAAUUUCAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM545214
Method / RBP PAR-CLIP / AGO3
Cell line / Condition HEK293 / Control
Location of target site ENST00000278618.4 | 3UTR | AACUUAAUAUAUAAGAUGCCAGGACCAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
134 hsa-miR-4477a Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055843 PLEKHA1 pleckstrin homology domain containing A1 2 10
MIRT061259 AMOTL1 angiomotin like 1 2 4
MIRT071895 BTF3L4 basic transcription factor 3 like 4 2 6
MIRT076933 MLLT6 MLLT6, PHD finger containing 2 2
MIRT078652 ICT1 mitochondrial ribosomal protein L58 2 2
MIRT083633 PRNP prion protein 2 2
MIRT091629 RPL15 ribosomal protein L15 2 4
MIRT107076 PPP6C protein phosphatase 6 catalytic subunit 2 2
MIRT111191 TRIM33 tripartite motif containing 33 2 2
MIRT114515 ARF6 ADP ribosylation factor 6 2 2
MIRT175250 PSAT1 phosphoserine aminotransferase 1 2 4
MIRT175430 ACSL4 acyl-CoA synthetase long chain family member 4 2 2
MIRT178687 FAM102B family with sequence similarity 102 member B 2 2
MIRT189771 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT229450 RPL10 ribosomal protein L10 2 2
MIRT244899 PHF6 PHD finger protein 6 2 2
MIRT249189 AKIRIN1 akirin 1 2 8
MIRT261134 TRIM8 tripartite motif containing 8 2 2
MIRT275561 ZIC5 Zic family member 5 2 4
MIRT275652 ABHD13 abhydrolase domain containing 13 2 2
MIRT288082 UTP18 UTP18, small subunit processome component 2 2
MIRT303605 MTHFD2 methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase 2 2
MIRT307924 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT316787 FOXC1 forkhead box C1 2 2
MIRT326910 SCML2 Scm polycomb group protein like 2 2 2
MIRT327713 SPIN4 spindlin family member 4 2 2
MIRT331632 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT342506 TMOD3 tropomodulin 3 2 4
MIRT354470 LRRC58 leucine rich repeat containing 58 2 2
MIRT378711 TRIM24 tripartite motif containing 24 2 2
MIRT407462 YDJC YdjC chitooligosaccharide deacetylase homolog 2 2
MIRT408226 SMAD5 SMAD family member 5 2 4
MIRT441824 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT442783 CHD8 chromodomain helicase DNA binding protein 8 2 2
MIRT443184 NHS NHS actin remodeling regulator 2 4
MIRT447615 CUL3 cullin 3 2 2
MIRT450156 DSEL dermatan sulfate epimerase-like 2 2
MIRT454801 NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2 2
MIRT463050 ZNF644 zinc finger protein 644 2 2
MIRT467400 SOCS3 suppressor of cytokine signaling 3 2 2
MIRT468174 SGMS1 sphingomyelin synthase 1 2 2
MIRT468949 RPS14 ribosomal protein S14 2 6
MIRT469835 R3HDM4 R3H domain containing 4 2 2
MIRT470724 POFUT1 protein O-fucosyltransferase 1 2 2
MIRT470902 PLIN3 perilipin 3 2 2
MIRT472467 NAPG NSF attachment protein gamma 2 12
MIRT472602 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT492350 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT493840 FOXN3 forkhead box N3 2 4
MIRT496318 DOCK9 dedicator of cytokinesis 9 2 2
MIRT500159 CLEC2D C-type lectin domain family 2 member D 2 8
MIRT500535 XPO4 exportin 4 2 4
MIRT503916 FBXL13 F-box and leucine rich repeat protein 13 2 4
MIRT504003 SAT1 spermidine/spermine N1-acetyltransferase 1 2 4
MIRT505647 SHMT1 serine hydroxymethyltransferase 1 2 4
MIRT506574 MIER3 MIER family member 3 2 4
MIRT506945 HS3ST3B1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 2 4
MIRT508196 RPS19 ribosomal protein S19 2 6
MIRT511417 HSPA13 heat shock protein family A (Hsp70) member 13 2 4
MIRT512326 ACTB actin beta 2 4
MIRT515376 RPL7 ribosomal protein L7 2 2
MIRT520422 TUBG1 tubulin gamma 1 2 4
MIRT524844 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT526320 UGT2A1 UDP glucuronosyltransferase family 2 member A1 complex locus 2 2
MIRT526561 UGT2A2 UDP glucuronosyltransferase family 2 member A2 2 2
MIRT528027 FEZ2 fasciculation and elongation protein zeta 2 2 2
MIRT529874 RBM43 RNA binding motif protein 43 2 2
MIRT530826 CLEC4D C-type lectin domain family 4 member D 2 2
MIRT531334 GDPD1 glycerophosphodiester phosphodiesterase domain containing 1 2 2
MIRT532068 CCNB1 cyclin B1 2 4
MIRT532870 ZNF566 zinc finger protein 566 2 2
MIRT535580 NUP35 nucleoporin 35 2 2
MIRT537644 ERGIC2 ERGIC and golgi 2 2 4
MIRT537725 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT538894 BRI3BP BRI3 binding protein 2 2
MIRT538945 BMP2K BMP2 inducible kinase 2 2
MIRT540703 PDPK1 3-phosphoinositide dependent protein kinase 1 2 4
MIRT543210 TMEM117 transmembrane protein 117 2 3
MIRT543357 LYRM2 LYR motif containing 2 2 2
MIRT544905 CLSPN claspin 2 2
MIRT545532 ARF3 ADP ribosylation factor 3 2 2
MIRT546446 SMOC1 SPARC related modular calcium binding 1 2 2
MIRT546882 PURB purine rich element binding protein B 2 4
MIRT547440 MED13 mediator complex subunit 13 2 2
MIRT548027 GOLIM4 golgi integral membrane protein 4 2 2
MIRT548673 CRNKL1 crooked neck pre-mRNA splicing factor 1 2 2
MIRT550435 LLGL2 LLGL2, scribble cell polarity complex component 2 2
MIRT551850 RPS3 ribosomal protein S3 2 2
MIRT556072 MRFAP1 Morf4 family associated protein 1 2 2
MIRT556554 LIMS1 LIM zinc finger domain containing 1 2 2
MIRT557132 HOXA13 homeobox A13 2 2
MIRT557875 FEM1B fem-1 homolog B 2 4
MIRT558146 ELK4 ELK4, ETS transcription factor 2 2
MIRT558862 CD2AP CD2 associated protein 2 2
MIRT558884 CCNE1 cyclin E1 2 4
MIRT558907 CBX5 chromobox 5 2 2
MIRT559175 BRAP BRCA1 associated protein 2 2
MIRT560860 GAL3ST3 galactose-3-O-sulfotransferase 3 2 2
MIRT561729 PPIF peptidylprolyl isomerase F 2 2
MIRT564024 CEBPB CCAAT/enhancer binding protein beta 2 2
MIRT564366 TRMT5 tRNA methyltransferase 5 2 2
MIRT564609 ZNF703 zinc finger protein 703 2 2
MIRT565494 AZF1 azoospermia factor 1 2 2
MIRT565577 SLC6A8 solute carrier family 6 member 8 2 2
MIRT566947 LEPROT leptin receptor overlapping transcript 2 2
MIRT567293 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT567308 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT568048 CHSY1 chondroitin sulfate synthase 1 2 2
MIRT571807 PHF19 PHD finger protein 19 2 2
MIRT609234 RBM23 RNA binding motif protein 23 2 2
MIRT610328 SSX5 SSX family member 5 2 2
MIRT611428 UGT8 UDP glycosyltransferase 8 2 4
MIRT611709 SLFN13 schlafen family member 13 2 2
MIRT612069 CEP135 centrosomal protein 135 2 4
MIRT617676 JRKL JRK like 2 2
MIRT623684 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT635634 PRR15L proline rich 15 like 2 2
MIRT636422 MBOAT2 membrane bound O-acyltransferase domain containing 2 2 2
MIRT637011 GPATCH11 G-patch domain containing 11 2 2
MIRT644150 C4orf3 chromosome 4 open reading frame 3 2 2
MIRT648562 MEMO1 mediator of cell motility 1 2 2
MIRT650752 WNT16 Wnt family member 16 2 2
MIRT651914 UEVLD UEV and lactate/malate dehyrogenase domains 2 2
MIRT653556 SLC38A7 solute carrier family 38 member 7 2 2
MIRT692277 XRN2 5'-3' exoribonuclease 2 2 2
MIRT697650 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT703876 ERCC6 ERCC excision repair 6, chromatin remodeling factor 2 2
MIRT704615 CLIP1 CAP-Gly domain containing linker protein 1 2 2
MIRT708562 BBOX1 gamma-butyrobetaine hydroxylase 1 2 2
MIRT709614 KBTBD6 kelch repeat and BTB domain containing 6 2 2
MIRT712955 SGCD sarcoglycan delta 2 2
MIRT713502 DCAF17 DDB1 and CUL4 associated factor 17 2 2
MIRT720239 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT724255 GLUD1 glutamate dehydrogenase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-4477a Imatinib 5291 NSC743414 approved sensitive High Gastrointestinal Stromal Tumor cell line (882R-NC, 882R-OE, 882R-KD)
hsa-miR-4477a Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-4477a Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)

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