miRTarBase - #MIRT333632


—
pre-miRNA Information
pre-miRNA hsa-mir-5197   
Genomic Coordinates chr5: 143679860 - 143679971
Description Homo sapiens miR-5197 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-5197-3p
Sequence 64| AAGAAGAGACUGAGUCAUCGAAU |86
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs77549240 8 dbSNP
rs1411653302 10 dbSNP
rs1347866830 14 dbSNP
rs892818585 19 dbSNP
rs1405555825 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ZFP91   
Synonyms DMS-8, DSM-8, FKSG11, PZF, ZFP-91, ZNF757
Description ZFP91 zinc finger protein
Transcript NM_053023   
Expression
Putative miRNA Targets on ZFP91
3'UTR of ZFP91
(miRNA target sites are highlighted)		 
>ZFP91|NM_053023|3'UTR
   1 TGGACAGGAAGACTTGGGGCATGGGACAGCTCAGACTTTGTATTTAAAAGTTAAAAAGGACAAAAAAAAAATCTAAAGCA
  81 TTTAAAATCTAGTGAAATAACTGAAGGGCCTGCTCTTTCCATTGTGGATCACAGCACACACATACATACACCCTCCACCT
 161 CCCCATCCCCTGTTCTCCCTCTGTTGCTCCCCTTATAAAATTGATGTTGTCTTTACCAGAAAGGTAGACAAAAAAGAAGC
 241 AGCAGCAGCTCTTAAAGTGAGGGTTATTCTCATACTCGGTTCCAGCCATCAGCAGACTTCCTGCTCATCGGCAGATCCCC
 321 CTTTCCAACCTGTAACTCTGATGTGCTCTGGATCAGCTTTTAACTTTTAATCATATATTACTGTCTTCTAAATCCCTTCT
 401 CCTCCTCTACTGCTGCCCTATGGTTCTGGCTCCTACCCCCTGCGGCACACTTATCTTCAAATACCATAGAATTCTAATCT
 481 CTGGAGGCTGGCAGCTTGACTTGGCACTTTAGGGCCCCTTAGCAGGGTGAGCTGTTAAAACAGCACACATCTCTCATCCC
 561 CTCTTCCTTTATTCCCCCCTGGGTTTCAGAAAGGAAGGATATATGGGGACCACCTCCCCCTTCTTTGATCCCAGCATCTC
 641 AGTCCCCCTCCCAACCCTCCATATGGCTCTCAATGGTGCTCACTTGCTTGGAAGCAGGCTCCCAATAGGGAGGGGGCTGC
 721 CCTCTACAGTCTCTTTGACTGTAAGACAGGGCTCTGTATCAGTGAGACGATGAGAAAAGTCCCAGGCTAATGGCAGAAAT
 801 TTGCACTTTGAACATGTGTGTTTTTGTGTTGTGGAACCTGAGATTCCTTATTTATTAACAGGAAGTCTGATTTTTTTTTT
 881 TTGGAGTCTTTGTTGCTATATTTTGTGGGGCTGGGAGAGAGAGATTAGATTATTTTGACATGGGATCCCTTCCATAACAG
 961 GTACTTTGAAGGCAAGACATAGGGTTGAAGAAGCACAGCCAGCCTCTGAAATCATAGCTCTCCAGTGGCTTTTAAAGAAA
1041 GCTGGTCCTCAGCACTAACAAAATCACTACAATAGCCTAGTGCTTTTTTGGAAGCCTTTTTAGGGAAGAATGTTAGGTTC
1121 ATGGTAACTAGTATGCTCTTTGAGATTTTTACAGTGTTGAAACTTAAGAATTTTGAGAGGGTGAGGAGGGTTGTTCAGAA
1201 TCTAAATTACAGATAGATGATTGTTTCTTGTGAATTTGTTTCTTTTCCTTTTTTTTTGTCCCTACCATTTCCTTACATTT
1281 CCCTTGGGGCCCATCTCTGGCTCCTTGCTTTTTGTTTCTTGCTTTGCTTTATCAGTTCATTCCAGCTCCCTGTTAGTGAA
1361 GGACACTGCTGTTAGTGAAGGAACAAAGTCTATGAGTCCTAAAATTTTAAGTCAAAGAAAACTGCTCTGTTTCCCCTTTA
1441 GTAACACTTCTGAAGAGGAAAAACTTCAATAGCCAAAGTTAATAATCCTATATAATAATTGCTTTGGCTTTCACCTAAAA
1521 TTCTGGGCATCACAATTTCCTTGGGATAGAGGTTGTGTTGGGGAATAGATTGCTTATTGCTGTTCACTGGAGAGAAAAGG
1601 TAGTGTTTTTGTACAAGGTCATACCGCCAGAAGCCCCAAATCCTATTTTGGCTCATCTTCAGGTAAAGAGTAATTCCTAT
1681 CCTGTGTGCCTCAGAAGCTAGAATCGAAGGCTTACCCTATTCATTGTTTATTGTCAGAAATGCATGATGGCTCTTGGAAA
1761 GAATGACGTTTTGCTGGAAAAAAAAAAAAGAACAGTTTGTGTTTCACAAACATGGCTTATCAATTTTTTCAAAGAATTCT
1841 TTTTTCCCAAAAAGAGGAGTAACAAAATGTCATTTCTGAAAGAGGCTTACTTTATACCAACTAGTGTCAGCATTTGGGAT
1921 GCCAGGGAACAGAGAGTGAGACACCTACAATCACCAGTCTCAAATGCGCTATTGTTTCTTTTCAGAGTGTTGCAGATTTG
2001 CCATTTCTCCATAATATGGGGATAGAAAATGGAATAAAGATAGAAGGGATGTAGAATATGCTTTCCTGCCAACATGGTTT
2081 GGAGTCGACTTTGGTATATTGACTAGATTTGAAAATACAAGATTGATTAGATGAATCTACAAAAAAGTTGTCCTCCTCTC
2161 AGGTCCCTTTTACACTTTTTGACTAACTAGCATCTATATTCCACACTTAGCTTTTTTGTCACACTTATCCTTTGTCTCCG
2241 TAAATTTCATTTGCAGTGGTTAGTCATCAGATATTTTAGCCACCTACACAAAAGCAAACTGCATTTTTAAAAATCTTTCT
2321 GAGATGGGAGAAAATGTATTCTCCTTTCCTATACCGCTCTCCCAACAAAAAAACAACTAGTTAGTTCTACTAATTAGAAA
2401 CTTGCTGTACTTTTTCTTTTCTTTTAGGGGTCAAGGACCCTCTTTATAGCTACCATTTGCCTACAATAAATTATTGCAGC
2481 AGTTTGCAATACTAAAATATTTTTTATAGACTTTATATTTTTCCTTTTGATAAAGGGATGCTGCATAGTAGAGTTGGTGT
2561 AATTAAACTATCTCAGCCGTTTCCCTGCTTTCCCTTCTGCTCCATATGCCTCATTGTCCTTCCAGGGAGCTCTTTTAATC
2641 TTAAAGTTCTACATTTCATGCTCTTAGTCAAATTCTGTTACCTTTTTAATAACTCTTCCCACTGCATATTTCCATCTTGA
2721 ATTGGTGGTTCTAAATTCTGAAACTGTAGTTGAGATACAGCTATTTAATATTTCTGGGAGATGTGCATCCCTCTTCTTTG
2801 TGGTTGCCCAAGGTTGTTTTGCGTAACTGAGACTCCTTGATATGCTTCAGAGAATTTAGGCAAACACTGGCCATGGCCGT
2881 GGGAGTACTGGGAGTAAAATAAAAATATCGAGGTATAGACTAGCATCCACATAGAGCACTTGAACCTCCTTTGTACCTGT
2961 TTGGGGAAAAAGTATAATGAGTGTACTACCAATCTAACTAAGATTATTATAGTCTGGTTGTTTGAAATACCATTTTTTTC
3041 TCCTTTTGTGTTTTTCCCACTTTCCAATGTACTCAAGAAAATTGAACAAATGTAATGGATCAATTTAAAATATTTTATTT
3121 CTTAAAAGCCTTTTTTGCCTGTTGTAATGTGCAGGACCCTTCTCCTTTCATGGGAGAGACAGGTAGTTACCTGAATATAG
3201 GTTGAAAAGGTTATGTAAAAAGAAATTATAATAAAAGGGATACTTTGCTTTTCAAATCTTTGTTTTCTCTTATTCTAGGT
3281 AAGGCATATTAAAAATAAATATGTAAAGAAGAAAAATAAAAGTTGTCTTCATGGAAGCAACTTGTCTTCCTTGGTTGTAC
3361 TGAGTTACAGTTATCCTAGGGGTGAAACATGTGATGCTGCTAAGCAAACCAAATGCCCTCAGAACAGGTGTTATGTGGGG
3441 CATACTATTGTTTGCTTTTGTTGAGAATCAGGTGGTTAATTTTTGACTGTTCTTGATTTCTAATGCTGAAATGACATGAT
3521 TCTGTTATTCAGCAAACTTGGAAATCTTGATGTTTTGACAACTGCCTCCTAGGAAAACTGGCCATATGTTAATTAACCTA
3601 GTAGATGGAAAATTAAGGATTATGTGAGGTTAATTTTACCCTGATAATGACAAAACCTTGATAGCATTTAATATTAATAC
3681 TTCTTCTCAAAATTGAATGTTTATATCAAGTACTGATTTTTATTTTAAAAAAGAAAAAACTATAATCCTTCTGCCTTCCA
3761 AAAGCCATGCTGTGATAGCTGCCCAGGCTGCTCTGTTACATCTCCCATTTATTGTTTACTTTTATAAATTTGCTTCTAAG
3841 ATGGAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uaAGCUAC-UGAGUCAGAGAAGAa 5'
            |:| || |||:  |||:|||| 
Target 5' acTTGCTGTACTTTTTCTTTTCTt 3'
 2400 - 2423 149.00 -12.80
2 
miRNA  3' uaagCUAC-UG-AGUCAGAGAAGAa 5'
              |||| :| ||   ||||||| 
Target 5' gggaGATGTGCATC--CCTCTTCTt 3'
 2776 - 2798 147.00 -13.10
3 
miRNA  3' uaAGCUACUGAGUCAGAGAAGAa 5'
            |:| ||| |: ||:||||:| 
Target 5' tcTTG-TGAATTTGTTTCTTTTc 3'
 1226 - 1247 136.00 -9.80
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30486610 45 COSMIC
COSN1135139 72 COSMIC
COSN31484400 74 COSMIC
COSN30102238 88 COSMIC
COSN27005694 90 COSMIC
COSN30101274 107 COSMIC
COSN30451895 121 COSMIC
COSN31570408 158 COSMIC
COSN30482292 163 COSMIC
COSN1539090 275 COSMIC
COSN1539091 285 COSMIC
COSN31583916 311 COSMIC
COSN31528297 421 COSMIC
COSN24304035 444 COSMIC
COSN26853084 482 COSMIC
COSN31522822 546 COSMIC
COSN28648702 574 COSMIC
COSN22168552 582 COSMIC
COSN31545254 587 COSMIC
COSN30538939 618 COSMIC
COSN22168752 679 COSMIC
COSN25257107 703 COSMIC
COSN22167923 767 COSMIC
COSN31570900 770 COSMIC
COSN19617091 778 COSMIC
COSN22169184 863 COSMIC
COSN27510313 883 COSMIC
COSN20336685 893 COSMIC
COSN26329868 969 COSMIC
COSN19624004 999 COSMIC
COSN30701454 1018 COSMIC
COSN31490749 1021 COSMIC
COSN31488503 1139 COSMIC
COSN22537995 1178 COSMIC
COSN23022878 1190 COSMIC
COSN23022879 1191 COSMIC
COSN22703141 1217 COSMIC
COSN31488358 1248 COSMIC
COSN28873006 1258 COSMIC
COSN10089771 1264 COSMIC
COSN1539092 1296 COSMIC
COSN31488525 1304 COSMIC
COSN31538535 1356 COSMIC
COSN1539093 1593 COSMIC
COSN26425642 1741 COSMIC
COSN31551239 1790 COSMIC
COSN31520001 2087 COSMIC
COSN21578247 2126 COSMIC
COSN8282021 2342 COSMIC
COSN29466036 2665 COSMIC
COSN26671647 2803 COSMIC
COSN31591012 2809 COSMIC
COSN31529086 2910 COSMIC
COSN31484088 2911 COSMIC
COSN10089772 2951 COSMIC
COSN31517729 3309 COSMIC
rs3168135 999 GWAS
rs34193069 1619 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1410436678 5 dbSNP
rs1273926048 12 dbSNP
rs373830717 15 dbSNP
rs1202497446 22 dbSNP
rs1175455311 29 dbSNP
rs1271208731 31 dbSNP
rs762877638 31 dbSNP
rs1490653929 32 dbSNP
rs748612063 33 dbSNP
rs763983330 33 dbSNP
rs201747536 37 dbSNP
rs770306483 42 dbSNP
rs984122279 45 dbSNP
rs1476572703 47 dbSNP
rs751381593 50 dbSNP
rs1266891302 58 dbSNP
rs1199122786 59 dbSNP
rs1379005677 60 dbSNP
rs1015404361 62 dbSNP
rs1381440697 62 dbSNP
rs571879543 62 dbSNP
rs633713 63 dbSNP
rs1327585405 64 dbSNP
rs1460229182 66 dbSNP
rs1380927200 72 dbSNP
rs1393303166 79 dbSNP
rs1164479714 85 dbSNP
rs1424215648 88 dbSNP
rs963511723 100 dbSNP
rs909847691 106 dbSNP
rs1475776062 107 dbSNP
rs1242673834 115 dbSNP
rs770957864 118 dbSNP
rs1445090019 124 dbSNP
rs112569218 125 dbSNP
rs537569708 127 dbSNP
rs1358208111 134 dbSNP
rs552363338 140 dbSNP
rs1343704840 141 dbSNP
rs990730904 149 dbSNP
rs917871339 150 dbSNP
rs1215887442 151 dbSNP
rs141033205 154 dbSNP
rs1270183545 159 dbSNP
rs551295900 165 dbSNP
rs1333224407 167 dbSNP
rs774936853 169 dbSNP
rs1404585948 170 dbSNP
rs1364010677 177 dbSNP
rs1310052248 179 dbSNP
rs1410649625 180 dbSNP
rs1167294398 182 dbSNP
rs903465324 182 dbSNP
rs936443478 184 dbSNP
rs553295031 188 dbSNP
rs1000365042 190 dbSNP
rs1490123101 193 dbSNP
rs1266385256 206 dbSNP
rs1054325124 207 dbSNP
rs1343374399 216 dbSNP
rs1031975830 217 dbSNP
rs1206159695 218 dbSNP
rs1437931600 219 dbSNP
rs1271636078 222 dbSNP
rs900677307 223 dbSNP
rs1326203782 230 dbSNP
rs1223352800 238 dbSNP
rs996335083 238 dbSNP
rs574791363 247 dbSNP
rs1344001988 255 dbSNP
rs893509673 259 dbSNP
rs372493807 264 dbSNP
rs1354016197 266 dbSNP
rs188999101 272 dbSNP
rs1416226009 276 dbSNP
rs575713065 278 dbSNP
rs965127387 279 dbSNP
rs1480017021 291 dbSNP
rs1426887201 301 dbSNP
rs1178612555 302 dbSNP
rs1209931745 304 dbSNP
rs762681368 305 dbSNP
rs1231827609 308 dbSNP
rs1025441844 311 dbSNP
rs1426404692 315 dbSNP
rs545904286 320 dbSNP
rs984071770 321 dbSNP
rs557545839 322 dbSNP
rs1005268101 326 dbSNP
rs1014937776 329 dbSNP
rs1372940867 329 dbSNP
rs1277997625 332 dbSNP
rs1454683170 336 dbSNP
rs909797005 338 dbSNP
rs1383591724 351 dbSNP
rs1337339289 353 dbSNP
rs111492255 361 dbSNP
rs963756746 366 dbSNP
rs572909676 371 dbSNP
rs763714410 372 dbSNP
rs991492131 374 dbSNP
rs917335881 376 dbSNP
rs1401062219 377 dbSNP
rs973513698 379 dbSNP
rs1457428754 380 dbSNP
rs950140598 382 dbSNP
rs1445947173 396 dbSNP
rs1243174524 400 dbSNP
rs1183522462 402 dbSNP
rs1034470745 418 dbSNP
rs1294227651 420 dbSNP
rs959183402 421 dbSNP
rs1380720538 427 dbSNP
rs1042282065 431 dbSNP
rs903326879 433 dbSNP
rs936166752 435 dbSNP
rs540224091 437 dbSNP
rs561621928 438 dbSNP
rs949345565 439 dbSNP
rs889349336 440 dbSNP
rs529214417 444 dbSNP
rs1006998137 445 dbSNP
rs923634493 455 dbSNP
rs191897451 465 dbSNP
rs1221614399 466 dbSNP
rs562726758 470 dbSNP
rs1162434503 473 dbSNP
rs532962737 479 dbSNP
rs552675295 480 dbSNP
rs1264526444 488 dbSNP
rs1187588625 492 dbSNP
rs570605090 497 dbSNP
rs1485760476 499 dbSNP
rs997909622 501 dbSNP
rs184146060 504 dbSNP
rs1484636224 505 dbSNP
rs900289718 506 dbSNP
rs188484588 511 dbSNP
rs1309301790 514 dbSNP
rs1248331243 518 dbSNP
rs546588804 527 dbSNP
rs1016889656 538 dbSNP
rs758504082 544 dbSNP
rs1384491674 545 dbSNP
rs1406529656 549 dbSNP
rs774774448 550 dbSNP
rs1302106261 553 dbSNP
rs11541682 574 dbSNP
rs1374243219 574 dbSNP
rs1171772254 577 dbSNP
rs368286008 578 dbSNP
rs1034418299 579 dbSNP
rs1202119188 579 dbSNP
rs1220511130 584 dbSNP
rs1370253033 588 dbSNP
rs991918375 599 dbSNP
rs1251893484 600 dbSNP
rs1205151270 605 dbSNP
rs1012060571 609 dbSNP
rs200272771 614 dbSNP
rs1276217457 616 dbSNP
rs77137146 620 dbSNP
rs1345884015 621 dbSNP
rs557341875 633 dbSNP
rs569461379 636 dbSNP
rs977509730 637 dbSNP
rs1389672132 642 dbSNP
rs1398018756 643 dbSNP
rs150280738 645 dbSNP
rs536802913 647 dbSNP
rs1348172097 648 dbSNP
rs957715252 649 dbSNP
rs1054541100 651 dbSNP
rs1197028622 653 dbSNP
rs1421044355 655 dbSNP
rs989129384 658 dbSNP
rs1195368920 661 dbSNP
rs1479678426 672 dbSNP
rs557925765 674 dbSNP
rs943592232 675 dbSNP
rs1314609803 682 dbSNP
rs1039782755 692 dbSNP
rs900867978 695 dbSNP
rs998257282 697 dbSNP
rs572972321 699 dbSNP
rs1262205493 702 dbSNP
rs1230630542 705 dbSNP
rs1337226953 706 dbSNP
rs1268306320 712 dbSNP
rs912065149 716 dbSNP
rs1046871352 718 dbSNP
rs1373987448 723 dbSNP
rs886843394 725 dbSNP
rs372373981 727 dbSNP
rs1470549856 732 dbSNP
rs1405823723 734 dbSNP
rs899438527 734 dbSNP
rs1455668988 736 dbSNP
rs1483487346 736 dbSNP
rs180888135 742 dbSNP
rs958876441 746 dbSNP
rs1364637177 752 dbSNP
rs1437925127 755 dbSNP
rs1012802527 769 dbSNP
rs1185354483 769 dbSNP
rs1461670440 770 dbSNP
rs1248330291 783 dbSNP
rs1198586952 785 dbSNP
rs1417331733 786 dbSNP
rs994827036 790 dbSNP
rs1158545012 791 dbSNP
rs1237823665 793 dbSNP
rs1055819895 811 dbSNP
rs1316457143 814 dbSNP
rs1452707603 817 dbSNP
rs894530899 820 dbSNP
rs1014352370 825 dbSNP
rs1024635435 827 dbSNP
rs1386067820 829 dbSNP
rs555418595 834 dbSNP
rs573529673 839 dbSNP
rs1449304143 848 dbSNP
rs977377122 850 dbSNP
rs753920244 858 dbSNP
rs1030899839 860 dbSNP
rs1371830688 869 dbSNP
rs11426880 871 dbSNP
rs1262121558 871 dbSNP
rs386373882 871 dbSNP
rs878928671 871 dbSNP
rs1215460187 873 dbSNP
rs1487136001 878 dbSNP
rs577883097 880 dbSNP
rs1246121534 881 dbSNP
rs1288395030 882 dbSNP
rs1330664027 884 dbSNP
rs1230209216 885 dbSNP
rs989077083 886 dbSNP
rs1277556428 889 dbSNP
rs1318006155 892 dbSNP
rs921610067 893 dbSNP
rs990278355 894 dbSNP
rs1211985366 895 dbSNP
rs1367763742 898 dbSNP
rs1249492981 899 dbSNP
rs1480288734 901 dbSNP
rs910685575 906 dbSNP
rs1411662117 915 dbSNP
rs1252602736 917 dbSNP
rs1476314902 922 dbSNP
rs1436525320 926 dbSNP
rs773757117 927 dbSNP
rs1373557624 929 dbSNP
rs1407917818 930 dbSNP
rs868355847 940 dbSNP
rs943523581 941 dbSNP
rs761648917 942 dbSNP
rs1192752314 945 dbSNP
rs1306082017 947 dbSNP
rs953092444 948 dbSNP
rs976399128 955 dbSNP
rs1222706353 957 dbSNP
rs544525396 959 dbSNP
rs767315460 959 dbSNP
rs763271804 961 dbSNP
rs923498473 962 dbSNP
rs1450570118 963 dbSNP
rs755221218 964 dbSNP
rs185936283 966 dbSNP
rs1328158036 967 dbSNP
rs911662696 969 dbSNP
rs750112172 979 dbSNP
rs1491467274 980 dbSNP
rs190465235 982 dbSNP
rs139343104 983 dbSNP
rs1226547086 994 dbSNP
rs920829734 995 dbSNP
rs886874496 996 dbSNP
rs3168135 999 dbSNP
rs1221886211 1001 dbSNP
rs1331038727 1003 dbSNP
rs1265850316 1004 dbSNP
rs1410598072 1005 dbSNP
rs1397171599 1008 dbSNP
rs1169841211 1010 dbSNP
rs1449282994 1012 dbSNP
rs1194333133 1015 dbSNP
rs1241967137 1021 dbSNP
rs1474634378 1022 dbSNP
rs1055766588 1027 dbSNP
rs1349357213 1027 dbSNP
rs1184989238 1029 dbSNP
rs894478518 1031 dbSNP
rs1385500617 1034 dbSNP
rs937929239 1041 dbSNP
rs894343411 1061 dbSNP
rs1045802550 1066 dbSNP
rs182293505 1076 dbSNP
rs999342474 1078 dbSNP
rs1264074004 1080 dbSNP
rs1031265013 1081 dbSNP
rs1365835073 1084 dbSNP
rs1281457732 1085 dbSNP
rs1277944346 1095 dbSNP
rs1024252063 1096 dbSNP
rs907103646 1098 dbSNP
rs1293141929 1117 dbSNP
rs1341262381 1119 dbSNP
rs1463937610 1122 dbSNP
rs559871974 1123 dbSNP
rs998827117 1125 dbSNP
rs1176963206 1137 dbSNP
rs1413697707 1139 dbSNP
rs117899798 1141 dbSNP
rs1028904154 1143 dbSNP
rs953039949 1148 dbSNP
rs781234116 1154 dbSNP
rs987123666 1156 dbSNP
rs1463003925 1167 dbSNP
rs1018676271 1171 dbSNP
rs1209903390 1176 dbSNP
rs1310780755 1183 dbSNP
rs745803555 1190 dbSNP
rs990225822 1194 dbSNP
rs1018101474 1202 dbSNP
rs1449311349 1203 dbSNP
rs1307102598 1215 dbSNP
rs1384990869 1218 dbSNP
rs769373188 1218 dbSNP
rs1303329991 1221 dbSNP
rs972226666 1226 dbSNP
rs1357166404 1239 dbSNP
rs779604272 1245 dbSNP
rs1400864572 1249 dbSNP
rs370355285 1249 dbSNP
rs564184056 1249 dbSNP
rs930839258 1249 dbSNP
rs976643688 1259 dbSNP
rs923559244 1263 dbSNP
rs916195417 1268 dbSNP
rs1322336700 1273 dbSNP
rs950013449 1282 dbSNP
rs546652037 1284 dbSNP
rs748816793 1285 dbSNP
rs982447626 1290 dbSNP
rs1350007292 1302 dbSNP
rs1244129182 1307 dbSNP
rs1216789829 1308 dbSNP
rs908175323 1312 dbSNP
rs1046166215 1314 dbSNP
rs1284138117 1319 dbSNP
rs370793290 1319 dbSNP
rs568136284 1323 dbSNP
rs1248314653 1331 dbSNP
rs768323956 1332 dbSNP
rs1038162813 1340 dbSNP
rs894201482 1342 dbSNP
rs903238831 1358 dbSNP
rs934749727 1362 dbSNP
rs1290358592 1365 dbSNP
rs1400370649 1366 dbSNP
rs1359542104 1385 dbSNP
rs529252629 1386 dbSNP
rs1268110870 1391 dbSNP
rs551292749 1391 dbSNP
rs1045946136 1393 dbSNP
rs1164696753 1394 dbSNP
rs893637218 1410 dbSNP
rs1228875899 1414 dbSNP
rs1187537381 1425 dbSNP
rs907138277 1427 dbSNP
rs1299659847 1430 dbSNP
rs1010726634 1434 dbSNP
rs1490543572 1436 dbSNP
rs1028851997 1440 dbSNP
rs1357221479 1442 dbSNP
rs143464809 1449 dbSNP
rs1031540991 1456 dbSNP
rs1319918328 1459 dbSNP
rs893175781 1464 dbSNP
rs1219058217 1470 dbSNP
rs11229545 1472 dbSNP
rs1275941889 1477 dbSNP
rs1406320115 1480 dbSNP
rs961782859 1481 dbSNP
rs1452314079 1482 dbSNP
rs972223590 1491 dbSNP
rs1356831440 1492 dbSNP
rs1027441119 1493 dbSNP
rs372460058 1495 dbSNP
rs1465455003 1503 dbSNP
rs1017717146 1508 dbSNP
rs1480855320 1518 dbSNP
rs965127916 1528 dbSNP
rs976294422 1534 dbSNP
rs1189633398 1536 dbSNP
rs916142743 1542 dbSNP
rs1392522547 1545 dbSNP
rs1030876255 1547 dbSNP
rs1255852576 1551 dbSNP
rs1443285698 1555 dbSNP
rs1163242602 1556 dbSNP
rs1413873867 1558 dbSNP
rs1384622554 1564 dbSNP
rs950292986 1569 dbSNP
rs145767734 1586 dbSNP
rs1332666263 1587 dbSNP
rs950953002 1592 dbSNP
rs983739838 1601 dbSNP
rs1179111513 1608 dbSNP
rs1466873227 1609 dbSNP
rs1387470572 1610 dbSNP
rs909461545 1612 dbSNP
rs993751665 1616 dbSNP
rs567036093 1617 dbSNP
rs533895346 1618 dbSNP
rs34193069 1619 dbSNP
rs915679040 1621 dbSNP
rs772458560 1626 dbSNP
rs573614733 1627 dbSNP
rs1357060200 1634 dbSNP
rs1457306349 1635 dbSNP
rs1230111480 1638 dbSNP
rs1221699166 1646 dbSNP
rs1345424819 1646 dbSNP
rs1255076176 1648 dbSNP
rs1266415088 1652 dbSNP
rs1230565326 1663 dbSNP
rs537432240 1664 dbSNP
rs1309285964 1665 dbSNP
rs1054938938 1669 dbSNP
rs773644974 1676 dbSNP
rs928503681 1680 dbSNP
rs1328783871 1684 dbSNP
rs934491003 1685 dbSNP
rs1401891351 1702 dbSNP
rs1250268175 1704 dbSNP
rs1050238381 1706 dbSNP
rs556466122 1707 dbSNP
rs1158195151 1711 dbSNP
rs1437870368 1713 dbSNP
rs112810779 1720 dbSNP
rs893041628 1722 dbSNP
rs3168136 1723 dbSNP
rs761154369 1724 dbSNP
rs574884569 1730 dbSNP
rs1255140105 1735 dbSNP
rs1156346013 1736 dbSNP
rs1198386666 1741 dbSNP
rs577860184 1745 dbSNP
rs544866009 1751 dbSNP
rs1286282976 1756 dbSNP
rs1160998149 1758 dbSNP
rs1238851685 1768 dbSNP
rs1039421567 1769 dbSNP
rs778342908 1773 dbSNP
rs1246079237 1774 dbSNP
rs1340260244 1776 dbSNP
rs1413703963 1777 dbSNP
rs1009234189 1778 dbSNP
rs1297798118 1778 dbSNP
rs1311097492 1778 dbSNP
rs58832807 1778 dbSNP
rs2509925 1779 dbSNP
rs997976049 1784 dbSNP
rs1367486492 1788 dbSNP
rs544145925 1789 dbSNP
rs1473053537 1791 dbSNP
rs897478882 1798 dbSNP
rs1478663925 1799 dbSNP
rs1263521979 1810 dbSNP
rs1334670237 1813 dbSNP
rs950900837 1821 dbSNP
rs1005036859 1824 dbSNP
rs1291328152 1833 dbSNP
rs1016557137 1836 dbSNP
rs1209895509 1838 dbSNP
rs1286496156 1840 dbSNP
rs559933491 1842 dbSNP
rs538931734 1847 dbSNP
rs1264170374 1852 dbSNP
rs963597418 1868 dbSNP
rs1230138397 1873 dbSNP
rs571884027 1885 dbSNP
rs1277839433 1886 dbSNP
rs1398312184 1888 dbSNP
rs753919586 1898 dbSNP
rs1404840655 1904 dbSNP
rs951795322 1915 dbSNP
rs747412506 1923 dbSNP
rs1423984279 1928 dbSNP
rs538605910 1937 dbSNP
rs1476667527 1943 dbSNP
rs186001023 1944 dbSNP
rs1279894390 1945 dbSNP
rs1450513069 1951 dbSNP
rs1265907816 1953 dbSNP
rs1201029337 1966 dbSNP
rs1319042429 1968 dbSNP
rs934522066 1969 dbSNP
rs1444667397 1984 dbSNP
rs1326004305 1988 dbSNP
rs765449102 1991 dbSNP
rs914508724 2008 dbSNP
rs1435914204 2012 dbSNP
rs1329371976 2018 dbSNP
rs1321543554 2021 dbSNP
rs971599146 2024 dbSNP
rs1400921177 2025 dbSNP
rs1049622682 2026 dbSNP
rs947251855 2037 dbSNP
rs1426888213 2038 dbSNP
rs1039041366 2048 dbSNP
rs561831876 2049 dbSNP
rs1244407697 2051 dbSNP
rs956219259 2054 dbSNP
rs900536559 2066 dbSNP
rs1238099801 2068 dbSNP
rs529329192 2074 dbSNP
rs758607999 2079 dbSNP
rs1051873422 2085 dbSNP
rs1444469169 2087 dbSNP
rs886511443 2088 dbSNP
rs1005069744 2099 dbSNP
rs1218830622 2100 dbSNP
rs1375584273 2104 dbSNP
rs550697775 2105 dbSNP
rs1465314452 2116 dbSNP
rs149275040 2119 dbSNP
rs963627590 2121 dbSNP
rs11229546 2123 dbSNP
rs910386014 2127 dbSNP
rs944592800 2147 dbSNP
rs552074582 2148 dbSNP
rs1444331990 2149 dbSNP
rs970150855 2151 dbSNP
rs1410525905 2155 dbSNP
rs1334405037 2156 dbSNP
rs144480299 2161 dbSNP
rs1422604659 2165 dbSNP
rs1035415573 2167 dbSNP
rs1160005034 2174 dbSNP
rs554394811 2182 dbSNP
rs1275781798 2184 dbSNP
rs369179334 2187 dbSNP
rs1203626641 2189 dbSNP
rs1473998906 2197 dbSNP
rs1274556337 2199 dbSNP
rs1048773206 2203 dbSNP
rs1440971079 2204 dbSNP
rs1288387069 2205 dbSNP
rs1483063725 2212 dbSNP
rs1353014264 2213 dbSNP
rs1308485792 2218 dbSNP
rs113311187 2221 dbSNP
rs757043687 2224 dbSNP
rs567244324 2225 dbSNP
rs1003070111 2227 dbSNP
rs1373283477 2228 dbSNP
rs781147615 2229 dbSNP
rs11229547 2237 dbSNP
rs1379136994 2238 dbSNP
rs990526715 2239 dbSNP
rs555892499 2240 dbSNP
rs373300620 2241 dbSNP
rs538570136 2244 dbSNP
rs1181675919 2245 dbSNP
rs1300001792 2252 dbSNP
rs886542855 2253 dbSNP
rs1265638555 2257 dbSNP
rs1388717417 2258 dbSNP
rs940719222 2265 dbSNP
rs553630682 2267 dbSNP
rs1283900744 2271 dbSNP
rs1037883763 2272 dbSNP
rs899366555 2273 dbSNP
rs1012395445 2275 dbSNP
rs756117802 2278 dbSNP
rs540387388 2287 dbSNP
rs1227583792 2290 dbSNP
rs1279736256 2291 dbSNP
rs1002511450 2292 dbSNP
rs975960143 2302 dbSNP
rs1478704689 2304 dbSNP
rs1339296668 2306 dbSNP
rs1286676398 2314 dbSNP
rs1035279081 2316 dbSNP
rs1351022282 2319 dbSNP
rs1164629889 2330 dbSNP
rs1403982538 2332 dbSNP
rs929248074 2339 dbSNP
rs1171668874 2341 dbSNP
rs779897315 2342 dbSNP
rs1261300303 2344 dbSNP
rs190457336 2356 dbSNP
rs988553856 2357 dbSNP
rs1021327189 2364 dbSNP
rs2276156 2366 dbSNP
rs1332423401 2367 dbSNP
rs974590988 2374 dbSNP
rs1219005048 2377 dbSNP
rs1044154678 2378 dbSNP
rs1292966543 2378 dbSNP
rs778592322 2379 dbSNP
rs933230526 2380 dbSNP
rs1367645659 2381 dbSNP
rs1003427533 2382 dbSNP
rs2276155 2385 dbSNP
rs747806155 2388 dbSNP
rs907844203 2390 dbSNP
rs1210061717 2406 dbSNP
rs146042742 2407 dbSNP
rs544658617 2408 dbSNP
rs1011783024 2410 dbSNP
rs1021869644 2411 dbSNP
rs1433877115 2411 dbSNP
rs954034799 2415 dbSNP
rs1190567328 2421 dbSNP
rs1467131113 2423 dbSNP
rs985450404 2426 dbSNP
rs1199087442 2429 dbSNP
rs1457113487 2430 dbSNP
rs899231977 2431 dbSNP
rs1234878313 2432 dbSNP
rs1020093452 2434 dbSNP
rs948232207 2437 dbSNP
rs1187727151 2441 dbSNP
rs139974184 2443 dbSNP
rs1379815533 2444 dbSNP
rs906779744 2455 dbSNP
rs976286874 2461 dbSNP
rs769542821 2463 dbSNP
rs775475176 2471 dbSNP
rs1394737181 2472 dbSNP
rs919099078 2477 dbSNP
rs1003716336 2486 dbSNP
rs1031204836 2494 dbSNP
rs34967301 2494 dbSNP
rs1466696122 2498 dbSNP
rs929168793 2500 dbSNP
rs749082151 2507 dbSNP
rs1423280986 2508 dbSNP
rs1162657712 2509 dbSNP
rs1382116853 2510 dbSNP
rs377667845 2511 dbSNP
rs948347294 2512 dbSNP
rs370960371 2515 dbSNP
rs552135965 2516 dbSNP
rs569580615 2531 dbSNP
rs761066378 2535 dbSNP
rs1255021031 2539 dbSNP
rs996432091 2546 dbSNP
rs560756115 2548 dbSNP
rs1028788485 2549 dbSNP
rs1366431952 2550 dbSNP
rs545165704 2554 dbSNP
rs549599021 2569 dbSNP
rs777023474 2579 dbSNP
rs1315348707 2584 dbSNP
rs1396973200 2585 dbSNP
rs1401823306 2600 dbSNP
rs1311288996 2604 dbSNP
rs907773433 2610 dbSNP
rs181349125 2614 dbSNP
rs1244904486 2616 dbSNP
rs1361171240 2617 dbSNP
rs1159205165 2620 dbSNP
rs1453031521 2621 dbSNP
rs1266799132 2624 dbSNP
rs1326679900 2630 dbSNP
rs143441472 2631 dbSNP
rs1424161785 2633 dbSNP
rs770341297 2633 dbSNP
rs920692783 2652 dbSNP
rs1489001188 2662 dbSNP
rs1466134549 2663 dbSNP
rs948123281 2664 dbSNP
rs549822270 2668 dbSNP
rs1179976490 2670 dbSNP
rs571185240 2676 dbSNP
rs1246007590 2683 dbSNP
rs1340179150 2683 dbSNP
rs1045646292 2689 dbSNP
rs1291702728 2691 dbSNP
rs1402029570 2694 dbSNP
rs965804580 2697 dbSNP
rs928188084 2699 dbSNP
rs765236419 2707 dbSNP
rs1380600027 2714 dbSNP
rs1255401902 2715 dbSNP
rs1164865799 2721 dbSNP
rs994260460 2729 dbSNP
rs1416843916 2733 dbSNP
rs1162374362 2745 dbSNP
rs146792368 2749 dbSNP
rs892706790 2764 dbSNP
rs1263413080 2768 dbSNP
rs950517461 2781 dbSNP
rs1444724213 2782 dbSNP
rs1009872544 2784 dbSNP
rs1210919792 2788 dbSNP
rs553692063 2790 dbSNP
rs1334638955 2798 dbSNP
rs1271722295 2811 dbSNP
rs1042707367 2812 dbSNP
rs752907999 2816 dbSNP
rs796101665 2823 dbSNP
rs139239525 2824 dbSNP
rs1332837262 2826 dbSNP
rs1029153848 2833 dbSNP
rs185486898 2836 dbSNP
rs1008720772 2837 dbSNP
rs1323688169 2841 dbSNP
rs1466984605 2844 dbSNP
rs938383073 2846 dbSNP
rs1166894293 2847 dbSNP
rs1474160845 2849 dbSNP
rs1014860083 2850 dbSNP
rs1379115296 2861 dbSNP
rs554477815 2866 dbSNP
rs961931549 2874 dbSNP
rs150017553 2877 dbSNP
rs377691615 2879 dbSNP
rs912999113 2880 dbSNP
rs1272566647 2883 dbSNP
rs947535100 2885 dbSNP
rs1275563320 2886 dbSNP
rs1043219818 2888 dbSNP
rs1370237036 2892 dbSNP
rs189952346 2909 dbSNP
rs1448729577 2910 dbSNP
rs1400713839 2911 dbSNP
rs1007100184 2913 dbSNP
rs751879228 2916 dbSNP
rs928020930 2917 dbSNP
rs1403867707 2919 dbSNP
rs939551397 2920 dbSNP
rs557398858 2921 dbSNP
rs1052524529 2924 dbSNP
rs1183572463 2930 dbSNP
rs1393823726 2931 dbSNP
rs914174395 2946 dbSNP
rs1440730087 2949 dbSNP
rs750211629 2954 dbSNP
rs1202836638 2963 dbSNP
rs1025708995 2966 dbSNP
rs952789225 2968 dbSNP
rs1006027968 2971 dbSNP
rs1016111351 2972 dbSNP
rs1242171792 2972 dbSNP
rs1373941900 2973 dbSNP
rs1181644142 2974 dbSNP
rs1278781482 2974 dbSNP
rs969922909 2986 dbSNP
rs1334338973 2989 dbSNP
rs980036910 2992 dbSNP
rs774358338 2993 dbSNP
rs530881923 2994 dbSNP
rs1174441118 2998 dbSNP
rs1420885955 3004 dbSNP
rs1043124466 3010 dbSNP
rs761605049 3013 dbSNP
rs1473969352 3016 dbSNP
rs538145600 3019 dbSNP
rs1187450447 3024 dbSNP
rs1484746949 3028 dbSNP
rs1064446 3029 dbSNP
rs578099945 3030 dbSNP
rs1217396789 3032 dbSNP
rs373393788 3033 dbSNP
rs1368161237 3038 dbSNP
rs947146360 3041 dbSNP
rs1283460067 3048 dbSNP
rs866815177 3049 dbSNP
rs1358121315 3060 dbSNP
rs755911786 3061 dbSNP
rs545415003 3062 dbSNP
rs1375114258 3065 dbSNP
rs1217157624 3068 dbSNP
rs145240560 3072 dbSNP
rs1430817079 3073 dbSNP
rs1345175181 3087 dbSNP
rs527997083 3089 dbSNP
rs901445440 3091 dbSNP
rs994158073 3099 dbSNP
rs766295397 3103 dbSNP
rs1164635545 3104 dbSNP
rs543268572 3109 dbSNP
rs149203230 3111 dbSNP
rs1482083123 3113 dbSNP
rs1485551831 3126 dbSNP
rs1241452225 3130 dbSNP
rs1204557354 3133 dbSNP
rs1453134383 3137 dbSNP
rs1252765294 3138 dbSNP
rs1481725310 3139 dbSNP
rs1189745269 3140 dbSNP
rs1027982349 3141 dbSNP
rs1424886668 3142 dbSNP
rs1434185872 3145 dbSNP
rs531914719 3148 dbSNP
rs373604336 3150 dbSNP
rs1035081148 3161 dbSNP
rs1279683391 3162 dbSNP
rs747239280 3167 dbSNP
rs1360578978 3171 dbSNP
rs1287657693 3184 dbSNP
rs1439287128 3186 dbSNP
rs905683027 3187 dbSNP
rs1308080159 3190 dbSNP
rs1001799970 3191 dbSNP
rs1171572005 3192 dbSNP
rs1035591221 3198 dbSNP
rs1417404801 3200 dbSNP
rs960242252 3210 dbSNP
rs1489445674 3211 dbSNP
rs1253541787 3216 dbSNP
rs988271349 3218 dbSNP
rs1466922533 3229 dbSNP
rs1259592665 3230 dbSNP
rs1204723014 3231 dbSNP
rs1418089120 3234 dbSNP
rs1292876384 3256 dbSNP
rs1220450867 3276 dbSNP
rs1433831657 3278 dbSNP
rs1303242857 3279 dbSNP
rs1292649435 3284 dbSNP
rs182633993 3288 dbSNP
rs1439165162 3291 dbSNP
rs1367957906 3301 dbSNP
rs914040474 3303 dbSNP
rs1461716141 3306 dbSNP
rs1178408224 3312 dbSNP
rs2507762 3312 dbSNP
rs979750512 3316 dbSNP
rs1395623742 3323 dbSNP
rs921499910 3328 dbSNP
rs588091 3340 dbSNP
rs1239834710 3345 dbSNP
rs1177542343 3346 dbSNP
rs1480145854 3357 dbSNP
rs1019912189 3370 dbSNP
rs1341410052 3375 dbSNP
rs879499315 3378 dbSNP
rs1280278656 3381 dbSNP
rs1232681193 3388 dbSNP
rs1229109847 3389 dbSNP
rs760495225 3389 dbSNP
rs931678544 3390 dbSNP
rs968395870 3395 dbSNP
rs1371521568 3400 dbSNP
rs1304745876 3402 dbSNP
rs1435417905 3405 dbSNP
rs1050488359 3413 dbSNP
rs549901410 3420 dbSNP
rs910998594 3426 dbSNP
rs1219641561 3428 dbSNP
rs1182332606 3429 dbSNP
rs1418231656 3432 dbSNP
rs1247987656 3435 dbSNP
rs879107857 3437 dbSNP
rs942864104 3448 dbSNP
rs1485725906 3451 dbSNP
rs890211429 3456 dbSNP
rs532027260 3460 dbSNP
rs977343245 3463 dbSNP
rs1488979340 3473 dbSNP
rs113319835 3474 dbSNP
rs1246614800 3475 dbSNP
rs930226434 3486 dbSNP
rs1449369238 3491 dbSNP
rs1355030839 3493 dbSNP
rs776658535 3503 dbSNP
rs1036105161 3504 dbSNP
rs567926493 3516 dbSNP
rs897700244 3522 dbSNP
rs888444685 3524 dbSNP
rs1361542902 3528 dbSNP
rs995061274 3528 dbSNP
rs1421016527 3529 dbSNP
rs1416707344 3531 dbSNP
rs1185236724 3545 dbSNP
rs941372074 3561 dbSNP
rs1403097460 3566 dbSNP
rs1045157745 3567 dbSNP
rs546992854 3569 dbSNP
rs1350134595 3571 dbSNP
rs905298624 3579 dbSNP
rs187760493 3580 dbSNP
rs192061424 3581 dbSNP
rs1291609499 3582 dbSNP
rs1027601646 3583 dbSNP
rs905080923 3615 dbSNP
rs1318919403 3624 dbSNP
rs1442782027 3625 dbSNP
rs1382653592 3630 dbSNP
rs555176918 3651 dbSNP
rs754446215 3652 dbSNP
rs1034945989 3658 dbSNP
rs960788286 3659 dbSNP
rs1162260122 3661 dbSNP
rs1476123757 3663 dbSNP
rs1010568156 3666 dbSNP
rs1271928179 3673 dbSNP
rs1020193320 3680 dbSNP
rs988220957 3681 dbSNP
rs1427331524 3682 dbSNP
rs1226696916 3683 dbSNP
rs968340454 3686 dbSNP
rs1289374827 3689 dbSNP
rs536162703 3694 dbSNP
rs1335684371 3699 dbSNP
rs1197724450 3701 dbSNP
rs1215841405 3702 dbSNP
rs1266611564 3704 dbSNP
rs1269716640 3706 dbSNP
rs964147361 3726 dbSNP
rs1194434471 3729 dbSNP
rs1305459740 3731 dbSNP
rs1441372981 3733 dbSNP
rs1393401964 3734 dbSNP
rs1323505281 3737 dbSNP
rs1244347276 3740 dbSNP
rs1396766970 3740 dbSNP
rs1411349167 3740 dbSNP
rs1166872806 3742 dbSNP
rs115650357 3743 dbSNP
rs968270798 3752 dbSNP
rs1194762520 3771 dbSNP
rs922761506 3776 dbSNP
rs1251577586 3780 dbSNP
rs1184389009 3786 dbSNP
rs367652540 3788 dbSNP
rs1438674936 3801 dbSNP
rs1272543412 3804 dbSNP
rs930197397 3815 dbSNP
rs1350055770 3819 dbSNP
rs1282418469 3820 dbSNP
rs1234864950 3823 dbSNP
rs1370125985 3825 dbSNP
rs979978980 3829 dbSNP
rs983022897 3831 dbSNP
rs921546031 3832 dbSNP
rs1335998646 3834 dbSNP
rs778303473 3839 dbSNP
rs932855409 3845 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177600. RNA binding protein: AGO2. Condition:p53_V_Ago_CLIP_2_2 PAR-CLIP data was present in ERX177612. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_3_2 PAR-CLIP data was present in ERX177624. RNA binding protein: AGO2. Condition:p53_V_AGO_CLIP_4_2 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000316059.6 | 3UTR | UCUUCUAAAUCCCUUCUCCUCCUCUACUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
130 hsa-miR-5197-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055372 PDCD4 programmed cell death 4 2 4
MIRT063381 ETNK1 ethanolamine kinase 1 2 2
MIRT068048 SAP18 Sin3A associated protein 18 2 6
MIRT070247 FRMD6 FERM domain containing 6 2 2
MIRT088320 RAB10 RAB10, member RAS oncogene family 2 4
MIRT097550 VCAN versican 2 2
MIRT130055 TRAF6 TNF receptor associated factor 6 2 2
MIRT164190 SCOC short coiled-coil protein 2 2
MIRT183552 BTG2 BTG anti-proliferation factor 2 2 4
MIRT194954 TNRC6A trinucleotide repeat containing 6A 2 2
MIRT199034 POLI DNA polymerase iota 2 2
MIRT200619 BCL3 B-cell CLL/lymphoma 3 2 2
MIRT231349 SERPINH1 serpin family H member 1 2 2
MIRT243305 SLC25A36 solute carrier family 25 member 36 2 2
MIRT270950 GPRC5A G protein-coupled receptor class C group 5 member A 2 2
MIRT295297 BTBD3 BTB domain containing 3 2 6
MIRT295775 MAPRE1 microtubule associated protein RP/EB family member 1 2 2
MIRT297115 GCC2 GRIP and coiled-coil domain containing 2 2 6
MIRT333632 ZFP91 ZFP91 zinc finger protein 2 2
MIRT338923 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT344878 WIPF2 WAS/WASL interacting protein family member 2 2 2
MIRT352038 BZW1 basic leucine zipper and W2 domains 1 2 4
MIRT360289 HIST1H3E histone cluster 1 H3 family member e 2 2
MIRT362931 CLDN12 claudin 12 2 2
MIRT375251 MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 2 4
MIRT405442 RAB5B RAB5B, member RAS oncogene family 2 2
MIRT442511 OSBP oxysterol binding protein 2 2
MIRT443281 TSPAN15 tetraspanin 15 2 2
MIRT443379 PLXNA2 plexin A2 2 2
MIRT443900 NUTM2E NUT family member 2E 2 2
MIRT445537 MOG myelin oligodendrocyte glycoprotein 2 2
MIRT446235 C17orf80 chromosome 17 open reading frame 80 2 2
MIRT446962 ZNF431 zinc finger protein 431 2 2
MIRT447545 RNF165 ring finger protein 165 2 2
MIRT447686 MTPAP mitochondrial poly(A) polymerase 2 2
MIRT450499 LIMD2 LIM domain containing 2 2 2
MIRT451257 ZNF444 zinc finger protein 444 2 2
MIRT453934 COMMD5 COMM domain containing 5 2 4
MIRT454042 DDT D-dopachrome tautomerase 2 2
MIRT454549 RABL2A RAB, member of RAS oncogene family like 2A 2 2
MIRT456455 TMEM81 transmembrane protein 81 2 2
MIRT456546 TMEM63A transmembrane protein 63A 2 2
MIRT456614 SFMBT2 Scm like with four mbt domains 2 2 2
MIRT456634 ARMCX6 armadillo repeat containing, X-linked 6 2 2
MIRT457258 RABL2B RAB, member of RAS oncogene family like 2B 2 2
MIRT458092 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT458210 FOXL2 forkhead box L2 2 2
MIRT458459 RPRM reprimo, TP53 dependent G2 arrest mediator homolog 2 2
MIRT458700 LEPREL1 prolyl 3-hydroxylase 2 1 1
MIRT461649 ZSWIM4 zinc finger SWIM-type containing 4 2 2
MIRT461996 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT462237 PRSS16 protease, serine 16 2 2
MIRT464774 UBE2G1 ubiquitin conjugating enzyme E2 G1 2 2
MIRT465051 TTC14 tetratricopeptide repeat domain 14 2 2
MIRT465393 TPD52L2 tumor protein D52 like 2 2 2
MIRT467612 SLC7A5 solute carrier family 7 member 5 2 2
MIRT467938 SLC16A6 solute carrier family 16 member 6 2 2
MIRT470022 PTP4A2 protein tyrosine phosphatase type IVA, member 2 2 2
MIRT470049 PTGFRN prostaglandin F2 receptor inhibitor 2 2
MIRT470514 PPP1R11 protein phosphatase 1 regulatory inhibitor subunit 11 2 2
MIRT471073 PIM2 Pim-2 proto-oncogene, serine/threonine kinase 2 2
MIRT471610 PAQR5 progestin and adipoQ receptor family member 5 2 18
MIRT472026 NPM1 nucleophosmin 1 2 2
MIRT474358 KMT2D lysine methyltransferase 2D 2 2
MIRT474681 KLF10 Kruppel like factor 10 2 2
MIRT474878 KDELR1 KDEL endoplasmic reticulum protein retention receptor 1 2 2
MIRT477137 FAM107B family with sequence similarity 107 member B 2 6
MIRT477850 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT477922 DUSP2 dual specificity phosphatase 2 2 2
MIRT479772 CCND1 cyclin D1 2 2
MIRT480108 CALR calreticulin 2 2
MIRT482161 AK2 adenylate kinase 2 2 2
MIRT482232 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT483455 ARHGEF6 Rac/Cdc42 guanine nucleotide exchange factor 6 2 4
MIRT487256 KHSRP KH-type splicing regulatory protein 2 2
MIRT488677 SPAM1 sperm adhesion molecule 1 2 2
MIRT488930 GFRAL GDNF family receptor alpha like 2 2
MIRT489980 DDB1 damage specific DNA binding protein 1 2 2
MIRT492360 SEMA7A semaphorin 7A (John Milton Hagen blood group) 2 2
MIRT493688 HAP1 huntingtin associated protein 1 2 2
MIRT497165 BBX BBX, HMG-box containing 2 2
MIRT498884 ZNF12 zinc finger protein 12 2 10
MIRT500182 CHRM3 cholinergic receptor muscarinic 3 2 2
MIRT501904 MED13 mediator complex subunit 13 2 2
MIRT505903 RIMS3 regulating synaptic membrane exocytosis 3 2 6
MIRT506597 MECP2 methyl-CpG binding protein 2 2 4
MIRT508945 AK4 adenylate kinase 4 2 4
MIRT510650 TMEM167A transmembrane protein 167A 2 4
MIRT512847 A1CF APOBEC1 complementation factor 2 6
MIRT514490 SLPI secretory leukocyte peptidase inhibitor 2 4
MIRT520637 NPM3 nucleophosmin/nucleoplasmin 3 2 6
MIRT528919 TOMM20 translocase of outer mitochondrial membrane 20 2 6
MIRT529866 DGAT1 diacylglycerol O-acyltransferase 1 2 2
MIRT533359 UBE2W ubiquitin conjugating enzyme E2 W 2 2
MIRT534688 RNF125 ring finger protein 125 2 2
MIRT535930 MIER1 MIER1 transcriptional regulator 2 2
MIRT538253 CUL3 cullin 3 2 4
MIRT546021 WDR26 WD repeat domain 26 2 4
MIRT547354 NAT8L N-acetyltransferase 8 like 2 2
MIRT549430 ACVR1 activin A receptor type 1 2 2
MIRT551488 TMEM192 transmembrane protein 192 2 4
MIRT554624 RPS6KA3 ribosomal protein S6 kinase A3 2 2
MIRT560155 MOB1A MOB kinase activator 1A 2 2
MIRT560447 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT560711 ZNF324B zinc finger protein 324B 2 2
MIRT560962 WRN Werner syndrome RecQ like helicase 2 2
MIRT563870 FAM206A family with sequence similarity 206 member A 2 2
MIRT564138 ZNF689 zinc finger protein 689 2 2
MIRT568121 CDC27 cell division cycle 27 2 2
MIRT568141 CCDC88C coiled-coil domain containing 88C 2 2
MIRT568285 BCOR BCL6 corepressor 2 2
MIRT568469 ARMC12 armadillo repeat containing 12 2 2
MIRT569742 GPR173 G protein-coupled receptor 173 2 2
MIRT570175 LIPG lipase G, endothelial type 2 2
MIRT570545 RPH3A rabphilin 3A 2 2
MIRT570952 CPE carboxypeptidase E 2 2
MIRT572800 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT573114 ERBB2IP erbb2 interacting protein 2 2
MIRT574212 SDCBP syndecan binding protein 2 2
MIRT574662 KIF5B kinesin family member 5B 2 2
MIRT662448 SERPINB5 serpin family B member 5 2 2
MIRT695768 C4orf33 chromosome 4 open reading frame 33 2 2
MIRT705832 AIFM2 apoptosis inducing factor, mitochondria associated 2 2 2
MIRT712185 SRSF10 serine and arginine rich splicing factor 10 2 2
MIRT712996 CDV3 CDV3 homolog 2 2
MIRT714411 ZNF706 zinc finger protein 706 2 2
MIRT719226 CAMK4 calcium/calmodulin dependent protein kinase IV 2 2
MIRT720279 EIF1AD eukaryotic translation initiation factor 1A domain containing 2 2
MIRT720946 PPP1R3E protein phosphatase 1 regulatory subunit 3E 2 2
MIRT723201 KLHDC10 kelch domain containing 10 2 2

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