miRTarBase - #MIRT352597


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pre-miRNA Information
pre-miRNA hsa-mir-4760   
Genomic Coordinates chr21: 40212352 - 40212431
Description Homo sapiens miR-4760 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4760-5p
Sequence 10| UUUAGAUUGAACAUGAAGUUAG |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1305812532 3 dbSNP
rs776241608 7 dbSNP
Putative Targets

Gene Information
Gene Symbol PTMA   
Synonyms TMSA
Description prothymosin, alpha
Transcript NM_001099285   
Other Transcripts NM_002823   
Expression
Putative miRNA Targets on PTMA
3'UTR of PTMA
(miRNA target sites are highlighted)		 
>PTMA|NM_001099285|3'UTR
   1 ACAGCAAAAAAGGAAAAGTTAAACTAAAAAAAAAAAGGCCGCCGTGACCTATTCACCCTCCACTTCCCGTCTCAGAATCT
  81 AAACGTGGTCACCTTCGAGTAGAGAGGCCCGCCCGCCCACCGTGGGCAGTGCCACCCGCAGATGACACGCGCTCTCCACC
 161 ACCCAACCCAAACCATGAGAATTTGCAACAGGGGAGGAAAAAAGAACCAAAACTTCCAAGGCCCTGCTTTTTTTCTTAAA
 241 AGTACTTTAAAAAGGAAATTTGTTTGTATTTTTTATTTACATTTTATATTTTTGTACATATTGTTAGGGTCAGCCATTTT
 321 TAATGATCTCGGATGACCAAACCAGCCTTCGGAGCGTTCTCTGTCCTACTTCTGACTTTACTTGTGGTGTGACCATGTTC
 401 ATTATAATCTCAAAGGAGAAAAAAAACCTTGTAAAAAAAGCAAAAATGACAACAGAAAAACAATCTTATTCCGAGCATTC
 481 CAGTAACTTTTTTGTGTATGTACTTAGCTGTACTATAAGTAGTTGGTTTGTATGAGATGGTTAAAAAGGCCAAAGATAAA
 561 AGGTTTCTTTTTTTTTCCTTTTTTGTCTATGAAGTTGCTGTTTATTTTTTTTGGCCTGTTTGATGTATGTGTGAAACAAT
 641 GTTGTCCAACAATAAACAGGAATTTTATTTTGCTGAGTTGTTCTAACAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gauUGAAGUACA-AG--UUAGAUUu 5'
             |||||  || ||  ||||||| 
Target 5' tccACTTCCCGTCTCAGAATCTAAa 3'
 59 - 83 161.00 -10.90
2 
miRNA  3' gauugAAGUACAAGUUAGAUUu 5'
               ||||| | :||||| | 
Target 5' ccatgTTCAT-TATAATCTCAa 3'
 393 - 413 128.00 -8.80
3 
miRNA  3' gauugaaguacaaGUUAGAUUu 5'
                       |||||| | 
Target 5' gacaacagaaaaaCAATCTTAt 3'
 448 - 469 113.00 -5.12
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30177045 13 COSMIC
COSN2531319 37 COSMIC
COSN28739626 42 COSMIC
COSN15661146 56 COSMIC
COSN31597094 61 COSMIC
COSN31489952 70 COSMIC
COSN30541841 106 COSMIC
COSN30117157 113 COSMIC
COSN31536401 116 COSMIC
COSN30120270 136 COSMIC
COSN30529091 186 COSMIC
COSN30177094 198 COSMIC
COSN30177072 207 COSMIC
COSN31596030 248 COSMIC
COSN31558038 258 COSMIC
COSN31491824 293 COSMIC
COSN30131369 297 COSMIC
COSN31479647 326 COSMIC
COSN20993407 336 COSMIC
COSN31498583 343 COSMIC
COSN30191492 348 COSMIC
COSN31538984 351 COSMIC
COSN31614233 352 COSMIC
COSN30449069 366 COSMIC
COSN31575802 372 COSMIC
COSN30170024 375 COSMIC
COSN30463949 383 COSMIC
COSN30166123 412 COSMIC
COSN31529162 425 COSMIC
COSN30494822 427 COSMIC
COSN13977384 428 COSMIC
COSN31527154 440 COSMIC
COSN30526623 447 COSMIC
COSN26465992 448 COSMIC
COSN30488188 466 COSMIC
COSN2382265 473 COSMIC
COSN26669853 484 COSMIC
COSN31579391 494 COSMIC
COSN20681087 508 COSMIC
COSN30497157 517 COSMIC
COSN30453199 532 COSMIC
COSN28886994 544 COSMIC
COSN31492275 549 COSMIC
COSN26990916 556 COSMIC
COSN31548515 556 COSMIC
COSN24397639 565 COSMIC
COSN13977392 568 COSMIC
COSN26990917 572 COSMIC
COSN18726904 577 COSMIC
COSN2534311 577 COSMIC
COSN30525953 578 COSMIC
COSN18726905 579 COSMIC
COSN31524785 592 COSMIC
COSN26990920 613 COSMIC
COSN26990919 615 COSMIC
COSN31568093 618 COSMIC
COSN26676877 630 COSMIC
COSN30490222 634 COSMIC
COSN30528967 675 COSMIC
COSN30173902 676 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1222878604 1 dbSNP
rs921794203 3 dbSNP
rs1286128329 4 dbSNP
rs1197567819 6 dbSNP
rs1199414248 6 dbSNP
rs1491243450 11 dbSNP
rs753400853 12 dbSNP
rs1487783999 13 dbSNP
rs768026663 14 dbSNP
rs750767589 16 dbSNP
rs1269303790 17 dbSNP
rs760419505 18 dbSNP
rs1054738751 19 dbSNP
rs1208370468 20 dbSNP
rs1239608494 24 dbSNP
rs1293930360 26 dbSNP
rs1369607640 26 dbSNP
rs1429710829 26 dbSNP
rs368863947 26 dbSNP
rs756999912 26 dbSNP
rs766063352 26 dbSNP
rs753427430 27 dbSNP
rs750184715 30 dbSNP
rs754572320 32 dbSNP
rs778264619 34 dbSNP
rs563464274 36 dbSNP
rs758273484 37 dbSNP
rs62197232 39 dbSNP
rs931789374 41 dbSNP
rs758287487 42 dbSNP
rs777564345 44 dbSNP
rs13022221 45 dbSNP
rs1431978194 45 dbSNP
rs1177908478 46 dbSNP
rs1359505446 52 dbSNP
rs1427809644 52 dbSNP
rs1450287590 56 dbSNP
rs1192153372 58 dbSNP
rs1198424169 61 dbSNP
rs1246567780 66 dbSNP
rs13400325 67 dbSNP
rs1479136855 68 dbSNP
rs1041750949 69 dbSNP
rs11266766 70 dbSNP
rs11558923 71 dbSNP
rs1230390514 74 dbSNP
rs1313906697 77 dbSNP
rs1301829024 80 dbSNP
rs1213781417 85 dbSNP
rs896153147 86 dbSNP
rs1003301928 94 dbSNP
rs1389666480 96 dbSNP
rs1302359196 97 dbSNP
rs1464556769 97 dbSNP
rs1014495315 98 dbSNP
rs1056687516 105 dbSNP
rs1045949744 107 dbSNP
rs906066335 109 dbSNP
rs1002087988 111 dbSNP
rs1449736088 112 dbSNP
rs548945335 115 dbSNP
rs1027753837 116 dbSNP
rs1256071818 117 dbSNP
rs1203805154 120 dbSNP
rs932801563 120 dbSNP
rs952195691 122 dbSNP
rs1004885688 123 dbSNP
rs1366216962 124 dbSNP
rs13022261 127 dbSNP
rs1014970982 133 dbSNP
rs567478080 136 dbSNP
rs976023502 138 dbSNP
rs62197233 139 dbSNP
rs757524887 147 dbSNP
rs953256276 149 dbSNP
rs979646609 150 dbSNP
rs1277479483 151 dbSNP
rs975859842 152 dbSNP
rs925064686 153 dbSNP
rs1367537400 155 dbSNP
rs1185051521 156 dbSNP
rs1209560544 158 dbSNP
rs1425174823 167 dbSNP
rs922078928 176 dbSNP
rs1268504808 180 dbSNP
rs1180787095 187 dbSNP
rs1453506410 190 dbSNP
rs1186937726 198 dbSNP
rs3855570 199 dbSNP
rs539522846 203 dbSNP
rs1358546229 204 dbSNP
rs1263439384 205 dbSNP
rs1242941657 207 dbSNP
rs935116188 208 dbSNP
rs1342451991 214 dbSNP
rs1313565923 216 dbSNP
rs1169134174 223 dbSNP
rs746302260 224 dbSNP
rs1052183637 225 dbSNP
rs917612129 227 dbSNP
rs1456341875 228 dbSNP
rs4017855 228 dbSNP
rs558959660 228 dbSNP
rs546739843 229 dbSNP
rs571225495 239 dbSNP
rs112478714 242 dbSNP
rs1162361990 246 dbSNP
rs1391224456 249 dbSNP
rs35194787 249 dbSNP
rs949039468 251 dbSNP
rs1368645116 259 dbSNP
rs4017856 259 dbSNP
rs1157789108 265 dbSNP
rs1471285982 265 dbSNP
rs538669189 266 dbSNP
rs558405680 267 dbSNP
rs576708677 275 dbSNP
rs1182879803 276 dbSNP
rs1450938990 279 dbSNP
rs1442586503 282 dbSNP
rs575637532 282 dbSNP
rs1211367083 283 dbSNP
rs1358763594 287 dbSNP
rs1273987184 289 dbSNP
rs1045983455 293 dbSNP
rs537760044 295 dbSNP
rs1318181644 299 dbSNP
rs1327247842 302 dbSNP
rs1290279890 306 dbSNP
rs1411028348 306 dbSNP
rs1363826683 307 dbSNP
rs13022669 309 dbSNP
rs1322024312 317 dbSNP
rs201291591 317 dbSNP
rs1388829067 318 dbSNP
rs1391008153 323 dbSNP
rs1319550916 325 dbSNP
rs906097546 325 dbSNP
rs181944599 331 dbSNP
rs13022849 332 dbSNP
rs1060635 334 dbSNP
rs1001720763 347 dbSNP
rs1049658179 351 dbSNP
rs1477672273 351 dbSNP
rs887947467 352 dbSNP
rs1244745552 356 dbSNP
rs1005408919 357 dbSNP
rs1247180467 358 dbSNP
rs1015002114 364 dbSNP
rs1208411345 366 dbSNP
rs186289669 373 dbSNP
rs938748360 380 dbSNP
rs1224369702 393 dbSNP
rs1055923400 396 dbSNP
rs1273517959 402 dbSNP
rs894964272 403 dbSNP
rs541095679 405 dbSNP
rs997495771 406 dbSNP
rs1465388965 407 dbSNP
rs1190522789 408 dbSNP
rs1432496741 413 dbSNP
rs1028928039 416 dbSNP
rs1390331343 417 dbSNP
rs1234032040 419 dbSNP
rs1320663807 419 dbSNP
rs1413347047 419 dbSNP
rs746745843 422 dbSNP
rs780099479 424 dbSNP
rs1197364815 426 dbSNP
rs770711299 427 dbSNP
rs953384018 428 dbSNP
rs780315435 429 dbSNP
rs746991146 430 dbSNP
rs553084590 432 dbSNP
rs769741804 432 dbSNP
rs1431486319 433 dbSNP
rs777952470 433 dbSNP
rs749469868 437 dbSNP
rs771204040 438 dbSNP
rs3856532 440 dbSNP
rs774256901 441 dbSNP
rs774573704 445 dbSNP
rs979291369 446 dbSNP
rs1272685086 450 dbSNP
rs748711725 451 dbSNP
rs773718718 454 dbSNP
rs759850417 456 dbSNP
rs772444011 458 dbSNP
rs775951856 461 dbSNP
rs761186811 463 dbSNP
rs371875640 464 dbSNP
rs776394835 467 dbSNP
rs577593108 472 dbSNP
rs764831440 473 dbSNP
rs1411518859 475 dbSNP
rs1301934404 476 dbSNP
rs865776287 477 dbSNP
rs761281623 487 dbSNP
rs1349189726 488 dbSNP
rs545120772 488 dbSNP
rs763506886 488 dbSNP
rs776261091 488 dbSNP
rs563591878 489 dbSNP
rs763948802 491 dbSNP
rs751487975 493 dbSNP
rs1014587787 495 dbSNP
rs761243201 496 dbSNP
rs757095516 497 dbSNP
rs780823188 500 dbSNP
rs749559346 501 dbSNP
rs1289487407 504 dbSNP
rs755107666 508 dbSNP
rs779064314 510 dbSNP
rs764914643 511 dbSNP
rs1448793196 514 dbSNP
rs375182075 516 dbSNP
rs772274590 517 dbSNP
rs1449900758 519 dbSNP
rs773912926 521 dbSNP
rs747494804 523 dbSNP
rs1335599870 524 dbSNP
rs1388214106 524 dbSNP
rs1406585694 526 dbSNP
rs750131903 527 dbSNP
rs771462716 527 dbSNP
rs1323651691 530 dbSNP
rs530674898 531 dbSNP
rs1435043807 535 dbSNP
rs369231484 538 dbSNP
rs1431343886 539 dbSNP
rs542909883 539 dbSNP
rs1229695630 553 dbSNP
rs775067075 556 dbSNP
rs762510360 557 dbSNP
rs763575126 560 dbSNP
rs757150586 564 dbSNP
rs767368552 566 dbSNP
rs1390554544 567 dbSNP
rs953637619 567 dbSNP
rs1189656540 568 dbSNP
rs1235845041 568 dbSNP
rs371651937 568 dbSNP
rs750128516 568 dbSNP
rs758218401 568 dbSNP
rs755235375 569 dbSNP
rs779072251 570 dbSNP
rs1203457785 572 dbSNP
rs748365825 573 dbSNP
rs758597952 577 dbSNP
rs777968490 578 dbSNP
rs766327879 579 dbSNP
rs747548334 581 dbSNP
rs967617922 585 dbSNP
rs1490338087 586 dbSNP
rs780435249 588 dbSNP
rs201368548 590 dbSNP
rs1414814878 593 dbSNP
rs1163284028 595 dbSNP
rs1370990951 600 dbSNP
rs1163770015 601 dbSNP
rs1232309526 605 dbSNP
rs977666615 605 dbSNP
rs927549599 606 dbSNP
rs1476154934 617 dbSNP
rs1179664256 626 dbSNP
rs151332616 635 dbSNP
rs937632347 636 dbSNP
rs1232300378 640 dbSNP
rs928637017 640 dbSNP
rs1475536296 644 dbSNP
rs1251170026 645 dbSNP
rs1180722789 648 dbSNP
rs938717375 656 dbSNP
rs1233861455 662 dbSNP
rs991946232 663 dbSNP
rs1411004995 677 dbSNP
rs1449539208 684 dbSNP
rs1472688424 685 dbSNP
rs1049312415 691 dbSNP
rs554443093 693 dbSNP
rs528310965 697 dbSNP
rs1160904556 700 dbSNP
rs1233370940 701 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545212. RNA binding protein: AGO1. Condition:Control PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 5757.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065669. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM4903825
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID14_NS
Location of target site NM_002823 | 3UTR | AGAAUCUAAACGUGGUCACCUUCGAGUAGAGAGGCCCGCCCGCCCACCGUGGGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903826
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / PID21_NS
Location of target site NM_001099285 | 3UTR | AAACGUGGUCACCUUCGAGUAGAGAGGCCCGCCCGCCCACCGUGGGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161237
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_001099285 | 3UTR | AACGUGGUCACCUUCGAGUAGAGAGGCCCGCCCGCCCACCGUGGGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903834
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_b
Location of target site NM_002823 | 3UTR | CAAAAAAGGAAAAGUUAAACUAAAAAAAAAAAGGCCGCCGUGACCUAUUCACCCUCCACUUCCCGUCUCAGAAUCUAAACGUGGUCACCUUCGAGUAGAGAGGCCCGCCCGCCCACCGUGGGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_002823 | 3UTR | UAAACGUGGUCACCUUCGAGUAGAGAGGCCCGCCCGCCCACCGUGGGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_002823 | 3UTR | GCAAAAAAGGAAAAGUUAAACUAAAAAAAAAAAGGCCGCCGUGACCUAUUCACCCUCCACUUCCCGUCUCAGAAUCUAAACGUGGUCACCUUCGAGUAGAGAGGCCCGCCCGCCCACCGUGGGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 7 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_001099285 | 3UTR | CUAAACGUGGUCACCUUCGAGUAGAGAGGCCCGCCCGCCCACCGUGGGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 8 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_002823 | 3UTR | UAAACGUGGUCACCUUCGAGUAGAGAGGCCCGCCCGCCCACCGUGGGCA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 9 for dataset GSM545212
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / Control
Location of target site ENST00000409115.3 | 3UTR | CCGCCGUGACCUAUUCACCCUCCACUUCCCGUCUCAGAAUCUAAACGUGGUCACCUUC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 10 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000409115.3 | 3UTR | ACCUAUUCACCCUCCACUUCCCGUCUCAGAAUCUAAACGUGGUCACCUUCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 11 for dataset GSM1065669
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_8
Location of target site ENST00000409115.3 | 3UTR | CCGCCGUGACCUAUUCACCCUCCACUUCCCGUCUCAGAAUCUAAACGUGGUCACCUUCG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
56 hsa-miR-4760-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT076215 ALKBH5 alkB homolog 5, RNA demethylase 2 2
MIRT087763 H1F0 H1 histone family member 0 2 2
MIRT093991 SLAIN2 SLAIN motif family member 2 2 2
MIRT109199 VMA21 VMA21, vacuolar ATPase assembly factor 2 4
MIRT243167 SOX11 SRY-box 11 2 2
MIRT290697 POLI DNA polymerase iota 2 2
MIRT352597 PTMA prothymosin, alpha 2 4
MIRT443107 DENND5B DENN domain containing 5B 2 2
MIRT445651 ATP6V1G1 ATPase H+ transporting V1 subunit G1 2 6
MIRT449111 PHEX phosphate regulating endopeptidase homolog X-linked 2 2
MIRT449798 ZNF74 zinc finger protein 74 2 2
MIRT456143 RWDD2A RWD domain containing 2A 2 18
MIRT463303 ZFP36L1 ZFP36 ring finger protein like 1 2 6
MIRT466904 STK38 serine/threonine kinase 38 2 10
MIRT492452 RBPJ recombination signal binding protein for immunoglobulin kappa J region 2 8
MIRT511574 HIST2H3D histone cluster 2 H3 family member d 2 4
MIRT519374 FKBP14 FK506 binding protein 14 2 2
MIRT520935 SRSF4 serine and arginine rich splicing factor 4 2 4
MIRT524345 CREB1 cAMP responsive element binding protein 1 2 2
MIRT530230 WSB2 WD repeat and SOCS box containing 2 2 2
MIRT531864 POF1B premature ovarian failure, 1B 2 2
MIRT534916 PTPN4 protein tyrosine phosphatase, non-receptor type 4 2 2
MIRT536707 IKZF2 IKAROS family zinc finger 2 2 2
MIRT543555 RPF2 ribosome production factor 2 homolog 2 4
MIRT545247 GTF2E1 general transcription factor IIE subunit 1 2 2
MIRT545376 PM20D2 peptidase M20 domain containing 2 2 2
MIRT548107 GDAP2 ganglioside induced differentiation associated protein 2 2 2
MIRT548301 EPHA7 EPH receptor A7 2 2
MIRT551453 CARKD NAD(P)HX dehydratase 2 2
MIRT553195 UBE2A ubiquitin conjugating enzyme E2 A 2 2
MIRT559416 ASH1L ASH1 like histone lysine methyltransferase 2 2
MIRT561360 YOD1 YOD1 deubiquitinase 2 2
MIRT561380 TWF1 twinfilin actin binding protein 1 2 2
MIRT562062 KLHL15 kelch like family member 15 2 2
MIRT563482 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT563510 APOOL apolipoprotein O like 2 2
MIRT571391 MRPL19 mitochondrial ribosomal protein L19 2 2
MIRT573764 PRKAG1 protein kinase AMP-activated non-catalytic subunit gamma 1 2 2
MIRT576963 Anxa4 annexin A4 2 3
MIRT611048 DAB2 DAB2, clathrin adaptor protein 2 2
MIRT614297 ARL6IP6 ADP ribosylation factor like GTPase 6 interacting protein 6 2 2
MIRT619715 FCF1 FCF1, rRNA-processing protein 2 2
MIRT622278 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT622624 PPM1K protein phosphatase, Mg2+/Mn2+ dependent 1K 2 2
MIRT624730 ANXA4 annexin A4 2 3
MIRT626553 ZYG11B zyg-11 family member B, cell cycle regulator 2 2
MIRT649762 USP22 ubiquitin specific peptidase 22 2 2
MIRT652063 TTC39B tetratricopeptide repeat domain 39B 2 2
MIRT653045 STON2 stonin 2 2 2
MIRT660573 AQR aquarius intron-binding spliceosomal factor 2 2
MIRT686243 ZFR zinc finger RNA binding protein 2 2
MIRT703405 FZD6 frizzled class receptor 6 2 2
MIRT709480 LOXL2 lysyl oxidase like 2 2 2
MIRT711268 SDR9C7 short chain dehydrogenase/reductase family 9C member 7 2 2
MIRT711426 PROSER2 proline and serine rich 2 2 2
MIRT720030 CDK13 cyclin dependent kinase 13 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4760 Paclitaxel 36314 NSC125973 approved sensitive cell line (W1)
hsa-miR-4760-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)

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