miRTarBase - #MIRT389635


—
pre-miRNA Information
pre-miRNA hsa-mir-655   
Genomic Coordinates chr14: 101049550 - 101049646
Synonyms MIRN655, hsa-mir-655, MIR655
Description Homo sapiens miR-655 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-655-5p
Sequence 23| AGAGGUUAUCCGUGUUAUGUUC |44
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs766575622 4 dbSNP
rs754023562 5 dbSNP
rs757713353 10 dbSNP
rs369862924 11 dbSNP
rs552601004 12 dbSNP
rs753191773 14 dbSNP
rs569206109 15 dbSNP
rs373094888 18 dbSNP
rs778280798 22 dbSNP
Putative Targets

Gene Information
Gene Symbol LRRC58   
Synonyms -
Description leucine rich repeat containing 58
Transcript NM_001099678   
Expression
Putative miRNA Targets on LRRC58
3'UTR of LRRC58
(miRNA target sites are highlighted)		 
>LRRC58|NM_001099678|3'UTR
   1 ACAGGAGTGCACAGTGTTGTGAAATACTTAAAAAACTGAGCAAAATGGTTAGACAAGAAAATAGAGCTTGAAGTTCACTA
  81 GAAATCTTATCTTCATCTTAAGTGTTCATCAAAGAGTCTGGGATGATATAAAACATTTTGTGTTTCATCTACCCATTCAG
 161 CAAGAATGAGTCCAGTCCCATGTTTAGATTATTTTAACATAATTTGTGAATGATAGTTTCACATTTGGCTGATGGTTTGC
 241 AGTTTTCACTCAAGTTTTGCATGAATCACAAAGCAGAATGGTACCTTTTGAAGAGCAGTTCTGCAATAAGTCATGAGTAG
 321 TATAACTTTTGGACATTGAGATGGAGAAAGTGAGAAATTATCAAAGCTATAATTGCCAGAGTTGCCCTTGGGTTTAGGTA
 401 GAACACTGTATACCATATATACTATATACCATATATACTATATATACCATATATATTATATGCCATAAACAGGATTAACC
 481 CTCCCTTTTCTAATTGCCTGTATGTCTAGATTACAGAACTATTCAAAGAAGCTCACAGATGGTTACATGGGACAAACCTT
 561 TCTGACAAACTAACTGGTAAAGTAAGGCATATAACATTTACATGAGATATTAAAACTTTTTCATTATTATCCTTTGTTCT
 641 ATATGATTGCTATTAACCTTATGTAATCTAGCAATGACTGTTATAGTGCCTTAATCCAGCAAGGATATAAAAATGTATTC
 721 AAGAAGTAATGCCAGAGCAACCTATAACCTGACATACCATGCAGAACATTGTAAAATATTCTTTAACAGAACTAGGTAAA
 801 TAACTGTGTATCTAATATCCGATCTCATGGCCCTCTTAACATTTTTTTGTTTAAATGTGCACTCATCCCTTATAAGCACA
 881 TTACTTTTACACTTAATGGTAGGCCACAATCTTCATCAATCTGTTCATCATAAGACAGAGTAAGAATTTTTAACAGAAAA
 961 TTCTAAAAGAGATAGAAGCTAGGAAAGCTTCTTTATATCTTGCATTAAATGGGTAGGGAAAAAATATGACTCTCACCCAT
1041 GTCATGTACTGGACCATCTTTCTCTACTTTTTAAAGAAAAACTAATACAACTAGAAAAACATCACAACAAGCCAAATAAA
1121 AATGGAGAAAAGGAGTCATTGTCCTTATACCTAATGGAACAGTTTCCAGAACTACTTTAACTATGGAAGCATTTTTGAAA
1201 ATAAAGTATTAATAAAATAGAAAAAAATTATTAAATATATTGTATCCTTAATGTATAGCAGGAAAATAGTTTCACAAATT
1281 AATTGCTATTAGAAATTACCAAATTTTTATTAAGTACTTTAATATGCAATACAAATTGAATAATAGTACAACTATAAGTT
1361 GATATAAAGTAAGTGCTTACTGGTAATCATTAAATAACTAATAACATGACTTGTTGGTTAATGTTAAACCTACAGTAAGA
1441 AATGTTATACAGATCAGATAGGCATTAGAACATCAGGTGTACCTTTTCTGATTTCTGGCATTCATGGCACACCATTTCTT
1521 AAAAGCAGATTGTTGTATAATAACATATACATGTATTAGGGTTTTTTTCATATATATTTTTTATTTTAGAAGAAACTAGC
1601 ATAATTCAGGGTTTATGTGTTTATTTGTATATTAATTCATGAAACATGAGAGTTTCATGAACTGCAGATGTGAAACGCTG
1681 CTATAGAATGAATCCCTTCACCTTTACCTTGTTATAATGTAGTAAGATTTTGTTTTCCTTTTGACTCAGAAATTTTCTAT
1761 GTCTATAGAGGTAATCTAATATGTTCCTACTGCCTAGAAGAGTAATACATAGGTGATTATATCATAAAATAGAGGTATAA
1841 AGTCTTTGCTTACTTCTCCATGTGGGCCACAGCAAGCTGCAGACTGTACAGTTATGAAAGGTAAAGATGACTTAGGCTGT
1921 GCCTAAGTGACAAATGTAAAATGTTTTGTAAATAAGTGACTTACCTAAGATACATAAGATATTTTCATAGAAAATAATGT
2001 ATTCATAGTAAAATACTCAAATTGATAGGACCAATTTTTTCTGGCCTAAATGCTTATGCCTACTTCCTAATCAATTACCA
2081 GCTTGACTTAAGTAACTGCTTGAGTAGTCTTCTAAGAGTTAGTCTTCGTAAAATAAATGGATAGGTATGTAAATATATAA
2161 TCTTACATACCCTTTCCAGCTTCCTAGAAAGGTCTACTGCTTCATCTTTTACAGATGTAAATAGGTCCAACCAGAGACAG
2241 TTTCTGGCCTTTGCATATAAGAATATAGATGTATACCACAGTATTATTTCAACAAAATGTTATGGTTCTATGTATAGTTG
2321 AAAACTCTATGATCAGCATACAACTGTCTTTTGGTAATTTTTAATGAAGTCTACATTTAGCCGTCGGTTTTATCTTTCTT
2401 AAATCTTTGACCTAAACTTTTGTAAGAGCAGCTAATAATTTCTAAGATTTTCCCTGTTTCTTTTTCCTACCTTTCCTTTT
2481 CTCATAACTGATTGGAGAAATTAATCAGAAGTCAAATACAAGGGACTTCATAATCTAGAAACCAGATAATCAGCTCCCAA
2561 GTCATGTAGCTAACTATGCATTTAAAATAAGTCTGTCTCTTTAGTTCTTAAGTCATATATTTGTTTGTTAATTACAGTAA
2641 ATGAACTTTAATTGGGGTTTTTAAAAGACAGAATTAGCGAAGTCTAATTTTTATAATGAAATAAGTTTTTGATATTGCTC
2721 TACTTGGACGATTTTAGTGACCAAAACTATGGATAAAACTGCCTAAGCATAACATTAATATATTTAGAATGGCATTCTTC
2801 AGTGCTAGTATTTGAAATTGGAATTAGTACATTGTGCATTCTTAGTAGTCTTTATCCCTAGAATCAATTCTCTCAGCATC
2881 ACCAAACTGAATTGGTGAAATAGTGCTAAGATTCTGGGCAATAGGAAGATTAGTGAATATGATACATTGATTCCAGGGTG
2961 CCAGGGATTGGCTGACATTAAGGACCAGCTGGCTATGGTCCTCAGGCTACGGTCCTCAGTATTCTAGTATTTGAGTAGTG
3041 GAGGTAAATCCAAAGGCGACTGGTTATATTTTACTTCTAAATGTGTGCTGAAGTGTCTCTTGTTCAAAAATTCTTGATAT
3121 TTAGAGCTTCAAGTTACCACATTTAAAAGTAAAGACTTGGCACGGTGGCACACACCTATAATCTTAGCACTTTGGGAGGC
3201 CGAAGTGGATGGATCATATGCAGTCAGGAATTTGAGACCAGCCTGGCCAACATGGTGAAACCTCATCTTTACTAAAAATA
3281 CAAAAATTAGCCGGGCGTTGTGACGCACACCCATAGTCCCAGCTAACTCCGGAGGCTAAGACAAGAGAATCACTTGAACT
3361 TGGGAGACAGAGGTTGCAGTAATCTGAGATCACTCCGCTGCACTCCAGCCTGAGTGAGAGTGAGACTGTGTCTCAAACAA
3441 ACAAACAAAAAACAAACAAAAAAATTTGCATTGTAAATTGTACCTCAAATTTGAGCAGTTTTTGTGTTTGTGTAAATTAA
3521 AGTAAAAAGCAGTCCACAATAATGTTTTGTAATACTGCACACCAGTTCTACCAGATTTTGTAACTATCAGATTTAAATGA
3601 AAAAAGAGAAGGAAGAGGCTGATTGCTGGAGTGTTAAAGAAATCTTGGCCGGGCGTGGTGGCTCACGCTTGTAATCCCAG
3681 CACTTTGGGAGGCCGAGGCGGGTGGATCACGAGGTCAGGAGATCGAGACCATCCTGGCTAACACGGTGAAACCCCGTCTC
3761 TACTAAAAATACAAAAAAAAATTAGCCGGGCGTGATGGCGGGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAAGA
3841 GAATGGCGTGAACCCGGGAGGCGGAGCTTGCAGTGAGCCGAGATTGCGCCACTGCACTCCCGCCTGGGCCACAGAGCGAG
3921 ACTCCGTCTCAAAAAAAAAAAAAAAAAAAAAAGAAATCTTTAGAAGCCACAGGGCTAGAAGAGAAGTCACCAAACACCTA
4001 GGGACAGTCCTAGGCCTAGAAAGCCCTTTAAAGTAATAGTGAATTGTTTTAAAATTAAGTTATTGAGTGGCCTACTGACT
4081 ACCATCCAAAAACCTTTATCACCAAATTTGTTCAGTGTTTGCTATTGGGAGATTGTCCATATCCCTCCGTAATTAAGGGC
4161 CAGCAAGTAATACGATCTTCTTACAGCCAACCTTGCTCTTCCCAAAGGGAGAAAGTAATACATCATTAACCTGGAATTTG
4241 TGATATAACAGGTAGCCTTGGTTAATGTTTACCTTTTCACTATGTAAAAAAGAAAAAACACACAGCAAATAGTGCAAATA
4321 AAATTTGGTCTTTTAAAGCATTTTAGCAGTAGCTATGTAAAAAAAGTTAATGGTTATTATTCCTAAATTTTCATAAGACC
4401 CTTGGTAGACAAAACTATCGGTTATATTATGTATATATGAGGTTAGTTAAGCTGCATTTAGTTAGGAACATTTAATTTTT
4481 ACCTAAATGATCCTTTTTTCATCCAGAGGTAGAGATTTTATTGTCATTATGAATGTTACTCCCCATTTAGTCCAAAATAG
4561 TGAGCTTTTAAGTTGTGCCAGGTACTTAACAATAGTAAAAGCTATTGTATAGATTTTTATTCAATGTGACCTATAATACA
4641 TTTCTGATTCCTTCTGTATTGAATGTCCCAGTTTCCATATTAAGTGCTATGCCCTGTATAACATTAATGAATTTAATAGT
4721 GTACAATTTTGGGCCAGGCATGGTGGCTCACGCCAGTAATCCTGGCACTTTGGGAGGCAGAGGCAGGCAGATCACCTGAG
4801 GTCAGGGGTTCGAGATCAGCCTGGCCAACATGGCAAAATCACATCTCTACTAAAAATACAAAAATTAGCCAGGCGTGGTG
4881 GTGCATGCCTGTAGTCCCAGCTACTCAGGAGGCTGAGGCAGGAGAATCGCTTGAACCCAGGAGGCGGAGGTTGCAGTGAG
4961 CCGAGATCATGCCATTGCACTCCAGCCTGGGAGACAGAGCAAGACTCTATCTCAAAAATAAAAATAAAAAAAAAATTGCG
5041 TGCAATTTTGTATTTTCATAGTCGTATCTTTTTAAAGGTATCATGATTTCAGTTGTGGTCAGGAAGTATGTGCCTTAAAT
5121 CCTCTACTCTAGACCCAAAGTTTGGAGAGCTATATTATTTAATAAGTTGTTTGTGACAGCCTTGTTACCTTTTTCATTTG
5201 ATTTGAGGGAGAAAGACTGTGATCCTGACAGATTCCTTCTCATAAAATGGCCTAATGTGTATCAGTCTAGGACTTCTGGG
5281 GAGGGAACCTCTACCATGCATTCTGTCCCAGGATGTCAAAGTCATAAGAATCAGGGTCCCCTGAAATAAAATCACTGAAA
5361 AGATATGTTCTGTTATATATTATTTAAAAAATTTATCTGGTGCCACCAAAGAATGACAGCAGTTTCTAACCAACTTCATA
5441 TTTATAGCATCTTATGAAGATATTGTAAGGCTTAGCATATTTTGCCACTGGTTTTCTTTGTAATATAGGTTGAAAGTGAG
5521 ACATGTTTGAATACTTTTGTATGTAAATATCTCCCATTCTTTTTCTATCTCTTCTTGGTCTATATTTACTAAGAATTGAT
5601 ATTTAAAAAACAGTTCACTAATGAACTCTACATATTATTGAACACTCACAGGGCAATATTGATTTGGGTGCTACTAGACT
5681 TTTACCTAACATTAGTCTTTCTCAATAGTTGTTGTAAAGGATAGTATTCAATCCAGTAAATATTAAAGTGTATTAGTTTA
5761 ATGAAGGTTATTTATATACTGTCATACCACAAACCTATGGTGGAAAGAACATCTGCATTCACCAGAATGTACTTGTTCCT
5841 TTGGCTGTGAATAAATTGGATAAGACTTTTTTATTGTAAGTTCCAGCTGTTGGAAGATACGGGGATAAGATTGACATTGC
5921 TGTTGCAGTATTGCAAAAACATGACTAAATTGGTTAATTATGTCTACCGCTTATGTTTAAGAGAATCCTTTCACTAACTT
6001 AAATTGTTAACATTGTTGTGATATTGAGAAAGAATATTAACCTAAACAGTCACTTTACAACAATCATGTAAAGACGTGTG
6081 CCTGCAGTTGAGGTTTTTTGCATTTCTGAGCCTGCTTTGTATTCATGAGAAACAAAAACATAATGGGAGAAAAGTTTTAG
6161 ATAAGCAGCATTGTAAGTTTTTGTAAAGTTTGGGATGTCAAAGTATTAACGAAGGGTACTGAAAACATACTTTTACTTGG
6241 GTCAAATTACTTTTTATGATCTGATTTCTTAATTTTCTGTATTTGAAATCTTGCAAATTAGGAATATCTACATCTATAGA
6321 TAAATAAGTAAAACTTAATGGTAGAAATAAGTGTAATTCAGCAACATGATTCAACAATTTTTATATTTAGGATAAGTTAT
6401 TGTTTATTATATTAATATCAAATTTATATATTGCCTTGTAATGCTAAATGCTCTTAAAAGAATATATGGGC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuUGUAUUGUGCCUAUUGGAGa 5'
            |:||||||  |:||:|||: 
Target 5' tgATATAACA--GGTAGCCTTg 3'
 4241 - 4260 140.00 -15.00
2 
miRNA  3' cuuGUAUUG-UGCCUAUUGGAga 5'
             || |:| ||  |||||||  
Target 5' tgcCAGAGCAACCTATAACCTga 3'
 730 - 752 139.00 -8.70
3 
miRNA  3' cuUGUAUU-GUGCCUAUUGGAGa 5'
            |:||:| ::|   ||||||: 
Target 5' ctATATGATTGCTATTAACCTTa 3'
 639 - 661 136.00 -7.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30471121 17 COSMIC
COSN30117570 29 COSMIC
COSN31508220 51 COSMIC
COSN14025160 78 COSMIC
COSN32077531 158 COSMIC
COSN29852146 251 COSMIC
COSN25204462 479 COSMIC
COSN1910659 581 COSMIC
COSN1910658 911 COSMIC
COSN7814411 926 COSMIC
COSN6747392 1020 COSMIC
COSN1910657 1093 COSMIC
COSN16712171 1171 COSMIC
COSN1910656 1203 COSMIC
COSN6747391 1237 COSMIC
COSN16971038 1311 COSMIC
COSN24981872 1546 COSMIC
COSN29860294 1616 COSMIC
COSN23394149 1676 COSMIC
COSN7814410 1925 COSMIC
COSN31962131 2831 COSMIC
COSN20098924 3434 COSMIC
COSN20090880 3488 COSMIC
COSN29525920 3507 COSMIC
COSN17181986 3546 COSMIC
COSN20090879 3953 COSMIC
COSN25202458 4042 COSMIC
COSN25259110 4047 COSMIC
COSN25204773 4057 COSMIC
COSN25204191 4099 COSMIC
COSN25201893 4178 COSMIC
COSN31962130 4420 COSMIC
COSN20711065 4669 COSMIC
COSN7814408 4676 COSMIC
COSN29178124 4750 COSMIC
COSN9735459 4875 COSMIC
COSN15100227 4980 COSMIC
COSN27309566 5025 COSMIC
COSN17415574 5031 COSMIC
COSN22697323 5039 COSMIC
COSN32057640 5175 COSMIC
COSN6747390 5390 COSMIC
COSN20098923 5900 COSMIC
COSN1910655 6299 COSMIC
COSN2504084 6385 COSMIC
COSN18944673 6618 COSMIC
rs10511400 6211 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs756619195 1 dbSNP
rs1240654087 2 dbSNP
rs1346727075 3 dbSNP
rs1334844452 4 dbSNP
rs1484543150 10 dbSNP
rs372468489 11 dbSNP
rs77005092 13 dbSNP
rs757355348 27 dbSNP
rs376883169 33 dbSNP
rs1164136147 34 dbSNP
rs764292107 36 dbSNP
rs763227362 38 dbSNP
rs776343293 46 dbSNP
rs766169633 47 dbSNP
rs760624843 48 dbSNP
rs1400275518 54 dbSNP
rs960070905 58 dbSNP
rs969587391 60 dbSNP
rs1281064561 62 dbSNP
rs1031393478 64 dbSNP
rs561092787 78 dbSNP
rs959807826 81 dbSNP
rs1448425314 89 dbSNP
rs904330012 90 dbSNP
rs1406422909 95 dbSNP
rs1372161508 99 dbSNP
rs1021405409 102 dbSNP
rs1221675173 103 dbSNP
rs1282620860 111 dbSNP
rs562802423 112 dbSNP
rs899729076 116 dbSNP
rs114533645 117 dbSNP
rs1180595627 120 dbSNP
rs542629162 128 dbSNP
rs1469841035 129 dbSNP
rs1171154486 132 dbSNP
rs564893232 141 dbSNP
rs1175752227 143 dbSNP
rs887209503 147 dbSNP
rs111898403 152 dbSNP
rs1040888688 154 dbSNP
rs1403833818 158 dbSNP
rs1201813280 166 dbSNP
rs1467058946 177 dbSNP
rs1331476408 182 dbSNP
rs944112409 192 dbSNP
rs914011290 203 dbSNP
rs375577960 208 dbSNP
rs1262549996 212 dbSNP
rs1217520249 213 dbSNP
rs182816221 215 dbSNP
rs925488595 218 dbSNP
rs1201024190 228 dbSNP
rs1274299359 230 dbSNP
rs1202521551 231 dbSNP
rs1248734173 240 dbSNP
rs1478445221 249 dbSNP
rs1198428188 261 dbSNP
rs1426891263 265 dbSNP
rs879685808 266 dbSNP
rs1286313563 270 dbSNP
rs981043837 271 dbSNP
rs1407776278 273 dbSNP
rs1198683654 285 dbSNP
rs1324935502 289 dbSNP
rs1343980706 296 dbSNP
rs1350117328 298 dbSNP
rs1403914714 304 dbSNP
rs920126981 314 dbSNP
rs1283687440 317 dbSNP
rs980935332 318 dbSNP
rs948339348 320 dbSNP
rs948309639 334 dbSNP
rs191444605 336 dbSNP
rs376367587 338 dbSNP
rs992353454 341 dbSNP
rs959691616 342 dbSNP
rs1430878072 353 dbSNP
rs1212895939 387 dbSNP
rs553400645 400 dbSNP
rs1347442129 408 dbSNP
rs1332722541 410 dbSNP
rs1490583778 413 dbSNP
rs977174183 416 dbSNP
rs1221960260 424 dbSNP
rs1414434617 427 dbSNP
rs959755714 431 dbSNP
rs968435685 440 dbSNP
rs1015367032 442 dbSNP
rs1407217606 445 dbSNP
rs1474349191 448 dbSNP
rs1021436631 449 dbSNP
rs952413429 451 dbSNP
rs1423433981 454 dbSNP
rs534530954 456 dbSNP
rs962098671 456 dbSNP
rs1319327109 457 dbSNP
rs1326361915 458 dbSNP
rs540757524 458 dbSNP
rs1464257115 462 dbSNP
rs574672462 462 dbSNP
rs899760809 463 dbSNP
rs1187158279 465 dbSNP
rs1289945522 478 dbSNP
rs1356104044 483 dbSNP
rs1205513590 485 dbSNP
rs899775651 498 dbSNP
rs1019387927 500 dbSNP
rs1019504867 510 dbSNP
rs1008648427 511 dbSNP
rs139581636 514 dbSNP
rs1052475680 521 dbSNP
rs150172629 530 dbSNP
rs1381795732 535 dbSNP
rs866310363 542 dbSNP
rs901708760 546 dbSNP
rs537942328 550 dbSNP
rs898565311 551 dbSNP
rs1399298279 556 dbSNP
rs76016896 560 dbSNP
rs1257087867 564 dbSNP
rs948219677 569 dbSNP
rs1312939070 571 dbSNP
rs1379397120 577 dbSNP
rs74835786 578 dbSNP
rs1260345007 579 dbSNP
rs1348330400 584 dbSNP
rs538619441 590 dbSNP
rs1056682945 602 dbSNP
rs1447873649 605 dbSNP
rs1263741346 607 dbSNP
rs757229023 610 dbSNP
rs935572204 613 dbSNP
rs992301149 616 dbSNP
rs1201237243 620 dbSNP
rs924338975 626 dbSNP
rs184956539 627 dbSNP
rs968468293 630 dbSNP
rs1419324945 631 dbSNP
rs1180706942 634 dbSNP
rs1361673550 639 dbSNP
rs1468982221 640 dbSNP
rs1179009981 641 dbSNP
rs147395407 643 dbSNP
rs1469676668 649 dbSNP
rs908250023 651 dbSNP
rs1402614055 652 dbSNP
rs975235479 660 dbSNP
rs982547628 675 dbSNP
rs1306645961 677 dbSNP
rs1171346995 682 dbSNP
rs963873227 683 dbSNP
rs1334191956 688 dbSNP
rs1235159852 690 dbSNP
rs1283613009 692 dbSNP
rs952602555 699 dbSNP
rs142809861 700 dbSNP
rs1008181331 702 dbSNP
rs1480696549 704 dbSNP
rs1194732485 707 dbSNP
rs951374396 715 dbSNP
rs1025675964 717 dbSNP
rs995496541 719 dbSNP
rs1430366894 720 dbSNP
rs898597867 738 dbSNP
rs1480303271 741 dbSNP
rs180887546 749 dbSNP
rs1375285557 752 dbSNP
rs2638597 755 dbSNP
rs1456241890 762 dbSNP
rs896684951 772 dbSNP
rs1057030368 781 dbSNP
rs1394615381 782 dbSNP
rs892297829 785 dbSNP
rs1406951764 788 dbSNP
rs9845571 795 dbSNP
rs189840702 808 dbSNP
rs1031286234 816 dbSNP
rs935618823 820 dbSNP
rs1307987809 823 dbSNP
rs878915283 824 dbSNP
rs1041377817 826 dbSNP
rs947030208 835 dbSNP
rs1249041977 838 dbSNP
rs1045050781 849 dbSNP
rs1222837156 849 dbSNP
rs914326108 857 dbSNP
rs948065374 861 dbSNP
rs1490309168 865 dbSNP
rs112124625 867 dbSNP
rs1264498168 869 dbSNP
rs964120856 878 dbSNP
rs912419086 880 dbSNP
rs77579461 893 dbSNP
rs908033061 909 dbSNP
rs545072227 910 dbSNP
rs572777662 917 dbSNP
rs1348424718 919 dbSNP
rs931059093 926 dbSNP
rs1425436690 929 dbSNP
rs6438575 930 dbSNP
rs1165354697 940 dbSNP
rs975078360 940 dbSNP
rs1341792162 952 dbSNP
rs1437758120 954 dbSNP
rs1246073226 957 dbSNP
rs1406905670 968 dbSNP
rs1177630411 977 dbSNP
rs1025530437 987 dbSNP
rs1262826039 990 dbSNP
rs1486493775 992 dbSNP
rs995527883 994 dbSNP
rs61020295 999 dbSNP
rs1221305404 1003 dbSNP
rs1490357843 1013 dbSNP
rs1384857785 1016 dbSNP
rs1293325347 1019 dbSNP
rs1161055709 1027 dbSNP
rs1345513447 1036 dbSNP
rs1452749961 1037 dbSNP
rs1238535258 1039 dbSNP
rs865806882 1040 dbSNP
rs1287116216 1045 dbSNP
rs1384895792 1047 dbSNP
rs1485920280 1059 dbSNP
rs1452750901 1065 dbSNP
rs1316900866 1068 dbSNP
rs1308151491 1072 dbSNP
rs1225065983 1082 dbSNP
rs758558397 1082 dbSNP
rs574747959 1101 dbSNP
rs752293365 1105 dbSNP
rs1225875548 1106 dbSNP
rs1307238539 1107 dbSNP
rs1023629089 1110 dbSNP
rs182586877 1112 dbSNP
rs896561602 1117 dbSNP
rs1030816306 1120 dbSNP
rs1001127262 1121 dbSNP
rs968132832 1128 dbSNP
rs1405815721 1130 dbSNP
rs538093268 1132 dbSNP
rs1242564330 1138 dbSNP
rs549140080 1147 dbSNP
rs1179219036 1148 dbSNP
rs1408981560 1150 dbSNP
rs1418346218 1151 dbSNP
rs1156601337 1154 dbSNP
rs1024149568 1156 dbSNP
rs1470219655 1158 dbSNP
rs1012217313 1160 dbSNP
rs1035229125 1161 dbSNP
rs1403330551 1175 dbSNP
rs1000068428 1183 dbSNP
rs1443699702 1184 dbSNP
rs1298457811 1190 dbSNP
rs896483464 1192 dbSNP
rs1223592810 1206 dbSNP
rs1286770642 1209 dbSNP
rs189944566 1218 dbSNP
rs1263036401 1225 dbSNP
rs1233684457 1228 dbSNP
rs1480394335 1228 dbSNP
rs555663595 1228 dbSNP
rs902775628 1235 dbSNP
rs1431094989 1237 dbSNP
rs1480629119 1239 dbSNP
rs1420601889 1242 dbSNP
rs1043932868 1244 dbSNP
rs767156035 1252 dbSNP
rs1480566867 1253 dbSNP
rs1270395831 1254 dbSNP
rs947067599 1255 dbSNP
rs1353565297 1263 dbSNP
rs867899180 1269 dbSNP
rs1213908096 1280 dbSNP
rs1306584064 1285 dbSNP
rs892832612 1287 dbSNP
rs919651736 1288 dbSNP
rs1405897419 1290 dbSNP
rs1039758032 1291 dbSNP
rs1343422593 1297 dbSNP
rs1216410947 1299 dbSNP
rs942502741 1313 dbSNP
rs768677224 1315 dbSNP
rs540484351 1322 dbSNP
rs575420643 1322 dbSNP
rs1490470757 1324 dbSNP
rs1198402313 1325 dbSNP
rs1266697956 1333 dbSNP
rs773832699 1344 dbSNP
rs1168019012 1349 dbSNP
rs1310768165 1354 dbSNP
rs1262918778 1362 dbSNP
rs1165124748 1373 dbSNP
rs986657573 1374 dbSNP
rs1425706371 1383 dbSNP
rs1302857875 1385 dbSNP
rs1433444249 1402 dbSNP
rs986454422 1402 dbSNP
rs929754203 1403 dbSNP
rs1361410856 1406 dbSNP
rs1226270339 1414 dbSNP
rs1294294231 1429 dbSNP
rs1360367341 1430 dbSNP
rs6800402 1432 dbSNP
rs979256977 1437 dbSNP
rs1448680677 1438 dbSNP
rs16831036 1444 dbSNP
rs771787784 1445 dbSNP
rs1023505696 1447 dbSNP
rs185318645 1447 dbSNP
rs1447204968 1448 dbSNP
rs181100405 1455 dbSNP
rs367717432 1460 dbSNP
rs1362773676 1466 dbSNP
rs1163367731 1471 dbSNP
rs370137564 1479 dbSNP
rs63614760 1479 dbSNP
rs11432800 1480 dbSNP
rs374402298 1482 dbSNP
rs1402776161 1491 dbSNP
rs567612427 1496 dbSNP
rs1345099442 1498 dbSNP
rs1004904432 1499 dbSNP
rs1175513017 1509 dbSNP
rs991220703 1512 dbSNP
rs1317163126 1515 dbSNP
rs1383836500 1531 dbSNP
rs1245459555 1535 dbSNP
rs539560261 1538 dbSNP
rs1352622174 1543 dbSNP
rs1284511711 1546 dbSNP
rs1469988804 1549 dbSNP
rs1431024990 1550 dbSNP
rs960831293 1555 dbSNP
rs1283498124 1560 dbSNP
rs115995323 1566 dbSNP
rs1427360552 1568 dbSNP
rs201567230 1569 dbSNP
rs530759440 1569 dbSNP
rs1443462302 1570 dbSNP
rs150178913 1571 dbSNP
rs747334370 1574 dbSNP
rs200652407 1580 dbSNP
rs900660628 1584 dbSNP
rs1407895559 1585 dbSNP
rs1456071135 1591 dbSNP
rs780160071 1595 dbSNP
rs1039206810 1600 dbSNP
rs570451121 1610 dbSNP
rs141408238 1615 dbSNP
rs1011135613 1635 dbSNP
rs1262900535 1638 dbSNP
rs900759107 1646 dbSNP
rs778440933 1650 dbSNP
rs923844110 1664 dbSNP
rs528153479 1676 dbSNP
rs1460544155 1678 dbSNP
rs1325892314 1684 dbSNP
rs1252244999 1690 dbSNP
rs1437978581 1695 dbSNP
rs559093760 1698 dbSNP
rs942324607 1701 dbSNP
rs1471801893 1711 dbSNP
rs1179257098 1713 dbSNP
rs890880466 1715 dbSNP
rs916384548 1719 dbSNP
rs1170827820 1721 dbSNP
rs1398948527 1725 dbSNP
rs1392132619 1737 dbSNP
rs1328409497 1759 dbSNP
rs1051261182 1760 dbSNP
rs1348448474 1761 dbSNP
rs76566364 1763 dbSNP
rs1406545102 1774 dbSNP
rs1283916815 1779 dbSNP
rs929700501 1780 dbSNP
rs188739327 1782 dbSNP
rs1230441377 1793 dbSNP
rs1252511444 1796 dbSNP
rs1339680322 1809 dbSNP
rs960755890 1810 dbSNP
rs918449140 1813 dbSNP
rs1035116268 1823 dbSNP
rs1482316871 1838 dbSNP
rs148307306 1845 dbSNP
rs145013589 1852 dbSNP
rs573025454 1856 dbSNP
rs34715000 1860 dbSNP
rs1196876352 1861 dbSNP
rs1453167732 1866 dbSNP
rs1408058580 1879 dbSNP
rs1462534961 1891 dbSNP
rs1168273930 1901 dbSNP
rs141281821 1917 dbSNP
rs757318149 1928 dbSNP
rs1366854979 1938 dbSNP
rs960968289 1949 dbSNP
rs753836777 1953 dbSNP
rs11716277 1954 dbSNP
rs1326543677 1963 dbSNP
rs966746171 1965 dbSNP
rs1272109535 1972 dbSNP
rs562864640 1974 dbSNP
rs1011020995 1980 dbSNP
rs1225228692 1982 dbSNP
rs890843735 1983 dbSNP
rs9859833 1996 dbSNP
rs1184772921 1999 dbSNP
rs1050807180 2016 dbSNP
rs1208622241 2019 dbSNP
rs935136485 2026 dbSNP
rs1236730835 2034 dbSNP
rs1187943637 2043 dbSNP
rs1195383171 2055 dbSNP
rs781548092 2059 dbSNP
rs1018232530 2068 dbSNP
rs1481114960 2074 dbSNP
rs573242486 2076 dbSNP
rs145749987 2079 dbSNP
rs1242749750 2089 dbSNP
rs1043424612 2090 dbSNP
rs1357160919 2091 dbSNP
rs573787091 2098 dbSNP
rs1433727715 2120 dbSNP
rs1294679635 2124 dbSNP
rs536686232 2124 dbSNP
rs946605603 2125 dbSNP
rs755537897 2128 dbSNP
rs890817673 2147 dbSNP
rs1313883521 2160 dbSNP
rs1246665995 2162 dbSNP
rs1384640209 2166 dbSNP
rs1050767540 2167 dbSNP
rs1263034618 2176 dbSNP
rs767127912 2178 dbSNP
rs916516889 2184 dbSNP
rs990623057 2194 dbSNP
rs939174357 2196 dbSNP
rs1413341178 2199 dbSNP
rs796669321 2201 dbSNP
rs370501794 2203 dbSNP
rs896901384 2210 dbSNP
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rs1038219484 2228 dbSNP
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rs916519680 2264 dbSNP
rs751864560 2266 dbSNP
rs1326622951 2271 dbSNP
rs557320462 2273 dbSNP
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rs1301959349 2283 dbSNP
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rs760696192 3018 dbSNP
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rs1290344862 4024 dbSNP
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rs1215567547 4939 dbSNP
rs1274077280 4941 dbSNP
rs138097645 4946 dbSNP
rs1050073346 4950 dbSNP
rs1263667275 4952 dbSNP
rs996366950 4961 dbSNP
rs1237865421 4962 dbSNP
rs994814587 4969 dbSNP
rs897429620 4970 dbSNP
rs541699868 4971 dbSNP
rs1017497379 4973 dbSNP
rs76734190 4979 dbSNP
rs887488879 4980 dbSNP
rs1289651490 4982 dbSNP
rs1290267289 4986 dbSNP
rs1387672476 4996 dbSNP
rs1383073438 5005 dbSNP
rs751415529 5008 dbSNP
rs1344353717 5009 dbSNP
rs1235241665 5010 dbSNP
rs1324705526 5019 dbSNP
rs186600330 5025 dbSNP
rs1212118507 5026 dbSNP
rs1262653087 5026 dbSNP
rs545891926 5031 dbSNP
rs143259912 5036 dbSNP
rs901491357 5036 dbSNP
rs116698900 5038 dbSNP
rs930559033 5039 dbSNP
rs116083434 5040 dbSNP
rs1160858678 5042 dbSNP
rs1054660453 5046 dbSNP
rs1363953275 5050 dbSNP
rs935824512 5052 dbSNP
rs927152039 5058 dbSNP
rs980176422 5064 dbSNP
rs181774681 5066 dbSNP
rs1174562630 5068 dbSNP
rs1480111849 5084 dbSNP
rs1354916824 5091 dbSNP
rs971502533 5092 dbSNP
rs568044010 5106 dbSNP
rs971463612 5109 dbSNP
rs1247394675 5113 dbSNP
rs1317690173 5114 dbSNP
rs917221753 5115 dbSNP
rs1258787365 5121 dbSNP
rs1349782804 5123 dbSNP
rs1199424124 5132 dbSNP
rs1484407467 5137 dbSNP
rs1178391246 5143 dbSNP
rs917291526 5152 dbSNP
rs1418199727 5155 dbSNP
rs972778688 5166 dbSNP
rs1378914434 5167 dbSNP
rs58174591 5175 dbSNP
rs1174820359 5180 dbSNP
rs1375327184 5190 dbSNP
rs1204398958 5202 dbSNP
rs1445937155 5208 dbSNP
rs189185587 5209 dbSNP
rs1269559166 5229 dbSNP
rs1374106120 5230 dbSNP
rs1033167697 5235 dbSNP
rs1307335036 5239 dbSNP
rs1221341121 5240 dbSNP
rs375888325 5250 dbSNP
rs774744864 5253 dbSNP
rs1274978902 5256 dbSNP
rs1279562160 5259 dbSNP
rs1236033014 5273 dbSNP
rs1206512316 5278 dbSNP
rs1251450940 5279 dbSNP
rs1325274878 5282 dbSNP
rs56401132 5284 dbSNP
rs954203171 5291 dbSNP
rs1028475709 5293 dbSNP
rs1455876985 5304 dbSNP
rs1436199176 5322 dbSNP
rs1194599288 5324 dbSNP
rs995863049 5325 dbSNP
rs771227696 5331 dbSNP
rs1413304343 5338 dbSNP
rs901610202 5350 dbSNP
rs1355248966 5351 dbSNP
rs1040414090 5352 dbSNP
rs1009910673 5357 dbSNP
rs891665546 5363 dbSNP
rs1441395000 5367 dbSNP
rs1302474720 5368 dbSNP
rs1334920211 5372 dbSNP
rs749429766 5375 dbSNP
rs1216314951 5378 dbSNP
rs1296135304 5379 dbSNP
rs1306417999 5380 dbSNP
rs115351836 5383 dbSNP
rs935939809 5386 dbSNP
rs1425929235 5391 dbSNP
rs1212644757 5393 dbSNP
rs927100053 5395 dbSNP
rs1478963439 5400 dbSNP
rs1188818466 5403 dbSNP
rs550062632 5405 dbSNP
rs1044275977 5416 dbSNP
rs950155658 5419 dbSNP
rs917354549 5421 dbSNP
rs973111530 5422 dbSNP
rs185695483 5424 dbSNP
rs909908443 5425 dbSNP
rs1432554626 5428 dbSNP
rs570898711 5444 dbSNP
rs984322914 5447 dbSNP
rs769688132 5448 dbSNP
rs1216693675 5455 dbSNP
rs748104375 5460 dbSNP
rs750837644 5465 dbSNP
rs954317987 5469 dbSNP
rs1232364001 5477 dbSNP
rs1287236917 5483 dbSNP
rs1249688888 5508 dbSNP
rs1450245675 5509 dbSNP
rs547472416 5521 dbSNP
rs1028423034 5524 dbSNP
rs1201362605 5534 dbSNP
rs1468801327 5536 dbSNP
rs1488278969 5537 dbSNP
rs77831221 5539 dbSNP
rs78492267 5541 dbSNP
rs1010442454 5542 dbSNP
rs1411847341 5551 dbSNP
rs891455552 5553 dbSNP
rs1336896486 5556 dbSNP
rs1054153617 5557 dbSNP
rs1000097103 5558 dbSNP
rs1314629062 5565 dbSNP
rs1355558009 5567 dbSNP
rs1413560154 5567 dbSNP
rs569144895 5567 dbSNP
rs1223975268 5570 dbSNP
rs1229826171 5574 dbSNP
rs949922341 5577 dbSNP
rs1313434279 5580 dbSNP
rs746770161 5584 dbSNP
rs895850052 5593 dbSNP
rs181413890 5606 dbSNP
rs940128786 5626 dbSNP
rs1235783724 5629 dbSNP
rs1360030071 5632 dbSNP
rs1471302730 5638 dbSNP
rs1159360826 5643 dbSNP
rs74584088 5645 dbSNP
rs1417572246 5646 dbSNP
rs1408216506 5656 dbSNP
rs984103491 5676 dbSNP
rs1433585495 5679 dbSNP
rs1331690650 5685 dbSNP
rs1336986822 5686 dbSNP
rs1442576157 5691 dbSNP
rs1395905513 5695 dbSNP
rs753799616 5702 dbSNP
rs932874496 5705 dbSNP
rs1238373933 5708 dbSNP
rs369241303 5712 dbSNP
rs545725088 5716 dbSNP
rs1391753653 5721 dbSNP
rs976847111 5737 dbSNP
rs1276670635 5743 dbSNP
rs965570126 5747 dbSNP
rs1237635923 5748 dbSNP
rs1021577647 5750 dbSNP
rs1437628521 5765 dbSNP
rs1195213648 5767 dbSNP
rs1395433168 5770 dbSNP
rs1465522196 5770 dbSNP
rs551207327 5780 dbSNP
rs1398085899 5781 dbSNP
rs1435525633 5786 dbSNP
rs1327801542 5787 dbSNP
rs1273312671 5788 dbSNP
rs1442615250 5791 dbSNP
rs1327821595 5792 dbSNP
rs1306138024 5802 dbSNP
rs1372175040 5809 dbSNP
rs764305124 5812 dbSNP
rs1233229516 5813 dbSNP
rs1206466090 5817 dbSNP
rs1341568936 5825 dbSNP
rs560022723 5825 dbSNP
rs1196415616 5833 dbSNP
rs1257692238 5844 dbSNP
rs1456647339 5852 dbSNP
rs956008385 5860 dbSNP
rs540305477 5876 dbSNP
rs564442099 5878 dbSNP
rs79564081 5900 dbSNP
rs34220764 5901 dbSNP
rs529591924 5901 dbSNP
rs188135650 5902 dbSNP
rs1286139897 5905 dbSNP
rs1420789829 5905 dbSNP
rs1462750625 5911 dbSNP
rs1326151268 5925 dbSNP
rs1391918172 5926 dbSNP
rs1386496416 5933 dbSNP
rs1322182549 5939 dbSNP
rs1440323645 5950 dbSNP
rs1228767196 5956 dbSNP
rs1335226222 5959 dbSNP
rs999877392 5960 dbSNP
rs905745175 5965 dbSNP
rs1430328330 5968 dbSNP
rs1022891491 5974 dbSNP
rs1372393835 5985 dbSNP
rs1488051974 5992 dbSNP
rs1014621016 5993 dbSNP
rs895637174 5996 dbSNP
rs1404478340 5999 dbSNP
rs554567225 6013 dbSNP
rs1367492667 6015 dbSNP
rs1475868056 6015 dbSNP
rs1183188640 6023 dbSNP
rs1468323517 6065 dbSNP
rs1250382745 6067 dbSNP
rs369286488 6075 dbSNP
rs142768626 6076 dbSNP
rs1298113985 6078 dbSNP
rs576712562 6083 dbSNP
rs1048347094 6088 dbSNP
rs1416627942 6100 dbSNP
rs1267308596 6140 dbSNP
rs1321399041 6151 dbSNP
rs1242836856 6158 dbSNP
rs1262334320 6160 dbSNP
rs556809467 6168 dbSNP
rs1221525310 6170 dbSNP
rs1215822922 6175 dbSNP
rs932655263 6178 dbSNP
rs1486383800 6190 dbSNP
rs1292535850 6200 dbSNP
rs560214169 6203 dbSNP
rs1254844330 6205 dbSNP
rs1421729404 6210 dbSNP
rs10511400 6211 dbSNP
rs1365976295 6220 dbSNP
rs1420634557 6227 dbSNP
rs1289053919 6237 dbSNP
rs571003802 6240 dbSNP
rs201759328 6245 dbSNP
rs944319793 6259 dbSNP
rs1303535883 6261 dbSNP
rs1378521667 6267 dbSNP
rs1394566350 6270 dbSNP
rs1309349634 6279 dbSNP
rs914057284 6282 dbSNP
rs372526673 6288 dbSNP
rs988736112 6295 dbSNP
rs1411675796 6296 dbSNP
rs955746719 6303 dbSNP
rs1283829074 6304 dbSNP
rs1350027356 6308 dbSNP
rs1211467461 6316 dbSNP
rs116389131 6317 dbSNP
rs1301174354 6328 dbSNP
rs978385226 6328 dbSNP
rs374147203 6348 dbSNP
rs1022665789 6349 dbSNP
rs1014153701 6351 dbSNP
rs1350228580 6355 dbSNP
rs1456013858 6367 dbSNP
rs1166701525 6372 dbSNP
rs895738755 6377 dbSNP
rs1015397505 6378 dbSNP
rs1464549181 6383 dbSNP
rs184498984 6399 dbSNP
rs1401239161 6400 dbSNP
rs568124392 6409 dbSNP
rs1159459960 6414 dbSNP
rs1473246483 6415 dbSNP
rs1048457809 6426 dbSNP
rs548130258 6442 dbSNP
rs1191104017 6445 dbSNP
rs1205962823 6446 dbSNP
rs1258333537 6460 dbSNP
rs1457071269 6460 dbSNP
rs531727221 6460 dbSNP
rs193052429 6465 dbSNP
rs758013127 6466 dbSNP
rs190686962 6468 dbSNP
rs1041468826 6469 dbSNP
rs1268929810 6473 dbSNP
rs1230495563 6479 dbSNP
rs1424387289 6484 dbSNP
rs1321442467 6490 dbSNP
rs1300734975 6491 dbSNP
rs1329546558 6496 dbSNP
rs1396433434 6497 dbSNP
rs1436854543 6504 dbSNP
rs944281256 6510 dbSNP
rs185680218 6511 dbSNP
rs1216222457 6512 dbSNP
rs1052582782 6522 dbSNP
rs1428307304 6525 dbSNP
rs936825748 6526 dbSNP
rs925481302 6527 dbSNP
rs1323910869 6534 dbSNP
rs749965464 6540 dbSNP
rs1246466106 6547 dbSNP
rs778469548 6550 dbSNP
rs1458537403 6553 dbSNP
rs969818157 6562 dbSNP
rs1426553100 6565 dbSNP
rs1477504204 6576 dbSNP
rs56341074 6577 dbSNP
rs1168806005 6585 dbSNP
rs1405765370 6589 dbSNP
rs915554752 6589 dbSNP
rs992916198 6591 dbSNP
rs560358143 6603 dbSNP
rs1015927168 6609 dbSNP
rs1004122189 6613 dbSNP
rs1434245942 6618 dbSNP
rs952537430 6622 dbSNP
rs1185290988 6626 dbSNP
rs1026806425 6628 dbSNP
rs1449203687 6630 dbSNP
rs1000877001 6632 dbSNP
rs191991890 6634 dbSNP
rs954315370 6638 dbSNP
rs200918482 6642 dbSNP
rs1210797799 6646 dbSNP
rs1289700755 6647 dbSNP
rs1460181153 6650 dbSNP
rs996871587 6653 dbSNP
rs1255482562 6654 dbSNP
rs1488024101 6659 dbSNP
rs899947628 6660 dbSNP
rs574540421 6666 dbSNP
rs560963164 6668 dbSNP
rs1210980585 6670 dbSNP
rs1314034280 6671 dbSNP
rs1411370266 6672 dbSNP
rs1402158337 6673 dbSNP
rs1303228190 6677 dbSNP
rs767607140 6681 dbSNP
rs901613280 6682 dbSNP
rs1053113740 6687 dbSNP
rs1436829226 6692 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cuuguauugugccuaUUGGAGa 5'
                         |||||| 
Target 5' --------------aAACCUCa 3'
 		1 - 8
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 116064.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM714644. RNA binding protein: AGO2. Condition:completeT1 "PAR-CLIP data was present in GSM714645. RNA binding protein: AGO2. Condition:completeT1 ...

- Kishore S; Jaskiewicz L; Burger L; Hausser et al., 2011, Nature methods.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cuuguauugugccuaUUGGAGa 5'
                         |||||| 
Target 5' ---------------AACCUCa 3'
 		1 - 7
Article - Kishore S; Jaskiewicz L; Burger L; Hausser et al.
- Nature methods, 2011
Cross-linking and immunoprecipitation (CLIP) is increasingly used to map transcriptome-wide binding sites of RNA-binding proteins. We developed a method for CLIP data analysis, and applied it to compare CLIP with photoactivatable ribonucleoside-enhanced CLIP (PAR-CLIP) and to uncover how differences in cross-linking and ribonuclease digestion affect the identified sites. We found only small differences in accuracies of these methods in identifying binding sites of HuR, which binds low-complexity sequences, and Argonaute 2, which has a complex binding specificity. We found that cross-link-induced mutations led to single-nucleotide resolution for both PAR-CLIP and CLIP. Our results confirm the expectation from original CLIP publications that RNA-binding proteins do not protect their binding sites sufficiently under the denaturing conditions used during the CLIP procedure, and we show that extensive digestion with sequence-specific RNases strongly biases the recovered binding sites. This bias can be substantially reduced by milder nuclease digestion conditions.
LinkOut: [PMID: 21572407]
Experimental Support 3 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 116064.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000295628.3 | 3UTR | AAACCUCAUCUUUACUAAAAAUACAAAAAUUA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM714644
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repA
Location of target site ENST00000295628.3 | 3UTR | CAUCUUUACUAAAAAU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM714645
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / completeT1, repB
Location of target site ENST00000295628.3 | 3UTR | AACCUCAUCUUUACUAAAAAUACAAAAA
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 21572407 / GSE28865
CLIP-seq Viewer Link
CLIP-seq Support 4 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000295628.3 | 3UTR | AAACCUCAUCUUUACUAAAAAUACAAAAAUUAG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
91 hsa-miR-655-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT080691 KIAA1468 KIAA1468 2 2
MIRT095086 SEC24A SEC24 homolog A, COPII coat complex component 2 4
MIRT122450 SMIM13 small integral membrane protein 13 2 2
MIRT214635 SMAD5 SMAD family member 5 2 4
MIRT268267 CCND1 cyclin D1 2 2
MIRT312418 GRPEL2 GrpE like 2, mitochondrial 2 2
MIRT329008 DSTN destrin, actin depolymerizing factor 2 2
MIRT329824 PDCD4 programmed cell death 4 2 4
MIRT389635 LRRC58 leucine rich repeat containing 58 2 6
MIRT443969 FAM198B family with sequence similarity 198 member B 2 2
MIRT444080 C12orf73 chromosome 12 open reading frame 73 2 2
MIRT444886 TMEM196 transmembrane protein 196 2 2
MIRT445506 CRNKL1 crooked neck pre-mRNA splicing factor 1 2 4
MIRT446292 ACSL3 acyl-CoA synthetase long chain family member 3 2 2
MIRT446462 THAP1 THAP domain containing 1 2 2
MIRT446472 THUMPD3 THUMP domain containing 3 2 2
MIRT447413 MED21 mediator complex subunit 21 2 2
MIRT447491 KIAA1715 lunapark, ER junction formation factor 2 2
MIRT448965 CDADC1 cytidine and dCMP deaminase domain containing 1 2 2
MIRT449602 INIP INTS3 and NABP interacting protein 2 2
MIRT449607 PRPF4 pre-mRNA processing factor 4 2 2
MIRT449737 TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 2 2
MIRT451668 KRT8 keratin 8 2 4
MIRT452424 QDPR quinoid dihydropteridine reductase 2 2
MIRT455187 AGTRAP angiotensin II receptor associated protein 2 2
MIRT456059 SLC25A28 solute carrier family 25 member 28 2 2
MIRT456488 SERAC1 serine active site containing 1 2 2
MIRT456631 ARMCX6 armadillo repeat containing, X-linked 6 2 2
MIRT459621 SLC25A33 solute carrier family 25 member 33 2 2
MIRT461162 SLC11A2 solute carrier family 11 member 2 2 4
MIRT461990 PACSIN1 protein kinase C and casein kinase substrate in neurons 1 2 2
MIRT463149 ZNF385A zinc finger protein 385A 2 4
MIRT463465 ZC3HAV1L zinc finger CCCH-type containing, antiviral 1 like 2 2
MIRT463801 XPOT exportin for tRNA 2 2
MIRT464010 WDR26 WD repeat domain 26 2 2
MIRT465302 TRIB1 tribbles pseudokinase 1 2 2
MIRT468837 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT469132 RNF126 ring finger protein 126 2 2
MIRT469244 RHOB ras homolog family member B 2 2
MIRT472414 NCKAP1 NCK associated protein 1 2 2
MIRT472432 NCBP2 nuclear cap binding protein subunit 2 2 2
MIRT472808 MTMR12 myotubularin related protein 12 2 2
MIRT477893 DVL3 dishevelled segment polarity protein 3 2 4
MIRT477963 DPM2 dolichyl-phosphate mannosyltransferase subunit 2, regulatory 2 2
MIRT479258 CHSY1 chondroitin sulfate synthase 1 2 2
MIRT479718 CCNF cyclin F 2 2
MIRT480231 C9orf41 carnosine N-methyltransferase 1 2 2
MIRT482600 ABHD14B abhydrolase domain containing 14B 2 2
MIRT483096 TFPI tissue factor pathway inhibitor 2 2
MIRT484644 TBC1D5 TBC1 domain family member 5 2 4
MIRT488899 CLDND1 claudin domain containing 1 2 2
MIRT491954 VPS52 VPS52, GARP complex subunit 2 2
MIRT496937 LBR lamin B receptor 2 2
MIRT498546 TMEM30B transmembrane protein 30B 2 2
MIRT501778 NRBF2 nuclear receptor binding factor 2 2 6
MIRT516286 DBT dihydrolipoamide branched chain transacylase E2 2 2
MIRT516351 GABPB1 GA binding protein transcription factor beta subunit 1 2 2
MIRT516751 ZNF100 zinc finger protein 100 2 2
MIRT517939 ZNF431 zinc finger protein 431 2 4
MIRT518295 ZNF514 zinc finger protein 514 2 4
MIRT518515 CASP10 caspase 10 2 2
MIRT519017 NOA1 nitric oxide associated 1 2 2
MIRT519171 SCO1 SCO1, cytochrome c oxidase assembly protein 2 2
MIRT519470 SPTLC2 serine palmitoyltransferase long chain base subunit 2 2 2
MIRT521029 SLC30A5 solute carrier family 30 member 5 2 2
MIRT521251 SAMD8 sterile alpha motif domain containing 8 2 2
MIRT521682 PRKAR2A protein kinase cAMP-dependent type II regulatory subunit alpha 2 2
MIRT529386 SKP1 S-phase kinase associated protein 1 2 2
MIRT545507 NAP1L1 nucleosome assembly protein 1 like 1 2 2
MIRT549655 RSL1D1 ribosomal L1 domain containing 1 2 2
MIRT551041 CTSB cathepsin B 2 4
MIRT551441 ZNF490 zinc finger protein 490 2 4
MIRT554778 RHEBP1 RHEB pseudogene 1 2 4
MIRT565793 SEC14L5 SEC14 like lipid binding 5 2 2
MIRT566727 MSL2 MSL complex subunit 2 2 2
MIRT574668 HNRNPDL heterogeneous nuclear ribonucleoprotein D like 2 2
MIRT610128 DENND5B DENN domain containing 5B 2 2
MIRT624919 FBXW2 F-box and WD repeat domain containing 2 2 2
MIRT641830 TRIM71 tripartite motif containing 71 2 2
MIRT662165 IFNAR2 interferon alpha and beta receptor subunit 2 2 2
MIRT667150 NRXN3 neurexin 3 2 2
MIRT689085 ADNP2 ADNP homeobox 2 2 2
MIRT696322 DCAF15 DDB1 and CUL4 associated factor 15 2 2
MIRT699062 SNX4 sorting nexin 4 2 2
MIRT703229 GOLGA1 golgin A1 2 2
MIRT705743 AMD1 adenosylmethionine decarboxylase 1 2 2
MIRT706087 HNRNPU heterogeneous nuclear ribonucleoprotein U 2 2
MIRT709288 MAPK8IP2 mitogen-activated protein kinase 8 interacting protein 2 2 2
MIRT711457 RNF145 ring finger protein 145 2 2
MIRT714708 PPP3CC protein phosphatase 3 catalytic subunit gamma 2 2
MIRT719871 CYP4F11 cytochrome P450 family 4 subfamily F member 11 2 2
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-655 Gefitinib approved 123631 Quantitative real-time PCR lung adenocarcinoma cells 24258346 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-655 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-mir-655 Androstenedione 6128 NSC9563 resistant cell line (MCF-7)
hsa-mir-655 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-655-5p Temozolomide 5394 NSC362856 approved sensitive cell line (U251)
hsa-miR-655-5p Gefitinib 123631 NSC715055 approved sensitive cell line (PC9)
hsa-miR-655-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-655-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

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