miRTarBase - #MIRT372293


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pre-miRNA Information
pre-miRNA hsa-mir-449b   
Genomic Coordinates chr5: 55170646 - 55170742
Description Homo sapiens miR-449b stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-449b-5p
Sequence 16| AGGCAGUGUAUUGUUAGCUGGC |37
Evidence Experimental
Experiments Microarray
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN8871076 12 COSMIC
COSN17153496 22 COSMIC
COSN31576772 22 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1322925717 3 dbSNP
rs769526811 10 dbSNP
rs10061133 12 dbSNP
rs1431829587 13 dbSNP
rs778042202 21 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol UBXN2B   
Synonyms p37
Description UBX domain protein 2B
Transcript NM_001077619   
Expression
Putative miRNA Targets on UBXN2B
3'UTR of UBXN2B
(miRNA target sites are highlighted)		 
>UBXN2B|NM_001077619|3'UTR
   1 TATTGTTCCTGTCCATGCAGTAGCATGTGGGAATAGATGATGTGCCGTATTAATAAGGACAATACTTCAGCATTAAAAAC
  81 AGCCAAATTATTTTTATTATTTTTACAGATAAATTTTGGTTTTATTGTTATTCTGTCTTCCAATCTGAATATAGACAAAT
 161 TTGGATTAGGAATAGACCTTGAGATAAGTATGTTTGAGTTTTTAGTTGAAGGACTGGCTTATGTTGATAGTTTTTGGATT
 241 TCTAGGCAAATGAGTTGTTACATGCTTAGTGTTAATGTAACAACATTTGTTTGCAGAGAAAAATGAACAAAACCCCTTTT
 321 TGATAAATGCATTTGGTAAAATTTGCACTAAAGTTTCTTGATGCAGCATTGACCAACAGCCATTAAGAAATCTTTTGATC
 401 AAATAAGTTGAAAATTTGTCTATAATATATACTGAAACGTGTCTTTTGATTTTGAAATTGTTTGATCATACAATAATTAT
 481 TTCTCCTATTAAGATTTTACACATCCTTTTTACTTACTGATTTAGATATATTACTAGTATCAGAAACTACAGTTTTGCCT
 561 TGTATTTTACAGAATTATGACTGTTGTGAACTTAAACAGAAACACATAAAGGTCAGCAATTCTTTTTTTTTTTTTTTTTG
 641 ATATGGAGTTTTGCTCTTGTTGCCCAGGCTGGAGTGCAATGGCATAATTTCTGCTCACCGCAACCTCCGCCTCCCAGGTT
 721 CAAAAGATTCTCCTGCCTTAGCCTCCCAAGTAGCTGGGATTACAGGCATGCGCCACCATGCCTGGCTAATTTTTGTACTT
 801 TTGCTAGAGACAGCGTTTCTCTGTGTTGATCAGGCTGGTCTCGAACTCCGAACCTCAGGTGATCCACCCACCTCAGCCTC
 881 CCAAAGTGCTGGGATTACAGGCATGAGCCACCACGCCCAGCCTAAAGGTCAGCAGTTCTTAAGAAGATATGGTAAACAGC
 961 AACAATATTTTAAAATCAAGTAATTACAGTTCCTCCCAGAGCTTGCGTTGATCACATTCATTTATTCATTCAACACATTT
1041 TTCTAGGAAACTCACTGTATACACTAAACACTATTCTGTGTGCTCAACCTAGAATGTCTTCTCCAGAACAAGACTAGTGT
1121 AGAAATACAGGAATGTAAATTCTGTCAGACGGACTAGATCTAAAGAATTACCAGCATAAATGTTTGCATTTCTGCTGAAG
1201 CCAGAAGCTTTTCCTTCTTCCTAGACACCATTTCATCCTTAATTATTACTTCTGGTTAGTTTTCCATTGCCACCATAACA
1281 AGTTACAAAATGTGGCTTAAAATAGCACAAATTTATTATCTTCACAATTCTGTAGGTTAGGAGTCCAGGTTAAGAGTTTC
1361 GCGGTGCCAAGATCAATTTGTTGGCAGGGTTGCATTCTGTTAGGAGGCTCTACAGGAGAATCATTTCCTTGTCATTCCAC
1441 CTTCTACAGGACATCCTCATTCCTTGGCTTGTGACCTCCTTCTTCCATCTTAAAAACCAGTGCTGTTTCATCTCTATGAC
1521 CCTTCTGTTACCACATCTCTCTGACACCAGTGTGGAGAGGTTCTCTGCAGGACTCATGATTAAATGAGGCCCACCGGATA
1601 TCCAATCTAGGCTTATCTCCTTGTCTTGAAATCCATAGTAACCTTAATTACATCTGCAAAATCTCTTTTACCATCTAAGG
1681 TTACATACAGGTTTGGAGATTAGGACATTAACATTTTACATGGAACATTATTCTTGCCTACTACAGTTCCCACCCACCCC
1761 CCGCTCCACTCCTGTGTTAAAGATTCAGATTCATCACAAATAAATTTACATCACTCATAGGTGCTCAAAAGTCACAATCC
1841 ATTATTACAGCATCAACTCTAAATCCAAAATCTTATCTGAGTCTCACCAACTCAAAAGTCTCAAATCTCACATTGAAGCC
1921 ATCTAAATTAAGTTTGGGAGAGGATCTGTGTGTGATTTCTGGGACATAATTCCAACTGTGCACTTGTGAACCTAGAAAAC
2001 AAGTTATCTGTTCCCAAGTATGATGGCATGACAGGCAGACAATAATAGTTACACACGTTCCTGTTCAAAAAGCAGAAACA
2081 GATGGAAAAAGGAGCCATCAGCACCAATCAATTTACAAAACCAGCGAGGCACCCTTCTTTAAGTTTCAAGGCCTGGGAGT
2161 AATCTTCAGCTCACTGCTGTTCTCTGGGCTTGTTGACTGTCTCAGAGTCATCTTTACTTTTTCACAAAAGGTAGCACACG
2241 TTTGCAGCTGAGTATCAACTTATCAGTTTGTTCTTCTTTTATATTCTCTAAAGCTTTCTGTTAAAAATGGTGGTGCTTCT
2321 GCTGCTATAACGTTGTCAAGAAACTTGTGGGTCTTTTACATATGTCACAGGGATGCACTCATTTAGATAGGAGGCTCCTC
2401 ACGTATCTTTCCTGGAAAATCCTGTCTCTGTTTTTGGCTTTTTCTGAAATAGCTGAGAGGATCTATGATTCACACCCTTA
2481 ATATCTTCAAAGAGTCTTGTGTGTGACCTGATATTCAGACCTTTTGATGTTTCTGAAGTATTAGCAAAAGGTTATACAGC
2561 CATATCTTCATCACTTTCTCTAGAGTAAAGGCTGTCCTGACGGTGAATCTTAGTTTTAGTGGCTTTTGCCATTTGAATAG
2641 GCCGCGAATTTCCCAAATCATCAAGTCCTGGTTTCTTTATATTTAACAGGTCTTCCCTCAATCTACCTCTTTCCACATTT
2721 TACTATAATCAGCAAGAAGACAGCAGGCTGTACCTTCCACAGCTTGCTTGGAAATATCCTCAGCTAAATATTGAAGTCAT
2801 CACTTAAAAGTTCTGCTTTACACATAACGGCAGGACACAACTCAGCTTAGCTTTTCGCCACTATGTAACAAGGACTCCTT
2881 TCCTCCACTTCTCCAGTAACATATTCCTCATTTTTTACCAACAGTCTATTCATGATGATTTAGATATTCTATGGCAATCG
2961 AGGTATTCTCTATTATGCTCCTTTCTTCAAGGCCGCCCTAGCATTAACATTCCATATTTCTACTAACAGTCTGTTTAAGG
3041 CAGTTTAGCTTCTTTTCTGGCATGCTCCTCAGAATTCTTCCAGCCTCCACCTACTGCCCAATTCCAGAGCCACTTTTCTA
3121 CTTTTAGGTATTTGTTACAGCAGCACCTCAAGTACCTAGAAAACTCTTTTATGCCTGCTTCTCTGCCAGATGACTTGAAT
3201 ATGGTACTAGATTTGGAATTCACCTTTCTCCAGGGTCACTGTTTATTTCAAAGAGGTGAATTTACCTGTGCTAGGGTTTT
3281 CACACTGGGAGTGCTACCAGAACTACCACAGGATGAAAGTGGTGAGCCCACCACTGCAGAGAAGTTTTCTCAGTGCCGTA
3361 ATATAGAGGAATTCTCAAAATAAGCCCTACTCCTTTTCACTTACTGAAAACAACTTGGATAATGTGTAACAGCCAGCCCC
3441 ATTTCAAAAAGATTACCAGGGGTAAAACAACTTTTTCATGGGTCAAAATCATCTTCCGAAGAAAATGATTTCTTAAAAGA
3521 ATTGAACATTGTAAATCAAAGGGCATTGTCCTGTTTTGGATTAACAAAACAGGAAAAATAACCAATCCTTGTAAAATTAT
3601 TTGAAATTTTCTTGTTTTTATCAGTTGAGTGCCTATAGATGCACATACAAAAACAACTGCCATTTTTGTATATAATAGTC
3681 TTCCAAGATAGAGATTTACATTAGGAGAGAATTAAACATCCAGGAGGGATGAACAGTATTTCATGTGTGCTATGTAGTGT
3761 TTTGCTTCATTGAGAGTCATTTTCATGAATTATTTTTACTACTGCAGTCATCTTAAATTTATAATCATCTCAAAAAAGAT
3841 GTCACAATGAACAGACAACCATCTGTGAGGTCAGTCATTTTGCATGATGTATGTAATCAAAAAGTTTGAAATGTCTGCTT
3921 ACTAATAAAGAATGTTTTCACTGAAACTTAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cgGUCGAUUGUUAUGUGACGGa 5'
            ::|:||::  | ||:|||| 
Target 5' tcTGGTTAGTTTTCCATTGCCa 3'
 1251 - 1272 140.00 -15.60
2 
miRNA  3' cggUCGAUU----GUUAUGUGACGGa 5'
             || |||    ||:  ||||||: 
Target 5' gggAG-TAATCTTCAGCTCACTGCTg 3'
 2155 - 2179 132.00 -13.01
3 
miRNA  3' cgGUC-GAUUGUUAUGUGACGGa 5'
            ||| ||  | |  :|||||| 
Target 5' tcCAGCCT--CCACCTACTGCCc 3'
 3079 - 3099 132.00 -17.20
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30454535 15 COSMIC
COSN30184684 47 COSMIC
COSN31544038 95 COSMIC
COSN20468289 105 COSMIC
COSN31557883 159 COSMIC
COSN24629629 343 COSMIC
COSN15798912 968 COSMIC
COSN20105526 1034 COSMIC
COSN31596211 1060 COSMIC
COSN7674672 1151 COSMIC
COSN22640798 1658 COSMIC
COSN9662473 2122 COSMIC
COSN2282277 2657 COSMIC
COSN32064343 2887 COSMIC
COSN6700779 3207 COSMIC
COSN23703339 3211 COSMIC
COSN28749778 3357 COSMIC
COSN31556402 3385 COSMIC
COSN31534881 3429 COSMIC
COSN18856101 3457 COSMIC
COSN22443202 3538 COSMIC
COSN31485798 3538 COSMIC
COSN31566677 3609 COSMIC
COSN31521280 3610 COSMIC
COSN8519178 3689 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1161152584 1 dbSNP
rs771560356 2 dbSNP
rs1262402702 3 dbSNP
rs775018211 6 dbSNP
rs747885892 8 dbSNP
rs760253071 14 dbSNP
rs1325361155 18 dbSNP
rs1486907047 20 dbSNP
rs763942670 24 dbSNP
rs776388810 25 dbSNP
rs1187224490 26 dbSNP
rs1158676818 28 dbSNP
rs1213553725 30 dbSNP
rs1359419939 31 dbSNP
rs1247467085 32 dbSNP
rs761779891 47 dbSNP
rs188122027 48 dbSNP
rs750328273 52 dbSNP
rs1335269490 53 dbSNP
rs1264531907 55 dbSNP
rs539648437 58 dbSNP
rs1471254155 60 dbSNP
rs1407224157 61 dbSNP
rs1170406595 63 dbSNP
rs537559639 72 dbSNP
rs771857253 83 dbSNP
rs1202423081 97 dbSNP
rs1036528073 100 dbSNP
rs569731376 101 dbSNP
rs1181619449 106 dbSNP
rs1193685771 114 dbSNP
rs1263749090 118 dbSNP
rs1203537768 122 dbSNP
rs1305596518 134 dbSNP
rs545090502 135 dbSNP
rs114860212 144 dbSNP
rs1358045149 147 dbSNP
rs561775907 148 dbSNP
rs1312293606 149 dbSNP
rs572106367 160 dbSNP
rs765044081 173 dbSNP
rs1001167808 174 dbSNP
rs1417541601 177 dbSNP
rs1054566030 178 dbSNP
rs145723266 187 dbSNP
rs1334734895 192 dbSNP
rs1391517117 206 dbSNP
rs1383243792 219 dbSNP
rs1383393644 223 dbSNP
rs1165539452 224 dbSNP
rs1445372895 231 dbSNP
rs1318141864 243 dbSNP
rs1010594528 256 dbSNP
rs1020104649 265 dbSNP
rs56072294 270 dbSNP
rs1234417403 271 dbSNP
rs768328724 272 dbSNP
rs1284819909 283 dbSNP
rs1490085331 290 dbSNP
rs1289222586 309 dbSNP
rs1323742381 310 dbSNP
rs1222405720 313 dbSNP
rs965820496 314 dbSNP
rs1359584117 317 dbSNP
rs997321480 318 dbSNP
rs1486837347 319 dbSNP
rs1205635243 324 dbSNP
rs541169484 325 dbSNP
rs1445075237 330 dbSNP
rs1299107474 331 dbSNP
rs1404798885 346 dbSNP
rs182035559 351 dbSNP
rs984800139 361 dbSNP
rs1425342641 362 dbSNP
rs909244133 374 dbSNP
rs752647335 377 dbSNP
rs1480213276 378 dbSNP
rs1417251218 383 dbSNP
rs186287260 405 dbSNP
rs972754451 417 dbSNP
rs758379577 421 dbSNP
rs949492877 423 dbSNP
rs1224293928 428 dbSNP
rs767570184 429 dbSNP
rs1045266937 432 dbSNP
rs1288800845 435 dbSNP
rs535576487 439 dbSNP
rs937116187 440 dbSNP
rs1304090684 442 dbSNP
rs190752951 446 dbSNP
rs1308403477 449 dbSNP
rs1344065244 458 dbSNP
rs756272198 458 dbSNP
rs1054110625 461 dbSNP
rs183756736 462 dbSNP
rs1280879507 486 dbSNP
rs1384270971 488 dbSNP
rs1287195160 489 dbSNP
rs1318196913 504 dbSNP
rs1455472842 508 dbSNP
rs1189071789 515 dbSNP
rs1346870802 516 dbSNP
rs1159869599 533 dbSNP
rs1239061712 541 dbSNP
rs1426970301 542 dbSNP
rs555381984 545 dbSNP
rs1201067249 549 dbSNP
rs1009916972 550 dbSNP
rs1260692305 552 dbSNP
rs67257878 558 dbSNP
rs1486587869 559 dbSNP
rs377434938 560 dbSNP
rs1224494169 563 dbSNP
rs186656161 577 dbSNP
rs1321790320 578 dbSNP
rs1265399996 580 dbSNP
rs1269301624 584 dbSNP
rs1224282956 588 dbSNP
rs1326070240 589 dbSNP
rs1293776569 594 dbSNP
rs1383966867 594 dbSNP
rs1490263756 594 dbSNP
rs1321087504 598 dbSNP
rs1469244718 606 dbSNP
rs1403548479 607 dbSNP
rs1178321861 609 dbSNP
rs901768234 611 dbSNP
rs1372117873 617 dbSNP
rs1190624557 620 dbSNP
rs1429730188 622 dbSNP
rs1229918479 623 dbSNP
rs200336686 623 dbSNP
rs71248196 623 dbSNP
rs71557725 623 dbSNP
rs879248917 623 dbSNP
rs1197530745 624 dbSNP
rs771680097 628 dbSNP
rs1314473149 629 dbSNP
rs1450629723 640 dbSNP
rs891872697 641 dbSNP
rs1158416236 644 dbSNP
rs528101489 645 dbSNP
rs1362601759 646 dbSNP
rs1395541298 647 dbSNP
rs1165741604 648 dbSNP
rs1427075112 653 dbSNP
rs1164670752 654 dbSNP
rs1365328742 655 dbSNP
rs1423682602 657 dbSNP
rs1162370727 659 dbSNP
rs1300915614 660 dbSNP
rs148933248 663 dbSNP
rs1437559310 666 dbSNP
rs1391491083 674 dbSNP
rs1305630306 676 dbSNP
rs953460539 678 dbSNP
rs1006739649 680 dbSNP
rs1291394739 683 dbSNP
rs147055282 684 dbSNP
rs1361729225 694 dbSNP
rs1292310671 696 dbSNP
rs1317019932 697 dbSNP
rs1358469169 700 dbSNP
rs962331653 701 dbSNP
rs1326610740 704 dbSNP
rs1392986165 704 dbSNP
rs1253321268 705 dbSNP
rs1302200158 709 dbSNP
rs1422173309 710 dbSNP
rs1386581393 719 dbSNP
rs972094210 726 dbSNP
rs112555566 728 dbSNP
rs1248483830 730 dbSNP
rs556514639 731 dbSNP
rs1473153873 736 dbSNP
rs1447041320 741 dbSNP
rs1268414508 742 dbSNP
rs971002871 744 dbSNP
rs1490845882 745 dbSNP
rs1184750135 746 dbSNP
rs980935365 747 dbSNP
rs1210284913 761 dbSNP
rs1349863201 766 dbSNP
rs557993714 769 dbSNP
rs1240891405 770 dbSNP
rs1385087952 772 dbSNP
rs71521415 773 dbSNP
rs1402733537 782 dbSNP
rs543185320 790 dbSNP
rs990280106 793 dbSNP
rs535820336 796 dbSNP
rs914344454 800 dbSNP
rs1383416068 802 dbSNP
rs1462155745 805 dbSNP
rs945662800 809 dbSNP
rs1041388207 816 dbSNP
rs1197462443 820 dbSNP
rs1481542986 821 dbSNP
rs1397491913 825 dbSNP
rs901758327 839 dbSNP
rs779197332 840 dbSNP
rs1192542570 841 dbSNP
rs1454052648 843 dbSNP
rs933278321 844 dbSNP
rs1262287018 846 dbSNP
rs1050199814 850 dbSNP
rs1243538904 851 dbSNP
rs1297415814 855 dbSNP
rs888976037 860 dbSNP
rs1324208817 868 dbSNP
rs1006065981 871 dbSNP
rs1016723112 876 dbSNP
rs748679129 877 dbSNP
rs1308353879 881 dbSNP
rs1204079641 884 dbSNP
rs1405721230 886 dbSNP
rs146995083 888 dbSNP
rs572365314 892 dbSNP
rs1204324826 902 dbSNP
rs541032421 911 dbSNP
rs557704504 915 dbSNP
rs1025021252 916 dbSNP
rs970952247 919 dbSNP
rs1190361103 931 dbSNP
rs772775838 935 dbSNP
rs981051379 937 dbSNP
rs772777808 943 dbSNP
rs1188705121 947 dbSNP
rs1313782070 951 dbSNP
rs1420650249 956 dbSNP
rs1278847856 957 dbSNP
rs1428815009 960 dbSNP
rs578047225 961 dbSNP
rs1336809502 964 dbSNP
rs1169313003 966 dbSNP
rs1281318007 976 dbSNP
rs1435266329 977 dbSNP
rs1382676944 981 dbSNP
rs1033946657 987 dbSNP
rs556755665 1007 dbSNP
rs1470682311 1008 dbSNP
rs1328370705 1028 dbSNP
rs1408435101 1029 dbSNP
rs989665505 1030 dbSNP
rs144200214 1031 dbSNP
rs74274677 1031 dbSNP
rs754336959 1031 dbSNP
rs945849226 1034 dbSNP
rs977053234 1036 dbSNP
rs563379235 1037 dbSNP
rs1445704549 1052 dbSNP
rs922964420 1057 dbSNP
rs1237849176 1059 dbSNP
rs1203295715 1063 dbSNP
rs1362397669 1064 dbSNP
rs1435710830 1065 dbSNP
rs879599958 1066 dbSNP
rs1276404239 1067 dbSNP
rs1228463972 1072 dbSNP
rs933224444 1075 dbSNP
rs1313506123 1079 dbSNP
rs1213708177 1085 dbSNP
rs1380265555 1086 dbSNP
rs1279333955 1089 dbSNP
rs1293723733 1090 dbSNP
rs1325873189 1100 dbSNP
rs1440540672 1103 dbSNP
rs529084740 1105 dbSNP
rs1356475812 1109 dbSNP
rs542798562 1117 dbSNP
rs1308911282 1118 dbSNP
rs770655465 1120 dbSNP
rs1424057208 1124 dbSNP
rs1363819999 1134 dbSNP
rs1161530954 1142 dbSNP
rs559696704 1150 dbSNP
rs1262562284 1151 dbSNP
rs1460413641 1152 dbSNP
rs1468452041 1163 dbSNP
rs1253485491 1172 dbSNP
rs1218551420 1177 dbSNP
rs889035904 1181 dbSNP
rs941825367 1193 dbSNP
rs1185091417 1198 dbSNP
rs1421060377 1203 dbSNP
rs551267182 1205 dbSNP
rs56365831 1207 dbSNP
rs191548287 1214 dbSNP
rs1343650297 1216 dbSNP
rs1295360880 1220 dbSNP
rs1427974592 1228 dbSNP
rs528362067 1229 dbSNP
rs59493755 1250 dbSNP
rs71521416 1257 dbSNP
rs1350377887 1265 dbSNP
rs1161209854 1266 dbSNP
rs1398700613 1267 dbSNP
rs1345658759 1275 dbSNP
rs1182379273 1291 dbSNP
rs906505272 1293 dbSNP
rs1266401770 1296 dbSNP
rs571201270 1311 dbSNP
rs1429801374 1319 dbSNP
rs76507813 1323 dbSNP
rs1347668764 1329 dbSNP
rs1405762338 1331 dbSNP
rs186962522 1333 dbSNP
rs1033890911 1336 dbSNP
rs1331596649 1339 dbSNP
rs1282799561 1341 dbSNP
rs958321016 1347 dbSNP
rs1321659436 1349 dbSNP
rs1303745715 1350 dbSNP
rs1387397137 1358 dbSNP
rs990044772 1361 dbSNP
rs1021159913 1362 dbSNP
rs116310847 1363 dbSNP
rs1390830805 1365 dbSNP
rs1159610547 1366 dbSNP
rs1285600414 1372 dbSNP
rs1375538489 1374 dbSNP
rs1177828601 1375 dbSNP
rs1433210539 1389 dbSNP
rs1316803144 1390 dbSNP
rs1185217836 1413 dbSNP
rs1466637758 1415 dbSNP
rs866637890 1416 dbSNP
rs1249257783 1418 dbSNP
rs548911645 1429 dbSNP
rs1271469650 1438 dbSNP
rs1490755366 1441 dbSNP
rs567201963 1442 dbSNP
rs776375001 1442 dbSNP
rs1199885712 1455 dbSNP
rs1293531369 1460 dbSNP
rs1267996439 1463 dbSNP
rs1476991408 1468 dbSNP
rs985769253 1470 dbSNP
rs910454001 1471 dbSNP
rs1451590206 1479 dbSNP
rs941997739 1482 dbSNP
rs570199850 1484 dbSNP
rs1037921121 1488 dbSNP
rs1466232037 1506 dbSNP
rs1372209358 1515 dbSNP
rs919127120 1517 dbSNP
rs536048688 1519 dbSNP
rs370132086 1523 dbSNP
rs1408030950 1530 dbSNP
rs759150096 1532 dbSNP
rs929140280 1534 dbSNP
rs1156400092 1535 dbSNP
rs1046496345 1536 dbSNP
rs1367059815 1536 dbSNP
rs1258718706 1558 dbSNP
rs1424982683 1561 dbSNP
rs1480422279 1578 dbSNP
rs1302913479 1588 dbSNP
rs1207340914 1594 dbSNP
rs906616493 1596 dbSNP
rs555497846 1597 dbSNP
rs1444954715 1602 dbSNP
rs1338410669 1606 dbSNP
rs1280678999 1613 dbSNP
rs1314600322 1630 dbSNP
rs1396453768 1634 dbSNP
rs1395298444 1643 dbSNP
rs1372637117 1646 dbSNP
rs1431065560 1654 dbSNP
rs1370661508 1658 dbSNP
rs1163442863 1661 dbSNP
rs1472099109 1662 dbSNP
rs1002168737 1666 dbSNP
rs1055163425 1674 dbSNP
rs1188652835 1677 dbSNP
rs1418900975 1678 dbSNP
rs894044734 1681 dbSNP
rs1483388808 1682 dbSNP
rs1291134128 1687 dbSNP
rs1220435012 1690 dbSNP
rs561541937 1691 dbSNP
rs566045515 1708 dbSNP
rs1360431177 1714 dbSNP
rs534955567 1720 dbSNP
rs557755334 1723 dbSNP
rs1334985200 1727 dbSNP
rs775206480 1727 dbSNP
rs1286021019 1734 dbSNP
rs1411295535 1738 dbSNP
rs1350496399 1739 dbSNP
rs1301985347 1742 dbSNP
rs1403145320 1743 dbSNP
rs1393474332 1744 dbSNP
rs1290727440 1746 dbSNP
rs1164373753 1750 dbSNP
rs1449692041 1752 dbSNP
rs1453432848 1752 dbSNP
rs374631357 1753 dbSNP
rs1473036752 1756 dbSNP
rs1196822635 1757 dbSNP
rs1268516553 1757 dbSNP
rs1453444429 1758 dbSNP
rs1269330167 1761 dbSNP
rs762811465 1763 dbSNP
rs117306192 1764 dbSNP
rs118104017 1766 dbSNP
rs867281918 1768 dbSNP
rs4599797 1769 dbSNP
rs1282287136 1770 dbSNP
rs1444844788 1771 dbSNP
rs368325148 1775 dbSNP
rs1382158810 1783 dbSNP
rs954496639 1789 dbSNP
rs1161803600 1806 dbSNP
rs1458137407 1810 dbSNP
rs1388976560 1811 dbSNP
rs1412020727 1817 dbSNP
rs765564890 1817 dbSNP
rs1330074066 1842 dbSNP
rs1171073890 1845 dbSNP
rs1354468700 1847 dbSNP
rs371678833 1849 dbSNP
rs138203376 1858 dbSNP
rs1383680685 1860 dbSNP
rs542859968 1866 dbSNP
rs567098504 1867 dbSNP
rs559562234 1869 dbSNP
rs141803286 1872 dbSNP
rs1465206879 1876 dbSNP
rs754072056 1877 dbSNP
rs755216374 1878 dbSNP
rs1217127962 1884 dbSNP
rs929086618 1885 dbSNP
rs1046269148 1891 dbSNP
rs928023564 1897 dbSNP
rs938114505 1902 dbSNP
rs1436231129 1910 dbSNP
rs564771319 1914 dbSNP
rs1405841021 1920 dbSNP
rs545308365 1925 dbSNP
rs1332373465 1944 dbSNP
rs1416388523 1945 dbSNP
rs763185391 1945 dbSNP
rs564768333 1948 dbSNP
rs1055515976 1963 dbSNP
rs150505940 1968 dbSNP
rs1447786841 1975 dbSNP
rs1196728501 1976 dbSNP
rs550259541 1978 dbSNP
rs779335388 1982 dbSNP
rs1011336161 1983 dbSNP
rs1236683120 1988 dbSNP
rs1244414783 1993 dbSNP
rs1461403764 2001 dbSNP
rs1207836617 2008 dbSNP
rs561045952 2014 dbSNP
rs1443772398 2020 dbSNP
rs868765277 2047 dbSNP
rs1278950450 2048 dbSNP
rs1203767993 2054 dbSNP
rs1042621538 2056 dbSNP
rs139443442 2057 dbSNP
rs902766790 2058 dbSNP
rs1366366919 2059 dbSNP
rs1282787113 2068 dbSNP
rs1450707169 2073 dbSNP
rs1476556176 2080 dbSNP
rs1168847890 2086 dbSNP
rs549185410 2086 dbSNP
rs1427847268 2088 dbSNP
rs1419320725 2090 dbSNP
rs1464499021 2097 dbSNP
rs1170336280 2098 dbSNP
rs748523213 2103 dbSNP
rs1406866132 2104 dbSNP
rs1029824612 2105 dbSNP
rs954444423 2110 dbSNP
rs758913419 2117 dbSNP
rs191433498 2123 dbSNP
rs535028277 2126 dbSNP
rs963055941 2127 dbSNP
rs1276164644 2134 dbSNP
rs778443692 2136 dbSNP
rs1321631259 2158 dbSNP
rs1288410425 2168 dbSNP
rs1230357117 2173 dbSNP
rs1380377157 2177 dbSNP
rs1228509414 2178 dbSNP
rs1287899621 2183 dbSNP
rs551657684 2185 dbSNP
rs149250312 2189 dbSNP
rs111448387 2191 dbSNP
rs537463786 2199 dbSNP
rs1424149569 2200 dbSNP
rs1349195458 2210 dbSNP
rs927803897 2212 dbSNP
rs938063634 2219 dbSNP
rs764232208 2230 dbSNP
rs1264953273 2232 dbSNP
rs990889449 2236 dbSNP
rs915329493 2238 dbSNP
rs1199393137 2240 dbSNP
rs946699949 2247 dbSNP
rs1042817207 2248 dbSNP
rs1245437341 2253 dbSNP
rs1224446252 2259 dbSNP
rs1253546051 2264 dbSNP
rs182129966 2266 dbSNP
rs1267886756 2271 dbSNP
rs902770703 2271 dbSNP
rs1331451437 2274 dbSNP
rs934268994 2281 dbSNP
rs1375702219 2283 dbSNP
rs533469333 2285 dbSNP
rs1291658554 2291 dbSNP
rs1438534624 2296 dbSNP
rs1395218012 2299 dbSNP
rs889925091 2301 dbSNP
rs1007490378 2307 dbSNP
rs1262878832 2308 dbSNP
rs1477062421 2311 dbSNP
rs1017317637 2313 dbSNP
rs187964215 2314 dbSNP
rs146197428 2329 dbSNP
rs1489085009 2332 dbSNP
rs878974624 2332 dbSNP
rs193051283 2333 dbSNP
rs1207179014 2336 dbSNP
rs1387300780 2345 dbSNP
rs1268945601 2347 dbSNP
rs1232828311 2349 dbSNP
rs950594497 2351 dbSNP
rs1317945574 2352 dbSNP
rs1339545554 2359 dbSNP
rs1219950543 2360 dbSNP
rs550380969 2361 dbSNP
rs1319856801 2367 dbSNP
rs1285041200 2374 dbSNP
rs1390578486 2377 dbSNP
rs1289017069 2398 dbSNP
rs1465230153 2400 dbSNP
rs1357126440 2401 dbSNP
rs573065796 2403 dbSNP
rs776053089 2404 dbSNP
rs1034947225 2409 dbSNP
rs1187249596 2413 dbSNP
rs1232515605 2416 dbSNP
rs1249043844 2418 dbSNP
rs1253718070 2422 dbSNP
rs959168772 2425 dbSNP
rs545368199 2433 dbSNP
rs991063429 2438 dbSNP
rs1258039540 2456 dbSNP
rs915294622 2466 dbSNP
rs1205310791 2468 dbSNP
rs946829922 2474 dbSNP
rs1226088828 2475 dbSNP
rs978099571 2476 dbSNP
rs1487477727 2482 dbSNP
rs565187779 2484 dbSNP
rs1376473968 2492 dbSNP
rs542360914 2497 dbSNP
rs923973313 2514 dbSNP
rs1057067 2515 dbSNP
rs1369412654 2519 dbSNP
rs1433093952 2543 dbSNP
rs1167192441 2575 dbSNP
rs1432166773 2577 dbSNP
rs1197424922 2581 dbSNP
rs544209657 2581 dbSNP
rs58957091 2584 dbSNP
rs769399415 2602 dbSNP
rs1454394879 2603 dbSNP
rs1482730615 2610 dbSNP
rs1272564129 2613 dbSNP
rs942850966 2620 dbSNP
rs201223319 2629 dbSNP
rs1158154983 2632 dbSNP
rs1251854009 2644 dbSNP
rs1243739937 2645 dbSNP
rs143288804 2646 dbSNP
rs529765245 2647 dbSNP
rs1415027292 2653 dbSNP
rs1349570509 2654 dbSNP
rs898909386 2666 dbSNP
rs185410145 2668 dbSNP
rs1397797975 2676 dbSNP
rs1163222412 2679 dbSNP
rs1456669713 2683 dbSNP
rs559568691 2693 dbSNP
rs1370577756 2699 dbSNP
rs995017441 2702 dbSNP
rs1472378343 2705 dbSNP
rs1025970526 2711 dbSNP
rs1184399488 2718 dbSNP
rs886076459 2719 dbSNP
rs189925810 2720 dbSNP
rs1299141807 2724 dbSNP
rs1034896236 2726 dbSNP
rs959283074 2733 dbSNP
rs1336964255 2735 dbSNP
rs1012079450 2742 dbSNP
rs1022572121 2753 dbSNP
rs192993924 2756 dbSNP
rs1239150505 2760 dbSNP
rs1323412328 2761 dbSNP
rs978554427 2763 dbSNP
rs183981493 2767 dbSNP
rs1326968239 2768 dbSNP
rs1457081943 2778 dbSNP
rs756411381 2787 dbSNP
rs1409974975 2792 dbSNP
rs1161673157 2804 dbSNP
rs955337956 2812 dbSNP
rs537318640 2815 dbSNP
rs1196936097 2817 dbSNP
rs550981203 2822 dbSNP
rs1351040007 2823 dbSNP
rs1449783909 2825 dbSNP
rs911468788 2829 dbSNP
rs1214062565 2830 dbSNP
rs1464298308 2831 dbSNP
rs1229870515 2836 dbSNP
rs1350685235 2838 dbSNP
rs528997718 2841 dbSNP
rs1230499440 2844 dbSNP
rs1333301999 2846 dbSNP
rs1292924237 2854 dbSNP
rs1488378626 2856 dbSNP
rs567649776 2857 dbSNP
rs115266085 2858 dbSNP
rs1419680361 2860 dbSNP
rs930171198 2861 dbSNP
rs1047489455 2862 dbSNP
rs1170875130 2864 dbSNP
rs1479073076 2876 dbSNP
rs1396772805 2881 dbSNP
rs1194208444 2887 dbSNP
rs1448588705 2888 dbSNP
rs1374679062 2891 dbSNP
rs1245970204 2905 dbSNP
rs1217765206 2911 dbSNP
rs144390512 2921 dbSNP
rs573326720 2927 dbSNP
rs1277524747 2943 dbSNP
rs117700179 2952 dbSNP
rs763981114 2960 dbSNP
rs1349443798 2961 dbSNP
rs1281595544 2964 dbSNP
rs1446645938 2969 dbSNP
rs1164491374 2971 dbSNP
rs558430680 2973 dbSNP
rs1457234931 2980 dbSNP
rs1340067253 2981 dbSNP
rs1431996424 2981 dbSNP
rs146620297 2991 dbSNP
rs1012606122 2995 dbSNP
rs11552203 2996 dbSNP
rs761790191 3002 dbSNP
rs565650071 3004 dbSNP
rs753936464 3015 dbSNP
rs574094276 3021 dbSNP
rs955491853 3023 dbSNP
rs1315340193 3025 dbSNP
rs1184974013 3032 dbSNP
rs1486326690 3040 dbSNP
rs1321440113 3047 dbSNP
rs1243075700 3053 dbSNP
rs986758685 3053 dbSNP
rs539799306 3062 dbSNP
rs559827028 3090 dbSNP
rs532046823 3094 dbSNP
rs911243806 3098 dbSNP
rs1215487221 3102 dbSNP
rs964312910 3115 dbSNP
rs1481238075 3120 dbSNP
rs974699921 3126 dbSNP
rs1198624290 3127 dbSNP
rs534567047 3129 dbSNP
rs1307486766 3137 dbSNP
rs1408120603 3141 dbSNP
rs1368587779 3145 dbSNP
rs1172473079 3147 dbSNP
rs747791892 3159 dbSNP
rs1184387249 3164 dbSNP
rs1047268296 3165 dbSNP
rs1475974991 3167 dbSNP
rs370052274 3167 dbSNP
rs1180790079 3170 dbSNP
rs765387490 3173 dbSNP
rs1235060006 3186 dbSNP
rs1205851129 3187 dbSNP
rs1422954716 3189 dbSNP
rs1162423392 3190 dbSNP
rs939107299 3194 dbSNP
rs1056130357 3199 dbSNP
rs1287996460 3205 dbSNP
rs1226597402 3211 dbSNP
rs894776131 3220 dbSNP
rs188368866 3224 dbSNP
rs565316604 3225 dbSNP
rs531270883 3227 dbSNP
rs758861756 3231 dbSNP
rs778319201 3238 dbSNP
rs1349282308 3240 dbSNP
rs1321310807 3256 dbSNP
rs1330630787 3258 dbSNP
rs903778787 3261 dbSNP
rs777310950 3263 dbSNP
rs571484616 3267 dbSNP
rs1471294014 3269 dbSNP
rs1377983509 3278 dbSNP
rs112996215 3297 dbSNP
rs550983427 3298 dbSNP
rs1177349666 3299 dbSNP
rs891190042 3309 dbSNP
rs1245533479 3310 dbSNP
rs1215897427 3319 dbSNP
rs1469204685 3320 dbSNP
rs1267676081 3321 dbSNP
rs536984392 3321 dbSNP
rs1298156550 3324 dbSNP
rs1319023624 3334 dbSNP
rs1307779717 3336 dbSNP
rs1218770678 3356 dbSNP
rs1008293455 3358 dbSNP
rs1018371519 3359 dbSNP
rs1442767960 3363 dbSNP
rs114741977 3364 dbSNP
rs974102629 3365 dbSNP
rs1256741342 3371 dbSNP
rs1451176168 3372 dbSNP
rs1027615063 3375 dbSNP
rs951642460 3387 dbSNP
rs1432122604 3391 dbSNP
rs757760997 3393 dbSNP
rs530120353 3405 dbSNP
rs1423620953 3413 dbSNP
rs546974801 3423 dbSNP
rs982945973 3425 dbSNP
rs1454924723 3429 dbSNP
rs928816619 3449 dbSNP
rs1204388930 3456 dbSNP
rs1237040321 3458 dbSNP
rs938845169 3459 dbSNP
rs1261570913 3462 dbSNP
rs1482389558 3463 dbSNP
rs1310540744 3464 dbSNP
rs991886247 3465 dbSNP
rs1263542311 3479 dbSNP
rs1371730583 3485 dbSNP
rs1296585802 3486 dbSNP
rs916336761 3487 dbSNP
rs1363600281 3491 dbSNP
rs1289107090 3492 dbSNP
rs115313265 3498 dbSNP
rs1421397216 3499 dbSNP
rs1254079674 3502 dbSNP
rs1470954207 3502 dbSNP
rs1175047283 3508 dbSNP
rs1435867728 3519 dbSNP
rs1176140006 3520 dbSNP
rs11752 3529 dbSNP
rs1430698277 3532 dbSNP
rs1358120627 3537 dbSNP
rs558743106 3538 dbSNP
rs1043434790 3545 dbSNP
rs903767948 3548 dbSNP
rs1211767109 3565 dbSNP
rs935276188 3567 dbSNP
rs1273880783 3573 dbSNP
rs1290296194 3584 dbSNP
rs568940687 3589 dbSNP
rs1341464942 3613 dbSNP
rs180893818 3617 dbSNP
rs184966694 3621 dbSNP
rs890928781 3622 dbSNP
rs1395083100 3624 dbSNP
rs1353241068 3628 dbSNP
rs1347930168 3644 dbSNP
rs553058315 3648 dbSNP
rs1166687529 3650 dbSNP
rs190747264 3658 dbSNP
rs1374000857 3662 dbSNP
rs1164599102 3663 dbSNP
rs1474343865 3669 dbSNP
rs1310554032 3670 dbSNP
rs779714037 3671 dbSNP
rs1250909048 3673 dbSNP
rs1194007251 3678 dbSNP
rs1261545689 3689 dbSNP
rs1488457320 3694 dbSNP
rs539860177 3715 dbSNP
rs899921204 3722 dbSNP
rs1294777993 3743 dbSNP
rs7958 3744 dbSNP
rs963091685 3750 dbSNP
rs1349353272 3772 dbSNP
rs749740408 3779 dbSNP
rs1393641891 3780 dbSNP
rs1397910366 3786 dbSNP
rs142475145 3789 dbSNP
rs1191740306 3793 dbSNP
rs1396915154 3794 dbSNP
rs951596908 3800 dbSNP
rs1472265588 3803 dbSNP
rs983004767 3806 dbSNP
rs1184142350 3811 dbSNP
rs1412280739 3813 dbSNP
rs1160767597 3815 dbSNP
rs1035965077 3834 dbSNP
rs1418778451 3837 dbSNP
rs545565466 3838 dbSNP
rs768420764 3845 dbSNP
rs960156996 3846 dbSNP
rs565514957 3848 dbSNP
rs573003652 3857 dbSNP
rs1301226071 3866 dbSNP
rs1367900286 3870 dbSNP
rs1397143756 3877 dbSNP
rs1327070730 3881 dbSNP
rs531008257 3893 dbSNP
rs947871004 3894 dbSNP
rs1160341363 3909 dbSNP
rs1454399872 3913 dbSNP
rs979492317 3927 dbSNP
rs1192949004 3930 dbSNP
rs1452270600 3940 dbSNP
rs924999176 3942 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 137886.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065670. RNA binding protein: AGO2. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cgGUCGAUUGUUAUG-UGACGGa 5'
            ||  ||  || || |||||| 
Target 5' --CACAUACAAAAACAACUGCCa 3'
 		1 - 21
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM1065670
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / 4-thiouridine, 3_ML_LG
Location of target site ENST00000399598.2 | 3UTR | CACAUACAAAAACAACUGCCAUUUUUGU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE19783 ER- ER- breast cancer 0.339 1.1e-3 0.328 1.6e-3 79 Click to see details
GSE28260 Renal cortex and medulla 0.671 6.0e-3 0.731 2.3e-3 13 Click to see details
GSE19350 CNS germ cell tumors -0.637 1.3e-2 -0.112 3.6e-1 12 Click to see details
GSE19536 Breast cancer 0.165 5.0e-2 0.243 7.4e-3 100 Click to see details
GSE32688 Pancreatic cancer -0.23 1.0e-1 -0.243 9.0e-2 32 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.241 1.2e-1 -0.338 4.9e-2 25 Click to see details
GSE42095 Differentiated embryonic stem cells -0.192 1.9e-1 -0.344 5.4e-2 23 Click to see details
GSE21849 B cell lymphoma -0.162 2.0e-1 0.379 2.1e-2 29 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.151 2.4e-1 0.105 3.1e-1 25 Click to see details
GSE19783 ER+ ER+ breast cancer -0.155 2.6e-1 -0.068 3.9e-1 20 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.152 2.6e-1 -0.713 2.1e-4 20 Click to see details
GSE21687 Ependynoma primary tumors 0.071 2.9e-1 0.043 3.7e-1 64 Click to see details
GSE28544 Breast cancer 0.114 3.0e-1 0.285 8.9e-2 24 Click to see details
GSE17306 Multiple myeloma -0.02 4.5e-1 0.175 1.1e-1 49 Click to see details
GSE15076 Monocyte-derived dendritic cells -0.014 4.9e-1 0.214 3.1e-1 8 Click to see details
GSE17498 Multiple myeloma -0.001 5.0e-1 0.022 4.5e-1 40 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
THCA 0.924 0.12 0.500 0.33 3 Click to see details
BRCA 0.242 0.38 0.800 0.1 4 Click to see details
LUSC -0.191 0.4 0.200 0.4 4 Click to see details
UCEC 0.034 0.47 -0.262 0.27 8 Click to see details
UCEC 0.034 0.47 -0.262 0.27 8 Click to see details
UCEC 0.034 0.47 -0.262 0.27 8 Click to see details
UCEC 0.034 0.47 -0.262 0.27 8 Click to see details
UCEC 0.034 0.47 -0.262 0.27 8 Click to see details
109 hsa-miR-449b-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT006349 SIRT1 sirtuin 1 2 1
MIRT006350 CCNE2 cyclin E2 4 3
MIRT006351 MET MET proto-oncogene, receptor tyrosine kinase 2 1
MIRT006352 GMNN geminin, DNA replication inhibitor 2 1
MIRT006353 HDAC1 histone deacetylase 1 2 1
MIRT016137 CDK4 cyclin dependent kinase 4 1 1
MIRT016138 CDC25A cell division cycle 25A 2 1
MIRT016139 CDK6 cyclin dependent kinase 6 4 3
MIRT057740 ZDHHC16 zinc finger DHHC-type containing 16 2 2
MIRT078636 FAM104A family with sequence similarity 104 member A 2 2
MIRT100407 HSPA1B heat shock protein family A (Hsp70) member 1B 2 2
MIRT115552 MAZ MYC associated zinc finger protein 2 2
MIRT130146 TXNIP thioredoxin interacting protein 2 4
MIRT142254 DCTN5 dynactin subunit 5 2 2
MIRT143724 CCL22 C-C motif chemokine ligand 22 2 2
MIRT168101 E2F3 E2F transcription factor 3 2 2
MIRT169809 GIGYF1 GRB10 interacting GYF protein 1 2 4
MIRT183694 MDM4 MDM4, p53 regulator 2 2
MIRT198922 SMAD4 SMAD family member 4 2 2
MIRT202950 TSN translin 2 4
MIRT221565 CBX3 chromobox 3 2 2
MIRT253418 EVI5L ecotropic viral integration site 5 like 2 2
MIRT294759 ZNF551 zinc finger protein 551 2 4
MIRT307053 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT331273 TM9SF3 transmembrane 9 superfamily member 3 2 6
MIRT372293 UBXN2B UBX domain protein 2B 2 2
MIRT374317 MBD6 methyl-CpG binding domain protein 6 2 2
MIRT445817 DNAAF3 dynein axonemal assembly factor 3 2 2
MIRT447158 MFSD8 major facilitator superfamily domain containing 8 2 2
MIRT447823 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT448798 GMFB glia maturation factor beta 2 2
MIRT451580 HIRIP3 HIRA interacting protein 3 2 2
MIRT452679 GPR156 G protein-coupled receptor 156 2 2
MIRT453158 CNOT4 CCR4-NOT transcription complex subunit 4 2 6
MIRT453634 SLC4A2 solute carrier family 4 member 2 2 2
MIRT455384 PLA2G2D phospholipase A2 group IID 2 2
MIRT456958 SPAM1 sperm adhesion molecule 1 2 2
MIRT462739 EFNB1 ephrin B1 2 2
MIRT464321 UST uronyl 2-sulfotransferase 2 2
MIRT465641 TNRC18P2 trinucleotide repeat containing 18 pseudogene 2 2 10
MIRT466748 SYNGR2 synaptogyrin 2 2 2
MIRT468345 SF3B3 splicing factor 3b subunit 3 2 2
MIRT469324 RGP1 RGP1 homolog, RAB6A GEF complex partner 1 2 2
MIRT474361 KMT2D lysine methyltransferase 2D 2 2
MIRT475316 IFNLR1 interferon lambda receptor 1 2 2
MIRT477759 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT477824 DYRK3 dual specificity tyrosine phosphorylation regulated kinase 3 2 2
MIRT478265 DDX19B DEAD-box helicase 19B 2 2
MIRT481042 BAZ2A bromodomain adjacent to zinc finger domain 2A 2 2
MIRT481289 ATXN1L ataxin 1 like 2 2
MIRT482730 COPZ1 coatomer protein complex subunit zeta 1 2 2
MIRT488780 CYTH3 cytohesin 3 2 2
MIRT489578 SSBP2 single stranded DNA binding protein 2 2 2
MIRT489659 SHMT1 serine hydroxymethyltransferase 1 2 4
MIRT490527 KIAA1715 lunapark, ER junction formation factor 2 2
MIRT492949 NEUROD2 neuronal differentiation 2 2 2
MIRT493154 MKNK2 MAP kinase interacting serine/threonine kinase 2 2 2
MIRT493845 FOXN3 forkhead box N3 2 4
MIRT494743 ARHGAP1 Rho GTPase activating protein 1 2 6
MIRT496491 MAST3 microtubule associated serine/threonine kinase 3 2 2
MIRT503312 FICD FIC domain containing 2 4
MIRT503507 ZNF623 zinc finger protein 623 2 2
MIRT504182 FAM127B retrotransposon Gag like 8A 2 2
MIRT505010 ZNF644 zinc finger protein 644 2 2
MIRT505352 TMEM167A transmembrane protein 167A 2 2
MIRT505645 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT505710 SESN2 sestrin 2 2 2
MIRT505777 SATB2 SATB homeobox 2 2 6
MIRT506208 PHF19 PHD finger protein 19 2 2
MIRT506251 PEG10 paternally expressed 10 2 2
MIRT507786 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT508005 BCL2L13 BCL2 like 13 2 4
MIRT508857 ZRSR1 zinc finger CCCH-type, RNA binding motif and serine/arginine rich 1 2 4
MIRT510546 XBP1P1 X-box binding protein 1 pseudogene 1 2 4
MIRT511892 GAS1 growth arrest specific 1 2 6
MIRT512907 UBL4A ubiquitin like 4A 2 2
MIRT513600 VPS37B VPS37B, ESCRT-I subunit 2 2
MIRT521241 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT521321 RRAGD Ras related GTP binding D 2 4
MIRT525281 C18orf32 chromosome 18 open reading frame 32 2 2
MIRT528650 RWDD2A RWD domain containing 2A 2 4
MIRT535101 PODXL podocalyxin like 2 2
MIRT547752 KBTBD6 kelch repeat and BTB domain containing 6 2 4
MIRT547865 HSPA13 heat shock protein family A (Hsp70) member 13 2 2
MIRT549170 BMP3 bone morphogenetic protein 3 2 2
MIRT550115 SLC35G2 solute carrier family 35 member G2 2 2
MIRT556097 MOAP1 modulator of apoptosis 1 2 2
MIRT557172 HOXA13 homeobox A13 2 2
MIRT557422 GXYLT2 glucoside xylosyltransferase 2 2 2
MIRT557931 FAM73A mitoguardin 1 2 2
MIRT568804 VPS37D VPS37D, ESCRT-I subunit 2 2
MIRT571326 TPCN2 two pore segment channel 2 2 2
MIRT572598 PAPLN papilin, proteoglycan like sulfated glycoprotein 2 2
MIRT573437 APOPT1 apoptogenic 1, mitochondrial 2 2
MIRT574092 VASN vasorin 2 2
MIRT608688 VAV3 vav guanine nucleotide exchange factor 3 2 4
MIRT608800 ITGA11 integrin subunit alpha 11 2 4
MIRT610332 SSX5 SSX family member 5 2 2
MIRT613158 DDA1 DET1 and DDB1 associated 1 2 2
MIRT625407 CPEB3 cytoplasmic polyadenylation element binding protein 3 2 2
MIRT636603 CLIC5 chloride intracellular channel 5 2 2
MIRT638573 IER5 immediate early response 5 2 2
MIRT639686 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT677979 ITGB3 integrin subunit beta 3 2 2
MIRT685217 POTED POTE ankyrin domain family member D 2 2
MIRT702570 JARID2 jumonji and AT-rich interaction domain containing 2 2 2
MIRT706259 MKLN1 muskelin 1 2 2
MIRT734675 HMGB1 high mobility group box 1 3 0
MIRT736369 HSPA1A heat shock protein family A (Hsp70) member 1A 1 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-449b Glucose NULL 5793 Quantitative real-time PCR endothelial cells 24394957 2014 down-regulated
miR-449b Doxorubicin approved 31703 Quantitative real-time PCR ovarian carcinoma cell line A2780 cells 22340095 2012 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-449b Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-449b Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-449b-5p Gemcitabine 60750 NSC613327 approved sensitive High Pancreatic Cancer cell line (SUIT-2, CAPAN-1)
hsa-miR-449b-5p Oxaliplatin 6857599 NSC266046 approved resistant High Colorectal Cancer cell line (RKO)
hsa-miR-449b-5p Oxaliplatin 6857599 NSC266046 approved sensitive High Colorectal Cancer cell line (HCT-116)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved sensitive High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Panobinostat 6918837 NSC761190 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-449b-5p Cisplatin 5460033 NSC119875 approved resistant High Gastric Cancer tissue
hsa-miR-449b-5p Fluorouracil 3385 NSC19893 approved resistant High Gastric Cancer tissue
hsa-miR-449b-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-449b-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (451Lu)
hsa-miR-449b-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (HeyA8)
hsa-miR-449b-5p Paclitaxel 36314 NSC125973 approved resistant cell line (SKVO3ip1)
hsa-miR-449b-5p Fluorouracil 3385 NSC19893 approved resistant cell line (KM12C) (72 h)
hsa-miR-449b-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-449b-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-449b-5p Ceritinib 57379345 NSC776422 approved sensitive cell line (H3122)
hsa-miR-449b-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide/Methotrexate/Gemcitabine resistant cell line (Bats-72)
hsa-miR-449b-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide resistant cell line (Bads-200)

Error report submission