miRTarBase - #MIRT405482


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pre-miRNA Information
pre-miRNA hsa-mir-4695   
Genomic Coordinates chr1: 18883202 - 18883275
Description Homo sapiens miR-4695 stem-loop
Comment None
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-4695-3p
Sequence 51| UGAUCUCACCGCUGCCUCCUUC |72
Evidence Experimental
Experiments Illumina
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1264904031 5 dbSNP
rs373926482 10 dbSNP
rs778369521 11 dbSNP
rs1445913612 13 dbSNP
rs1259104824 14 dbSNP
rs200517905 16 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol ARID1A   
Synonyms B120, BAF250, BAF250a, BM029, C1orf4, CSS2, ELD, MRD14, OSA1, P270, SMARCF1, hELD, hOSA1
Description AT-rich interaction domain 1A
Transcript NM_006015   
Other Transcripts NM_139135   
Expression
Putative miRNA Targets on ARID1A
3'UTR of ARID1A
(miRNA target sites are highlighted)		 
>ARID1A|NM_006015|3'UTR
   1 CAGCCGTGGGACACCTCCCCCCCCCGTGTGTGTGTGCGTGTGTGGAGAACTTAGAAACTGACTGTTGCCCTTTATTTATG
  81 CAAAACCACCTCAGAATCCAGTTTACCCTGTGCTGTCCAGCTTCTCCCTTGGGAAAAAGTCTCTCCTGTTTCTCTCTCCT
 161 CCTTCCACCTCCCCTCCCTCCATCACCTCACGCCTTTCTGTTCCTTGTCCTCACCTTACTCCCCTCAGGACCCTACCCCA
 241 CCCTCTTTGAAAAGACAAAGCTCTGCCTACATAGAAGACTTTTTTTATTTTAACCAAAGTTACTGTTGTTTACAGTGAGT
 321 TTGGGGAAAAAAAATAAAATAAAAATGGCTTTCCCAGTCCTTGCATCAACGGGATGCCACATTTCATAACTGTTTTTAAT
 401 GGTAAAAAAAAAAAAAAAAAATACAAAAAAAAATTCTGAAGGACAAAAAAGGTGACTGCTGAACTGTGTGTGGTTTATTG
 481 TTGTACATTCACAATCTTGCAGGAGCCAAGAAGTTCGCAGTTGTGAACAGACCCTGTTCACTGGAGAGGCCTGTGCAGTA
 561 GAGTGTAGACCCTTTCATGTACTGTACTGTACACCTGATACTGTAAACATACTGTAATAATAATGTCTCACATGGAAACA
 641 GAAAACGCTGGGTCAGCAGCAAGCTGTAGTTTTTAAAAATGTTTTTAGTTAAACGTTGAGGAGAAAAAAAAAAAAGGCTT
 721 TTCCCCCAAAGTATCATGTGTGAACCTACAACACCCTGACCTCTTTCTCTCCTCCTTGATTGTATGAATAACCCTGAGAT
 801 CACCTCTTAGAACTGGTTTTAACCTTTAGCTGCAGCGGCTACGCTGCCACGTGTGTATATATATGACGTTGTACATTGCA
 881 CATACCCTTGGATCCCCACAGTTTGGTCCTCCTCCCAGCTACCCCTTTATAGTATGACGAGTTAACAAGTTGGTGACCTG
 961 CACAAAGCGAGACACAGCTATTTAATCTCTTGCCAGATATCGCCCCTCTTGGTGCGATGCTGTACAGGTCTCTGTAAAAA
1041 GTCCTTGCTGTCTCAGCAGCCAATCAACTTATAGTTTATTTTTTTCTGGGTTTTTGTTTTGTTTTGTTTTCTTTCTAATC
1121 GAGGTGTGAAAAAGTTCTAGGTTCAGTTGAAGTTCTGATGAAGAAACACAATTGAGATTTTTTCAGTGATAAAATCTGCA
1201 TATTTGTATTTCAACAATGTAGCTAAAACTTGATGTAAATTCCTCCTTTTTTTCCTTTTTTGGCTTAATGAATATCATTT
1281 ATTCAGTATGAAATCTTTATACTATATGTTCCACGTGTTAAGAATAAATGTACATTAAATCTTGGTAAGACTTT
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuUCCUCCGUCGCCACUCUAGu 5'
            | ||  :| |  ||||||| 
Target 5' gtATGA-ATAACCCTGAGATCa 3'
 782 - 802 143.00 -9.30
2 
miRNA  3' cuUCCUCCGUCGCCACUCUAGu 5'
            | ||  ||    ||||||: 
Target 5' tgAAGAAACACAATTGAGATTt 3'
 1159 - 1180 128.00 -7.20
3 
miRNA  3' cuuccuccGUCGCCACUCUAGu 5'
                  |||:  ||| ||| 
Target 5' catttattCAGT-ATGAAATCt 3'
 1276 - 1296 113.00 -5.40
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
1192736 6 ClinVar
1197106 11 ClinVar
COSN31594347 6 COSMIC
COSN30468855 18 COSMIC
COSN30552090 25 COSMIC
COSN30548382 26 COSMIC
COSN20074011 38 COSMIC
COSN30097813 93 COSMIC
COSN25846364 140 COSMIC
COSN31541229 196 COSMIC
COSN31596748 270 COSMIC
COSN30170887 271 COSMIC
COSN31594795 335 COSMIC
COSN19365852 422 COSMIC
COSN30174930 526 COSMIC
COSN22872902 608 COSMIC
COSN19304313 621 COSMIC
COSN28578908 675 COSMIC
COSN27402416 716 COSMIC
COSN29066575 716 COSMIC
COSN31769385 737 COSMIC
COSN31532324 811 COSMIC
COSN31513608 847 COSMIC
COSN31960201 852 COSMIC
COSN31535903 856 COSMIC
COSN31484548 970 COSMIC
COSN31556897 990 COSMIC
COSN31565426 1002 COSMIC
COSN26509054 1009 COSMIC
COSN26677618 1013 COSMIC
COSN31523204 1029 COSMIC
COSN31593976 1063 COSMIC
COSN31523201 1074 COSMIC
COSN31769386 1183 COSMIC
COSN31568545 1185 COSMIC
COSN31769390 1187 COSMIC
COSN31769393 1191 COSMIC
COSN32061019 1198 COSMIC
COSN31606438 1272 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs748607027 2 dbSNP
rs768407935 3 dbSNP
rs201289176 6 dbSNP
rs761262959 7 dbSNP
rs572794512 8 dbSNP
rs372029026 11 dbSNP
rs763359043 14 dbSNP
rs1371743129 16 dbSNP
rs1491421314 17 dbSNP
rs369896037 17 dbSNP
rs551176418 17 dbSNP
rs745390232 17 dbSNP
rs377238538 18 dbSNP
rs755516865 19 dbSNP
rs1263075449 21 dbSNP
rs774971536 21 dbSNP
rs377624643 22 dbSNP
rs760439531 22 dbSNP
rs763858866 23 dbSNP
rs778187938 23 dbSNP
rs200568725 24 dbSNP
rs776428236 24 dbSNP
rs1441882203 25 dbSNP
rs1491399260 25 dbSNP
rs201547182 26 dbSNP
rs3841356 26 dbSNP
rs750470371 26 dbSNP
rs199555039 27 dbSNP
rs1314517111 29 dbSNP
rs761352508 35 dbSNP
rs769273623 36 dbSNP
rs375168652 38 dbSNP
rs114615474 39 dbSNP
rs751971163 43 dbSNP
rs759773973 46 dbSNP
rs915071595 48 dbSNP
rs1387972191 55 dbSNP
rs994830363 59 dbSNP
rs1462055512 64 dbSNP
rs1328126265 69 dbSNP
rs1454399182 83 dbSNP
rs193200602 87 dbSNP
rs1028353479 99 dbSNP
rs1239740672 106 dbSNP
rs953605214 108 dbSNP
rs570966006 111 dbSNP
rs1288293349 113 dbSNP
rs1007771911 119 dbSNP
rs1264000698 129 dbSNP
rs1462893445 130 dbSNP
rs1019086140 134 dbSNP
rs965796800 140 dbSNP
rs1250317878 150 dbSNP
rs201874010 151 dbSNP
rs969224680 153 dbSNP
rs981247939 167 dbSNP
rs762599015 169 dbSNP
rs185013013 170 dbSNP
rs1479178017 179 dbSNP
rs1181304090 191 dbSNP
rs1205766877 192 dbSNP
rs751706703 193 dbSNP
rs1406403111 201 dbSNP
rs1470776155 204 dbSNP
rs989824139 207 dbSNP
rs377690379 213 dbSNP
rs928091627 217 dbSNP
rs939320870 220 dbSNP
rs1395579085 225 dbSNP
rs1036374197 233 dbSNP
rs868709218 234 dbSNP
rs1391892783 238 dbSNP
rs190650562 239 dbSNP
rs948598431 240 dbSNP
rs1408417706 241 dbSNP
rs1307887735 245 dbSNP
rs930879662 252 dbSNP
rs1235734781 255 dbSNP
rs1309946194 256 dbSNP
rs1320638749 263 dbSNP
rs928443330 266 dbSNP
rs757365605 268 dbSNP
rs566849047 269 dbSNP
rs1227680069 272 dbSNP
rs889275126 273 dbSNP
rs1481929277 275 dbSNP
rs766238144 280 dbSNP
rs939470085 280 dbSNP
rs1486603790 282 dbSNP
rs1044113 288 dbSNP
rs1223004626 300 dbSNP
rs1180113728 313 dbSNP
rs1411692272 320 dbSNP
rs1171345252 327 dbSNP
rs1284114092 327 dbSNP
rs369865650 327 dbSNP
rs1325901660 330 dbSNP
rs1392259519 331 dbSNP
rs550131155 331 dbSNP
rs1168337088 335 dbSNP
rs1376510290 336 dbSNP
rs897898640 342 dbSNP
rs1007749223 346 dbSNP
rs1301660848 353 dbSNP
rs1049058386 358 dbSNP
rs1382332074 360 dbSNP
rs144625506 371 dbSNP
rs1339653193 372 dbSNP
rs1481169558 375 dbSNP
rs1198014666 383 dbSNP
rs1187195724 387 dbSNP
rs1250042738 390 dbSNP
rs1188206844 391 dbSNP
rs1447878196 391 dbSNP
rs1396050280 393 dbSNP
rs1007784903 403 dbSNP
rs140784604 403 dbSNP
rs1174528243 404 dbSNP
rs1217268548 404 dbSNP
rs1372859595 404 dbSNP
rs531891434 404 dbSNP
rs533673675 404 dbSNP
rs71007893 404 dbSNP
rs71582803 404 dbSNP
rs879190726 404 dbSNP
rs1019140683 405 dbSNP
rs966221010 408 dbSNP
rs1429436211 413 dbSNP
rs1481204994 415 dbSNP
rs999017389 420 dbSNP
rs1188114808 421 dbSNP
rs140247425 422 dbSNP
rs879067977 423 dbSNP
rs1385781858 425 dbSNP
rs1424979331 425 dbSNP
rs201576837 425 dbSNP
rs957140373 425 dbSNP
rs990224567 425 dbSNP
rs1022551333 427 dbSNP
rs969962710 429 dbSNP
rs1036660091 437 dbSNP
rs981301637 438 dbSNP
rs1274019817 443 dbSNP
rs552617811 447 dbSNP
rs192390664 449 dbSNP
rs139737956 455 dbSNP
rs972587229 481 dbSNP
rs1303826808 482 dbSNP
rs919377839 485 dbSNP
rs1453530028 487 dbSNP
rs1219728139 489 dbSNP
rs1246460797 491 dbSNP
rs866265719 503 dbSNP
rs1184917444 509 dbSNP
rs1049101049 517 dbSNP
rs750577664 518 dbSNP
rs1164990786 520 dbSNP
rs1415411446 525 dbSNP
rs1295149514 534 dbSNP
rs1322530817 535 dbSNP
rs1030625284 540 dbSNP
rs1354846836 542 dbSNP
rs1411465866 557 dbSNP
rs1306038878 564 dbSNP
rs183673478 566 dbSNP
rs1230115951 572 dbSNP
rs1284851133 577 dbSNP
rs1264096542 578 dbSNP
rs943331229 578 dbSNP
rs1226801481 579 dbSNP
rs1289460947 580 dbSNP
rs1010767671 587 dbSNP
rs1207755836 588 dbSNP
rs1040674568 589 dbSNP
rs145352087 611 dbSNP
rs1189316316 615 dbSNP
rs1268970655 615 dbSNP
rs1471534613 619 dbSNP
rs1162241813 620 dbSNP
rs999468120 628 dbSNP
rs1431346731 629 dbSNP
rs1031799251 640 dbSNP
rs1260631745 647 dbSNP
rs1415289971 648 dbSNP
rs969606409 671 dbSNP
rs1336146483 675 dbSNP
rs1428849870 680 dbSNP
rs1342294407 685 dbSNP
rs1172224910 690 dbSNP
rs1445917538 694 dbSNP
rs892884880 695 dbSNP
rs573932625 696 dbSNP
rs1230974226 698 dbSNP
rs1272887783 699 dbSNP
rs1383216996 701 dbSNP
rs1423928995 702 dbSNP
rs1164141784 703 dbSNP
rs1011294855 704 dbSNP
rs1022606208 704 dbSNP
rs1212161198 704 dbSNP
rs760723895 704 dbSNP
rs1367469673 705 dbSNP
rs1428749539 720 dbSNP
rs969719142 736 dbSNP
rs981060933 737 dbSNP
rs1174211102 738 dbSNP
rs980644703 741 dbSNP
rs755982730 749 dbSNP
rs1333587077 751 dbSNP
rs779697055 762 dbSNP
rs1437514380 764 dbSNP
rs1295704549 766 dbSNP
rs972982682 766 dbSNP
rs960826442 768 dbSNP
rs546236808 770 dbSNP
rs1382588716 775 dbSNP
rs1343482452 778 dbSNP
rs749310830 781 dbSNP
rs1200457346 783 dbSNP
rs919252408 785 dbSNP
rs930659273 787 dbSNP
rs1465901163 794 dbSNP
rs1206385837 798 dbSNP
rs1454506677 804 dbSNP
rs930738590 804 dbSNP
rs1200715643 806 dbSNP
rs984895434 825 dbSNP
rs1477638772 833 dbSNP
rs985022973 835 dbSNP
rs910824315 838 dbSNP
rs943503949 842 dbSNP
rs1358365430 843 dbSNP
rs1388199644 844 dbSNP
rs1040553727 852 dbSNP
rs1303861925 856 dbSNP
rs902095027 860 dbSNP
rs900878195 864 dbSNP
rs1187969128 868 dbSNP
rs536545312 868 dbSNP
rs1052168297 869 dbSNP
rs1289548913 876 dbSNP
rs60798877 893 dbSNP
rs1226045973 895 dbSNP
rs1184076490 899 dbSNP
rs1010549686 901 dbSNP
rs1387049545 902 dbSNP
rs1488599804 905 dbSNP
rs1022141064 907 dbSNP
rs905118899 911 dbSNP
rs1264975363 912 dbSNP
rs893281882 914 dbSNP
rs778763188 915 dbSNP
rs1158452685 917 dbSNP
rs566545995 920 dbSNP
rs1414093032 922 dbSNP
rs1455533630 923 dbSNP
rs1473582132 928 dbSNP
rs1157021071 937 dbSNP
rs1411417459 939 dbSNP
rs1022699450 940 dbSNP
rs1388965067 944 dbSNP
rs1002408607 945 dbSNP
rs1334971301 947 dbSNP
rs1002535806 948 dbSNP
rs747678001 950 dbSNP
rs960857696 953 dbSNP
rs1352852079 960 dbSNP
rs572778412 969 dbSNP
rs1026425035 970 dbSNP
rs952002276 974 dbSNP
rs1246467690 975 dbSNP
rs1263340752 976 dbSNP
rs1355294489 979 dbSNP
rs1205622967 981 dbSNP
rs746879215 982 dbSNP
rs1317726068 996 dbSNP
rs1375287195 998 dbSNP
rs12685 999 dbSNP
rs1181420844 1000 dbSNP
rs1249887927 1002 dbSNP
rs1424496245 1003 dbSNP
rs910760044 1004 dbSNP
rs994071818 1005 dbSNP
rs1027296882 1009 dbSNP
rs943634804 1014 dbSNP
rs976778050 1016 dbSNP
rs1408513780 1023 dbSNP
rs188298594 1026 dbSNP
rs1460677655 1042 dbSNP
rs985282134 1046 dbSNP
rs1244800396 1051 dbSNP
rs923453125 1053 dbSNP
rs1310061934 1061 dbSNP
rs1339498312 1064 dbSNP
rs1468526124 1067 dbSNP
rs772969127 1073 dbSNP
rs1276480547 1078 dbSNP
rs1339867681 1078 dbSNP
rs964750452 1081 dbSNP
rs36117735 1086 dbSNP
rs1256548522 1087 dbSNP
rs747724215 1092 dbSNP
rs976087309 1092 dbSNP
rs1408722599 1105 dbSNP
rs1420966563 1110 dbSNP
rs1174480077 1111 dbSNP
rs1428252222 1112 dbSNP
rs528990173 1113 dbSNP
rs934925108 1115 dbSNP
rs1470448228 1121 dbSNP
rs760232227 1122 dbSNP
rs1299399036 1127 dbSNP
rs548634719 1131 dbSNP
rs544354417 1138 dbSNP
rs1301827326 1143 dbSNP
rs1313870762 1144 dbSNP
rs914796227 1146 dbSNP
rs1254308225 1158 dbSNP
rs762673189 1160 dbSNP
rs558794605 1166 dbSNP
rs1044541667 1169 dbSNP
rs555311641 1170 dbSNP
rs1280862191 1173 dbSNP
rs1322377873 1178 dbSNP
rs1426400378 1178 dbSNP
rs1435396043 1184 dbSNP
rs1223811004 1192 dbSNP
rs1264768228 1196 dbSNP
rs147234817 1201 dbSNP
rs1322061358 1216 dbSNP
rs904897761 1218 dbSNP
rs994223697 1218 dbSNP
rs1002119988 1219 dbSNP
rs1035378243 1223 dbSNP
rs1293862975 1224 dbSNP
rs567162533 1230 dbSNP
rs1481632983 1236 dbSNP
rs1197324707 1241 dbSNP
rs1322828742 1243 dbSNP
rs1229101269 1246 dbSNP
rs756317726 1246 dbSNP
rs866177135 1246 dbSNP
rs1463707738 1247 dbSNP
rs1428741691 1255 dbSNP
rs1480877517 1256 dbSNP
rs952603391 1259 dbSNP
rs1489685103 1260 dbSNP
rs1178860619 1263 dbSNP
rs1417742913 1264 dbSNP
rs1409773858 1265 dbSNP
rs1429209967 1266 dbSNP
rs537890755 1267 dbSNP
rs180769241 1269 dbSNP
rs1356760783 1273 dbSNP
rs1399732242 1275 dbSNP
rs77103907 1279 dbSNP
rs1165063956 1285 dbSNP
rs1351360742 1289 dbSNP
rs1434029488 1297 dbSNP
rs1018085560 1298 dbSNP
rs964802993 1298 dbSNP
rs1411656473 1305 dbSNP
rs547256040 1307 dbSNP
rs1300734152 1308 dbSNP
rs1290258585 1312 dbSNP
rs1327225341 1314 dbSNP
rs1223384334 1315 dbSNP
rs896302585 1316 dbSNP
rs1323815558 1329 dbSNP
rs976141554 1345 dbSNP
rs923333401 1349 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions TZM-bl
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM1462574. RNA binding protein: AGO2. Condition:TZM-bl ami BaL ...

- Whisnant AW; Bogerd HP; Flores O; Ho P; et al., 2013, mBio.

Article - Whisnant AW; Bogerd HP; Flores O; Ho P; et al.
- mBio, 2013
UNLABELLED: The question of how HIV-1 interfaces with cellular microRNA (miRNA) biogenesis and effector mechanisms has been highly controversial. Here, we first used deep sequencing of small RNAs present in two different infected cell lines (TZM-bl and C8166) and two types of primary human cells (CD4(+) peripheral blood mononuclear cells [PBMCs] and macrophages) to unequivocally demonstrate that HIV-1 does not encode any viral miRNAs. Perhaps surprisingly, we also observed that infection of T cells by HIV-1 has only a modest effect on the expression of cellular miRNAs at early times after infection. Comprehensive analysis of miRNA binding to the HIV-1 genome using the photoactivatable ribonucleoside-induced cross-linking and immunoprecipitation (PAR-CLIP) technique revealed several binding sites for cellular miRNAs, a subset of which were shown to be capable of mediating miRNA-mediated repression of gene expression. However, the main finding from this analysis is that HIV-1 transcripts are largely refractory to miRNA binding, most probably due to extensive viral RNA secondary structure. Together, these data demonstrate that HIV-1 neither encodes viral miRNAs nor strongly influences cellular miRNA expression, at least early after infection, and imply that HIV-1 transcripts have evolved to avoid inhibition by preexisting cellular miRNAs by adopting extensive RNA secondary structures that occlude most potential miRNA binding sites. IMPORTANCE: MicroRNAs (miRNAs) are a ubiquitous class of small regulatory RNAs that serve as posttranscriptional regulators of gene expression. Previous work has suggested that HIV-1 might subvert the function of the cellular miRNA machinery by expressing viral miRNAs or by dramatically altering the level of cellular miRNA expression. Using very sensitive approaches, we now demonstrate that neither of these ideas is in fact correct. Moreover, HIV-1 transcripts appear to largely avoid regulation by cellular miRNAs by adopting an extensive RNA secondary structure that occludes the ability of cellular miRNAs to interact with viral mRNAs. Together, these data suggest that HIV-1, rather than seeking to control miRNA function in infected cells, has instead evolved a mechanism to become largely invisible to cellular miRNA effector mechanisms.
LinkOut: [PMID: 23592263]
CLIP-seq Support 1 for dataset GSM1462574
Method / RBP PAR-CLIP / AGO2
Cell line / Condition TZM-bl / TZM-bl ami BaL
Location of target site ENST00000324856.7 | 3UTR | AACCUACAACACCCUGACCUCUUUCUCUCCUCCUUGAUUGUAUGAAUAACCCUG
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23592263 / GSE59944
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
133 hsa-miR-4695-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT271431 ETNK1 ethanolamine kinase 1 2 2
MIRT287899 ZNF652 zinc finger protein 652 2 2
MIRT405482 ARID1A AT-rich interaction domain 1A 2 2
MIRT441675 CXXC4 CXXC finger protein 4 2 2
MIRT442163 ARL10 ADP ribosylation factor like GTPase 10 2 2
MIRT442924 TFDP2 transcription factor Dp-2 2 2
MIRT443908 ZNF256 zinc finger protein 256 2 2
MIRT444792 TMEM251 transmembrane protein 251 2 2
MIRT447161 MFSD8 major facilitator superfamily domain containing 8 2 2
MIRT452992 CABP4 calcium binding protein 4 2 4
MIRT454347 CDKL1 cyclin dependent kinase like 1 2 2
MIRT461937 TNFSF14 TNF superfamily member 14 2 2
MIRT462299 PPM1H protein phosphatase, Mg2+/Mn2+ dependent 1H 2 2
MIRT463127 ZNF451 zinc finger protein 451 2 2
MIRT469460 REL REL proto-oncogene, NF-kB subunit 2 6
MIRT470528 PPIF peptidylprolyl isomerase F 2 2
MIRT473758 MAP3K9 mitogen-activated protein kinase kinase kinase 9 2 2
MIRT482910 ZNF845 zinc finger protein 845 2 2
MIRT497070 GTF2H5 general transcription factor IIH subunit 5 2 4
MIRT497169 EPGN epithelial mitogen 2 2
MIRT497196 DRP2 dystrophin related protein 2 2 2
MIRT514518 SHISA9 shisa family member 9 2 2
MIRT516415 COPA coatomer protein complex subunit alpha 2 2
MIRT525259 TLK2 tousled like kinase 2 2 2
MIRT525804 SOD2 superoxide dismutase 2 2 2
MIRT533723 TMEM246 transmembrane protein 246 2 2
MIRT540226 SAMD5 sterile alpha motif domain containing 5 2 2
MIRT566417 PIM3 Pim-3 proto-oncogene, serine/threonine kinase 2 2
MIRT572422 PTGES3L prostaglandin E synthase 3 like 2 2
MIRT575206 Entpd4 ectonucleoside triphosphate diphosphohydrolase 4 2 2
MIRT575327 Fbxo6 F-box protein 6 2 2
MIRT575383 Ang angiogenin, ribonuclease, RNase A family, 5 2 3
MIRT607069 POM121L7 POM121 transmembrane nucleoporin like 7 pseudogene 2 2
MIRT607660 BTN3A2 butyrophilin subfamily 3 member A2 2 2
MIRT607845 PHLDA3 pleckstrin homology like domain family A member 3 2 4
MIRT607935 ANG angiogenin 2 3
MIRT608144 SYAP1 synapse associated protein 1 2 4
MIRT612151 SIX1 SIX homeobox 1 2 4
MIRT615709 MYO16 myosin XVI 2 2
MIRT617556 MTO1 mitochondrial tRNA translation optimization 1 2 2
MIRT618062 ZNF799 zinc finger protein 799 2 2
MIRT618515 SELPLG selectin P ligand 2 2
MIRT618906 CDK9 cyclin dependent kinase 9 2 2
MIRT621160 RTTN rotatin 2 2
MIRT624169 DGKE diacylglycerol kinase epsilon 2 2
MIRT624953 SERF2 small EDRK-rich factor 2 2 2
MIRT625465 ZNF135 zinc finger protein 135 2 2
MIRT627786 RAB11FIP1 RAB11 family interacting protein 1 2 2
MIRT629274 CD84 CD84 molecule 2 2
MIRT629311 ZNF566 zinc finger protein 566 2 2
MIRT629569 FAM180B family with sequence similarity 180 member B 2 4
MIRT629667 USP1 ubiquitin specific peptidase 1 2 2
MIRT630486 DHTKD1 dehydrogenase E1 and transketolase domain containing 1 2 2
MIRT631017 DNAJC22 DnaJ heat shock protein family (Hsp40) member C22 2 2
MIRT631192 TSPAN14 tetraspanin 14 2 2
MIRT631970 YIPF5 Yip1 domain family member 5 2 2
MIRT632246 VPS41 VPS41, HOPS complex subunit 2 2
MIRT632890 GINM1 glycoprotein integral membrane 1 2 2
MIRT634499 NYAP2 neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 2 2 2
MIRT635431 LRP10 LDL receptor related protein 10 2 2
MIRT636017 GNPNAT1 glucosamine-phosphate N-acetyltransferase 1 2 2
MIRT636343 PHAX phosphorylated adaptor for RNA export 2 2
MIRT636657 CDK4 cyclin dependent kinase 4 2 2
MIRT637378 HINFP histone H4 transcription factor 2 2
MIRT637727 EXO5 exonuclease 5 2 2
MIRT638580 HYPK huntingtin interacting protein K 2 2
MIRT638611 HIF1AN hypoxia inducible factor 1 alpha subunit inhibitor 2 2
MIRT640797 HEYL hes related family bHLH transcription factor with YRPW motif-like 2 2
MIRT641965 PWWP2A PWWP domain containing 2A 2 2
MIRT642621 CDKN3 cyclin dependent kinase inhibitor 3 2 2
MIRT643125 FAM71F2 family with sequence similarity 71 member F2 2 2
MIRT643352 TRIM10 tripartite motif containing 10 2 2
MIRT643838 PPP5D1 PPP5 tetratricopeptide repeat domain containing 1 2 2
MIRT645613 TSPAN6 tetraspanin 6 2 2
MIRT647206 NPTXR neuronal pentraxin receptor 2 2
MIRT649302 IGSF6 immunoglobulin superfamily member 6 2 2
MIRT650008 KLB klotho beta 2 2
MIRT650166 USHBP1 USH1 protein network component harmonin binding protein 1 2 2
MIRT650441 CPXM2 carboxypeptidase X, M14 family member 2 2 2
MIRT651906 UEVLD UEV and lactate/malate dehyrogenase domains 2 4
MIRT652158 TRIM66 tripartite motif containing 66 2 2
MIRT654719 PRR11 proline rich 11 2 2
MIRT654846 PPM1K protein phosphatase, Mg2+/Mn2+ dependent 1K 2 2
MIRT656063 MTMR10 myotubularin related protein 10 2 2
MIRT657240 IDE insulin degrading enzyme 2 2
MIRT657261 HSPA4L heat shock protein family A (Hsp70) member 4 like 2 2
MIRT659504 CIAO1 cytosolic iron-sulfur assembly component 1 2 2
MIRT660210 BMPR1A bone morphogenetic protein receptor type 1A 2 2
MIRT661075 FFAR2 free fatty acid receptor 2 2 2
MIRT662239 PGBD4 piggyBac transposable element derived 4 2 2
MIRT662336 MYLK3 myosin light chain kinase 3 2 2
MIRT662449 SEMA5A semaphorin 5A 2 2
MIRT662740 LRRC3C leucine rich repeat containing 3C 2 2
MIRT663459 FADS1 fatty acid desaturase 1 2 2
MIRT664177 MYOZ2 myozenin 2 2 2
MIRT664906 PDE6A phosphodiesterase 6A 2 2
MIRT664924 BHMT2 betaine--homocysteine S-methyltransferase 2 2 2
MIRT665528 USP14 ubiquitin specific peptidase 14 2 2
MIRT665534 UROS uroporphyrinogen III synthase 2 2
MIRT666081 SSTR2 somatostatin receptor 2 2 2
MIRT666458 SCRG1 stimulator of chondrogenesis 1 2 2
MIRT668253 FUT11 fucosyltransferase 11 2 2
MIRT668722 DIP2A disco interacting protein 2 homolog A 2 2
MIRT669551 ALG14 ALG14, UDP-N-acetylglucosaminyltransferase subunit 2 2
MIRT670021 TECPR1 tectonin beta-propeller repeat containing 1 2 2
MIRT671098 ZNF665 zinc finger protein 665 2 2
MIRT671479 FLYWCH2 FLYWCH family member 2 2 2
MIRT671495 SLC38A9 solute carrier family 38 member 9 2 2
MIRT672908 KRBA2 KRAB-A domain containing 2 2 2
MIRT675102 SNTB2 syntrophin beta 2 2 2
MIRT676194 GSTM3 glutathione S-transferase mu 3 2 2
MIRT677349 POC1A POC1 centriolar protein A 2 2
MIRT677551 C19orf52 translocase of inner mitochondrial membrane 29 2 2
MIRT677665 UGGT1 UDP-glucose glycoprotein glucosyltransferase 1 2 2
MIRT677689 SCO1 SCO1, cytochrome c oxidase assembly protein 2 2
MIRT678246 FITM2 fat storage inducing transmembrane protein 2 2 2
MIRT678300 GPR155 G protein-coupled receptor 155 2 2
MIRT684176 MOG myelin oligodendrocyte glycoprotein 2 2
MIRT688037 GNE glucosamine (UDP-N-acetyl)-2-epimerase/N-acetylmannosamine kinase 2 2
MIRT689034 ANGPTL3 angiopoietin like 3 2 2
MIRT689618 AKAP6 A-kinase anchoring protein 6 2 2
MIRT691210 KLHL30 kelch like family member 30 2 2
MIRT692300 CNNM3 cyclin and CBS domain divalent metal cation transport mediator 3 2 2
MIRT703556 FKBP14 FK506 binding protein 14 2 2
MIRT709136 GLG1 golgi glycoprotein 1 2 2
MIRT709392 QRFPR pyroglutamylated RFamide peptide receptor 2 2
MIRT711949 SLC7A14 solute carrier family 7 member 14 2 2
MIRT712590 ADCYAP1 adenylate cyclase activating polypeptide 1 2 2
MIRT714007 IL6R interleukin 6 receptor 2 2
MIRT714592 CMBL carboxymethylenebutenolidase homolog 2 2
MIRT716716 SCN7A sodium voltage-gated channel alpha subunit 7 2 2
MIRT718816 PYGO1 pygopus family PHD finger 1 2 2
MIRT719980 MAPK1 mitogen-activated protein kinase 1 2 2
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-4695 Gemcitabine 60750 NSC613327 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4695 Fluorouracil 3385 NSC19893 approved resistant High Pancreatic Cancer cell line (PANC-1)
hsa-mir-4695 Dabrafenib 44462760 NSC764134 approved resistant cell line (A375)
hsa-mir-4695 Androstenedione+Letrozole sensitive cell line (MCF-7)
hsa-miR-4695-3p Fulvestrant 17756771 NSC719276 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-4695-3p Palbociclib 5330286 NSC758247 approved sensitive High Breast Cancer cell line (T47D)
hsa-miR-4695-3p Cisplatin + Decitabine resistant High Non-Small Cell Lung Cancer cell line (A549)
hsa-miR-4695-3p Osimertinib 71496458 NSC779217 approved resistant cell line (PC9)
hsa-miR-4695-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-miR-4695-3p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-4695-3p Neoadjuvant chemotherapy resistant tissue (breast cancer)
hsa-miR-4695-3p Gemcitabine 60750 NSC613327 approved resistant cell line (PANC-1) (1500 ng/ml)
hsa-miR-4695-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-4695-3p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR3)
hsa-miR-4695-3p Gemcitabine 60750 NSC613327 approved resistant cell line (Panc1-GR1)

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