miRTarBase - #MIRT370117


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pre-miRNA Information
pre-miRNA hsa-mir-605   
Genomic Coordinates chr10: 51299573 - 51299655
Synonyms MIRN605, hsa-mir-605, MIR605
Description Homo sapiens miR-605 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-605-3p
Sequence 51| AGAAGGCACUAUGAGAUUUAGA |72
Evidence Experimental
Experiments Illumina
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 4 10 + 51299626 27587585, 28550310, 26028588, 26449202, 26487287, 29165639 MiREDiBase
A-to-I 14 10 + 51299636 29233923 MiREDiBase
A-to-I 20 10 + 51299642 18684997, 26449202, 27587585, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs759219082 5 dbSNP
rs1491224174 9 dbSNP
rs746611214 10 dbSNP
rs367648737 11 dbSNP
rs1359467239 14 dbSNP
rs1442565019 16 dbSNP
Putative Targets

Gene Information
Gene Symbol TRIB3   
Synonyms C20orf97, NIPK, SINK, SKIP3, TRB3
Description tribbles pseudokinase 3
Transcript NM_021158   
Expression
Putative miRNA Targets on TRIB3
3'UTR of TRIB3
(miRNA target sites are highlighted)		 
>TRIB3|NM_021158|3'UTR
   1 GACCACCCTACTACACGCTCAGCTGCCAACAGTGGATTGAGTTTGGGGGTAGCTCCAAGCCTTCTCCTGCCTCTGAACTG
  81 AGCCAAACCTTCAGTGCCTTCCAGAAGGGAGAAAGGCAGAAGCCTGTGTGGAGTGTGCTGTGTACACATCTGCTTTGTTC
 161 CACACACATGCAGTTCCTGCTTGGGTGCTTATCAGGTGCCAAGCCCTGTTCTCGGTGCTGGGAGTACAGCAGTGAGCAAA
 241 GGAGACAATATTCCCTGCTCACAGAGATGACAAACTGGCATCCTTGAGCTGACAACACTTTTCCATGACCATAGGTCACT
 321 GTCTACACTGGGTACACTTTGTACCAGTGTCGGCCTCCACTGATGCTGGTGCTCAGGCACCTCTGTCCAAGGACAATCCC
 401 TTTCACAAACAAACCAGCTGCCTTTGTATCTTGTACCTTTTCAGAGAAAGGGAGGTATCCCTGTGCCAAAGGCTCCAGGC
 481 CTCTCCCCTGCAACTCAGGACCCAAGCCCAGCTCACTCTGGGAACTGTGTTCCCAGCATCTCTGTCCTCTTGATTAAGAG
 561 ATTCTCCTTCCAGGCCTAAGCCTGGGATTTGGGCCAGAGATAAGAATCCAAACTATGAGGCTAGTTCTTGTCTAACTCAA
 641 GACTGTTCTGGAATGAGGGTCCAGGCCTGTCAACCATGGGGCTTCTGACCTGAGCACCAAGGTTGAGGGACAGGATTAGG
 721 CAGGGTCTGTCCTGTGGCCACCTGGAAAGTCCCAGGTGGGACTCTTCTGGGGACACTTGGGGTCCACAATCCCAGGTCCA
 801 TACTCTAGGTTTTGGATACCATGAGTATGTATGTTTACCTGTGCCTAATAAAGGAGAATTATGAAATAAAAAAAAAAAAA
 881 AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' agaUUUAGAGUAUCACGGAAGa 5'
             ||| ||:  ||||||||| 
Target 5' gccAAACCTT-CAGTGCCTTCc 3'
 82 - 102 162.00 -13.40
2 
miRNA  3' agaUUUAGAGUAUC-ACGGAAGa 5'
             ||| |    || ||||||: 
Target 5' aacAAACC----AGCTGCCTTTg 3'
 408 - 426 129.00 -6.70
3 
miRNA  3' agAUUUAGAGUAUCACGGAAGa 5'
            ||: || || |  |||||| 
Target 5' ggTAGCTC-CA-A--GCCTTCt 3'
 48 - 65 121.00 -10.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSM316128 1 COSMIC
COSN31521652 42 COSMIC
COSN30489792 57 COSMIC
COSN30501150 60 COSMIC
COSN30463704 90 COSMIC
COSN30147612 103 COSMIC
COSN19566766 205 COSMIC
COSN29354843 232 COSMIC
COSN10015369 247 COSMIC
COSN31961813 351 COSMIC
COSN31543297 464 COSMIC
COSN31482446 482 COSMIC
COSN30176944 550 COSMIC
COSN30177003 565 COSMIC
COSN31483422 595 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs771396793 8 dbSNP
rs776834364 12 dbSNP
rs759977026 16 dbSNP
rs759890273 17 dbSNP
rs765507830 18 dbSNP
rs1235908511 22 dbSNP
rs763062412 23 dbSNP
rs767371142 24 dbSNP
rs1357048045 26 dbSNP
rs1426151485 31 dbSNP
rs1477047761 33 dbSNP
rs780019539 38 dbSNP
rs1441997088 42 dbSNP
rs188020529 44 dbSNP
rs778272871 45 dbSNP
rs755972826 46 dbSNP
rs966171299 47 dbSNP
rs1466160557 49 dbSNP
rs766246372 53 dbSNP
rs900423317 61 dbSNP
rs556568862 62 dbSNP
rs1476305025 65 dbSNP
rs758744536 67 dbSNP
rs1321435934 75 dbSNP
rs6084315 90 dbSNP
rs977525080 91 dbSNP
rs996823999 95 dbSNP
rs1231058058 97 dbSNP
rs6051679 99 dbSNP
rs1028264674 102 dbSNP
rs952685720 110 dbSNP
rs1206557469 113 dbSNP
rs1442908833 127 dbSNP
rs780202035 130 dbSNP
rs936023029 132 dbSNP
rs1469360373 135 dbSNP
rs1182377595 136 dbSNP
rs1015638039 146 dbSNP
rs1467739910 161 dbSNP
rs192061190 172 dbSNP
rs1313039413 174 dbSNP
rs948610596 193 dbSNP
rs1045582422 194 dbSNP
rs535985314 195 dbSNP
rs939852649 196 dbSNP
rs928229395 204 dbSNP
rs1036774981 212 dbSNP
rs4352283 214 dbSNP
rs755089348 215 dbSNP
rs914930779 221 dbSNP
rs1418233844 229 dbSNP
rs1405530229 235 dbSNP
rs1410684385 249 dbSNP
rs1180350883 250 dbSNP
rs1290400509 253 dbSNP
rs1440223904 255 dbSNP
rs1343742711 257 dbSNP
rs1027911133 260 dbSNP
rs1211242068 262 dbSNP
rs868518762 264 dbSNP
rs889386390 272 dbSNP
rs6051682 284 dbSNP
rs1008198331 300 dbSNP
rs946328515 302 dbSNP
rs1345715311 316 dbSNP
rs1042540949 322 dbSNP
rs1202094739 324 dbSNP
rs923704772 329 dbSNP
rs944575156 336 dbSNP
rs142330335 339 dbSNP
rs1205467846 342 dbSNP
rs376258139 352 dbSNP
rs1370872943 353 dbSNP
rs544146672 360 dbSNP
rs527432999 361 dbSNP
rs558443192 366 dbSNP
rs748128309 369 dbSNP
rs769881992 370 dbSNP
rs1479239738 374 dbSNP
rs1368416943 379 dbSNP
rs578166429 399 dbSNP
rs1211334096 400 dbSNP
rs957405909 405 dbSNP
rs1198116969 429 dbSNP
rs1160213931 438 dbSNP
rs1420121739 443 dbSNP
rs1048942591 444 dbSNP
rs888449782 445 dbSNP
rs1394359868 453 dbSNP
rs777821030 459 dbSNP
rs1434337916 460 dbSNP
rs1016134661 464 dbSNP
rs915869369 466 dbSNP
rs1217762964 468 dbSNP
rs1264939892 468 dbSNP
rs1377697167 474 dbSNP
rs1347642767 476 dbSNP
rs11537607 477 dbSNP
rs567449867 492 dbSNP
rs563707076 500 dbSNP
rs770835467 509 dbSNP
rs183116089 522 dbSNP
rs928557639 523 dbSNP
rs1364311604 528 dbSNP
rs1299063378 529 dbSNP
rs1035199895 533 dbSNP
rs187050924 534 dbSNP
rs1400330445 535 dbSNP
rs939896193 548 dbSNP
rs959506757 550 dbSNP
rs991074650 561 dbSNP
rs879060394 562 dbSNP
rs192936575 571 dbSNP
rs1396235655 572 dbSNP
rs915464042 573 dbSNP
rs1036786322 583 dbSNP
rs1430745095 591 dbSNP
rs559537865 605 dbSNP
rs1363985576 614 dbSNP
rs968153899 615 dbSNP
rs773938324 617 dbSNP
rs1332846550 618 dbSNP
rs151258947 619 dbSNP
rs1251284119 620 dbSNP
rs1268306811 620 dbSNP
rs1341226383 621 dbSNP
rs551251219 622 dbSNP
rs1225284695 623 dbSNP
rs1320121606 636 dbSNP
rs889472198 640 dbSNP
rs944457107 641 dbSNP
rs2295491 646 dbSNP
rs1353871773 661 dbSNP
rs1310830070 664 dbSNP
rs530749662 668 dbSNP
rs1276477546 673 dbSNP
rs1489760173 680 dbSNP
rs931776239 682 dbSNP
rs1048973787 691 dbSNP
rs184131690 693 dbSNP
rs1459976806 706 dbSNP
rs1019650220 715 dbSNP
rs116353227 720 dbSNP
rs775085300 725 dbSNP
rs1415277968 726 dbSNP
rs3204117 728 dbSNP
rs1267461308 738 dbSNP
rs1037022015 740 dbSNP
rs1250370213 751 dbSNP
rs1194599708 757 dbSNP
rs1191688336 760 dbSNP
rs1459093607 761 dbSNP
rs3204118 765 dbSNP
rs1063081 768 dbSNP
rs546298462 774 dbSNP
rs1213205480 775 dbSNP
rs1332926750 777 dbSNP
rs566413053 778 dbSNP
rs1286211963 779 dbSNP
rs1246659493 782 dbSNP
rs1450601792 785 dbSNP
rs1170943514 786 dbSNP
rs1306122766 788 dbSNP
rs1035065807 801 dbSNP
rs189445101 804 dbSNP
rs765784366 807 dbSNP
rs1402449607 808 dbSNP
rs957455199 810 dbSNP
rs1012415292 818 dbSNP
rs1391781858 819 dbSNP
rs1294271241 822 dbSNP
rs1022592310 823 dbSNP
rs1393008047 824 dbSNP
rs766523952 828 dbSNP
rs1458679871 829 dbSNP
rs1023032803 832 dbSNP
rs978188414 834 dbSNP
rs1442072877 837 dbSNP
rs970492857 839 dbSNP
rs981463235 844 dbSNP
rs1435722126 852 dbSNP
rs149747048 853 dbSNP
rs961244072 859 dbSNP
rs1350321302 862 dbSNP
rs1259918689 867 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545217. RNA binding protein: AGO2. Condition:miR-7 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' agaUUUAGAGUAUCACGGAAGa 5'
             ||| ||:  ||||||||| 
Target 5' -ccAAACCUU-CAGUGCCUUCc 3'
 		1 - 20
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545217
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-7 transfection
Location of target site ENST00000217233.3 | 3UTR | CCAAACCUUCAGUGCCUUCC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
100 hsa-miR-605-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT061339 WEE1 WEE1 G2 checkpoint kinase 2 4
MIRT061584 BTG2 BTG anti-proliferation factor 2 2 6
MIRT076140 WDR81 WD repeat domain 81 2 2
MIRT079361 CCDC137 coiled-coil domain containing 137 2 2
MIRT079547 VAMP3 vesicle associated membrane protein 3 2 2
MIRT096242 CANX calnexin 2 2
MIRT243877 G3BP1 G3BP stress granule assembly factor 1 2 4
MIRT249186 AKIRIN1 akirin 1 2 8
MIRT273604 SP1 Sp1 transcription factor 2 2
MIRT316766 FOXC1 forkhead box C1 2 4
MIRT322410 PPP2R2A protein phosphatase 2 regulatory subunit Balpha 2 2
MIRT370117 TRIB3 tribbles pseudokinase 3 2 2
MIRT392725 UBN2 ubinuclein 2 2 2
MIRT406910 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT407440 CTDSP1 CTD small phosphatase 1 2 2
MIRT441887 RD3 retinal degeneration 3 2 4
MIRT444979 C15orf52 chromosome 15 open reading frame 52 2 2
MIRT445241 FOXD4 forkhead box D4 2 2
MIRT445500 FOXD4L5 forkhead box D4 like 5 2 2
MIRT445503 FOXD4L4 forkhead box D4 like 4 2 2
MIRT447025 FOXD4L1 forkhead box D4 like 1 2 2
MIRT447743 TMCC3 transmembrane and coiled-coil domain family 3 2 2
MIRT448761 HDX highly divergent homeobox 2 2
MIRT450003 HAX1 HCLS1 associated protein X-1 2 2
MIRT452830 FAM131B family with sequence similarity 131 member B 2 2
MIRT452872 LAX1 lymphocyte transmembrane adaptor 1 2 2
MIRT453506 ARRB1 arrestin beta 1 2 2
MIRT454169 HIST1H2BK histone cluster 1 H2B family member k 2 2
MIRT458742 CES2 carboxylesterase 2 2 2
MIRT459166 HSPA6 heat shock protein family A (Hsp70) member 6 2 21
MIRT460246 IL17RB interleukin 17 receptor B 2 4
MIRT460514 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT460698 RNF157 ring finger protein 157 2 2
MIRT461481 METTL1 methyltransferase like 1 2 2
MIRT462617 C20orf27 chromosome 20 open reading frame 27 2 4
MIRT463233 ZNF131 zinc finger protein 131 2 2
MIRT465699 TNPO2 transportin 2 2 8
MIRT466304 TIMM22 translocase of inner mitochondrial membrane 22 2 2
MIRT468957 RPS14 ribosomal protein S14 2 6
MIRT469571 RARA retinoic acid receptor alpha 2 2
MIRT469685 RAB5B RAB5B, member RAS oncogene family 2 2
MIRT470800 PMP22 peripheral myelin protein 22 2 2
MIRT471649 PANK2 pantothenate kinase 2 2 4
MIRT471722 OTUB1 OTU deubiquitinase, ubiquitin aldehyde binding 1 2 2
MIRT472281 NFIB nuclear factor I B 2 4
MIRT473680 MAPKBP1 mitogen-activated protein kinase binding protein 1 2 2
MIRT475859 H6PD hexose-6-phosphate dehydrogenase/glucose 1-dehydrogenase 2 2
MIRT477326 EPHA2 EPH receptor A2 2 2
MIRT477831 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT478572 CTNND1 catenin delta 1 2 4
MIRT479634 CD81 CD81 molecule 2 2
MIRT481950 ANKRD11 ankyrin repeat domain 11 2 2
MIRT483696 ZNF74 zinc finger protein 74 2 6
MIRT488798 MALT1 MALT1 paracaspase 2 2
MIRT489066 STARD3 StAR related lipid transfer domain containing 3 2 2
MIRT492533 PSMD11 proteasome 26S subunit, non-ATPase 11 2 2
MIRT492857 NRARP NOTCH regulated ankyrin repeat protein 2 2
MIRT496793 BTRC beta-transducin repeat containing E3 ubiquitin protein ligase 2 2
MIRT500122 ZNF106 zinc finger protein 106 2 4
MIRT505359 TMEM167A transmembrane protein 167A 2 2
MIRT506786 KLHL15 kelch like family member 15 2 6
MIRT510692 SRM spermidine synthase 2 6
MIRT515841 CEP104 centrosomal protein 104 2 4
MIRT516448 ADAMTS4 ADAM metallopeptidase with thrombospondin type 1 motif 4 2 4
MIRT528855 PKP1 plakophilin 1 2 2
MIRT533848 TET3 tet methylcytosine dioxygenase 3 2 2
MIRT539025 ATXN7L1 ataxin 7 like 1 2 4
MIRT542872 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT546543 SATB2 SATB homeobox 2 2 2
MIRT554114 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT560569 ZNF460 zinc finger protein 460 2 2
MIRT560796 EPM2AIP1 EPM2A interacting protein 1 2 2
MIRT562836 GCFC2 GC-rich sequence DNA-binding factor 2 2 2
MIRT563109 IFRD2 interferon related developmental regulator 2 2 2
MIRT564177 MRPL49 mitochondrial ribosomal protein L49 2 2
MIRT564283 ASB1 ankyrin repeat and SOCS box containing 1 2 2
MIRT564350 USP22 ubiquitin specific peptidase 22 2 2
MIRT565279 TNFRSF21 TNF receptor superfamily member 21 2 2
MIRT565338 TMEM104 transmembrane protein 104 2 2
MIRT565905 SCAMP2 secretory carrier membrane protein 2 2 2
MIRT567108 ITGB1 integrin subunit beta 1 2 2
MIRT567601 FANCF Fanconi anemia complementation group F 2 2
MIRT567779 DGAT2 diacylglycerol O-acyltransferase 2 2 2
MIRT568075 CENPQ centromere protein Q 2 2
MIRT624304 COL12A1 collagen type XII alpha 1 chain 2 2
MIRT644395 CDKL1 cyclin dependent kinase like 1 2 2
MIRT661547 ZNF674 zinc finger protein 674 2 4
MIRT670949 IRAK3 interleukin 1 receptor associated kinase 3 2 2
MIRT672951 AKAP5 A-kinase anchoring protein 5 2 2
MIRT697426 ZFP36 ZFP36 ring finger protein 2 2
MIRT700793 PIAS2 protein inhibitor of activated STAT 2 2 2
MIRT702657 ITGA3 integrin subunit alpha 3 2 2
MIRT708945 FZR1 fizzy and cell division cycle 20 related 1 2 2
MIRT713657 PLCE1 phospholipase C epsilon 1 2 2
MIRT719239 CYSLTR2 cysteinyl leukotriene receptor 2 2 2
MIRT719951 BLOC1S6 biogenesis of lysosomal organelles complex 1 subunit 6 2 2
MIRT722048 HLA-E major histocompatibility complex, class I, E 2 2
MIRT722201 URM1 ubiquitin related modifier 1 2 2
MIRT724790 C1D C1D nuclear receptor corepressor 2 2
MIRT734347 CYP2B6 cytochrome P450 family 2 subfamily B member 6 3 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-605 Anthranilamide-pyrazolo[1,5-a]pyrimidine NULL NULL Quantitative real-time PCR neuroblastoma cells 23992861 2013 up-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-605 Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-mir-605 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-605 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-605-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)

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