miRTarBase - #MIRT366247


—
pre-miRNA Information
pre-miRNA hsa-mir-8066   
Genomic Coordinates chr4: 101240795 - 101240872
Description Homo sapiens miR-8066 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-8066
Sequence 48| CAAUGUGAUCUUUUGGAUGUA |68
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs931560390 4 dbSNP
rs1189907448 6 dbSNP
rs1347410735 8 dbSNP
rs1422871438 10 dbSNP
rs1281396192 14 dbSNP
rs1236502030 19 dbSNP
rs929291819 20 dbSNP
rs756482594 21 dbSNP
Putative Targets

Gene Information
Gene Symbol VMA21   
Synonyms MEAX, XMEA
Description VMA21, vacuolar ATPase assembly factor
Transcript NM_001017980   
Expression
Putative miRNA Targets on VMA21
3'UTR of VMA21
(miRNA target sites are highlighted)		 
>VMA21|NM_001017980|3'UTR
   1 AGTGAACATCACCTTTTTATAGCATTAAATTCATTTTTTAAAATGATAAATGCTGGAGGGGGCCATCTGATTTGAATAAA
  81 GTTGAAAGAACATGTTAAAGTCAGTCTTAAGGAGTCACGTTTGAGTATGTAAATTTTGATCTTTCTAATATGTTGGTTTG
 161 TATATTCAGTTTTAACTGTATGAATCTGATTTGCAAATGAGAATTTGGAAAAGTTAGTTACAAAGAAATATGTTAATTTA
 241 ATTAGACAATACTCTGGAAGGAATTTTATCTTCTTTCAACAAAACATGTTTTATAGTATTCTGACTTACGGTTGCTTTTG
 321 AGTTTTACTCATTTGGATATATTAAGATGCACACAGTGAAGCAAATTAAACTCCACTTTACGCTGGAATGCTTTCTTTAG
 401 CATGAAAATACCAGGTCCTTGGATTTGGGATTTTAATTTCCTATGGAAAGTTGCTTAAATTGTGGACACTGGAATTAATC
 481 TGAATGTCACTGAGGAATTTCACATGAAGTGTAATCCCTAGTCAATAAGAATTATCCATTACATTATTTTATGGGAAAAC
 561 TAGGCTAAATTACATCCATTCAGGTAAAAGGACCTTAGCTTACTGAAGGATCTAAAGAGCAAAGCAAAGATCTCACTACT
 641 CAAACACTCAGCCTGCTTCCTTCAAGTCCCCTTGCAGGCCAGCTTTGTGCTTTGCAGACCAACTTTTTAATGAGATACTT
 721 TGCTTCCTCATTCAACATTGAAGCTAGGCTTCAATTAAAAGGTTCGAGGAAGCTCCATTTAAAATTGTTTTTTTTACTAT
 801 TTTTTAAAATTGTAGTGTATATGATAGGAATTTGCATTTAAATATGTTCATTTTTGCATATGTTAGGAGTGGAAACAATC
 881 TGGAAAACATTTTTTTTTCATCCAAAAAGTATTCTCCTTGGGCATATCTGATGGAAAAAAACCTTGATTTTATTTTCGTA
 961 TCTTTAGTCTGTGTTCTTTCTAGTTATTTGGTACTAATTATGTGCAATCTAAAAACACTCCCACAAGTATTTGTTTTTTA
1041 ATTATAAAATCATAGTATATGTTCTTTGTAGAAAACTGGAAAAATACATATTCAAACAGGAAAAAAAATCAAAATTCCCC
1121 ATAATGTTGCCATCTAAAAATAACCTCTATTTTAGTTGATATCCCGTATTCATTTTTGAAAGCCATTCCTTAATGCTAGT
1201 TTGATACACACTAAAAGTTTAGCTTACAAGTTCAAATTCTGCCAGCTTTTCCTGACAGCTATTTGCATTTTTTTCAGATG
1281 AGTGATTATTGGCCATTTTCTTTTTCTTTTTCTTTATTTTATTTATTTATTTTTTTGAGACAGAGTTTTGCTCTGTTGCC
1361 CAGGCTGGAGTGCAGTGGTGCAATCTCGGCTCACTGCAACCTCTGCCTCCTGGGTTCAAGTGATTCTCCACCTCAGCCTC
1441 CCAAGTAGCTGGGACTACGGATGCCTGCCACCACGCCTGGCTAATTTTTTTTTGTATTTTTTTGTAGAGACGGGGTTTCA
1521 CCATGTTGTCCAGGCTAATCTTGAACTTGTGACCTCAGGTGATCCACCCGCCTCGGCCTCCGAAAGTGCTGGGATTACAG
1601 GCGTGAGCTACCACGCCCGGCCTTATTGACCATTTTCTAAATAAGCACATTCTATCTTTATTCTCTTAAAATTCAAATTT
1681 TCTGTTACTGATAATCCTAATACTAGGATTCTTGCTTAAGTATGTGAAACCATTACCGATTTGTTGTTCACATTTATTTT
1761 TTATGTTGTGAAACTGGACTAAAGGAATAGAGGGATGATTAGTCATAAAAGTCAAATAGCATTTGTGTTTAACTGTTGAG
1841 AAAAGTGAAAGATCAGTATGATTATTATGGAACTGTTTTTAATTCTTGCTTAAAGACTACAATTTTAGTATAATGACATT
1921 TGAGTCTAGGGTAGTATGTGGTAGATTTCTAGATGGTCCCTAATTAAGAAGTATTGTTGTATTTAGAATTGTCCACCTAA
2001 TTTCTTTTTATATAATGCCAAGGTATTTCTTGTGCTTTTGGGATCTTATGCTGTTTGTAAAATGTTACTGTCCAATGTTG
2081 GATTATTGTTTTGGTTTCAGGCATTTGCTGAATAGGTGATGATACATGGGTATTTTTCTGCAAGTATTTAAACCAGGGGC
2161 ATATGCAAAGGCAGTTGTAATTTCCTCTTGGAAAAAGCGCCAAATGTTTGAAGGTTAAAATCAAATGCTAGGGTTGATAT
2241 TTAGGCTTATAACAAAATAGGCTTGTTTTCAAAGCAGTTTTTTCCTAGAGTTTTAACTGTTAACTCACTAGTTTGCTGCT
2321 GTTTTTAACTATGTTAAATAACATATGGTATTTGGCAAATAGATTTATTTTTCAAAATGTCTCACTAGTTTCCTTTTACA
2401 CAATGTATATACTTCAAGATGTATAGAAAGGAAAGCTACAGTTGAGCCCTTATACATGTTTTAAGGTAGAAATATGTTCC
2481 CTATTGTTTGAAAACTGATTGTAAGAATAACCTCAGTTAGGAGATATAACTTGAAGTGTCAGTCCAAACTACTGATTTAA
2561 CCCTATTTACGGTAACACATTACCTTCCTCACCTCCTGTTTGGCCCTGGAGAATGTAGTCCTTTTTCTCATTTGTGTTGA
2641 GAAATGAAAAGTCTGCTGTAGAATGTATCTGATGTCATTAGTTCTTCAAATGGATACCATTGTACATATAACAGTAGAAT
2721 TTGGTTTGGGGTTGTTAGTGAAAAAAAATTTAAACCTGCCATTAAAAATCCCCATGTTTCATGGAAATCTAACAGAAATA
2801 CATTGTAATAATTAGAACATTTTGTTTTCTTTTTTCTTTTTTTTTTTTTCGAGACGGAGTTTTGCCCTTCTTGCCCAGGC
2881 TGGAGTGCAAGGGCGCAATCTCGGCTCGCTGCAACCTCCGCCTCCCGGGTTCAAGCAGTTCTCCTGCCTCAGCCCCCTGA
2961 GTACCTCAGATGACAGGTGCGTGCCACCACACCCGGCTAATTTTTGTATTTTTAGTAGAGACGGGGTTTCACCATGTTAG
3041 CCAGGCTAGTCTCGAACTCCTGACCTCAGGTGATCCACCCGCCTCCGCCTCCCAAAGTGCTGGGATTACAGGTATCAGCC
3121 ACCGTGCCTGGCCTAATAATTGGAACATTTTCATCATGAAAATGTCATCAGCTTTGCCAAAAGAAACAACCAATTGACTT
3201 GTTTGGCGTTTGTTTTCCATTTTCATGTCAATTTTATGTATACAGTTAGAATACCCAAGGAGACCACTAAAATCAGTTAA
3281 ACAAGTAGGGTATATACAAAGAAAGATGAAACCCGAAAGTACATAAAAAGGATTTAAATCCGATTTTAGATGTACCTAGT
3361 GTGTATTTCTTATCTCTAGACAAGTTCATGTTTATTGTTTAATTTATGCCCAAGTGAAGTTGTAAACTTATGGTTCAACT
3441 CTGACACAGAATTTGTCACTTGTCTGAGGTCAGTGGCAGGTTTCTCTGCTGTCAAGCACTCTGTGTCACCCACCAGATTA
3521 GTATAACTATTAATTCAGACTGTACTCCTATGTTTAAGATAATTTTTACAAGAGCTGGCTGAAGCAGCACATTAGTAACC
3601 TGACAAGATTTCTTTTTCCCTTTTCAGGGGGAAAGGGTCACCTTAAAAATAAATTATTTTCAGGGACTTTGGGAATCTAA
3681 TGATAAATATTACACATAATCTATGAATAGCTTAATCCTTTATATATTCCTTAAAATAGGAATTCCTCGACATCACTCCT
3761 GGCCACACTTTCCTTGCCTGTGTTGTTGCTATGTGTATTTGAAAGTAATATCTGCATTCCTTTTAAGATGTTCTGTAAGT
3841 CATATTTGTCAGTTATACAGAGTAGTCTTCCTTTTCCCCACGTTCAGTGTAATCTCACTGAACAGTAATAATAGCAATAG
3921 CTAACAACATCTGCACAGCACCTTACAGTTTGCAAAGAACGTTCACACATTCTCATTTGAGTTTTGCATAGTGAACCTGT
4001 TACGAGATGTCTCTTGACGTCGATGCTAAAAGTGTTAGAATCTTTACATCACTAGAGTCATTGAATATGCTGTAGTATTG
4081 AATAGTGCCCTGACTAGGGGGAGGATTTGGATGTGCTGCATTTCAAGCCGTGTATAATCATCAAAATGGGGGGCTTGAGT
4161 TCTTTAGCTACTTGAATCCGATTTACTTCTGTTAAGTGATGCTTTTCTAACCGTTTTCTGGATGGATTTTGTATTCACTA
4241 TATTGTAGCTTGTAATTTGTATAAATGTACCATCTGATGTCATTAAAAAAAGTGTTTGTAGTGCTAAAAAAAAAAAAAAA
4321 AAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' auGU-AGGUUUUCU-AGUGUAAc 5'
            || ||: ||:|| ||||:|| 
Target 5' gtCAGTCTTAAGGAGTCACGTTt 3'
 100 - 122 147.00 -11.40
2 
miRNA  3' auGUA--GGUU----UUCUAGUGUAAc 5'
            |||  ||:|      | ||||||| 
Target 5' acCATTACCGATTTGTTGTTCACATTt 3'
 1729 - 1755 143.00 -8.70
3 
miRNA  3' auguAGGUUUUCUAGUGUAAc 5'
              ||:: ||| |||:||| 
Target 5' atgtTCTGTAAG-TCATATTt 3'
 3828 - 3847 140.00 -6.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
208803 7 ClinVar
208805 13 ClinVar
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs763492918 7 dbSNP
rs878854355 7 dbSNP
rs372822114 10 dbSNP
rs1286593356 15 dbSNP
rs1050236372 18 dbSNP
rs1327698159 34 dbSNP
rs376244455 45 dbSNP
rs759636959 47 dbSNP
rs765271039 51 dbSNP
rs889868106 63 dbSNP
rs764940224 64 dbSNP
rs191937091 77 dbSNP
rs1033120961 81 dbSNP
rs1050124032 99 dbSNP
rs762469521 109 dbSNP
rs372929263 119 dbSNP
rs1454245279 120 dbSNP
rs956305438 125 dbSNP
rs1350066731 138 dbSNP
rs146494103 142 dbSNP
rs1452520006 177 dbSNP
rs1294891756 179 dbSNP
rs1354080011 184 dbSNP
rs1261370425 190 dbSNP
rs1203626282 194 dbSNP
rs1353031104 195 dbSNP
rs1227540261 201 dbSNP
rs1286866463 204 dbSNP
rs866977691 211 dbSNP
rs150170190 212 dbSNP
rs138037107 214 dbSNP
rs368403239 214 dbSNP
rs57412333 214 dbSNP
rs202068639 216 dbSNP
rs866356920 218 dbSNP
rs867134079 219 dbSNP
rs1345699586 220 dbSNP
rs1305492705 223 dbSNP
rs1309209736 233 dbSNP
rs1325631863 244 dbSNP
rs1315895440 246 dbSNP
rs947033573 250 dbSNP
rs1023930457 269 dbSNP
rs1041751355 269 dbSNP
rs971436785 271 dbSNP
rs1393849629 272 dbSNP
rs1174823231 286 dbSNP
rs1478609623 288 dbSNP
rs979784918 289 dbSNP
rs1191432356 296 dbSNP
rs756439092 308 dbSNP
rs1189708515 310 dbSNP
rs927076188 311 dbSNP
rs951812169 316 dbSNP
rs1282452679 320 dbSNP
rs780269282 322 dbSNP
rs1219757686 324 dbSNP
rs1057050701 330 dbSNP
rs1268234317 333 dbSNP
rs754294894 334 dbSNP
rs1340798938 338 dbSNP
rs1311867776 341 dbSNP
rs755218792 353 dbSNP
rs376895229 355 dbSNP
rs907680208 382 dbSNP
rs1012785075 384 dbSNP
rs1376758416 386 dbSNP
rs771622462 395 dbSNP
rs975957830 403 dbSNP
rs777113887 412 dbSNP
rs1396340930 424 dbSNP
rs1006319786 444 dbSNP
rs779324775 451 dbSNP
rs934016743 458 dbSNP
rs769307681 462 dbSNP
rs1049746441 529 dbSNP
rs1420792599 539 dbSNP
rs889890157 542 dbSNP
rs1187473718 552 dbSNP
rs1432209609 561 dbSNP
rs1015307635 568 dbSNP
rs748191957 579 dbSNP
rs1210862250 584 dbSNP
rs1437191670 609 dbSNP
rs936059985 618 dbSNP
rs1054571896 625 dbSNP
rs141031699 636 dbSNP
rs976735529 639 dbSNP
rs1010454944 640 dbSNP
rs1292359516 641 dbSNP
rs1231080732 642 dbSNP
rs923579035 647 dbSNP
rs759856152 651 dbSNP
rs1440804790 654 dbSNP
rs1354507980 666 dbSNP
rs1314931324 671 dbSNP
rs907450209 672 dbSNP
rs986284351 676 dbSNP
rs1446961183 683 dbSNP
rs914759312 686 dbSNP
rs1164582308 688 dbSNP
rs1270583632 705 dbSNP
rs183611158 708 dbSNP
rs1416171434 712 dbSNP
rs1182571709 724 dbSNP
rs1469665654 724 dbSNP
rs1363953521 736 dbSNP
rs1231173194 739 dbSNP
rs1226156145 752 dbSNP
rs1180417790 753 dbSNP
rs1458114026 756 dbSNP
rs1272352537 763 dbSNP
rs1001633132 766 dbSNP
rs1323191177 767 dbSNP
rs947108575 767 dbSNP
rs1290104921 775 dbSNP
rs777786751 776 dbSNP
rs1370517905 782 dbSNP
rs1041474909 784 dbSNP
rs1449662023 787 dbSNP
rs746934286 788 dbSNP
rs762365631 801 dbSNP
rs1276006295 811 dbSNP
rs1034008046 822 dbSNP
rs1441518601 827 dbSNP
rs1400254777 859 dbSNP
rs951787218 862 dbSNP
rs3207598 870 dbSNP
rs1243101313 884 dbSNP
rs188503869 886 dbSNP
rs1057415872 890 dbSNP
rs1252270802 890 dbSNP
rs1440263162 890 dbSNP
rs961839257 894 dbSNP
rs575770171 895 dbSNP
rs975903811 905 dbSNP
rs1246981458 918 dbSNP
rs1214646046 923 dbSNP
rs923218799 926 dbSNP
rs1314690916 937 dbSNP
rs5970036 959 dbSNP
rs769416762 963 dbSNP
rs1355110115 969 dbSNP
rs985891828 981 dbSNP
rs911203664 992 dbSNP
rs1398318951 994 dbSNP
rs1385521009 997 dbSNP
rs1370168512 1005 dbSNP
rs762677432 1023 dbSNP
rs1430284703 1026 dbSNP
rs1343605175 1028 dbSNP
rs1400287015 1031 dbSNP
rs888290401 1043 dbSNP
rs936092470 1045 dbSNP
rs1394473016 1056 dbSNP
rs1006680888 1069 dbSNP
rs1015052002 1071 dbSNP
rs1326202761 1079 dbSNP
rs1054437339 1085 dbSNP
rs891873643 1090 dbSNP
rs1484704694 1092 dbSNP
rs1264856742 1100 dbSNP
rs1216758712 1101 dbSNP
rs962342402 1119 dbSNP
rs1280315019 1122 dbSNP
rs997553465 1144 dbSNP
rs1432638072 1150 dbSNP
rs1302437251 1154 dbSNP
rs1214327956 1166 dbSNP
rs1030520364 1167 dbSNP
rs1371668191 1169 dbSNP
rs763523869 1172 dbSNP
rs1311068400 1186 dbSNP
rs1467548415 1189 dbSNP
rs1359626756 1199 dbSNP
rs1169548104 1207 dbSNP
rs1426488773 1209 dbSNP
rs1045884120 1214 dbSNP
rs907478638 1218 dbSNP
rs1001763505 1230 dbSNP
rs1193917968 1243 dbSNP
rs1474644515 1254 dbSNP
rs775152306 1256 dbSNP
rs1254781471 1262 dbSNP
rs751132488 1266 dbSNP
rs1201631858 1268 dbSNP
rs1484553809 1271 dbSNP
rs193229751 1283 dbSNP
rs1272612407 1291 dbSNP
rs1316430412 1296 dbSNP
rs573627542 1296 dbSNP
rs953605542 1296 dbSNP
rs1310696093 1306 dbSNP
rs1397841494 1306 dbSNP
rs866175886 1311 dbSNP
rs1205414801 1313 dbSNP
rs761720610 1322 dbSNP
rs1402214322 1326 dbSNP
rs1171042389 1331 dbSNP
rs1005982342 1341 dbSNP
rs1415181045 1342 dbSNP
rs1460626096 1342 dbSNP
rs1285387779 1343 dbSNP
rs1423882662 1346 dbSNP
rs1257554045 1353 dbSNP
rs986357881 1357 dbSNP
rs1014713583 1362 dbSNP
rs185633245 1368 dbSNP
rs914708389 1379 dbSNP
rs1469330491 1382 dbSNP
rs1201057288 1389 dbSNP
rs374436208 1390 dbSNP
rs976342363 1400 dbSNP
rs1376046931 1406 dbSNP
rs1306312011 1427 dbSNP
rs1444483697 1439 dbSNP
rs1378972489 1454 dbSNP
rs968916477 1459 dbSNP
rs189302172 1460 dbSNP
rs1388215874 1471 dbSNP
rs977572169 1472 dbSNP
rs191301448 1475 dbSNP
rs924414070 1476 dbSNP
rs1156257225 1477 dbSNP
rs75469696 1484 dbSNP
rs35275320 1485 dbSNP
rs78504946 1486 dbSNP
rs1240551254 1487 dbSNP
rs1179705468 1491 dbSNP
rs1159434792 1494 dbSNP
rs992484700 1497 dbSNP
rs1265607971 1507 dbSNP
rs1211874898 1519 dbSNP
rs1488892621 1528 dbSNP
rs953437968 1539 dbSNP
rs1260250534 1551 dbSNP
rs1018033033 1553 dbSNP
rs1455397984 1555 dbSNP
rs1319675935 1564 dbSNP
rs966129070 1567 dbSNP
rs948586356 1568 dbSNP
rs767486519 1570 dbSNP
rs911223086 1571 dbSNP
rs957404722 1573 dbSNP
rs761081873 1576 dbSNP
rs1383728796 1580 dbSNP
rs913343278 1581 dbSNP
rs1330069921 1582 dbSNP
rs1239146860 1583 dbSNP
rs1159772560 1591 dbSNP
rs946123376 1599 dbSNP
rs939906539 1603 dbSNP
rs755819285 1604 dbSNP
rs928794571 1615 dbSNP
rs937591685 1620 dbSNP
rs1036839651 1627 dbSNP
rs1286754980 1633 dbSNP
rs766949517 1634 dbSNP
rs1210081030 1639 dbSNP
rs754127957 1646 dbSNP
rs1056016120 1666 dbSNP
rs1276417010 1677 dbSNP
rs183801280 1688 dbSNP
rs1325533947 1689 dbSNP
rs1005927682 1690 dbSNP
rs1275912051 1692 dbSNP
rs1401376137 1706 dbSNP
rs1030258944 1708 dbSNP
rs188510420 1709 dbSNP
rs1414430804 1732 dbSNP
rs752973487 1734 dbSNP
rs1174730037 1739 dbSNP
rs1007726810 1753 dbSNP
rs1451047746 1753 dbSNP
rs758494839 1783 dbSNP
rs1423251744 1784 dbSNP
rs1191793830 1799 dbSNP
rs1478886568 1803 dbSNP
rs1264031505 1814 dbSNP
rs1186865029 1818 dbSNP
rs555926860 1830 dbSNP
rs1280607419 1835 dbSNP
rs1182645179 1836 dbSNP
rs1200893779 1837 dbSNP
rs1338492520 1846 dbSNP
rs1254193203 1854 dbSNP
rs997244736 1855 dbSNP
rs7067140 1856 dbSNP
rs1292159065 1861 dbSNP
rs150205644 1863 dbSNP
rs1007799465 1865 dbSNP
rs757113678 1874 dbSNP
rs1339268505 1876 dbSNP
rs1336702487 1894 dbSNP
rs181310196 1900 dbSNP
rs745608094 1901 dbSNP
rs1400032016 1902 dbSNP
rs1032262193 1905 dbSNP
rs1168931222 1909 dbSNP
rs1021871508 1911 dbSNP
rs752797988 1923 dbSNP
rs1459375869 1929 dbSNP
rs758714812 1937 dbSNP
rs7066731 1961 dbSNP
rs1471850513 1968 dbSNP
rs969279205 1971 dbSNP
rs1389943254 1975 dbSNP
rs1391417031 1980 dbSNP
rs1188185043 1990 dbSNP
rs1457215864 1992 dbSNP
rs957930585 2000 dbSNP
rs1200250025 2005 dbSNP
rs990138820 2019 dbSNP
rs1309354307 2022 dbSNP
rs1272114871 2031 dbSNP
rs1226175147 2033 dbSNP
rs879173012 2044 dbSNP
rs1357862573 2050 dbSNP
rs35860657 2069 dbSNP
rs747133359 2071 dbSNP
rs775062279 2072 dbSNP
rs1449439423 2074 dbSNP
rs1376745254 2100 dbSNP
rs1032275685 2111 dbSNP
rs771534207 2115 dbSNP
rs1408896798 2119 dbSNP
rs1401380335 2120 dbSNP
rs1288103260 2126 dbSNP
rs1403761294 2126 dbSNP
rs186883339 2127 dbSNP
rs1336007876 2129 dbSNP
rs1163876285 2131 dbSNP
rs981509204 2138 dbSNP
rs1439034461 2143 dbSNP
rs1378380266 2159 dbSNP
rs1180322199 2160 dbSNP
rs1458044661 2166 dbSNP
rs1245854868 2169 dbSNP
rs1218930288 2194 dbSNP
rs1247453381 2195 dbSNP
rs879103893 2200 dbSNP
rs1289996619 2203 dbSNP
rs190080635 2224 dbSNP
rs1264149927 2236 dbSNP
rs992587020 2246 dbSNP
rs1242845012 2262 dbSNP
rs1378131490 2266 dbSNP
rs937558537 2267 dbSNP
rs915542435 2271 dbSNP
rs1351785069 2272 dbSNP
rs1356294188 2278 dbSNP
rs948408610 2284 dbSNP
rs1056363407 2286 dbSNP
rs984032500 2289 dbSNP
rs1160398002 2297 dbSNP
rs1276917014 2317 dbSNP
rs1482189238 2318 dbSNP
rs909827377 2323 dbSNP
rs939829935 2331 dbSNP
rs773702878 2332 dbSNP
rs781749750 2339 dbSNP
rs1189193533 2344 dbSNP
rs1478832096 2347 dbSNP
rs182244739 2357 dbSNP
rs1246891474 2359 dbSNP
rs1215340618 2364 dbSNP
rs1487013121 2365 dbSNP
rs1036841577 2366 dbSNP
rs942244203 2385 dbSNP
rs1318009379 2389 dbSNP
rs1301047073 2391 dbSNP
rs1258491262 2404 dbSNP
rs1284160163 2408 dbSNP
rs1036040931 2410 dbSNP
rs746408014 2411 dbSNP
rs1358704814 2412 dbSNP
rs553621770 2413 dbSNP
rs1300070632 2416 dbSNP
rs1420254210 2426 dbSNP
rs1358481889 2435 dbSNP
rs571920704 2436 dbSNP
rs41302170 2445 dbSNP
rs187212963 2447 dbSNP
rs189661830 2454 dbSNP
rs1007549104 2465 dbSNP
rs759914713 2473 dbSNP
rs1264746951 2480 dbSNP
rs1021813849 2481 dbSNP
rs888862342 2484 dbSNP
rs904750895 2485 dbSNP
rs1169918878 2487 dbSNP
rs1368233252 2488 dbSNP
rs1314297975 2489 dbSNP
rs999526979 2511 dbSNP
rs1218283912 2514 dbSNP
rs1338645527 2525 dbSNP
rs1280231460 2526 dbSNP
rs1007416588 2528 dbSNP
rs774616491 2543 dbSNP
rs180869527 2550 dbSNP
rs960488768 2555 dbSNP
rs768349490 2560 dbSNP
rs1020243960 2571 dbSNP
rs967369443 2572 dbSNP
rs1169649864 2576 dbSNP
rs1463759011 2578 dbSNP
rs1425302871 2591 dbSNP
rs1170821608 2597 dbSNP
rs1422725489 2601 dbSNP
rs992577211 2619 dbSNP
rs176454 2620 dbSNP
rs1035817999 2625 dbSNP
rs374374491 2630 dbSNP
rs1244154083 2634 dbSNP
rs969701807 2642 dbSNP
rs983810117 2663 dbSNP
rs1398111012 2674 dbSNP
rs753169819 2678 dbSNP
rs1321207985 2683 dbSNP
rs1487172002 2687 dbSNP
rs532620326 2710 dbSNP
rs866900373 2716 dbSNP
rs945526370 2741 dbSNP
rs979620978 2752 dbSNP
rs368001505 2755 dbSNP
rs773822714 2758 dbSNP
rs973067505 2759 dbSNP
rs909350285 2760 dbSNP
rs922419990 2764 dbSNP
rs372015243 2774 dbSNP
rs1298381542 2788 dbSNP
rs1457047932 2802 dbSNP
rs1276857589 2814 dbSNP
rs12854949 2826 dbSNP
rs1366234250 2827 dbSNP
rs942276882 2829 dbSNP
rs972276569 2832 dbSNP
rs1426124974 2837 dbSNP
rs755370141 2837 dbSNP
rs764420276 2837 dbSNP
rs1051788641 2844 dbSNP
rs1240347381 2850 dbSNP
rs919501742 2850 dbSNP
rs1196604245 2851 dbSNP
rs1204537790 2852 dbSNP
rs185462390 2856 dbSNP
rs910659803 2857 dbSNP
rs767040602 2861 dbSNP
rs943475319 2863 dbSNP
rs1378857629 2865 dbSNP
rs1198484628 2871 dbSNP
rs1255273798 2875 dbSNP
rs1307360647 2878 dbSNP
rs1429040486 2886 dbSNP
rs757382856 2895 dbSNP
rs1051848317 2896 dbSNP
rs1366793214 2903 dbSNP
rs888902590 2903 dbSNP
rs943086769 2904 dbSNP
rs1053570211 2908 dbSNP
rs780923323 2909 dbSNP
rs1382584567 2920 dbSNP
rs1182925584 2925 dbSNP
rs1432873759 2926 dbSNP
rs1265500476 2927 dbSNP
rs1009445930 2928 dbSNP
rs1490530598 2942 dbSNP
rs1285327704 2952 dbSNP
rs1214368742 2955 dbSNP
rs1020860619 2975 dbSNP
rs1355703409 2980 dbSNP
rs772966608 2981 dbSNP
rs1002899245 2982 dbSNP
rs1036086715 2983 dbSNP
rs1464270951 2996 dbSNP
rs999076221 3000 dbSNP
rs745816220 3015 dbSNP
rs1301443568 3023 dbSNP
rs1402027296 3024 dbSNP
rs1418435542 3032 dbSNP
rs1436283303 3043 dbSNP
rs958829948 3049 dbSNP
rs991546841 3054 dbSNP
rs190173953 3055 dbSNP
rs1227710505 3060 dbSNP
rs963574301 3081 dbSNP
rs760666467 3082 dbSNP
rs183110557 3087 dbSNP
rs1231418152 3088 dbSNP
rs749121841 3094 dbSNP
rs919541033 3098 dbSNP
rs895975885 3110 dbSNP
rs1199716052 3121 dbSNP
rs529860314 3124 dbSNP
rs768170950 3125 dbSNP
rs1223779596 3158 dbSNP
rs1316863462 3162 dbSNP
rs1275813554 3166 dbSNP
rs1401273755 3173 dbSNP
rs910187927 3191 dbSNP
rs1022706416 3207 dbSNP
rs943126958 3209 dbSNP
rs1005321463 3213 dbSNP
rs367577819 3224 dbSNP
rs747569974 3227 dbSNP
rs893546987 3237 dbSNP
rs1423140889 3246 dbSNP
rs1470452356 3246 dbSNP
rs1464416591 3255 dbSNP
rs972674004 3267 dbSNP
rs922545389 3277 dbSNP
rs1186754481 3281 dbSNP
rs1440587012 3291 dbSNP
rs1244768097 3293 dbSNP
rs1204037811 3295 dbSNP
rs1193684791 3296 dbSNP
rs771617864 3315 dbSNP
rs1219999221 3316 dbSNP
rs1431089804 3320 dbSNP
rs1042182674 3321 dbSNP
rs955195491 3326 dbSNP
rs985236210 3341 dbSNP
rs911067167 3342 dbSNP
rs1174836664 3343 dbSNP
rs1339179426 3351 dbSNP
rs188543019 3354 dbSNP
rs6627161 3357 dbSNP
rs760108765 3365 dbSNP
rs766085926 3380 dbSNP
rs112595787 3393 dbSNP
rs925972320 3395 dbSNP
rs1329573288 3403 dbSNP
rs1411801880 3418 dbSNP
rs1035712699 3422 dbSNP
rs934689523 3432 dbSNP
rs1053358656 3438 dbSNP
rs1386982357 3446 dbSNP
rs896091269 3455 dbSNP
rs191626805 3460 dbSNP
rs1438009566 3466 dbSNP
rs1044556988 3467 dbSNP
rs1294180614 3471 dbSNP
rs938259568 3482 dbSNP
rs1369909446 3490 dbSNP
rs41314149 3510 dbSNP
rs1317758187 3518 dbSNP
rs1300782578 3522 dbSNP
rs1247273119 3525 dbSNP
rs1376632733 3546 dbSNP
rs6627162 3549 dbSNP
rs147083260 3551 dbSNP
rs11555859 3560 dbSNP
rs1229963514 3570 dbSNP
rs1444665076 3571 dbSNP
rs183880461 3573 dbSNP
rs1323020142 3580 dbSNP
rs1005267723 3581 dbSNP
rs1266064058 3583 dbSNP
rs1017135984 3589 dbSNP
rs1438940689 3592 dbSNP
rs187756671 3596 dbSNP
rs1378292106 3606 dbSNP
rs761738015 3620 dbSNP
rs961065078 3624 dbSNP
rs767618049 3627 dbSNP
rs1026872938 3630 dbSNP
rs751861525 3631 dbSNP
rs1218811482 3636 dbSNP
rs1490700157 3641 dbSNP
rs757363161 3646 dbSNP
rs1248387476 3649 dbSNP
rs1223923963 3650 dbSNP
rs138457145 3658 dbSNP
rs1282654756 3666 dbSNP
rs988090893 3676 dbSNP
rs1190146556 3696 dbSNP
rs910226108 3699 dbSNP
rs1029349056 3721 dbSNP
rs964378269 3730 dbSNP
rs985350664 3735 dbSNP
rs1347473411 3736 dbSNP
rs1303799282 3737 dbSNP
rs1161800348 3749 dbSNP
rs1410288843 3750 dbSNP
rs989101489 3764 dbSNP
rs1018022017 3767 dbSNP
rs915012919 3768 dbSNP
rs781342453 3777 dbSNP
rs1424130495 3784 dbSNP
rs1189099583 3799 dbSNP
rs978859353 3828 dbSNP
rs926056720 3831 dbSNP
rs756014647 3839 dbSNP
rs746290338 3843 dbSNP
rs1293054747 3844 dbSNP
rs1351313860 3855 dbSNP
rs989196966 3857 dbSNP
rs1411965691 3867 dbSNP
rs1488272550 3870 dbSNP
rs917269636 3878 dbSNP
rs780014544 3883 dbSNP
rs1042236619 3886 dbSNP
rs1317913086 3887 dbSNP
rs927762663 3888 dbSNP
rs1044672435 3892 dbSNP
rs1325873301 3895 dbSNP
rs753579026 3901 dbSNP
rs1284060529 3912 dbSNP
rs1399448154 3918 dbSNP
rs754831698 3961 dbSNP
rs1290572487 3974 dbSNP
rs1431296294 3976 dbSNP
rs1358391153 3984 dbSNP
rs1173634981 3985 dbSNP
rs1291874091 3989 dbSNP
rs906028457 3991 dbSNP
rs1319887484 4004 dbSNP
rs941560507 4005 dbSNP
rs1188806081 4014 dbSNP
rs1220148413 4015 dbSNP
rs1055486723 4019 dbSNP
rs756709051 4020 dbSNP
rs144010777 4023 dbSNP
rs1048391 4026 dbSNP
rs1462858090 4029 dbSNP
rs1048393 4031 dbSNP
rs1048396 4033 dbSNP
rs1048398 4035 dbSNP
rs1048400 4040 dbSNP
rs896142962 4044 dbSNP
rs1182830770 4061 dbSNP
rs1305838066 4070 dbSNP
rs1297759641 4083 dbSNP
rs1215110081 4087 dbSNP
rs1378318857 4097 dbSNP
rs1029707985 4101 dbSNP
rs1012946462 4118 dbSNP
rs1406439929 4129 dbSNP
rs371661173 4130 dbSNP
rs1006758501 4131 dbSNP
rs1018180432 4138 dbSNP
rs899264112 4154 dbSNP
rs192677771 4158 dbSNP
rs993559936 4161 dbSNP
rs1429683757 4165 dbSNP
rs979696803 4166 dbSNP
rs147315626 4180 dbSNP
rs956293081 4181 dbSNP
rs988921891 4190 dbSNP
rs1198281556 4191 dbSNP
rs1306346220 4193 dbSNP
rs917217738 4207 dbSNP
rs780265419 4213 dbSNP
rs1009058228 4214 dbSNP
rs1312813176 4215 dbSNP
rs1248009671 4241 dbSNP
rs1383266887 4250 dbSNP
rs749869522 4255 dbSNP
rs1398489753 4270 dbSNP
rs927560080 4283 dbSNP
rs1298296891 4285 dbSNP
rs1448429631 4286 dbSNP
rs1285772068 4293 dbSNP
rs765918705 4293 dbSNP
rs941519460 4302 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000330374.6 | 3UTR | UAACACAUUACCUUCCUCACCUCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
92 hsa-miR-8066 Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT060588 CCND1 cyclin D1 2 2
MIRT067440 RIMKLB ribosomal modification protein rimK like family member B 2 2
MIRT078862 WBP2 WW domain binding protein 2 2 2
MIRT088062 UBXN2A UBX domain protein 2A 2 4
MIRT088214 NUP50 nucleoporin 50 2 2
MIRT103494 HOXA3 homeobox A3 2 8
MIRT135196 TMBIM6 transmembrane BAX inhibitor motif containing 6 2 4
MIRT177727 REEP3 receptor accessory protein 3 2 2
MIRT179439 TBRG1 transforming growth factor beta regulator 1 2 4
MIRT191647 SLC39A9 solute carrier family 39 member 9 2 2
MIRT192342 KLF13 Kruppel like factor 13 2 2
MIRT212035 RAPGEF2 Rap guanine nucleotide exchange factor 2 2 2
MIRT215387 CREBRF CREB3 regulatory factor 2 2
MIRT235001 IER2 immediate early response 2 2 2
MIRT238793 TPD52L1 tumor protein D52 like 1 2 2
MIRT273384 SMARCD1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 1 2 4
MIRT280473 UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2 2
MIRT298320 SLC5A3 solute carrier family 5 member 3 2 2
MIRT309180 SPATA5 spermatogenesis associated 5 2 2
MIRT354483 LRRC58 leucine rich repeat containing 58 2 2
MIRT354710 SLC25A36 solute carrier family 25 member 36 2 2
MIRT361004 CDC5L cell division cycle 5 like 2 4
MIRT366247 VMA21 VMA21, vacuolar ATPase assembly factor 2 2
MIRT405774 EIF5 eukaryotic translation initiation factor 5 2 2
MIRT442640 TBC1D12 TBC1 domain family member 12 2 2
MIRT443928 ZNF99 zinc finger protein 99 2 2
MIRT454287 FXN frataxin 2 2
MIRT454367 ASAH2 N-acylsphingosine amidohydrolase 2 2 2
MIRT463574 ZBTB39 zinc finger and BTB domain containing 39 2 6
MIRT464484 UGCG UDP-glucose ceramide glucosyltransferase 2 2
MIRT466866 STX6 syntaxin 6 2 2
MIRT467283 SPNS1 sphingolipid transporter 1 (putative) 2 2
MIRT470298 PPTC7 PTC7 protein phosphatase homolog 2 2
MIRT471630 PAPD7 poly(A) RNA polymerase D7, non-canonical 2 2
MIRT472802 MTMR4 myotubularin related protein 4 2 4
MIRT474708 KIF3A kinesin family member 3A 2 2
MIRT478256 DDX3X DEAD-box helicase 3, X-linked 2 2
MIRT479330 CERS2 ceramide synthase 2 2 2
MIRT480658 BSCL2 BSCL2, seipin lipid droplet biogenesis associated 2 2
MIRT481954 ANKRD11 ankyrin repeat domain 11 2 2
MIRT482895 IAH1 isoamyl acetate-hydrolyzing esterase 1 homolog 2 4
MIRT493634 HIC2 HIC ZBTB transcriptional repressor 2 2 2
MIRT500847 SYPL1 synaptophysin like 1 2 4
MIRT502035 LRIG2 leucine rich repeats and immunoglobulin like domains 2 2 2
MIRT502185 IGSF3 immunoglobulin superfamily member 3 2 4
MIRT502605 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 2 10
MIRT502977 CCNL1 cyclin L1 2 8
MIRT504725 PLEKHA6 pleckstrin homology domain containing A6 2 10
MIRT504778 CLEC2D C-type lectin domain family 2 member D 2 4
MIRT505786 SATB1 SATB homeobox 1 2 4
MIRT510090 PPWD1 peptidylprolyl isomerase domain and WD repeat containing 1 2 4
MIRT520010 YY1 YY1 transcription factor 2 4
MIRT532552 TXNL1 thioredoxin like 1 2 2
MIRT533433 TRPS1 transcriptional repressor GATA binding 1 2 2
MIRT537459 FAM84B family with sequence similarity 84 member B 2 2
MIRT541825 SV2B synaptic vesicle glycoprotein 2B 2 2
MIRT543222 TMEM117 transmembrane protein 117 2 2
MIRT551088 DDX52 DExD-box helicase 52 2 2
MIRT551500 UGT2B4 UDP glucuronosyltransferase family 2 member B4 2 2
MIRT552326 ZNF791 zinc finger protein 791 2 2
MIRT553213 TXLNG taxilin gamma 2 2
MIRT554590 RRAGC Ras related GTP binding C 2 2
MIRT559004 CA8 carbonic anhydrase 8 2 2
MIRT559134 BTG3 BTG anti-proliferation factor 3 2 4
MIRT559409 GDNF glial cell derived neurotrophic factor 2 4
MIRT560678 SRFBP1 serum response factor binding protein 1 2 2
MIRT560954 POTED POTE ankyrin domain family member D 2 2
MIRT562856 C17orf58 chromosome 17 open reading frame 58 2 2
MIRT563003 MOCS2 molybdenum cofactor synthesis 2 2 2
MIRT564545 CCDC80 coiled-coil domain containing 80 2 2
MIRT566272 PTAR1 protein prenyltransferase alpha subunit repeat containing 1 2 2
MIRT566510 PAWR pro-apoptotic WT1 regulator 2 2
MIRT572103 EFNB2 ephrin B2 2 2
MIRT574576 NLGN4X neuroligin 4, X-linked 2 4
MIRT576574 Serpine1 serine (or cysteine) peptidase inhibitor, clade E, member 1 2 2
MIRT610815 POT1 protection of telomeres 1 2 2
MIRT624589 BCL11B B-cell CLL/lymphoma 11B 2 2
MIRT627567 SMAD6 SMAD family member 6 2 2
MIRT632675 MTX3 metaxin 3 2 2
MIRT689265 WDR83OS WD repeat domain 83 opposite strand 2 2
MIRT694310 COPB2 coatomer protein complex subunit beta 2 2 2
MIRT697721 USP8 ubiquitin specific peptidase 8 2 2
MIRT700209 RFWD3 ring finger and WD repeat domain 3 2 2
MIRT704399 CTSS cathepsin S 2 2
MIRT710665 CSTF2T cleavage stimulation factor subunit 2 tau variant 2 2
MIRT711953 SLC7A14 solute carrier family 7 member 14 2 2
MIRT712596 ADCYAP1 adenylate cyclase activating polypeptide 1 2 2
MIRT712692 TNFAIP2 TNF alpha induced protein 2 2 2
MIRT714171 PPP1R2 protein phosphatase 1 regulatory inhibitor subunit 2 2 2
MIRT715964 CES4A carboxylesterase 4A 2 2
MIRT722781 PDE3A phosphodiesterase 3A 2 2
MIRT724505 MSMO1 methylsterol monooxygenase 1 2 2

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