miRTarBase - #MIRT407768


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pre-miRNA Information
pre-miRNA hsa-let-7a-1   
Genomic Coordinates chr9: 94175957 - 94176036
Synonyms LET7A1, MIRNLET7A1, let-7a-1, MIRLET7A1
Description Homo sapiens let-7a-1 stem-loop
Comment let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatible with the genome sequence.
RNA Secondary Structure
Associated Diseases
pre-miRNA hsa-let-7a-3   
Genomic Coordinates chr22: 46112749 - 46112822
Synonyms LET7A3, MIRNLET7A3, let-7a-3, MIRLET7A3
Description Homo sapiens let-7a-3 stem-loop
Comment let-7a-3p cloned in has a 1 nt 3' extension (U), which is incompatible with the genome sequence.
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-let-7a-3p
Sequence 57| CUAUACAAUCUACUGUCUUUC |77
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 5 9 + 94176017 29233923 MiREDiBase
A-to-I 5 22 + 46112804 29233923 MiREDiBase
A-to-I 12 22 + 46112811 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs972845958 1 dbSNP
rs781681931 2 dbSNP
rs748585376 3 dbSNP
rs779353569 6 dbSNP
rs1198423693 8 dbSNP
rs970921980 8 dbSNP
rs372596018 9 dbSNP
rs770208205 10 dbSNP
rs1453867589 11 dbSNP
rs1399588338 15 dbSNP
rs1219969167 16 dbSNP
rs1265084977 18 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol MRPL35   
Synonyms L35mt, MRP-L35
Description mitochondrial ribosomal protein L35
Transcript NM_016622   
Other Transcripts NM_145644   
Expression
Putative miRNA Targets on MRPL35
3'UTR of MRPL35
(miRNA target sites are highlighted)		 
>MRPL35|NM_016622|3'UTR
   1 ATCAGAAGTTTCACTTGTTTCTCAGTTATTGGATATGTATCTTTGTGTACATATCTTTGCAAAAATGGATAAGTACAAAA
  81 CTTGATGTAAATTGTACCAATGAATACGTAAACATACAGTGACAACATTAAACTTAGAAAAGTTTTAAAACTTAATGGAT
 161 CAGACTTTGCCAGATTTGGTTAGGGAAACAGAAATTTAGAATGGTGCATTATTTTTAACAAATGGTATTGGCTTAACTAG
 241 TTGTTTCAGTTATGCTCTTTTAGTTGCAAGGAATCTCAAGTGGGACAAACATAAAAAGACTCAAAAGCTACAAGTTAGCT
 321 CAAGCAATGTGACATTATTTCAAGGATATGTGCCAGGGAATTCAGGAACCACCTCACCAACCCCATCTCCCACTCAGAAA
 401 TCACCTCCCAGCCTCAGGAAGAGTAGAAATTGGGTGGTGCTCCTCAGCAGGGGAAGGTGGATGTTTAGGCTTGGGCTCTG
 481 CATGCATGTGACTTGCTTCTTTTTGCATTGTTAACTCCATTCTCTCTATTCACCAACTTCTCTACACAGCTTTTGCATAC
 561 TTACAGTTTCTGTTCCTTTGTAATAACTTTAACTTGCACCTTTGAGGTTCTTTTCTACATGATGACCTTCAGCTCCTGCT
 641 GCTAGTCTCCAATTGCCAAGGGAATTTAACTGGGCCAGACTACCTTTTTATACTAGGTCTGGTTGGGTCATTGTCTAGAG
 721 TAGGGATTGGCTGTCCTTAAGTCAGGAGCCCGCTTTGTATTAGCAGGTTTGCATGCAGCAAAAAAACAGTTATGTGAGCA
 801 GTTTCACTTGGAGGTTCACATGGGGTGGCAGCACACTTAACATCTAACACACCAGGTTCATTGTGTTCATAACACTTGTC
 881 ATTTACTGTAACAACATTTTTTCATAGGAGAGTAAATAGCCCTTCAGCATGCTCATTCATGAAACAGAAGAGGCTGTACA
 961 AGTGAAGACAAGGGCTTTTTATGCAAGTTTTGAAAGATAGGTATTTATTTTTTCTAGAGACAGGAGTTTTGCTCTGTTGC
1041 CCAGGCTGGAGTGCAGTGGTGCAATCATAGCTCATTGAAGCCTCGCACTCCTGGGCTCAAGTGGTCCTCCTGCCTCAGCT
1121 TACTGAGTAAGGATATGTATTTCTTAAAAGTTAGTTTATCCACTTCAGATTTCATGTTTTCATTTGTAAGGATAAACTTT
1201 TCCCACAAATTTTCAACAATCATTGTAGAAACTAAGGGGGAGAAAGTAATCTCAGTTGTTTTAGAAACGAAAAAGTTAAG
1281 CATTGTTTACTTGAAGTGGGCAGGGAAGCAGCACTGAGTAAAGTTCAATTGAGTGGTTACAGTCTAGGGCAGTGGTTCCC
1361 AACTCTCCGATCAGAATCATCTGGGAAGCATTTTCAAACAGCAAAGTACTTTGAAAACCATTATTAAATAGAATTATGCA
1441 TGAATTACTGTTTCAGATCCTTTAATGTGGTAGTTGGTAATAATAAGATGAAATTCCTCTGTTGTTAGTAAAATTATGAA
1521 ATTGAAGTTCTGCAGCATGTCAGGCCAGGATTATTAGGGAGATTCCTCGAAACTAGTGTGTGTTTATTAAAAGGAGAAAG
1601 GATAACAATAGAATGTTCTAAAACCAGAAGTCCAAGTGCGTGTCTACTTATGGGACCAATAAATAAAGAACAGACATTTG
1681 ATTTGAGGTGAGGTAAAAGCCTGAAACATGGAATGGCATTCTGTTTTGATGGATTTTCATTTCTTCGCACTTCTGAGACG
1761 GCAAAGCCAACCACTTAGAAGCCTTCCACATCTTTGTCACCTGCCTGGCTCCTGCTCTCTGATGTACCTCTGGGTAGTGA
1841 GATGGAAATGGTGCCTGCAGAAGTTGGGGAGAAGGATACTTTTGCACAGCCTCCATGATGTCTTTATTGCAAATATGGAT
1921 GACAAGGGTCTCTGTTACAGGGGCCTCAGAGCACCTTCGTTTCTCCTCTAGACCAGGGACAGGTGTAGAGATAAGGACTG
2001 GCAACCAGAGCCTCAGCATCCAAAGATGGACTGAAGTGGGATGGCTGACAGGCACATAACTTACGGGAAAGGGAATTTCA
2081 TACATACGATTTTTGTTTTGTGGGTAGGAGGGCTTATCATCAACACTGATTTTATAATCTGACAATAAATGTCTTTCATT
2161 AAAGAGTTTACCTAAATGATGTTCGATTATATGTATAATTTATAAAATATTTATGTATAGTTTGTTTATTCAGGTATATG
2241 TATAATTTATTGAACACCTACTATGTCCCAGCATATCTACAAAACTGGGTACATACATACTGTCTAACTGCTAATCCACA
2321 TTTCCAGTCTTACAAAGGACATAATGATTAGTTAAGCCCTAATTTAGATTTGAGGAAACTGAAGCTGAGAGAGGGTTAAG
2401 TAAATTACCCAAAGTACAGCTAATAAGACCCAGAATCTCAGTCTCACTCCTTGGGATCCTGTGTATTTCCCTGAGTCTTC
2481 TAACATATGAAAATTCATATCTAAATCAACAAGTGACTGTAATCTGGTACTATAAATACTAAATAAACACTTCTTCATAA
2561 CACTGTACCAATTCAGCTTTTAAATTTTATTACTTTGCTTTCCTGTCCTTTGCCAACTCTTAACCTAGTTAATCCTAGTT
2641 CTGTTGACATTGGACCAGGCTCAGTAAATAAACGAATGGATTTCCAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' cuUUCUGUCAUC-----UAACAUAuc 5'
            ||| ||| ||      ||||||  
Target 5' ttAAGTCAGGAGCCCGCTTTGTATta 3'
 737 - 762 135.00 -6.50
2 
miRNA  3' cuuUCUGU-CAU-CUAACAUAUc 5'
             :||:| |||   ||||:|| 
Target 5' attGGATATGTATCTTTGTGTAc 3'
 28 - 50 134.00 -7.50
3 
miRNA  3' cuUUCUGU----CAUCUAACAUAuc 5'
            || |||    ||  |||||:|  
Target 5' ctAACACACCAGGTTCATTGTGTtc 3'
 844 - 868 121.00 -6.50
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30191868 26 COSMIC
COSN30107224 46 COSMIC
COSN31596496 46 COSMIC
COSN30119794 47 COSMIC
COSN31585405 56 COSMIC
COSN31554695 73 COSMIC
COSN31610170 75 COSMIC
COSN30528456 104 COSMIC
COSN21509399 105 COSMIC
COSN17519851 159 COSMIC
COSN20708111 325 COSMIC
COSN26882339 527 COSMIC
COSN17182000 551 COSMIC
COSN20288802 753 COSMIC
COSN15845920 845 COSMIC
COSN1861527 899 COSMIC
COSN21676554 1269 COSMIC
COSN30130404 1570 COSMIC
COSN30121342 1606 COSMIC
COSN23664167 1628 COSMIC
COSN14011083 1640 COSMIC
COSN14011085 1651 COSMIC
COSN31601654 1663 COSMIC
COSN30456935 1688 COSMIC
COSN30643764 1688 COSMIC
COSN30132826 1707 COSMIC
COSN509506 1722 COSMIC
COSN30495340 1727 COSMIC
COSN2375771 1728 COSMIC
COSN31524633 1744 COSMIC
COSN30478354 1779 COSMIC
COSN30526218 1779 COSMIC
COSN30598662 1791 COSMIC
COSN30462666 1850 COSMIC
COSN31534049 1867 COSMIC
COSN31612722 1885 COSMIC
COSN7995298 2065 COSMIC
COSN28213397 2186 COSMIC
COSN25761714 2462 COSMIC
COSN31544260 2594 COSMIC
COSN10009544 2618 COSMIC
COSN30173470 2640 COSMIC
COSN28707673 2646 COSMIC
COSN28201269 2900 COSMIC
COSN26633898 2928 COSMIC
COSN30098554 2939 COSMIC
COSN30549917 2974 COSMIC
COSN24388965 3012 COSMIC
COSN17351635 3095 COSMIC
rs2241432 356 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs746061302 1 dbSNP
rs1311254351 2 dbSNP
rs1355113863 6 dbSNP
rs770352962 10 dbSNP
rs775708000 15 dbSNP
rs1196932707 18 dbSNP
rs937390505 22 dbSNP
rs1227359608 25 dbSNP
rs770185839 33 dbSNP
rs773401586 38 dbSNP
rs749610589 41 dbSNP
rs769049845 45 dbSNP
rs917369781 46 dbSNP
rs1189444926 48 dbSNP
rs774883195 49 dbSNP
rs761334598 51 dbSNP
rs1171091944 52 dbSNP
rs1242257895 54 dbSNP
rs373806421 55 dbSNP
rs550173102 66 dbSNP
rs1041728213 70 dbSNP
rs1439933884 74 dbSNP
rs568472177 77 dbSNP
rs1329185234 78 dbSNP
rs3209609 81 dbSNP
rs1272093447 82 dbSNP
rs903078828 95 dbSNP
rs1052078 98 dbSNP
rs534199791 101 dbSNP
rs13353 108 dbSNP
rs1054666836 117 dbSNP
rs753312269 135 dbSNP
rs1173347310 139 dbSNP
rs946945014 143 dbSNP
rs1234999127 166 dbSNP
rs1422588713 182 dbSNP
rs148364811 190 dbSNP
rs902663654 194 dbSNP
rs934194723 195 dbSNP
rs1280572157 220 dbSNP
rs1369396265 223 dbSNP
rs1342610091 226 dbSNP
rs1050860044 239 dbSNP
rs142669665 250 dbSNP
rs566783793 253 dbSNP
rs1166340480 256 dbSNP
rs777061097 258 dbSNP
rs1370219981 261 dbSNP
rs1416729543 264 dbSNP
rs1376191045 270 dbSNP
rs1006646980 275 dbSNP
rs1029412374 278 dbSNP
rs955138511 283 dbSNP
rs540079423 291 dbSNP
rs1003864310 294 dbSNP
rs994084461 302 dbSNP
rs1159521429 308 dbSNP
rs1352183304 318 dbSNP
rs1410439822 322 dbSNP
rs1015278005 328 dbSNP
rs189902070 332 dbSNP
rs1257687459 336 dbSNP
rs981715718 349 dbSNP
rs558731181 353 dbSNP
rs2241432 356 dbSNP
rs778322834 371 dbSNP
rs1224164757 393 dbSNP
rs959407416 402 dbSNP
rs532316692 409 dbSNP
rs1246764624 410 dbSNP
rs1235098471 418 dbSNP
rs920723145 419 dbSNP
rs958860235 424 dbSNP
rs1283727879 426 dbSNP
rs765570427 439 dbSNP
rs1347183931 440 dbSNP
rs991649668 455 dbSNP
rs1319346090 464 dbSNP
rs917317428 470 dbSNP
rs968477807 471 dbSNP
rs1167732991 478 dbSNP
rs950157918 483 dbSNP
rs978366478 487 dbSNP
rs924224743 488 dbSNP
rs1276152749 493 dbSNP
rs934270802 497 dbSNP
rs1216128421 506 dbSNP
rs1464245036 508 dbSNP
rs1266082297 511 dbSNP
rs146749477 523 dbSNP
rs1200361706 524 dbSNP
rs1257531086 525 dbSNP
rs924647745 526 dbSNP
rs1425883373 562 dbSNP
rs878940443 562 dbSNP
rs1289154184 564 dbSNP
rs1226711987 565 dbSNP
rs911411983 570 dbSNP
rs942399455 571 dbSNP
rs555701177 584 dbSNP
rs1363452135 589 dbSNP
rs1328364144 591 dbSNP
rs763187503 597 dbSNP
rs1349843196 601 dbSNP
rs1389717206 606 dbSNP
rs1163408481 610 dbSNP
rs898144797 613 dbSNP
rs1421072033 614 dbSNP
rs1186734713 618 dbSNP
rs1448558536 620 dbSNP
rs755743188 624 dbSNP
rs372622357 641 dbSNP
rs1450324522 646 dbSNP
rs899783501 653 dbSNP
rs1468825851 667 dbSNP
rs1264815329 669 dbSNP
rs1046967400 681 dbSNP
rs907080606 683 dbSNP
rs1273874265 697 dbSNP
rs1002792824 700 dbSNP
rs1306036552 711 dbSNP
rs1034119857 714 dbSNP
rs766931412 719 dbSNP
rs958543505 729 dbSNP
rs779588153 730 dbSNP
rs1445070534 732 dbSNP
rs1355755733 741 dbSNP
rs1168689390 742 dbSNP
rs1012270731 752 dbSNP
rs79849456 753 dbSNP
rs1402854293 767 dbSNP
rs754486323 768 dbSNP
rs1266457908 772 dbSNP
rs890855695 773 dbSNP
rs556041820 776 dbSNP
rs541471869 788 dbSNP
rs1189385061 789 dbSNP
rs532827614 790 dbSNP
rs560601265 794 dbSNP
rs117827858 799 dbSNP
rs748766989 808 dbSNP
rs1318300846 809 dbSNP
rs17438451 810 dbSNP
rs564726899 811 dbSNP
rs955790105 829 dbSNP
rs1299425931 835 dbSNP
rs995620746 846 dbSNP
rs911380912 848 dbSNP
rs1027896775 853 dbSNP
rs1038122434 854 dbSNP
rs76900006 861 dbSNP
rs550287082 864 dbSNP
rs1314299001 876 dbSNP
rs1247790689 889 dbSNP
rs755738209 896 dbSNP
rs1024444373 905 dbSNP
rs1173701745 906 dbSNP
rs971424732 906 dbSNP
rs1047129012 908 dbSNP
rs1412652708 910 dbSNP
rs1181432277 913 dbSNP
rs1482099865 929 dbSNP
rs977540502 931 dbSNP
rs1003172920 934 dbSNP
rs1055665132 935 dbSNP
rs1176904826 938 dbSNP
rs894312027 946 dbSNP
rs1378067271 947 dbSNP
rs1218419815 958 dbSNP
rs1011400134 973 dbSNP
rs1470913543 997 dbSNP
rs1288243680 1002 dbSNP
rs1227133657 1005 dbSNP
rs531017935 1007 dbSNP
rs1021423688 1012 dbSNP
rs1396184165 1015 dbSNP
rs1401094096 1027 dbSNP
rs1300815971 1033 dbSNP
rs1318528080 1036 dbSNP
rs1389163057 1052 dbSNP
rs1387610208 1053 dbSNP
rs924566301 1058 dbSNP
rs936012282 1059 dbSNP
rs568614348 1064 dbSNP
rs1322089126 1065 dbSNP
rs774261603 1067 dbSNP
rs1385675637 1068 dbSNP
rs114195557 1076 dbSNP
rs1188337090 1077 dbSNP
rs1423421969 1081 dbSNP
rs59004051 1083 dbSNP
rs1313505656 1084 dbSNP
rs777254599 1085 dbSNP
rs1031392329 1086 dbSNP
rs749133889 1089 dbSNP
rs1267967951 1096 dbSNP
rs987034635 1100 dbSNP
rs1018575827 1101 dbSNP
rs964197666 1115 dbSNP
rs1244914911 1129 dbSNP
rs756946114 1134 dbSNP
rs1310102395 1137 dbSNP
rs549533517 1140 dbSNP
rs932574711 1151 dbSNP
rs1050888126 1164 dbSNP
rs547805539 1169 dbSNP
rs1319655987 1171 dbSNP
rs1210999035 1175 dbSNP
rs1455510220 1182 dbSNP
rs1245145686 1193 dbSNP
rs182521058 1205 dbSNP
rs1192062698 1206 dbSNP
rs1269544251 1207 dbSNP
rs1471680518 1218 dbSNP
rs982563869 1222 dbSNP
rs1172798464 1226 dbSNP
rs939714747 1233 dbSNP
rs1450387223 1240 dbSNP
rs1247725363 1241 dbSNP
rs928273600 1246 dbSNP
rs1268642810 1252 dbSNP
rs1411189594 1259 dbSNP
rs1457529792 1266 dbSNP
rs1036781179 1269 dbSNP
rs938372706 1270 dbSNP
rs17027032 1280 dbSNP
rs1372972979 1305 dbSNP
rs1324089332 1309 dbSNP
rs1457088677 1312 dbSNP
rs1293809926 1313 dbSNP
rs768917463 1315 dbSNP
rs1407493582 1316 dbSNP
rs1033785402 1326 dbSNP
rs894704883 1327 dbSNP
rs1013134107 1329 dbSNP
rs373996036 1332 dbSNP
rs1230553568 1361 dbSNP
rs1455833106 1363 dbSNP
rs1378646868 1367 dbSNP
rs1024393756 1369 dbSNP
rs187176988 1370 dbSNP
rs1264567854 1384 dbSNP
rs138870121 1389 dbSNP
rs1000006173 1392 dbSNP
rs1031110257 1397 dbSNP
rs1273435200 1403 dbSNP
rs555838137 1405 dbSNP
rs574220543 1421 dbSNP
rs1031743573 1422 dbSNP
rs1346853125 1427 dbSNP
rs891117674 1432 dbSNP
rs1232370311 1435 dbSNP
rs80030533 1437 dbSNP
rs1348948890 1441 dbSNP
rs990143409 1445 dbSNP
rs1370076488 1451 dbSNP
rs921280207 1457 dbSNP
rs192903152 1466 dbSNP
rs986721389 1467 dbSNP
rs1403280798 1470 dbSNP
rs912524044 1474 dbSNP
rs1172371610 1475 dbSNP
rs939864046 1478 dbSNP
rs866106643 1488 dbSNP
rs75197218 1492 dbSNP
rs919666444 1494 dbSNP
rs1366084205 1499 dbSNP
rs546481687 1508 dbSNP
rs564665729 1509 dbSNP
rs571868281 1529 dbSNP
rs866707265 1536 dbSNP
rs1178943780 1546 dbSNP
rs1411337671 1552 dbSNP
rs1250516590 1557 dbSNP
rs931071436 1559 dbSNP
rs1027536471 1562 dbSNP
rs1443801269 1569 dbSNP
rs576704914 1570 dbSNP
rs1199684045 1578 dbSNP
rs1342669577 1579 dbSNP
rs538948177 1583 dbSNP
rs894821052 1603 dbSNP
rs776782035 1606 dbSNP
rs1045958724 1607 dbSNP
rs1286543353 1610 dbSNP
rs544056345 1616 dbSNP
rs1367079727 1619 dbSNP
rs1333869875 1621 dbSNP
rs556534160 1626 dbSNP
rs1387649683 1627 dbSNP
rs1306880507 1633 dbSNP
rs562146242 1636 dbSNP
rs1160550179 1638 dbSNP
rs999015606 1641 dbSNP
rs574932283 1647 dbSNP
rs1179397143 1657 dbSNP
rs147260650 1658 dbSNP
rs1282995306 1659 dbSNP
rs369952992 1672 dbSNP
rs1186446915 1674 dbSNP
rs1440476304 1677 dbSNP
rs765281200 1677 dbSNP
rs957447952 1678 dbSNP
rs1269847654 1681 dbSNP
rs1012083663 1690 dbSNP
rs529422375 1707 dbSNP
rs766993450 1709 dbSNP
rs1028290458 1710 dbSNP
rs1172842732 1712 dbSNP
rs772891080 1714 dbSNP
rs760316296 1716 dbSNP
rs766252777 1719 dbSNP
rs753587594 1725 dbSNP
rs1382117307 1729 dbSNP
rs749570918 1731 dbSNP
rs1442449973 1733 dbSNP
rs1309835226 1739 dbSNP
rs1232537035 1743 dbSNP
rs754733543 1747 dbSNP
rs369047803 1748 dbSNP
rs752628183 1749 dbSNP
rs200636660 1751 dbSNP
rs781421643 1756 dbSNP
rs148722474 1760 dbSNP
rs756306587 1761 dbSNP
rs116387151 1762 dbSNP
rs377489475 1763 dbSNP
rs1395471159 1765 dbSNP
rs1435516790 1769 dbSNP
rs1043008502 1772 dbSNP
rs1175792754 1777 dbSNP
rs1343694737 1778 dbSNP
rs1413971383 1779 dbSNP
rs769018540 1782 dbSNP
rs760020209 1787 dbSNP
rs774888476 1790 dbSNP
rs1162265839 1794 dbSNP
rs1471611675 1798 dbSNP
rs1217377429 1805 dbSNP
rs1257972620 1806 dbSNP
rs748624115 1810 dbSNP
rs1189008201 1813 dbSNP
rs931042842 1824 dbSNP
rs377120146 1829 dbSNP
rs572870297 1837 dbSNP
rs370010378 1838 dbSNP
rs1322403718 1839 dbSNP
rs1289320129 1840 dbSNP
rs1226767860 1844 dbSNP
rs752167744 1852 dbSNP
rs1298744769 1854 dbSNP
rs1046071730 1865 dbSNP
rs1411194793 1869 dbSNP
rs1363514465 1878 dbSNP
rs1008318309 1880 dbSNP
rs1332729402 1880 dbSNP
rs1349894182 1891 dbSNP
rs907429235 1892 dbSNP
rs537629463 1915 dbSNP
rs1053258079 1919 dbSNP
rs1449135759 1929 dbSNP
rs893299027 1930 dbSNP
rs1018264502 1933 dbSNP
rs1422316421 1933 dbSNP
rs1168895141 1945 dbSNP
rs899843902 1953 dbSNP
rs1388165388 1959 dbSNP
rs549599841 1960 dbSNP
rs1488774871 1961 dbSNP
rs371726836 1964 dbSNP
rs1027260272 1971 dbSNP
rs1227923303 1974 dbSNP
rs1298666916 1975 dbSNP
rs567784819 1978 dbSNP
rs1275581871 1982 dbSNP
rs1341519952 1992 dbSNP
rs535561644 2001 dbSNP
rs1340461261 2009 dbSNP
rs185460003 2012 dbSNP
rs553361073 2016 dbSNP
rs1220249241 2032 dbSNP
rs1276350352 2033 dbSNP
rs188722011 2036 dbSNP
rs1402533590 2041 dbSNP
rs1210820212 2043 dbSNP
rs1371915722 2047 dbSNP
rs1308260638 2050 dbSNP
rs1004352221 2063 dbSNP
rs376714072 2063 dbSNP
rs370852770 2065 dbSNP
rs959760053 2066 dbSNP
rs1187509460 2082 dbSNP
rs961288155 2084 dbSNP
rs1197237955 2085 dbSNP
rs753184979 2086 dbSNP
rs973067335 2088 dbSNP
rs1252701331 2089 dbSNP
rs1204628636 2105 dbSNP
rs1390439629 2114 dbSNP
rs1258091497 2118 dbSNP
rs1211287260 2142 dbSNP
rs558465692 2151 dbSNP
rs149405113 2152 dbSNP
rs991214476 2161 dbSNP
rs1230847350 2165 dbSNP
rs1351788753 2179 dbSNP
rs753368283 2186 dbSNP
rs1424999946 2193 dbSNP
rs915565592 2194 dbSNP
rs1370769003 2198 dbSNP
rs919730910 2204 dbSNP
rs952650747 2211 dbSNP
rs968379608 2219 dbSNP
rs990646682 2232 dbSNP
rs916316831 2233 dbSNP
rs543995337 2251 dbSNP
rs562289852 2259 dbSNP
rs1181588470 2264 dbSNP
rs981716106 2280 dbSNP
rs1386877819 2282 dbSNP
rs1417501509 2283 dbSNP
rs1258500633 2286 dbSNP
rs1182707452 2298 dbSNP
rs1483128675 2305 dbSNP
rs1434874627 2312 dbSNP
rs1211066767 2318 dbSNP
rs753224572 2321 dbSNP
rs1268165723 2329 dbSNP
rs1051566080 2334 dbSNP
rs1314667755 2337 dbSNP
rs1314425547 2358 dbSNP
rs757145763 2359 dbSNP
rs911745834 2369 dbSNP
rs116091576 2386 dbSNP
rs1437136309 2393 dbSNP
rs1389314014 2406 dbSNP
rs893425667 2412 dbSNP
rs1328442816 2415 dbSNP
rs1158394012 2422 dbSNP
rs1039837232 2450 dbSNP
rs947525466 2459 dbSNP
rs1049947847 2460 dbSNP
rs1423477402 2462 dbSNP
rs889849445 2467 dbSNP
rs193283037 2472 dbSNP
rs1264973556 2485 dbSNP
rs887329305 2486 dbSNP
rs77872016 2498 dbSNP
rs1207903548 2501 dbSNP
rs184783457 2502 dbSNP
rs1244977884 2506 dbSNP
rs960225459 2511 dbSNP
rs1312582547 2513 dbSNP
rs1230305114 2515 dbSNP
rs1012601922 2527 dbSNP
rs1319808464 2540 dbSNP
rs879185852 2543 dbSNP
rs1380519780 2544 dbSNP
rs994219690 2557 dbSNP
rs968348511 2565 dbSNP
rs1457559903 2566 dbSNP
rs978417017 2567 dbSNP
rs1170771335 2569 dbSNP
rs750434412 2571 dbSNP
rs1191592823 2572 dbSNP
rs551513120 2588 dbSNP
rs1268790546 2589 dbSNP
rs1245611883 2590 dbSNP
rs1209933448 2599 dbSNP
rs1490056985 2617 dbSNP
rs1478095655 2619 dbSNP
rs911712800 2623 dbSNP
rs943205143 2633 dbSNP
rs3087642 2646 dbSNP
rs1410437913 2647 dbSNP
rs1296621739 2648 dbSNP
rs1225069057 2657 dbSNP
rs1456997377 2659 dbSNP
rs1302014388 2662 dbSNP
rs144717476 2674 dbSNP
rs73946347 2675 dbSNP
rs1403805094 2691 dbSNP
rs1166546150 2698 dbSNP
rs1479260470 2699 dbSNP
rs577065658 2700 dbSNP
rs1198823002 2703 dbSNP
rs567919700 2718 dbSNP
rs771126791 2720 dbSNP
rs528943596 2724 dbSNP
rs1479819517 2725 dbSNP
rs779754039 2731 dbSNP
rs923755510 2734 dbSNP
rs1406879443 2746 dbSNP
rs1483182961 2760 dbSNP
rs934985098 2761 dbSNP
rs1193880393 2767 dbSNP
rs989192729 2769 dbSNP
rs1256485723 2777 dbSNP
rs914792706 2778 dbSNP
rs1222900552 2785 dbSNP
rs1343654736 2792 dbSNP
rs1290295883 2797 dbSNP
rs1004457509 2798 dbSNP
rs1057340190 2803 dbSNP
rs895986179 2810 dbSNP
rs1416485267 2813 dbSNP
rs1403434581 2825 dbSNP
rs12468666 2830 dbSNP
rs947634930 2836 dbSNP
rs1468717308 2845 dbSNP
rs1426509198 2854 dbSNP
rs1183758950 2856 dbSNP
rs1227481360 2858 dbSNP
rs1472688280 2860 dbSNP
rs1231934307 2864 dbSNP
rs1179273246 2866 dbSNP
rs117498941 2869 dbSNP
rs1256611010 2872 dbSNP
rs188019019 2876 dbSNP
rs1013073764 2878 dbSNP
rs1023095664 2888 dbSNP
rs1229056689 2906 dbSNP
rs148117880 2909 dbSNP
rs1303064594 2912 dbSNP
rs1000370968 2913 dbSNP
rs774621247 2915 dbSNP
rs944062547 2916 dbSNP
rs1235996133 2918 dbSNP
rs771635310 2919 dbSNP
rs1041523724 2925 dbSNP
rs1316024630 2927 dbSNP
rs11944 2928 dbSNP
rs1261973977 2929 dbSNP
rs1467037908 2930 dbSNP
rs760118260 2938 dbSNP
rs1253352377 2943 dbSNP
rs1455396523 2963 dbSNP
rs59150256 2964 dbSNP
rs888335449 2966 dbSNP
rs528911659 2967 dbSNP
rs987365342 2969 dbSNP
rs1457282551 2970 dbSNP
rs537743962 2972 dbSNP
rs555955291 2973 dbSNP
rs770997589 2974 dbSNP
rs1347093891 2980 dbSNP
rs1023387053 2983 dbSNP
rs1182780108 2985 dbSNP
rs1459850982 2986 dbSNP
rs970532618 2989 dbSNP
rs771380680 2995 dbSNP
rs1018910963 2996 dbSNP
rs1209348004 2999 dbSNP
rs759269483 3006 dbSNP
rs774673966 3011 dbSNP
rs563658035 3017 dbSNP
rs141828679 3018 dbSNP
rs1169952612 3020 dbSNP
rs956508390 3022 dbSNP
rs1372155683 3025 dbSNP
rs1314744500 3027 dbSNP
rs1391755047 3046 dbSNP
rs760073205 3053 dbSNP
rs1321803562 3074 dbSNP
rs1430718389 3075 dbSNP
rs116080175 3083 dbSNP
rs1306262234 3084 dbSNP
rs553410910 3087 dbSNP
rs920445915 3108 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... PAR-CLIP data was present in GSM545216. RNA binding protein: AGO2. Condition:miR-124 transfection ...

- Hafner M; Landthaler M; Burger L; Khorshid et al., 2010, Cell.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' cuuUCUGUCAUCUAACAUAUc 5'
             ||::| ||   |||||| 
Target 5' uucAGGUA-UA---UGUAUAa 3'
 		5 - 21
Article - Hafner M; Landthaler M; Burger L; Khorshid et al.
- Cell, 2010
RNA transcripts are subject to posttranscriptional gene regulation involving hundreds of RNA-binding proteins (RBPs) and microRNA-containing ribonucleoprotein complexes (miRNPs) expressed in a cell-type dependent fashion. We developed a cell-based crosslinking approach to determine at high resolution and transcriptome-wide the binding sites of cellular RBPs and miRNPs. The crosslinked sites are revealed by thymidine to cytidine transitions in the cDNAs prepared from immunopurified RNPs of 4-thiouridine-treated cells. We determined the binding sites and regulatory consequences for several intensely studied RBPs and miRNPs, including PUM2, QKI, IGF2BP1-3, AGO/EIF2C1-4 and TNRC6A-C. Our study revealed that these factors bind thousands of sites containing defined sequence motifs and have distinct preferences for exonic versus intronic or coding versus untranslated transcript regions. The precise mapping of binding sites across the transcriptome will be critical to the interpretation of the rapidly emerging data on genetic variation between individuals and how these variations contribute to complex genetic diseases.
LinkOut: [PMID: 20371350]
CLIP-seq Support 1 for dataset GSM545216
Method / RBP PAR-CLIP / AGO2
Cell line / Condition HEK293 / miR-124 transfection
Location of target site ENST00000337109.4 | 3UTR | UUUAUUCAGGUAUAUGUAUAAUUUAUUGAACACCUACU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 20371350 / GSE21578
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BLCA -0.611 0 -0.659 0 18 Click to see details
UCEC -0.483 0.02 -0.374 0.06 19 Click to see details
PRAD -0.253 0.04 -0.167 0.12 50 Click to see details
KIRP -0.271 0.07 -0.257 0.08 32 Click to see details
CESC -0.957 0.09 -0.500 0.33 3 Click to see details
COAD -0.769 0.12 -1.000 0.5 4 Click to see details
THCA 0.154 0.12 0.155 0.12 59 Click to see details
LUSC -0.178 0.14 -0.175 0.15 38 Click to see details
ESCA 0.303 0.18 0.336 0.16 11 Click to see details
KICH -0.174 0.2 -0.072 0.37 25 Click to see details
LIHC -0.104 0.24 -0.023 0.44 49 Click to see details
LUAD 0.212 0.25 0.203 0.26 12 Click to see details
BRCA -0.068 0.27 -0.087 0.22 84 Click to see details
STAD 0.105 0.28 0.104 0.29 32 Click to see details
CHOL 0.208 0.3 0.033 0.47 9 Click to see details
HNSC -0.051 0.37 -0.061 0.35 42 Click to see details
PAAD 0.203 0.4 0.400 0.3 4 Click to see details
PCPG 0.27 0.41 0.500 0.33 3 Click to see details
KIRC 0.024 0.42 0.041 0.37 68 Click to see details
KIRC 0.024 0.42 0.041 0.37 68 Click to see details
121 hsa-let-7a-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT038998 ARMC8 armadillo repeat containing 8 1 1
MIRT038999 SETD4 SET domain containing 4 1 1
MIRT039000 BTF3 basic transcription factor 3 1 1
MIRT039001 MIPOL1 mirror-image polydactyly 1 1 1
MIRT039002 TRIM33 tripartite motif containing 33 1 1
MIRT039003 CS citrate synthase 1 1
MIRT039004 SENP7 SUMO1/sentrin specific peptidase 7 1 1
MIRT055418 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 10
MIRT057681 LCOR ligand dependent nuclear receptor corepressor 2 8
MIRT061351 WEE1 WEE1 G2 checkpoint kinase 2 2
MIRT062174 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT071813 RNF11 ring finger protein 11 2 2
MIRT091374 EIF4A2 eukaryotic translation initiation factor 4A2 2 2
MIRT095107 SEC24A SEC24 homolog A, COPII coat complex component 2 2
MIRT098814 PPIL4 peptidylprolyl isomerase like 4 2 2
MIRT109534 KLHL15 kelch like family member 15 2 4
MIRT120263 GSK3B glycogen synthase kinase 3 beta 2 2
MIRT149839 LDLR low density lipoprotein receptor 2 6
MIRT164519 MSMO1 methylsterol monooxygenase 1 2 2
MIRT165879 CREBRF CREB3 regulatory factor 2 2
MIRT169899 HBP1 HMG-box transcription factor 1 2 4
MIRT182779 TOR1AIP2 torsin 1A interacting protein 2 2 2
MIRT193466 RORA RAR related orphan receptor A 2 2
MIRT226421 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 2
MIRT334410 CREBZF CREB/ATF bZIP transcription factor 2 6
MIRT338286 SYF2 SYF2 pre-mRNA splicing factor 2 2
MIRT361627 TES testin LIM domain protein 2 2
MIRT406687 ZNF181 zinc finger protein 181 2 2
MIRT407768 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT449468 HAT1 histone acetyltransferase 1 2 2
MIRT467110 SRI sorcin 2 2
MIRT475099 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 6
MIRT481671 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT493061 MTFR1 mitochondrial fission regulator 1 2 2
MIRT497923 BTG1 BTG anti-proliferation factor 1 2 2
MIRT498202 ACVR2B activin A receptor type 2B 2 2
MIRT503391 ASB11 ankyrin repeat and SOCS box containing 11 2 6
MIRT503862 UBXN2B UBX domain protein 2B 2 2
MIRT504368 ARID1B AT-rich interaction domain 1B 2 4
MIRT504991 ZNF652 zinc finger protein 652 2 2
MIRT505754 SENP1 SUMO1/sentrin specific peptidase 1 2 8
MIRT518102 ADH1B alcohol dehydrogenase 1B (class I), beta polypeptide 2 6
MIRT521930 PHF8 PHD finger protein 8 2 4
MIRT522139 NRBF2 nuclear receptor binding factor 2 2 6
MIRT522401 MYADM myeloid associated differentiation marker 2 4
MIRT523593 FZD5 frizzled class receptor 5 2 4
MIRT523944 E2F8 E2F transcription factor 8 2 4
MIRT524355 CREB1 cAMP responsive element binding protein 1 2 2
MIRT525140 ZNF256 zinc finger protein 256 2 2
MIRT527070 ABCC4 ATP binding cassette subfamily C member 4 2 2
MIRT527486 OCIAD1 OCIA domain containing 1 2 2
MIRT528129 PPP1R10 protein phosphatase 1 regulatory subunit 10 2 2
MIRT530528 ALG10B ALG10B, alpha-1,2-glucosyltransferase 2 2
MIRT531270 PPIL3 peptidylprolyl isomerase like 3 2 2
MIRT538898 BRI3BP BRI3 binding protein 2 2
MIRT541371 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT541526 MGAT4C MGAT4 family member C 2 2
MIRT543776 RBM12B RNA binding motif protein 12B 2 4
MIRT543946 NCOA7 nuclear receptor coactivator 7 2 2
MIRT545156 GABRG1 gamma-aminobutyric acid type A receptor gamma1 subunit 2 2
MIRT545848 ZNF264 zinc finger protein 264 2 4
MIRT546064 VEZF1 vascular endothelial zinc finger 1 2 2
MIRT546481 SLC16A14 solute carrier family 16 member 14 2 4
MIRT551835 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT551901 ACP1 acid phosphatase 1, soluble 2 2
MIRT552490 ZNF136 zinc finger protein 136 2 2
MIRT554206 SLC35A5 solute carrier family 35 member A5 2 2
MIRT554295 SIPA1L2 signal induced proliferation associated 1 like 2 2 2
MIRT555765 PCTP phosphatidylcholine transfer protein 2 2
MIRT558315 DSG2 desmoglein 2 2 2
MIRT563147 NOLC1 nucleolar and coiled-body phosphoprotein 1 2 2
MIRT566464 PGGT1B protein geranylgeranyltransferase type I subunit beta 2 2
MIRT567322 HMGB2 high mobility group box 2 2 2
MIRT567738 DLX2 distal-less homeobox 2 2 2
MIRT567892 CSTF2 cleavage stimulation factor subunit 2 2 2
MIRT570087 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 2
MIRT571136 TTC33 tetratricopeptide repeat domain 33 2 2
MIRT573534 MDM2 MDM2 proto-oncogene 2 2
MIRT574465 RPS16 ribosomal protein S16 2 2
MIRT574998 Phka1 phosphorylase kinase alpha 1 2 3
MIRT610202 CD99 CD99 molecule (Xg blood group) 2 4
MIRT612926 GPRIN3 GPRIN family member 3 2 2
MIRT615027 DUSP6 dual specificity phosphatase 6 2 2
MIRT617200 GREM1 gremlin 1, DAN family BMP antagonist 2 2
MIRT628720 ZNF585A zinc finger protein 585A 2 2
MIRT641491 POLA2 DNA polymerase alpha 2, accessory subunit 2 2
MIRT641663 PAPOLG poly(A) polymerase gamma 2 2
MIRT642216 RUVBL2 RuvB like AAA ATPase 2 2 2
MIRT654589 PURA purine rich element binding protein A 2 2
MIRT656136 MSH6 mutS homolog 6 2 2
MIRT656899 KIAA2018 upstream transcription factor family member 3 2 2
MIRT660136 BRPF3 bromodomain and PHD finger containing 3 2 2
MIRT660861 AFAP1 actin filament associated protein 1 2 2
MIRT676849 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 3
MIRT681479 DIP2A disco interacting protein 2 homolog A 2 2
MIRT682259 RS1 retinoschisin 1 2 2
MIRT685602 MYOM2 myomesin 2 2 2
MIRT686943 SFT2D3 SFT2 domain containing 3 2 2
MIRT694302 COPB2 coatomer protein complex subunit beta 2 2 2
MIRT694407 ALDH1A3 aldehyde dehydrogenase 1 family member A3 2 2
MIRT697280 ZNF800 zinc finger protein 800 2 2
MIRT698414 TM4SF1 transmembrane 4 L six family member 1 2 2
MIRT698989 SPAG9 sperm associated antigen 9 2 2
MIRT699766 SEMA4D semaphorin 4D 2 2
MIRT699928 RUFY2 RUN and FYVE domain containing 2 2 2
MIRT702113 MBNL1 muscleblind like splicing regulator 1 2 2
MIRT702373 KLF10 Kruppel like factor 10 2 2
MIRT702646 ITGA3 integrin subunit alpha 3 2 2
MIRT705713 ANAPC16 anaphase promoting complex subunit 16 2 2
MIRT717925 ZNF546 zinc finger protein 546 2 2
MIRT720839 C1orf52 chromosome 1 open reading frame 52 2 2
MIRT725033 NDUFAF7 NADH:ubiquinone oxidoreductase complex assembly factor 7 2 2
MIRT731448 APOBEC3A apolipoprotein B mRNA editing enzyme catalytic subunit 3A 1 1
MIRT733217 CCNG1 cyclin G1 2 0
MIRT734887 LIN28B lin-28 homolog B 1 0
MIRT735276 HMGA2 high mobility group AT-hook 2 2 0
MIRT735727 SYNCRIP synaptotagmin binding cytoplasmic RNA interacting protein 3 0
MIRT736087 RCVRN recoverin 1 0
MIRT736088 RHO rhodopsin 1 0
MIRT736103 TLR7 toll like receptor 7 1 0
MIRT736607 TPO thyroid peroxidase 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
let-7a Caudatin NULL 21633059 Quantitative real-time PCR gastric carcinoma cell lines 23708208 2013 up-regualted
let-7a XMD8-92 NULL 46843772 Microarray pancreatic ductal adenocarcinoma cell 24880079 2014 up-regulated
let-7a Hydroxamic acid HDACi LAQ824 NULL NULL Microarray breast cancer cell line SKBr3 16452179 2006 down-regulated
let-7a Hydroxamic acid HDACi LAQ824 NULL NULL Northern blot breast cancer cell line SKBr3 16452180 2006 down-regulated
let-7a Trichostatin A (TSA) NULL 444732 Microarray human pancreatic cancer cell line BxPC-3 19112422 2009 down-regulated
let-7a 17beta-estradiol (E2) approved 5757 Microarray MCF-7 breast cancer cells 19528081 2009 up-regulated
let-7a Etoposide approved 36462 Microarray Normal human fibroblasts (AG01522) 19633716 2009 down-regulated
let-7a Etoposide approved 36462 Quantitative real-time PCR Normal human fibroblasts (AG01522) 19633716 2009 down-regulated
let-7a Polylysine NULL 162282 Quantitative real-time PCR 293T(FLAG AGO2) cells 20529860 2010 down-regulated
let-7a Trypaflavine NULL NULL Quantitative real-time PCR 293T(FLAG AGO2) cells 20529860 2010 down-regulated
let-7a Formaldehyde NULL 712 Microarray Human lung epithelial cells (A549) 21147603 2011 down-regulated
let-7a Enoxacin approved 3229 Northern blot HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
let-7a Enoxacin approved 3229 Quantitative real-time PCR HCT-116 and RKO colon cancer cell lines 21368194 2011 up-regulated
let-7a Metformin approved 4091 Quantitative real-time PCR MCF-7 human mammary cancer cell line 21368581 2011 up-regulated
let-7a 5-Fluorouracil approved 3385 Microarray MCF-7 breast cancer cells 21506117 2011 up-regulated
let-7a Arsenic trioxide approved 14888 Quantitative real-time PCR acute promyelocytic leukemia 22072212 2012 up-regulated
let-7a Metformin approved 4091 Quantitative real-time PCR pancreatic cancer cells 22086681 2012 up-regulated
let-7a Metformin approved 4091 Quantitative real-time PCR pancreatic cancer cells 22086681 2012 up-regulated
let-7a CDF(analogues of curcumin) NULL NULL Quantitative real-time PCR pancreatic cancer cells 22108826 2012 up-regulated
let-7a Marine fungal metabolite 1386A NULL NULL Microarray MCF-7 breast cancer cells. 22159329 2012 down-regulated
let-7a Curcumin NULL 969516 Quantitative real-time PCR esophageal cancer cells 22363450 2012 up-regulated
let-7a 1,2,6-Tri-O-galloyl-beta-D-glucopyranose NULL NULL Microarray HepG2 hepatocarcinoma cells. 22506400 2011 up-regulated
let-7a Vitamin D3 approved 5280795 Quantitative real-time PCR Plasma 22594500 2012 up-regulated
let-7a Hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) NULL 8490 Microarray mouse liver 19270793 2009 down-regulated
let-7a Budesonide approved 5281004 Microarray neonatal mice liver 20145010 2010 up-regulated
let-7a Budesonide approved 5281004 Microarray neonatal mice lung 20145010 2010 down-regulated
let-7a Phenethyl isothiocyanate(PEITC) NULL 16741 Microarray neonatal mice lung 20145010 2010 up-regulated
let-7a Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 down-regulated
let-7a Dexamethasone approved 5743 Quantitative real-time PCR primary rat thymocytes 20847043 2010 down-regulated
let-7a Perfluorooctane sulfonate NULL 74483 Microarray zebrafish embryos 20878907 2011 up-regulated
let-7a Hydroxychloroquine approved 3652 Quantitative real-time PCR mesangial cells 24121037 2013 down-regualted
let-7a Prednisone approved 5865 Quantitative real-time PCR mesangial cells 24121037 2013 down-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-let-7a-3p Gemcitabine 60750 NSC613327 approved resistant High Cholangiocarcinoma cell line (HuCCT1, HuH28)
hsa-let-7a-3p Docetaxel 148124 NSC628503 approved sensitive High Breast Cancer cell line (MDA-MB-231, MCF-7)
hsa-let-7a-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-let-7a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-let-7a-3p Osimertinib 71496458 NSC779217 approved resistant cell line (HCC827)
hsa-let-7a-3p Vemurafenib 42611257 NSC761431 approved sensitive cell line (451Lu)
hsa-let-7a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A2780)
hsa-let-7a-3p Fluorouracil 3385 NSC19893 approved sensitive cell line (HCT15)
hsa-let-7a-3p 4-Hydroxytamoxifen+Tamoxifen resistant cell line (LY2)
hsa-let-7a-3p Oxaliplatin 6857599 NSC266046 approved resistant cell line (IGROV-1)
hsa-let-7a-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-let-7a-3p Neoadjuvant chemotherapy sensitive tissue (breast cancer)
hsa-let-7a-3p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide sensitive cell line (Bads-200)

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