miRTarBase - #MIRT366903


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pre-miRNA Information
pre-miRNA hsa-mir-3675   
Genomic Coordinates chr1: 16858949 - 16859021
Description Homo sapiens miR-3675 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-3675-5p
Sequence 12| UAUGGGGCUUCUGUAGAGAUUUC |34
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1229940041 1 dbSNP
rs1184422098 2 dbSNP
rs768029583 3 dbSNP
rs202014433 6 dbSNP
rs774834919 7 dbSNP
rs1484376029 8 dbSNP
rs771338088 8 dbSNP
rs749521347 10 dbSNP
rs773421450 12 dbSNP
rs1250672393 14 dbSNP
rs769780471 15 dbSNP
rs781028022 16 dbSNP
rs1315377622 17 dbSNP
rs754885466 18 dbSNP
rs746860289 20 dbSNP
rs1330333643 23 dbSNP
Putative Targets

miRNA Expression profile
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol NONO   
Synonyms MRXS34, NMT55, NRB54, P54, P54NRB, PPP1R114
Description non-POU domain containing octamer binding
Transcript NM_001145408   
Other Transcripts NM_001145409 , NM_001145410 , NM_007363   
Expression
Putative miRNA Targets on NONO
3'UTR of NONO
(miRNA target sites are highlighted)		 
>NONO|NM_001145408|3'UTR
   1 TAAGTTGCAGTGTCTAGTTTCTCAAAACCCTTAAAAGAAGGACCCTTTTTGGACTAGCCAGAATTCTACCCTGGAAAAGT
  81 GTTAGGGATTCCTTCCAATAGTTAGATCTACCCTGCCTGTACTACTCTAGGGAGTATGCTGGAGGCAGAGGGCAAGGGAG
 161 GGGTGGTATTAAACAAGTCAATTCTGTGTGGTATATTGTTTAATCAGTTCTGTGTGGTGCATTCCTGAAGTCTCTAATGT
 241 GACTGTTGAGGGCCTGGGGAAACCATGGCAAAGTGGATCCAGTTAGAGCCCATTAATCTTGATCATTCCGGTTTTTTTTT
 321 TTTTTGTCCATCTTGTTTCATTTGCTTGCCCCGCCCCCGAGACGGAGTCTTACTCTGTCGCCCAGGCTGGAGTGTAGTGG
 401 CATGATCTCGGCTCACTGCAATCTCTGCCTCCCGGGTTCAAGCTTGTCCAGGTTGATCTTGAACTCCTGACCTCGTGATC
 481 TACCCACCTCGGCCTCCCAAAATGCTGGGATTACAGGGGTGAGCCACCGTGCCCAACCTCACTTGCTTCTTATCCTTACA
 561 CTCCCCCAGCCCCAGAGAAACTGCCACATACACCACAAAAACCAAACATCCCCCAATGACCTTAGCCCCATTGCTCCATT
 641 CACTCCCAGGTGAGAATTCAGGCAAACGTCCACAAAGGTCACAGGCAGCGTACATACGGTTCTGTTATACCCCATATATT
 721 ACCCCTTCATGTCCTAAAGAAGACATTTTCTCTTAGAGATTTTCATTTTAGTGTATCTTTAAAAAAAAATCTTGTGTTAA
 801 CTTGCCTCCATCTTTTTCTTGGGTGAGGACACCCAGGAATGACCCTTTTGTGTCTATGATGTTGCTGTTCACAGCTTTTC
 881 TTGATAGGCCTAGTACAATCTTGGGAACAGGGTTACTGTATACTGAAGGTCTGACAGTAGCTCTTAGACTCGCCTATCTT
 961 AGGTAGTCATGCTGTGCATTTTTTTTTTCATTGGTGTACTGTGTTTGATTTGTCTCATATATTTGGAGTTTTTCTGAAAA
1041 ATGGAGCAGTAATGCAGCATCAACCTATTAAAATACATTTTAAGCCTTTTAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuuUAGAGAUGU--CU----UCGGGGUAu 5'
             ||| |  ||  ||    |||||||| 
Target 5' aacATC-CCCCAATGACCTTAGCCCCATt 3'
 605 - 632 147.00 -13.70
2 
miRNA  3' cuuUAGAGAUGU-----CUUCGGGGUau 5'
             ||| :||||       |||||||  
Target 5' cttATCCTTACACTCCCCCAGCCCCAga 3'
 549 - 576 136.00 -14.70
3 
miRNA  3' cuuuAGA-GAUGUCUUCGGGGUAu 5'
              ||| :||:|    |||||| 
Target 5' cggtTCTGTTATA----CCCCATa 3'
 697 - 716 124.00 -13.80
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs886215260 11 dbSNP
rs1480920107 14 dbSNP
rs1201924122 15 dbSNP
rs756409552 24 dbSNP
rs780470033 29 dbSNP
rs764217339 31 dbSNP
rs901463158 61 dbSNP
rs780790265 64 dbSNP
rs1268828941 81 dbSNP
rs1005112783 82 dbSNP
rs1481509937 86 dbSNP
rs1251623326 94 dbSNP
rs762432678 96 dbSNP
rs1202971562 98 dbSNP
rs1464632280 99 dbSNP
rs149069408 114 dbSNP
rs751032985 120 dbSNP
rs145755066 128 dbSNP
rs968696319 140 dbSNP
rs1197887886 150 dbSNP
rs1000131078 153 dbSNP
rs757365853 156 dbSNP
rs1304460955 160 dbSNP
rs1392725909 161 dbSNP
rs1012415958 167 dbSNP
rs1332386571 171 dbSNP
rs1469800979 175 dbSNP
rs1427200927 182 dbSNP
rs1028246479 196 dbSNP
rs1466588543 219 dbSNP
rs11544186 250 dbSNP
rs1179952404 267 dbSNP
rs917740912 270 dbSNP
rs1410524787 283 dbSNP
rs970513749 302 dbSNP
rs1451216015 303 dbSNP
rs1294854254 308 dbSNP
rs1238564630 309 dbSNP
rs1393347828 311 dbSNP
rs1204181807 312 dbSNP
rs1349362797 312 dbSNP
rs34459863 312 dbSNP
rs369009210 312 dbSNP
rs565738506 312 dbSNP
rs1387768741 313 dbSNP
rs1240752460 317 dbSNP
rs954198693 321 dbSNP
rs1310528343 325 dbSNP
rs1452348194 326 dbSNP
rs761209617 326 dbSNP
rs986879893 326 dbSNP
rs113595508 327 dbSNP
rs1344223706 328 dbSNP
rs1412166936 329 dbSNP
rs1289097831 330 dbSNP
rs1316341596 331 dbSNP
rs1237168037 333 dbSNP
rs193158545 335 dbSNP
rs1357318775 336 dbSNP
rs1209066078 339 dbSNP
rs1266485250 340 dbSNP
rs1484010434 341 dbSNP
rs1182765243 345 dbSNP
rs1250431356 346 dbSNP
rs1455596529 353 dbSNP
rs1020098761 354 dbSNP
rs980686226 359 dbSNP
rs1244697580 360 dbSNP
rs1166279199 363 dbSNP
rs1446290939 364 dbSNP
rs1368722911 370 dbSNP
rs966847689 371 dbSNP
rs1206368575 372 dbSNP
rs1163367522 376 dbSNP
rs142711591 380 dbSNP
rs930979996 381 dbSNP
rs1048076431 393 dbSNP
rs1357767019 394 dbSNP
rs1309104131 396 dbSNP
rs1317539040 398 dbSNP
rs1246165788 400 dbSNP
rs1373226423 403 dbSNP
rs1316384736 408 dbSNP
rs749580677 410 dbSNP
rs1314906178 411 dbSNP
rs1302805070 412 dbSNP
rs1422917632 413 dbSNP
rs1136472 415 dbSNP
rs1475076747 422 dbSNP
rs749031358 424 dbSNP
rs1041248369 432 dbSNP
rs1343957651 434 dbSNP
rs1488349304 435 dbSNP
rs867789121 436 dbSNP
rs901347290 440 dbSNP
rs978247721 454 dbSNP
rs925479442 459 dbSNP
rs377322362 462 dbSNP
rs1292551147 471 dbSNP
rs754858083 472 dbSNP
rs1339360798 473 dbSNP
rs1183143805 475 dbSNP
rs1256180780 476 dbSNP
rs1422911397 483 dbSNP
rs1341227073 485 dbSNP
rs1282654315 487 dbSNP
rs1403413839 492 dbSNP
rs1367668960 496 dbSNP
rs1257775453 503 dbSNP
rs1324021422 511 dbSNP
rs936865006 522 dbSNP
rs996931940 529 dbSNP
rs1049986674 530 dbSNP
rs904757904 545 dbSNP
rs1432075179 548 dbSNP
rs916217829 549 dbSNP
rs1196644325 562 dbSNP
rs1481244412 563 dbSNP
rs1246902638 565 dbSNP
rs1000182270 584 dbSNP
rs1354512288 591 dbSNP
rs1032071559 592 dbSNP
rs1437638355 606 dbSNP
rs1271254461 608 dbSNP
rs1460901107 617 dbSNP
rs1319209054 622 dbSNP
rs1262652944 627 dbSNP
rs1046095155 628 dbSNP
rs1802558 637 dbSNP
rs778986608 639 dbSNP
rs1275698961 647 dbSNP
rs11544187 649 dbSNP
rs1441683903 653 dbSNP
rs891919196 656 dbSNP
rs886183133 660 dbSNP
rs1304688621 666 dbSNP
rs1402955931 668 dbSNP
rs1173693630 669 dbSNP
rs940485473 672 dbSNP
rs12836491 673 dbSNP
rs1194080066 675 dbSNP
rs1425205344 678 dbSNP
rs1176284699 686 dbSNP
rs745954996 687 dbSNP
rs2794 689 dbSNP
rs12835817 690 dbSNP
rs1231598962 691 dbSNP
rs1180887775 698 dbSNP
rs1458644490 699 dbSNP
rs772589952 704 dbSNP
rs1037459485 707 dbSNP
rs1024353577 709 dbSNP
rs1314046638 710 dbSNP
rs778971171 712 dbSNP
rs1452197652 717 dbSNP
rs1279351038 721 dbSNP
rs996021796 723 dbSNP
rs1348803883 726 dbSNP
rs1311259505 736 dbSNP
rs1447212868 738 dbSNP
rs748046670 739 dbSNP
rs1334644034 747 dbSNP
rs775901784 750 dbSNP
rs747662545 755 dbSNP
rs1450061952 764 dbSNP
rs1367605590 765 dbSNP
rs1359244196 766 dbSNP
rs1029344574 781 dbSNP
rs1207129704 781 dbSNP
rs1398654842 781 dbSNP
rs890401869 781 dbSNP
rs11544177 782 dbSNP
rs1228958219 784 dbSNP
rs1294555675 793 dbSNP
rs1019646050 794 dbSNP
rs1033624490 795 dbSNP
rs978172439 796 dbSNP
rs952587206 802 dbSNP
rs1215140235 806 dbSNP
rs958204373 807 dbSNP
rs747352142 809 dbSNP
rs1358489863 813 dbSNP
rs1312564185 816 dbSNP
rs769063174 817 dbSNP
rs1230028319 824 dbSNP
rs1379793573 831 dbSNP
rs916806661 840 dbSNP
rs1428004401 845 dbSNP
rs1201213102 857 dbSNP
rs983840890 859 dbSNP
rs1361852134 887 dbSNP
rs772842230 890 dbSNP
rs1298457472 901 dbSNP
rs1249578703 903 dbSNP
rs1385009396 911 dbSNP
rs908194122 913 dbSNP
rs1426135403 917 dbSNP
rs1415131145 918 dbSNP
rs1186041186 935 dbSNP
rs939667538 942 dbSNP
rs3208713 944 dbSNP
rs982184269 952 dbSNP
rs1419198433 953 dbSNP
rs1490247483 957 dbSNP
rs5981100 967 dbSNP
rs1427296249 968 dbSNP
rs1223472828 971 dbSNP
rs762524257 972 dbSNP
rs1212686562 979 dbSNP
rs1294810498 979 dbSNP
rs907540219 979 dbSNP
rs940411590 979 dbSNP
rs1404023508 983 dbSNP
rs1292198439 989 dbSNP
rs185418054 989 dbSNP
rs1469407933 990 dbSNP
rs1334783769 991 dbSNP
rs1391163444 994 dbSNP
rs1436024334 995 dbSNP
rs898980611 995 dbSNP
rs1288103540 997 dbSNP
rs922355869 999 dbSNP
rs1359524157 1000 dbSNP
rs1220886148 1006 dbSNP
rs1477093365 1013 dbSNP
rs773865295 1017 dbSNP
rs3199958 1019 dbSNP
rs189545709 1020 dbSNP
rs3208714 1021 dbSNP
rs931797338 1022 dbSNP
rs1050301820 1029 dbSNP
rs1267006600 1029 dbSNP
rs767462796 1029 dbSNP
rs1488698598 1034 dbSNP
rs1059295 1035 dbSNP
rs1250495521 1042 dbSNP
rs932836924 1047 dbSNP
rs752734372 1054 dbSNP
rs1049871582 1063 dbSNP
rs755961169 1076 dbSNP
rs936255861 1080 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 4841.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cuuuAGA-GAUGUCUUCGGGGUAu 5'
              ||| :||:|    |||||| 
Target 5' ---uUCUGUUAUA----CCCCAUa 3'
 		1 - 17
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM4903833
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_a
Location of target site NM_007363 | 3UTR | AAAGGUCACAGGCAGCGUACAUACGGUUCUGUUAUACCCCAUAUAUUACCCCUUCAUGUCCUAAAGAAGACAUUUUCUCUUAGAGAUUUUCAUUUUAGUGUAUCUUUAAAAAAAAAUCUUGUGUUAACUUGCCUCCAUCUUUUUCUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM4903835
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / CTL_TD_21_c
Location of target site NM_007363 | 3UTR | CAGCGUACAUACGGUUCUGUUAUACCCCAUAUAUUACCCCUUCAUGUCCUAAAGAAGACAUUUUCUCUUAGAGAUUUUCAUUUUAGUGUAUCUUUAAAAAAAAAUCUUGUGUUAACUUGCCUCCAUCUUUUUCUUGGGUGAGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM4903836
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_a
Location of target site NM_007363 | 3UTR | UGUUAUACCCCAUAUAUUACCCCUUCAUGUCCUAAAGAAGACAUUUUCUCUUAGAGAUUUUCAUUUUAGUGUAUCUUUAAAAAAAAAUCUUGUGUUAACUUGCCUCCAUCUUUUUCUUGGGUGAGGACACCCAGGAAUGACCCU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM4903837
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_b
Location of target site NM_007363 | 3UTR | GUUAUACCCCAUAUAUUACCCCUUCAUGUCCUAAAGAAGACAUUUUCUCUUAGAGAUUUUCAUUUUAGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 5 for dataset GSM4903838
Method / RBP HITS-CLIP / AGO
Cell line / Condition Dermal fibroblasts / 124_TD_21_c
Location of target site NM_007363 | 3UTR | CAGGUGAGAAUUCAGGCAAACGUCCACAAAGGUCACAGGCAGCGUACAUACGGUUCUGUUAUACCCCAUAUAUUACCCCUUCAUGUCCUAAAGAAGACAUUUUCUCUUAGAGAUUUUCAUUUUAGUGUAUCUUUAAAAAAAAAUCUUGUGUUAACUUGCCUCCAUCUUUUUCUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Accession Series GSE161239
CLIP-seq Viewer Link
CLIP-seq Support 6 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000276079.8 | 3UTR | UUCUGUUAUACCCCAUAUAUUACCCCUUCAUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
32 hsa-miR-3675-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT366903 NONO non-POU domain containing octamer binding 2 2
MIRT453894 DUSP18 dual specificity phosphatase 18 2 2
MIRT461725 ZNF426 zinc finger protein 426 2 2
MIRT464694 UBE2V1 ubiquitin conjugating enzyme E2 V1 2 2
MIRT465957 TMEM189-UBE2V1 TMEM189-UBE2V1 readthrough 2 2
MIRT466038 TMEM189 transmembrane protein 189 2 2
MIRT471546 PAX5 paired box 5 2 2
MIRT472813 MTMR12 myotubularin related protein 12 2 2
MIRT474099 LMBR1L limb development membrane protein 1 like 2 2
MIRT480205 CAD carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase 2 2
MIRT488268 HSP90AB1 heat shock protein 90 alpha family class B member 1 2 8
MIRT491222 MRPL34 mitochondrial ribosomal protein L34 2 2
MIRT494768 AP1G1 adaptor related protein complex 1 gamma 1 subunit 2 2
MIRT497228 MORC2 MORC family CW-type zinc finger 2 2 2
MIRT501676 PFN1 profilin 1 2 6
MIRT511831 H2AFX H2A histone family member X 2 4
MIRT513880 HNRNPUL1 heterogeneous nuclear ribonucleoprotein U like 1 2 4
MIRT519402 DNASE2 deoxyribonuclease 2, lysosomal 2 4
MIRT522627 MAP7D1 MAP7 domain containing 1 2 4
MIRT546998 PPP2CA protein phosphatase 2 catalytic subunit alpha 2 2
MIRT555119 PUM2 pumilio RNA binding family member 2 2 2
MIRT560380 TIMM8A translocase of inner mitochondrial membrane 8A 2 2
MIRT572188 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT634822 ASB6 ankyrin repeat and SOCS box containing 6 2 2
MIRT641149 DNMBP dynamin binding protein 2 2
MIRT647389 ZNF616 zinc finger protein 616 2 2
MIRT670851 SFT2D2 SFT2 domain containing 2 2 2
MIRT698600 TEX261 testis expressed 261 2 2
MIRT698691 TBPL1 TATA-box binding protein like 1 2 2
MIRT708725 PTPLAD2 3-hydroxyacyl-CoA dehydratase 4 1 1
MIRT718340 SYNDIG1L synapse differentiation inducing 1 like 2 2
MIRT725514 FBXO46 F-box protein 46 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-3675 Doxorubicin 31703 NSC123127 approved sensitive High Triple-Negative Breast Cancer cell line (MDA-MB-231, MDA-MB-468)
hsa-miR-3675-5p Cisplatin 5460033 NSC119875 approved resistant cell line (MGC-803)
hsa-miR-3675-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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