miRTarBase - #MIRT338925


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pre-miRNA Information
pre-miRNA hsa-mir-5703   
Genomic Coordinates chr2: 227472132 - 227472187
Description Homo sapiens miR-5703 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-5703
Sequence 31| AGGAGAAGUCGGGAAGGU |48
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1183679532 2 dbSNP
rs932217747 3 dbSNP
rs1209011098 5 dbSNP
rs1486736741 8 dbSNP
rs1051940023 9 dbSNP
rs1223246998 10 dbSNP
rs1232901648 11 dbSNP
rs1424402647 12 dbSNP
rs890720113 15 dbSNP
rs1350946664 17 dbSNP
rs1292388472 18 dbSNP
rs1399653485 18 dbSNP
rs752410442 18 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol HMGN2   
Synonyms HMG17
Description high mobility group nucleosomal binding domain 2
Transcript NM_005517   
Expression
Putative miRNA Targets on HMGN2
3'UTR of HMGN2
(miRNA target sites are highlighted)		 
>HMGN2|NM_005517|3'UTR
   1 AGTGTGTGCATTTTTGATAACTGTGTACTTCTGGTGACTGTACAGTTTGAAATACTATTTTTTATCAAGTTTTATAAAAA
  81 TGCAGAATTTTGTTTTACTTTTTTTTTTTTTTTAAAAGCTATGTTGTTAGCACACAGAACACTTCATTGTTGTTTTTGGG
 161 GGAAGGGGCATATGTCACTAATAGAATGTCTCCAAAGCTGGATTGATGTGGAGAAAACACCTTTCCCTTCTAGTTTTGAG
 241 AGACTTCCTCTTGGCTCCCAGGAGGAGGGATTCCCTGACTTTGACACACATGGCCACCTTGGCACAAAAGCCTTGTGGTA
 321 TAGAAAAACAAATTTGTTTTTATGTCCTCTTCTCCCTTTCCATCGTTCAGCATAGACTTAACTCCCTTAAGCCCAGACAT
 401 CTGTTGAGACCTGACCCCTAGTCATTGGTTACCAGTGTGTCAGGCAATCTGGACTTTCCAGTGATGCCACTGAGATGGCA
 481 CCTGTCAAAAGAGCAGTGGTTCCATTTCTAGATTGTGGATCTTCAGATAAATTCTGCCATTTTCATTTCACTTCCTGAAA
 561 GTCAGGGTCGGCTTGTGAAAAGTTGTTAAACAACATGCTAAATGTGAAATGTCAACCCTCACTCTAAACTTTCCCTGTTC
 641 AGAGCATCAGATGAAGACTTCATTGGGTTTTATAGTGGCTTTCTGATTTTTGGTAGTCCATTGAAGAAGGGAGTTTGAAA
 721 GTTGTTGTATACTGTTAACGATTGTCTGCCCATGTCCTGCCTGAAATACCATGATTGTTTATGGAAAGTATCTTTAATAA
 801 AGCTGGATACAGTTTGGCTTGGAATGCTGCCTCTGATCTTTTCCCACAAGTGGGGTAACCTGGTTTATCCAAGTCTCTTG
 881 GAACAGGGTACGTTCTGCTTTGAGGTACTCCATGTACAGTCTAATGATGATCTTTCACTGATTTATAGTCAGCTTCCAAA
 961 ACACACAGTGCTAGGTGCAGTTAGGAAGGATTCCAGGAGTAGACTTAGCTGATGGTGAAAGGCTGGGAGTATGGAGTGAT
1041 TTCTGTACTTGGTTATGCAGCATTCCCTGCAGTGTTTGTTTTTTGCATGACTCCGAATACATGAAGTGTATTAAATGCAG
1121 ATTTTTGGTAGATCTGCGGTTTTGGCTGGGTAGCTGACAGGAGCCTCTCTACTTCCATCTGCATTTGCAACTTCTATAAA
1201 ATTAGCAAATTAATAGACTCATGTCAGAGAGTGTCTCTGTGAATGTGTACACAGTTGTCCATTTGTAAGGTAGATGACAC
1281 TTTGCTCCTAAGTAGACCTGCAAACAAAGACAATGGGGTCTTTCCTGATTCCTTTAGTTTGGAGATGCAGAGAACCCCAC
1361 GTTTCTCTAAGTGAAATGGCAAGAAGTTATTTGTTAGAATATGGAACTGGTAACAAATTCATGTTTGCACCTTGAATTTG
1441 CTTTCACAGACCTGGCTGTATTGTTGGACAGGAATAAAGTAAATTGGAGACTAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uggaAGGGCUGAAGAGGa 5'
              |||:  ||||||| 
Target 5' tatgTCCT--CTTCTCCc 3'
 341 - 356 146.00 -12.70
2 
miRNA  3' ugGAAG--GGCU-GAAGAGGa 5'
            || |  |:|| |||:||| 
Target 5' tgCTGCCTCTGATCTTTTCCc 3'
 825 - 845 134.00 -14.20
3 
miRNA  3' ugGAAGGGCUGAAGAgga 5'
            |||:||  |||||   
Target 5' acCTTTCC--CTTCTagt 3'
 219 - 234 116.00 -13.62
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN26979036 13 COSMIC
COSN30151377 20 COSMIC
COSN19750558 40 COSMIC
COSN30158852 50 COSMIC
COSN30104860 60 COSMIC
COSN24388781 74 COSMIC
COSN19626978 98 COSMIC
COSN31611530 110 COSMIC
COSN31558162 111 COSMIC
COSN30497873 113 COSMIC
COSN20094603 114 COSMIC
COSN27256768 114 COSMIC
COSN508652 114 COSMIC
COSN16129141 115 COSMIC
COSN19617216 124 COSMIC
COSN30176661 138 COSMIC
COSN15094563 366 COSMIC
COSN28553667 555 COSMIC
COSN28554567 570 COSMIC
COSN8638080 610 COSMIC
COSN8638081 629 COSMIC
COSN30161189 799 COSMIC
COSN27719401 811 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1301111355 2 dbSNP
rs1378570125 3 dbSNP
rs1304998732 5 dbSNP
rs754337865 9 dbSNP
rs1320879354 10 dbSNP
rs1044066319 11 dbSNP
rs1295404148 17 dbSNP
rs1316436339 20 dbSNP
rs757341291 22 dbSNP
rs758764308 22 dbSNP
rs1484506678 23 dbSNP
rs905556299 24 dbSNP
rs1203788955 25 dbSNP
rs1261410880 27 dbSNP
rs1488748904 28 dbSNP
rs779149059 28 dbSNP
rs541096854 29 dbSNP
rs1309719439 30 dbSNP
rs758726603 34 dbSNP
rs1254865828 40 dbSNP
rs780379104 43 dbSNP
rs747946314 45 dbSNP
rs1260672989 46 dbSNP
rs1267037562 49 dbSNP
rs1319046026 52 dbSNP
rs1337749940 58 dbSNP
rs563970937 58 dbSNP
rs1237324225 67 dbSNP
rs11554702 70 dbSNP
rs1258663803 77 dbSNP
rs1352492433 92 dbSNP
rs931778403 95 dbSNP
rs983965803 98 dbSNP
rs1050591642 99 dbSNP
rs1190478827 99 dbSNP
rs1250985680 99 dbSNP
rs369602798 99 dbSNP
rs1375153062 100 dbSNP
rs1156662639 101 dbSNP
rs376412562 103 dbSNP
rs1008688731 104 dbSNP
rs1310247004 107 dbSNP
rs1020041501 110 dbSNP
rs1299303489 114 dbSNP
rs1457854165 114 dbSNP
rs549673440 114 dbSNP
rs769935209 115 dbSNP
rs1231121254 116 dbSNP
rs1390072922 117 dbSNP
rs1257887828 120 dbSNP
rs1000046440 122 dbSNP
rs199694531 124 dbSNP
rs1246202604 125 dbSNP
rs1293323584 127 dbSNP
rs9725396 130 dbSNP
rs1236066190 132 dbSNP
rs879824896 134 dbSNP
rs1251885844 136 dbSNP
rs994055172 138 dbSNP
rs1179089842 140 dbSNP
rs1251950996 141 dbSNP
rs1026896778 143 dbSNP
rs1177542748 144 dbSNP
rs1180042491 148 dbSNP
rs563195125 158 dbSNP
rs1466943182 159 dbSNP
rs1175313095 162 dbSNP
rs796717888 166 dbSNP
rs1167857234 168 dbSNP
rs1237300458 170 dbSNP
rs1398813871 175 dbSNP
rs1449462647 176 dbSNP
rs529075985 185 dbSNP
rs548732932 188 dbSNP
rs1385335546 193 dbSNP
rs1303452883 194 dbSNP
rs965413947 194 dbSNP
rs9328729 198 dbSNP
rs565853713 210 dbSNP
rs796819358 213 dbSNP
rs796147835 215 dbSNP
rs1423390525 222 dbSNP
rs970765686 226 dbSNP
rs534836127 227 dbSNP
rs1460877701 231 dbSNP
rs9328730 232 dbSNP
rs908017312 233 dbSNP
rs1407208253 235 dbSNP
rs1452930884 236 dbSNP
rs796736102 243 dbSNP
rs1316781766 248 dbSNP
rs1319962987 255 dbSNP
rs1376510793 259 dbSNP
rs1199013576 260 dbSNP
rs1295647333 268 dbSNP
rs1031123655 272 dbSNP
rs9328731 276 dbSNP
rs957082204 281 dbSNP
rs962311041 282 dbSNP
rs1205327601 287 dbSNP
rs1241579158 290 dbSNP
rs1192573233 291 dbSNP
rs796900443 292 dbSNP
rs1427395017 296 dbSNP
rs1190483370 297 dbSNP
rs796524834 298 dbSNP
rs1467689614 299 dbSNP
rs796567144 302 dbSNP
rs1430588958 303 dbSNP
rs879483614 315 dbSNP
rs879910315 316 dbSNP
rs1471197587 317 dbSNP
rs9729961 319 dbSNP
rs1335103295 320 dbSNP
rs1357115782 321 dbSNP
rs9725728 323 dbSNP
rs920307725 332 dbSNP
rs1159676844 335 dbSNP
rs1368649819 336 dbSNP
rs1288946788 337 dbSNP
rs1381682374 341 dbSNP
rs1363379330 343 dbSNP
rs373314466 347 dbSNP
rs989638500 349 dbSNP
rs1219204135 354 dbSNP
rs1272238431 355 dbSNP
rs1324149172 357 dbSNP
rs1050055294 361 dbSNP
rs1276189030 363 dbSNP
rs7551199 366 dbSNP
rs1243927314 368 dbSNP
rs1484965965 371 dbSNP
rs1223567671 373 dbSNP
rs1265658351 376 dbSNP
rs1485363828 381 dbSNP
rs1481691562 382 dbSNP
rs1174755478 383 dbSNP
rs944431869 385 dbSNP
rs915477475 387 dbSNP
rs948284711 392 dbSNP
rs1264735305 396 dbSNP
rs903007948 399 dbSNP
rs1000099764 400 dbSNP
rs981005225 401 dbSNP
rs1195044210 408 dbSNP
rs1297021040 409 dbSNP
rs926918448 411 dbSNP
rs1272869088 412 dbSNP
rs1012667040 415 dbSNP
rs938364040 417 dbSNP
rs1057281191 418 dbSNP
rs1167396547 420 dbSNP
rs1350660118 422 dbSNP
rs537404685 424 dbSNP
rs557693536 434 dbSNP
rs574346258 440 dbSNP
rs1197824122 442 dbSNP
rs918377007 454 dbSNP
rs1470756408 458 dbSNP
rs929780156 458 dbSNP
rs536928022 459 dbSNP
rs962195180 461 dbSNP
rs888292094 462 dbSNP
rs1157565306 468 dbSNP
rs1376971420 469 dbSNP
rs1365591978 472 dbSNP
rs1006777596 473 dbSNP
rs973719817 475 dbSNP
rs1321568535 482 dbSNP
rs9725160 483 dbSNP
rs1330443970 485 dbSNP
rs1442707028 487 dbSNP
rs1313225545 491 dbSNP
rs1315911806 492 dbSNP
rs1281048659 503 dbSNP
rs1374980240 516 dbSNP
rs1239644116 522 dbSNP
rs1039643593 523 dbSNP
rs553316119 527 dbSNP
rs1361756999 533 dbSNP
rs1172940945 541 dbSNP
rs1237551698 545 dbSNP
rs9725753 546 dbSNP
rs796828710 555 dbSNP
rs998228760 558 dbSNP
rs573381052 564 dbSNP
rs986214653 566 dbSNP
rs1237411371 568 dbSNP
rs4104981 570 dbSNP
rs911535928 571 dbSNP
rs1385453914 575 dbSNP
rs1445997070 577 dbSNP
rs944484156 582 dbSNP
rs1010966955 584 dbSNP
rs1389983991 588 dbSNP
rs1022392791 589 dbSNP
rs1415015365 591 dbSNP
rs1330672627 594 dbSNP
rs796622741 597 dbSNP
rs1397766083 604 dbSNP
rs796250446 610 dbSNP
rs1316078139 615 dbSNP
rs1385225783 616 dbSNP
rs1242766681 618 dbSNP
rs1382459238 621 dbSNP
rs1283626978 623 dbSNP
rs924483218 626 dbSNP
rs9725763 627 dbSNP
rs879837358 629 dbSNP
rs1256578921 630 dbSNP
rs1333638582 633 dbSNP
rs1204702137 634 dbSNP
rs935833339 635 dbSNP
rs1054257872 641 dbSNP
rs9659895 648 dbSNP
rs1450154536 651 dbSNP
rs1169519437 652 dbSNP
rs1421385613 655 dbSNP
rs894394558 659 dbSNP
rs866001403 662 dbSNP
rs1372354304 663 dbSNP
rs540807280 667 dbSNP
rs1045112768 668 dbSNP
rs1327043702 668 dbSNP
rs906518124 672 dbSNP
rs1310986591 679 dbSNP
rs928277960 680 dbSNP
rs1232894030 685 dbSNP
rs1275917552 686 dbSNP
rs959966869 688 dbSNP
rs1224558599 693 dbSNP
rs35661952 698 dbSNP
rs1265329847 699 dbSNP
rs992535595 701 dbSNP
rs1198305496 703 dbSNP
rs962081797 704 dbSNP
rs9659627 705 dbSNP
rs1457586939 711 dbSNP
rs1177204605 714 dbSNP
rs918264881 715 dbSNP
rs1240258862 721 dbSNP
rs1195174173 724 dbSNP
rs1261004780 725 dbSNP
rs1440611794 725 dbSNP
rs1172011783 728 dbSNP
rs1423157142 732 dbSNP
rs1416058480 733 dbSNP
rs929682457 733 dbSNP
rs1176934226 734 dbSNP
rs564166439 735 dbSNP
rs909677225 740 dbSNP
rs942548243 741 dbSNP
rs1040017263 745 dbSNP
rs1384031124 747 dbSNP
rs1377113553 752 dbSNP
rs901116156 752 dbSNP
rs9659913 754 dbSNP
rs577221426 755 dbSNP
rs1340471906 767 dbSNP
rs1369135439 774 dbSNP
rs1219358450 776 dbSNP
rs1279917536 789 dbSNP
rs1285587488 791 dbSNP
rs542985227 793 dbSNP
rs1310750706 804 dbSNP
rs1232970693 805 dbSNP
rs1255092202 811 dbSNP
rs1350915977 812 dbSNP
rs1052425704 813 dbSNP
rs563257307 819 dbSNP
rs17340420 827 dbSNP
rs1487925880 836 dbSNP
rs1199991709 837 dbSNP
rs1269364739 839 dbSNP
rs370525094 844 dbSNP
rs1010913115 847 dbSNP
rs1197858645 848 dbSNP
rs1364645789 852 dbSNP
rs1022340376 853 dbSNP
rs1387567507 856 dbSNP
rs986381455 859 dbSNP
rs969526768 860 dbSNP
rs185570488 865 dbSNP
rs1425857774 867 dbSNP
rs1295860847 871 dbSNP
rs965676651 880 dbSNP
rs1198460247 881 dbSNP
rs1241787317 885 dbSNP
rs977182516 885 dbSNP
rs1245003486 891 dbSNP
rs138674443 892 dbSNP
rs960964375 893 dbSNP
rs12741800 910 dbSNP
rs1267185229 911 dbSNP
rs1487449840 912 dbSNP
rs915726471 920 dbSNP
rs1250920044 922 dbSNP
rs1441781642 923 dbSNP
rs1176938845 924 dbSNP
rs1379903338 924 dbSNP
rs948672324 925 dbSNP
rs918224479 928 dbSNP
rs951029278 932 dbSNP
rs983867465 941 dbSNP
rs1400810517 942 dbSNP
rs1445013846 942 dbSNP
rs190478482 944 dbSNP
rs1321153993 945 dbSNP
rs942495804 946 dbSNP
rs1314180609 951 dbSNP
rs975293794 954 dbSNP
rs1319886114 958 dbSNP
rs1036330206 961 dbSNP
rs897917932 969 dbSNP
rs1458969009 972 dbSNP
rs994908776 973 dbSNP
rs1237845367 974 dbSNP
rs922448730 976 dbSNP
rs1277085008 978 dbSNP
rs1411632343 979 dbSNP
rs1423755522 980 dbSNP
rs1340391352 988 dbSNP
rs376900666 988 dbSNP
rs74061176 991 dbSNP
rs1007802045 995 dbSNP
rs112795580 996 dbSNP
rs966230270 998 dbSNP
rs977066430 999 dbSNP
rs141413839 1003 dbSNP
rs1376274421 1008 dbSNP
rs1453604226 1016 dbSNP
rs1394935140 1024 dbSNP
rs1222375444 1028 dbSNP
rs946758610 1032 dbSNP
rs1043782619 1034 dbSNP
rs905315936 1035 dbSNP
rs1324540372 1038 dbSNP
rs1002310256 1053 dbSNP
rs1235929609 1053 dbSNP
rs1035165130 1058 dbSNP
rs915762721 1066 dbSNP
rs1187147917 1073 dbSNP
rs372505251 1075 dbSNP
rs565437881 1075 dbSNP
rs1170454573 1079 dbSNP
rs1477102413 1079 dbSNP
rs896653293 1081 dbSNP
rs993724963 1083 dbSNP
rs1177867015 1086 dbSNP
rs561472485 1088 dbSNP
rs377414294 1091 dbSNP
rs1472326468 1094 dbSNP
rs147044682 1095 dbSNP
rs879848783 1096 dbSNP
rs983815024 1103 dbSNP
rs1392415843 1104 dbSNP
rs1277343251 1105 dbSNP
rs1016673441 1108 dbSNP
rs963765030 1127 dbSNP
rs1368108258 1133 dbSNP
rs975583540 1135 dbSNP
rs922429556 1138 dbSNP
rs1217471103 1139 dbSNP
rs540258161 1145 dbSNP
rs933823897 1146 dbSNP
rs1288210418 1148 dbSNP
rs988073991 1149 dbSNP
rs138257770 1164 dbSNP
rs1422681988 1165 dbSNP
rs946707749 1165 dbSNP
rs1419559477 1172 dbSNP
rs889325356 1176 dbSNP
rs1007686253 1177 dbSNP
rs1043731414 1178 dbSNP
rs1297572347 1183 dbSNP
rs905215841 1184 dbSNP
rs1300559581 1188 dbSNP
rs1327567572 1191 dbSNP
rs1438402787 1194 dbSNP
rs1019039132 1195 dbSNP
rs12048905 1206 dbSNP
rs1241066136 1207 dbSNP
rs750165927 1211 dbSNP
rs1244507919 1213 dbSNP
rs1282849460 1215 dbSNP
rs1358660728 1218 dbSNP
rs143924126 1219 dbSNP
rs527684229 1221 dbSNP
rs1219854479 1234 dbSNP
rs760538940 1234 dbSNP
rs1487338053 1238 dbSNP
rs999043014 1240 dbSNP
rs1477499361 1244 dbSNP
rs539175936 1245 dbSNP
rs1437320639 1248 dbSNP
rs1263811391 1251 dbSNP
rs1441828678 1255 dbSNP
rs1185069899 1263 dbSNP
rs1406981916 1264 dbSNP
rs1321350814 1281 dbSNP
rs766269276 1281 dbSNP
rs1349034459 1285 dbSNP
rs1369983013 1293 dbSNP
rs181900008 1294 dbSNP
rs371372047 1304 dbSNP
rs754501024 1306 dbSNP
rs764273170 1306 dbSNP
rs755211115 1310 dbSNP
rs543099319 1314 dbSNP
rs1016583375 1318 dbSNP
rs1284805391 1321 dbSNP
rs1359081532 1324 dbSNP
rs778760541 1326 dbSNP
rs1158792556 1329 dbSNP
rs556568737 1333 dbSNP
rs963716490 1344 dbSNP
rs1395968385 1347 dbSNP
rs975153782 1350 dbSNP
rs1200875641 1357 dbSNP
rs1342663527 1359 dbSNP
rs1453906348 1362 dbSNP
rs1239670091 1368 dbSNP
rs1456134740 1368 dbSNP
rs1029868109 1370 dbSNP
rs970177262 1374 dbSNP
rs1368477135 1376 dbSNP
rs185498393 1378 dbSNP
rs537363759 1388 dbSNP
rs1351867660 1390 dbSNP
rs559561278 1396 dbSNP
rs752370388 1398 dbSNP
rs1261402074 1403 dbSNP
rs1172529226 1410 dbSNP
rs1344133796 1412 dbSNP
rs1398404812 1420 dbSNP
rs528280794 1421 dbSNP
rs967915759 1423 dbSNP
rs1257950094 1430 dbSNP
rs961308683 1431 dbSNP
rs972632485 1442 dbSNP
rs745614878 1449 dbSNP
rs919286125 1450 dbSNP
rs930660230 1455 dbSNP
rs979324517 1461 dbSNP
rs1177817696 1462 dbSNP
rs1381373279 1477 dbSNP
rs116242087 1491 dbSNP
rs1441221917 1492 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 3151.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065669. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' uggaAGGGCUGAAGAGGa 5'
              |||:  ||||||| 
Target 5' uaugUCCU--CUUCUCCc 3'
 		5 - 20
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM1065669
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_8
Location of target site ENST00000361427.5 | 3UTR | UUUUUAUGUCCUCUUCUCCCUUUCCAUCGUUCAGCAUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
158 hsa-miR-5703 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT100581 PIM1 Pim-1 proto-oncogene, serine/threonine kinase 2 2
MIRT134907 CCND2 cyclin D2 2 2
MIRT145067 TNFAIP1 TNF alpha induced protein 1 2 2
MIRT164194 SCOC short coiled-coil protein 2 2
MIRT179547 CAPZA1 capping actin protein of muscle Z-line alpha subunit 1 2 2
MIRT197051 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT202410 RBM38 RNA binding motif protein 38 2 2
MIRT243306 SLC25A36 solute carrier family 25 member 36 2 2
MIRT273441 DAZAP2 DAZ associated protein 2 2 4
MIRT288608 DCAF7 DDB1 and CUL4 associated factor 7 2 2
MIRT324287 LURAP1L leucine rich adaptor protein 1 like 2 2
MIRT338925 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT346169 RAC3 Rac family small GTPase 3 2 2
MIRT370127 TRIB3 tribbles pseudokinase 3 2 2
MIRT442261 FBXW11 F-box and WD repeat domain containing 11 2 2
MIRT443368 PLXNA2 plexin A2 2 2
MIRT443635 ELP6 elongator acetyltransferase complex subunit 6 2 2
MIRT444007 GOLGA8H golgin A8 family member H 2 2
MIRT444019 GOLGA8M golgin A8 family member M 2 2
MIRT444180 HAL histidine ammonia-lyase 2 2
MIRT446553 GOLGA8J golgin A8 family member J 2 2
MIRT448121 CCDC80 coiled-coil domain containing 80 2 2
MIRT449475 ZNF84 zinc finger protein 84 2 2
MIRT449752 SMYD2 SET and MYND domain containing 2 2 2
MIRT450172 KLF7 Kruppel like factor 7 2 2
MIRT451418 TJP3 tight junction protein 3 2 4
MIRT451771 USP36 ubiquitin specific peptidase 36 2 2
MIRT451870 SOD2 superoxide dismutase 2 2 8
MIRT452184 KIAA1456 KIAA1456 2 2
MIRT453514 C14orf144 chromosome 14 open reading frame 144 2 2
MIRT453639 SLC4A2 solute carrier family 4 member 2 2 2
MIRT454010 ALKBH5 alkB homolog 5, RNA demethylase 2 2
MIRT454632 FAM83H family with sequence similarity 83 member H 2 2
MIRT454949 TPM2 tropomyosin 2 2 2
MIRT455358 KDM5C lysine demethylase 5C 2 2
MIRT455591 TAF12 TATA-box binding protein associated factor 12 2 2
MIRT455647 YARS tyrosyl-tRNA synthetase 2 2
MIRT456128 SAMD10 sterile alpha motif domain containing 10 2 2
MIRT456529 TMEM63A transmembrane protein 63A 2 2
MIRT456581 NID1 nidogen 1 2 2
MIRT456780 MTHFSD methenyltetrahydrofolate synthetase domain containing 2 2
MIRT457561 ZNF34 zinc finger protein 34 2 2
MIRT458110 GPIHBP1 glycosylphosphatidylinositol anchored high density lipoprotein binding protein 1 2 2
MIRT458450 RPRM reprimo, TP53 dependent G2 arrest mediator homolog 2 2
MIRT458734 CES2 carboxylesterase 2 2 2
MIRT459767 IDH3A isocitrate dehydrogenase 3 (NAD(+)) alpha 2 2
MIRT459793 POTED POTE ankyrin domain family member D 2 10
MIRT460160 CCL16 C-C motif chemokine ligand 16 2 2
MIRT461799 FXR2 FMR1 autosomal homolog 2 2 2
MIRT462595 MYL12A myosin light chain 12A 2 2
MIRT462708 MAPK13 mitogen-activated protein kinase 13 2 2
MIRT463289 ZFP91 ZFP91 zinc finger protein 2 2
MIRT464780 UBE2G1 ubiquitin conjugating enzyme E2 G1 2 2
MIRT465440 TP53 tumor protein p53 2 2
MIRT465681 TNPO2 transportin 2 2 2
MIRT466543 TBL1XR1 transducin beta like 1 X-linked receptor 1 2 2
MIRT467268 SPOPL speckle type BTB/POZ protein like 2 2
MIRT467430 SND1 staphylococcal nuclease and tudor domain containing 1 2 2
MIRT467587 SLC7A5 solute carrier family 7 member 5 2 6
MIRT469755 RAB2B RAB2B, member RAS oncogene family 2 2
MIRT469984 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT470183 PSMD11 proteasome 26S subunit, non-ATPase 11 2 2
MIRT471057 PIM2 Pim-2 proto-oncogene, serine/threonine kinase 2 2
MIRT471862 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 4
MIRT473386 MBD4 methyl-CpG binding domain 4, DNA glycosylase 2 6
MIRT473891 M6PR mannose-6-phosphate receptor, cation dependent 2 8
MIRT474002 LRRC20 leucine rich repeat containing 20 2 2
MIRT474031 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
MIRT475519 HRK harakiri, BCL2 interacting protein 2 2
MIRT476138 GPR137C G protein-coupled receptor 137C 2 8
MIRT476282 GMFB glia maturation factor beta 2 10
MIRT476364 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT478048 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 10
MIRT479018 COL5A1 collagen type V alpha 1 chain 2 2
MIRT479438 CDKN1A cyclin dependent kinase inhibitor 1A 2 2
MIRT479568 CDC42SE1 CDC42 small effector 1 2 2
MIRT480040 CANX calnexin 2 2
MIRT480213 CABLES1 Cdk5 and Abl enzyme substrate 1 2 2
MIRT482211 AHCYL2 adenosylhomocysteinase like 2 2 2
MIRT482676 NXN nucleoredoxin 2 4
MIRT482817 TRAF6 TNF receptor associated factor 6 2 2
MIRT483404 SPATA6 spermatogenesis associated 6 2 4
MIRT483969 ZADH2 zinc binding alcohol dehydrogenase domain containing 2 2 2
MIRT484204 SUMO1 small ubiquitin-like modifier 1 2 2
MIRT484506 SYT7 synaptotagmin 7 2 2
MIRT485143 RASL10B RAS like family 10 member B 2 2
MIRT487006 C2orf82 chromosome 2 open reading frame 82 2 2
MIRT487924 KCND1 potassium voltage-gated channel subfamily D member 1 2 2
MIRT488393 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT488692 NAT9 N-acetyltransferase 9 (putative) 2 2
MIRT488974 REXO2 RNA exonuclease 2 2 2
MIRT490699 FSTL4 follistatin like 4 2 2
MIRT491740 SEMA3F semaphorin 3F 2 2
MIRT493790 GATA6 GATA binding protein 6 2 2
MIRT494234 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT497254 ELOVL6 ELOVL fatty acid elongase 6 2 2
MIRT501128 SLC2A1 solute carrier family 2 member 1 2 2
MIRT503775 ZNF12 zinc finger protein 12 2 6
MIRT505913 REST RE1 silencing transcription factor 2 2
MIRT506591 MECP2 methyl-CpG binding protein 2 2 4
MIRT507833 CCNT1 cyclin T1 2 2
MIRT510635 TMEM167A transmembrane protein 167A 2 4
MIRT512854 TBC1D13 TBC1 domain family member 13 2 9
MIRT514504 SHISA9 shisa family member 9 2 4
MIRT518899 CDC14B cell division cycle 14B 2 2
MIRT522615 MAP7D1 MAP7 domain containing 1 2 4
MIRT526675 MTMR1 myotubularin related protein 1 2 2
MIRT527325 SIAH3 siah E3 ubiquitin protein ligase family member 3 2 2
MIRT528362 ZMYM1 zinc finger MYM-type containing 1 2 4
MIRT528886 MARC1 mitochondrial amidoxime reducing component 1 2 2
MIRT530656 TRIM56 tripartite motif containing 56 2 2
MIRT537173 GFPT2 glutamine-fructose-6-phosphate transaminase 2 2 4
MIRT547922 HNRNPU heterogeneous nuclear ribonucleoprotein U 2 2
MIRT550416 ORC4 origin recognition complex subunit 4 2 2
MIRT553103 UBXN2A UBX domain protein 2A 2 2
MIRT555885 OTUD7B OTU deubiquitinase 7B 2 4
MIRT556361 MAF MAF bZIP transcription factor 2 2
MIRT557105 HOXA3 homeobox A3 2 2
MIRT560581 LCE1B late cornified envelope 1B 2 2
MIRT560872 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT561529 SOX4 SRY-box 4 2 2
MIRT561989 LRRC58 leucine rich repeat containing 58 2 2
MIRT562048 KPNA6 karyopherin subunit alpha 6 2 2
MIRT562120 IGFBP5 insulin like growth factor binding protein 5 2 2
MIRT562381 EN2 engrailed homeobox 2 2 2
MIRT563935 TAF7 TATA-box binding protein associated factor 7 2 2
MIRT565083 UHRF1BP1 UHRF1 binding protein 1 2 4
MIRT565276 TNFRSF21 TNF receptor superfamily member 21 2 2
MIRT565686 SET SET nuclear proto-oncogene 2 2
MIRT565756 SERTAD2 SERTA domain containing 2 2 2
MIRT568008 CMTM4 CKLF like MARVEL transmembrane domain containing 4 2 2
MIRT569186 LRRC3C leucine rich repeat containing 3C 2 2
MIRT569252 FAM129B family with sequence similarity 129 member B 2 2
MIRT569615 ASTN2 astrotactin 2 2 2
MIRT569690 FMNL3 formin like 3 2 2
MIRT569729 GPR173 G protein-coupled receptor 173 2 2
MIRT569769 SAMD14 sterile alpha motif domain containing 14 2 2
MIRT569822 CRMP1 collapsin response mediator protein 1 2 2
MIRT573272 NCAPH non-SMC condensin I complex subunit H 2 2
MIRT574932 Tbc1d13 TBC1 domain family, member 13 2 6
MIRT612255 ABCC6 ATP binding cassette subfamily C member 6 2 4
MIRT620507 SNRPD1 small nuclear ribonucleoprotein D1 polypeptide 2 2
MIRT627836 POU3F1 POU class 3 homeobox 1 2 2
MIRT630625 ANKRD32 SMC5-SMC6 complex localization factor 1 2 4
MIRT644934 PTCD2 pentatricopeptide repeat domain 2 2 2
MIRT660371 BACH2 BTB domain and CNC homolog 2 2 2
MIRT683345 SCARF1 scavenger receptor class F member 1 2 2
MIRT684975 MINOS1 mitochondrial inner membrane organizing system 1 2 2
MIRT693014 HS2ST1 heparan sulfate 2-O-sulfotransferase 1 2 2
MIRT699483 SLC10A6 solute carrier family 10 member 6 2 2
MIRT703962 EMP2 epithelial membrane protein 2 2 2
MIRT712294 PGM2L1 phosphoglucomutase 2 like 1 2 2
MIRT715896 SIPA1L1 signal induced proliferation associated 1 like 1 2 2
MIRT716635 DPY19L4 dpy-19 like 4 2 2
MIRT717241 HLA-DRB5 major histocompatibility complex, class II, DR beta 5 2 2
MIRT718163 KIAA1958 KIAA1958 2 2
MIRT723309 PRKCH protein kinase C eta 2 2
MIRT755589 SRC SRC proto-oncogene, non-receptor tyrosine kinase 5 1
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-5703 Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-mir-5703 Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-5703 Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-5703 Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-5703 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-5703 Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)

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