miRTarBase - #MIRT349266


—
pre-miRNA Information
pre-miRNA hsa-mir-4457   
Genomic Coordinates chr5: 1309310 - 1309377
Description Homo sapiens miR-4457 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4457
Sequence 43| UCACAAGGUAUUGACUGGCGUA |64
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1031676297 8 dbSNP
rs1249861366 14 dbSNP
rs115769169 17 dbSNP
rs968846507 19 dbSNP
rs540870271 20 dbSNP
rs993130937 22 dbSNP
Putative Targets

Gene Information
Gene Symbol PTBP1   
Synonyms HNRNP-I, HNRNPI, HNRPI, PTB, PTB-1, PTB-T, PTB2, PTB3, PTB4, pPTB
Description polypyrimidine tract binding protein 1
Transcript NM_002819   
Other Transcripts NM_031990 , NM_031991   
Expression
Putative miRNA Targets on PTBP1
3'UTR of PTBP1
(miRNA target sites are highlighted)		 
>PTBP1|NM_002819|3'UTR
   1 GGGCACAGGCCCCCACGGCCGGGCCCCCTGGCGACAACTTCCATCATTCCAGAGAAAAGCCACTTTAAAAACAGCTGAAG
  81 TGACCTTAGCAGACCAGAGATTTTATTTTTTTAAAGAGAAATCAGTTTACCTGTTTTTAAAAAAATTAAATCTAGTTCAC
 161 CTTGCTCACCCTGCGGTGACAGGGACAGCTCAGGCTCTTGGTGACTGTGGCAGCGGGAGTTCCCGGCCCTCCACACCCGG
 241 GGCCAGACCCTCGGGGCCATGCCTTGGTGGGGCCTGTGTCGGGCGTGGGGCCTGCAGGTGGGCGCCCCGACCACGACTTG
 321 GCTTCCTTGTGCCTTAAAAAACCTGCCTTCCTGCAGCCACACACCCACCCGGGGTGTCCTGGGGACCCAAGGGGTGGGGG
 401 GGTCACACCAGAGAGAGGCAGGGGGCCTGGCCGGCTCCTGCAGGATCATGCAGCTGGGGCGCGGCGGCCGCGGCTGCGAC
 481 ACCCCAACCCCAGCCCTCTAATCAAGTCACGTGATTCTCCCTTCACCCCGCCCCCAGGGCCTTCCCTTCTGCCCCCAGGC
 561 GGGCTCCCCGCTGCTCCAGCTGCGGAGCTGGTCGACATAATCTCTGTATTATATACTTTGCAGTTGCAGACGTCTGTGCC
 641 TAGCAATATTTCCAGTTGACCAAATATTCTAATCTTTTTTCATTTATATGCAAAAGAAATAGTTTTAAGTAACTTTTTAT
 721 AGCAAGATGATACAATGGTATGAGTGTAATCTAAACTTCCTTGTGGTATTACCTTGTATGCTGTTACTTTTATTTTATTC
 801 CTTGTAATTAAGTCACAGGCAGGACCCAGTTTCCAGAGAGCAGGCGGGGCCGCCCAGTGGGTCAGGCACAGGGAGCCCCG
 881 GTCCTATCTTAGAGCCCCTGAGCTTCAGGGAAGGGGCGGGCGTGTCGCCGCCTCTGGCATCGCCTCCGGTTGCCTTACAC
 961 CACGCCTTCACCTGCAGTCGCCTAGAAAACTTGCTCTCAAACTTCAGGGTTTTTTCTTCCTTCAAATTTTGGACCAAAGT
1041 CTCATTTCTGTGTTTTGCCTGCCTCTGATGCTGGGACCCGGAAGGCGGGCGCTCCTCCTGTCTTCTCTGTGCTCTTTCTA
1121 CCGCCCCCGCGTCCTGTCCCGGGGGCTCTCCTAGGATCCCCTTTCCGTAAAAGCGTGTAACAAGGGTGTAAATATTTATA
1201 ATTTTTTATACCTGTTGTGAGACCCGAGGGGCGGCGGCGCGGTTTTTTATGGTGACACAAATGTATATTTTGCTAACAGC
1281 AATTCCAGGCTCAGTATTGTGACCGCGGAGCCACAGGGGACCCCACGCACATTCCGTTGCCTTACCCGATGGCTTGTGAC
1361 GCGGAGAGAACCGATTAAAACCGTTTGAGAAACTCCTCCCTTGTCTAGCCCTGTGTTCGCTGTGGACGCTGTAGAGGCAG
1441 GTTGGCCAGTCTGTACCTGGACTTCGAATAAATCTTCTGTATCCTCGCTCCGTTCCGCCTTAAAAAAAAAAAAAAAAAAA
1521 AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auGCGGUCAGUU-AUGGAACACu 5'
            | | | |::: | ||||||| 
Target 5' acCACGACTTGGCTTCCTTGTGc 3'
 310 - 332 148.00 -12.01
2 
miRNA  3' augcgGUCAG--UU-AUGGAACACu 5'
               :| ||  || | ||||||| 
Target 5' gagtgTAATCTAAACTTCCTTGTGg 3'
 742 - 766 147.00 -10.80
3 
miRNA  3' augcGGUCAGUUAUGGAACAcu 5'
              ::| |: || ||||||  
Target 5' acttTTATTTTATTCCTTGTaa 3'
 786 - 807 134.00 -5.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31511575 2 COSMIC
COSN1219925 7 COSMIC
COSN26990786 17 COSMIC
COSN30458432 42 COSMIC
COSN26990785 60 COSMIC
COSN28718662 78 COSMIC
COSN30153622 98 COSMIC
COSN1219928 128 COSMIC
COSN30186129 132 COSMIC
COSN31602513 140 COSMIC
COSN30526746 146 COSMIC
COSN31537557 304 COSMIC
COSN7451914 393 COSMIC
COSN1219932 403 COSMIC
COSN31539554 433 COSMIC
COSN23855101 594 COSMIC
COSN20115240 678 COSMIC
COSN31518404 847 COSMIC
COSN31561984 943 COSMIC
COSN16436801 997 COSMIC
COSN31516390 1042 COSMIC
COSN24579781 1049 COSMIC
COSN31551154 1059 COSMIC
COSN1219936 1098 COSMIC
COSN20115242 1106 COSMIC
COSN8606758 1125 COSMIC
COSN30172180 1220 COSMIC
COSN31491024 1227 COSMIC
COSN1773332 1258 COSMIC
COSN28054169 1264 COSMIC
COSN31534431 1318 COSMIC
COSN31537702 1328 COSMIC
COSN31534505 1388 COSMIC
COSN28834978 1406 COSMIC
COSN29304879 1440 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs762387639 3 dbSNP
rs772568395 5 dbSNP
rs773771780 7 dbSNP
rs761228647 8 dbSNP
rs1314349849 10 dbSNP
rs374189015 11 dbSNP
rs1376500753 12 dbSNP
rs1451075325 14 dbSNP
rs1189207349 15 dbSNP
rs369836566 17 dbSNP
rs377729244 18 dbSNP
rs11549880 21 dbSNP
rs758618601 22 dbSNP
rs757186446 25 dbSNP
rs376079799 26 dbSNP
rs553778543 27 dbSNP
rs1486114266 29 dbSNP
rs745623176 29 dbSNP
rs867069330 31 dbSNP
rs755735292 33 dbSNP
rs368360037 34 dbSNP
rs1179296604 36 dbSNP
rs1027606293 37 dbSNP
rs780587322 38 dbSNP
rs768210577 39 dbSNP
rs1335110266 40 dbSNP
rs1232352805 41 dbSNP
rs773822507 42 dbSNP
rs747502754 43 dbSNP
rs754622166 52 dbSNP
rs968200434 55 dbSNP
rs978457862 60 dbSNP
rs112403800 74 dbSNP
rs1399011159 85 dbSNP
rs1169001164 86 dbSNP
rs1461374197 96 dbSNP
rs113969499 99 dbSNP
rs1428025957 101 dbSNP
rs1415847122 104 dbSNP
rs1190127898 106 dbSNP
rs925688754 106 dbSNP
rs1251404399 110 dbSNP
rs1064511 113 dbSNP
rs950590809 114 dbSNP
rs937116661 117 dbSNP
rs983269232 119 dbSNP
rs1273370947 120 dbSNP
rs1209240866 125 dbSNP
rs146434169 127 dbSNP
rs1274544862 129 dbSNP
rs965737194 131 dbSNP
rs548810493 132 dbSNP
rs949961097 138 dbSNP
rs1277421173 139 dbSNP
rs1337970748 139 dbSNP
rs1291157599 140 dbSNP
rs1352129483 145 dbSNP
rs1440885551 146 dbSNP
rs1392879831 147 dbSNP
rs1047023414 148 dbSNP
rs752416108 152 dbSNP
rs1267398556 161 dbSNP
rs567418221 162 dbSNP
rs755980737 170 dbSNP
rs191561964 171 dbSNP
rs1192737101 175 dbSNP
rs935715070 175 dbSNP
rs1466935813 176 dbSNP
rs1254837469 177 dbSNP
rs990796644 180 dbSNP
rs913509576 182 dbSNP
rs1281517980 183 dbSNP
rs1225173782 185 dbSNP
rs1483022442 187 dbSNP
rs777851930 202 dbSNP
rs1280549475 206 dbSNP
rs1328537227 215 dbSNP
rs753887820 215 dbSNP
rs1442199983 216 dbSNP
rs1045902704 218 dbSNP
rs1344758016 222 dbSNP
rs553238908 223 dbSNP
rs577984150 224 dbSNP
rs538579104 225 dbSNP
rs1406421917 226 dbSNP
rs866302648 229 dbSNP
rs758492495 230 dbSNP
rs780283081 232 dbSNP
rs558098512 233 dbSNP
rs1239910983 235 dbSNP
rs1217271915 237 dbSNP
rs1017458420 238 dbSNP
rs1277505019 238 dbSNP
rs138712270 239 dbSNP
rs1346177567 240 dbSNP
rs1306083751 241 dbSNP
rs1235748552 242 dbSNP
rs1361847537 245 dbSNP
rs1268888224 246 dbSNP
rs1433002671 249 dbSNP
rs886330894 250 dbSNP
rs1345800315 251 dbSNP
rs1312501566 253 dbSNP
rs561483044 253 dbSNP
rs1174006573 254 dbSNP
rs1460007167 256 dbSNP
rs768778252 258 dbSNP
rs1417334679 260 dbSNP
rs974693544 262 dbSNP
rs1256116638 263 dbSNP
rs1352000694 264 dbSNP
rs1410190881 267 dbSNP
rs1486442903 267 dbSNP
rs1033844740 268 dbSNP
rs1287560150 268 dbSNP
rs1371001202 271 dbSNP
rs1216766525 275 dbSNP
rs1220899521 277 dbSNP
rs573288955 278 dbSNP
rs991651968 281 dbSNP
rs1461314679 282 dbSNP
rs1311651226 283 dbSNP
rs1018696817 285 dbSNP
rs1172454341 291 dbSNP
rs965891699 298 dbSNP
rs1416608136 302 dbSNP
rs1185134706 303 dbSNP
rs543850823 304 dbSNP
rs562038406 305 dbSNP
rs957244367 306 dbSNP
rs989809461 308 dbSNP
rs912901310 309 dbSNP
rs1272669538 310 dbSNP
rs1319182485 310 dbSNP
rs899665838 311 dbSNP
rs967587957 313 dbSNP
rs866729000 315 dbSNP
rs1192317142 317 dbSNP
rs1425130447 318 dbSNP
rs1393607749 323 dbSNP
rs928785388 327 dbSNP
rs1417882983 328 dbSNP
rs937525273 335 dbSNP
rs1179298198 336 dbSNP
rs1406292993 336 dbSNP
rs1416938259 336 dbSNP
rs1009505065 342 dbSNP
rs184188148 343 dbSNP
rs920044520 344 dbSNP
rs931405787 347 dbSNP
rs541209629 348 dbSNP
rs887115209 351 dbSNP
rs1352581085 352 dbSNP
rs1369891897 353 dbSNP
rs1323825048 355 dbSNP
rs1442997031 357 dbSNP
rs1438400358 358 dbSNP
rs1004756159 365 dbSNP
rs1394670834 366 dbSNP
rs959817068 368 dbSNP
rs544145795 371 dbSNP
rs901671690 372 dbSNP
rs1440703916 373 dbSNP
rs996048835 379 dbSNP
rs1029261783 380 dbSNP
rs1455961764 382 dbSNP
rs982434606 385 dbSNP
rs1204605867 387 dbSNP
rs1484903751 388 dbSNP
rs535012823 391 dbSNP
rs71335272 391 dbSNP
rs1299924536 395 dbSNP
rs1300980037 396 dbSNP
rs370152508 396 dbSNP
rs879905087 396 dbSNP
rs1331588572 397 dbSNP
rs6698 398 dbSNP
rs1050968096 401 dbSNP
rs912625676 402 dbSNP
rs8492 405 dbSNP
rs1433698352 406 dbSNP
rs773693889 407 dbSNP
rs1375292484 408 dbSNP
rs370441188 409 dbSNP
rs763045364 410 dbSNP
rs551799960 411 dbSNP
rs1378739498 413 dbSNP
rs1042368558 424 dbSNP
rs903867910 426 dbSNP
rs1263932961 428 dbSNP
rs1485451059 429 dbSNP
rs1277985567 431 dbSNP
rs1212784956 433 dbSNP
rs981680621 433 dbSNP
rs1250696416 434 dbSNP
rs928898318 435 dbSNP
rs1278272687 436 dbSNP
rs1413830093 439 dbSNP
rs1166930408 440 dbSNP
rs1055800737 441 dbSNP
rs895295588 442 dbSNP
rs958840916 449 dbSNP
rs1417015322 450 dbSNP
rs991647163 451 dbSNP
rs920098529 452 dbSNP
rs931376100 455 dbSNP
rs968637057 456 dbSNP
rs1167907937 458 dbSNP
rs1460916888 459 dbSNP
rs1374905024 460 dbSNP
rs1171451872 461 dbSNP
rs1047632644 463 dbSNP
rs1003965817 464 dbSNP
rs1190247915 464 dbSNP
rs1249541170 464 dbSNP
rs1255710982 464 dbSNP
rs1393556228 465 dbSNP
rs908544765 465 dbSNP
rs1341347276 466 dbSNP
rs1438643981 466 dbSNP
rs1331975383 467 dbSNP
rs944071421 467 dbSNP
rs1040250491 468 dbSNP
rs962383119 469 dbSNP
rs1322585073 470 dbSNP
rs901745430 471 dbSNP
rs996510584 472 dbSNP
rs563252071 473 dbSNP
rs1332587526 474 dbSNP
rs892962195 478 dbSNP
rs1415695038 479 dbSNP
rs374322028 480 dbSNP
rs1011322543 481 dbSNP
rs987032214 481 dbSNP
rs1020079592 482 dbSNP
rs530424588 483 dbSNP
rs1229239968 485 dbSNP
rs945425280 486 dbSNP
rs1212915032 488 dbSNP
rs1289617461 491 dbSNP
rs1466799973 493 dbSNP
rs78940050 495 dbSNP
rs1228573621 496 dbSNP
rs925260023 497 dbSNP
rs1379489983 498 dbSNP
rs1438690701 499 dbSNP
rs567354981 499 dbSNP
rs895377196 504 dbSNP
rs773756367 505 dbSNP
rs949700034 512 dbSNP
rs868649851 514 dbSNP
rs1240002258 515 dbSNP
rs1441315434 516 dbSNP
rs1473578267 517 dbSNP
rs958955734 518 dbSNP
rs1046960579 519 dbSNP
rs1275679995 520 dbSNP
rs528224322 521 dbSNP
rs886613271 522 dbSNP
rs1445879041 525 dbSNP
rs1027152620 526 dbSNP
rs1281705002 526 dbSNP
rs1356363961 527 dbSNP
rs1310442897 528 dbSNP
rs1161244361 530 dbSNP
rs374914203 530 dbSNP
rs978663969 530 dbSNP
rs759135437 531 dbSNP
rs187619178 532 dbSNP
rs908657554 534 dbSNP
rs1316509228 535 dbSNP
rs944145213 535 dbSNP
rs1400179368 536 dbSNP
rs369303363 537 dbSNP
rs866136026 539 dbSNP
rs1316397056 540 dbSNP
rs1421752607 540 dbSNP
rs921271580 541 dbSNP
rs1360980232 542 dbSNP
rs931878192 545 dbSNP
rs1028022970 547 dbSNP
rs767050320 550 dbSNP
rs1353985658 551 dbSNP
rs1488395305 552 dbSNP
rs752465299 552 dbSNP
rs1230681398 553 dbSNP
rs892963016 554 dbSNP
rs1213803556 557 dbSNP
rs1350675790 558 dbSNP
rs763996721 560 dbSNP
rs947235368 561 dbSNP
rs1041467388 566 dbSNP
rs1281543981 566 dbSNP
rs1402138836 567 dbSNP
rs1443739309 567 dbSNP
rs1187855165 569 dbSNP
rs571483393 570 dbSNP
rs902910302 571 dbSNP
rs1002634994 572 dbSNP
rs1474089334 574 dbSNP
rs1035318010 575 dbSNP
rs1412614496 577 dbSNP
rs1172164436 578 dbSNP
rs1452968251 579 dbSNP
rs1256405373 581 dbSNP
rs1156827432 582 dbSNP
rs538884734 583 dbSNP
rs1482487649 584 dbSNP
rs954925734 584 dbSNP
rs1239561437 585 dbSNP
rs1013162731 589 dbSNP
rs556978238 592 dbSNP
rs1415213956 594 dbSNP
rs75366733 595 dbSNP
rs982889753 598 dbSNP
rs1412065352 601 dbSNP
rs1015729084 603 dbSNP
rs1335627908 605 dbSNP
rs1441450164 605 dbSNP
rs965400410 606 dbSNP
rs537040076 607 dbSNP
rs1352708154 608 dbSNP
rs757288227 609 dbSNP
rs1277228232 611 dbSNP
rs1346468841 612 dbSNP
rs976807631 613 dbSNP
rs1416445969 614 dbSNP
rs1046655570 615 dbSNP
rs1425178182 615 dbSNP
rs921271322 616 dbSNP
rs886582133 617 dbSNP
rs555374450 620 dbSNP
rs940820735 621 dbSNP
rs1037903220 622 dbSNP
rs1201011328 622 dbSNP
rs898241224 629 dbSNP
rs1484524103 630 dbSNP
rs986052296 632 dbSNP
rs1219697449 634 dbSNP
rs1028368483 635 dbSNP
rs1313644774 639 dbSNP
rs889468379 640 dbSNP
rs573773195 643 dbSNP
rs117390044 647 dbSNP
rs1418375622 649 dbSNP
rs1447404879 649 dbSNP
rs1041542025 652 dbSNP
rs903024534 653 dbSNP
rs1350146845 664 dbSNP
rs1157834447 665 dbSNP
rs1378841786 668 dbSNP
rs1379337756 668 dbSNP
rs377500807 670 dbSNP
rs1252502263 673 dbSNP
rs1440815780 673 dbSNP
rs1208155279 675 dbSNP
rs1489482453 675 dbSNP
rs977884378 675 dbSNP
rs1478391178 676 dbSNP
rs553114905 677 dbSNP
rs1287884980 678 dbSNP
rs1032173623 679 dbSNP
rs938410204 681 dbSNP
rs1056937467 682 dbSNP
rs1431877905 687 dbSNP
rs894130740 688 dbSNP
rs1299058061 690 dbSNP
rs958322143 691 dbSNP
rs1013021146 692 dbSNP
rs990926814 695 dbSNP
rs547062331 696 dbSNP
rs1359073394 697 dbSNP
rs547020093 697 dbSNP
rs773567554 699 dbSNP
rs1197290208 702 dbSNP
rs1390069113 702 dbSNP
rs144706381 704 dbSNP
rs568410045 706 dbSNP
rs982543693 707 dbSNP
rs1186211992 708 dbSNP
rs1487411615 714 dbSNP
rs1326082932 716 dbSNP
rs751569646 726 dbSNP
rs1026670920 734 dbSNP
rs1332234644 737 dbSNP
rs888667643 737 dbSNP
rs1004431465 738 dbSNP
rs1235310556 741 dbSNP
rs940956161 742 dbSNP
rs1294199319 743 dbSNP
rs1015674952 744 dbSNP
rs1342013582 744 dbSNP
rs920764865 745 dbSNP
rs965555971 746 dbSNP
rs1400997181 749 dbSNP
rs1302066486 750 dbSNP
rs1171394002 751 dbSNP
rs1345218549 752 dbSNP
rs545632371 754 dbSNP
rs1251630845 756 dbSNP
rs1476861027 760 dbSNP
rs1480167762 763 dbSNP
rs1194590624 766 dbSNP
rs1485257835 767 dbSNP
rs755125121 773 dbSNP
rs1202147380 774 dbSNP
rs998216836 775 dbSNP
rs931023966 777 dbSNP
rs148457180 779 dbSNP
rs1278456610 784 dbSNP
rs531272883 784 dbSNP
rs1007877238 788 dbSNP
rs1040718418 788 dbSNP
rs902434315 789 dbSNP
rs989861495 793 dbSNP
rs915256886 797 dbSNP
rs1468866457 798 dbSNP
rs542237407 802 dbSNP
rs1464146834 804 dbSNP
rs1193028387 806 dbSNP
rs1171742189 808 dbSNP
rs977376750 808 dbSNP
rs539547516 810 dbSNP
rs1451516925 813 dbSNP
rs1189390202 815 dbSNP
rs1169435084 821 dbSNP
rs1372773068 822 dbSNP
rs1460773516 825 dbSNP
rs1165428853 826 dbSNP
rs957908722 827 dbSNP
rs1391996379 828 dbSNP
rs938526000 828 dbSNP
rs1212722159 830 dbSNP
rs535829782 834 dbSNP
rs1440838190 837 dbSNP
rs1324574789 843 dbSNP
rs1285538329 848 dbSNP
rs1247453579 849 dbSNP
rs528161285 852 dbSNP
rs546728150 856 dbSNP
rs191368344 859 dbSNP
rs1048502181 865 dbSNP
rs888122744 867 dbSNP
rs1004417092 870 dbSNP
rs1404791211 871 dbSNP
rs1388886230 872 dbSNP
rs1306631203 876 dbSNP
rs551332435 877 dbSNP
rs1458231381 878 dbSNP
rs1379437896 879 dbSNP
rs1176773073 881 dbSNP
rs1267010777 881 dbSNP
rs1441429443 882 dbSNP
rs1335342255 883 dbSNP
rs1449333011 887 dbSNP
rs901336279 888 dbSNP
rs998332905 889 dbSNP
rs1028506973 891 dbSNP
rs1357581334 893 dbSNP
rs954239189 895 dbSNP
rs1200291931 897 dbSNP
rs1310582421 898 dbSNP
rs1010997373 899 dbSNP
rs1329356512 901 dbSNP
rs1325843682 909 dbSNP
rs973660153 910 dbSNP
rs1359705162 911 dbSNP
rs1022676105 914 dbSNP
rs1466292615 916 dbSNP
rs920733145 918 dbSNP
rs966736428 921 dbSNP
rs532202513 923 dbSNP
rs1051058483 925 dbSNP
rs1247947343 927 dbSNP
rs781265353 929 dbSNP
rs924548971 930 dbSNP
rs11549879 931 dbSNP
rs993042227 935 dbSNP
rs1446043790 936 dbSNP
rs915754509 939 dbSNP
rs1214949390 942 dbSNP
rs948436900 942 dbSNP
rs1189980869 943 dbSNP
rs1219141450 945 dbSNP
rs770079553 947 dbSNP
rs569040469 948 dbSNP
rs902223138 949 dbSNP
rs1163361435 951 dbSNP
rs1340143670 954 dbSNP
rs1391529151 955 dbSNP
rs909543953 956 dbSNP
rs999387412 957 dbSNP
rs1288949121 959 dbSNP
rs1053654888 961 dbSNP
rs939717706 962 dbSNP
rs893734131 963 dbSNP
rs1037227295 964 dbSNP
rs1023897912 965 dbSNP
rs187053484 966 dbSNP
rs377260311 967 dbSNP
rs998459343 968 dbSNP
rs567336992 972 dbSNP
rs889961694 973 dbSNP
rs1281279469 976 dbSNP
rs1011401482 980 dbSNP
rs1022409523 981 dbSNP
rs1220694304 982 dbSNP
rs1340943679 983 dbSNP
rs1331220915 984 dbSNP
rs1216503963 986 dbSNP
rs534751479 994 dbSNP
rs999505025 997 dbSNP
rs1474849688 1000 dbSNP
rs1397481885 1001 dbSNP
rs1172454978 1002 dbSNP
rs1202425879 1003 dbSNP
rs973632154 1006 dbSNP
rs1181658303 1007 dbSNP
rs953768942 1009 dbSNP
rs1239726060 1012 dbSNP
rs1475070602 1013 dbSNP
rs1186321001 1016 dbSNP
rs11925 1017 dbSNP
rs959911207 1019 dbSNP
rs992762205 1020 dbSNP
rs1023219107 1021 dbSNP
rs1308329239 1022 dbSNP
rs1312231689 1024 dbSNP
rs943784560 1026 dbSNP
rs1284766899 1027 dbSNP
rs1420222111 1033 dbSNP
rs1159138197 1041 dbSNP
rs969950432 1042 dbSNP
rs1332765667 1044 dbSNP
rs984264198 1045 dbSNP
rs1348969961 1049 dbSNP
rs200029696 1049 dbSNP
rs1403964872 1051 dbSNP
rs1375744304 1056 dbSNP
rs1184797840 1058 dbSNP
rs934976006 1060 dbSNP
rs115464239 1064 dbSNP
rs1236834015 1066 dbSNP
rs1352193267 1070 dbSNP
rs1224293692 1072 dbSNP
rs893690505 1078 dbSNP
rs1219632534 1079 dbSNP
rs947968421 1080 dbSNP
rs1323351432 1081 dbSNP
rs3200346 1085 dbSNP
rs578079814 1086 dbSNP
rs1239391959 1087 dbSNP
rs906392076 1088 dbSNP
rs1446887875 1089 dbSNP
rs1003615560 1090 dbSNP
rs1015038350 1091 dbSNP
rs201215954 1092 dbSNP
rs3837989 1092 dbSNP
rs1485471467 1093 dbSNP
rs1209106867 1094 dbSNP
rs994808670 1095 dbSNP
rs1028075422 1097 dbSNP
rs1254451228 1097 dbSNP
rs386805681 1097 dbSNP
rs148682484 1098 dbSNP
rs370955727 1098 dbSNP
rs370092254 1101 dbSNP
rs986823585 1101 dbSNP
rs374079141 1103 dbSNP
rs200554672 1104 dbSNP
rs868188154 1104 dbSNP
rs144356088 1105 dbSNP
rs750353617 1105 dbSNP
rs1215668855 1106 dbSNP
rs776733124 1106 dbSNP
rs1177105074 1107 dbSNP
rs111765185 1108 dbSNP
rs1288093366 1108 dbSNP
rs1416779449 1109 dbSNP
rs1239660894 1110 dbSNP
rs977578500 1112 dbSNP
rs1220406155 1113 dbSNP
rs1298534638 1113 dbSNP
rs1345787506 1114 dbSNP
rs1297130847 1117 dbSNP
rs572907022 1119 dbSNP
rs1433728240 1122 dbSNP
rs533688077 1123 dbSNP
rs989121557 1124 dbSNP
rs191858699 1125 dbSNP
rs575820360 1128 dbSNP
rs1050048218 1129 dbSNP
rs543359265 1130 dbSNP
rs889940562 1131 dbSNP
rs1371164578 1132 dbSNP
rs1193144022 1135 dbSNP
rs1487218599 1137 dbSNP
rs1221010446 1138 dbSNP
rs1265053905 1139 dbSNP
rs369269126 1140 dbSNP
rs1347369366 1141 dbSNP
rs1254132497 1142 dbSNP
rs1234789564 1145 dbSNP
rs1232414547 1146 dbSNP
rs572878890 1146 dbSNP
rs540276649 1147 dbSNP
rs1216412427 1148 dbSNP
rs1043938528 1149 dbSNP
rs1298152943 1150 dbSNP
rs902574219 1151 dbSNP
rs999619320 1156 dbSNP
rs1034979977 1159 dbSNP
rs564963507 1160 dbSNP
rs1014578441 1161 dbSNP
rs994923211 1162 dbSNP
rs1425992971 1164 dbSNP
rs532268155 1165 dbSNP
rs573327827 1166 dbSNP
rs983945864 1167 dbSNP
rs1019592813 1173 dbSNP
rs1256837838 1174 dbSNP
rs1016734666 1175 dbSNP
rs961076288 1176 dbSNP
rs1228616380 1178 dbSNP
rs1251483155 1178 dbSNP
rs1340185684 1179 dbSNP
rs1311279159 1182 dbSNP
rs1455047163 1186 dbSNP
rs10404848 1188 dbSNP
rs1383669234 1190 dbSNP
rs1031804261 1191 dbSNP
rs1453380831 1193 dbSNP
rs956454201 1195 dbSNP
rs1421264799 1196 dbSNP
rs1410306477 1198 dbSNP
rs989669185 1198 dbSNP
rs972457354 1199 dbSNP
rs11549884 1201 dbSNP
rs1237437531 1202 dbSNP
rs562458013 1202 dbSNP
rs980479414 1208 dbSNP
rs1326615762 1210 dbSNP
rs1370298064 1211 dbSNP
rs1438870218 1212 dbSNP
rs927835065 1213 dbSNP
rs1356169118 1218 dbSNP
rs933701694 1228 dbSNP
rs1248563537 1229 dbSNP
rs1360831799 1230 dbSNP
rs986100153 1233 dbSNP
rs919128307 1234 dbSNP
rs139988074 1235 dbSNP
rs1428941460 1237 dbSNP
rs946975132 1241 dbSNP
rs199927021 1242 dbSNP
rs112450489 1243 dbSNP
rs924109350 1244 dbSNP
rs1271338275 1245 dbSNP
rs1007945078 1247 dbSNP
rs1379616083 1250 dbSNP
rs1156700236 1253 dbSNP
rs1040361178 1254 dbSNP
rs1214892986 1259 dbSNP
rs902064395 1259 dbSNP
rs1268974631 1263 dbSNP
rs1286003759 1264 dbSNP
rs935401374 1264 dbSNP
rs577486380 1265 dbSNP
rs548087183 1266 dbSNP
rs566478333 1267 dbSNP
rs957562751 1268 dbSNP
rs1191269522 1273 dbSNP
rs1243483257 1275 dbSNP
rs1010637212 1279 dbSNP
rs1329594122 1280 dbSNP
rs1305112401 1285 dbSNP
rs896464573 1286 dbSNP
rs1012272512 1287 dbSNP
rs1402340948 1290 dbSNP
rs1408137150 1293 dbSNP
rs865852870 1295 dbSNP
rs1417168123 1296 dbSNP
rs1476718406 1300 dbSNP
rs1430994682 1305 dbSNP
rs1462856729 1306 dbSNP
rs1165535198 1307 dbSNP
rs1481009085 1313 dbSNP
rs1262887364 1314 dbSNP
rs1215150403 1315 dbSNP
rs534690137 1317 dbSNP
rs1393722752 1319 dbSNP
rs1459940106 1320 dbSNP
rs767767291 1321 dbSNP
rs1342884617 1325 dbSNP
rs980810175 1325 dbSNP
rs927614287 1327 dbSNP
rs1320378077 1328 dbSNP
rs1432575949 1330 dbSNP
rs1345720662 1331 dbSNP
rs905750653 1335 dbSNP
rs546627256 1336 dbSNP
rs1430302762 1340 dbSNP
rs571631532 1341 dbSNP
rs1016682346 1343 dbSNP
rs1176765940 1344 dbSNP
rs1059714 1347 dbSNP
rs919075936 1348 dbSNP
rs1185177346 1349 dbSNP
rs557239242 1350 dbSNP
rs930450696 1354 dbSNP
rs763692270 1356 dbSNP
rs1460089050 1357 dbSNP
rs1265048005 1359 dbSNP
rs1204600039 1361 dbSNP
rs1293198084 1362 dbSNP
rs1333421898 1363 dbSNP
rs1029392363 1364 dbSNP
rs1256324991 1364 dbSNP
rs1048902197 1365 dbSNP
rs955319014 1366 dbSNP
rs985115330 1373 dbSNP
rs1445695722 1374 dbSNP
rs1447177292 1383 dbSNP
rs14613 1384 dbSNP
rs1464615512 1385 dbSNP
rs1240051459 1391 dbSNP
rs1040351241 1392 dbSNP
rs1490113006 1393 dbSNP
rs901886024 1396 dbSNP
rs1416996296 1397 dbSNP
rs999049778 1399 dbSNP
rs968291933 1400 dbSNP
rs893406001 1401 dbSNP
rs1231454204 1404 dbSNP
rs1206884515 1408 dbSNP
rs1288856424 1409 dbSNP
rs979722355 1409 dbSNP
rs924099606 1410 dbSNP
rs1023139404 1411 dbSNP
rs756493020 1411 dbSNP
rs969501994 1412 dbSNP
rs536900173 1416 dbSNP
rs1385798751 1417 dbSNP
rs1400229912 1418 dbSNP
rs1316459619 1419 dbSNP
rs184756253 1421 dbSNP
rs1299590875 1423 dbSNP
rs1415777186 1429 dbSNP
rs1034674545 1437 dbSNP
rs1423085557 1438 dbSNP
rs1387647879 1441 dbSNP
rs1293064611 1443 dbSNP
rs1056542010 1444 dbSNP
rs917982297 1446 dbSNP
rs948146370 1447 dbSNP
rs971743234 1447 dbSNP
rs1179225648 1449 dbSNP
rs1481096432 1452 dbSNP
rs1246308666 1454 dbSNP
rs1354047080 1457 dbSNP
rs1045039132 1458 dbSNP
rs1490761724 1459 dbSNP
rs573619227 1461 dbSNP
rs540217903 1462 dbSNP
rs1308490442 1464 dbSNP
rs1314653501 1464 dbSNP
rs1005422230 1466 dbSNP
rs1291360454 1467 dbSNP
rs1366507569 1467 dbSNP
rs1403550556 1469 dbSNP
rs200641173 1473 dbSNP
rs1304323570 1474 dbSNP
rs1222766769 1475 dbSNP
rs564923156 1476 dbSNP
rs576833547 1478 dbSNP
rs1038284067 1479 dbSNP
rs1481331195 1480 dbSNP
rs1269289795 1481 dbSNP
rs934638165 1482 dbSNP
rs544308419 1483 dbSNP
rs114903089 1484 dbSNP
rs1211267431 1485 dbSNP
rs1215887974 1487 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' augcggUCAGUU-AUGGAACACu 5'
                | |::: | ||||||| 
Target 5' ------ACUUGGCUUCCUUGUGc 3'
 		1 - 17
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HCT116
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in ERX177603. RNA binding protein: AGO2. Condition:p53_D_AGO_CLIP_2_5 ...

- Krell J; Stebbing J; Carissimi C; Dabrowska et al., 2016, Genome research.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' augcggucaguuAUGGAACACu 5'
                      | ||||||| 
Target 5' -----------cUUCCUUGUGc 3'
 		1 - 11
Article - Krell J; Stebbing J; Carissimi C; Dabrowska et al.
- Genome research, 2016
DNA damage activates TP53-regulated surveillance mechanisms that are crucial in suppressing tumorigenesis. TP53 orchestrates these responses directly by transcriptionally modulating genes, including microRNAs (miRNAs), and by regulating miRNA biogenesis through interacting with the DROSHA complex. However, whether the association between miRNAs and AGO2 is regulated following DNA damage is not yet known. Here, we show that, following DNA damage, TP53 interacts with AGO2 to induce or reduce AGO2's association of a subset of miRNAs, including multiple let-7 family members. Furthermore, we show that specific mutations in TP53 decrease rather than increase the association of let-7 family miRNAs, reducing their activity without preventing TP53 from interacting with AGO2. This is consistent with the oncogenic properties of these mutants. Using AGO2 RIP-seq and PAR-CLIP-seq, we show that the DNA damage-induced increase in binding of let-7 family members to the RISC complex is functional. We unambiguously determine the global miRNA-mRNA interaction networks involved in the DNA damage response, validating them through the identification of miRNA-target chimeras formed by endogenous ligation reactions. We find that the target complementary region of the let-7 seed tends to have highly fixed positions and more variable ones. Additionally, we observe that miRNAs, whose cellular abundance or differential association with AGO2 is regulated by TP53, are involved in an intricate network of regulatory feedback and feedforward circuits. TP53-mediated regulation of AGO2-miRNA interaction represents a new mechanism of miRNA regulation in carcinogenesis.
LinkOut: [PMID: 26701625]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000350092.4 | 3UTR | ACUUGGCUUCCUUGUGCCUUAAAAAACCUGCCUUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
83 hsa-miR-4457 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT098032 SOBP sine oculis binding protein homolog 2 2
MIRT202580 PCMTD2 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 2 2 6
MIRT247137 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT349266 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT363756 EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2 2
MIRT443586 FAM84B family with sequence similarity 84 member B 2 2
MIRT452333 EIF5AL1 eukaryotic translation initiation factor 5A-like 1 2 2
MIRT453864 ZBTB40 zinc finger and BTB domain containing 40 2 4
MIRT471486 PDE4D phosphodiesterase 4D 2 4
MIRT476290 GMFB glia maturation factor beta 2 8
MIRT479897 CCDC117 coiled-coil domain containing 117 2 4
MIRT484251 ANK1 ankyrin 1 2 2
MIRT491473 TMEM214 transmembrane protein 214 2 2
MIRT493804 GAN gigaxonin 2 6
MIRT499252 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT502271 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 4
MIRT504651 RPL9 ribosomal protein L9 2 6
MIRT505211 UBN2 ubinuclein 2 2 8
MIRT508952 SNRPB small nuclear ribonucleoprotein polypeptides B and B1 2 4
MIRT512691 POP1 POP1 homolog, ribonuclease P/MRP subunit 2 2
MIRT513320 SCUBE3 signal peptide, CUB domain and EGF like domain containing 3 2 2
MIRT513870 HOXA5 homeobox A5 2 2
MIRT517342 ZNF529 zinc finger protein 529 2 4
MIRT518947 LSG1 large 60S subunit nuclear export GTPase 1 2 2
MIRT520867 SUGT1 SGT1 homolog, MIS12 kinetochore complex assembly cochaperone 2 2
MIRT528325 GIGYF2 GRB10 interacting GYF protein 2 2 2
MIRT531990 SLCO1B3 solute carrier organic anion transporter family member 1B3 2 2
MIRT533298 USP46 ubiquitin specific peptidase 46 2 2
MIRT545257 TRIM36 tripartite motif containing 36 2 4
MIRT547038 POGZ pogo transposable element derived with ZNF domain 2 2
MIRT556103 MOAP1 modulator of apoptosis 1 2 2
MIRT558321 DR1 down-regulator of transcription 1 2 2
MIRT558521 CSRNP3 cysteine and serine rich nuclear protein 3 2 2
MIRT560906 TMED10 transmembrane p24 trafficking protein 10 2 2
MIRT568448 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT570586 OTUD7B OTU deubiquitinase 7B 2 2
MIRT572799 SIGLEC14 sialic acid binding Ig like lectin 14 2 2
MIRT573863 C9orf78 chromosome 9 open reading frame 78 2 2
MIRT575058 P2ry1 purinergic receptor P2Y, G-protein coupled 1 2 5
MIRT609931 SLC38A1 solute carrier family 38 member 1 2 4
MIRT610836 ZNF585A zinc finger protein 585A 2 4
MIRT611474 P2RY1 purinergic receptor P2Y1 2 7
MIRT613569 YY2 YY2 transcription factor 2 2
MIRT618626 GREB1 growth regulation by estrogen in breast cancer 1 2 2
MIRT620606 SAP30 Sin3A associated protein 30 2 2
MIRT621017 CLSTN3 calsyntenin 3 2 4
MIRT635314 FAM179A TOG array regulator of axonemal microtubules 2 2 2
MIRT635919 GLTSCR2 NOP53 ribosome biogenesis factor 2 2
MIRT640598 TM9SF4 transmembrane 9 superfamily member 4 2 2
MIRT641784 YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta 2 4
MIRT644067 IQCE IQ motif containing E 2 2
MIRT648288 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT658085 FOXR2 forkhead box R2 2 2
MIRT659077 DEPTOR DEP domain containing MTOR interacting protein 2 2
MIRT665307 ZBTB37 zinc finger and BTB domain containing 37 2 2
MIRT665975 SYTL4 synaptotagmin like 4 2 2
MIRT666302 SLC25A25 solute carrier family 25 member 25 2 2
MIRT674906 RASSF9 Ras association domain family member 9 2 2
MIRT680086 THAP1 THAP domain containing 1 2 2
MIRT681488 DIP2A disco interacting protein 2 homolog A 2 2
MIRT691244 DFNB59 pejvakin 2 2
MIRT692362 AGTRAP angiotensin II receptor associated protein 2 2
MIRT693035 MB21D1 Mab-21 domain containing 1 2 2
MIRT693837 STAT5A signal transducer and activator of transcription 5A 2 2
MIRT694479 LRTOMT leucine rich transmembrane and O-methyltransferase domain containing 2 2
MIRT696070 ZNF264 zinc finger protein 264 2 2
MIRT696578 TTC21B tetratricopeptide repeat domain 21B 2 2
MIRT696760 MTFMT mitochondrial methionyl-tRNA formyltransferase 2 2
MIRT697307 ZNF652 zinc finger protein 652 2 2
MIRT700152 RNF115 ring finger protein 115 2 2
MIRT701056 PARP2 poly(ADP-ribose) polymerase 2 2 2
MIRT701198 OTUD3 OTU deubiquitinase 3 2 2
MIRT701335 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT702656 ITGA3 integrin subunit alpha 3 2 2
MIRT703618 FBXO45 F-box protein 45 2 2
MIRT704673 CHTOP chromatin target of PRMT1 2 2
MIRT708894 ZNF780A zinc finger protein 780A 2 2
MIRT711620 DGKH diacylglycerol kinase eta 2 2
MIRT713745 TMEM81 transmembrane protein 81 2 2
MIRT719712 CD101 CD101 molecule 2 2
MIRT720294 DLGAP3 DLG associated protein 3 2 2
MIRT722606 CCDC152 coiled-coil domain containing 152 2 2
MIRT724566 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-4 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4457 Dabrafenib 44462760 NSC764134 approved sensitive cell line (A375)
hsa-miR-4457 Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-4457 Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)

Error report submission