miRTarBase - #MIRT405243


—
pre-miRNA Information
pre-miRNA hsa-mir-4753   
Genomic Coordinates chr1: 235190034 - 235190116
Description Homo sapiens miR-4753 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4753-5p
Sequence 10| CAAGGCCAAAGGAAGAGAACAG |31
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs547986869 3 dbSNP
rs1007787337 7 dbSNP
rs1224263160 12 dbSNP
rs1256249071 13 dbSNP
rs1484015538 14 dbSNP
rs535678819 19 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ADIPOR2   
Synonyms ACDCR2, PAQR2
Description adiponectin receptor 2
Transcript NM_024551   
Expression
Putative miRNA Targets on ADIPOR2
3'UTR of ADIPOR2
(miRNA target sites are highlighted)		 
>ADIPOR2|NM_024551|3'UTR
   1 TACCTACCAGTCTCCAGGGACTATGACCCTAAACCAGGGCCTGCGGCACTTGCGGGCCTCCCTGCTGGCTACTGATGCCA
  81 GTACCAGAGGAGCCCCAAAACTTTGACAGCCTCGTGGGCTTTGTGACGGCCCAGGGGCTCTGCGTGGTACATGACTGAGA
 161 AGAGAAAAACAAAAATAAATCATACCTCAAAGGATGGAGTGCATCAATTGGGAGAAAAGGAGACATAGCCCAAACCCTGG
 241 CTTATTCTTGGGATCTACTGATTGCGGGCTCTGCAAGACCCTTGGCAAACTGGCTTCTGATCCATATCATATTTATTTGT
 321 AGAAGATGGCGAAACAGTTTAGCTGGTGGTTCTTTCTTCTCCCTTTCTCTCTCTCTATGACAATAATACAAACCAATTTA
 401 AGTGAACATTTATATCCGATAAGGGGTGGGAGTGTGATTTTAAATGCTCTTTTGGGAGAACAAAGAAATTAATGTAAATA
 481 AGATTTCTAACTGTTTAAATAAGACTTTATATAAATGTTTAAAACATAGGGGTAAGGGAGGGAGGGAGAATTTTTGTATA
 561 GAATGAAACATGCAAGTACCACACACTGTTTGAATTTTGCACAAAAAGTGACTGTAGGATCAGGTGATAGCCCCGGAATG
 641 TACAGTGTCTTGGTGCACCAAGATGCCTTCTAAAGGCTGACATACCTTGGACCCTAATGGGGCAGAGAGTATAGCCCTAG
 721 CCCAGTGGTGACATGACCACTCCCTTTGGGAGGCCTGAGGTAGAGGGGAGTGGTATGTGTTTTCTCAGTGGAAGCAGCAC
 801 ATGAGTGGGTGACAGGATGTTAGATAAAGGCTCTAGTTAGGGTGTCATTGTCATTTGAGAGACTGACACACTCCTAGCAG
 881 CTGGTAAAGGGGTGCTGGAGGCCATGGAGGAGCTCTAGAAACATTAGCATGGGCTGATCTGATTACTTCCTGGCATCCCG
 961 CTCACTTTTATGGGAAGTCTTATTAGAGGGATGGGACAGTTTTCCATATCCTTGCTGTGGAGCTCTGGAACACTCTCTAA
1041 ATTTCCCTCTATTAAAAATCACTGCCCTAACTACACTTCCTCCTTGAGGGAATAGAAATGGACCTTTCTCTGACATAGTT
1121 CTTGGCATGGGAGCCAGCCACAAATGAGATTCTGACGTGTCCAGGTTTCTCCTGAGCTCATCTACATAGATTGGTAGACC
1201 CTTCCTTTGGATTAGGAAAGATGAGTTTTACCTCTGGTACACTGTCTTGGTAAGCCTGGATGTGACAGACACCTCGGCTC
1281 TCCTTGAATAAGAAAGCCAGCAGAACTCTTAAAGCCAGTTGTAGTACGGAGTTGTCAGCACTCACTGAACCTCACTTTAC
1361 AGGGATAAGAGTGGTGTGGCATTTTAAATACAATGGTATGTTATTGCCAGGGAGTGAGGTACAAGACGATGGCTCATGTC
1441 ACAGGCCTACCTGATACGGTGTCAGAGAAAGTGGTGGGGAAAGGATCTGGTTCATGGAATTCTGATCTTGGCCCATAGGT
1521 GAACCACCAAAATAGTGCTCGAGTCTTAGGTTACTGTCATCAAAGACTTGGGATGACTCCATTATATCCTGGGGTTGTGG
1601 GTATTAGAACTAAATATGGAGGTCCTGAGCATGGGGACTGGCGTCCTCAGTAGGTGTTTGGGAATATGGGAAGGGTCTCC
1681 TATTTATTCAATAGAGTTTTCTCAGTTATTTTCCTCCCTTGCCCTTGCAATCTCCAGCAAAAGGTGGGATCTAGGAAGAA
1761 AGAATCCAGTGTAGAAGTTGAGAAGAACTTGAACGTTTTGGTTCTGGATAAGGTCACTGTCCTAGGTGCTAGGTGGACCG
1841 AGCAAAAGACTCAGTGGATGAACTGGTGCAGTGCCTGACAGAATAAAGAACAGTATTAATCCCTTTGAGAAAGCATAGTC
1921 CAGCAGGACAGTGGCCATTTGGACAGAAGCCCACTTAGTTTCTTGGGAGCAACAGCACGTATCAGAAGCCAGACTTGCTC
2001 TTCGGTCATGCACTTTGGGATACAGCGTATAGGTGCAGCCCTGTCACAACACCAACAGAAGTAGCAGCCTCTGGGTGCAG
2081 TCACCCACACCCCAAAGCTGGAAGGATCTGGTTCAACATAGCACAAACCCTTAGGAAAAATGAAATTAACATCACTGATG
2161 TGTAATCCAGTAAAATCTCCCTTTTTCGGGTGTGTATGTGGGCATGTGCCCATTTCTATGTGTGTGTCTACGTGCAGCTC
2241 ACTACCAACAGCCTCATGTGCACTTGACCTGACAGTGCTCGCTGAGAACTCTCACCAGGTTGGCGCCTGAATGCCTTACT
2321 CTCAGCAGTCAGAGGCTTGCTTGCTCTGTGCAGATTTTTAATTTTCTTTTTTGGCCCTAGGCTGGTTGGGACCTCTACAG
2401 CTTCATTCTTTCACCATTAAATAGTGGCCTTTTTCAGTATTTTCCCTCTTCCCCTTTATAAATTATGCTAAAGCCACAAA
2481 GCACATTTTTGGGGATCATAGAAGGTTGGGGTTCCAGAAAGGCATCTGTGTGATGGTTCCATTGATGTGGGATTTCCCTA
2561 CTTGCTGTATTCTCAGTTTCTAATAAAAAGAACCAAATGAAATATGAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' gacAAGAGA-AGG-AA------ACCGGAAc 5'
             ||||:|  || ||      ||||||| 
Target 5' tcaTTCTTTCACCATTAAATAGTGGCCTTt 3'
 2403 - 2432 149.00 -12.74
2 
miRNA  3' gaCAAGAGAAGGA---AACCGGAAc 5'
            ||| |:|||||   ||| |||| 
Target 5' caGTTATTTTCCTCCCTTGCCCTTg 3'
 1703 - 1727 144.00 -16.50
3 
miRNA  3' gacAAGAGAAGGAAACCGGAAc 5'
             ||:|||| :||||||| | 
Target 5' taaTTTTCTT-TTTTGGCCCTa 3'
 2359 - 2379 142.00 -14.52
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31507916 7 COSMIC
COSN26965267 21 COSMIC
COSN30519551 46 COSMIC
COSN31511050 47 COSMIC
COSN26567298 56 COSMIC
COSN26965268 75 COSMIC
COSN31612061 114 COSMIC
COSN31489491 115 COSMIC
COSN30120742 129 COSMIC
COSN19135763 132 COSMIC
COSN18736902 135 COSMIC
COSN30113858 176 COSMIC
COSN31512972 365 COSMIC
COSN31519711 466 COSMIC
COSN31595394 646 COSMIC
COSN31570436 708 COSMIC
COSN23693688 960 COSMIC
COSN8704424 1126 COSMIC
COSN10102756 1354 COSMIC
COSN16501347 1562 COSMIC
COSN8704429 1571 COSMIC
COSN22942326 1620 COSMIC
COSN31607878 1889 COSMIC
COSN26550593 1970 COSMIC
COSN26563498 2171 COSMIC
COSN21322422 2183 COSMIC
COSN8704434 2217 COSMIC
COSN30173940 2324 COSMIC
COSN5319435 2440 COSMIC
COSN31571383 2481 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs760004494 3 dbSNP
rs1000788514 6 dbSNP
rs770166457 6 dbSNP
rs376869220 8 dbSNP
rs573669927 9 dbSNP
rs761314663 10 dbSNP
rs773664032 10 dbSNP
rs954028523 11 dbSNP
rs1203311284 15 dbSNP
rs1250037017 20 dbSNP
rs1420094459 22 dbSNP
rs376949602 24 dbSNP
rs776821829 26 dbSNP
rs1477990688 28 dbSNP
rs966185927 28 dbSNP
rs761992740 30 dbSNP
rs1376765500 32 dbSNP
rs972002138 43 dbSNP
rs370259217 45 dbSNP
rs372771001 46 dbSNP
rs966453387 48 dbSNP
rs1447105735 49 dbSNP
rs1375982747 51 dbSNP
rs977917933 54 dbSNP
rs1242720201 55 dbSNP
rs187669714 57 dbSNP
rs1411266497 66 dbSNP
rs575883583 79 dbSNP
rs1190572061 83 dbSNP
rs1260189488 85 dbSNP
rs1180596380 88 dbSNP
rs926924415 93 dbSNP
rs781037676 95 dbSNP
rs1206728421 102 dbSNP
rs1461417240 106 dbSNP
rs1320140316 113 dbSNP
rs1289509638 114 dbSNP
rs1232435382 115 dbSNP
rs1355898954 118 dbSNP
rs957957987 119 dbSNP
rs546485052 128 dbSNP
rs190990632 129 dbSNP
rs896216509 132 dbSNP
rs386759488 134 dbSNP
rs879297712 134 dbSNP
rs730032 135 dbSNP
rs758169 136 dbSNP
rs1335863962 142 dbSNP
rs1388884921 144 dbSNP
rs912610359 145 dbSNP
rs1461666707 147 dbSNP
rs1436878703 171 dbSNP
rs940112154 173 dbSNP
rs1037177031 174 dbSNP
rs898642293 180 dbSNP
rs562083599 196 dbSNP
rs1179014391 209 dbSNP
rs1275896036 211 dbSNP
rs1246315025 229 dbSNP
rs1214513636 234 dbSNP
rs1028233061 235 dbSNP
rs1055378806 241 dbSNP
rs1347791576 253 dbSNP
rs1226418468 266 dbSNP
rs1316256640 267 dbSNP
rs1202116112 270 dbSNP
rs895441535 274 dbSNP
rs1013219475 275 dbSNP
rs1392592379 276 dbSNP
rs1364825070 281 dbSNP
rs1024654395 282 dbSNP
rs1008468368 287 dbSNP
rs763649829 294 dbSNP
rs1441107963 296 dbSNP
rs1019449252 298 dbSNP
rs1157398518 302 dbSNP
rs1457100541 304 dbSNP
rs1259728711 307 dbSNP
rs1427926404 313 dbSNP
rs771232113 320 dbSNP
rs187521934 327 dbSNP
rs1199711382 329 dbSNP
rs1462472195 330 dbSNP
rs550730419 331 dbSNP
rs575453647 332 dbSNP
rs1469989125 334 dbSNP
rs1175403132 344 dbSNP
rs1389186086 347 dbSNP
rs368981439 350 dbSNP
rs192753878 354 dbSNP
rs1241033860 357 dbSNP
rs1261122521 357 dbSNP
rs984779341 359 dbSNP
rs1310377243 366 dbSNP
rs774999225 366 dbSNP
rs562864824 372 dbSNP
rs533077487 376 dbSNP
rs551213793 378 dbSNP
rs1386808826 381 dbSNP
rs756977827 384 dbSNP
rs566339084 395 dbSNP
rs1375378702 400 dbSNP
rs974641907 403 dbSNP
rs1324983937 408 dbSNP
rs1347917754 409 dbSNP
rs1057001164 415 dbSNP
rs1028827271 418 dbSNP
rs112653490 419 dbSNP
rs549156055 425 dbSNP
rs1429357707 438 dbSNP
rs1262091208 442 dbSNP
rs1330319066 450 dbSNP
rs1206674243 454 dbSNP
rs567278877 464 dbSNP
rs1369283508 470 dbSNP
rs986732637 479 dbSNP
rs1230624900 490 dbSNP
rs1482235552 492 dbSNP
rs1259143236 496 dbSNP
rs188309120 497 dbSNP
rs371544429 500 dbSNP
rs1210484484 501 dbSNP
rs1269605131 510 dbSNP
rs1294809347 511 dbSNP
rs1226179920 512 dbSNP
rs1326671625 513 dbSNP
rs912579333 518 dbSNP
rs762405880 526 dbSNP
rs940058475 526 dbSNP
rs1314063925 527 dbSNP
rs1437157008 528 dbSNP
rs1489837501 535 dbSNP
rs1167419913 541 dbSNP
rs1462624647 549 dbSNP
rs1384208940 551 dbSNP
rs1195049550 555 dbSNP
rs555902485 563 dbSNP
rs903635954 564 dbSNP
rs936305835 565 dbSNP
rs1049447074 585 dbSNP
rs1486625032 586 dbSNP
rs889665445 587 dbSNP
rs920059074 589 dbSNP
rs1473414656 592 dbSNP
rs1194741990 594 dbSNP
rs1339655112 595 dbSNP
rs1008146829 601 dbSNP
rs931472925 602 dbSNP
rs1355179332 607 dbSNP
rs1294312774 615 dbSNP
rs751480856 622 dbSNP
rs1055306181 634 dbSNP
rs895366485 635 dbSNP
rs768640748 636 dbSNP
rs1328262610 642 dbSNP
rs896998344 647 dbSNP
rs1458142795 659 dbSNP
rs1164463016 662 dbSNP
rs949630058 664 dbSNP
rs1046075113 671 dbSNP
rs1461154157 672 dbSNP
rs1416836533 673 dbSNP
rs1165398578 683 dbSNP
rs1363247251 683 dbSNP
rs1026337775 684 dbSNP
rs1303015782 698 dbSNP
rs1437944264 704 dbSNP
rs1252088183 707 dbSNP
rs1333718439 710 dbSNP
rs144859773 710 dbSNP
rs999232914 714 dbSNP
rs1235599174 718 dbSNP
rs1327680917 719 dbSNP
rs1393449263 721 dbSNP
rs774011553 726 dbSNP
rs1279540172 734 dbSNP
rs1305371412 738 dbSNP
rs1337574310 756 dbSNP
rs549458954 757 dbSNP
rs1321698462 758 dbSNP
rs1033693534 766 dbSNP
rs1316521111 776 dbSNP
rs1395498883 780 dbSNP
rs959851609 784 dbSNP
rs540144093 788 dbSNP
rs1485913722 805 dbSNP
rs1294020339 824 dbSNP
rs1357294298 843 dbSNP
rs191899682 844 dbSNP
rs1221852607 845 dbSNP
rs1252403991 849 dbSNP
rs1296724188 860 dbSNP
rs1364965354 861 dbSNP
rs1191207468 872 dbSNP
rs1467746364 885 dbSNP
rs1484009563 889 dbSNP
rs992442354 892 dbSNP
rs1215920732 906 dbSNP
rs918051665 913 dbSNP
rs11554734 914 dbSNP
rs1284052742 915 dbSNP
rs542678246 926 dbSNP
rs1249607176 928 dbSNP
rs1032504009 940 dbSNP
rs945516412 943 dbSNP
rs978282069 960 dbSNP
rs893559366 961 dbSNP
rs1371986691 964 dbSNP
rs1305945724 966 dbSNP
rs995931942 969 dbSNP
rs1433205622 972 dbSNP
rs925024618 974 dbSNP
rs561442561 975 dbSNP
rs1387128969 983 dbSNP
rs1028794487 984 dbSNP
rs1453317259 989 dbSNP
rs936410648 991 dbSNP
rs1195072601 994 dbSNP
rs11554736 1017 dbSNP
rs1049820425 1033 dbSNP
rs573570870 1034 dbSNP
rs987330084 1035 dbSNP
rs1216964642 1041 dbSNP
rs1014824364 1047 dbSNP
rs1449232383 1050 dbSNP
rs1371686747 1052 dbSNP
rs1464013837 1054 dbSNP
rs184327324 1070 dbSNP
rs1348630905 1072 dbSNP
rs1305746132 1075 dbSNP
rs1296802374 1077 dbSNP
rs943922315 1079 dbSNP
rs1361533012 1091 dbSNP
rs961669418 1099 dbSNP
rs972798525 1101 dbSNP
rs897100755 1103 dbSNP
rs1311038707 1110 dbSNP
rs1434063543 1111 dbSNP
rs993958123 1113 dbSNP
rs1026809625 1115 dbSNP
rs919966324 1127 dbSNP
rs865841894 1128 dbSNP
rs887829362 1136 dbSNP
rs1380900527 1139 dbSNP
rs931425014 1155 dbSNP
rs761646969 1157 dbSNP
rs1275508975 1158 dbSNP
rs1255884543 1184 dbSNP
rs916770358 1185 dbSNP
rs766558446 1187 dbSNP
rs562291132 1192 dbSNP
rs1282478861 1195 dbSNP
rs189099288 1199 dbSNP
rs1307120337 1200 dbSNP
rs1202437356 1201 dbSNP
rs1274034962 1215 dbSNP
rs1046672959 1216 dbSNP
rs992598719 1222 dbSNP
rs778670521 1232 dbSNP
rs1335499667 1235 dbSNP
rs1291238503 1242 dbSNP
rs1025208425 1243 dbSNP
rs1356020930 1263 dbSNP
rs1314173657 1273 dbSNP
rs1439465758 1275 dbSNP
rs1353539879 1276 dbSNP
rs902802254 1277 dbSNP
rs181830776 1279 dbSNP
rs1183386093 1280 dbSNP
rs1053462439 1283 dbSNP
rs1411321399 1290 dbSNP
rs139802273 1291 dbSNP
rs1475818020 1301 dbSNP
rs1260295438 1309 dbSNP
rs377700019 1313 dbSNP
rs1443680550 1315 dbSNP
rs995900662 1328 dbSNP
rs533115679 1329 dbSNP
rs910990532 1334 dbSNP
rs1467323512 1340 dbSNP
rs1270971121 1341 dbSNP
rs1232526066 1342 dbSNP
rs890272801 1347 dbSNP
rs879168453 1348 dbSNP
rs375357531 1355 dbSNP
rs1168879010 1359 dbSNP
rs1221545463 1360 dbSNP
rs1015253910 1368 dbSNP
rs961990609 1376 dbSNP
rs1298262940 1386 dbSNP
rs146202000 1386 dbSNP
rs560062381 1387 dbSNP
rs1391917843 1389 dbSNP
rs34875796 1392 dbSNP
rs548941354 1394 dbSNP
rs929903589 1395 dbSNP
rs1408740194 1397 dbSNP
rs118072044 1401 dbSNP
rs888299327 1405 dbSNP
rs970881728 1411 dbSNP
rs185798726 1417 dbSNP
rs1468782383 1418 dbSNP
rs1267027675 1423 dbSNP
rs924151274 1427 dbSNP
rs1298418512 1428 dbSNP
rs935607244 1429 dbSNP
rs1055203351 1431 dbSNP
rs1212897811 1439 dbSNP
rs895246367 1450 dbSNP
rs1302281355 1456 dbSNP
rs1013587303 1458 dbSNP
rs1053840365 1459 dbSNP
rs139207148 1460 dbSNP
rs931677720 1465 dbSNP
rs1272403555 1471 dbSNP
rs142589818 1485 dbSNP
rs189034317 1491 dbSNP
rs1452713234 1492 dbSNP
rs966910373 1495 dbSNP
rs999795398 1504 dbSNP
rs1455755902 1505 dbSNP
rs150982950 1506 dbSNP
rs1008646475 1515 dbSNP
rs1036207186 1516 dbSNP
rs774208001 1526 dbSNP
rs573611367 1528 dbSNP
rs897710738 1539 dbSNP
rs765176894 1541 dbSNP
rs2286382 1542 dbSNP
rs180939065 1550 dbSNP
rs1293881190 1555 dbSNP
rs1469471235 1564 dbSNP
rs1382076795 1571 dbSNP
rs1363245168 1572 dbSNP
rs989899279 1578 dbSNP
rs952678931 1580 dbSNP
rs1374879484 1581 dbSNP
rs1174342523 1582 dbSNP
rs574128778 1589 dbSNP
rs544387816 1593 dbSNP
rs1347187002 1604 dbSNP
rs1371614210 1613 dbSNP
rs139590556 1617 dbSNP
rs918255398 1618 dbSNP
rs929872551 1635 dbSNP
rs758828785 1640 dbSNP
rs1484656870 1641 dbSNP
rs12342 1643 dbSNP
rs550919091 1644 dbSNP
rs1346673428 1649 dbSNP
rs1262158607 1650 dbSNP
rs1249309889 1655 dbSNP
rs1227112809 1658 dbSNP
rs1308408231 1662 dbSNP
rs924150758 1665 dbSNP
rs35235944 1667 dbSNP
rs2286381 1671 dbSNP
rs1322490065 1673 dbSNP
rs989734294 1674 dbSNP
rs1397910802 1683 dbSNP
rs569041107 1686 dbSNP
rs751947338 1692 dbSNP
rs377341763 1701 dbSNP
rs1462705406 1707 dbSNP
rs1423996052 1711 dbSNP
rs1044471 1719 dbSNP
rs1474184312 1722 dbSNP
rs1444949524 1725 dbSNP
rs1417155637 1729 dbSNP
rs1188023953 1733 dbSNP
rs373558976 1736 dbSNP
rs1443682798 1743 dbSNP
rs1247847132 1744 dbSNP
rs1194829712 1745 dbSNP
rs1214436192 1747 dbSNP
rs186160725 1749 dbSNP
rs1231905297 1754 dbSNP
rs147857332 1757 dbSNP
rs911608025 1760 dbSNP
rs1294479568 1767 dbSNP
rs531496109 1795 dbSNP
rs1036584245 1796 dbSNP
rs549702604 1797 dbSNP
rs141510300 1807 dbSNP
rs1480277158 1808 dbSNP
rs1392110308 1810 dbSNP
rs761798994 1810 dbSNP
rs1333104902 1815 dbSNP
rs1459724161 1823 dbSNP
rs1410411189 1824 dbSNP
rs1417043643 1831 dbSNP
rs1163735491 1832 dbSNP
rs7965288 1840 dbSNP
rs745464908 1841 dbSNP
rs999553972 1850 dbSNP
rs1032575445 1853 dbSNP
rs894398365 1856 dbSNP
rs1012218856 1861 dbSNP
rs958570509 1866 dbSNP
rs1274220992 1875 dbSNP
rs1007050111 1877 dbSNP
rs1023651892 1881 dbSNP
rs1158470650 1892 dbSNP
rs1350596883 1900 dbSNP
rs7965379 1902 dbSNP
rs965117812 1904 dbSNP
rs976490261 1905 dbSNP
rs1301576509 1906 dbSNP
rs1301139345 1909 dbSNP
rs147038940 1923 dbSNP
rs1031533059 1924 dbSNP
rs951039824 1931 dbSNP
rs779364818 1933 dbSNP
rs1406955047 1934 dbSNP
rs1382769878 1947 dbSNP
rs983776341 1953 dbSNP
rs1419817912 1954 dbSNP
rs909802538 1963 dbSNP
rs1191309007 1966 dbSNP
rs1453435273 1971 dbSNP
rs956886228 1973 dbSNP
rs937292140 1979 dbSNP
rs990095432 1989 dbSNP
rs1217393759 1995 dbSNP
rs1284239523 1995 dbSNP
rs917085406 1999 dbSNP
rs949466168 2004 dbSNP
rs370236885 2005 dbSNP
rs902621513 2013 dbSNP
rs748893641 2014 dbSNP
rs555984880 2017 dbSNP
rs985731667 2025 dbSNP
rs1053819781 2027 dbSNP
rs894023029 2028 dbSNP
rs1361830932 2030 dbSNP
rs566609610 2038 dbSNP
rs781252586 2042 dbSNP
rs2286380 2047 dbSNP
rs1433708924 2050 dbSNP
rs1425503474 2057 dbSNP
rs1182943435 2070 dbSNP
rs1474654793 2071 dbSNP
rs1235026970 2072 dbSNP
rs1194974388 2076 dbSNP
rs1468785119 2085 dbSNP
rs944402186 2087 dbSNP
rs1210346602 2088 dbSNP
rs1312970738 2090 dbSNP
rs1176774621 2101 dbSNP
rs1386094854 2120 dbSNP
rs971828894 2131 dbSNP
rs901352000 2132 dbSNP
rs1269391201 2136 dbSNP
rs919037170 2144 dbSNP
rs998339430 2161 dbSNP
rs930452601 2170 dbSNP
rs34877278 2174 dbSNP
rs111477952 2176 dbSNP
rs948633581 2180 dbSNP
rs1430379500 2187 dbSNP
rs1330638796 2188 dbSNP
rs1335738622 2189 dbSNP
rs1333826987 2191 dbSNP
rs1407883042 2191 dbSNP
rs1441226323 2193 dbSNP
rs1284355797 2195 dbSNP
rs748117322 2197 dbSNP
rs143312255 2198 dbSNP
rs906518440 2205 dbSNP
rs1479087932 2213 dbSNP
rs1483594188 2219 dbSNP
rs545067188 2219 dbSNP
rs1290450697 2221 dbSNP
rs1202625035 2229 dbSNP
rs148347534 2231 dbSNP
rs1359340471 2232 dbSNP
rs991826519 2233 dbSNP
rs1319888569 2236 dbSNP
rs917200590 2237 dbSNP
rs1031080575 2238 dbSNP
rs892548232 2241 dbSNP
rs1011041275 2249 dbSNP
rs1304097446 2252 dbSNP
rs1439492435 2253 dbSNP
rs1353631821 2256 dbSNP
rs949844824 2257 dbSNP
rs977290186 2258 dbSNP
rs1392776229 2268 dbSNP
rs1164768888 2281 dbSNP
rs773006359 2282 dbSNP
rs909685299 2287 dbSNP
rs953607203 2294 dbSNP
rs568726719 2306 dbSNP
rs1204300718 2319 dbSNP
rs759691170 2322 dbSNP
rs935409703 2323 dbSNP
rs765564040 2324 dbSNP
rs1199007658 2326 dbSNP
rs1458897615 2329 dbSNP
rs757815464 2332 dbSNP
rs965735274 2333 dbSNP
rs1384761354 2334 dbSNP
rs1322265263 2339 dbSNP
rs1475695397 2346 dbSNP
rs572359608 2361 dbSNP
rs1169523395 2362 dbSNP
rs11554735 2367 dbSNP
rs1314250982 2370 dbSNP
rs1375651948 2375 dbSNP
rs542569124 2377 dbSNP
rs1394256304 2378 dbSNP
rs1409114594 2384 dbSNP
rs893812592 2388 dbSNP
rs1407819723 2396 dbSNP
rs1325655934 2399 dbSNP
rs942942429 2417 dbSNP
rs972181118 2428 dbSNP
rs1040341722 2438 dbSNP
rs1156984906 2447 dbSNP
rs1400236398 2457 dbSNP
rs1381038184 2460 dbSNP
rs1180692899 2465 dbSNP
rs1452824565 2467 dbSNP
rs901453271 2470 dbSNP
rs1190478747 2476 dbSNP
rs1267202657 2486 dbSNP
rs1488760735 2486 dbSNP
rs998300195 2500 dbSNP
rs1352269282 2506 dbSNP
rs1286120814 2512 dbSNP
rs918978309 2516 dbSNP
rs1241779383 2525 dbSNP
rs1345378186 2527 dbSNP
rs1301002196 2529 dbSNP
rs930401258 2533 dbSNP
rs1387755323 2534 dbSNP
rs763139134 2536 dbSNP
rs1287590935 2543 dbSNP
rs141538159 2545 dbSNP
rs764473778 2552 dbSNP
rs35187506 2557 dbSNP
rs1160538959 2558 dbSNP
rs752070099 2559 dbSNP
rs1005265025 2561 dbSNP
rs1016579614 2563 dbSNP
rs958599851 2564 dbSNP
rs181395173 2566 dbSNP
rs1269224703 2571 dbSNP
rs991201712 2574 dbSNP
rs1487922472 2576 dbSNP
rs1024636921 2580 dbSNP
rs928574818 2586 dbSNP
rs1218235439 2590 dbSNP
rs745699618 2591 dbSNP
rs1255090133 2597 dbSNP
rs767934769 2599 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' gacAAGAGA-AGG-AA------ACCGGAAc 5'
             ||||:|  || ||      ||||||| 
Target 5' ucaUUCUUUCACCAUUAAAUAGUGGCCUUu 3'
 		3 - 32
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000357103.4 | 3UTR | CUUCAUUCUUUCACCAUUAAAUAGUGGCCUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
94 hsa-miR-4753-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT064916 ZBTB18 zinc finger and BTB domain containing 18 2 2
MIRT161166 SLC25A36 solute carrier family 25 member 36 2 2
MIRT285542 CDT1 chromatin licensing and DNA replication factor 1 2 2
MIRT308266 LRIG1 leucine rich repeats and immunoglobulin like domains 1 2 2
MIRT311425 LMNB1 lamin B1 2 2
MIRT373989 PEBP1 phosphatidylethanolamine binding protein 1 2 4
MIRT383141 CRY2 cryptochrome circadian clock 2 2 2
MIRT405243 ADIPOR2 adiponectin receptor 2 2 2
MIRT441620 ROCK1 Rho associated coiled-coil containing protein kinase 1 2 6
MIRT441789 SRPK1 SRSF protein kinase 1 2 2
MIRT441804 NOC3L NOC3 like DNA replication regulator 2 2
MIRT441832 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT442005 NDUFV3 NADH:ubiquinone oxidoreductase subunit V3 2 2
MIRT442411 LIMD1 LIM domains containing 1 2 2
MIRT442708 UBE4B ubiquitination factor E4B 2 2
MIRT442714 TNRC6B trinucleotide repeat containing 6B 2 2
MIRT442738 SERINC5 serine incorporator 5 2 2
MIRT442793 CEP170 centrosomal protein 170 2 2
MIRT442984 ZNF736 zinc finger protein 736 2 2
MIRT443055 THRB thyroid hormone receptor beta 2 2
MIRT443288 ZC3H12A zinc finger CCCH-type containing 12A 2 2
MIRT443325 SLC35G1 solute carrier family 35 member G1 2 2
MIRT443331 OCRL OCRL, inositol polyphosphate-5-phosphatase 2 2
MIRT443593 ZNF439 zinc finger protein 439 2 4
MIRT443696 KCNN3 potassium calcium-activated channel subfamily N member 3 2 2
MIRT443748 ELL2 elongation factor for RNA polymerase II 2 2 2
MIRT443866 HDLBP high density lipoprotein binding protein 2 2
MIRT461185 LTBP2 latent transforming growth factor beta binding protein 2 2 2
MIRT464074 WAC WW domain containing adaptor with coiled-coil 2 2
MIRT468738 SDC4 syndecan 4 2 2
MIRT470540 COASY Coenzyme A synthase 2 2
MIRT476458 GBA2 glucosylceramidase beta 2 2 2
MIRT479470 CDK6 cyclin dependent kinase 6 2 2
MIRT486351 TACC2 transforming acidic coiled-coil containing protein 2 2 8
MIRT495126 CXorf67 chromosome X open reading frame 67 2 2
MIRT495166 CNGA2 cyclic nucleotide gated channel alpha 2 2 4
MIRT495432 ATG7 autophagy related 7 2 2
MIRT495922 FBXO41 F-box protein 41 2 2
MIRT496572 DGCR6L DiGeorge syndrome critical region gene 6 like 2 2
MIRT498277 POFUT1 protein O-fucosyltransferase 1 2 2
MIRT498431 DDX39A DExD-box helicase 39A 2 2
MIRT530149 HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 2 2
MIRT530313 TNFRSF10D TNF receptor superfamily member 10d 2 2
MIRT530880 TRUB1 TruB pseudouridine synthase family member 1 2 4
MIRT531177 ZNF626 zinc finger protein 626 2 2
MIRT533395 TYRP1 tyrosinase related protein 1 2 2
MIRT533709 TMEM64 transmembrane protein 64 2 2
MIRT533954 TAF1D TATA-box binding protein associated factor, RNA polymerase I subunit D 2 2
MIRT535616 NSD1 nuclear receptor binding SET domain protein 1 2 2
MIRT539472 ADARB2 adenosine deaminase, RNA specific B2 (inactive) 2 2
MIRT542878 NR6A1 nuclear receptor subfamily 6 group A member 1 2 2
MIRT559077 C19orf47 chromosome 19 open reading frame 47 2 2
MIRT559465 ARPP19 cAMP regulated phosphoprotein 19 2 2
MIRT561233 ZNF772 zinc finger protein 772 2 2
MIRT563477 POLE3 DNA polymerase epsilon 3, accessory subunit 2 2
MIRT563995 SLFN11 schlafen family member 11 2 2
MIRT564222 SDE2 SDE2 telomere maintenance homolog 2 2
MIRT566017 RHOA ras homolog family member A 2 2
MIRT566028 RFX1 regulatory factor X1 2 2
MIRT566591 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 2
MIRT567874 CTDSP1 CTD small phosphatase 1 2 2
MIRT568552 AKT2 AKT serine/threonine kinase 2 2 2
MIRT569357 EFHC1 EF-hand domain containing 1 2 2
MIRT569973 DNAAF2 dynein axonemal assembly factor 2 2 2
MIRT614423 ZNF440 zinc finger protein 440 2 2
MIRT628831 SLC25A34 solute carrier family 25 member 34 2 2
MIRT630142 ZFYVE9 zinc finger FYVE-type containing 9 2 2
MIRT634479 PAFAH1B2 platelet activating factor acetylhydrolase 1b catalytic subunit 2 2 2
MIRT634498 OR7D2 olfactory receptor family 7 subfamily D member 2 2 2
MIRT637394 R3HDM2 R3H domain containing 2 2 2
MIRT641840 TCF7L2 transcription factor 7 like 2 2 2
MIRT644397 CDKL1 cyclin dependent kinase like 1 2 2
MIRT644888 C2orf50 chromosome 2 open reading frame 50 2 2
MIRT647124 ZNF446 zinc finger protein 446 2 2
MIRT647420 SSTR3 somatostatin receptor 3 2 2
MIRT650297 PYCARD PYD and CARD domain containing 2 2
MIRT655488 PAK3 p21 (RAC1) activated kinase 3 2 2
MIRT658185 FBXO9 F-box protein 9 2 2
MIRT660931 ADAM19 ADAM metallopeptidase domain 19 2 2
MIRT665317 ZBTB3 zinc finger and BTB domain containing 3 2 2
MIRT670350 C1orf106 chromosome 1 open reading frame 106 2 4
MIRT670823 NICN1 nicolin 1 2 2
MIRT671825 TRPM6 transient receptor potential cation channel subfamily M member 6 2 2
MIRT672732 NETO2 neuropilin and tolloid like 2 2 2
MIRT674841 GLRX2 glutaredoxin 2 2 2
MIRT675930 CYP51A1 cytochrome P450 family 51 subfamily A member 1 2 2
MIRT686786 AZF1 azoospermia factor 1 2 2
MIRT697723 USP8 ubiquitin specific peptidase 8 2 2
MIRT702357 KLHL26 kelch like family member 26 2 2
MIRT704361 DBR1 debranching RNA lariats 1 2 2
MIRT709242 RANGAP1 Ran GTPase activating protein 1 2 2
MIRT714433 SNED1 sushi, nidogen and EGF like domains 1 2 2
MIRT717000 ARL6IP4 ADP ribosylation factor like GTPase 6 interacting protein 4 2 2
MIRT720875 ADCY5 adenylate cyclase 5 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4753 Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-miR-4753-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-4753-5p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-4753-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (H1975)
hsa-miR-4753-5p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-4753-5p Platinum 23939 resistant tissue
hsa-miR-4753-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4753-5p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (100 ng/ml)
hsa-miR-4753-5p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR4)

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