miRTarBase - #MIRT357963


—
pre-miRNA Information
pre-miRNA hsa-mir-2116   
Genomic Coordinates chr15: 59171183 - 59171262
Description Homo sapiens miR-2116 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-2116-5p
Sequence 14| GGUUCUUAGCAUAGGAGGUCU |34
Evidence Experimental
Experiments 454
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 8 15 - 59171242 29233923 MiREDiBase
A-to-I 13 15 - 59171237 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1217966510 1 dbSNP
rs1170901508 3 dbSNP
rs1364783161 5 dbSNP
rs1240890962 11 dbSNP
rs537360898 13 dbSNP
rs776323490 17 dbSNP
Putative Targets

Gene Information
Gene Symbol GRPEL2   
Synonyms Mt-GrpE#2
Description GrpE like 2, mitochondrial
Transcript NM_152407   
Expression
Putative miRNA Targets on GRPEL2
3'UTR of GRPEL2
(miRNA target sites are highlighted)		 
>GRPEL2|NM_152407|3'UTR
   1 AGAGGCCATCAGGAACTGGATGTTCTCCCAGAGCGCAGTCACCTATGTTTCTTTTATTTATTAAACTAGGTTTGTATTGT
  81 ACATGAGGTACTTCATGTGATATGTTTTGGATTTAGTCATATTGGCTTTATTTCTAAGATATTCTATTGATTTAATGTGA
 161 CCTGTTTGGTCTCATCAGAAGTCTTACCATTGGGCATTTGAACAGTGTGACAGGTGTTCCAATGGCCTTTATCAAAACAT
 241 GTTTAGGAAAATTGGTACTGTGATAAATTTGAATCCAAAATCCTTTTAACTATGGGTTTTCAACTACATGTTTCTTCCTA
 321 GCGGTCTCTATAACAGGAATTGTGTAGTATCTTGTATTTTGTGGAAAAAGGAGATGGTAGGGATTGGTTCAACATTTGGG
 401 TACTTAGAGGATAAAGCTTCGTGGTCGTATAAATTTAGATCATTTGGATTGATTTTTATACACATAGATTTTCAGGACTT
 481 TACCTTTTGTTTTGTTTTTTTCCTTTTAGCCATCTTTTGTTCTTGTAATCCCAACTAGATAGGCTTTATGCTCACATCAT
 561 TGTCCCATACCCACCCCTTTCTCATCCCCATTTGCAGGGGCTAAAGGTCTAGATGAGACTTGGAAGGCAAGGAGCATCGA
 641 AATTTGAGATACCCAGGACCCTTTCAAGCAAGAATGGCCAAAAAGCCTTGTGCTGTCTTTGCTCTTCAAATTATTTTCAG
 721 CCTCCTTGTCATATAATCATTTCAGGCAAACTGAGGCAACACTAACAGCTAATGACCCAGATGGCTCTATTTGGGTAATT
 801 TACCTACAACTTATTCCACCAGCCTTTACTCCTCTGCCCTTTTGTCAATTTTACCTTATAATCCTTTATTAAATGATGGG
 881 AGGTGGTGATCAGGACAAAAGTGTTAGGTTCCCATGATTTCTCATTTCATTTATTAATAGTTAATGCTGAATTTTTTTTT
 961 AAGTTTCCTCTGGCTCTATTTATGTTACTTTTTGCGATAAGAACACTTAACATAAGTATTCTCTCCTCTTGGCAATTTTT
1041 TTTTTTTTTCCTGTGTTGCCCAGGCTGACCTCCAACTCCTGGGCCCAAGCAATCCTGCCTCAGCCTGCCAAGTAGCTAGG
1121 ACTACAGGCGTTCACCACTGCGCCCGCAAAGTTTTTTTGTTGTTTTTTTTTTTAAGTTGGTACTCACAAATCACTACCTC
1201 TGTTATATTGACAAGCTCTATTTCCTATTCTTTGTATCTGTTAAGTCACATCTGTGTAAACATTGAGCTCACCTTTTATA
1281 TATTAACCTCTAGAATTAATGGGCCTATGTGGTTTTTTTTCAGTCTTATAGCTGGTGTTCTGTAAAAGATTTGTCCAATA
1361 AACGACTTAATGAATGATACATCAGTCAGATTTTAGGAAGGCAGTCAATTATGGATATTTTAATGTTGGAAGAGGCCTTA
1441 ATGATCAAATCTCACCCTTTCTGCTTCTGAAGTATGAAAATCTAGTCTTTTTAGGACTGGACACAAGGAAAATAATCTCT
1521 AAACTATTGACTAAATTCCAGTGAGAGTATGAATGAAGAACAACTAGATATTAATGTCAATCATTTAAGATTAATGGGCA
1601 TGCAATTAAGTCTCCATTTAAGATTAATGGGCATGCAATGAAGTCTCCAGCAGACAATCAGATGTTGTTGGATGTCTAGA
1681 TTATATAGGTTTAGGTTGAAGTTATAAAATAAAATAAAATTCATTTTCCACTGGAACTCTATGACATTCAGTGGAGTGGT
1761 GGAAAGTTAACCTCTTATACATTATAGATAATTCTAAGACAGCACACAAACTTATCAATAAAGCCATCTCCTTGTGGGCC
1841 TTACCATCTTCATCAGATTTAGACCCTTAAAAAACAAGTAAATATGCACTTTTAAAATGCAATCAAAAGACTGGTGGTTA
1921 AGCTTGTAAAACCAGAACATCTTTTGGCATTCCACTAAGTATATATTGTAAATTTAATGAACAATCAAGGTTCACAATAG
2001 GAAGTTGTCTTTTTTTGCCTTCCATTCTGTGAGATTTGACAGATGGTGACAATAAGAAAATGAGCTGATTGTAATTACTC
2081 TCTGTGTGTTTTTTTATTGCTAGCTATCATTACCAGTTAGAATTAACATTAATTACAATTAACAATAATTTTAGGTATGG
2161 AATGTTATGATTACCTAAAGAGATGTCTCTACCTAATGAGCTCAAGTGATCCTCCCACCTCAGCCTACCAAGTAGCCAGG
2241 ACCACAGGCAAGTGCACCACCATGACTGGCTAGTTTTGTTTTTTGGTTTTTGGTTTTTGGTTTTTGGTTTTTTTTTTTTG
2321 GTTGGTTGGTTGTTTTTTACAGGCGGGGTCTCACTATATTGTCCAGGCTAGAAGAATTTTCTAATGGTCTATTACACCTC
2401 CCGTTTTGGCAAGTAAATTCAGAATAATTTTAGGTTCTTTTGTTATTCAGTAGTTTTGCAGACTTAAAAGTGTAAATTTA
2481 GAATTAGAAGATGAAGCTATAGTAGTAAGAATCTCAAGCTGAAGGGCTTTGGGGAGCCAAAGCAGCATATTAGAGCATAG
2561 GCTTGAACTTAAATCTCAGCTCAGTCACCTGCAGGACTTTAGGCACCAGTGATTTCACCCTTCTGAGCCTGTTTCTTTAT
2641 TCGTAAAATGATTATAATAATTCTTTCACAGCGTTGTGAGGATTAAGTGAAATGTGTTAAATGCCTACTACAGTAGGTGC
2721 TCAGATATTTATTTTTATTTTTTTATTATGCACATTGTTTTTCCTGCCTTTTTATGGCTGTCTAAAGTCTAGGGAAAAGG
2801 GAAGACTGGTTAATGATGAGTAGAAAAAACTTGTAAGCTAATCATTCACTGACTTATTTTCCTTCCATTTTCTGGTTTTT
2881 AAAATTAGCCACACCACAGGAAACCCACATTTTTAGATGGAAAGAGCAAGAAAATTGTGTCAGTGCTCTTAGTTATTTTC
2961 ATCTTAATGGTATAGTGAAAAGACATTGACTTGAGATGATACTAAGGAAGCTTTGGCTCACTCTCACTTGAAGAGGGGAT
3041 CTTGGTGTTGTAGTACTTGGACTGTACAAATGTTTTACTGACTTTTCTTACTGCTGTAAAGGAATCAGGCAGTTGGGTAT
3121 TGATATGTTATTTGGTGCTCTCATTCATGGCAAAGGATTTGATAAATAAAAGTTCTTTAAACACTAAAGCAAAATCAAAT
3201 GAGCAAAACTAAGGATGAAATGTAATATTCATCAGAACAAGGATCACTGAGAAAAAATATTCAGAAACAACTTTAATAAA
3281 ACCTGAATTGAAATAACTGCA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucUGGAGGAUACGAUUCUUGg 5'
            ||:|::|: | ||||||| 
Target 5' ttACTTTTTGCGATAAGAACa 3'
 985 - 1005 163.00 -12.40
2 
miRNA  3' ucuggagGAUA-CG--AUUCUUGg 5'
                 |||| |:  ||||||: 
Target 5' gatgaagCTATAGTAGTAAGAATc 3'
 2490 - 2513 132.00 -8.50
3 
miRNA  3' ucuggaggauacgaUUCUUGg 5'
                        |||||| 
Target 5' tgagagtatgaatgAAGAACa 3'
 1542 - 1562 120.00 -8.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM5746491 1 COSMIC
COSN26978178 6 COSMIC
COSN31587096 7 COSMIC
COSN8492059 32 COSMIC
COSN26553431 36 COSMIC
COSN30509503 41 COSMIC
COSN31593230 42 COSMIC
COSN30521448 53 COSMIC
COSN30470862 63 COSMIC
COSN6867427 77 COSMIC
COSN31610305 134 COSMIC
COSN23266700 158 COSMIC
COSN28198219 319 COSMIC
COSN25030709 390 COSMIC
COSN29875747 422 COSMIC
COSN9411078 442 COSMIC
COSN29318470 835 COSMIC
COSN20102035 1174 COSMIC
COSN32063383 1239 COSMIC
COSN16130464 1683 COSMIC
COSN19664353 1791 COSMIC
COSN31585003 1871 COSMIC
COSN26644589 1876 COSMIC
COSN31585867 1975 COSMIC
COSN19390539 2141 COSMIC
COSN27311332 2320 COSMIC
COSN6867428 2342 COSMIC
COSN27905154 2854 COSMIC
COSN23425796 3046 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs755997296 5 dbSNP
rs778576589 6 dbSNP
rs1257838800 12 dbSNP
rs1412719754 14 dbSNP
rs777339259 18 dbSNP
rs1212503643 24 dbSNP
rs753227310 24 dbSNP
rs756955013 25 dbSNP
rs1429149941 26 dbSNP
rs778495465 29 dbSNP
rs745489024 32 dbSNP
rs200331421 35 dbSNP
rs780384770 36 dbSNP
rs1366365363 41 dbSNP
rs779794013 43 dbSNP
rs1299321486 44 dbSNP
rs546964513 46 dbSNP
rs1189183865 47 dbSNP
rs1055232403 48 dbSNP
rs571253937 48 dbSNP
rs1194758264 49 dbSNP
rs1396878077 53 dbSNP
rs747704267 53 dbSNP
rs896140567 62 dbSNP
rs1171925474 63 dbSNP
rs1431691268 71 dbSNP
rs1390973886 80 dbSNP
rs1432986005 88 dbSNP
rs375529106 88 dbSNP
rs538639295 92 dbSNP
rs1474320429 94 dbSNP
rs1238934642 101 dbSNP
rs1036798388 106 dbSNP
rs1287102754 119 dbSNP
rs143986195 147 dbSNP
rs1027787880 166 dbSNP
rs1396393131 175 dbSNP
rs188254387 182 dbSNP
rs1332248700 186 dbSNP
rs182035095 191 dbSNP
rs1268338992 192 dbSNP
rs773784789 195 dbSNP
rs1330687596 196 dbSNP
rs1018052760 202 dbSNP
rs1355125673 208 dbSNP
rs966053711 217 dbSNP
rs1242059430 224 dbSNP
rs976032694 226 dbSNP
rs748088194 233 dbSNP
rs1483826793 240 dbSNP
rs1415870550 242 dbSNP
rs184828053 245 dbSNP
rs1163685803 261 dbSNP
rs1021009484 263 dbSNP
rs966725783 268 dbSNP
rs1254451617 284 dbSNP
rs1183845846 292 dbSNP
rs1472646836 296 dbSNP
rs1231862045 299 dbSNP
rs540520017 305 dbSNP
rs1436644161 306 dbSNP
rs1475066997 314 dbSNP
rs1160265465 322 dbSNP
rs1292629960 323 dbSNP
rs771970855 324 dbSNP
rs565274471 331 dbSNP
rs917801373 343 dbSNP
rs189160051 350 dbSNP
rs1374297772 351 dbSNP
rs1279110202 357 dbSNP
rs1440099223 360 dbSNP
rs1455723320 362 dbSNP
rs1158389081 365 dbSNP
rs1324056057 368 dbSNP
rs783777 374 dbSNP
rs1466439642 400 dbSNP
rs1036664368 401 dbSNP
rs139889678 404 dbSNP
rs1353374529 408 dbSNP
rs1413941111 413 dbSNP
rs1478691517 418 dbSNP
rs1288657215 421 dbSNP
rs143254560 422 dbSNP
rs1468333396 427 dbSNP
rs1049730385 428 dbSNP
rs1210935007 437 dbSNP
rs1317811345 448 dbSNP
rs766168650 462 dbSNP
rs376085554 466 dbSNP
rs1212908221 467 dbSNP
rs1304099543 468 dbSNP
rs1440144388 472 dbSNP
rs1254760791 485 dbSNP
rs1322373669 495 dbSNP
rs548730958 498 dbSNP
rs561061130 508 dbSNP
rs902075768 518 dbSNP
rs997481891 519 dbSNP
rs146191751 525 dbSNP
rs1471708280 535 dbSNP
rs966799891 540 dbSNP
rs1251669511 545 dbSNP
rs62378142 546 dbSNP
rs1032614083 547 dbSNP
rs1486361981 548 dbSNP
rs571568615 553 dbSNP
rs959251458 554 dbSNP
rs1314143324 556 dbSNP
rs1178234820 560 dbSNP
rs1373548627 563 dbSNP
rs35269240 568 dbSNP
rs1433887436 569 dbSNP
rs1299654772 575 dbSNP
rs1382575376 581 dbSNP
rs1360963229 584 dbSNP
rs1286773727 585 dbSNP
rs139120668 601 dbSNP
rs1308337255 603 dbSNP
rs1449835378 613 dbSNP
rs759696729 620 dbSNP
rs1372056596 622 dbSNP
rs1172546265 627 dbSNP
rs1432264621 635 dbSNP
rs1393817334 637 dbSNP
rs1439510367 639 dbSNP
rs991030582 643 dbSNP
rs1429509202 658 dbSNP
rs1419312811 671 dbSNP
rs1185111338 682 dbSNP
rs765333065 685 dbSNP
rs917847825 686 dbSNP
rs1258470389 689 dbSNP
rs1210270347 691 dbSNP
rs1367774110 703 dbSNP
rs970592264 710 dbSNP
rs1276729207 721 dbSNP
rs972434594 735 dbSNP
rs73795987 736 dbSNP
rs1229813885 748 dbSNP
rs1347709128 761 dbSNP
rs1355714992 768 dbSNP
rs752755364 772 dbSNP
rs1311830661 777 dbSNP
rs1412422275 798 dbSNP
rs758939113 800 dbSNP
rs1048127867 805 dbSNP
rs910938523 808 dbSNP
rs1354462274 810 dbSNP
rs1168853434 811 dbSNP
rs762854491 815 dbSNP
rs1187444077 824 dbSNP
rs902142675 825 dbSNP
rs1206349726 831 dbSNP
rs576389475 834 dbSNP
rs997715382 838 dbSNP
rs1480305102 840 dbSNP
rs1204137021 849 dbSNP
rs1247508903 855 dbSNP
rs1223504218 857 dbSNP
rs1335196192 865 dbSNP
rs1479083549 870 dbSNP
rs142492416 877 dbSNP
rs757627516 886 dbSNP
rs536320725 895 dbSNP
rs1453682720 925 dbSNP
rs879557089 929 dbSNP
rs1169013274 934 dbSNP
rs1307172711 938 dbSNP
rs1390300987 941 dbSNP
rs1396431355 943 dbSNP
rs1001248314 952 dbSNP
rs1032438452 952 dbSNP
rs1395609853 968 dbSNP
rs1164627063 981 dbSNP
rs1460106645 984 dbSNP
rs959686051 993 dbSNP
rs1407995040 996 dbSNP
rs1182692412 997 dbSNP
rs900344542 1006 dbSNP
rs1012082806 1008 dbSNP
rs370336945 1013 dbSNP
rs970669055 1020 dbSNP
rs972634035 1035 dbSNP
rs1189271753 1036 dbSNP
rs1330845526 1036 dbSNP
rs368880850 1036 dbSNP
rs1237705565 1050 dbSNP
rs1437992315 1051 dbSNP
rs918282444 1053 dbSNP
rs1370933189 1054 dbSNP
rs1229844561 1056 dbSNP
rs1300403755 1059 dbSNP
rs75701657 1062 dbSNP
rs878867392 1063 dbSNP
rs1439138672 1070 dbSNP
rs1387429721 1073 dbSNP
rs1159328284 1081 dbSNP
rs1453177363 1089 dbSNP
rs1214340883 1093 dbSNP
rs1362188273 1096 dbSNP
rs984164566 1105 dbSNP
rs1290881555 1108 dbSNP
rs1454709082 1109 dbSNP
rs1453479834 1110 dbSNP
rs910983276 1110 dbSNP
rs1448450794 1113 dbSNP
rs754626574 1130 dbSNP
rs566710798 1131 dbSNP
rs1348068140 1137 dbSNP
rs1257287857 1138 dbSNP
rs1211937131 1139 dbSNP
rs534131844 1142 dbSNP
rs1465386221 1143 dbSNP
rs151119231 1146 dbSNP
rs865849056 1147 dbSNP
rs933598146 1158 dbSNP
rs1381905534 1160 dbSNP
rs1383072817 1162 dbSNP
rs1373477409 1163 dbSNP
rs1394411609 1163 dbSNP
rs1476281608 1163 dbSNP
rs34012190 1163 dbSNP
rs397883206 1163 dbSNP
rs879127099 1163 dbSNP
rs1042637525 1164 dbSNP
rs1259161139 1166 dbSNP
rs1210994410 1175 dbSNP
rs1167038202 1181 dbSNP
rs1280269604 1184 dbSNP
rs1426148649 1187 dbSNP
rs1414106825 1188 dbSNP
rs1271206434 1198 dbSNP
rs902742701 1201 dbSNP
rs1162314207 1207 dbSNP
rs577484634 1209 dbSNP
rs1415512117 1217 dbSNP
rs1374873594 1220 dbSNP
rs181668726 1222 dbSNP
rs1411625747 1224 dbSNP
rs1397120139 1228 dbSNP
rs1167169081 1235 dbSNP
rs1474270326 1237 dbSNP
rs1419575799 1246 dbSNP
rs1054155817 1259 dbSNP
rs1414753742 1263 dbSNP
rs1474664421 1271 dbSNP
rs556501078 1279 dbSNP
rs1323210405 1283 dbSNP
rs1206002648 1287 dbSNP
rs1440117890 1288 dbSNP
rs895269676 1293 dbSNP
rs778482092 1303 dbSNP
rs1316408363 1304 dbSNP
rs1325142310 1308 dbSNP
rs1012738956 1313 dbSNP
rs201141949 1313 dbSNP
rs562816126 1313 dbSNP
rs1355022881 1314 dbSNP
rs1024844851 1319 dbSNP
rs1444447198 1325 dbSNP
rs761251805 1329 dbSNP
rs1336291017 1330 dbSNP
rs1430473559 1332 dbSNP
rs114111616 1338 dbSNP
rs993981097 1341 dbSNP
rs1025580884 1344 dbSNP
rs952704810 1344 dbSNP
rs1358768193 1359 dbSNP
rs542335769 1362 dbSNP
rs1415193039 1364 dbSNP
rs560578214 1365 dbSNP
rs1272750361 1368 dbSNP
rs1234001909 1369 dbSNP
rs1181662529 1381 dbSNP
rs1018348423 1387 dbSNP
rs773069903 1409 dbSNP
rs541423366 1413 dbSNP
rs1334512339 1419 dbSNP
rs1263767318 1420 dbSNP
rs963856697 1436 dbSNP
rs1351441224 1437 dbSNP
rs141073430 1444 dbSNP
rs559591418 1457 dbSNP
rs62378143 1462 dbSNP
rs531837689 1473 dbSNP
rs532419162 1476 dbSNP
rs1439823273 1483 dbSNP
rs1391849073 1486 dbSNP
rs1160794341 1488 dbSNP
rs1185434067 1501 dbSNP
rs1400807551 1508 dbSNP
rs1416702922 1509 dbSNP
rs544626252 1516 dbSNP
rs550628851 1516 dbSNP
rs1156270035 1517 dbSNP
rs1160657121 1527 dbSNP
rs924197120 1540 dbSNP
rs1194667687 1543 dbSNP
rs1468265502 1548 dbSNP
rs1383482966 1550 dbSNP
rs568830242 1552 dbSNP
rs1245231887 1554 dbSNP
rs1218151929 1556 dbSNP
rs936915171 1559 dbSNP
rs1283736086 1565 dbSNP
rs1053826678 1581 dbSNP
rs1303985743 1597 dbSNP
rs529695355 1599 dbSNP
rs1233337734 1600 dbSNP
rs547838334 1629 dbSNP
rs566230766 1633 dbSNP
rs895126497 1638 dbSNP
rs1342678955 1639 dbSNP
rs551547611 1641 dbSNP
rs1344230104 1643 dbSNP
rs1295867412 1649 dbSNP
rs569883590 1656 dbSNP
rs1435975424 1660 dbSNP
rs1292918332 1662 dbSNP
rs1046537939 1675 dbSNP
rs1454124135 1683 dbSNP
rs1351267790 1689 dbSNP
rs906587028 1695 dbSNP
rs1241686582 1697 dbSNP
rs139144586 1704 dbSNP
rs367795505 1704 dbSNP
rs533508892 1704 dbSNP
rs1025445059 1705 dbSNP
rs1210142071 1706 dbSNP
rs1258988484 1712 dbSNP
rs1310333482 1716 dbSNP
rs1297537644 1735 dbSNP
rs1350012089 1740 dbSNP
rs776933518 1742 dbSNP
rs888410953 1746 dbSNP
rs1416121944 1759 dbSNP
rs1005868355 1760 dbSNP
rs1017962330 1775 dbSNP
rs1311721209 1775 dbSNP
rs1357915913 1779 dbSNP
rs1173006550 1782 dbSNP
rs1486561469 1786 dbSNP
rs776456867 1789 dbSNP
rs1191721618 1797 dbSNP
rs976359434 1806 dbSNP
rs1029372799 1808 dbSNP
rs1187300976 1810 dbSNP
rs1472693433 1812 dbSNP
rs1482267682 1819 dbSNP
rs967059333 1821 dbSNP
rs3210763 1831 dbSNP
rs978267869 1833 dbSNP
rs534095136 1835 dbSNP
rs186391722 1840 dbSNP
rs1234800694 1846 dbSNP
rs924095430 1852 dbSNP
rs1292201327 1853 dbSNP
rs1173745236 1861 dbSNP
rs1377735919 1866 dbSNP
rs1393733902 1881 dbSNP
rs149837990 1886 dbSNP
rs1300379072 1901 dbSNP
rs1312609897 1903 dbSNP
rs990123110 1904 dbSNP
rs1168948701 1905 dbSNP
rs1007942038 1915 dbSNP
rs1019468030 1917 dbSNP
rs759769100 1925 dbSNP
rs1411955662 1926 dbSNP
rs780555296 1943 dbSNP
rs963845254 1956 dbSNP
rs1186944192 1957 dbSNP
rs764471194 1957 dbSNP
rs1422059428 1958 dbSNP
rs916817354 1960 dbSNP
rs1177663072 1962 dbSNP
rs1335315571 1976 dbSNP
rs996785920 1984 dbSNP
rs948065375 1987 dbSNP
rs1215321104 1990 dbSNP
rs1021568399 1992 dbSNP
rs538529742 1994 dbSNP
rs1272072994 1999 dbSNP
rs1234036364 2000 dbSNP
rs928038049 2006 dbSNP
rs1275383661 2010 dbSNP
rs1307065983 2017 dbSNP
rs1392523087 2028 dbSNP
rs755655234 2032 dbSNP
rs556626495 2037 dbSNP
rs574736974 2040 dbSNP
rs930043799 2043 dbSNP
rs1443487680 2047 dbSNP
rs1451153674 2052 dbSNP
rs1046966516 2056 dbSNP
rs1162845747 2061 dbSNP
rs923895946 2063 dbSNP
rs1365657274 2066 dbSNP
rs754307890 2070 dbSNP
rs1439073345 2077 dbSNP
rs1195271792 2078 dbSNP
rs1378345805 2078 dbSNP
rs1468719834 2081 dbSNP
rs779229379 2083 dbSNP
rs956794161 2085 dbSNP
rs191245991 2091 dbSNP
rs1260876915 2097 dbSNP
rs1029280606 2098 dbSNP
rs1353635577 2109 dbSNP
rs554279148 2115 dbSNP
rs1247974791 2117 dbSNP
rs1436782352 2119 dbSNP
rs1198868646 2133 dbSNP
rs948246136 2136 dbSNP
rs1323282668 2143 dbSNP
rs981334727 2158 dbSNP
rs1385349149 2159 dbSNP
rs1031194036 2163 dbSNP
rs1397461101 2164 dbSNP
rs1289538568 2169 dbSNP
rs1419104068 2177 dbSNP
rs920222800 2199 dbSNP
rs1453065039 2201 dbSNP
rs931554979 2202 dbSNP
rs181273523 2204 dbSNP
rs1046730341 2214 dbSNP
rs1376902286 2217 dbSNP
rs989635894 2230 dbSNP
rs1429996401 2234 dbSNP
rs1261921330 2237 dbSNP
rs886742131 2246 dbSNP
rs546353929 2247 dbSNP
rs1486997674 2248 dbSNP
rs1284528426 2259 dbSNP
rs1040794496 2267 dbSNP
rs565068837 2270 dbSNP
rs1296721869 2274 dbSNP
rs1231452067 2278 dbSNP
rs1296518044 2280 dbSNP
rs1328431416 2280 dbSNP
rs375919640 2280 dbSNP
rs546763534 2280 dbSNP
rs560324722 2280 dbSNP
rs996722917 2281 dbSNP
rs1314799753 2286 dbSNP
rs1021872093 2287 dbSNP
rs904440481 2294 dbSNP
rs924417332 2294 dbSNP
rs1387434561 2295 dbSNP
rs1463266673 2295 dbSNP
rs1325567862 2299 dbSNP
rs369606584 2299 dbSNP
rs999142310 2300 dbSNP
rs1031013307 2301 dbSNP
rs560411640 2301 dbSNP
rs1232054606 2302 dbSNP
rs1302554542 2304 dbSNP
rs1259051898 2305 dbSNP
rs375328285 2306 dbSNP
rs927944817 2306 dbSNP
rs1229326295 2307 dbSNP
rs6875079 2307 dbSNP
rs529101108 2308 dbSNP
rs6875080 2308 dbSNP
rs748382745 2308 dbSNP
rs548736231 2309 dbSNP
rs992101790 2309 dbSNP
rs930067035 2310 dbSNP
rs1047196083 2318 dbSNP
rs1218298647 2329 dbSNP
rs909937876 2329 dbSNP
rs1209932079 2334 dbSNP
rs769973358 2335 dbSNP
rs1415418240 2341 dbSNP
rs1339805766 2345 dbSNP
rs969437169 2346 dbSNP
rs532251014 2348 dbSNP
rs1397003922 2349 dbSNP
rs920049725 2354 dbSNP
rs1463794765 2356 dbSNP
rs185199119 2357 dbSNP
rs899786840 2363 dbSNP
rs1472155431 2370 dbSNP
rs1237436883 2374 dbSNP
rs998049380 2375 dbSNP
rs1186111108 2379 dbSNP
rs983411217 2392 dbSNP
rs1239243675 2403 dbSNP
rs1323413072 2404 dbSNP
rs1316315158 2411 dbSNP
rs189622801 2422 dbSNP
rs1228989817 2426 dbSNP
rs1355667434 2437 dbSNP
rs1282475161 2438 dbSNP
rs1444339812 2451 dbSNP
rs902839370 2460 dbSNP
rs1209861193 2467 dbSNP
rs1168698561 2493 dbSNP
rs1326107964 2499 dbSNP
rs1372753142 2500 dbSNP
rs1404374235 2501 dbSNP
rs374460558 2506 dbSNP
rs168463 2520 dbSNP
rs1040722308 2549 dbSNP
rs1381416893 2552 dbSNP
rs374020105 2562 dbSNP
rs372003023 2563 dbSNP
rs1255146666 2570 dbSNP
rs1222646528 2574 dbSNP
rs1167344999 2577 dbSNP
rs1451218860 2593 dbSNP
rs1392430463 2595 dbSNP
rs1225526643 2606 dbSNP
rs957109728 2610 dbSNP
rs1308357388 2613 dbSNP
rs1237718950 2621 dbSNP
rs1372978177 2628 dbSNP
rs568823285 2632 dbSNP
rs932351297 2644 dbSNP
rs1042900346 2652 dbSNP
rs1325209828 2658 dbSNP
rs982349338 2658 dbSNP
rs904324812 2667 dbSNP
rs951372296 2671 dbSNP
rs1438356843 2674 dbSNP
rs998799698 2677 dbSNP
rs547800593 2679 dbSNP
rs1397312729 2688 dbSNP
rs1192134643 2691 dbSNP
rs531571017 2692 dbSNP
rs1477854981 2695 dbSNP
rs183348529 2702 dbSNP
rs895722710 2717 dbSNP
rs1488630537 2719 dbSNP
rs1293113210 2728 dbSNP
rs1325613607 2729 dbSNP
rs1245111990 2737 dbSNP
rs1274658167 2738 dbSNP
rs772046522 2750 dbSNP
rs1332104751 2755 dbSNP
rs1218371248 2756 dbSNP
rs1212458914 2761 dbSNP
rs975685209 2764 dbSNP
rs567958761 2768 dbSNP
rs1400099193 2769 dbSNP
rs1185166986 2777 dbSNP
rs921082131 2779 dbSNP
rs1261532740 2785 dbSNP
rs762460040 2788 dbSNP
rs1024928700 2789 dbSNP
rs969502714 2795 dbSNP
rs981230339 2796 dbSNP
rs1177261738 2799 dbSNP
rs1027168770 2800 dbSNP
rs35528284 2804 dbSNP
rs982954611 2817 dbSNP
rs908825070 2825 dbSNP
rs1262655454 2834 dbSNP
rs1191584197 2835 dbSNP
rs1486620871 2838 dbSNP
rs1256450798 2840 dbSNP
rs965614168 2841 dbSNP
rs750822018 2859 dbSNP
rs892918883 2866 dbSNP
rs1274828260 2877 dbSNP
rs1218901665 2882 dbSNP
rs1415942011 2890 dbSNP
rs1316915335 2900 dbSNP
rs1012663114 2906 dbSNP
rs1461002417 2910 dbSNP
rs552036179 2922 dbSNP
rs920894751 2925 dbSNP
rs1381975335 2948 dbSNP
rs1024254123 2949 dbSNP
rs571015978 2950 dbSNP
rs1357827707 2951 dbSNP
rs1455323464 2961 dbSNP
rs778375098 2963 dbSNP
rs553776184 2994 dbSNP
rs1466391244 2995 dbSNP
rs538064719 2997 dbSNP
rs1476206814 3024 dbSNP
rs1361095209 3038 dbSNP
rs1415155629 3039 dbSNP
rs1256810645 3041 dbSNP
rs1035277155 3045 dbSNP
rs1479159750 3051 dbSNP
rs951567587 3053 dbSNP
rs1353107072 3065 dbSNP
rs550404639 3068 dbSNP
rs1232186476 3071 dbSNP
rs925705418 3076 dbSNP
rs983228112 3077 dbSNP
rs1316933679 3080 dbSNP
rs1016928116 3082 dbSNP
rs1234627358 3083 dbSNP
rs550756143 3088 dbSNP
rs147927292 3095 dbSNP
rs1260652292 3102 dbSNP
rs1377607827 3111 dbSNP
rs963147344 3111 dbSNP
rs752401823 3116 dbSNP
rs1447899298 3124 dbSNP
rs1399883792 3127 dbSNP
rs975503530 3130 dbSNP
rs1459616928 3132 dbSNP
rs1369164010 3136 dbSNP
rs1422042766 3138 dbSNP
rs141681853 3148 dbSNP
rs1179025846 3154 dbSNP
rs1255678454 3176 dbSNP
rs895776733 3178 dbSNP
rs1474974152 3198 dbSNP
rs1236004659 3216 dbSNP
rs1215219580 3232 dbSNP
rs933839959 3237 dbSNP
rs565615870 3241 dbSNP
rs1183134863 3244 dbSNP
rs1014086198 3263 dbSNP
rs1320450510 3265 dbSNP
rs1312052248 3272 dbSNP
rs986563939 3283 dbSNP
rs539572025 3285 dbSNP
rs934595017 3298 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000329271.3 | 3UTR | UUUCCUCUGGCUCUAUUUAUGUUACUUUUUGCGAUAAGAACACUUAACAUAAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA -0.748 0.02 -0.762 0.01 8 Click to see details
STAD -0.748 0.04 -0.886 0.01 6 Click to see details
LUSC 0.678 0.05 0.250 0.29 7 Click to see details
LIHC -0.361 0.1 -0.336 0.12 14 Click to see details
UCEC 0.362 0.17 0.333 0.19 9 Click to see details
HNSC 0.326 0.26 0.086 0.44 6 Click to see details
PAAD -0.55 0.31 -1.000 0.5 3 Click to see details
KIRC 0.104 0.4 0.214 0.31 8 Click to see details
THCA 0.048 0.44 0.029 0.46 14 Click to see details
KIRP 0.096 0.44 -0.200 0.37 5 Click to see details
KIRP 0.096 0.44 -0.200 0.37 5 Click to see details
KIRP 0.096 0.44 -0.200 0.37 5 Click to see details
KIRP 0.096 0.44 -0.200 0.37 5 Click to see details
KIRP 0.096 0.44 -0.200 0.37 5 Click to see details
KIRP 0.096 0.44 -0.200 0.37 5 Click to see details
KIRP 0.096 0.44 -0.200 0.37 5 Click to see details
62 hsa-miR-2116-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT080547 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 2
MIRT135054 ADSS adenylosuccinate synthase 2 4
MIRT147317 KPNA2 karyopherin subunit alpha 2 2 4
MIRT154323 CEBPB CCAAT/enhancer binding protein beta 2 2
MIRT326799 SYAP1 synapse associated protein 1 2 2
MIRT357963 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT384296 GOLT1B golgi transport 1B 2 2
MIRT442316 UBE2Q1 ubiquitin conjugating enzyme E2 Q1 2 2
MIRT443785 ST13 ST13, Hsp70 interacting protein 2 2
MIRT446868 NBPF3 NBPF member 3 2 2
MIRT447647 RAB3GAP1 RAB3 GTPase activating protein catalytic subunit 1 2 2
MIRT448470 SLC45A4 solute carrier family 45 member 4 2 2
MIRT449121 XRRA1 X-ray radiation resistance associated 1 2 2
MIRT450245 TRIM66 tripartite motif containing 66 2 2
MIRT450270 F2RL2 coagulation factor II thrombin receptor like 2 2 2
MIRT450688 RPN2 ribophorin II 2 2
MIRT481123 AZIN1 antizyme inhibitor 1 2 4
MIRT497207 CDH7 cadherin 7 2 4
MIRT502956 CCNT2 cyclin T2 2 2
MIRT509226 KIF14 kinesin family member 14 2 6
MIRT515395 ARHGAP21 Rho GTPase activating protein 21 2 4
MIRT525559 MTRNR2L7 MT-RNR2-like 7 2 6
MIRT525608 MTRNR2L3 MT-RNR2-like 3 2 4
MIRT533254 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT535782 MTRNR2L11 MT-RNR2-like 11 2 6
MIRT535803 MTRNR2L10 MT-RNR2-like 10 2 4
MIRT543211 TMEM117 transmembrane protein 117 2 2
MIRT552792 YAF2 YY1 associated factor 2 2 2
MIRT553947 STAMBP STAM binding protein 2 2
MIRT556217 MB21D2 Mab-21 domain containing 2 2 2
MIRT566351 POLDIP2 DNA polymerase delta interacting protein 2 2 2
MIRT568429 GDNF glial cell derived neurotrophic factor 2 2
MIRT568521 ANP32E acidic nuclear phosphoprotein 32 family member E 2 2
MIRT573359 PDE3A phosphodiesterase 3A 2 2
MIRT574653 LMAN2 lectin, mannose binding 2 2 2
MIRT608172 ERBB2 erb-b2 receptor tyrosine kinase 2 2 2
MIRT610692 FAM89A family with sequence similarity 89 member A 2 2
MIRT618459 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT622281 SH3TC2 SH3 domain and tetratricopeptide repeats 2 2 2
MIRT624615 B3GALT5 beta-1,3-galactosyltransferase 5 2 2
MIRT631041 TAS2R30 taste 2 receptor member 30 2 2
MIRT638335 RCAN1 regulator of calcineurin 1 2 2
MIRT641630 KIAA1244 ARFGEF family member 3 1 1
MIRT649117 SRD5A1 steroid 5 alpha-reductase 1 2 2
MIRT652246 TPI1 triosephosphate isomerase 1 2 2
MIRT659865 CAPRIN1 cell cycle associated protein 1 2 4
MIRT669219 CAND1 cullin associated and neddylation dissociated 1 2 2
MIRT682585 CPA4 carboxypeptidase A4 2 2
MIRT690129 EPHX2 epoxide hydrolase 2 2 2
MIRT699793 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT699991 RPS24 ribosomal protein S24 2 2
MIRT710376 LMBR1 limb development membrane protein 1 2 2
MIRT710412 YTHDC1 YTH domain containing 1 2 2
MIRT710574 TNPO1 transportin 1 2 2
MIRT712045 STYK1 serine/threonine/tyrosine kinase 1 2 2
MIRT713292 ADAMTS20 ADAM metallopeptidase with thrombospondin type 1 motif 20 2 2
MIRT718211 TNRC6C trinucleotide repeat containing 6C 2 2
MIRT718809 SLC25A33 solute carrier family 25 member 33 2 2
MIRT719341 VGLL4 vestigial like family member 4 2 2
MIRT720841 C1orf52 chromosome 1 open reading frame 52 2 2
MIRT724076 NCKAP1L NCK associated protein 1 like 2 2
MIRT724602 AP3B1 adaptor related protein complex 3 beta 1 subunit 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-2116 5-Fluorouracil approved 3385 Microarray CNE cells 22614822 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-2116 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-2116 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-2116-5p Doxorubicin 31703 NSC123127 approved resistant High Hepatocellular Carcinoma cell line (HepG2)
hsa-miR-2116-5p Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-2116-5p Gefitinib 123631 NSC715055 approved sensitive cell line (HCC827)
hsa-miR-2116-5p Gefitinib 123631 NSC715055 approved resistant cell line (PC9)
hsa-miR-2116-5p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-2116-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-2116-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-miR-2116-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2116-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM17)
hsa-miR-2116-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2116-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-2116-5p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (1500 ng/ml)
hsa-miR-2116-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-2116-5p Cisplatin 5460033 NSC119875 approved resistant cell line (OVSAHO)
hsa-miR-2116-5p Cisplatin 5460033 NSC119875 approved resistant cell line (TOV-112D)

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