miRTarBase - #MIRT347727


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pre-miRNA Information
pre-miRNA hsa-mir-548ac   
Genomic Coordinates chr1: 116560024 - 116560111
Description Homo sapiens miR-548ac stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-548ac
Sequence 53| CAAAAACCGGCAAUUACUUUUG |74
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 1 - 116560056 29233923 MiREDiBase
A-to-I 5 1 - 116560055 29233923 MiREDiBase
A-to-I 6 1 - 116560054 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1182074110 6 dbSNP
rs1392446444 6 dbSNP
rs1326234665 7 dbSNP
rs556579863 8 dbSNP
rs993390910 9 dbSNP
rs901450363 13 dbSNP
rs538553306 22 dbSNP
Putative Targets

Gene Information
Gene Symbol LSM14A   
Synonyms C19orf13, FAM61A, RAP55, RAP55A
Description LSM14A, mRNA processing body assembly factor
Transcript NM_001114093   
Other Transcripts NM_015578   
Expression
Putative miRNA Targets on LSM14A
3'UTR of LSM14A
(miRNA target sites are highlighted)		 
>LSM14A|NM_001114093|3'UTR
   1 AAGGTCTGGATTGATCGTACTGCTTTCTGAAAGAAAGACAACAAAGTTGCTGCATAGTCTACAAACAAGTCTCTGAAAAT
  81 AGGTGAATTTCTAGCTCTTCATGGTCCTGAACATTGATTTCAGTCTTTGCAAAGAATGAAGAAGTGAATTCGCTGTACAT
 161 TTGTCACCAGCACTGGGTTTTTGTTTTTTGTTTGTTTTTCCGCTTAATTTCAAAGATAAAATGCAGTTACTTTTGGGGGT
 241 GGAAGGCTCATCTTAAAACATGAGCATTAAATATATTTGGAATAGCAGAAGGTTAAGTAATTTCTTATGTATAGTTAAAC
 321 TAAAGCAGTACTTCAGTGGGACTTAACAAGTATTTTTTCATCACTGAAAGGTTTTTTTTTTTTATCACTAAATTGTATTT
 401 GGCAATTGCAAGTTGCCTGCAGATAGGGCCGTGATACTGTGTTTTGAGCCACAGAAGGTTGTGTGTGTGTGTGTGTGTGT
 481 GTGTGTGTGTGTGTGTGTATGTGTGTGTCTTTTTCCTCCTTTCTTTTGGGGAATCCTGTAATATGAGGTAGCTTATTTCG
 561 TCAATTAATTAGGGTGCTGGATGGTAGAGAATTTTGTCAGTCAACTATGTACACACAGTAAATACTGTTTCTTAGGCAAA
 641 GGTAACTTTTTTATATAGTTGTAAAATTCCATTATATTCCATTGCCAAAGAAACATTAAGAACTTTGTATAGCTGTATAA
 721 AAAGCAACTAATTTTTTAAAGAATAAACATTTTAAAGTCAGCAAACATACTGTGTCCTTGCAGAAGTTGATGTGCTGAGC
 801 AGCAGCCTTATGGGTGGGTCTTTTTTTCTTAGTTTTCCAGGCTTAACATTTTTGATTTTGTTTTTTAATGTTTGGAACAT
 881 AAATGAAGATTTGATACATTATTTCATTATCTAAAAAGGATTAATTATTCATGCTCATTGTAAGAACTTCATTTTGTAGC
 961 AAATGGCATATCACAGGATCTGTCCAGATAATCGATATTTTCAGTATACAAATGTAAATAATCACAGATGAGAATGTACT
1041 TAGCTGTATTTTCAAATAAGTAATCTTCCCCCCTTTTGTAGGACTTTAAAACTAGGCATCAATGAACCTGTTTTTCCTAT
1121 TATGCCTGGAATTTAGTCATGATACCTTGACTCATTCCATCATATTTCAAGAGGATTCAGAGTGCTAGAAATTATTTTGG
1201 TAGCCTGTAACACACGGCAACACTGGTCCTTGGGCCTATGATGACCCACAGATGACTCAGTATAGAGTTCATTGCTAATT
1281 ATAAATTACTAGTGAATCTTTTTGATATTTTAAGCTCTAGTGGGAAAAATCTGGCCACTTTTGTGTTTTTATGAAGGCCA
1361 TGGAATAAAAGGATCCAAAGATTTAAATATTTTTATCTAATATTTTGATTGTTTTCTTAACTTTCTCCTTAAAACATTCA
1441 GTAGTGATAAAGATATAGAAACTGCACTGTAGGAGAATTGGAATATTTAAGGCTGGTTGACATTTTTTATTTTCATTTTA
1521 TATCTTTTGTATAGCTCTACAAGGCAGTGTTTTGTAATTTGGTTTCATTATGAAGATCCAGTACTTGGCAGCCATAGTTT
1601 AGACAATATTGTTCAGTGCTGTTTGCTTGCATGTTAACAACAAAACCTTTTAGAGGACCCACAAATCATGATATTGAACA
1681 CAGTTCCGAGGCATTCAGAGCATCAGAGCAAGTACCATGGCAATACATGTGTAGACTGTTGGAGATGTCCCGGGCCAATT
1761 TCAAGAAAGAAAACTGTAAATACTAGTTCTACTTGCTCTGAAATTATGAGTTTATGCGTTTTCCCAGCCCTCCGAATCAC
1841 TGACTGGGGCGTTTTGTGCCCCAGCAATAACTGGCAGCATGGCATACCTGCAGTACCCCTTACAATATTAAAGCAAAGTT
1921 TTTATTCTAAAACAGAATAAAACTGTTCAATAAAAAATGCTCGTCAAAGTTCTTTCTCTTTAAATAGTAACATTCTGTTT
2001 CAGTAGGAACATAATGAAAGGAATCTTTTAAATGGAAGAGCGGAATTATAATGTTTGTATTCCCTGTAATAACTATAAAT
2081 CAGTTACTTTATTTCTAAGATTGAGTTATTGTTGCAGATGTTTAGGGAAAGCTAAAAGCCCCTTCCTTCCCCTCCTGTGT
2161 GTAAATAAAATACTTCTGAGATCA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' guuUUCAUUAACGG-----------CCAAAAAc 5'
             ||||| || ::           ||||||| 
Target 5' aacAAGTATTTTTTCATCACTGAAAGGTTTTTt 3'
 345 - 377 143.00 -5.20
2 
miRNA  3' guuuucauUAACGGCCAAAAAc 5'
                  | ||  ||||||| 
Target 5' tcaccagcACTG--GGTTTTTg 3'
 164 - 183 142.00 -9.10
3 
miRNA  3' guuuuCAUUAACGGCCAAAaac 5'
               ||||||  :|||||   
Target 5' gttttGTAATT--TGGTTTcat 3'
 1549 - 1568 121.00 -6.62
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN28838419 44 COSMIC
COSN28866483 44 COSMIC
COSN30571079 153 COSMIC
COSN8605607 154 COSMIC
COSN29336198 158 COSMIC
COSN30582238 166 COSMIC
COSN16741449 586 COSMIC
COSN28718901 690 COSMIC
COSN24306763 889 COSMIC
COSN30660541 925 COSMIC
COSM6704678 947 COSMIC
COSN26983197 983 COSMIC
COSN30453713 1001 COSMIC
COSN30188455 1004 COSMIC
COSN20079289 1019 COSMIC
COSN30525466 1026 COSMIC
COSN31511574 1035 COSMIC
COSN30184947 1039 COSMIC
COSN31587753 1052 COSMIC
COSN31572988 1102 COSMIC
COSN16793353 1103 COSMIC
COSN31588503 1202 COSMIC
COSN31569553 1203 COSMIC
COSN31558459 1205 COSMIC
COSN17037843 1230 COSMIC
COSN21228250 1244 COSMIC
COSN19661767 1284 COSMIC
COSN1766884 1304 COSMIC
COSN31483159 1334 COSMIC
COSN14669490 1398 COSMIC
COSN20115739 1399 COSMIC
COSN27330130 1399 COSMIC
COSN16168918 1400 COSMIC
COSN6143086 1511 COSMIC
COSN31547336 1644 COSMIC
COSN31489627 1655 COSMIC
COSN28793565 1723 COSMIC
COSN31516673 1791 COSMIC
COSN25705511 1832 COSMIC
COSN31535967 1867 COSMIC
COSN31516983 1912 COSMIC
COSN6143087 1970 COSMIC
COSN20115740 2045 COSMIC
COSN1214494 2046 COSMIC
COSN1214495 2048 COSMIC
COSN20115741 2143 COSMIC
COSN31585176 2190 COSMIC
COSN30164620 2218 COSMIC
COSN7125023 2276 COSMIC
COSN31585180 2284 COSMIC
COSN29072729 2308 COSMIC
COSN31585806 2326 COSMIC
COSN31527463 2417 COSMIC
COSN25915981 2635 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1011078122 4 dbSNP
rs1396149451 8 dbSNP
rs1309900819 9 dbSNP
rs1401758557 10 dbSNP
rs1264103635 15 dbSNP
rs1489664055 17 dbSNP
rs754102967 18 dbSNP
rs868378595 19 dbSNP
rs755347788 25 dbSNP
rs1447154625 31 dbSNP
rs754110489 36 dbSNP
rs780222088 36 dbSNP
rs765558032 42 dbSNP
rs1375221973 44 dbSNP
rs752388905 45 dbSNP
rs1419567871 49 dbSNP
rs1404742064 50 dbSNP
rs1159411288 51 dbSNP
rs1029205166 53 dbSNP
rs1162578004 54 dbSNP
rs1351468333 56 dbSNP
rs1458159221 59 dbSNP
rs1326841542 60 dbSNP
rs1388124092 62 dbSNP
rs1433032734 66 dbSNP
rs758179579 68 dbSNP
rs1362729745 69 dbSNP
rs750949038 72 dbSNP
rs1228311693 74 dbSNP
rs1311203368 80 dbSNP
rs1323884761 82 dbSNP
rs754493520 83 dbSNP
rs953545664 86 dbSNP
rs868244902 87 dbSNP
rs925946206 106 dbSNP
rs987693075 110 dbSNP
rs111365500 112 dbSNP
rs937606349 122 dbSNP
rs538560263 126 dbSNP
rs1259836703 130 dbSNP
rs962176310 130 dbSNP
rs1356852244 131 dbSNP
rs972576421 133 dbSNP
rs1413483969 134 dbSNP
rs879533758 142 dbSNP
rs1355444578 146 dbSNP
rs1299181806 152 dbSNP
rs920566980 153 dbSNP
rs1383042613 155 dbSNP
rs878916583 156 dbSNP
rs1158233736 169 dbSNP
rs1391681335 173 dbSNP
rs554652945 176 dbSNP
rs1162950146 181 dbSNP
rs930639465 184 dbSNP
rs1263868267 194 dbSNP
rs1380371884 197 dbSNP
rs1048338631 204 dbSNP
rs1195038221 225 dbSNP
rs916534491 226 dbSNP
rs1323456740 230 dbSNP
rs917413045 231 dbSNP
rs1046251419 236 dbSNP
rs1336217550 237 dbSNP
rs1270711454 244 dbSNP
rs1249695809 246 dbSNP
rs79246173 257 dbSNP
rs1334730276 268 dbSNP
rs1036529326 272 dbSNP
rs193088622 283 dbSNP
rs893436005 299 dbSNP
rs146647802 300 dbSNP
rs1029195274 302 dbSNP
rs953661632 303 dbSNP
rs576008748 306 dbSNP
rs529213959 309 dbSNP
rs540688830 310 dbSNP
rs761596102 311 dbSNP
rs1461034498 313 dbSNP
rs542964753 322 dbSNP
rs1169614087 326 dbSNP
rs888081653 330 dbSNP
rs962536350 333 dbSNP
rs1372298443 336 dbSNP
rs576964024 338 dbSNP
rs670286 339 dbSNP
rs965265366 343 dbSNP
rs1332999942 345 dbSNP
rs952016688 347 dbSNP
rs1274275188 354 dbSNP
rs991515946 354 dbSNP
rs916482619 365 dbSNP
rs1269975418 369 dbSNP
rs1403483653 375 dbSNP
rs1235529948 377 dbSNP
rs998000138 384 dbSNP
rs781157811 385 dbSNP
rs1355194696 387 dbSNP
rs1330748140 389 dbSNP
rs555966996 392 dbSNP
rs141426907 408 dbSNP
rs745773593 415 dbSNP
rs1174000943 419 dbSNP
rs1455462200 428 dbSNP
rs1392827614 430 dbSNP
rs1192652264 435 dbSNP
rs978844455 438 dbSNP
rs1052189772 440 dbSNP
rs1380989137 442 dbSNP
rs11673180 452 dbSNP
rs1201909869 458 dbSNP
rs946375303 464 dbSNP
rs1050077675 466 dbSNP
rs561495553 470 dbSNP
rs1301433359 471 dbSNP
rs1233858383 473 dbSNP
rs1374412087 474 dbSNP
rs1281350254 480 dbSNP
rs527281429 497 dbSNP
rs1353838496 506 dbSNP
rs1313434686 507 dbSNP
rs1436313088 512 dbSNP
rs749484453 514 dbSNP
rs541084102 515 dbSNP
rs1019623935 516 dbSNP
rs917547303 523 dbSNP
rs774708424 539 dbSNP
rs564164274 564 dbSNP
rs972239019 568 dbSNP
rs502810 578 dbSNP
rs1278609646 583 dbSNP
rs866493528 596 dbSNP
rs76310788 603 dbSNP
rs1261602962 604 dbSNP
rs1210706476 610 dbSNP
rs1317716364 616 dbSNP
rs772538569 617 dbSNP
rs1027726904 620 dbSNP
rs1222098525 621 dbSNP
rs1478412114 623 dbSNP
rs1293762009 632 dbSNP
rs1416557246 635 dbSNP
rs559536659 642 dbSNP
rs1048110414 658 dbSNP
rs1312013110 660 dbSNP
rs1426504066 665 dbSNP
rs1346547377 683 dbSNP
rs1468979108 696 dbSNP
rs1156531162 697 dbSNP
rs552784907 698 dbSNP
rs1022942021 703 dbSNP
rs1476473283 713 dbSNP
rs1360746676 721 dbSNP
rs1256076847 730 dbSNP
rs569471466 737 dbSNP
rs1486412060 738 dbSNP
rs1288262123 739 dbSNP
rs1213917982 745 dbSNP
rs1316355564 746 dbSNP
rs1362616701 748 dbSNP
rs531879191 749 dbSNP
rs1235259328 751 dbSNP
rs1332560072 755 dbSNP
rs761201892 756 dbSNP
rs1280191816 761 dbSNP
rs143370812 767 dbSNP
rs529052053 776 dbSNP
rs1343706094 784 dbSNP
rs982009972 787 dbSNP
rs568317607 788 dbSNP
rs184989652 789 dbSNP
rs901128575 801 dbSNP
rs189162931 816 dbSNP
rs1416270389 822 dbSNP
rs998026499 830 dbSNP
rs1164734453 842 dbSNP
rs694804 844 dbSNP
rs1429419732 847 dbSNP
rs1422114426 848 dbSNP
rs1464610207 853 dbSNP
rs1215583867 858 dbSNP
rs1253922313 858 dbSNP
rs1272398081 863 dbSNP
rs1467220339 863 dbSNP
rs746552447 887 dbSNP
rs757095314 892 dbSNP
rs570588734 897 dbSNP
rs745837070 903 dbSNP
rs769627806 904 dbSNP
rs1180046410 906 dbSNP
rs527746776 909 dbSNP
rs779881803 911 dbSNP
rs1475424349 913 dbSNP
rs1158095691 914 dbSNP
rs181820603 916 dbSNP
rs1386147552 922 dbSNP
rs556049561 943 dbSNP
rs1320524542 945 dbSNP
rs867093101 947 dbSNP
rs773235320 950 dbSNP
rs1213821459 951 dbSNP
rs760764179 952 dbSNP
rs1305209740 953 dbSNP
rs770965097 954 dbSNP
rs1438031252 961 dbSNP
rs1381920013 964 dbSNP
rs777163691 965 dbSNP
rs1000695171 968 dbSNP
rs576204797 969 dbSNP
rs1393102644 972 dbSNP
rs376244868 978 dbSNP
rs1033130499 980 dbSNP
rs371369320 981 dbSNP
rs201016490 982 dbSNP
rs1395875602 986 dbSNP
rs763797471 990 dbSNP
rs1239169905 997 dbSNP
rs1485982474 1000 dbSNP
rs377744792 1000 dbSNP
rs370991481 1002 dbSNP
rs1363761350 1003 dbSNP
rs898099345 1010 dbSNP
rs555640575 1013 dbSNP
rs1481555394 1038 dbSNP
rs572293434 1052 dbSNP
rs972271626 1053 dbSNP
rs1158115049 1054 dbSNP
rs185050606 1058 dbSNP
rs1231643677 1060 dbSNP
rs1369865814 1075 dbSNP
rs1307080070 1078 dbSNP
rs1421504323 1082 dbSNP
rs564100997 1085 dbSNP
rs1296990989 1087 dbSNP
rs1363835822 1088 dbSNP
rs878962503 1090 dbSNP
rs1429436695 1091 dbSNP
rs34924932 1095 dbSNP
rs751191584 1102 dbSNP
rs1275461850 1103 dbSNP
rs1370041861 1122 dbSNP
rs577798488 1126 dbSNP
rs930834236 1136 dbSNP
rs1377319569 1137 dbSNP
rs971418363 1140 dbSNP
rs1420984047 1143 dbSNP
rs1248280605 1146 dbSNP
rs1181375858 1148 dbSNP
rs985363111 1151 dbSNP
rs1003321407 1152 dbSNP
rs757085140 1167 dbSNP
rs1282184208 1172 dbSNP
rs1034933044 1180 dbSNP
rs956863137 1189 dbSNP
rs988039210 1209 dbSNP
rs915047252 1210 dbSNP
rs780926735 1213 dbSNP
rs1286937314 1220 dbSNP
rs1409733743 1222 dbSNP
rs1219516613 1223 dbSNP
rs1315136800 1226 dbSNP
rs1413371829 1231 dbSNP
rs148354109 1232 dbSNP
rs942432714 1237 dbSNP
rs1455354216 1242 dbSNP
rs375968934 1245 dbSNP
rs1158598625 1246 dbSNP
rs1039382398 1251 dbSNP
rs1259580425 1253 dbSNP
rs900821284 1261 dbSNP
rs933910778 1269 dbSNP
rs1040466304 1272 dbSNP
rs918947402 1272 dbSNP
rs750351395 1279 dbSNP
rs1348169887 1284 dbSNP
rs188212454 1284 dbSNP
rs1247883609 1285 dbSNP
rs1468296544 1286 dbSNP
rs1176256170 1287 dbSNP
rs1380757386 1288 dbSNP
rs1233407284 1289 dbSNP
rs1441283750 1289 dbSNP
rs1295675484 1293 dbSNP
rs903099593 1295 dbSNP
rs756019604 1306 dbSNP
rs1033241504 1309 dbSNP
rs887904190 1312 dbSNP
rs181082480 1316 dbSNP
rs1383163279 1321 dbSNP
rs1319937179 1323 dbSNP
rs1462078593 1324 dbSNP
rs1419889684 1325 dbSNP
rs1162708565 1328 dbSNP
rs1364910235 1329 dbSNP
rs531937558 1331 dbSNP
rs894587501 1332 dbSNP
rs1247079227 1334 dbSNP
rs781359087 1340 dbSNP
rs1024314155 1354 dbSNP
rs1275528538 1356 dbSNP
rs971355217 1357 dbSNP
rs1230129118 1358 dbSNP
rs1297172800 1359 dbSNP
rs1396802672 1359 dbSNP
rs1009406547 1360 dbSNP
rs1174095273 1360 dbSNP
rs1190101343 1360 dbSNP
rs1233927049 1360 dbSNP
rs1273117911 1360 dbSNP
rs1330845922 1360 dbSNP
rs1336222697 1360 dbSNP
rs1369736373 1360 dbSNP
rs1422671490 1360 dbSNP
rs1427512089 1360 dbSNP
rs1435906522 1360 dbSNP
rs1436198744 1360 dbSNP
rs369374116 1360 dbSNP
rs71165635 1360 dbSNP
rs759450812 1360 dbSNP
rs769806796 1360 dbSNP
rs972052323 1360 dbSNP
rs1022171993 1361 dbSNP
rs1184616594 1361 dbSNP
rs1026608307 1362 dbSNP
rs1351631136 1363 dbSNP
rs1440363891 1364 dbSNP
rs967853581 1364 dbSNP
rs1350291795 1366 dbSNP
rs1276795469 1368 dbSNP
rs1218677556 1372 dbSNP
rs1351496284 1374 dbSNP
rs548559805 1376 dbSNP
rs985955306 1378 dbSNP
rs1378159300 1380 dbSNP
rs910283422 1382 dbSNP
rs1313229898 1384 dbSNP
rs966161652 1386 dbSNP
rs1174954741 1388 dbSNP
rs1357024725 1388 dbSNP
rs1359362417 1388 dbSNP
rs1229338462 1390 dbSNP
rs1400724644 1390 dbSNP
rs1156405286 1392 dbSNP
rs1438954605 1392 dbSNP
rs1471878529 1392 dbSNP
rs1189029868 1394 dbSNP
rs755853924 1394 dbSNP
rs1235876992 1395 dbSNP
rs1209703608 1396 dbSNP
rs61483260 1396 dbSNP
rs766234264 1396 dbSNP
rs867413345 1396 dbSNP
rs985007747 1396 dbSNP
rs1260632 1398 dbSNP
rs1491413946 1398 dbSNP
rs867656959 1398 dbSNP
rs74404860 1400 dbSNP
rs1203430258 1402 dbSNP
rs1238385582 1404 dbSNP
rs1458782037 1410 dbSNP
rs1234863968 1413 dbSNP
rs1181557964 1414 dbSNP
rs1376708874 1419 dbSNP
rs749435541 1419 dbSNP
rs1384307289 1429 dbSNP
rs1473092809 1434 dbSNP
rs879610291 1437 dbSNP
rs1164913451 1438 dbSNP
rs918881276 1439 dbSNP
rs1408244253 1445 dbSNP
rs1317931145 1446 dbSNP
rs1456267166 1449 dbSNP
rs963844286 1459 dbSNP
rs562403237 1460 dbSNP
rs528006021 1461 dbSNP
rs1049337404 1463 dbSNP
rs922278345 1464 dbSNP
rs933691330 1465 dbSNP
rs1041361544 1466 dbSNP
rs1250192155 1475 dbSNP
rs1464527699 1480 dbSNP
rs1273663949 1485 dbSNP
rs1215467830 1503 dbSNP
rs1319922758 1508 dbSNP
rs542847751 1513 dbSNP
rs532950754 1515 dbSNP
rs907388773 1519 dbSNP
rs1003342651 1523 dbSNP
rs11548915 1528 dbSNP
rs1294982013 1532 dbSNP
rs547370765 1538 dbSNP
rs935903689 1554 dbSNP
rs1394593725 1557 dbSNP
rs1327402415 1569 dbSNP
rs1449494030 1569 dbSNP
rs1199585326 1572 dbSNP
rs1459896554 1578 dbSNP
rs1054314214 1582 dbSNP
rs1286439533 1604 dbSNP
rs1044041 1608 dbSNP
rs1213503830 1630 dbSNP
rs186503887 1633 dbSNP
rs1392214530 1643 dbSNP
rs551677447 1659 dbSNP
rs1319561159 1662 dbSNP
rs1448881303 1671 dbSNP
rs1201323715 1682 dbSNP
rs894262039 1683 dbSNP
rs1193030362 1688 dbSNP
rs1487452078 1690 dbSNP
rs778002883 1694 dbSNP
rs1013012309 1698 dbSNP
rs1045884589 1700 dbSNP
rs907285833 1701 dbSNP
rs1204903356 1706 dbSNP
rs35936804 1712 dbSNP
rs891759450 1721 dbSNP
rs583121 1723 dbSNP
rs1227191632 1740 dbSNP
rs117293194 1741 dbSNP
rs1304955913 1743 dbSNP
rs1022160763 1746 dbSNP
rs1026307870 1748 dbSNP
rs1366052216 1750 dbSNP
rs377558037 1755 dbSNP
rs745494482 1761 dbSNP
rs1170095070 1767 dbSNP
rs965913695 1771 dbSNP
rs1424359105 1776 dbSNP
rs976195277 1782 dbSNP
rs1395971814 1789 dbSNP
rs1467436623 1790 dbSNP
rs1174544692 1796 dbSNP
rs1178264054 1799 dbSNP
rs1431538363 1799 dbSNP
rs1017772400 1810 dbSNP
rs1266500780 1814 dbSNP
rs1177722225 1837 dbSNP
rs550250174 1841 dbSNP
rs569709129 1842 dbSNP
rs535626474 1866 dbSNP
rs1348132906 1871 dbSNP
rs1325233326 1879 dbSNP
rs1257420924 1881 dbSNP
rs1399863499 1883 dbSNP
rs1311109456 1886 dbSNP
rs769356409 1894 dbSNP
rs955106262 1895 dbSNP
rs1352905859 1904 dbSNP
rs1306533363 1905 dbSNP
rs57512913 1912 dbSNP
rs1221377019 1913 dbSNP
rs200210578 1914 dbSNP
rs534952797 1915 dbSNP
rs557754734 1927 dbSNP
rs1377122879 1930 dbSNP
rs1160005580 1936 dbSNP
rs577737442 1940 dbSNP
rs1446358195 1952 dbSNP
rs1054746489 1956 dbSNP
rs566965148 1957 dbSNP
rs1264083035 1961 dbSNP
rs938866113 1962 dbSNP
rs915823069 1964 dbSNP
rs1181133621 1967 dbSNP
rs1257754870 1968 dbSNP
rs1485896725 1968 dbSNP
rs948575026 1969 dbSNP
rs1260768967 1971 dbSNP
rs569805326 1971 dbSNP
rs1053611656 1973 dbSNP
rs543497143 1979 dbSNP
rs1287036941 1984 dbSNP
rs1045573433 1990 dbSNP
rs1228092063 1992 dbSNP
rs907317009 1998 dbSNP
rs537453667 2002 dbSNP
rs947370826 2003 dbSNP
rs1043014909 2020 dbSNP
rs189418048 2029 dbSNP
rs74177123 2037 dbSNP
rs78363788 2037 dbSNP
rs72080999 2038 dbSNP
rs1386317998 2039 dbSNP
rs748020470 2046 dbSNP
rs1485577113 2048 dbSNP
rs1007855128 2052 dbSNP
rs1017521405 2055 dbSNP
rs1185232452 2056 dbSNP
rs887733630 2059 dbSNP
rs901668105 2063 dbSNP
rs1006479491 2064 dbSNP
rs1210012200 2069 dbSNP
rs1463164274 2071 dbSNP
rs79504017 2073 dbSNP
rs1208632421 2077 dbSNP
rs1357754302 2079 dbSNP
rs1286287783 2083 dbSNP
rs773659631 2084 dbSNP
rs761094147 2089 dbSNP
rs1402526179 2101 dbSNP
rs566440081 2107 dbSNP
rs1298654076 2115 dbSNP
rs964986457 2116 dbSNP
rs140534397 2117 dbSNP
rs1277617428 2124 dbSNP
rs980723375 2125 dbSNP
rs562177646 2127 dbSNP
rs1217302161 2137 dbSNP
rs16427 2138 dbSNP
rs377341187 2138 dbSNP
rs796930609 2138 dbSNP
rs1489825901 2139 dbSNP
rs1161190604 2141 dbSNP
rs868746268 2141 dbSNP
rs955138781 2142 dbSNP
rs200994564 2143 dbSNP
rs1208167213 2149 dbSNP
rs562720333 2152 dbSNP
rs1447341852 2153 dbSNP
rs1246876259 2163 dbSNP
rs547704221 2183 dbSNP
rs1031344275 2188 dbSNP
rs1452673798 2190 dbSNP
rs1043130142 2191 dbSNP
rs1452421564 2202 dbSNP
rs911181895 2209 dbSNP
rs1356101955 2211 dbSNP
rs957297825 2221 dbSNP
rs1044053 2226 dbSNP
rs1275548737 2232 dbSNP
rs989830800 2238 dbSNP
rs1230869414 2239 dbSNP
rs1340386671 2241 dbSNP
rs1296929858 2243 dbSNP
rs1201264104 2246 dbSNP
rs1437308340 2248 dbSNP
rs1332715351 2252 dbSNP
rs762577021 2259 dbSNP
rs1362489546 2261 dbSNP
rs1385954991 2262 dbSNP
rs866915119 2263 dbSNP
rs181371611 2271 dbSNP
rs1439435859 2273 dbSNP
rs1170324615 2277 dbSNP
rs1427385764 2287 dbSNP
rs185744368 2294 dbSNP
rs1173665645 2307 dbSNP
rs1478744612 2309 dbSNP
rs1248898288 2320 dbSNP
rs1039353674 2322 dbSNP
rs549946139 2331 dbSNP
rs531527096 2335 dbSNP
rs570134386 2340 dbSNP
rs997738831 2342 dbSNP
rs1340276934 2343 dbSNP
rs1274228047 2353 dbSNP
rs928431904 2357 dbSNP
rs1347234327 2360 dbSNP
rs929376420 2365 dbSNP
rs1048239318 2367 dbSNP
rs1351073125 2374 dbSNP
rs1309596416 2379 dbSNP
rs1001184384 2386 dbSNP
rs1369515352 2389 dbSNP
rs1390747210 2395 dbSNP
rs1388222811 2397 dbSNP
rs1005942942 2402 dbSNP
rs763564797 2404 dbSNP
rs751244497 2410 dbSNP
rs942064110 2421 dbSNP
rs1413411777 2425 dbSNP
rs529399905 2425 dbSNP
rs1039015181 2436 dbSNP
rs1036341065 2438 dbSNP
rs190553073 2448 dbSNP
rs1251277479 2449 dbSNP
rs183176239 2455 dbSNP
rs989479943 2456 dbSNP
rs913367828 2461 dbSNP
rs1264997790 2462 dbSNP
rs1276552183 2465 dbSNP
rs1199990469 2471 dbSNP
rs1030474881 2472 dbSNP
rs1329719823 2489 dbSNP
rs1290173708 2492 dbSNP
rs534889462 2505 dbSNP
rs1226276247 2507 dbSNP
rs1349667020 2508 dbSNP
rs1284626981 2512 dbSNP
rs1488845358 2516 dbSNP
rs902655976 2526 dbSNP
rs1449772774 2532 dbSNP
rs1332907704 2542 dbSNP
rs1357111538 2542 dbSNP
rs1211898802 2548 dbSNP
rs1389932244 2548 dbSNP
rs1162014592 2556 dbSNP
rs558088603 2575 dbSNP
rs571223159 2582 dbSNP
rs1182844420 2587 dbSNP
rs978810887 2589 dbSNP
rs1235966594 2602 dbSNP
rs1209461392 2613 dbSNP
rs535150008 2615 dbSNP
rs1031878763 2618 dbSNP
rs1206729250 2619 dbSNP
rs911339066 2622 dbSNP
rs1290294915 2624 dbSNP
rs1229872821 2625 dbSNP
rs537041546 2627 dbSNP
rs761407444 2628 dbSNP
rs1435114779 2637 dbSNP
rs1366721465 2642 dbSNP
rs1443338359 2644 dbSNP
rs942680185 2651 dbSNP
rs1345168634 2652 dbSNP
rs556710365 2653 dbSNP
rs573664097 2654 dbSNP
rs1022602708 2657 dbSNP
rs1368584965 2659 dbSNP
rs969983644 2666 dbSNP
rs1458976899 2668 dbSNP
rs922613393 2669 dbSNP
rs1183238985 2671 dbSNP
rs1450388757 2673 dbSNP
rs1249977110 2675 dbSNP
rs1186804633 2676 dbSNP
rs1485492337 2684 dbSNP
rs981318845 2687 dbSNP
rs1399133994 2690 dbSNP
rs542372212 2692 dbSNP
rs1047687844 2694 dbSNP
rs1288947363 2697 dbSNP
rs886233690 2707 dbSNP
rs1343908251 2708 dbSNP
rs1294736588 2709 dbSNP
rs553487663 2718 dbSNP
rs774263459 2719 dbSNP
rs1395449879 2725 dbSNP
rs572306587 2731 dbSNP
rs541284100 2734 dbSNP
rs905642644 2735 dbSNP
rs983299621 2738 dbSNP
rs1348487484 2743 dbSNP
rs150330390 2748 dbSNP
rs1163421071 2750 dbSNP
rs1001590790 2751 dbSNP
rs909311321 2752 dbSNP
rs1166745824 2753 dbSNP
rs1428031365 2755 dbSNP
rs1192832841 2756 dbSNP
rs1322454064 2757 dbSNP
rs1205668209 2759 dbSNP
rs28733792 2759 dbSNP
rs1483803606 2761 dbSNP
rs1272078691 2762 dbSNP
rs1226936508 2778 dbSNP
rs1312282312 2779 dbSNP
rs942112988 2780 dbSNP
rs959980070 2783 dbSNP
rs1010402679 2787 dbSNP
rs1039459032 2793 dbSNP
rs750164718 2797 dbSNP
rs533489951 2800 dbSNP
rs7248629 2804 dbSNP
rs1199438387 2827 dbSNP
rs1461723055 2828 dbSNP
rs1378270882 2831 dbSNP
rs1260454416 2843 dbSNP
rs755856165 2844 dbSNP
rs1052000967 2845 dbSNP
rs1431346084 2845 dbSNP
rs902770803 2854 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb HITS-CLIP data was present in GSM1084081. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SantaCruzAb HITS-CLIP data was present in GSM1084083. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_SigmaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_015578 | 3UTR | UUAACAAGUAUUUUUUCAUCACUGAAAGGUUUUUUUUUUUUAUCACUAAAUUGUAUUUGGCAAUUGCAAGUUGCCUGCAGAUAGGGCCGUGAUACUGUGUUUUGAGCCACAGAAGGUUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUGUAUGUGUGUGUCUUUUUCCUCCUUUCUUUUGGGGAAUCCUGUAAUAUGAGGUAGCUUAUUUCGUCAAUUAAUUAGGGUGCUGGAUGGUAGAGAAUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000433627.5 | 3UTR | GAAAGGUUUUUUUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000433627.5 | 3UTR | GAAAGGUUUUUUUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1084081
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SantaCruzAb
Location of target site ENST00000433627.5 | 3UTR | AAAGGUUUUUUUUUUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM1084083
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_SigmaAb
Location of target site ENST00000433627.5 | 3UTR | AAAGGUUUUUUUUUUUUAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
275 hsa-miR-548ac Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT055863 BUB3 BUB3, mitotic checkpoint protein 2 2
MIRT074959 LEPROT leptin receptor overlapping transcript 2 2
MIRT076823 SUZ12 SUZ12 polycomb repressive complex 2 subunit 2 4
MIRT078708 LLGL2 LLGL2, scribble cell polarity complex component 2 2
MIRT099610 ID4 inhibitor of DNA binding 4, HLH protein 2 4
MIRT103362 CBX3 chromobox 3 2 2
MIRT111801 MPZL1 myelin protein zero like 1 2 2
MIRT114050 AKAP11 A-kinase anchoring protein 11 2 12
MIRT133719 SKI SKI proto-oncogene 2 2
MIRT136817 NHLRC3 NHL repeat containing 3 2 6
MIRT149926 LDLR low density lipoprotein receptor 2 2
MIRT166915 TNPO1 transportin 1 2 2
MIRT168142 SOX4 SRY-box 4 2 10
MIRT190787 STRN3 striatin 3 2 4
MIRT207471 RMND5A required for meiotic nuclear division 5 homolog A 2 2
MIRT250951 CDK5R1 cyclin dependent kinase 5 regulatory subunit 1 2 4
MIRT271993 ARF1 ADP ribosylation factor 1 2 4
MIRT282618 IGF1R insulin like growth factor 1 receptor 2 8
MIRT294153 ZNF845 zinc finger protein 845 2 2
MIRT309060 C4ORF3 chromosome 4 open reading frame 3 2 2
MIRT318548 SYNCRIP synaptotagmin binding cytoplasmic RNA interacting protein 2 2
MIRT319752 LUC7L2 LUC7 like 2, pre-mRNA splicing factor 2 2
MIRT331324 TM9SF3 transmembrane 9 superfamily member 3 2 2
MIRT337204 TOMM20 translocase of outer mitochondrial membrane 20 2 6
MIRT346145 ALYREF Aly/REF export factor 2 2
MIRT347727 LSM14A LSM14A, mRNA processing body assembly factor 2 2
MIRT350503 MRGBP MRG domain binding protein 2 6
MIRT356409 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 2
MIRT357986 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT374399 M6PR mannose-6-phosphate receptor, cation dependent 2 6
MIRT442727 TMEM158 transmembrane protein 158 (gene/pseudogene) 2 2
MIRT443411 HMX3 H6 family homeobox 3 2 2
MIRT444408 FRMD5 FERM domain containing 5 2 2
MIRT444469 PTPRG protein tyrosine phosphatase, receptor type G 2 2
MIRT444650 HSBP1 heat shock factor binding protein 1 2 2
MIRT444861 EXD2 exonuclease 3'-5' domain containing 2 2 2
MIRT445685 TNFSF15 TNF superfamily member 15 2 2
MIRT446001 CD1D CD1d molecule 2 2
MIRT446074 RABIF RAB interacting factor 2 2
MIRT446308 ACSL3 acyl-CoA synthetase long chain family member 3 2 2
MIRT446432 ABHD2 abhydrolase domain containing 2 2 2
MIRT447269 C3orf30 chromosome 3 open reading frame 30 2 2
MIRT447759 TMCC3 transmembrane and coiled-coil domain family 3 2 2
MIRT448161 P2RY10 purinergic receptor P2Y10 2 2
MIRT449049 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 2 2
MIRT449275 PALM2 paralemmin 2 2 2
MIRT450122 IMP3 IMP3, U3 small nucleolar ribonucleoprotein 2 2
MIRT450155 GABRB3 gamma-aminobutyric acid type A receptor beta3 subunit 2 2
MIRT451289 ZNF101 zinc finger protein 101 2 2
MIRT459253 ADRBK1 G protein-coupled receptor kinase 2 2 2
MIRT462554 NUDT19 nudix hydrolase 19 2 2
MIRT464470 UGCG UDP-glucose ceramide glucosyltransferase 2 2
MIRT465120 TSC22D2 TSC22 domain family member 2 2 4
MIRT467996 SKIL SKI like proto-oncogene 2 2
MIRT468718 SDC4 syndecan 4 2 2
MIRT469269 RHOB ras homolog family member B 2 2
MIRT470675 POLR2D RNA polymerase II subunit D 2 4
MIRT470723 POGK pogo transposable element derived with KRAB domain 2 2
MIRT471438 PDIA6 protein disulfide isomerase family A member 6 2 2
MIRT471502 PDE4D phosphodiesterase 4D 2 4
MIRT471988 NR2F2 nuclear receptor subfamily 2 group F member 2 2 4
MIRT472386 NEK7 NIMA related kinase 7 2 2
MIRT475028 KANSL1 KAT8 regulatory NSL complex subunit 1 2 8
MIRT479411 CDKN1B cyclin dependent kinase inhibitor 1B 2 10
MIRT480514 C11orf57 chromosome 11 open reading frame 57 2 2
MIRT481700 AR androgen receptor 2 2
MIRT482543 ACTB actin beta 2 4
MIRT482627 ABCE1 ATP binding cassette subfamily E member 1 2 2
MIRT484725 INHBA inhibin beta A subunit 2 12
MIRT487778 ANKEF1 ankyrin repeat and EF-hand domain containing 1 2 16
MIRT491883 YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 2 2
MIRT494653 ARNTL aryl hydrocarbon receptor nuclear translocator like 2 2
MIRT497366 SF1 splicing factor 1 2 2
MIRT499156 HSPA1B heat shock protein family A (Hsp70) member 1B 2 8
MIRT502830 CELSR3 cadherin EGF LAG seven-pass G-type receptor 3 2 6
MIRT502944 CDC37L1 cell division cycle 37 like 1 2 8
MIRT503942 FBXL13 F-box and leucine rich repeat protein 13 2 4
MIRT504235 MYO6 myosin VI 2 2
MIRT504453 MC2R melanocortin 2 receptor 2 2
MIRT506022 PURA purine rich element binding protein A 2 2
MIRT508028 BCAT1 branched chain amino acid transaminase 1 2 4
MIRT508299 YES1 YES proto-oncogene 1, Src family tyrosine kinase 2 4
MIRT511515 HMGN2 high mobility group nucleosomal binding domain 2 2 2
MIRT512307 AMER1 APC membrane recruitment protein 1 2 6
MIRT514565 XRCC3 X-ray repair cross complementing 3 2 4
MIRT515657 MYBPC1 myosin binding protein C, slow type 2 2
MIRT518429 SSU72 SSU72 homolog, RNA polymerase II CTD phosphatase 2 2
MIRT520378 UBE2D1 ubiquitin conjugating enzyme E2 D1 2 4
MIRT521604 PSMA2 proteasome subunit alpha 2 2 4
MIRT521725 PPP3R1 protein phosphatase 3 regulatory subunit B, alpha 2 4
MIRT522579 MBNL3 muscleblind like splicing regulator 3 2 4
MIRT522731 LRRC55 leucine rich repeat containing 55 2 8
MIRT524547 CDC5L cell division cycle 5 like 2 4
MIRT525371 SYNM synemin 2 2
MIRT526489 PPIA peptidylprolyl isomerase A 2 4
MIRT527197 CLASP1 cytoplasmic linker associated protein 1 2 2
MIRT527285 FBLN2 fibulin 2 2 2
MIRT527383 MGARP mitochondria localized glutamic acid rich protein 2 2
MIRT527409 SMU1 DNA replication regulator and spliceosomal factor 2 6
MIRT527454 COL4A3 collagen type IV alpha 3 chain 2 2
MIRT528348 TBC1D22B TBC1 domain family member 22B 2 2
MIRT529104 ZNF100 zinc finger protein 100 2 2
MIRT529317 ATRNL1 attractin like 1 2 2
MIRT529328 PDE5A phosphodiesterase 5A 2 2
MIRT529750 SEL1L SEL1L ERAD E3 ligase adaptor subunit 2 2
MIRT530277 MKRN3 makorin ring finger protein 3 2 2
MIRT531415 TMEM18 transmembrane protein 18 2 2
MIRT532544 WDR13 WD repeat domain 13 2 2
MIRT533245 VKORC1L1 vitamin K epoxide reductase complex subunit 1 like 1 2 2
MIRT534659 RNF20 ring finger protein 20 2 2
MIRT534818 RAB33B RAB33B, member RAS oncogene family 2 2
MIRT537492 FAM169A family with sequence similarity 169 member A 2 2
MIRT538778 CABLES1 Cdk5 and Abl enzyme substrate 1 2 2
MIRT539122 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT540964 SLC25A43 solute carrier family 25 member 43 2 2
MIRT541403 CDC27 cell division cycle 27 2 2
MIRT543353 ZNF829 zinc finger protein 829 2 2
MIRT543623 MFAP3 microfibril associated protein 3 2 2
MIRT543649 YY2 YY2 transcription factor 2 2
MIRT544945 SNCB synuclein beta 2 2
MIRT545327 SPC25 SPC25, NDC80 kinetochore complex component 2 2
MIRT546094 VEZF1 vascular endothelial zinc finger 1 2 2
MIRT548605 DCUN1D3 defective in cullin neddylation 1 domain containing 3 2 2
MIRT548638 DAZAP1 DAZ associated protein 1 2 4
MIRT550318 ZNF681 zinc finger protein 681 2 2
MIRT550412 SLC29A1 solute carrier family 29 member 1 (Augustine blood group) 2 4
MIRT551034 SPPL3 signal peptide peptidase like 3 2 2
MIRT551602 HDGFRP2 HDGF like 2 2 2
MIRT552064 ALG1 ALG1, chitobiosyldiphosphodolichol beta-mannosyltransferase 2 4
MIRT552803 YAF2 YY1 associated factor 2 2 2
MIRT553274 TVP23C trans-golgi network vesicle protein 23 homolog C 2 2
MIRT553303 TSPAN3 tetraspanin 3 2 2
MIRT553570 NPM3 nucleophosmin/nucleoplasmin 3 2 2
MIRT554844 RECK reversion inducing cysteine rich protein with kazal motifs 2 2
MIRT556069 MTF2 metal response element binding transcription factor 2 2 4
MIRT556898 ITGA2 integrin subunit alpha 2 2 2
MIRT558680 CNIH cornichon family AMPA receptor auxiliary protein 1 1 1
MIRT559032 C20orf24 chromosome 20 open reading frame 24 2 2
MIRT559108 C18orf25 chromosome 18 open reading frame 25 2 2
MIRT559864 GSKIP GSK3B interacting protein 2 2
MIRT560868 GAL3ST3 galactose-3-O-sulfotransferase 3 2 2
MIRT562268 GRB2 growth factor receptor bound protein 2 2 2
MIRT562419 EIF2S2 eukaryotic translation initiation factor 2 subunit beta 2 2
MIRT562652 ARID1A AT-rich interaction domain 1A 2 4
MIRT563771 ZNF678 zinc finger protein 678 2 2
MIRT564279 DEPDC1B DEP domain containing 1B 2 2
MIRT565253 TRA2B transformer 2 beta homolog 2 4
MIRT565307 TMEM64 transmembrane protein 64 2 2
MIRT566034 RFX1 regulatory factor X1 2 2
MIRT566714 MTMR3 myotubularin related protein 3 2 2
MIRT568087 CELF2 CUGBP Elav-like family member 2 2 2
MIRT568417 ATF7IP activating transcription factor 7 interacting protein 2 2
MIRT568766 MYBL1 MYB proto-oncogene like 1 2 2
MIRT569516 THYN1 thymocyte nuclear protein 1 2 2
MIRT571823 PHF19 PHD finger protein 19 2 2
MIRT571995 HOXA9 homeobox A9 2 2
MIRT572174 CELF1 CUGBP Elav-like family member 1 2 2
MIRT572637 ACOT9 acyl-CoA thioesterase 9 2 2
MIRT573756 KHSRP KH-type splicing regulatory protein 2 2
MIRT574089 CCDC132 VPS50, EARP/GARPII complex subunit 2 6
MIRT574311 CMTM6 CKLF like MARVEL transmembrane domain containing 6 2 2
MIRT574512 PSAT1 phosphoserine aminotransferase 1 2 2
MIRT574559 NRBF2 nuclear receptor binding factor 2 2 2
MIRT576686 H6pd hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase) 2 2
MIRT608491 NKTR natural killer cell triggering receptor 2 6
MIRT608640 ATP9A ATPase phospholipid transporting 9A (putative) 2 6
MIRT609231 TMEM189 transmembrane protein 189 2 2
MIRT609561 TCEAL4 transcription elongation factor A like 4 2 2
MIRT610193 FAM49A family with sequence similarity 49 member A 2 2
MIRT610681 SYT2 synaptotagmin 2 2 4
MIRT610725 NAV2 neuron navigator 2 2 2
MIRT610813 SGOL2 shugoshin 2 2 2
MIRT610993 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT611030 KCNK10 potassium two pore domain channel subfamily K member 10 2 2
MIRT611339 SLC2A4 solute carrier family 2 member 4 2 2
MIRT611511 HIPK3 homeodomain interacting protein kinase 3 2 2
MIRT611638 EDIL3 EGF like repeats and discoidin domains 3 2 2
MIRT611856 RPL3L ribosomal protein L3 like 2 2
MIRT611905 TRPC3 transient receptor potential cation channel subfamily C member 3 2 2
MIRT612047 PCNXL2 pecanex homolog 2 2 6
MIRT612340 TRIB2 tribbles pseudokinase 2 2 2
MIRT612870 INO80C INO80 complex subunit C 2 2
MIRT613555 AMPD3 adenosine monophosphate deaminase 3 2 2
MIRT614490 MMS22L MMS22 like, DNA repair protein 2 2
MIRT615098 BRD4 bromodomain containing 4 2 2
MIRT616228 PTPN11 protein tyrosine phosphatase, non-receptor type 11 2 2
MIRT617220 GDPGP1 GDP-D-glucose phosphorylase 1 2 2
MIRT617884 ESR1 estrogen receptor 1 2 2
MIRT618344 CD59 CD59 molecule (CD59 blood group) 2 2
MIRT620264 RAPH1 Ras association (RalGDS/AF-6) and pleckstrin homology domains 1 2 2
MIRT620660 CCDC108 cilia and flagella associated protein 65 2 2
MIRT620761 CCR5 C-C motif chemokine receptor 5 (gene/pseudogene) 2 2
MIRT621416 TXNL1 thioredoxin like 1 2 2
MIRT621676 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT622231 SLC25A51 solute carrier family 25 member 51 2 2
MIRT622377 SALL1 spalt like transcription factor 1 2 2
MIRT622404 RRAGC Ras related GTP binding C 2 2
MIRT622494 RC3H1 ring finger and CCCH-type domains 1 2 2
MIRT623064 NRXN1 neurexin 1 2 2
MIRT623295 MAX MYC associated factor X 2 2
MIRT623691 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT623930 FMNL3 formin like 3 2 2
MIRT623984 FAM208A family with sequence similarity 208 member A 2 2
MIRT624513 C7orf55-LUC7L2 C7orf55-LUC7L2 readthrough 2 2
MIRT624668 ARID4A AT-rich interaction domain 4A 2 2
MIRT624756 ANGPTL2 angiopoietin like 2 2 2
MIRT624949 MARCH2 membrane associated ring-CH-type finger 2 2 2
MIRT625968 RNF2 ring finger protein 2 2 2
MIRT626415 KIAA2018 upstream transcription factor family member 3 2 2
MIRT626882 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
MIRT627157 ZNF652 zinc finger protein 652 2 2
MIRT627613 SFT2D2 SFT2 domain containing 2 2 2
MIRT627744 RAP2B RAP2B, member of RAS oncogene family 2 4
MIRT627808 PTEN phosphatase and tensin homolog 2 2
MIRT627820 PRR3 proline rich 3 2 2
MIRT630935 UNC93A unc-93 homolog A 2 2
MIRT635930 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT638301 SERBP1 SERPINE1 mRNA binding protein 1 2 2
MIRT638437 PNRC1 proline rich nuclear receptor coactivator 1 2 2
MIRT640281 TCF24 transcription factor 24 2 2
MIRT641979 PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2 2
MIRT644179 GIN1 gypsy retrotransposon integrase 1 2 2
MIRT644439 VDR vitamin D receptor 2 2
MIRT644974 STEAP4 STEAP4 metalloreductase 2 2
MIRT647653 B3GALNT1 beta-1,3-N-acetylgalactosaminyltransferase 1 (globoside blood group) 2 2
MIRT648702 TNFRSF13C TNF receptor superfamily member 13C 2 2
MIRT650120 ZCCHC9 zinc finger CCHC-type containing 9 2 2
MIRT650505 UFM1 ubiquitin fold modifier 1 2 2
MIRT650701 CLNK cytokine dependent hematopoietic cell linker 2 2
MIRT651083 ZNF518B zinc finger protein 518B 2 4
MIRT653644 SLC30A1 solute carrier family 30 member 1 2 2
MIRT653788 SIX4 SIX homeobox 4 2 2
MIRT656773 LCOR ligand dependent nuclear receptor corepressor 2 2
MIRT656949 KIAA1456 KIAA1456 2 2
MIRT656981 KDM5A lysine demethylase 5A 2 2
MIRT657225 TOR1AIP2 torsin 1A interacting protein 2 2 4
MIRT657706 GPC5 glypican 5 2 2
MIRT660107 BTBD3 BTB domain containing 3 2 2
MIRT662817 C9orf64 chromosome 9 open reading frame 64 2 2
MIRT665889 TGIF2 TGFB induced factor homeobox 2 2 2
MIRT668140 GINS2 GINS complex subunit 2 2 2
MIRT668566 ERCC1 ERCC excision repair 1, endonuclease non-catalytic subunit 2 2
MIRT669718 AAGAB alpha and gamma adaptin binding protein 2 2
MIRT685693 TRIM45 tripartite motif containing 45 2 2
MIRT686579 TMPPE transmembrane protein with metallophosphoesterase domain 2 2
MIRT687491 NHLRC2 NHL repeat containing 2 2 2
MIRT687805 KCNJ15 potassium voltage-gated channel subfamily J member 15 2 2
MIRT687968 HHIP hedgehog interacting protein 2 2
MIRT689487 SCIMP SLP adaptor and CSK interacting membrane protein 2 2
MIRT689595 NUDT7 nudix hydrolase 7 2 2
MIRT690501 RSRC1 arginine and serine rich coiled-coil 1 2 2
MIRT692290 XRN2 5'-3' exoribonuclease 2 2 2
MIRT693060 KIAA1324 KIAA1324 2 2
MIRT697443 ZFHX3 zinc finger homeobox 3 2 2
MIRT698475 TJP1 tight junction protein 1 2 2
MIRT699033 SOAT1 sterol O-acyltransferase 1 2 2
MIRT699785 SEMA4D semaphorin 4D 2 2
MIRT701463 NEO1 neogenin 1 2 2
MIRT701869 MRO maestro 2 2
MIRT702158 MAP3K1 mitogen-activated protein kinase kinase kinase 1 2 2
MIRT703750 FAM126B family with sequence similarity 126 member B 2 2
MIRT704277 DGS2 DiGeorge syndrome/velocardiofacial syndrome complex 2 2 2
MIRT707956 PGM3 phosphoglucomutase 3 2 2
MIRT712747 LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 2 2
MIRT712848 RHOA ras homolog family member A 2 2
MIRT712954 CCBE1 collagen and calcium binding EGF domains 1 2 2
MIRT713119 U2SURP U2 snRNP associated SURP domain containing 2 2
MIRT713148 PKIA cAMP-dependent protein kinase inhibitor alpha 2 2
MIRT715394 TADA3 transcriptional adaptor 3 2 2
MIRT715475 NEGR1 neuronal growth regulator 1 2 2
MIRT715535 G2E3 G2/M-phase specific E3 ubiquitin protein ligase 2 2
MIRT721159 MYOCD myocardin 2 2
MIRT722719 ZNF460 zinc finger protein 460 2 2
MIRT723130 GTF2F2 general transcription factor IIF subunit 2 2 2
MIRT723259 TMLHE trimethyllysine hydroxylase, epsilon 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-54 Nicotine approved 89594 Microarray Caenorhabditis elegans 23765240 2013 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-548ac Cisplatin 5460033 NSC119875 approved sensitive cell line (BxPC3)
hsa-miR-548ac Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-548ac Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-548ac Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-548ac Paclitaxel 36314 NSC125973 approved sensitive cell line (HS578T)
hsa-miR-548ac Paclitaxel 36314 NSC125973 approved resistant cell line (BAS)
hsa-miR-548ac Doxorubicin 31703 NSC123127 approved resistant cell line (BAS)
hsa-miR-548ac Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-548ac Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-548ac Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)

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