miRTarBase - #MIRT380416


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pre-miRNA Information
pre-miRNA hsa-mir-136   
Genomic Coordinates chr14: 100884702 - 100884783
Description Homo sapiens miR-136 stem-loop
Comment miR-136 was first identified by cloning studies in mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-136-3p
Sequence 49| CAUCAUCGUCUCAAAUGAGUCU |70
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
C-to-U 12 14 + 100884761 26209130 MiREDiBase
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM7823565 1 COSMIC
COSM3493816 7 COSMIC
COSM1368268 8 COSMIC
COSM7310051 10 COSMIC
COSM1368269 14 COSMIC
COSM1368270 19 COSMIC
COSM344261 20 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs147448304 2 dbSNP
rs371763274 7 dbSNP
rs775059932 8 dbSNP
rs1396077682 16 dbSNP
rs761406043 18 dbSNP
rs767143412 19 dbSNP
rs375044864 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol HNRNPC   
Synonyms C1, C2, HNRNP, HNRPC, SNRPC
Description heterogeneous nuclear ribonucleoprotein C (C1/C2)
Transcript NM_001077442   
Other Transcripts NM_001077443 , NM_004500 , NM_031314   
Expression
Putative miRNA Targets on HNRNPC
3'UTR of HNRNPC
(miRNA target sites are highlighted)		 
>HNRNPC|NM_001077442|3'UTR
   1 GCACATAGTGGGGTTTAGAAATCTTATCCCATTATTTCTTTACCTAGGCGCTTGTCTAAGATCAAATTTTTCACCAGATC
  81 CTCTCCCCTAGTATCTTCAGCACATGCTCACTGTTCTCCCCATCCTTGTCCTTCCCATGTTCATTAATTCATATTGCCCC
 161 GCGCCTAGTCCCATTTTCACTTCCTTTGACGCTCCTAGTAGTTTTGTTAAGTCTTACCCTGTAATTTTTGCTTTTAATTT
 241 TGATACCTCTTTATGACTTAACAATAAAAAGGATGTATGGTTTTTATCAACTGTCTCCAAAATAATCTCTTGTTATGCAG
 321 GGAGTACAGTTCTTTTCATTCATACATAAGTTCAGTAGTTGCTTCCCTAACTGCAAAGGCAATCTCATTTAGTTGAGTAG
 401 CTCTTGAAAGCAGCTTTGAGTTAGAAGTATGTGTGTTACACCCTCACATTAGTGTGCTGTGTGGGGCAGTTCAACACAAA
 481 TGTAACAATGTATTTTTGTGAATGAGAGTTGGCATGTCAAATGCATCCTCTAGAAAAATAATTAGTGTTATAGTCTTAAG
 561 ATTTGTTTTCTAAAGTTGATACTGTGGGTTATTTTTGTGAACAGCCTGATGTTTGGGACCTTTTTTCCTCAAAATAAACA
 641 AGTCCTTATTAAACCAGGAATTTGGAGAAAAAAAAAACCCTGGTTTTTTATTTTTGTATTTTATTATTGTTTACTTCAAA
 721 CTTTGTTTTACAGCGTCCTCCACAAAACCTCTAGAATGCACTAGATATATTTTTCTTGGAGTCATAATCATGATGCATAC
 801 CAACACAACACTACTCAAATTATATTTCATTGAGATGCATGTTGCATTGAGGAGTCAACTTGACATAGAGTGGAGACTTT
 881 TTCAAAATGGCTTTTACATCCTAATGAAAGTTTGGGAAGTATATCCTCTCTGCCTTTTCATCAGTGCTTTGTGGTCCAGC
 961 TGGCACCCTTTCTGAGGTTTGTGTTTTGTGCTAAATGGTTTTGTCCTTAAATAGGAGAGGCTCAAAAACATCAAGATTTC
1041 AGGAAAATGGCGACAGCTGCATAATGGAACCCCCCTGCTTCTATTTTGTTCTTTTAATTACTATTTATAGCCCCAGTTAC
1121 CTTCTGAATTCTGAAGTGTATATACCTCCATGTTCCTGAAAACAAGAAAACTCTTACTTCCTGATATTCCATAGACTGCC
1201 TTCCCAGGTGATTGAGAACATAGAGAATGTTACACATTTATTTTACTCTAAATGATCTTTTACCCCTGTTAGCTAATCTT
1281 TGTGTTTTCCTCAACTTTATTAATTACAGTGATTGCATTTTTAGCATCCAGTTGTAAGATGAATATATTAAACAGCTACC
1361 AGTGTTGGTGATACCTCATCCTTGAAAGGCTTAGTTCATTTGTGTTTTATACTTCAGTTTTTCCAGCATAGCAGAAAATG
1441 CCGCTTATAATTTTTGTGCACACAAACCTTGGATTCCCCTGTAAAGTTGCTATTGTTTCATAGCATGCGGCACTGGCCTT
1521 TTTTCATCCTACTCATTACAGGCAAAACTCATGTCTTATTTATGAGGATTTTATAGATCATTTTCTGTAACAGGTGACAA
1601 AAGCAGAAAAGAATGAAGAGGCTGAAGTATGAACTACCCTTGGAGCCCATATACATGATATAGGCAATTTCTTTTGTATG
1681 TTAATTCAGTCAAAAATACTACCCACTTGATGTTTTCTAATCTGATGTGAGCTCATGTTACACAGACTTTTAGTAAGTAA
1761 CCCGTGACTAGAAAATAAACTGGATGCTTAGGAGAGAGTGTCAGATGTATAAGATGCTAATAAAACCTGTTTAATATTAT
1841 TGTTAGCTGTAAGTTTTTGGGAAATACTGAACAAATTAGTCCACAATCAAGTGTCTACTTTTCCCTTCACTGTAGGGCCT
1921 CTCCCTGCACAGAGCAGTCTGTTTAGCTGTGAACACCACAATCTGCAGATGTTCAAGTCCCTTACATAAAATGGCATAGT
2001 ATTTATATGTAACCTATGCATATTCTCCTGTATATTTTAAATCATCTCTACATTAAAATACCTGATAAAATGTAAATGGT
2081 ATGTAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucuGAGUAAACUCUGCUACUAc 5'
             ||:||||   |:|| ||| 
Target 5' tgtCTTATTT---ATGAGGATt 3'
 1552 - 1570 116.00 -7.80
2 
miRNA  3' ucugaguaaaCUCUGCUACUAc 5'
                    | | :|:|||| 
Target 5' acagctaccaGTGTTGGTGATa 3'
 1352 - 1373 112.00 -7.20
3 
miRNA  3' ucUGAGUAAACUCUGCUACUac 5'
            |: || |||  | |||||  
Target 5' gcATCCAGTTG-TAAGATGAat 3'
 1324 - 1344 107.00 -5.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN32058353 24 COSMIC
COSN30479749 32 COSMIC
COSN31525493 38 COSMIC
COSN30120559 69 COSMIC
COSN31493409 75 COSMIC
COSN20078025 116 COSMIC
COSN30527131 134 COSMIC
COSN30193153 136 COSMIC
COSN31529093 150 COSMIC
COSN31598702 157 COSMIC
COSN30175740 161 COSMIC
COSN31521727 198 COSMIC
COSN31520023 268 COSMIC
COSN24027541 271 COSMIC
COSN31483513 322 COSMIC
COSN18881124 355 COSMIC
COSN31578489 427 COSMIC
COSN30163759 551 COSMIC
COSN19712787 553 COSMIC
COSN31582825 658 COSMIC
COSN26668079 664 COSMIC
COSN26668663 665 COSMIC
COSN17182249 751 COSMIC
COSN17182247 789 COSMIC
COSN7431323 994 COSMIC
COSN32144747 1173 COSMIC
COSN17182246 1397 COSMIC
COSN29215218 1745 COSMIC
COSN17182245 1881 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs770485693 5 dbSNP
rs202220066 8 dbSNP
rs372633026 12 dbSNP
rs1198484561 13 dbSNP
rs367658866 16 dbSNP
rs189303190 17 dbSNP
rs536889167 20 dbSNP
rs751836295 23 dbSNP
rs779644468 27 dbSNP
rs758199222 28 dbSNP
rs750276379 31 dbSNP
rs375762571 34 dbSNP
rs1227254851 44 dbSNP
rs765154159 47 dbSNP
rs761777866 48 dbSNP
rs753263998 49 dbSNP
rs763684458 50 dbSNP
rs534742193 53 dbSNP
rs1308492250 54 dbSNP
rs1414109533 56 dbSNP
rs1477044703 57 dbSNP
rs1373047261 60 dbSNP
rs888288761 63 dbSNP
rs1175011191 67 dbSNP
rs1044129524 71 dbSNP
rs1012711895 77 dbSNP
rs895477308 80 dbSNP
rs1057224059 84 dbSNP
rs1158815901 88 dbSNP
rs1417774090 91 dbSNP
rs1253106757 92 dbSNP
rs1322389210 93 dbSNP
rs1064971 95 dbSNP
rs1328859146 97 dbSNP
rs112267670 107 dbSNP
rs566039910 108 dbSNP
rs1183457243 109 dbSNP
rs11669 113 dbSNP
rs28559592 116 dbSNP
rs1270266254 117 dbSNP
rs549317790 118 dbSNP
rs1218537816 121 dbSNP
rs934360719 124 dbSNP
rs878942121 125 dbSNP
rs1483695097 129 dbSNP
rs535711889 138 dbSNP
rs1237163638 139 dbSNP
rs1318448312 141 dbSNP
rs1288774135 143 dbSNP
rs1214561504 147 dbSNP
rs1232563411 153 dbSNP
rs1380246252 153 dbSNP
rs113941786 156 dbSNP
rs1477485127 157 dbSNP
rs1314157347 158 dbSNP
rs1042652307 159 dbSNP
rs1383784228 160 dbSNP
rs1475378433 161 dbSNP
rs867503129 162 dbSNP
rs1455035901 163 dbSNP
rs915449438 164 dbSNP
rs371131630 168 dbSNP
rs1160407256 170 dbSNP
rs922611153 180 dbSNP
rs1416398989 184 dbSNP
rs919572426 185 dbSNP
rs1399966807 187 dbSNP
rs569870789 188 dbSNP
rs1443013156 189 dbSNP
rs796315888 190 dbSNP
rs977135287 195 dbSNP
rs1203565370 197 dbSNP
rs961414888 198 dbSNP
rs796121793 199 dbSNP
rs1212892992 204 dbSNP
rs14865 206 dbSNP
rs533144936 208 dbSNP
rs1285077774 209 dbSNP
rs1245433689 210 dbSNP
rs1325293704 217 dbSNP
rs1487963426 217 dbSNP
rs570490265 219 dbSNP
rs796618010 222 dbSNP
rs1388969967 227 dbSNP
rs1321614980 230 dbSNP
rs199683587 241 dbSNP
rs1186624841 246 dbSNP
rs1392747618 247 dbSNP
rs201687342 250 dbSNP
rs1366476506 252 dbSNP
rs1470971281 258 dbSNP
rs1473427427 262 dbSNP
rs200418652 264 dbSNP
rs1417258866 265 dbSNP
rs1191171372 269 dbSNP
rs1314165461 273 dbSNP
rs1451534766 280 dbSNP
rs1064879 285 dbSNP
rs3208564 287 dbSNP
rs3203452 288 dbSNP
rs1248945495 290 dbSNP
rs1377869881 303 dbSNP
rs575929065 312 dbSNP
rs1397092927 314 dbSNP
rs1333983533 316 dbSNP
rs373650545 324 dbSNP
rs547446756 327 dbSNP
rs1339029037 329 dbSNP
rs527310949 333 dbSNP
rs1005478089 335 dbSNP
rs1310183447 338 dbSNP
rs952523321 340 dbSNP
rs370953463 341 dbSNP
rs1238144128 343 dbSNP
rs1282524566 344 dbSNP
rs1485985883 352 dbSNP
rs377326643 355 dbSNP
rs1249077208 357 dbSNP
rs1229034347 362 dbSNP
rs1253853699 370 dbSNP
rs1022840697 373 dbSNP
rs1302157451 382 dbSNP
rs1182098901 386 dbSNP
rs1481005495 387 dbSNP
rs368387560 390 dbSNP
rs1237253785 392 dbSNP
rs1437430749 395 dbSNP
rs760177903 398 dbSNP
rs1369178491 404 dbSNP
rs1012651060 411 dbSNP
rs1172468710 416 dbSNP
rs376022710 417 dbSNP
rs1406430327 423 dbSNP
rs895530155 429 dbSNP
rs1332451334 432 dbSNP
rs561691728 438 dbSNP
rs1444807975 439 dbSNP
rs534340320 440 dbSNP
rs1312806887 442 dbSNP
rs1035455699 459 dbSNP
rs11559122 461 dbSNP
rs371373033 477 dbSNP
rs376992152 482 dbSNP
rs998890552 488 dbSNP
rs1196230426 493 dbSNP
rs542923894 501 dbSNP
rs1248195475 509 dbSNP
rs902851167 522 dbSNP
rs1253121988 527 dbSNP
rs1199352265 532 dbSNP
rs1437136904 538 dbSNP
rs1196110765 542 dbSNP
rs1376499078 543 dbSNP
rs1248400942 544 dbSNP
rs1197491134 546 dbSNP
rs1042616574 551 dbSNP
rs947003818 552 dbSNP
rs796443872 553 dbSNP
rs1464290752 558 dbSNP
rs796127568 560 dbSNP
rs374204045 563 dbSNP
rs1349650883 575 dbSNP
rs1276952251 582 dbSNP
rs1437704857 586 dbSNP
rs183757816 592 dbSNP
rs1299279777 604 dbSNP
rs1328171917 605 dbSNP
rs1327357745 606 dbSNP
rs199533911 606 dbSNP
rs201584649 607 dbSNP
rs200290202 608 dbSNP
rs1412236755 609 dbSNP
rs1219147394 618 dbSNP
rs1257217507 623 dbSNP
rs1315795624 632 dbSNP
rs1215185645 635 dbSNP
rs1371188351 638 dbSNP
rs1487949844 639 dbSNP
rs1299954195 640 dbSNP
rs932840368 642 dbSNP
rs1263189750 648 dbSNP
rs543648404 657 dbSNP
rs1433054813 659 dbSNP
rs150756293 664 dbSNP
rs143591494 665 dbSNP
rs1172930529 666 dbSNP
rs1469496846 667 dbSNP
rs192348593 668 dbSNP
rs1184197634 669 dbSNP
rs1483361685 676 dbSNP
rs557994808 677 dbSNP
rs1167534302 678 dbSNP
rs1291912730 678 dbSNP
rs1477013132 678 dbSNP
rs541484640 678 dbSNP
rs939979097 678 dbSNP
rs1387172669 679 dbSNP
rs984032370 680 dbSNP
rs1208167981 682 dbSNP
rs1443775885 683 dbSNP
rs952637806 689 dbSNP
rs1242098180 690 dbSNP
rs1320794553 690 dbSNP
rs1222852557 691 dbSNP
rs1262007090 696 dbSNP
rs1488293123 696 dbSNP
rs1350337764 703 dbSNP
rs1022904699 706 dbSNP
rs746631170 719 dbSNP
rs991290430 729 dbSNP
rs370214305 734 dbSNP
rs555756766 735 dbSNP
rs1414951510 739 dbSNP
rs998654107 740 dbSNP
rs535848957 743 dbSNP
rs1312327678 746 dbSNP
rs1162900324 747 dbSNP
rs570008614 754 dbSNP
rs1365614023 761 dbSNP
rs1420327145 775 dbSNP
rs902839069 781 dbSNP
rs556485356 784 dbSNP
rs1416518155 790 dbSNP
rs1413073382 796 dbSNP
rs573210629 797 dbSNP
rs1378120314 798 dbSNP
rs1021273147 800 dbSNP
rs1335036019 803 dbSNP
rs1400367238 808 dbSNP
rs1405472724 812 dbSNP
rs1161151062 814 dbSNP
rs1011096407 822 dbSNP
rs1238880369 836 dbSNP
rs539287142 837 dbSNP
rs570597965 838 dbSNP
rs894038912 848 dbSNP
rs1049980050 858 dbSNP
rs932778924 859 dbSNP
rs1238447165 860 dbSNP
rs1483092707 862 dbSNP
rs901346825 862 dbSNP
rs375617753 871 dbSNP
rs1237561302 883 dbSNP
rs1214568995 888 dbSNP
rs1444952572 889 dbSNP
rs1266587278 897 dbSNP
rs1440516512 898 dbSNP
rs1041526976 901 dbSNP
rs1330411717 903 dbSNP
rs1378497002 910 dbSNP
rs146182488 913 dbSNP
rs1436513741 915 dbSNP
rs1176654001 916 dbSNP
rs1358386199 918 dbSNP
rs1445606945 919 dbSNP
rs1299638648 922 dbSNP
rs940155828 924 dbSNP
rs187678340 925 dbSNP
rs984097612 929 dbSNP
rs931313556 931 dbSNP
rs1221461572 932 dbSNP
rs915795916 932 dbSNP
rs1381368421 933 dbSNP
rs1284889601 942 dbSNP
rs1260386867 950 dbSNP
rs991404920 958 dbSNP
rs1430241294 960 dbSNP
rs1343709524 961 dbSNP
rs17113516 966 dbSNP
rs1479022045 985 dbSNP
rs547826872 986 dbSNP
rs1424423156 988 dbSNP
rs141881012 995 dbSNP
rs749551161 996 dbSNP
rs1393467177 999 dbSNP
rs1162629141 1005 dbSNP
rs1464781389 1012 dbSNP
rs977560839 1018 dbSNP
rs967176326 1019 dbSNP
rs1413829397 1020 dbSNP
rs1436629302 1021 dbSNP
rs780387291 1025 dbSNP
rs1185467827 1028 dbSNP
rs1273732779 1030 dbSNP
rs1367594481 1031 dbSNP
rs1217922300 1038 dbSNP
rs1280497986 1042 dbSNP
rs1021349805 1046 dbSNP
rs1011169777 1048 dbSNP
rs184863444 1051 dbSNP
rs1222488663 1052 dbSNP
rs953057928 1053 dbSNP
rs1190901576 1054 dbSNP
rs1028493383 1058 dbSNP
rs1465574692 1064 dbSNP
rs1424107487 1065 dbSNP
rs1168239980 1066 dbSNP
rs997149114 1068 dbSNP
rs1405584456 1074 dbSNP
rs1322325907 1075 dbSNP
rs1300534959 1076 dbSNP
rs546755497 1076 dbSNP
rs901332469 1076 dbSNP
rs1341659244 1077 dbSNP
rs1218454170 1088 dbSNP
rs1276693778 1094 dbSNP
rs1358808830 1097 dbSNP
rs1004688135 1103 dbSNP
rs1289246047 1107 dbSNP
rs887160074 1112 dbSNP
rs1218730930 1113 dbSNP
rs1048516610 1115 dbSNP
rs867110221 1116 dbSNP
rs543686917 1120 dbSNP
rs1472926226 1124 dbSNP
rs1162241610 1136 dbSNP
rs915951257 1140 dbSNP
rs1421044605 1142 dbSNP
rs1298241987 1145 dbSNP
rs1290656219 1146 dbSNP
rs1214122631 1155 dbSNP
rs1056109425 1165 dbSNP
rs1342566290 1167 dbSNP
rs1283765717 1169 dbSNP
rs1449069277 1169 dbSNP
rs1354477738 1171 dbSNP
rs1300015666 1174 dbSNP
rs1242452269 1177 dbSNP
rs1436108295 1177 dbSNP
rs1369907274 1179 dbSNP
rs1352921100 1180 dbSNP
rs192844483 1187 dbSNP
rs1323677043 1191 dbSNP
rs1442741570 1194 dbSNP
rs1186554001 1200 dbSNP
rs748164909 1214 dbSNP
rs1235423994 1218 dbSNP
rs1438480513 1221 dbSNP
rs564665271 1225 dbSNP
rs1350446152 1228 dbSNP
rs938641013 1236 dbSNP
rs1419629504 1239 dbSNP
rs1157297735 1252 dbSNP
rs1407781019 1255 dbSNP
rs1415449001 1260 dbSNP
rs541174838 1266 dbSNP
rs534668099 1268 dbSNP
rs1453454740 1272 dbSNP
rs1376205009 1284 dbSNP
rs1236822920 1286 dbSNP
rs1252729343 1292 dbSNP
rs188508021 1300 dbSNP
rs1345594383 1312 dbSNP
rs138750879 1313 dbSNP
rs542280726 1314 dbSNP
rs1199731011 1315 dbSNP
rs1189891937 1323 dbSNP
rs914289901 1325 dbSNP
rs576486243 1328 dbSNP
rs989860797 1334 dbSNP
rs746263811 1339 dbSNP
rs1237063707 1345 dbSNP
rs1028652201 1346 dbSNP
rs1200339535 1352 dbSNP
rs556520105 1353 dbSNP
rs144794194 1355 dbSNP
rs1172414943 1361 dbSNP
rs1404286921 1369 dbSNP
rs965683275 1375 dbSNP
rs1332241781 1381 dbSNP
rs1020297371 1384 dbSNP
rs142531772 1385 dbSNP
rs1347475730 1394 dbSNP
rs1232370547 1397 dbSNP
rs751731674 1401 dbSNP
rs1281144059 1409 dbSNP
rs571373271 1409 dbSNP
rs894466943 1411 dbSNP
rs995624254 1411 dbSNP
rs1211181349 1413 dbSNP
rs1368208540 1415 dbSNP
rs1267417765 1417 dbSNP
rs1434263179 1417 dbSNP
rs182952052 1422 dbSNP
rs1427669314 1425 dbSNP
rs1479037345 1426 dbSNP
rs1171795284 1429 dbSNP
rs1423267310 1441 dbSNP
rs868159654 1442 dbSNP
rs928542743 1443 dbSNP
rs757783880 1446 dbSNP
rs1391455832 1448 dbSNP
rs552792942 1456 dbSNP
rs1301161398 1459 dbSNP
rs1342268267 1460 dbSNP
rs1371827128 1467 dbSNP
rs533743233 1468 dbSNP
rs945844167 1471 dbSNP
rs1246453724 1472 dbSNP
rs1433692368 1477 dbSNP
rs914445609 1480 dbSNP
rs751949611 1481 dbSNP
rs1219596859 1489 dbSNP
rs989853912 1490 dbSNP
rs764540912 1492 dbSNP
rs1174397537 1496 dbSNP
rs1435211930 1508 dbSNP
rs1262849121 1512 dbSNP
rs1426964978 1518 dbSNP
rs1426332930 1519 dbSNP
rs921579245 1522 dbSNP
rs975752787 1523 dbSNP
rs966107442 1524 dbSNP
rs567854373 1525 dbSNP
rs983476355 1534 dbSNP
rs1254026735 1536 dbSNP
rs547865027 1553 dbSNP
rs1027184616 1556 dbSNP
rs995571857 1559 dbSNP
rs1313052988 1562 dbSNP
rs1320713985 1564 dbSNP
rs1254554972 1573 dbSNP
rs1243228223 1574 dbSNP
rs1287526302 1576 dbSNP
rs537476768 1588 dbSNP
rs1217904883 1594 dbSNP
rs1235702174 1594 dbSNP
rs749817049 1603 dbSNP
rs1241925190 1605 dbSNP
rs894539235 1606 dbSNP
rs1034861763 1607 dbSNP
rs1257172869 1618 dbSNP
rs1444227776 1619 dbSNP
rs1181882822 1624 dbSNP
rs1382182671 1645 dbSNP
rs1420232061 1648 dbSNP
rs1157928344 1653 dbSNP
rs1002843375 1655 dbSNP
rs1467430494 1660 dbSNP
rs763185883 1661 dbSNP
rs1378069631 1663 dbSNP
rs1449941858 1671 dbSNP
rs1288415659 1675 dbSNP
rs1041633237 1676 dbSNP
rs1376943783 1683 dbSNP
rs1241533594 1687 dbSNP
rs7495 1688 dbSNP
rs766066804 1692 dbSNP
rs1315621736 1693 dbSNP
rs1256939104 1699 dbSNP
rs1461045655 1701 dbSNP
rs1201928641 1702 dbSNP
rs1304165401 1703 dbSNP
rs1240130978 1704 dbSNP
rs192692515 1706 dbSNP
rs1466254077 1715 dbSNP
rs1176664720 1724 dbSNP
rs760308466 1726 dbSNP
rs1405790585 1729 dbSNP
rs550220626 1735 dbSNP
rs1358296078 1736 dbSNP
rs1360068282 1747 dbSNP
rs533632183 1750 dbSNP
rs1445454025 1751 dbSNP
rs1304190678 1752 dbSNP
rs1277260391 1755 dbSNP
rs931836631 1763 dbSNP
rs921666223 1764 dbSNP
rs1323221170 1766 dbSNP
rs1414905596 1770 dbSNP
rs1182982658 1782 dbSNP
rs187862617 1794 dbSNP
rs148114108 1795 dbSNP
rs537727115 1795 dbSNP
rs1008435088 1797 dbSNP
rs1203991315 1799 dbSNP
rs891281514 1800 dbSNP
rs1254182170 1803 dbSNP
rs1191664845 1804 dbSNP
rs772776822 1805 dbSNP
rs1479361235 1809 dbSNP
rs1172510088 1813 dbSNP
rs983018186 1829 dbSNP
rs935565636 1832 dbSNP
rs1408996773 1842 dbSNP
rs1326291726 1846 dbSNP
rs904082471 1849 dbSNP
rs1294684350 1853 dbSNP
rs1222140993 1854 dbSNP
rs1280480071 1861 dbSNP
rs1318893179 1864 dbSNP
rs1027256887 1869 dbSNP
rs563947863 1873 dbSNP
rs762319560 1874 dbSNP
rs1271011565 1880 dbSNP
rs527873941 1886 dbSNP
rs958870090 1890 dbSNP
rs1043426715 1891 dbSNP
rs947666626 1892 dbSNP
rs1195649075 1897 dbSNP
rs1263556628 1900 dbSNP
rs1331129850 1903 dbSNP
rs1474877458 1903 dbSNP
rs1165750473 1906 dbSNP
rs574971643 1909 dbSNP
rs1288838775 1915 dbSNP
rs1003409479 1916 dbSNP
rs1365574463 1917 dbSNP
rs1403580766 1921 dbSNP
rs1300439601 1923 dbSNP
rs916334172 1929 dbSNP
rs1341477180 1932 dbSNP
rs548633170 1936 dbSNP
rs1056612608 1937 dbSNP
rs1338143985 1941 dbSNP
rs562195291 1942 dbSNP
rs907687987 1944 dbSNP
rs1268690949 1945 dbSNP
rs771417058 1947 dbSNP
rs952073149 1948 dbSNP
rs1020735447 1949 dbSNP
rs1291116226 1954 dbSNP
rs1357208028 1956 dbSNP
rs542317732 1965 dbSNP
rs1286510372 1971 dbSNP
rs1190723147 1974 dbSNP
rs1446160503 1974 dbSNP
rs1472917015 1975 dbSNP
rs920478798 1976 dbSNP
rs1382783076 1985 dbSNP
rs974048290 1986 dbSNP
rs1391292053 1989 dbSNP
rs1160481088 1990 dbSNP
rs1423330429 1991 dbSNP
rs1160924454 1993 dbSNP
rs1386287269 1995 dbSNP
rs548568914 1999 dbSNP
rs1316673147 2009 dbSNP
rs1342547071 2013 dbSNP
rs576524275 2016 dbSNP
rs893033460 2018 dbSNP
rs1314466647 2022 dbSNP
rs562833606 2025 dbSNP
rs1054315013 2027 dbSNP
rs1309945001 2030 dbSNP
rs1349869213 2039 dbSNP
rs1203226242 2041 dbSNP
rs1366752193 2043 dbSNP
rs1189768129 2046 dbSNP
rs1202597965 2047 dbSNP
rs931774609 2048 dbSNP
rs761823491 2051 dbSNP
rs1178683295 2058 dbSNP
rs1364945913 2061 dbSNP
rs183248282 2072 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.763 1.2e-3 0.835 1.9e-4 13 Click to see details
GSE28544 Breast cancer 0.542 3.1e-3 0.506 5.8e-3 24 Click to see details
GSE19536 Breast cancer -0.235 9.3e-3 -0.163 5.3e-2 100 Click to see details
GSE19350 CNS germ cell tumors -0.587 2.2e-2 -0.531 3.8e-2 12 Click to see details
GSE19783 ER- ER- breast cancer -0.152 9.1e-2 -0.089 2.2e-1 79 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.311 9.1e-2 0.206 1.9e-1 20 Click to see details
GSE38226 Liver fibrosis 0.257 1.3e-1 0.306 8.9e-2 21 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.228 1.4e-1 0.353 4.2e-2 25 Click to see details
GSE42095 Differentiated embryonic stem cells -0.232 1.4e-1 -0.499 7.7e-3 23 Click to see details
GSE19783 ER+ ER+ breast cancer -0.221 1.7e-1 -0.099 3.4e-1 20 Click to see details
GSE32688 Pancreatic cancer -0.165 1.8e-1 -0.170 1.8e-1 32 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.322 3.0e-1 0.000 5.0e-1 5 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.106 3.1e-1 0.026 4.5e-1 25 Click to see details
GSE21032 Prostate cancer -0.033 3.8e-1 -0.029 4.0e-1 83 Click to see details
GSE21687 Ependynoma primary tumors 0.03 4.1e-1 0.045 3.6e-1 64 Click to see details
GSE17498 Multiple myeloma 0.016 4.6e-1 0.001 5.0e-1 40 Click to see details
GSE26953 Aortic valvular endothelial cells 0.017 4.7e-1 -0.069 3.7e-1 24 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BRCA 0.302 0 0.272 0.01 83 Click to see details
HNSC -0.389 0.01 -0.329 0.02 42 Click to see details
UCEC -0.537 0.01 -0.503 0.02 18 Click to see details
LIHC 0.3 0.02 0.244 0.05 49 Click to see details
KIRP -0.276 0.07 -0.262 0.08 30 Click to see details
KIRC -0.158 0.12 -0.129 0.17 56 Click to see details
STAD 0.207 0.13 0.239 0.09 32 Click to see details
LUSC 0.169 0.16 -0.007 0.48 38 Click to see details
KICH -0.208 0.16 -0.247 0.12 24 Click to see details
BLCA 0.227 0.18 0.259 0.15 18 Click to see details
PAAD 0.58 0.21 0.200 0.4 4 Click to see details
LUAD -0.205 0.26 -0.231 0.24 12 Click to see details
CESC -0.635 0.28 -0.500 0.33 3 Click to see details
THCA 0.077 0.29 0.058 0.34 56 Click to see details
PCPG 0.516 0.33 0.500 0.33 3 Click to see details
CHOL -0.142 0.36 -0.083 0.42 9 Click to see details
PRAD -0.049 0.37 -0.133 0.18 50 Click to see details
ESCA -0.019 0.48 -0.364 0.14 11 Click to see details
ESCA -0.019 0.48 -0.364 0.14 11 Click to see details
ESCA -0.019 0.48 -0.364 0.14 11 Click to see details
ESCA -0.019 0.48 -0.364 0.14 11 Click to see details
46 hsa-miR-136-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT256787 CANX calnexin 1 1
MIRT380416 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 1 1
MIRT439175 ZRANB1 zinc finger RANBP2-type containing 1 1 1
MIRT439356 UBE3C ubiquitin protein ligase E3C 1 1
MIRT439465 TGFBR3 transforming growth factor beta receptor 3 1 1
MIRT440529 GTF2F1 general transcription factor IIF subunit 1 1 1
MIRT440635 FMN1 formin 1 1 1
MIRT440907 COPS4 COP9 signalosome subunit 4 1 1
MIRT441019 CAND1 cullin associated and neddylation dissociated 1 1 1
MIRT441061 C1orf43 chromosome 1 open reading frame 43 1 1
MIRT441174 ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 1 1
MIRT456146 RWDD2A RWD domain containing 2A 2 16
MIRT483517 PRPF38B pre-mRNA processing factor 38B 2 6
MIRT483556 STX11 syntaxin 11 2 4
MIRT495179 SOX11 SRY-box 11 2 6
MIRT495184 MUC20 mucin 20, cell surface associated 2 2
MIRT499361 MYLK myosin light chain kinase 2 8
MIRT504160 OPN5 opsin 5 2 4
MIRT523975 DVL3 dishevelled segment polarity protein 3 2 2
MIRT524343 CREBRF CREB3 regulatory factor 2 8
MIRT526865 PARP11 poly(ADP-ribose) polymerase family member 11 2 2
MIRT531887 SCN1B sodium voltage-gated channel beta subunit 1 2 2
MIRT533351 UHMK1 U2AF homology motif kinase 1 2 2
MIRT534099 SOX5 SRY-box 5 2 4
MIRT557097 HOXA9 homeobox A9 2 2
MIRT567000 KLHL28 kelch like family member 28 2 2
MIRT568215 C1orf21 chromosome 1 open reading frame 21 2 2
MIRT574254 G6PC glucose-6-phosphatase catalytic subunit 2 2
MIRT614013 PAOX polyamine oxidase 2 2
MIRT615541 PHF1 PHD finger protein 1 2 2
MIRT622485 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT623683 HOXB6 homeobox B6 2 2
MIRT630575 PLXDC2 plexin domain containing 2 2 4
MIRT642865 FAM227A family with sequence similarity 227 member A 2 2
MIRT649932 TTLL7 tubulin tyrosine ligase like 7 2 2
MIRT654531 RAB3GAP2 RAB3 GTPase activating non-catalytic protein subunit 2 2 2
MIRT656989 KDM5A lysine demethylase 5A 2 2
MIRT668527 ERP44 endoplasmic reticulum protein 44 2 2
MIRT693411 NUDT16 nudix hydrolase 16 2 2
MIRT700692 POLR3D RNA polymerase III subunit D 2 2
MIRT712284 PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2 2
MIRT717286 TRAF1 TNF receptor associated factor 1 2 2
MIRT724396 IQGAP1 IQ motif containing GTPase activating protein 1 2 2
MIRT725201 PTRF caveolae associated protein 1 2 2
MIRT731933 NOTCH3 notch 3 2 1
MIRT756476 BMPR1B bone morphogenetic protein receptor type 1B 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-136 Lithium (Li) approved 3028194 Microarray rat hippocampus 18704095 2009 up-regulated
miR-136 Valproate approved 3121 Microarray rat hippocampus 18704095 2009 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-136-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer tissue
hsa-miR-136-3p Imatinib 5291 NSC743414 approved sensitive Low Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-136-3p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-136-3p Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-136-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-136-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-136-3p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-136-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (RPMI2650)
hsa-miR-136-3p Sunitinib 5329102 NSC750690 approved sensitive tissue (CardB)
hsa-miR-136-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (K562)
hsa-miR-136-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-136-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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