miRTarBase - #MIRT338286


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pre-miRNA Information
pre-miRNA hsa-let-7a-1   
Genomic Coordinates chr9: 94175957 - 94176036
Synonyms LET7A1, MIRNLET7A1, let-7a-1, MIRLET7A1
Description Homo sapiens let-7a-1 stem-loop
Comment let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatible with the genome sequence.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-let-7a-3   
Genomic Coordinates chr22: 46112749 - 46112822
Synonyms LET7A3, MIRNLET7A3, let-7a-3, MIRLET7A3
Description Homo sapiens let-7a-3 stem-loop
Comment let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatible with the genome sequence.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-let-7a-3p
Sequence 57| CUAUACAAUCUACUGUCUUUC |77
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 5 9 + 94176017 29233923 MiREDiBase
A-to-I 5 22 + 46112804 29233923 MiREDiBase
A-to-I 12 22 + 46112811 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs972845958 1 dbSNP
rs781681931 2 dbSNP
rs748585376 3 dbSNP
rs779353569 6 dbSNP
rs1198423693 8 dbSNP
rs970921980 8 dbSNP
rs372596018 9 dbSNP
rs770208205 10 dbSNP
rs1453867589 11 dbSNP
rs1399588338 15 dbSNP
rs1219969167 16 dbSNP
rs1265084977 18 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SYF2   
Synonyms CBPIN, NTC31, P29, fSAP29
Description SYF2 pre-mRNA splicing factor
Transcript NM_015484   
Other Transcripts NM_207170   
Expression
Putative miRNA Targets on SYF2
3'UTR of SYF2
(miRNA target sites are highlighted)		 
>SYF2|NM_015484|3'UTR
   1 TCCCTTCAAGAACTGTTTATAGAAGCTTGAGAATGGGGTAAAAATTTCTGCTAGCAAAATCAAGTTCTTTTTGAAATTTT
  81 ATCAGTAATCCAGAATTTAGTAGTCCATGCCTTCTCACTCAGCATTTAGAAATAAAAATGTGGTTTCTTAAACGTATATC
 161 CTTTCATGTATATTTCCACATTTTTGTGCTTGGATATAAGATGTATTTCTTGTAGTGAAGTTGTTTTGTAATCTACTTTG
 241 TATACATTCTAATTATATTATTTTTCTATGTATTTTAAATGTATATGGCTGTTTAATCTTTGAAGCATTTTGGGCTTAAG
 321 ATTGCCAGCAGCACACATCAGATGCAGTCATTGTTGCTATCAGTGTGGAATTTGATAGAGTCTAGACTCGGGCCACTTGG
 401 AGTTGTGTACTCCAAAGCTAAGGACAGTGATGAGGAAGATGGCAGTGGCCACCGGAGGACTGGAGCAGTCCCTCCTCATG
 481 GCGGCCTGTGACCAAGGTCGGGGAGGAGTGGAGCTATCCTTCCATGATCTGATCATGTACAGTTCCCTTTTTAAAAAGCA
 561 ATAAATGCTTGGGATTAGAATTTCTAACATTTTTAGTCTATCATTTAAAACAAACATTTGTATATATACATTTGTTTATA
 641 TACATACATGCTTCCATTCTACAAACACTGAAAGAATATTTTATTATGGGAAATTCCATACACCCAATACCCCTGGTGAG
 721 TCCCATATACCCAGTACCCTGTTCAACAATCATTAACTCATGGCCAGTCCTGCTTCATCTTTATTTCCATTTACTTTCTT
 801 CATGACTCTTATTTTGACGCATATACTAGATATATAATTTCATCTATAATTATTTTAGTATGTATCTCTGAAAGATAAAG
 881 ACTTAAATGACCACAATACTATTATCACTGCAATAGATTTATTTTTATAAAACTCCAGAGGGAAAGGTTGTTATTTTTTC
 961 TCTATGTTGAATTAAATGCTAAATATCTAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuUUCUGU-CAUCU-AACAUAUc 5'
            ::| ||  |:|| ||||:|| 
Target 5' tcGGGCCACTTGGAGTTGTGTAc 3'
 388 - 410 135.00 -7.40
2 
miRNA  3' cuUUCUGUCAU--CUAACAUauc 5'
            ||||: |||    |||||   
Target 5' atAAGAT-GTATTTCTTGTAgtg 3'
 196 - 217 112.00 -5.50
3 
miRNA  3' cuuUCUGUC-AUCUAAC-AUAuc 5'
             ||| :|  ||:||| |||  
Target 5' tccAGAGGGAAAGGTTGTTATtt 3'
 934 - 956 106.00 -9.99
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN15626578 2 COSMIC
COSN26997592 10 COSMIC
COSN19735053 67 COSMIC
COSN31525458 75 COSMIC
COSN31614382 96 COSMIC
COSN30129374 98 COSMIC
COSN31500655 114 COSMIC
COSN1101939 156 COSMIC
COSN31580464 209 COSMIC
COSN14984183 471 COSMIC
COSN16236008 540 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1229393741 2 dbSNP
rs199685299 7 dbSNP
rs1318253781 8 dbSNP
rs1398445797 9 dbSNP
rs200205670 11 dbSNP
rs1173843821 18 dbSNP
rs1045554 20 dbSNP
rs754600999 23 dbSNP
rs1190205868 30 dbSNP
rs1449856858 35 dbSNP
rs751159633 36 dbSNP
rs765941929 38 dbSNP
rs757874462 42 dbSNP
rs1262297691 83 dbSNP
rs754962494 86 dbSNP
rs1346840811 91 dbSNP
rs1278003454 96 dbSNP
rs1241085825 101 dbSNP
rs1017074148 112 dbSNP
rs1005313398 116 dbSNP
rs1463524027 117 dbSNP
rs759496836 122 dbSNP
rs960172609 124 dbSNP
rs577339625 125 dbSNP
rs754390370 127 dbSNP
rs1434383124 143 dbSNP
rs1286187053 144 dbSNP
rs1454698542 154 dbSNP
rs1242613798 156 dbSNP
rs1157670799 160 dbSNP
rs9899 161 dbSNP
rs554018713 166 dbSNP
rs534193476 168 dbSNP
rs1319122990 186 dbSNP
rs201219608 194 dbSNP
rs1485173099 198 dbSNP
rs905042422 201 dbSNP
rs1255067938 206 dbSNP
rs1243483611 213 dbSNP
rs766838098 217 dbSNP
rs1206680768 227 dbSNP
rs895759667 228 dbSNP
rs761091332 235 dbSNP
rs1236856841 243 dbSNP
rs1337006329 257 dbSNP
rs1294055899 262 dbSNP
rs937217395 268 dbSNP
rs904369353 270 dbSNP
rs1462309225 277 dbSNP
rs1042838727 279 dbSNP
rs946835812 298 dbSNP
rs190071310 302 dbSNP
rs1415431327 305 dbSNP
rs1161132333 306 dbSNP
rs913952686 312 dbSNP
rs1474639030 315 dbSNP
rs1415253695 324 dbSNP
rs1023468881 329 dbSNP
rs1195003168 339 dbSNP
rs111773680 351 dbSNP
rs186257993 359 dbSNP
rs1203313697 360 dbSNP
rs1010842004 363 dbSNP
rs554701260 365 dbSNP
rs933972514 372 dbSNP
rs1332886029 378 dbSNP
rs893434662 380 dbSNP
rs1280001842 388 dbSNP
rs377636381 389 dbSNP
rs376004646 390 dbSNP
rs1326204080 391 dbSNP
rs1316753112 392 dbSNP
rs922917533 407 dbSNP
rs112748734 412 dbSNP
rs1325949239 418 dbSNP
rs1460486503 423 dbSNP
rs964254362 426 dbSNP
rs867437039 435 dbSNP
rs1475578342 443 dbSNP
rs149612671 453 dbSNP
rs951184109 454 dbSNP
rs1455500379 461 dbSNP
rs1214027116 478 dbSNP
rs750769699 482 dbSNP
rs1467166322 483 dbSNP
rs1041228440 484 dbSNP
rs1025800908 485 dbSNP
rs1013953830 486 dbSNP
rs1268718679 490 dbSNP
rs959973535 491 dbSNP
rs1208266198 492 dbSNP
rs1355963127 495 dbSNP
rs1033939774 500 dbSNP
rs942814404 506 dbSNP
rs1298418680 515 dbSNP
rs1439394904 524 dbSNP
rs1347611614 534 dbSNP
rs767809022 536 dbSNP
rs532380406 538 dbSNP
rs138225984 545 dbSNP
rs1395361764 545 dbSNP
rs546934162 547 dbSNP
rs781202216 559 dbSNP
rs1297521353 562 dbSNP
rs1442052305 573 dbSNP
rs3179809 585 dbSNP
rs1010466899 587 dbSNP
rs931608409 600 dbSNP
rs774969539 601 dbSNP
rs182984540 610 dbSNP
rs934052044 611 dbSNP
rs1352011460 622 dbSNP
rs918562284 624 dbSNP
rs1437422619 630 dbSNP
rs769370561 638 dbSNP
rs1213353052 640 dbSNP
rs1404358594 663 dbSNP
rs1396848466 664 dbSNP
rs1039697503 666 dbSNP
rs1169920730 680 dbSNP
rs571307560 695 dbSNP
rs1389406336 697 dbSNP
rs942948400 698 dbSNP
rs928684560 707 dbSNP
rs758950040 710 dbSNP
rs984331779 711 dbSNP
rs1244733396 712 dbSNP
rs1172796145 725 dbSNP
rs1412619015 731 dbSNP
rs969166243 732 dbSNP
rs1451240580 742 dbSNP
rs1023442852 746 dbSNP
rs918384864 748 dbSNP
rs992993026 749 dbSNP
rs959784084 750 dbSNP
rs1486156653 752 dbSNP
rs1033992000 760 dbSNP
rs1011221489 765 dbSNP
rs1319197519 774 dbSNP
rs1001134201 789 dbSNP
rs968630766 798 dbSNP
rs377160800 818 dbSNP
rs190641564 819 dbSNP
rs1010104624 821 dbSNP
rs1355703051 823 dbSNP
rs1312003047 829 dbSNP
rs1031075265 833 dbSNP
rs1346798234 844 dbSNP
rs891626007 846 dbSNP
rs1370406792 853 dbSNP
rs999237738 855 dbSNP
rs1051572415 859 dbSNP
rs1273434990 868 dbSNP
rs998689330 873 dbSNP
rs1475622351 874 dbSNP
rs1417456800 877 dbSNP
rs770990526 885 dbSNP
rs1039748834 889 dbSNP
rs751872465 891 dbSNP
rs1215684712 899 dbSNP
rs900839750 901 dbSNP
rs910167801 913 dbSNP
rs1309479924 928 dbSNP
rs1427217012 935 dbSNP
rs1292271595 936 dbSNP
rs1049117608 941 dbSNP
rs1363813239 953 dbSNP
rs930207040 954 dbSNP
rs1040780260 962 dbSNP
rs1386370615 969 dbSNP
rs1327965549 978 dbSNP
rs918761612 979 dbSNP
rs1393882779 980 dbSNP
rs1162939102 983 dbSNP
rs992984083 988 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 25949.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
CLIP-seq Support 1 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000236273.4 | 3UTR | UAUACAUUCUAAUUAUAUUAUUUUUCUAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
ESCA 0.68 0.01 0.691 0.01 11 Click to see details
KICH 0.313 0.06 0.227 0.14 25 Click to see details
HNSC -0.199 0.1 -0.096 0.27 42 Click to see details
LUAD 0.385 0.11 0.357 0.13 12 Click to see details
LIHC -0.175 0.11 -0.101 0.24 49 Click to see details
PRAD -0.168 0.12 -0.187 0.1 50 Click to see details
KIRC 0.126 0.15 0.047 0.35 68 Click to see details
COAD -0.592 0.2 -1.000 0.5 4 Click to see details
KIRP -0.135 0.23 -0.097 0.3 32 Click to see details
BLCA 0.172 0.25 0.003 0.5 18 Click to see details
PAAD 0.453 0.27 0.400 0.3 4 Click to see details
CHOL 0.164 0.34 0.067 0.43 9 Click to see details
LUSC 0.059 0.36 0.131 0.22 38 Click to see details
UCEC -0.083 0.37 0.047 0.42 19 Click to see details
THCA -0.034 0.4 -0.090 0.25 59 Click to see details
CESC -0.273 0.41 -0.500 0.33 3 Click to see details
STAD -0.012 0.47 -0.082 0.33 32 Click to see details
PCPG 0.06 0.48 0.500 0.33 3 Click to see details
BRCA 0.001 0.5 -0.004 0.49 84 Click to see details
BRCA 0.001 0.5 -0.004 0.49 84 Click to see details
121 hsa-let-7a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT038998 ARMC8 armadillo repeat containing 8 1 1
MIRT038999 SETD4 SET domain containing 4 1 1
MIRT039000 BTF3 basic transcription factor 3 1 1
MIRT039001 MIPOL1 mirror-image polydactyly 1 1 1
MIRT039002 TRIM33 tripartite motif containing 33 1 1
MIRT039003 CS citrate synthase 1 1
MIRT039004 SENP7 SUMO1/sentrin specific peptidase 7 1 1
MIRT055418 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 10
MIRT057681 LCOR ligand dependent nuclear receptor corepressor 2 8
MIRT061351 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT062174 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT071813 RNF11 ring finger protein 11 2 2
MIRT091374 EIF4A2 eukaryotic translation initiation factor 4A2 2 2
MIRT095107 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT098814 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT109534 KLHL15 kelch like family member 15 2 4
MIRT120263 GSK3B glycogen synthase kinase 3 beta 2 2
MIRT149839 LDLR low density lipoprotein receptor 2 6
MIRT164519 MSMO1 methylsterol monooxygenase 1 2 2
MIRT165879 CREBRF CREB3 regulatory factor 2 2
MIRT169899 HBP1 HMG-box transcription factor 1 2 4
MIRT182779 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT193466 RORA RAR related orphan receptor A 2 2
MIRT226421 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 2
MIRT334410 CREBZF CREB/ATF bZIP transcription factor 2 6
MIRT338286 SYF2 SYF2 pre-mRNA splicing factor 2 2
MIRT361627 TES testin LIM domain protein 2 2
MIRT406687 ZNF181 zinc finger protein 181 2 2
MIRT407768 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT449468 HAT1 histone acetyltransferase 1 2 2
MIRT467110 SRI sorcin 2 2
MIRT475099 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 6
MIRT481671 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT493061 MTFR1 mitochondrial fission regulator 1 2 2
MIRT497923 BTG1 BTG anti-proliferation factor 1 2 2
MIRT498202 ACVR2B activin A receptor type 2B 2 2
MIRT503391 ASB11 ankyrin repeat and SOCS box containing 11 2 6
MIRT503862 UBXN2B UBX domain protein 2B 2 2
MIRT504368 ARID1B AT-rich interaction domain 1B 2 4
MIRT504991 ZNF652 zinc finger protein 652 2 2
MIRT505754 SENP1 SUMO1/sentrin specific peptidase 1 2 8
MIRT518102 ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2 6
MIRT521930 PHF8 PHD finger protein 8 2 4
MIRT522139 NRBF2 nuclear receptor binding factor 2 2 6
MIRT522401 MYADM myeloid associated differentiation marker 2 4
MIRT523593 FZD5 frizzled class receptor 5 2 4
MIRT523944 E2F8 E2F transcription factor 8 2 4
MIRT524355 CREB1 cAMP responsive element binding protein 1 2 2
MIRT525140 ZNF256 zinc finger protein 256 2 2
MIRT527070 ABCC4 ATP binding cassette subfamily C member 4 2 2
MIRT527486 OCIAD1 OCIA domain containing 1 2 2
MIRT528129 PPP1R10 protein phosphatase 1 regulatory subunit 10 2 2
MIRT530528 ALG10B ALG10B, alpha-1,2-glucosyltransferase 2 2
MIRT531270 PPIL3 peptidylprolyl isomerase like 3 2 2
MIRT538898 BRI3BP BRI3 binding protein 2 2
MIRT541371 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT541526 MGAT4C MGAT4 family member C 2 2
MIRT543776 RBM12B RNA binding motif protein 12B 2 4
MIRT543946 NCOA7 nuclear receptor coactivator 7 2 2
MIRT545156 GABRG1 gamma-aminobutyric acid type A receptor gamma1 subunit 2 2
MIRT545848 ZNF264 zinc finger protein 264 2 4
MIRT546064 VEZF1 vascular endothelial zinc finger 1 2 2
MIRT546481 SLC16A14 solute carrier family 16 member 14 2 4
MIRT551835 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT551901 ACP1 acid phosphatase 1, soluble 2 2
MIRT552490 ZNF136 zinc finger protein 136 2 2
MIRT554206 SLC35A5 solute carrier family 35 member A5 2 2
MIRT554295 SIPA1L2 signal induced proliferation associated 1 like 2 2 2
MIRT555765 PCTP phosphatidylcholine transfer protein 2 2
MIRT558315 DSG2 desmoglein 2 2 2
MIRT563147 NOLC1 nucleolar and coiled-body phosphoprotein 1 2 2
MIRT566464 PGGT1B protein geranylgeranyltransferase type I subunit beta 2 2
MIRT567322 HMGB2 high mobility group box 2 2 2
MIRT567738 DLX2 distal-less homeobox 2 2 2
MIRT567892 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT570087 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 2
MIRT571136 TTC33 tetratricopeptide repeat domain 33 2 2
MIRT573534 MDM2 MDM2 proto-oncogene 2 2
MIRT574465 RPS16 ribosomal protein S16 2 2
MIRT574998 Phka1 phosphorylase kinase alpha 1 2 3
MIRT610202 CD99 CD99 molecule (Xg blood group) 2 4
MIRT612926 GPRIN3 GPRIN family member 3 2 2
MIRT615027 DUSP6 dual specificity phosphatase 6 2 2
MIRT617200 GREM1 gremlin 1, DAN family BMP antagonist 2 2
MIRT628720 ZNF585A zinc finger protein 585A 2 2
MIRT641491 POLA2 DNA polymerase alpha 2, accessory subunit 2 2
MIRT641663 PAPOLG poly(A) polymerase gamma 2 2
MIRT642216 RUVBL2 RuvB like AAA ATPase 2 2 2
MIRT654589 PURA purine rich element binding protein A 2 2
MIRT656136 MSH6 mutS homolog 6 2 2
MIRT656899 KIAA2018 upstream transcription factor family member 3 2 2
MIRT660136 BRPF3 bromodomain and PHD finger containing 3 2 2
MIRT660861 AFAP1 actin filament associated protein 1 2 2
MIRT676849 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 3
MIRT681479 DIP2A disco interacting protein 2 homolog A 2 2
MIRT682259 RS1 retinoschisin 1 2 2
MIRT685602 MYOM2 myomesin 2 2 2
MIRT686943 SFT2D3 SFT2 domain containing 3 2 2
MIRT694302 COPB2 coatomer protein complex subunit beta 2 2 2
MIRT694407 ALDH1A3 aldehyde dehydrogenase 1 family member A3 2 2
MIRT697280 ZNF800 zinc finger protein 800 2 2
MIRT698414 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT698989 SPAG9 sperm associated antigen 9 2 2
MIRT699766 SEMA4D semaphorin 4D 2 2
MIRT699928 RUFY2 RUN and FYVE domain containing 2 2 2
MIRT702113 MBNL1 muscleblind like splicing regulator 1 2 2
MIRT702373 KLF10 Kruppel like factor 10 2 2
MIRT702646 ITGA3 integrin subunit alpha 3 2 2
MIRT705713 ANAPC16 anaphase promoting complex subunit 16 2 2
MIRT717925 ZNF546 zinc finger protein 546 2 2
MIRT720839 C1orf52 chromosome 1 open reading frame 52 2 2
MIRT725033 NDUFAF7 NADH:ubiquinone oxidoreductase complex assembly factor 7 2 2
MIRT731448 APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A 1 1
MIRT733217 CCNG1 cyclin G1 2 0
MIRT734887 LIN28B lin-28 homolog B 1 0
MIRT735276 HMGA2 high mobility group AT-hook 2 2 0
MIRT735727 SYNCRIP synaptotagmin binding cytoplasmic RNA interacting protein 3 0
MIRT736087 RCVRN recoverin 1 0
MIRT736088 RHO rhodopsin 1 0
MIRT736103 TLR7 toll like receptor 7 1 0
MIRT736607 TPO thyroid peroxidase 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
let-7a Caudatin NULL 21633059 Quantitative real-time PCR gastric carcinoma cell lines 23708208 2013 up-regualted
let-7a XMD8-92 NULL 46843772 Microarray pancreatic ductal adenocarcinoma cell 24880079 2014 up-regulated
let-7a Hydroxamic acid HDACi LAQ824 NULL NULL Microarray breast cancer cell line SKBr3 16452179 2006 down-regulated
let-7a Hydroxamic acid HDACi LAQ824 NULL NULL Northern blot breast cancer cell line SKBr3 16452180 2006 down-regulated
let-7a Trichostatin A (TSA) NULL 444732 Microarray human pancreatic cancer cell line BxPC-3 19112422 2009 down-regulated
let-7a 17beta-estradiol (E2) approved 5757 Microarray MCF-7 breast cancer cells 19528081 2009 up-regulated
let-7a Etoposide approved 36462 Microarray Normal human fibroblasts (AG01522) 19633716 2009 down-regulated
let-7a Etoposide approved 36462 Quantitative real-time PCR Normal human fibroblasts (AG01522) 19633716 2009 down-regulated
let-7a Polylysine NULL 162282 Quantitative real-time PCR 293T(FLAG AGO2) cells 20529860 2010 down-regulated
let-7a Trypaflavine NULL NULL Quantitative real-time PCR 293T(FLAG AGO2) cells 20529860 2010 down-regulated
let-7a Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
let-7a Enoxacin approved 3229 Northern blot HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
let-7a Enoxacin approved 3229 Quantitative real-time PCR HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
let-7a Metformin approved 4091 Quantitative real-time PCR MCF-7 human mammary cancer cell line 21368581 2011 up-regulated
let-7a 5-Fluorouracil approved 3385 Microarray MCF-7 breast cancer cells 21506117 2011 up-regulated
let-7a Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
let-7a Metformin approved 4091 Quantitative real-time PCR pancreatic cancer cells 22086681 2012 up-regulated
let-7a Metformin approved 4091 Quantitative real-time PCR pancreatic cancer cells 22086681 2012 up-regulated
let-7a CDF(analogues of curcumin) NULL NULL Quantitative real-time PCR pancreatic cancer cells 22108826 2012 up-regulated
let-7a Marine fungal metabolite 1386A NULL NULL Microarray MCF-7 breast cancer cells. 22159329 2012 down-regulated
let-7a Curcumin NULL 969516 Quantitative real-time PCR esophageal cancer cells 22363450 2012 up-regulated
let-7a 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 up-regulated
let-7a Vitamin D3 approved 5280795 Quantitative real-time PCR Plasma 22594500 2012 up-regulated
let-7a Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse liver 19270793 2009 down-regulated
let-7a Budesonide approved 5281004 Microarray neonatal mice liver 20145010 2010 up-regulated
let-7a Budesonide approved 5281004 Microarray neonatal mice lung 20145010 2010 down-regulated
let-7a Phenethyl isothiocyanate(PEITC) NULL 16741 Microarray neonatal mice lung 20145010 2010 up-regulated
let-7a Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 down-regulated
let-7a Dexamethasone approved 5743 Quantitative real-time PCR primary rat thymocytes 20847043 2010 down-regulated
let-7a Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
let-7a Hydroxychloroquine approved 3652 Quantitative real-time PCR mesangial cells 24121037 2013 down-regualted
let-7a Prednisone approved 5865 Quantitative real-time PCR mesangial cells 24121037 2013 down-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-let-7a-3p Gemcitabine 60750 NSC613327 approved resistant High Cholangiocarcinoma cell line (HuCCT1, HuH28)
hsa-let-7a-3p Docetaxel 148124 NSC628503 approved sensitive High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-let-7a-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-let-7a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-let-7a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-let-7a-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-let-7a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-let-7a-3p Fluorouracil 3385 NSC19893 approved sensitive cell line (HCT15)
hsa-let-7a-3p 4-Hydroxytamoxifen+Tamoxifen resistant cell line (LY2)
hsa-let-7a-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-let-7a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-let-7a-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-let-7a-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide sensitive cell line (Bads-200)

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