miRTarBase - #MIRT395372


—
pre-miRNA Information
pre-miRNA hsa-mir-6769b   
Genomic Coordinates chr1: 206474803 - 206474864
Description Homo sapiens miR-6769b stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-6769b-3p
Sequence 42| CCCUCUCUGUCCCACCCAUAG |62
Evidence Experimental
Experiments Meta-analysis
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSN26671848 9 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs555627187 3 dbSNP
rs782102173 4 dbSNP
rs201952639 7 dbSNP
rs782001154 9 dbSNP
rs1488064450 15 dbSNP
rs782111367 16 dbSNP
rs370859899 18 dbSNP
rs1305197911 19 dbSNP
Putative Targets

Gene Information
Gene Symbol CDC42EP4   
Synonyms BORG4, CEP4, KAIA1777
Description CDC42 effector protein 4
Transcript NM_012121   
Expression
Putative miRNA Targets on CDC42EP4
3'UTR of CDC42EP4
(miRNA target sites are highlighted)		 
>CDC42EP4|NM_012121|3'UTR
   1 GGCGGACAGTGGGTGGCCACCGGGAGCTCTTGGCTGCATCTTCTCCCTGCCCCCACCCCACTATGACCTTTGACCCTACG
  81 GCGCAGGGGCAGCCAGGACCCTTGATTCAGACCATGGACCCTGGACCTTGTAGATGAGGGACACTGGCCTGGCCCTCGGG
 161 TCTTCGGAGGACGTAGGGGGCTGGCATGGGTGCCGACTGGCTGCCTGACTTCATCATGCTCCCTGCACTTAGGCTGCGTG
 241 GGACAAGGGCTGTGTTGTCACAGCAGGAATAGGTTTTCCTCTGTTGGCCTCCCTTTCCTCCACCCTGGCCTCAAATGGAT
 321 GCCAGATGCCAACCCCAGTTCTGGCCACGTACAGCCAGCGGGTCAGCCCAGAGGCAGCCTCAGCTCCAGGGCTAAGGACT
 401 CTCGGCTCCCATTTTCTCTGCTGGCGTTTCTGCTGTGCCCAGCAGTGGCTGCTGGGGAAGCAGCTGCAGCAGGAGGGAGA
 481 CGGTCTTGCCTCTCAGCCCCTCCCTGCCCCACCCCAGCTCCTGCCCTGGAAATCTGGAGCCCCTTGGAGCTGAGCTGGAC
 561 GGGGGGCCAGCTGCGAGCATGTGCACTAAACGCAGCCCTTTCCAGGGGAAGAGAACAGGATGGAGAATGGAAGGAAAGCC
 641 CCCCAGGCTTCGTGAATTGCAAGAAGGGACCCTTCCAGGATGACACTAGGAACAGGGCTAGGGCACTCGCTCAGTCCCTA
 721 GGGGCTTGTTTGTTCTTTATTATTGTGTTTAAATCCTTATAGAGCAATATCAGGATGGTGTTAATAGGTCTGCCTCAGAA
 801 TGAGAATCAATCCTTTTAGAAAACCTTTATACTAAGCCTCCTCTTCAAAATTCACAGTGGCGATTAGCGGACTGGAGTCT
 881 GGTGGCGATTAGCGGACTGGAGTCTGGGGACATCCGTGGCAAAGACACCAGCTCAACTTTAGTGCTTCCCAACTTTATTT
 961 AGAATGACATGGGGTGGGTGTCTGGTGTGTGTGTTTTCCCTACGCACCTCCCATAGCTATTAACAACTGAGGAAGGCCAG
1041 TGCAGAATATTTTTGGAGAACGATTTTTTTTTTAAATAATATATCATTCCTATGGGGGGAAAGCCTTTTTTTTCTTTTTG
1121 GCTGAGTTATTCCCTCCCTCCCCTCAATACCCTCAGTACTGACTACTTCCCTTTCTTTTCTCAGGCCTCCCCCCACCGAC
1201 TTTTGAGGCCAGGGTTGGCCAGATTTAGCAAAACCAAAACAGAGTGCTGAGTTAAACGCAAATTTCAGGTAAACAAAAGA
1281 TAATTTTCTAGCATTAATATGCCCCACGCAATATTTGGAACACTTATGTGAAAAATGATTTGTTTTTCTGAAATTCACGT
1361 TTCTCTCTGAGTCCTGTAACTGTCCCCGAGGGGATTGAGCAGAAGCTCGGGTATGAGCCCTGAGGTTGACTGCCGGTTAT
1441 TTTTCTGTCCTGGGAACAGCCTGACCCACCTCCCTGTCTCCATGTAGCCAGTGAGGGGAGGGGGAGACACAGAACCAACC
1521 ACAGCCAGGGGCGTCCCCATGGCGACTGTGGCCCGGCCCCTCCTCTCTTGCCTGACTCTCCTCTCTTGCCTGACTCTAGA
1601 CACTAACTTAGTTCCAGGTTCGGTGCCCTGTTGGTGCTCCTGTTTCCAATAGCTTAGGTCCCATGGTGGGGGAGGAACCT
1681 CAGGGGCTATGCAGCCCCCGCCAGCTGCCCTCGAATCCCGTCCAGGCCAATTCCAGATTCTAAACTGATTTTTTTCATGA
1761 TATTGTCAAAACAGTGAGGAAACATTAAAAAAAAAGCCCTAAAGCAAAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gauaccCACCCUGUCUCUCCc 5'
                ||| |: :|||:|| 
Target 5' tagccaGTGAGG-GGAGGGGg 3'
 1485 - 1504 118.00 -17.70
2 
miRNA  3' gauacccacccUGUCUCUCCc 5'
                     |||| |||| 
Target 5' atattgtcaaaACAGTGAGGa 3'
 1760 - 1780 118.00 -9.80
3 
miRNA  3' gaUACCCACCCUGUCUCUCCc 5'
            || ||||    :|:|||| 
Target 5' ccAT-GGTG----GGGGAGGa 3'
 1661 - 1676 116.00 -16.30
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN13744272 3 COSMIC
COSN31482668 9 COSMIC
COSN30452209 13 COSMIC
COSN30191387 36 COSMIC
COSN30473480 54 COSMIC
COSN31604660 57 COSMIC
COSN30499469 79 COSMIC
COSN30103110 87 COSMIC
COSN31506224 96 COSMIC
COSN30168208 212 COSMIC
COSN20114375 472 COSMIC
COSN7445067 850 COSMIC
COSN5420381 1180 COSMIC
COSN7445066 1282 COSMIC
COSN17181786 1286 COSMIC
COSN1728391 1531 COSMIC
COSN22270228 1619 COSMIC
COSN5180350 1673 COSMIC
COSN15609617 1725 COSMIC
COSN15609261 1729 COSMIC
COSN21948552 1759 COSMIC
COSN20114374 1786 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs199944650 3 dbSNP
rs374087576 4 dbSNP
rs1306655946 6 dbSNP
rs1241832983 9 dbSNP
rs777192035 13 dbSNP
rs768962013 19 dbSNP
rs78835784 20 dbSNP
rs780298868 21 dbSNP
rs772315493 22 dbSNP
rs746046069 23 dbSNP
rs1027425381 24 dbSNP
rs1417016197 27 dbSNP
rs778981650 28 dbSNP
rs774516827 31 dbSNP
rs1470631862 32 dbSNP
rs974006017 33 dbSNP
rs757350645 34 dbSNP
rs748089447 38 dbSNP
rs746101899 41 dbSNP
rs961603114 46 dbSNP
rs1270269878 50 dbSNP
rs1015411234 54 dbSNP
rs1316444471 56 dbSNP
rs1303589996 57 dbSNP
rs186652181 60 dbSNP
rs1394598193 61 dbSNP
rs560665447 69 dbSNP
rs34695520 77 dbSNP
rs545541901 78 dbSNP
rs936493465 79 dbSNP
rs1028067750 80 dbSNP
rs997038607 82 dbSNP
rs774170801 83 dbSNP
rs1237707273 86 dbSNP
rs970591327 87 dbSNP
rs1024868001 90 dbSNP
rs1256181415 90 dbSNP
rs1198491461 97 dbSNP
rs1483340156 100 dbSNP
rs1184336575 104 dbSNP
rs1249550006 108 dbSNP
rs1418515375 109 dbSNP
rs1369706224 112 dbSNP
rs533524183 114 dbSNP
rs537503059 118 dbSNP
rs1011808095 119 dbSNP
rs892049996 121 dbSNP
rs1053181764 125 dbSNP
rs938847588 128 dbSNP
rs928848590 136 dbSNP
rs1044469773 139 dbSNP
rs1371620385 139 dbSNP
rs948846707 140 dbSNP
rs1390264815 143 dbSNP
rs1301420586 148 dbSNP
rs1313559093 149 dbSNP
rs1377253014 153 dbSNP
rs1006347387 154 dbSNP
rs544917275 157 dbSNP
rs866900887 158 dbSNP
rs961276995 165 dbSNP
rs1480294620 166 dbSNP
rs908464763 172 dbSNP
rs1026511743 173 dbSNP
rs1426568361 175 dbSNP
rs986749333 177 dbSNP
rs1181953102 181 dbSNP
rs997696932 181 dbSNP
rs1178582287 182 dbSNP
rs1167122447 189 dbSNP
rs1456786214 192 dbSNP
rs1354442200 194 dbSNP
rs1240448877 195 dbSNP
rs902071183 201 dbSNP
rs1369180617 202 dbSNP
rs1438097997 203 dbSNP
rs1199629597 206 dbSNP
rs3751928 217 dbSNP
rs1028182483 218 dbSNP
rs1230283871 218 dbSNP
rs1306840701 227 dbSNP
rs1222286114 234 dbSNP
rs1255034197 235 dbSNP
rs1230518786 237 dbSNP
rs1213178632 238 dbSNP
rs762623871 243 dbSNP
rs1313442135 249 dbSNP
rs889494690 251 dbSNP
rs1239367296 254 dbSNP
rs1053942871 255 dbSNP
rs1424891411 267 dbSNP
rs1311240064 273 dbSNP
rs113278799 283 dbSNP
rs923706043 289 dbSNP
rs1459381457 293 dbSNP
rs1324665316 295 dbSNP
rs1021924030 296 dbSNP
rs1009655820 297 dbSNP
rs892166701 314 dbSNP
rs1053299701 328 dbSNP
rs1268181293 334 dbSNP
rs1003105270 339 dbSNP
rs542632086 341 dbSNP
rs1228676203 342 dbSNP
rs949225971 344 dbSNP
rs917801594 345 dbSNP
rs1044973030 348 dbSNP
rs1376165661 349 dbSNP
rs1466419843 349 dbSNP
rs1213989756 353 dbSNP
rs553679092 357 dbSNP
rs990787979 359 dbSNP
rs533925261 360 dbSNP
rs1416270431 366 dbSNP
rs570990271 366 dbSNP
rs1163572217 370 dbSNP
rs1412137082 378 dbSNP
rs909236400 382 dbSNP
rs1315703232 384 dbSNP
rs1344270282 397 dbSNP
rs1438428088 403 dbSNP
rs114823049 404 dbSNP
rs939993278 416 dbSNP
rs908583324 425 dbSNP
rs538357553 426 dbSNP
rs1222149084 433 dbSNP
rs955302966 437 dbSNP
rs1313023729 440 dbSNP
rs1212663870 451 dbSNP
rs1026418477 452 dbSNP
rs374738366 455 dbSNP
rs975655774 464 dbSNP
rs1484003252 469 dbSNP
rs1280464108 472 dbSNP
rs3842668 474 dbSNP
rs397841809 474 dbSNP
rs1351484709 480 dbSNP
rs967790132 481 dbSNP
rs1022456898 482 dbSNP
rs1373461263 484 dbSNP
rs1007849234 485 dbSNP
rs1009359839 489 dbSNP
rs1310251018 490 dbSNP
rs1308490589 498 dbSNP
rs1398036730 500 dbSNP
rs1356302678 506 dbSNP
rs74721892 513 dbSNP
rs555989526 515 dbSNP
rs889437840 516 dbSNP
rs1053428635 517 dbSNP
rs1368539000 519 dbSNP
rs537741280 534 dbSNP
rs765964331 537 dbSNP
rs1003052894 540 dbSNP
rs1206352229 542 dbSNP
rs796328573 543 dbSNP
rs907481183 547 dbSNP
rs1023093347 548 dbSNP
rs1190006606 549 dbSNP
rs1425234022 555 dbSNP
rs1478144804 558 dbSNP
rs1013507688 560 dbSNP
rs72851026 561 dbSNP
rs949216193 563 dbSNP
rs368574722 567 dbSNP
rs548951966 567 dbSNP
rs1487020497 574 dbSNP
rs1055435753 575 dbSNP
rs1350479846 580 dbSNP
rs937969198 585 dbSNP
rs1038858427 591 dbSNP
rs940111004 597 dbSNP
rs1229567898 602 dbSNP
rs1300314743 604 dbSNP
rs2345288 615 dbSNP
rs1195787679 618 dbSNP
rs1051108352 620 dbSNP
rs1246686918 637 dbSNP
rs1335800682 639 dbSNP
rs919307526 642 dbSNP
rs1453475348 643 dbSNP
rs771968645 645 dbSNP
rs921189159 651 dbSNP
rs112485141 652 dbSNP
rs1167184875 656 dbSNP
rs566769376 667 dbSNP
rs1319004077 684 dbSNP
rs1008154034 685 dbSNP
rs551851422 688 dbSNP
rs1320679442 692 dbSNP
rs748102426 700 dbSNP
rs987839347 708 dbSNP
rs533510232 709 dbSNP
rs956470214 710 dbSNP
rs143211251 711 dbSNP
rs896308012 712 dbSNP
rs1462283076 713 dbSNP
rs1418210754 716 dbSNP
rs774372865 718 dbSNP
rs1445021859 720 dbSNP
rs35392816 725 dbSNP
rs1192246999 726 dbSNP
rs1368955947 743 dbSNP
rs1169524523 751 dbSNP
rs937858418 760 dbSNP
rs909089644 761 dbSNP
rs981743868 766 dbSNP
rs79036680 767 dbSNP
rs1457839823 771 dbSNP
rs1451015005 777 dbSNP
rs1160453628 786 dbSNP
rs929282993 792 dbSNP
rs1381968747 800 dbSNP
rs1335318225 804 dbSNP
rs1265167738 808 dbSNP
rs1023628157 810 dbSNP
rs1333456728 813 dbSNP
rs139197978 813 dbSNP
rs1262086160 816 dbSNP
rs1348153704 820 dbSNP
rs976146584 822 dbSNP
rs551387225 825 dbSNP
rs1256669348 828 dbSNP
rs1486608885 831 dbSNP
rs745903590 839 dbSNP
rs1256734499 844 dbSNP
rs12795 847 dbSNP
rs1017130622 859 dbSNP
rs78222902 861 dbSNP
rs887194297 862 dbSNP
rs80102328 863 dbSNP
rs1051061544 868 dbSNP
rs562375128 869 dbSNP
rs772867322 869 dbSNP
rs957781788 881 dbSNP
rs1033259159 882 dbSNP
rs1270890613 883 dbSNP
rs977684781 886 dbSNP
rs933971661 887 dbSNP
rs540583862 890 dbSNP
rs1237964446 893 dbSNP
rs1013215461 894 dbSNP
rs1040010592 896 dbSNP
rs1208493005 905 dbSNP
rs114445312 906 dbSNP
rs1179000669 908 dbSNP
rs1483363431 908 dbSNP
rs1248577151 911 dbSNP
rs184178631 915 dbSNP
rs547652977 916 dbSNP
rs1307717665 917 dbSNP
rs935040018 918 dbSNP
rs1397146098 926 dbSNP
rs193055416 928 dbSNP
rs1452921535 929 dbSNP
rs1463769480 934 dbSNP
rs1371694567 939 dbSNP
rs927724435 940 dbSNP
rs146782509 952 dbSNP
rs1299381393 973 dbSNP
rs1477406195 977 dbSNP
rs969454972 978 dbSNP
rs1393608803 987 dbSNP
rs1023322670 993 dbSNP
rs1303624363 995 dbSNP
rs992137716 1002 dbSNP
rs963005574 1003 dbSNP
rs1017090407 1004 dbSNP
rs1307989575 1005 dbSNP
rs772685802 1007 dbSNP
rs1249544790 1028 dbSNP
rs1480323952 1028 dbSNP
rs1004392952 1033 dbSNP
rs1214435374 1037 dbSNP
rs746386421 1057 dbSNP
rs538073228 1061 dbSNP
rs747375745 1062 dbSNP
rs1459301272 1069 dbSNP
rs188839672 1073 dbSNP
rs1372604531 1074 dbSNP
rs910603963 1074 dbSNP
rs986655335 1074 dbSNP
rs998294693 1074 dbSNP
rs1200010346 1077 dbSNP
rs1396192144 1077 dbSNP
rs1324964459 1082 dbSNP
rs936182272 1082 dbSNP
rs1216119263 1083 dbSNP
rs977632376 1092 dbSNP
rs1233956126 1093 dbSNP
rs1275193078 1094 dbSNP
rs183385327 1095 dbSNP
rs758888836 1097 dbSNP
rs1213229097 1104 dbSNP
rs1242928728 1105 dbSNP
rs1487025789 1112 dbSNP
rs1261601339 1114 dbSNP
rs967572106 1114 dbSNP
rs1475847739 1115 dbSNP
rs1276632209 1120 dbSNP
rs1235701673 1121 dbSNP
rs1376769233 1122 dbSNP
rs1307591397 1124 dbSNP
rs1039723417 1140 dbSNP
rs1011218187 1143 dbSNP
rs1163684921 1149 dbSNP
rs533846406 1151 dbSNP
rs960659174 1152 dbSNP
rs879751904 1154 dbSNP
rs1286954225 1156 dbSNP
rs1329123335 1167 dbSNP
rs1052183397 1175 dbSNP
rs1415396085 1176 dbSNP
rs1399459897 1179 dbSNP
rs1174926026 1182 dbSNP
rs1232776505 1182 dbSNP
rs1285168180 1189 dbSNP
rs566867135 1191 dbSNP
rs1454689805 1192 dbSNP
rs1486280531 1193 dbSNP
rs935156145 1194 dbSNP
rs887599787 1197 dbSNP
rs1027517741 1198 dbSNP
rs1471039504 1205 dbSNP
rs149155753 1209 dbSNP
rs1408243556 1210 dbSNP
rs1046110910 1214 dbSNP
rs947857962 1219 dbSNP
rs1156667221 1222 dbSNP
rs1344316962 1225 dbSNP
rs897706741 1226 dbSNP
rs1353517162 1228 dbSNP
rs1414212977 1245 dbSNP
rs1280261526 1254 dbSNP
rs527807422 1257 dbSNP
rs1222346547 1258 dbSNP
rs1209700498 1263 dbSNP
rs1283829491 1270 dbSNP
rs1348972925 1271 dbSNP
rs1040324064 1274 dbSNP
rs1165391869 1279 dbSNP
rs563257230 1282 dbSNP
rs973110648 1283 dbSNP
rs1485661854 1286 dbSNP
rs138231455 1298 dbSNP
rs1208803784 1299 dbSNP
rs543284776 1302 dbSNP
rs1211657420 1303 dbSNP
rs1470882490 1305 dbSNP
rs569400426 1307 dbSNP
rs1379326385 1308 dbSNP
rs963254432 1323 dbSNP
rs1454521109 1324 dbSNP
rs1284497705 1327 dbSNP
rs1413894400 1327 dbSNP
rs1329617246 1331 dbSNP
rs1356283083 1342 dbSNP
rs1071577 1356 dbSNP
rs1374520517 1358 dbSNP
rs1283917651 1359 dbSNP
rs936114473 1367 dbSNP
rs1236932728 1369 dbSNP
rs1301775319 1374 dbSNP
rs983070578 1376 dbSNP
rs529454026 1379 dbSNP
rs878933900 1383 dbSNP
rs951507602 1386 dbSNP
rs1029867350 1387 dbSNP
rs1314231205 1388 dbSNP
rs545430530 1392 dbSNP
rs1359901266 1395 dbSNP
rs964181140 1399 dbSNP
rs1018654646 1408 dbSNP
rs1237158728 1408 dbSNP
rs576459506 1409 dbSNP
rs1402316082 1411 dbSNP
rs573408812 1413 dbSNP
rs560876853 1417 dbSNP
rs1408234725 1424 dbSNP
rs1181029455 1433 dbSNP
rs1010913693 1434 dbSNP
rs1259854913 1435 dbSNP
rs1443472125 1436 dbSNP
rs1188827321 1448 dbSNP
rs1370644987 1450 dbSNP
rs1488004266 1454 dbSNP
rs893841588 1469 dbSNP
rs1218583441 1476 dbSNP
rs1338061449 1478 dbSNP
rs1256932151 1482 dbSNP
rs1318004751 1493 dbSNP
rs1042988 1494 dbSNP
rs1104813 1498 dbSNP
rs1450771128 1499 dbSNP
rs906363094 1500 dbSNP
rs1193666392 1501 dbSNP
rs6905 1517 dbSNP
rs980533346 1518 dbSNP
rs114858544 1519 dbSNP
rs544641342 1521 dbSNP
rs947770826 1522 dbSNP
rs1414947159 1526 dbSNP
rs555130813 1527 dbSNP
rs1339296721 1531 dbSNP
rs916335007 1532 dbSNP
rs1037891363 1533 dbSNP
rs1345684616 1536 dbSNP
rs961907114 1539 dbSNP
rs78523747 1543 dbSNP
rs1403384165 1544 dbSNP
rs191666399 1552 dbSNP
rs543988631 1554 dbSNP
rs1050831104 1555 dbSNP
rs1355473318 1555 dbSNP
rs951624722 1558 dbSNP
rs922743721 1563 dbSNP
rs140467356 1565 dbSNP
rs1421613178 1572 dbSNP
rs1445075497 1576 dbSNP
rs1192782713 1581 dbSNP
rs1041793570 1582 dbSNP
rs1476205070 1588 dbSNP
rs1491095479 1598 dbSNP
rs373366780 1599 dbSNP
rs1454554284 1605 dbSNP
rs1246627343 1609 dbSNP
rs917456443 1611 dbSNP
rs964443475 1615 dbSNP
rs1057297898 1621 dbSNP
rs1018350267 1622 dbSNP
rs1416054642 1626 dbSNP
rs1310014206 1627 dbSNP
rs990008535 1630 dbSNP
rs958012423 1633 dbSNP
rs376260208 1640 dbSNP
rs927581785 1645 dbSNP
rs1351176339 1649 dbSNP
rs1215669128 1652 dbSNP
rs760368160 1659 dbSNP
rs906477625 1662 dbSNP
rs1025189867 1663 dbSNP
rs373346345 1668 dbSNP
rs895011801 1671 dbSNP
rs1292876452 1677 dbSNP
rs1362299946 1679 dbSNP
rs555318889 1681 dbSNP
rs1174700089 1688 dbSNP
rs1377771283 1692 dbSNP
rs1362653913 1695 dbSNP
rs1302783412 1696 dbSNP
rs941805544 1699 dbSNP
rs1391489916 1701 dbSNP
rs886079674 1704 dbSNP
rs185481612 1712 dbSNP
rs536 1713 dbSNP
rs558162103 1719 dbSNP
rs922859794 1720 dbSNP
rs3841 1730 dbSNP
rs904567926 1736 dbSNP
rs1043064 1740 dbSNP
rs11551234 1742 dbSNP
rs1465336937 1747 dbSNP
rs1480972065 1749 dbSNP
rs1197658780 1763 dbSNP
rs1248646506 1773 dbSNP
rs1457520655 1780 dbSNP
rs1010301276 1787 dbSNP
rs397695304 1787 dbSNP
rs1491083416 1796 dbSNP
rs34121296 1796 dbSNP
rs371922952 1796 dbSNP
rs746180170 1796 dbSNP
rs796067666 1796 dbSNP
rs942877299 1801 dbSNP
rs1397659414 1804 dbSNP
rs1057476593 1807 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HeLa
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in Chi_124B_2A8_130_50. RNA binding protein: AGO. Condition:HeLa cell miR-124 + B ...

- Chi SW; Zang JB; Mele A; Darnell RB, 2009, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gauacccaCCCUGUCUCUCcc 5'
                  |||| :|||||  
Target 5' --------GGGA-GGAGAGcu 3'
 		1 - 12
Article - Chi SW; Zang JB; Mele A; Darnell RB
- Nature, 2009
MicroRNAs (miRNAs) have critical roles in the regulation of gene expression; however, as miRNA activity requires base pairing with only 6-8 nucleotides of messenger RNA, predicting target mRNAs is a major challenge. Recently, high-throughput sequencing of RNAs isolated by crosslinking immunoprecipitation (HITS-CLIP) has identified functional protein-RNA interaction sites. Here we use HITS-CLIP to covalently crosslink native argonaute (Ago, also called Eif2c) protein-RNA complexes in mouse brain. This produced two simultaneous data sets-Ago-miRNA and Ago-mRNA binding sites-that were combined with bioinformatic analysis to identify interaction sites between miRNA and target mRNA. We validated genome-wide interaction maps for miR-124, and generated additional maps for the 20 most abundant miRNAs present in P13 mouse brain. Ago HITS-CLIP provides a general platform for exploring the specificity and range of miRNA action in vivo, and identifies precise sequences for targeting clinically relevant miRNA-mRNA interactions.
LinkOut: [PMID: 19536157]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions HEK293S
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... HITS-CLIP data was present in GSM1084065. RNA binding protein: AGO2. Condition:CLIP_emetine_AbnovaAb HITS-CLIP data was present in GSM1084079. RNA binding protein: AGO2. Condition:CLIP_hippuristanol_rep2_AbnovaAb ...

- Karginov FV; Hannon GJ, 2013, Genes & development.

Article - Karginov FV; Hannon GJ
- Genes & development, 2013
When adapting to environmental stress, cells attenuate and reprogram their translational output. In part, these altered translation profiles are established through changes in the interactions between RNA-binding proteins and mRNAs. The Argonaute 2 (Ago2)/microRNA (miRNA) machinery has been shown to participate in stress-induced translational up-regulation of a particular mRNA, CAT-1; however, a detailed, transcriptome-wide understanding of the involvement of Ago2 in the process has been lacking. Here, we profiled the overall changes in Ago2-mRNA interactions upon arsenite stress by cross-linking immunoprecipitation (CLIP) followed by high-throughput sequencing (CLIP-seq). Ago2 displayed a significant remodeling of its transcript occupancy, with the majority of 3' untranslated region (UTR) and coding sequence (CDS) sites exhibiting stronger interaction. Interestingly, target sites that were destined for release from Ago2 upon stress were depleted in miRNA complementarity signatures, suggesting an alternative mode of interaction. To compare the changes in Ago2-binding patterns across transcripts with changes in their translational states, we measured mRNA profiles on ribosome/polysome gradients by RNA sequencing (RNA-seq). Increased Ago2 occupancy correlated with stronger repression of translation for those mRNAs, as evidenced by a shift toward lighter gradient fractions upon stress, while release of Ago2 was associated with the limited number of transcripts that remained translated. Taken together, these data point to a role for Ago2 and the mammalian miRNAs in mediating the translational component of the stress response.
LinkOut: [PMID: 23824327]
CLIP-seq Support 1 for dataset Chi_124B_2A8_130_50
Method / RBP HITS-CLIP / AGO
Cell line / Condition HeLa / HeLa cell miR-124 + B
Location of target site ENST00000335793.3 | 3UTR | GGGAGGAGAGCUGGGG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 19536157 / Chi_HITSCLIP
CLIP-seq Viewer Link
CLIP-seq Support 2 for dataset GSM1084065
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_emetine_AbnovaAb
Location of target site ENST00000335793.3 | 3UTR | CCAAGGGAAGAAGAGAGAGGGAGGAGAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
CLIP-seq Support 3 for dataset GSM1084079
Method / RBP HITS-CLIP / AGO2
Cell line / Condition HEK293S / CLIP_hippuristanol_rep2_AbnovaAb
Location of target site ENST00000335793.3 | 3UTR | AGAAGAGAGAGGGAGGAGAGC
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23824327 / GSE44404
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
209 hsa-miR-6769b-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT181753 UHMK1 U2AF homology motif kinase 1 2 2
MIRT287119 SMARCE1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1 2 2
MIRT395372 CDC42EP4 CDC42 effector protein 4 2 4
MIRT472533 NACC1 nucleus accumbens associated 1 2 4
MIRT472611 NAA50 N(alpha)-acetyltransferase 50, NatE catalytic subunit 2 2
MIRT482405 ADRB1 adrenoceptor beta 1 2 10
MIRT492330 SETD1B SET domain containing 1B 2 2
MIRT499238 VAV3 vav guanine nucleotide exchange factor 3 2 6
MIRT512274 ARHGDIA Rho GDP dissociation inhibitor alpha 2 6
MIRT534548 RUNX1 runt related transcription factor 1 2 2
MIRT535374 PEX5L peroxisomal biogenesis factor 5 like 2 2
MIRT535424 PDZD8 PDZ domain containing 8 2 2
MIRT539329 AHSA2 activator of HSP90 ATPase homolog 2 2 4
MIRT569350 EFHC1 EF-hand domain containing 1 2 2
MIRT576116 Klf6 Kruppel-like factor 6 2 2
MIRT607241 LINS lines homolog 1 2 4
MIRT607364 ASAH2 N-acylsphingosine amidohydrolase 2 2 4
MIRT609572 CATSPER4 cation channel sperm associated 4 2 2
MIRT610045 SERPINA3 serpin family A member 3 2 2
MIRT610284 PLCXD3 phosphatidylinositol specific phospholipase C X domain containing 3 2 2
MIRT610302 KLHL21 kelch like family member 21 2 2
MIRT610393 FOXE1 forkhead box E1 2 2
MIRT610432 ASAH2B N-acylsphingosine amidohydrolase 2B 2 2
MIRT610510 BARHL2 BarH like homeobox 2 2 2
MIRT611818 FCRL4 Fc receptor like 4 2 2
MIRT612755 MYOCD myocardin 2 2
MIRT613698 QPRT quinolinate phosphoribosyltransferase 2 2
MIRT613917 POU3F1 POU class 3 homeobox 1 2 2
MIRT615153 URGCP-MRPS24 URGCP-MRPS24 readthrough 2 2
MIRT615201 CLUAP1 clusterin associated protein 1 2 2
MIRT615338 ABCC12 ATP binding cassette subfamily C member 12 2 2
MIRT616706 UBXN2A UBX domain protein 2A 2 2
MIRT617186 GOSR2 golgi SNAP receptor complex member 2 2 4
MIRT617526 SORCS2 sortilin related VPS10 domain containing receptor 2 2 2
MIRT617596 NUDT5 nudix hydrolase 5 2 4
MIRT617763 C17orf105 chromosome 17 open reading frame 105 2 2
MIRT618613 SHOX short stature homeobox 2 2
MIRT619301 FAM26E calcium homeostasis modulator family member 5 2 2
MIRT619515 TXLNB taxilin beta 2 2
MIRT619925 NLRP9 NLR family pyrin domain containing 9 2 2
MIRT619942 C8orf33 chromosome 8 open reading frame 33 2 2
MIRT620025 NFAM1 NFAT activating protein with ITAM motif 1 2 2
MIRT620554 C10orf10 chromosome 10 open reading frame 10 2 4
MIRT620752 CCR5 C-C motif chemokine receptor 5 (gene/pseudogene) 2 2
MIRT621798 TMEM233 transmembrane protein 233 2 2
MIRT621843 TGFBR3 transforming growth factor beta receptor 3 2 2
MIRT622693 PLSCR1 phospholipid scramblase 1 2 2
MIRT622733 PITPNM3 PITPNM family member 3 2 2
MIRT623004 ONECUT3 one cut homeobox 3 2 2
MIRT623211 MTFR1L mitochondrial fission regulator 1 like 2 2
MIRT623771 GPR37L1 G protein-coupled receptor 37 like 1 2 2
MIRT624119 DNAH10OS dynein axonemal heavy chain 10 opposite strand 2 2
MIRT624150 DIAPH1 diaphanous related formin 1 2 2
MIRT624443 CAMK2N1 calcium/calmodulin dependent protein kinase II inhibitor 1 2 2
MIRT624855 ABI2 abl interactor 2 2 2
MIRT625311 SHISA6 shisa family member 6 2 2
MIRT625741 MTSS1 MTSS1, I-BAR domain containing 2 2
MIRT626292 ZNF85 zinc finger protein 85 2 2
MIRT627400 TMEM170A transmembrane protein 170A 2 2
MIRT627464 SYNRG synergin gamma 2 2
MIRT627913 KANSL1 KAT8 regulatory NSL complex subunit 1 2 2
MIRT636508 GDAP1L1 ganglioside induced differentiation associated protein 1 like 1 2 2
MIRT636910 KIAA0408 KIAA0408 2 2
MIRT637302 ACTN2 actinin alpha 2 2 2
MIRT638230 SOGA3 SOGA family member 3 2 2
MIRT639880 STC1 stanniocalcin 1 2 2
MIRT639999 PHF21B PHD finger protein 21B 2 2
MIRT640149 CEP104 centrosomal protein 104 2 2
MIRT640699 SKI SKI proto-oncogene 2 2
MIRT640911 RAB13 RAB13, member RAS oncogene family 2 2
MIRT641518 CREBBP CREB binding protein 2 2
MIRT641990 OXSR1 oxidative stress responsive 1 2 2
MIRT642635 EPPIN epididymal peptidase inhibitor 2 2
MIRT642744 TDRD6 tudor domain containing 6 2 2
MIRT642759 SDHAF2 succinate dehydrogenase complex assembly factor 2 2 2
MIRT642787 CHCHD3 coiled-coil-helix-coiled-coil-helix domain containing 3 2 2
MIRT643054 EPPIN-WFDC6 EPPIN-WFDC6 readthrough 2 2
MIRT643104 NDUFB5 NADH:ubiquinone oxidoreductase subunit B5 2 2
MIRT643316 TMEM151B transmembrane protein 151B 2 2
MIRT643715 ITK IL2 inducible T-cell kinase 2 2
MIRT644087 A4GALT alpha 1,4-galactosyltransferase (P blood group) 2 2
MIRT644112 SEL1L3 SEL1L family member 3 2 2
MIRT644377 ZNF286A zinc finger protein 286A 2 2
MIRT644408 FRMD6 FERM domain containing 6 2 2
MIRT644684 TMCO1 transmembrane and coiled-coil domains 1 2 2
MIRT644744 CCDC174 coiled-coil domain containing 174 2 2
MIRT644876 C2orf48 chromosome 2 open reading frame 48 2 2
MIRT645417 FAM110A family with sequence similarity 110 member A 2 2
MIRT645928 PLXNA3 plexin A3 2 2
MIRT646181 PTPN14 protein tyrosine phosphatase, non-receptor type 14 2 2
MIRT646554 TMCC2 transmembrane and coiled-coil domain family 2 2 2
MIRT647235 OR6A2 olfactory receptor family 6 subfamily A member 2 2 2
MIRT647263 PTGDR2 prostaglandin D2 receptor 2 2 2
MIRT647660 FOXL1 forkhead box L1 2 2
MIRT648284 TRAPPC2L trafficking protein particle complex 2 like 2 2
MIRT648493 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT648963 TMEM45B transmembrane protein 45B 2 2
MIRT649511 RAB17 RAB17, member RAS oncogene family 2 2
MIRT650446 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT650712 KRT32 keratin 32 2 2
MIRT651069 ZNF518B zinc finger protein 518B 2 4
MIRT651090 ZNF516 zinc finger protein 516 2 2
MIRT651193 ZNF281 zinc finger protein 281 2 2
MIRT651330 ZCCHC2 zinc finger CCHC-type containing 2 2 2
MIRT651445 XKR4 XK related 4 2 2
MIRT651517 WNT4 Wnt family member 4 2 4
MIRT651694 VPS13D vacuolar protein sorting 13 homolog D 2 2
MIRT652173 TRIM66 tripartite motif containing 66 2 2
MIRT652432 TMEM239 transmembrane protein 239 2 2
MIRT652656 TIMM10 translocase of inner mitochondrial membrane 10 2 2
MIRT652707 THBS2 thrombospondin 2 2 2
MIRT652812 TBL2 transducin beta like 2 2 2
MIRT653350 SMG7 SMG7, nonsense mediated mRNA decay factor 2 2
MIRT653471 SLC4A1 solute carrier family 4 member 1 (Diego blood group) 2 2
MIRT653658 SLC27A4 solute carrier family 27 member 4 2 2
MIRT654691 PSMB5 proteasome subunit beta 5 2 2
MIRT654735 PRLR prolactin receptor 2 2
MIRT654931 POLR3D RNA polymerase III subunit D 2 2
MIRT655209 PHAX phosphorylated adaptor for RNA export 2 2
MIRT655346 PCP4L1 Purkinje cell protein 4 like 1 2 2
MIRT655404 PANK1 pantothenate kinase 1 2 2
MIRT655482 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT655964 NDNF neuron derived neurotrophic factor 2 2
MIRT656017 MYPN myopalladin 2 2
MIRT656491 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT657151 ITGA1 integrin subunit alpha 1 2 2
MIRT657411 HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 2 2
MIRT657608 GRID1 glutamate ionotropic receptor delta type subunit 1 2 2
MIRT658181 FBXO9 F-box protein 9 2 2
MIRT658932 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT659028 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT659092 DENR density regulated re-initiation and release factor 2 2
MIRT659204 CYBB cytochrome b-245 beta chain 2 2
MIRT659718 CCDC93 coiled-coil domain containing 93 2 2
MIRT660185 BNC2 basonuclin 2 2 2
MIRT660805 AIFM2 apoptosis inducing factor, mitochondria associated 2 2 2
MIRT660900 ADCY6 adenylate cyclase 6 2 2
MIRT660925 ADAM19 ADAM metallopeptidase domain 19 2 2
MIRT661741 DTHD1 death domain containing 1 2 2
MIRT661998 EFTUD2 elongation factor Tu GTP binding domain containing 2 2 2
MIRT662639 PKHD1L1 PKHD1 like 1 2 2
MIRT664338 RAB8A RAB8A, member RAS oncogene family 2 2
MIRT666743 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT667070 PANK3 pantothenate kinase 3 2 2
MIRT667925 IGLON5 IgLON family member 5 2 2
MIRT668488 ETV3 ETS variant 3 2 2
MIRT668610 EHD4 EH domain containing 4 2 2
MIRT669419 ATP9A ATPase phospholipid transporting 9A (putative) 2 2
MIRT669652 ACSBG1 acyl-CoA synthetase bubblegum family member 1 2 2
MIRT674005 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT680447 SLCO5A1 solute carrier organic anion transporter family member 5A1 2 2
MIRT684326 GTF3C4 general transcription factor IIIC subunit 4 2 2
MIRT685625 C12orf49 chromosome 12 open reading frame 49 2 2
MIRT689978 ZNF185 zinc finger protein 185 with LIM domain 2 2
MIRT693962 HNRNPA1L2 heterogeneous nuclear ribonucleoprotein A1-like 2 2 2
MIRT698543 TFRC transferrin receptor 2 2
MIRT699982 RREB1 ras responsive element binding protein 1 2 2
MIRT702898 HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 2 2
MIRT707383 VCAM1 vascular cell adhesion molecule 1 2 2
MIRT708312 CDH8 cadherin 8 2 2
MIRT708406 GRIN2A glutamate ionotropic receptor NMDA type subunit 2A 2 2
MIRT709299 LDLRAD4 low density lipoprotein receptor class A domain containing 4 2 2
MIRT710326 STK40 serine/threonine kinase 40 2 2
MIRT710729 C19orf68 zinc finger SWIM-type containing 9 2 2
MIRT710970 CMKLR1 chemerin chemokine-like receptor 1 2 2
MIRT711178 EMCN endomucin 2 2
MIRT711590 SETD1A SET domain containing 1A 2 2
MIRT711611 LHX5 LIM homeobox 5 2 2
MIRT711701 GMPR guanosine monophosphate reductase 2 2
MIRT711850 AMOTL2 angiomotin like 2 2 2
MIRT712358 NAT14 N-acetyltransferase 14 (putative) 2 2
MIRT712377 MTPN myotrophin 2 2
MIRT712469 KCNC3 potassium voltage-gated channel subfamily C member 3 2 2
MIRT712839 RHOA ras homolog family member A 2 2
MIRT713592 ANKMY1 ankyrin repeat and MYND domain containing 1 2 2
MIRT713982 ASIC4 acid sensing ion channel subunit family member 4 2 2
MIRT714534 ZBTB39 zinc finger and BTB domain containing 39 2 2
MIRT714570 GALNT10 polypeptide N-acetylgalactosaminyltransferase 10 2 2
MIRT714610 EXO5 exonuclease 5 2 2
MIRT714943 ZNF330 zinc finger protein 330 2 2
MIRT715132 ACADL acyl-CoA dehydrogenase, long chain 2 2
MIRT716018 TMPRSS5 transmembrane protease, serine 5 2 2
MIRT716204 TYW3 tRNA-yW synthesizing protein 3 homolog 2 2
MIRT716674 PPP6R1 protein phosphatase 6 regulatory subunit 1 2 2
MIRT717366 EDN2 endothelin 2 2 2
MIRT718110 CRTC1 CREB regulated transcription coactivator 1 2 2
MIRT718502 GYS1 glycogen synthase 1 2 2
MIRT719146 DPYSL5 dihydropyrimidinase like 5 2 2
MIRT719415 B4GALNT3 beta-1,4-N-acetyl-galactosaminyltransferase 3 2 2
MIRT719986 MAPK1 mitogen-activated protein kinase 1 2 2
MIRT720347 BACE2 beta-site APP-cleaving enzyme 2 2 2
MIRT720452 SLC16A5 solute carrier family 16 member 5 2 2
MIRT720493 TMEM178B transmembrane protein 178B 2 2
MIRT720666 C11orf54 chromosome 11 open reading frame 54 2 2
MIRT721091 CCBE1 collagen and calcium binding EGF domains 1 2 2
MIRT721334 IFNAR2 interferon alpha and beta receptor subunit 2 2 2
MIRT721384 MACC1 MACC1, MET transcriptional regulator 2 2
MIRT721508 CARHSP1 calcium regulated heat stable protein 1 2 2
MIRT721827 POU6F1 POU class 6 homeobox 1 2 2
MIRT722136 TTLL11 tubulin tyrosine ligase like 11 2 2
MIRT723070 GGA1 golgi associated, gamma adaptin ear containing, ARF binding protein 1 2 2
MIRT723115 ZSCAN16 zinc finger and SCAN domain containing 16 2 2
MIRT723374 ZNF470 zinc finger protein 470 2 2
MIRT724446 OPA3 OPA3, outer mitochondrial membrane lipid metabolism regulator 2 2
MIRT724528 ATP2B1 ATPase plasma membrane Ca2+ transporting 1 2 2
MIRT724643 PKDREJ polycystin family receptor for egg jelly 2 2
MIRT724711 CRAMP1L cramped chromatin regulator homolog 1 2 2
MIRT724750 ZNF391 zinc finger protein 391 2 2
MIRT724770 PSG4 pregnancy specific beta-1-glycoprotein 4 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-6769b Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-mir-6769b Docetaxel+Cisplatin+5-Fluorouracil sensitive tissue (hypopharyngeal squamous cell carcinoma)
hsa-miR-6769b-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (PC9)
hsa-miR-6769b-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-6769b-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)

Error report submission