miRTarBase - #MIRT345117


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pre-miRNA Information
pre-miRNA hsa-mir-6756   
Genomic Coordinates chr11: 119312950 - 119313012
Description Homo sapiens miR-6756 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6756-3p
Sequence 44| UCCCCUUCCUCCCUGCCCAG |63
Evidence Experimental
Experiments Meta-analysis
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1411959960 15 dbSNP
rs150069507 19 dbSNP
rs369323848 19 dbSNP
Putative Targets

Gene Information
Gene Symbol ATXN7L3   
Synonyms -
Description ataxin 7 like 3
Transcript NM_001098833   
Other Transcripts NM_020218   
Expression
Putative miRNA Targets on ATXN7L3
3'UTR of ATXN7L3
(miRNA target sites are highlighted)		 
>ATXN7L3|NM_001098833|3'UTR
   1 CTTGGGTGCAAGGGATAGCCTTTGGCTGAGCAGAGCCCTCTCTCCTGACCCCCACCCAGGTGGCATAGCCTGGCAAATGG
  81 ACGGCTGCTGGGGGTTGGGGCTTGGGAAGCTTGGTGGGCCAGGCAGGCAGAGGATCCGATTATGCGCCCCTGGGGGGTGT
 161 CAAAGTCCTCTGCAATGGAGCACGACTCCTCGGCGTGCAGGACTCAGACCTGGACATATTATGCCTTGGACATAAGTTTG
 241 GTGGGGAGGCGGTTTTCCTATTTATTCTGTGAGTTACTGGATGTCCAGCTAGGCCAGGGGCCTGACCTGGGCACTGTGCC
 321 AGGGCACTGCCTGCCCCCCACCCCAGGAACTGGACTAAGCCCTGCTGAGGGGCAATGTGGCGACCCGGGAGGCTGTGGGT
 401 TGGAAGCTGAGCCTGGAGGGGGCCTGCCTCGGCCGCCCTCAGCAATGTGAATGGGTCCGGTGCTTGGAGCTGAGGGGCAA
 481 GGCTGGGCATGTCCTGTCTGTGTGCAGAATCTTATCAAATGCCCCCAGTCCCAGGGGTAGGCAGGCACAGAGTGCTGTCT
 561 GCTGAGGTGGGCGTCCAGAACTGCCGCCACCTTCCCTGCCCCTCACAGGGGCAGCCCTTTCCCCTCAGTCCCCATGGGCC
 641 TCCTTGGCAGCAGGAGCTGTCCTTTTGTTGGGTGCCAGGAAAGGGCCTCCAGCCTCTACAGCTTCAAGGAATGGGAAAGG
 721 GAGGGTAGGAAGAGGGAGAAGTGTCAGAATTCCTCCCCCTGCCTCTCCTCCCTGACCCAGGGCTGGTGAGGAGTGGGGCC
 801 CCAAGGTGAGAGGGAACGGTGCTGCTTTATTTGAAATGTTTTCTTACCTCATTCCCTGCCCCAGGAAGGGACCCAGCCTC
 881 ACCCTCCTGGGGTGGCCCCGTGTTCCTCCTGCCCACCCTGCCCCACTGCCCTACCGGGGCAGCCCAGGTTCCCAACTGCT
 961 GCTTCCACCCCCTTCACCTTGACTGGCTTCAGTTCCTCTCAGCGCTCCTGCCTCCAAAGCGTGCCCTGTTTCCCTTCCTT
1041 AGCGCTTTTAAGTTATTTATTCTGTACTTGTGGTTTGGGGCTCTGAGGAAAATCCTAATCTTGTGCCTCTCCCCCTTTGC
1121 TAGGAGTTGGGTGGGAAGAGAGGGTGGCCTCTGTGCCCCAGGTTGTCAGTGGAGGGGAAGGGGTGTCACTGCCCCTCTGT
1201 GGGACTGTCATGCCAGTGTGCCCACCTGCCTGGTCTACATCCTAAAGAGATGTACCGTCCCCCCTCCATGCGGGCACCAC
1281 CACTCCCAGGAGCCAAGCTGGAGGACCGCGACCTGGGCTGGGAGCAGAGCTGACTGACATGGGTGGAGGTGACCCTGAGC
1361 CAAGTTCTCTGGCACTTGCTGGACATGTCCCCTACCCTCTTCCCAAGAGGAGCCATCCCACATTTGGGTAGTTAGTACCC
1441 AGGACTGGTTGGACTGATCGGGTTAGGGACCCTAGAGGGTTAAGGGAACAACAGAGATGGGGCTGCAATGCCCTGTCTGG
1521 AACTCCGCTCTCCCGCTGGGGTGGTTCTGATTGTGGCTCATGCCTGGTTGCAAATTGGTTTTTAACCCACAAATTGTGAT
1601 TATTTTTTAAAAAGCCAAACAGATTTTGGCAGGAGTTAGAATAAATCCCGGGGCCTGGGCTTCTCTATTCTTGGCCCTCC
1681 GTAGTCTCCCTCCGAGAGGAGGCCAGAGGGAGAGGAGGATCTCAGCAGGCCTCTAGCCGCTTCCAGATGCAGTCTGGGGA
1761 GTGGGCTGAAGGTGAAGGGAGGAAGGCTGTGGGCCACTCTCCCTTCTGAGAGGCAGCTGCAGCTCAGGCCCTAATACACT
1841 CTTTGCCCTGTGGCCTCTCCCTTTTCCCCCCTTCTGGTTGGAGGAGGGAGAAGTGGGAAGTAGCTTGGGAACTGGTTTGT
1921 CCACATAAACTTCCCCATTGTTCCTTGGCCCGCCCTCAGGGCAGAGCCCCCTGCCCAGGCTGGGTAAGAGATGGGCTTGG
2001 TCCAGCAGGGACCCTGAGGGAACAAACCCTTTTCCTTCTGGGGAGAGAGTGCCCCCCCTACCATGTAGTTGAACAGGGGC
2081 TAGGAGCTCCCCACTCCCCTCCCTCTAACAGCAGGCTGTGTGGGTTTCAATTCCCATCCTTCCCACCCCGGCTAGGTGTC
2161 GTCCACCCTGTATCCTGTGTCTGAGTGTGTGTGGGGGGGTTCTGTACTAATTTCCATGGCCGGTGGCTTTTCCTTCCATG
2241 CATCACTCCCCCCCGCATGCCCAGGGGCCACCCGCCTGGCATTACCGCATGCTGGGGTCATTGGGGGAGGGGGGTGGGGC
2321 TCACGCTGTCCTGTGGTCTTGAGATTTTTATTTTTGCATATGTAATCCATTCTGTACAGGTAGCTAACTTTGTAAACGCT
2401 GTGTATTCCCTCTGCCCCCATGGCTGCTGGTGTAAATAAACTGCATCTCCCGTTGGTAAAAAAAAAAAAAAAAAAAAAAA
2481 AAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gaccCGUCCCUCCUUCCCCu 5'
              |::| |:|||||||| 
Target 5' gtcaGTGGAGGGGAAGGGGt 3'
 1165 - 1184 160.00 -22.90
2 
miRNA  3' gaCCCGUCCCUCCUUCCCCu 5'
            || ||  |:||:||||| 
Target 5' ggGGTCATTGGGGGAGGGGg 3'
 2294 - 2313 146.00 -27.40
3 
miRNA  3' gaCCCGUCCCUCCUUCCCCu 5'
            ||| :|| |||||| || 
Target 5' aaGGGAGGGTAGGAAGAGGg 3'
 717 - 736 138.00 -27.20
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gaCCCGUCCCUCCUUCCccu 5'
            | | |||||||||||   
Target 5' agGUGAAGGGAGGAAGGcug 3'
 		12 - 31
2 
miRNA  3' gacccgucccucCUUCCCCu 5'
                      ||: ||| 
Target 5' ------------GAGUGGGc 3'
 		1 - 8
Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000454077.2 | 3UTR | GAGUGGGCUGAAGGUGAAGGGAGGAAGGCUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
179 hsa-miR-6756-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT069654 BCL2L2-PABPN1 BCL2L2-PABPN1 readthrough 2 2
MIRT069666 PABPN1 poly(A) binding protein nuclear 1 2 2
MIRT123234 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT150220 MIDN midnolin 2 2
MIRT246309 HIST2H2AA3 histone cluster 2 H2A family member a3 2 2
MIRT246321 HIST2H2AA4 histone cluster 2 H2A family member a4 2 2
MIRT338417 ANKRD52 ankyrin repeat domain 52 2 2
MIRT338804 STMN1 stathmin 1 2 2
MIRT345117 ATXN7L3 ataxin 7 like 3 2 2
MIRT360222 SOX4 SRY-box 4 2 2
MIRT360816 GLO1 glyoxalase I 2 2
MIRT384636 SP1 Sp1 transcription factor 2 2
MIRT446400 SNX1 sorting nexin 1 2 2
MIRT447475 ATP10D ATPase phospholipid transporting 10D (putative) 2 2
MIRT477796 E2F2 E2F transcription factor 2 2 2
MIRT479381 CELF1 CUGBP Elav-like family member 1 2 6
MIRT495240 RHEBL1 RHEB like 1 2 2
MIRT495313 GDF11 growth differentiation factor 11 2 2
MIRT495953 SLC12A7 solute carrier family 12 member 7 2 2
MIRT496425 ACTRT3 actin related protein T3 2 2
MIRT504108 FLOT1 flotillin 1 2 2
MIRT506765 KMT2D lysine methyltransferase 2D 2 2
MIRT520355 UBE2K ubiquitin conjugating enzyme E2 K 2 4
MIRT520794 TBRG1 transforming growth factor beta regulator 1 2 4
MIRT529620 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT532385 UMPS uridine monophosphate synthetase 2 2
MIRT533386 UBA6 ubiquitin like modifier activating enzyme 6 2 2
MIRT533944 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 2
MIRT537069 GPR176 G protein-coupled receptor 176 2 2
MIRT556424 LONRF3 LON peptidase N-terminal domain and ring finger 3 2 2
MIRT560755 ARMC10 armadillo repeat containing 10 2 2
MIRT566476 PDCD4 programmed cell death 4 2 2
MIRT567249 HSP90AA1 heat shock protein 90 alpha family class A member 1 2 2
MIRT570547 PRMT7 protein arginine methyltransferase 7 2 2
MIRT572756 FAM204A family with sequence similarity 204 member A 2 2
MIRT573088 APLN apelin 2 2
MIRT573236 GALNT8 polypeptide N-acetylgalactosaminyltransferase 8 2 2
MIRT575503 Ankle1 ankyrin repeat and LEM domain containing 1 2 6
MIRT606952 ANKLE1 ankyrin repeat and LEM domain containing 1 2 9
MIRT609247 SERPINA4 serpin family A member 4 2 2
MIRT609348 ZNF664 zinc finger protein 664 2 2
MIRT609475 LSAMP limbic system-associated membrane protein 2 2
MIRT610253 LRRC47 leucine rich repeat containing 47 2 2
MIRT610404 RXRB retinoid X receptor beta 2 2
MIRT612091 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT612222 EPX eosinophil peroxidase 2 4
MIRT613599 SCN1A sodium voltage-gated channel alpha subunit 1 2 2
MIRT614425 TAZ tafazzin 2 2
MIRT615143 ACVR2B activin A receptor type 2B 2 2
MIRT616784 CD44 CD44 molecule (Indian blood group) 2 2
MIRT619132 MCOLN3 mucolipin 3 2 2
MIRT619309 KIRREL kirre like nephrin family adhesion molecule 1 2 2
MIRT619988 ZSCAN22 zinc finger and SCAN domain containing 22 2 2
MIRT620196 VN1R1 vomeronasal 1 receptor 1 2 2
MIRT620467 CERS6 ceramide synthase 6 2 2
MIRT621247 QTRT1 queuine tRNA-ribosyltransferase catalytic subunit 1 2 2
MIRT623538 KCNJ6 potassium voltage-gated channel subfamily J member 6 2 2
MIRT624218 DCAF5 DDB1 and CUL4 associated factor 5 2 2
MIRT624497 CABP4 calcium binding protein 4 2 2
MIRT627849 PLCXD3 phosphatidylinositol specific phospholipase C X domain containing 3 2 2
MIRT628261 EFCAB14 EF-hand calcium binding domain 14 2 2
MIRT637347 PIGP phosphatidylinositol glycan anchor biosynthesis class P 2 2
MIRT640074 KCNMB4 potassium calcium-activated channel subfamily M regulatory beta subunit 4 2 2
MIRT640578 MYO5A myosin VA 2 2
MIRT641444 PELO pelota mRNA surveillance and ribosome rescue factor 2 2
MIRT641881 SND1 staphylococcal nuclease and tudor domain containing 1 2 2
MIRT642422 CILP2 cartilage intermediate layer protein 2 2 2
MIRT642834 KIAA0319 KIAA0319 2 2
MIRT643516 CCDC115 coiled-coil domain containing 115 2 2
MIRT643624 YY2 YY2 transcription factor 2 2
MIRT644202 LAT2 linker for activation of T-cells family member 2 2 2
MIRT644212 CBS cystathionine-beta-synthase 2 2
MIRT644364 NDUFAF6 NADH:ubiquinone oxidoreductase complex assembly factor 6 2 2
MIRT645177 NOL9 nucleolar protein 9 2 4
MIRT645371 C9orf47 chromosome 9 open reading frame 47 2 2
MIRT646254 PRSS38 protease, serine 38 2 2
MIRT646543 KLK2 kallikrein related peptidase 2 2 2
MIRT646577 XPNPEP3 X-prolyl aminopeptidase 3 2 2
MIRT646640 COA4 cytochrome c oxidase assembly factor 4 homolog 2 2
MIRT647119 ZNF446 zinc finger protein 446 2 2
MIRT647168 TMLHE trimethyllysine hydroxylase, epsilon 2 2
MIRT647416 SSTR3 somatostatin receptor 3 2 2
MIRT647432 ZKSCAN2 zinc finger with KRAB and SCAN domains 2 2 2
MIRT647515 HSPA5 heat shock protein family A (Hsp70) member 5 2 2
MIRT647583 RBMXL1 RNA binding motif protein, X-linked like 1 2 2
MIRT648148 SUCLG2 succinate-CoA ligase GDP-forming beta subunit 2 2
MIRT648646 ZNF562 zinc finger protein 562 2 2
MIRT649579 PALD1 phosphatase domain containing, paladin 1 2 2
MIRT649721 TWSG1 twisted gastrulation BMP signaling modulator 1 2 2
MIRT649792 LPCAT3 lysophosphatidylcholine acyltransferase 3 2 2
MIRT649807 GALC galactosylceramidase 2 2
MIRT649957 RCBTB1 RCC1 and BTB domain containing protein 1 2 2
MIRT650130 ABCB7 ATP binding cassette subfamily B member 7 2 2
MIRT650481 UFM1 ubiquitin fold modifier 1 2 2
MIRT650730 TNFSF8 TNF superfamily member 8 2 2
MIRT650966 STARD3NL STARD3 N-terminal like 2 4
MIRT651010 ZNF740 zinc finger protein 740 2 2
MIRT651122 ZNF48 zinc finger protein 48 2 2
MIRT651301 ZDHHC21 zinc finger DHHC-type containing 21 2 2
MIRT651827 USP49 ubiquitin specific peptidase 49 2 2
MIRT651969 UBE2J1 ubiquitin conjugating enzyme E2 J1 2 2
MIRT652028 TTPAL alpha tocopherol transfer protein like 2 2
MIRT652286 TNS4 tensin 4 2 2
MIRT652712 THBS2 thrombospondin 2 2 2
MIRT652790 TCEANC2 transcription elongation factor A N-terminal and central domain containing 2 2 2
MIRT653333 SMIM18 small integral membrane protein 18 2 2
MIRT653866 SHANK2 SH3 and multiple ankyrin repeat domains 2 2 2
MIRT654046 SAMD12 sterile alpha motif domain containing 12 2 2
MIRT654802 PRICKLE1 prickle planar cell polarity protein 1 2 2
MIRT654818 PPP3R1 protein phosphatase 3 regulatory subunit B, alpha 2 2
MIRT654955 PMEPA1 prostate transmembrane protein, androgen induced 1 2 2
MIRT655165 PHF20L1 PHD finger protein 20 like 1 2 2
MIRT655397 PANK3 pantothenate kinase 3 2 2
MIRT655422 PAN2 PAN2 poly(A) specific ribonuclease subunit 2 2
MIRT655656 NUPL2 nucleoporin like 2 2 2
MIRT655682 NUMBL NUMB like, endocytic adaptor protein 2 2
MIRT655713 MLF2 myeloid leukemia factor 2 2 2
MIRT655915 NEDD9 neural precursor cell expressed, developmentally down-regulated 9 2 2
MIRT655955 NDST1 N-deacetylase and N-sulfotransferase 1 2 2
MIRT656198 MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 2 2
MIRT656374 MDFI MyoD family inhibitor 2 2
MIRT656742 LMBR1L limb development membrane protein 1 like 2 2
MIRT656763 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT656832 KLF8 Kruppel like factor 8 2 2
MIRT657165 IP6K1 inositol hexakisphosphate kinase 1 2 2
MIRT657744 GNG12 G protein subunit gamma 12 2 2
MIRT657921 GCC1 GRIP and coiled-coil domain containing 1 2 2
MIRT658201 FBXO44 F-box protein 44 2 2
MIRT658418 FAM199X family with sequence similarity 199, X-linked 2 2
MIRT658843 DUSP22 dual specificity phosphatase 22 2 2
MIRT659208 CYBB cytochrome b-245 beta chain 2 2
MIRT659223 CXXC5 CXXC finger protein 5 2 2
MIRT660045 C15orf61 chromosome 15 open reading frame 61 2 2
MIRT660267 BLOC1S5 biogenesis of lysosomal organelles complex 1 subunit 5 2 4
MIRT660575 AQR aquarius intron-binding spliceosomal factor 2 2
MIRT660719 AMER1 APC membrane recruitment protein 1 2 2
MIRT660929 ADAM19 ADAM metallopeptidase domain 19 2 2
MIRT661580 EPHX2 epoxide hydrolase 2 2 2
MIRT662151 IPO11 importin 11 2 2
MIRT662366 TADA2A transcriptional adaptor 2A 2 2
MIRT663317 TECPR2 tectonin beta-propeller repeat containing 2 2 2
MIRT663816 RNF128 ring finger protein 128, E3 ubiquitin protein ligase 2 2
MIRT666621 REEP2 receptor accessory protein 2 2 2
MIRT667798 JHDM1D lysine demethylase 7A 1 1
MIRT668598 EIF2AK2 eukaryotic translation initiation factor 2 alpha kinase 2 2 2
MIRT668653 DYM dymeclin 2 2
MIRT668761 DDR2 discoidin domain receptor tyrosine kinase 2 2 2
MIRT669375 BAHD1 bromo adjacent homology domain containing 1 2 2
MIRT687529 NASP nuclear autoantigenic sperm protein 2 2
MIRT693229 KIAA0907 KIAA0907 2 4
MIRT697711 WAC WW domain containing adaptor with coiled-coil 2 2
MIRT700569 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT710933 ING5 inhibitor of growth family member 5 2 2
MIRT710974 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT711826 MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3 2 2
MIRT712709 FGFR1OP2 FGFR1 oncogene partner 2 2 2
MIRT712732 NCAPG2 non-SMC condensin II complex subunit G2 2 2
MIRT713034 MAP3K2 mitogen-activated protein kinase kinase kinase 2 2 2
MIRT714200 TRAF7 TNF receptor associated factor 7 2 2
MIRT714869 LLPH LLP homolog, long-term synaptic facilitation 2 2
MIRT715247 DHODH dihydroorotate dehydrogenase (quinone) 2 2
MIRT715922 ACVRL1 activin A receptor like type 1 2 2
MIRT716239 METTL21A methyltransferase like 21A 2 2
MIRT716974 GTDC1 glycosyltransferase like domain containing 1 2 2
MIRT718949 CLMN calmin 2 2
MIRT719575 TYRO3 TYRO3 protein tyrosine kinase 2 2
MIRT721631 DNAJC30 DnaJ heat shock protein family (Hsp40) member C30 2 2
MIRT721830 POU6F1 POU class 6 homeobox 1 2 2
MIRT722293 DMRTB1 DMRT like family B with proline rich C-terminal 1 2 2
MIRT722639 C8A complement C8 alpha chain 2 2
MIRT722898 LRRC20 leucine rich repeat containing 20 2 2
MIRT723073 GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 2 2
MIRT723392 CALN1 calneuron 1 2 2
MIRT724183 GDF6 growth differentiation factor 6 2 2
MIRT724249 TENM4 teneurin transmembrane protein 4 2 2
MIRT724369 ASGR1 asialoglycoprotein receptor 1 2 2
MIRT724514 KLHL5 kelch like family member 5 2 2
MIRT724579 NOTCH2 notch 2 2 2
MIRT724714 CRAMP1L cramped chromatin regulator homolog 1 2 2

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