miRTarBase - #MIRT439294


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pre-miRNA Information
pre-miRNA hsa-mir-539   
Genomic Coordinates chr14: 101047321 - 101047398
Synonyms MIRN539, hsa-mir-539, MIR539
Description Homo sapiens miR-539 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-539-5p
Sequence 9| GGAGAAAUUAUCCUUGGUGUGU |30
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 10 14 + 101047338 22499667, 26449202, 27229138, 28550310, 29165639, 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs920592001 1 dbSNP
rs949143380 2 dbSNP
rs1037241141 4 dbSNP
rs1261686093 10 dbSNP
rs747290147 19 dbSNP
rs1397145918 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol WASF3   
Synonyms Brush-1, SCAR3, WAVE3
Description WAS protein family member 3
Transcript NM_006646   
Expression
Putative miRNA Targets on WASF3
3'UTR of WASF3
(miRNA target sites are highlighted)		 
>WASF3|NM_006646|3'UTR
   1 GCAAAGGCCGGCGGAGAGGCCGCGTGTGGGAGCGTGTTGAAGATTTTAAGTGGTCTCTACACCCAAATAGTGGTATTCTA
  81 ATCCCGTAGCATAGCACCTTTTGTATAAACAATGTGATATTGCTTCTGCACATCCAAAAATTCTGGGTCTTTTCAGTATT
 161 TACTGTGTAATACTTAAGTGCCACTAAACATAGCAAATTGTGCTGCACATGAGGAAATAGGCTGTCACTATCACATTGTC
 241 CTGAAAACAGCATCTGCTTTCCTCTTGGCCATGAGAGTATTTAGTGCAGTTTGGGTTTACTCTTACTGATCAATATAACT
 321 CTGCAGACTTGCTGTGTGTTTGTGAAGCTGCCTGGTGTTAGGTCTCTGCAAGACTAATGACTATGTCAGAGTGATGTCTT
 401 CCAACCAGTAAGTGATATTGTTTCACCGCTTTGGTTTTTCCTTTTGTTTTTTTAAAGGATGTGTTTCTGAATAAGTTGGT
 481 TTTAGAGGGAAAGGTTCAACAAACAGGGAGAATCCAGTGTTTCTGCTTTCAGTTTCTTGGCTTGGTAGCCTCTGAGTGAA
 561 TCTGATGCTCTGCTGAATAATTTCATTACCTCTGCACATGCCTGTCAAATATGAAATTGGAAGGGCCCTTTTCAGGCTGG
 641 GTTCCCTGTGGGCATTTGCTTAGTAAATGCCTGTTGATGGTTTTTGCAAGAGAATTCAGCAGCTCAACAGTAATGAAAGT
 721 GAAGAACAGAGTCCATTTTCCTTCCTGGGGCCATTGGGGATGACACTCAAGATACTTGCCAGTCTCTCCAGTGTGGGCAC
 801 CAGCCGGCCAGAACAGATGCGAGCAGTCCATGACTCTGGGAGCTACACCGCTGAGCTGGGCAGAGCTGCGGCACAGGGCC
 881 TGGGCTGCAAAGGAGCCCTGCTCCTTTAGTTTCCTGACACCTGTGTCCTGAGTGAGCCGCAGGAGTTCTTAGCTCCTCAG
 961 CGAGCAACAGAGAGCACTTTAGATGGCACCTTTCACCACTTGGTCAGAATTTTAAAAGCTTAGGTTTAGGTGAAAGTAGA
1041 TATTGACAGCTATTCACCTTTCACGGTGCTGGGGCCAGATTAGGGATCACTCCCGTGAGGAGGGCCTTCACCCTGTTCTA
1121 GAAGCACATGGTTGTCCTCCTGTTGTTGGCACATTAAATGATAAAAAGCACCTCATGAGATTCCCTTGATCAGCCCTGCA
1201 GCTGTAGTACAGTGCTGTGCCCTCACCTCCACCCTTCCTGTTGTTCCCACGTGGGCAATACCAGGGACCCATGGGGAAAC
1281 TCAAGAATGACAGCTTCTATATTTTGTAATTCTGGATGAAAGATAACTGTGTTGAACAAACAGGTGCTCCAGGCTTTGAT
1361 TATAGATACGACTTCAAAAATATGCTAAGACGCTTGACTTATTAAGGACTTTAACCTACTCAACAGTATTTCATATCCAT
1441 TGTGGTTAGTTACTCAGTTATGTTGAGAAGAATCTGGAGCTAAAAGCAGAGATGTTTGAGGTGACGGTAGGAATGTGAGC
1521 AGGATGGTGATGGGGGTTTTTGTTAAAATGCATCTGAGCAAGTCAGCCAGCCCCGAAGTCCCCTCAGTGTGTGTGTCTCG
1601 AGTGGCTACCTGTTGGGCTTGTGGGCAGTGATTGTACAGAGCCTGTCCATTGGGTGCAGTCATGTAGATCTGAAGCCCTG
1681 AAAAGCCTCATGTCTGCATCCCCTTTCCAAGGCTGCTTCCCTGGTGTGTCTGTTCTCTCCTCTGTCCCAGGTGCTGGGAG
1761 CGTCCTCTTCAGCGTCTTTTCCTAGAGCTGGTCACCACTAGGCTGTCACTATAAATTCCTTGAATATAAGTAACAGTTAT
1841 TAATGAACTTCTAAATTTCTAATTTCTCTCTCTCTCTCTTTTTTTTTTTTTTGTTGTTGTTAAAAAGGGCCTACTACATT
1921 GGCGCTATTCTTAGGACTTCTGCAACTTTTAAAGTCTTACTTGTCTTTCTTGTTGCTTTTGTATTAGGAGTTCCCCGTGT
2001 GGGTCTAGAACTCCCCTTTGGTAATGCTTCTTTGTTTTTTTATGGCCCTTCTGTTCTCAGGATGGAGAGAACACAGAAGC
2081 TACTATCCATGTCAGGATTTATTCTATTTATATCTTATTACAATAAAATTAGTGGCACTTTATTCATAAATATTCATGAG
2161 CCTGTTAATTGTTAGTTGTCTTCCTGTAGCTGAATCAACAAGTTATTTTCAACTCAATTTTATGACTTGCGAAAAAGCTT
2241 TTGCCCTGTTGTGTACCATAACATTTAAAAGAATGGAAAATGACTGAAATCCAATTTAGATTATTTTTAGAGTATTTTTC
2321 CAGCAAATTCAATTTATTCTGAAATTTAAATCCAGATCTTTTCTAATATGGTATTACAATGAAAAGAATAAAGAGAAGAT
2401 TTGAATTTTCAGTTTCATTTTCAAAAACTATTTACCAAAACAAATGGAGAAGAAACATCCAAAAGCACATTTCATTTCTC
2481 CAAACTTTGTGTTTTAAATTATAGTTATAAATTGTAAGGTAATTTTAAATTGTCCCTCGTATTATTTCTCCACGTCTGTT
2561 TTAGTTTAATGTCTCCTAAGCTTTTCTCTCATAGCGTAGACCTAGGGAAGGGATGGGAAGATTGCCCAGTCCCCGATGGC
2641 TGCGCACACAGGAGGCGGCGGAGCACAAGGCAAGTGAGTTTGCACTGTCAGCCCCAGACCGTAAGCTTGGCTACACTGAT
2721 GTTTTTCTTTACTAAGGATACTATTCAAAAATTAACATTTTCATCTCAGTAAGTTTTTAGAACATCAAAATGTTTTCTGA
2801 GCTCCAAGTGGCTAGGTTGTAAAAGTTTTATAATAATTTGCAATTAAAATACATGATACATATTAATCCATTAAAGACTA
2881 GTGGGAATGTATCAGCCAGAGTAGCAAGTAATTTTTGTTTTATAAATCATAGTATCTGTCATCTTGCAGTATTACCAATG
2961 CTGTTGTAAATTGAATTTAAAGTGGTATTAAAAAAAACTGTTAAACAATTTTTATCTGTTTGTATATCTTACTATAGATT
3041 ATGTACAAGTAACATCTAAATAAAATTACACTTTTAACCCTAAGAGGTTTTGCTTATTAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ugUGUGG---UUCCU----AUUAAAGAGg 5'
            |||:|   ||| |    | ||||||| 
Target 5' aaACATCCAAAAGCACATTTCATTTCTCc 3'
 2453 - 2481 154.00 -12.60
2 
miRNA  3' uguguGGUUCCUAUUAAAGAGg 5'
               ||  | || ||||||| 
Target 5' ttgtcCCTCGTATTATTTCTCc 3'
 2530 - 2551 153.00 -11.30
3 
miRNA  3' ugugugguuccuAUUAAAGAGg 5'
                      ||||||||| 
Target 5' cttctaaatttcTAATTTCTCt 3'
 1848 - 1869 150.00 -7.90
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30516699 10 COSMIC
COSN13436188 11 COSMIC
COSN512133 13 COSMIC
COSN30644177 14 COSMIC
COSN30155638 17 COSMIC
COSN27004808 22 COSMIC
COSN27004806 23 COSMIC
COSN13436190 24 COSMIC
COSN30105713 34 COSMIC
COSN30492475 56 COSMIC
COSN30157524 58 COSMIC
COSN30498999 69 COSMIC
COSN30464245 85 COSMIC
COSN30499036 90 COSMIC
COSN30120820 144 COSMIC
COSN8127745 556 COSMIC
COSN17725672 624 COSMIC
COSN20161947 725 COSMIC
COSN15013725 749 COSMIC
COSN20110456 896 COSMIC
COSN6621157 933 COSMIC
COSN16809282 940 COSMIC
COSN1604850 1214 COSMIC
COSN1604851 1261 COSMIC
COSN21221567 1313 COSMIC
COSN8777858 1446 COSMIC
COSN27588985 1878 COSMIC
COSN27365648 1879 COSMIC
COSN27302592 1880 COSMIC
COSN27487399 1880 COSMIC
COSN20110457 1893 COSMIC
COSN1604852 1894 COSMIC
COSN32058678 1928 COSMIC
COSN27580733 1989 COSMIC
COSN21025594 2009 COSMIC
COSN32089223 2238 COSMIC
COSN28315491 2554 COSMIC
COSN30311302 2645 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1183789495 7 dbSNP
rs558590246 10 dbSNP
rs374018521 11 dbSNP
rs748597431 13 dbSNP
rs772574331 14 dbSNP
rs1432738940 21 dbSNP
rs200376881 22 dbSNP
rs760968762 23 dbSNP
rs960783167 24 dbSNP
rs199731940 25 dbSNP
rs1286752147 26 dbSNP
rs759683384 27 dbSNP
rs1381692781 33 dbSNP
rs376752738 34 dbSNP
rs201025592 35 dbSNP
rs757192091 37 dbSNP
rs991563280 38 dbSNP
rs767381374 43 dbSNP
rs750212174 45 dbSNP
rs1312846215 47 dbSNP
rs769320799 52 dbSNP
rs573871095 57 dbSNP
rs950244936 60 dbSNP
rs541201779 61 dbSNP
rs1232039673 62 dbSNP
rs1364126013 63 dbSNP
rs908757236 66 dbSNP
rs920178380 86 dbSNP
rs773253609 87 dbSNP
rs1038402438 90 dbSNP
rs562681971 91 dbSNP
rs749210259 92 dbSNP
rs1241796542 103 dbSNP
rs982933641 104 dbSNP
rs1207380047 105 dbSNP
rs912693597 108 dbSNP
rs188195511 121 dbSNP
rs932355386 132 dbSNP
rs1361776020 147 dbSNP
rs770954049 152 dbSNP
rs1316008274 154 dbSNP
rs1431598205 168 dbSNP
rs1468286022 172 dbSNP
rs1050791007 174 dbSNP
rs1176418866 179 dbSNP
rs79625024 191 dbSNP
rs1009793451 192 dbSNP
rs564925953 201 dbSNP
rs947058359 208 dbSNP
rs1327297208 210 dbSNP
rs1385648289 215 dbSNP
rs775732549 219 dbSNP
rs1436806524 231 dbSNP
rs1367002825 234 dbSNP
rs1163865471 238 dbSNP
rs1423652448 244 dbSNP
rs1382831366 247 dbSNP
rs903735183 257 dbSNP
rs1429625586 262 dbSNP
rs903118679 263 dbSNP
rs998731578 265 dbSNP
rs1292721024 278 dbSNP
rs1222373178 280 dbSNP
rs111542114 284 dbSNP
rs1341409019 288 dbSNP
rs895644475 290 dbSNP
rs41291666 303 dbSNP
rs567184683 311 dbSNP
rs1254326781 313 dbSNP
rs148603085 314 dbSNP
rs1380274883 316 dbSNP
rs983319526 317 dbSNP
rs144226592 329 dbSNP
rs1423590424 333 dbSNP
rs1271311542 335 dbSNP
rs908710251 356 dbSNP
rs1169075207 361 dbSNP
rs1479540230 365 dbSNP
rs1198807142 367 dbSNP
rs570026682 377 dbSNP
rs1476692816 378 dbSNP
rs1168990406 382 dbSNP
rs760441837 384 dbSNP
rs963241373 392 dbSNP
rs1166633182 393 dbSNP
rs1489918589 395 dbSNP
rs1252950217 396 dbSNP
rs969824049 400 dbSNP
rs995534994 402 dbSNP
rs538805813 405 dbSNP
rs147792217 410 dbSNP
rs114371933 419 dbSNP
rs1249734428 425 dbSNP
rs139595957 428 dbSNP
rs545748663 429 dbSNP
rs1283681202 430 dbSNP
rs1404116380 441 dbSNP
rs1019777976 447 dbSNP
rs1330501315 447 dbSNP
rs1391422670 449 dbSNP
rs1395103288 454 dbSNP
rs1471232921 462 dbSNP
rs866392529 477 dbSNP
rs1298309594 481 dbSNP
rs1327640901 486 dbSNP
rs765496769 490 dbSNP
rs750968025 493 dbSNP
rs1365718577 505 dbSNP
rs1269505142 517 dbSNP
rs1182765813 524 dbSNP
rs574769272 528 dbSNP
rs1356869057 529 dbSNP
rs61944461 531 dbSNP
rs543823051 541 dbSNP
rs1482184306 551 dbSNP
rs945154561 557 dbSNP
rs1205725238 562 dbSNP
rs574580800 563 dbSNP
rs1462546652 572 dbSNP
rs1042576038 574 dbSNP
rs903682398 595 dbSNP
rs1001135537 599 dbSNP
rs1289253167 603 dbSNP
rs1927516 608 dbSNP
rs180759539 610 dbSNP
rs115295242 620 dbSNP
rs1454119725 622 dbSNP
rs1012892581 624 dbSNP
rs978453021 625 dbSNP
rs1448790405 632 dbSNP
rs1191743088 633 dbSNP
rs1373007241 641 dbSNP
rs1387569896 642 dbSNP
rs34238041 644 dbSNP
rs924238674 644 dbSNP
rs1159568132 651 dbSNP
rs934597822 661 dbSNP
rs1362284560 664 dbSNP
rs1057069344 670 dbSNP
rs186486499 674 dbSNP
rs895675795 675 dbSNP
rs1202921373 680 dbSNP
rs1440677370 681 dbSNP
rs971847302 685 dbSNP
rs191824755 688 dbSNP
rs1205564355 694 dbSNP
rs1004295226 698 dbSNP
rs1016125105 700 dbSNP
rs948569421 701 dbSNP
rs1044595712 702 dbSNP
rs905295869 704 dbSNP
rs12866607 708 dbSNP
rs995958904 709 dbSNP
rs1026952592 715 dbSNP
rs1446446785 723 dbSNP
rs1319314841 728 dbSNP
rs17084496 728 dbSNP
rs754480536 745 dbSNP
rs1019808919 748 dbSNP
rs1386569656 759 dbSNP
rs1165739690 761 dbSNP
rs780956667 769 dbSNP
rs945076272 773 dbSNP
rs1380019891 776 dbSNP
rs1243775597 780 dbSNP
rs1193557884 783 dbSNP
rs1446248123 789 dbSNP
rs1283676006 799 dbSNP
rs977861024 801 dbSNP
rs527365002 806 dbSNP
rs1341006591 807 dbSNP
rs540795086 819 dbSNP
rs561057606 821 dbSNP
rs968504531 822 dbSNP
rs936465961 828 dbSNP
rs1054977914 831 dbSNP
rs1358425769 832 dbSNP
rs1338859749 836 dbSNP
rs978499637 838 dbSNP
rs1405765926 844 dbSNP
rs17548396 850 dbSNP
rs1162685879 859 dbSNP
rs1411740415 870 dbSNP
rs1421526276 879 dbSNP
rs949284809 884 dbSNP
rs368460196 893 dbSNP
rs66759477 893 dbSNP
rs1406868096 896 dbSNP
rs7995071 896 dbSNP
rs200210171 901 dbSNP
rs1201401739 907 dbSNP
rs1490392830 913 dbSNP
rs549756696 922 dbSNP
rs1267749298 931 dbSNP
rs2025413 933 dbSNP
rs1462175534 934 dbSNP
rs1185929133 939 dbSNP
rs907192125 940 dbSNP
rs1444380559 953 dbSNP
rs1224511200 959 dbSNP
rs1182161109 960 dbSNP
rs1345052313 961 dbSNP
rs992773155 962 dbSNP
rs1444690270 963 dbSNP
rs1355169190 971 dbSNP
rs532716439 977 dbSNP
rs1465038560 978 dbSNP
rs898595245 981 dbSNP
rs917185380 989 dbSNP
rs948622305 1003 dbSNP
rs1044240507 1004 dbSNP
rs1451102239 1013 dbSNP
rs898961381 1031 dbSNP
rs552345711 1038 dbSNP
rs1189068131 1044 dbSNP
rs1157505576 1046 dbSNP
rs995605203 1051 dbSNP
rs1232941277 1059 dbSNP
rs1470939402 1062 dbSNP
rs1334581911 1064 dbSNP
rs565969216 1065 dbSNP
rs1381844627 1066 dbSNP
rs931451382 1068 dbSNP
rs954257533 1081 dbSNP
rs1048463996 1095 dbSNP
rs1225674001 1096 dbSNP
rs181935465 1097 dbSNP
rs1374421080 1108 dbSNP
rs554738992 1112 dbSNP
rs879892255 1115 dbSNP
rs1004180849 1121 dbSNP
rs1040998042 1127 dbSNP
rs1337771167 1129 dbSNP
rs1397967082 1129 dbSNP
rs529748237 1135 dbSNP
rs1470285027 1138 dbSNP
rs1358336986 1143 dbSNP
rs1020320203 1165 dbSNP
rs1420498444 1167 dbSNP
rs1408267007 1173 dbSNP
rs1177403777 1181 dbSNP
rs1437300411 1186 dbSNP
rs966384090 1189 dbSNP
rs978178908 1194 dbSNP
rs1260254489 1200 dbSNP
rs1483243774 1203 dbSNP
rs901426937 1205 dbSNP
rs1254628952 1208 dbSNP
rs55752689 1214 dbSNP
rs936412178 1225 dbSNP
rs1206183088 1227 dbSNP
rs1028524829 1230 dbSNP
rs916413843 1232 dbSNP
rs1315880553 1233 dbSNP
rs1046295366 1239 dbSNP
rs949231430 1239 dbSNP
rs777464381 1244 dbSNP
rs999970233 1251 dbSNP
rs1345361315 1252 dbSNP
rs1253039536 1253 dbSNP
rs1417523018 1253 dbSNP
rs1031412616 1256 dbSNP
rs955746736 1257 dbSNP
rs992513425 1264 dbSNP
rs916863921 1272 dbSNP
rs1254702445 1274 dbSNP
rs898553312 1280 dbSNP
rs749046121 1285 dbSNP
rs1262970783 1286 dbSNP
rs980420909 1289 dbSNP
rs1361931921 1291 dbSNP
rs920481233 1295 dbSNP
rs1429439735 1298 dbSNP
rs930457063 1300 dbSNP
rs771003112 1301 dbSNP
rs112680807 1330 dbSNP
rs1462384745 1331 dbSNP
rs1008380059 1335 dbSNP
rs768255220 1342 dbSNP
rs186747835 1343 dbSNP
rs1383662315 1345 dbSNP
rs537011260 1350 dbSNP
rs1297419337 1351 dbSNP
rs908649648 1356 dbSNP
rs940067841 1363 dbSNP
rs1307839994 1364 dbSNP
rs1041031030 1367 dbSNP
rs774012279 1368 dbSNP
rs901160756 1368 dbSNP
rs1456989373 1370 dbSNP
rs557372140 1371 dbSNP
rs1299693026 1379 dbSNP
rs1173127573 1384 dbSNP
rs1050412955 1388 dbSNP
rs904718360 1391 dbSNP
rs10507370 1392 dbSNP
rs1287945875 1393 dbSNP
rs1490882676 1402 dbSNP
rs1031821489 1403 dbSNP
rs1032425499 1413 dbSNP
rs1209260112 1420 dbSNP
rs191589866 1422 dbSNP
rs1346301004 1427 dbSNP
rs1253185681 1434 dbSNP
rs955778856 1438 dbSNP
rs1318608682 1445 dbSNP
rs1225431193 1447 dbSNP
rs1013980953 1450 dbSNP
rs1024009640 1452 dbSNP
rs1281390586 1452 dbSNP
rs558762945 1454 dbSNP
rs957729165 1456 dbSNP
rs572240174 1462 dbSNP
rs990559209 1463 dbSNP
rs1387926621 1465 dbSNP
rs150996788 1466 dbSNP
rs1205788303 1473 dbSNP
rs1253490752 1475 dbSNP
rs1462939475 1477 dbSNP
rs1479850195 1482 dbSNP
rs560778082 1504 dbSNP
rs529796657 1506 dbSNP
rs951926877 1507 dbSNP
rs1269152199 1518 dbSNP
rs1431706879 1531 dbSNP
rs1490719670 1534 dbSNP
rs907758072 1536 dbSNP
rs940613997 1550 dbSNP
rs140832492 1555 dbSNP
rs919925655 1557 dbSNP
rs1257375549 1564 dbSNP
rs1427933446 1567 dbSNP
rs150156766 1571 dbSNP
rs532653850 1572 dbSNP
rs9512331 1576 dbSNP
rs1275274689 1583 dbSNP
rs1232063165 1590 dbSNP
rs1172411611 1600 dbSNP
rs566055495 1607 dbSNP
rs1446901483 1609 dbSNP
rs776959403 1610 dbSNP
rs536358233 1614 dbSNP
rs528645159 1615 dbSNP
rs1366440231 1618 dbSNP
rs1329942306 1619 dbSNP
rs374371071 1622 dbSNP
rs1172416003 1623 dbSNP
rs1477126509 1633 dbSNP
rs548268441 1633 dbSNP
rs1365777586 1640 dbSNP
rs1182565120 1644 dbSNP
rs1008366347 1650 dbSNP
rs1176679006 1655 dbSNP
rs548773152 1657 dbSNP
rs1041616354 1658 dbSNP
rs902725018 1661 dbSNP
rs568416227 1664 dbSNP
rs34158019 1670 dbSNP
rs1199665276 1671 dbSNP
rs1000181515 1672 dbSNP
rs1041509073 1676 dbSNP
rs1331028740 1693 dbSNP
rs1032627701 1695 dbSNP
rs922667020 1697 dbSNP
rs1301404835 1699 dbSNP
rs569568716 1702 dbSNP
rs537025260 1710 dbSNP
rs1333860199 1711 dbSNP
rs1413148214 1712 dbSNP
rs1215720334 1714 dbSNP
rs1011941231 1716 dbSNP
rs1419382370 1724 dbSNP
rs1378538818 1725 dbSNP
rs1298357496 1726 dbSNP
rs932636483 1731 dbSNP
rs1306190780 1738 dbSNP
rs1049715636 1739 dbSNP
rs1237997167 1740 dbSNP
rs756375477 1749 dbSNP
rs904774796 1752 dbSNP
rs1292889485 1755 dbSNP
rs1490745594 1760 dbSNP
rs1219754284 1762 dbSNP
rs182929001 1763 dbSNP
rs1485898857 1772 dbSNP
rs1053292483 1774 dbSNP
rs891954560 1775 dbSNP
rs1276827187 1785 dbSNP
rs1357615863 1787 dbSNP
rs981934630 1790 dbSNP
rs1446513160 1791 dbSNP
rs1427787700 1794 dbSNP
rs1164001529 1795 dbSNP
rs1299256926 1799 dbSNP
rs1399626915 1802 dbSNP
rs1358864445 1810 dbSNP
rs1165485364 1831 dbSNP
rs1386815411 1841 dbSNP
rs777668905 1854 dbSNP
rs1194198959 1865 dbSNP
rs1374565917 1865 dbSNP
rs1487726088 1865 dbSNP
rs749414156 1865 dbSNP
rs1014034910 1867 dbSNP
rs71188739 1870 dbSNP
rs1224025205 1871 dbSNP
rs1426832546 1876 dbSNP
rs1024470153 1877 dbSNP
rs371152678 1877 dbSNP
rs772326642 1877 dbSNP
rs745337409 1878 dbSNP
rs766459099 1878 dbSNP
rs1198361691 1879 dbSNP
rs1259293161 1879 dbSNP
rs1440001590 1879 dbSNP
rs534893085 1879 dbSNP
rs73170122 1879 dbSNP
rs370715617 1880 dbSNP
rs73494729 1881 dbSNP
rs1349430047 1882 dbSNP
rs905580462 1883 dbSNP
rs1273081289 1885 dbSNP
rs1431567393 1885 dbSNP
rs1402324999 1890 dbSNP
rs1444490555 1890 dbSNP
rs1465088445 1891 dbSNP
rs570885604 1891 dbSNP
rs55825650 1893 dbSNP
rs961944988 1893 dbSNP
rs201544588 1894 dbSNP
rs912893881 1897 dbSNP
rs971667846 1900 dbSNP
rs1178540763 1902 dbSNP
rs1243384413 1903 dbSNP
rs1288690689 1904 dbSNP
rs1265379430 1908 dbSNP
rs559012170 1911 dbSNP
rs1027299858 1919 dbSNP
rs931296596 1923 dbSNP
rs141194918 1925 dbSNP
rs1184095074 1928 dbSNP
rs1308693605 1931 dbSNP
rs1244795985 1937 dbSNP
rs983319931 1942 dbSNP
rs1442530569 1949 dbSNP
rs1374582155 1952 dbSNP
rs186760491 1957 dbSNP
rs1358173933 1959 dbSNP
rs571107652 1960 dbSNP
rs368701280 1961 dbSNP
rs944121865 1968 dbSNP
rs1438309449 1977 dbSNP
rs1401446787 1979 dbSNP
rs1041174001 1987 dbSNP
rs1182766135 1994 dbSNP
rs902671848 1996 dbSNP
rs976896710 1997 dbSNP
rs773581557 1998 dbSNP
rs1219057841 2000 dbSNP
rs1354777350 2006 dbSNP
rs1285318941 2011 dbSNP
rs1054019777 2015 dbSNP
rs894079187 2016 dbSNP
rs1011892301 2022 dbSNP
rs572312394 2024 dbSNP
rs1314804610 2025 dbSNP
rs1228856987 2028 dbSNP
rs932712939 2029 dbSNP
rs1385182359 2030 dbSNP
rs1450722804 2049 dbSNP
rs1378140796 2052 dbSNP
rs1300918931 2054 dbSNP
rs1360771559 2059 dbSNP
rs1296978057 2062 dbSNP
rs1283887234 2070 dbSNP
rs985882049 2073 dbSNP
rs1166080844 2086 dbSNP
rs145018063 2089 dbSNP
rs1412072377 2092 dbSNP
rs1282016997 2095 dbSNP
rs1488708979 2097 dbSNP
rs970465826 2109 dbSNP
rs1214488933 2122 dbSNP
rs936264962 2124 dbSNP
rs1266157639 2131 dbSNP
rs1245404555 2135 dbSNP
rs1328421255 2139 dbSNP
rs371097447 2144 dbSNP
rs1203682530 2148 dbSNP
rs1264464944 2163 dbSNP
rs1340692127 2165 dbSNP
rs144899773 2165 dbSNP
rs374898210 2165 dbSNP
rs1397806053 2186 dbSNP
rs1392244013 2189 dbSNP
rs367931314 2200 dbSNP
rs973234573 2207 dbSNP
rs1348664245 2212 dbSNP
rs1173215225 2213 dbSNP
rs1478372721 2214 dbSNP
rs1027505693 2218 dbSNP
rs1470697607 2219 dbSNP
rs953303820 2231 dbSNP
rs534925509 2232 dbSNP
rs771036312 2234 dbSNP
rs1406357655 2241 dbSNP
rs554793612 2252 dbSNP
rs950253582 2253 dbSNP
rs1045861579 2265 dbSNP
rs1271219762 2283 dbSNP
rs905630207 2295 dbSNP
rs1318311154 2329 dbSNP
rs1257253456 2331 dbSNP
rs924070595 2333 dbSNP
rs1332468025 2341 dbSNP
rs1301294164 2351 dbSNP
rs1468346920 2352 dbSNP
rs574441346 2358 dbSNP
rs1333720803 2364 dbSNP
rs1355372013 2370 dbSNP
rs1366065681 2372 dbSNP
rs935472265 2374 dbSNP
rs1053973690 2380 dbSNP
rs1277569107 2391 dbSNP
rs1169066550 2394 dbSNP
rs1467714897 2397 dbSNP
rs1349723807 2398 dbSNP
rs1001264142 2417 dbSNP
rs1378438509 2423 dbSNP
rs1198188965 2425 dbSNP
rs1431540460 2429 dbSNP
rs9581713 2431 dbSNP
rs35705788 2434 dbSNP
rs948288742 2437 dbSNP
rs1285176794 2439 dbSNP
rs1257118202 2450 dbSNP
rs1193875209 2456 dbSNP
rs1320768334 2457 dbSNP
rs1045382764 2461 dbSNP
rs887427593 2463 dbSNP
rs1232133866 2469 dbSNP
rs1345087446 2475 dbSNP
rs1310886194 2483 dbSNP
rs562925122 2486 dbSNP
rs1448158319 2487 dbSNP
rs1218170697 2488 dbSNP
rs1376811300 2488 dbSNP
rs1327201506 2489 dbSNP
rs1004796764 2490 dbSNP
rs1014786729 2502 dbSNP
rs1464785586 2503 dbSNP
rs965901200 2512 dbSNP
rs766938581 2513 dbSNP
rs1382244083 2515 dbSNP
rs1159331663 2520 dbSNP
rs56334342 2523 dbSNP
rs1440174453 2524 dbSNP
rs1237519859 2525 dbSNP
rs1179351342 2535 dbSNP
rs1443901008 2536 dbSNP
rs576404374 2537 dbSNP
rs1003240310 2539 dbSNP
rs1199511691 2540 dbSNP
rs545411753 2542 dbSNP
rs1015070413 2545 dbSNP
rs1240256176 2554 dbSNP
rs559580063 2555 dbSNP
rs1247674816 2559 dbSNP
rs1027446939 2560 dbSNP
rs953251731 2566 dbSNP
rs1200758985 2568 dbSNP
rs1362707935 2573 dbSNP
rs752049044 2577 dbSNP
rs1419212489 2590 dbSNP
rs985547828 2591 dbSNP
rs1018891002 2592 dbSNP
rs925965351 2596 dbSNP
rs935982258 2597 dbSNP
rs1172091658 2603 dbSNP
rs1484450427 2604 dbSNP
rs759139363 2605 dbSNP
rs1420423163 2607 dbSNP
rs1216652435 2609 dbSNP
rs1487656754 2613 dbSNP
rs1281581924 2635 dbSNP
rs1411871701 2636 dbSNP
rs779366491 2642 dbSNP
rs766909584 2644 dbSNP
rs112074642 2645 dbSNP
rs1279046364 2646 dbSNP
rs1399683903 2648 dbSNP
rs1343498019 2649 dbSNP
rs1325686297 2650 dbSNP
rs913492008 2658 dbSNP
rs950308451 2660 dbSNP
rs1163879349 2661 dbSNP
rs1474121098 2665 dbSNP
rs1425556198 2673 dbSNP
rs548487707 2677 dbSNP
rs1343595605 2685 dbSNP
rs553879610 2686 dbSNP
rs1046335682 2700 dbSNP
rs1477330532 2701 dbSNP
rs1239797277 2702 dbSNP
rs989611057 2706 dbSNP
rs927472299 2716 dbSNP
rs553145899 2735 dbSNP
rs937111730 2739 dbSNP
rs1289835624 2742 dbSNP
rs1048795723 2745 dbSNP
rs915411480 2750 dbSNP
rs1259177686 2755 dbSNP
rs562340379 2763 dbSNP
rs1231823673 2768 dbSNP
rs887478662 2773 dbSNP
rs948238231 2777 dbSNP
rs1340952837 2780 dbSNP
rs1331570014 2781 dbSNP
rs1045328507 2783 dbSNP
rs1212431040 2789 dbSNP
rs574644095 2799 dbSNP
rs1171131349 2806 dbSNP
rs1004512418 2812 dbSNP
rs1408953249 2820 dbSNP
rs906809484 2821 dbSNP
rs1223732836 2826 dbSNP
rs938992355 2843 dbSNP
rs1478054173 2844 dbSNP
rs1245678256 2846 dbSNP
rs574072886 2852 dbSNP
rs755747604 2860 dbSNP
rs1459532091 2871 dbSNP
rs901786047 2880 dbSNP
rs1239096877 2882 dbSNP
rs1450409258 2884 dbSNP
rs1198422524 2888 dbSNP
rs1198171080 2891 dbSNP
rs1281032124 2893 dbSNP
rs997413000 2902 dbSNP
rs138859971 2924 dbSNP
rs1301412376 2925 dbSNP
rs1438541618 2939 dbSNP
rs1379043466 2947 dbSNP
rs1331735172 2949 dbSNP
rs1441249731 2950 dbSNP
rs1352590535 2957 dbSNP
rs1177767127 2959 dbSNP
rs1048830179 2964 dbSNP
rs10159 2968 dbSNP
rs1393956351 2972 dbSNP
rs1171200593 2986 dbSNP
rs1007370115 2990 dbSNP
rs1381496658 2990 dbSNP
rs570971360 2991 dbSNP
rs1165260997 2999 dbSNP
rs1363572496 3003 dbSNP
rs557392882 3007 dbSNP
rs189809099 3013 dbSNP
rs1211070538 3015 dbSNP
rs1327661764 3017 dbSNP
rs1442126652 3017 dbSNP
rs988831359 3019 dbSNP
rs998561702 3023 dbSNP
rs1355718947 3028 dbSNP
rs143711243 3035 dbSNP
rs956732386 3043 dbSNP
rs565830731 3055 dbSNP
rs1370895279 3059 dbSNP
rs972087765 3071 dbSNP
rs534960370 3072 dbSNP
rs752981672 3072 dbSNP
rs981700699 3075 dbSNP
rs867544440 3079 dbSNP
rs1374484113 3086 dbSNP
rs1383103918 3087 dbSNP
rs115583409 3094 dbSNP
rs937517757 3101 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
Conditions HEK293
Disease 10810.0
Location of target site 3'UTR
Tools used in this research TargetScan , miRTarCLIP , Piranha
Original Description (Extracted from the article) ... "PAR-CLIP data was present in GSM1065667. RNA binding protein: AGO1. Condition:4-thiouridine ...

- Memczak S; Jens M; Elefsinioti A; Torti F; et al., 2013, Nature.

miRNA-target interactions (Provided by authors)
ID Duplex structure Position
1 
miRNA  3' ugugugguuccuAUUAAAGAGg 5'
                      ||||||||| 
Target 5' -----------cUAAUUUCUCu 3'
 		1 - 11
Article - Memczak S; Jens M; Elefsinioti A; Torti F; et al.
- Nature, 2013
Circular RNAs (circRNAs) in animals are an enigmatic class of RNA with unknown function. To explore circRNAs systematically, we sequenced and computationally analysed human, mouse and nematode RNA. We detected thousands of well-expressed, stable circRNAs, often showing tissue/developmental-stage-specific expression. Sequence analysis indicated important regulatory functions for circRNAs. We found that a human circRNA, antisense to the cerebellar degeneration-related protein 1 transcript (CDR1as), is densely bound by microRNA (miRNA) effector complexes and harbours 63 conserved binding sites for the ancient miRNA miR-7. Further analyses indicated that CDR1as functions to bind miR-7 in neuronal tissues. Human CDR1as expression in zebrafish impaired midbrain development, similar to knocking down miR-7, suggesting that CDR1as is a miRNA antagonist with a miRNA-binding capacity ten times higher than any other known transcript. Together, our data provide evidence that circRNAs form a large class of post-transcriptional regulators. Numerous circRNAs form by head-to-tail splicing of exons, suggesting previously unrecognized regulatory potential of coding sequences.
LinkOut: [PMID: 23446348]
Experimental Support 2 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
CLIP-seq Support 1 for dataset GSM1065667
Method / RBP PAR-CLIP / AGO1
Cell line / Condition HEK293 / 4-thiouridine, ML_MM_6
Location of target site ENST00000335327.5 | 3UTR | CUAAUUUCUCUCUCUCUCUCUUU
Tools used in this analysis TargetScan, miRTarCLIP, and Piranha
Article / Accession Series PMID: 23446348 / GSE43573
CLIP-seq Viewer Link
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer -0.668 1.8e-4 -0.641 3.7e-4 24 Click to see details
GSE26953 Aortic valvular endothelial cells -0.571 1.8e-3 -0.695 8.2e-5 24 Click to see details
GSE28260 Renal cortex and medulla 0.731 2.3e-3 0.478 4.9e-2 13 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.469 9.0e-3 0.590 9.5e-4 25 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.409 2.1e-2 0.330 5.4e-2 25 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.691 6.4e-2 0.714 5.5e-2 6 Click to see details
GSE19536 Breast cancer 0.115 1.3e-1 0.134 9.2e-2 100 Click to see details
GSE19783 ER- ER- breast cancer 0.104 1.8e-1 0.105 1.8e-1 79 Click to see details
GSE14794 Lymphoblastoid cells 0.092 1.9e-1 0.220 1.9e-2 90 Click to see details
GSE17498 Multiple myeloma 0.136 2.0e-1 0.214 9.2e-2 40 Click to see details
GSE32688 Pancreatic cancer 0.146 2.1e-1 -0.028 4.4e-1 32 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.187 2.1e-1 -0.423 3.2e-2 20 Click to see details
GSE21687 Ependynoma primary tumors 0.091 2.4e-1 -0.084 2.5e-1 64 Click to see details
GSE27834 Pluripotent stem cells -0.152 2.9e-1 -0.085 3.8e-1 16 Click to see details
GSE38226 Liver fibrosis -0.114 3.1e-1 -0.036 4.4e-1 21 Click to see details
GSE19350 CNS germ cell tumors -0.153 3.2e-1 -0.119 3.6e-1 12 Click to see details
GSE17306 Multiple myeloma 0.067 3.2e-1 0.104 2.4e-1 49 Click to see details
GSE21032 Prostate cancer -0.032 3.9e-1 -0.024 4.1e-1 83 Click to see details
GSE42095 Differentiated embryonic stem cells 0.062 3.9e-1 -0.036 4.4e-1 23 Click to see details
GSE19783 ER+ ER+ breast cancer 0.04 4.3e-1 0.098 3.4e-1 20 Click to see details
GSE19783 ER+ ER+ breast cancer 0.04 4.3e-1 0.098 3.4e-1 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
HNSC 0.317 0.02 0.257 0.05 42 Click to see details
PRAD -0.264 0.04 -0.216 0.07 47 Click to see details
KIRC -0.21 0.05 -0.134 0.14 66 Click to see details
LUAD -0.593 0.08 -0.607 0.07 7 Click to see details
STAD -0.252 0.09 -0.325 0.04 31 Click to see details
COAD -0.499 0.1 -0.476 0.12 8 Click to see details
BRCA -0.117 0.14 -0.130 0.12 84 Click to see details
BLCA -0.264 0.14 0.022 0.47 18 Click to see details
LIHC -0.145 0.16 -0.099 0.25 48 Click to see details
PAAD 0.628 0.19 0.600 0.2 4 Click to see details
PCPG -0.789 0.21 -1.000 0.5 3 Click to see details
ESCA 0.249 0.23 -0.027 0.47 11 Click to see details
CHOL -0.279 0.23 -0.083 0.42 9 Click to see details
KIRP -0.136 0.24 -0.105 0.29 30 Click to see details
CESC -0.674 0.26 -0.500 0.33 3 Click to see details
THCA -0.085 0.28 -0.101 0.24 50 Click to see details
KICH -0.118 0.3 -0.095 0.33 23 Click to see details
LUSC 0.054 0.38 -0.037 0.41 37 Click to see details
UCEC -0.004 0.49 -0.054 0.41 19 Click to see details
UCEC -0.004 0.49 -0.054 0.41 19 Click to see details
UCEC -0.004 0.49 -0.054 0.41 19 Click to see details
193 hsa-miR-539-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT053510 TWIST1 twist family bHLH transcription factor 1 4 1
MIRT053516 ZEB1 zinc finger E-box binding homeobox 1 4 1
MIRT057687 LCOR ligand dependent nuclear receptor corepressor 2 8
MIRT066722 CCT2 chaperonin containing TCP1 subunit 2 2 6
MIRT071515 CALM1 calmodulin 1 1 1
MIRT084964 BACH1 BTB domain and CNC homolog 1 2 2
MIRT096759 GPBP1 GC-rich promoter binding protein 1 2 2
MIRT099799 SOX4 SRY-box 4 2 2
MIRT126502 OTUD1 OTU deubiquitinase 1 2 2
MIRT163869 WDR1 WD repeat domain 1 2 2
MIRT176316 DDX3Y DEAD-box helicase 3, Y-linked 2 2
MIRT182188 POU2F1 POU class 2 homeobox 1 2 4
MIRT234348 MSL1 male specific lethal 1 homolog 2 8
MIRT244630 YTHDF3 YTH N6-methyladenosine RNA binding protein 3 2 4
MIRT262597 ZNF37A zinc finger protein 37A 2 2
MIRT282630 IGF1R insulin like growth factor 1 receptor 2 2
MIRT287286 PSME3 proteasome activator subunit 3 2 2
MIRT310569 DCK deoxycytidine kinase 2 4
MIRT335358 PEBP1 phosphatidylethanolamine binding protein 1 1 1
MIRT367797 PRRG4 proline rich and Gla domain 4 2 2
MIRT439294 WASF3 WAS protein family member 3 2 3
MIRT439373 TULP3 tubby like protein 3 1 1
MIRT439515 STT3A STT3A, catalytic subunit of the oligosaccharyltransferase complex 1 1
MIRT439603 SLC39A6 solute carrier family 39 member 6 1 1
MIRT439659 SFMBT2 Scm like with four mbt domains 2 1 1
MIRT439661 SF3B1 splicing factor 3b subunit 1 1 1
MIRT439664 SETX senataxin 1 1
MIRT439728 RPS4X ribosomal protein S4, X-linked 1 1
MIRT440082 NUCB2 nucleobindin 2 1 1
MIRT440321 LOC728392 uncharacterized LOC728392 1 1
MIRT440354 KLHL2 kelch like family member 2 1 1
MIRT440371 KIF21A kinesin family member 21A 1 1
MIRT440412 KAT2B lysine acetyltransferase 2B 1 1
MIRT440606 FXR2 FMR1 autosomal homolog 2 1 1
MIRT440789 DNMT3A DNA methyltransferase 3 alpha 1 1
MIRT440803 DNAJB9 DnaJ heat shock protein family (Hsp40) member B9 1 1
MIRT440919 CNOT4 CCR4-NOT transcription complex subunit 4 1 1
MIRT440975 CDC27 cell division cycle 27 1 1
MIRT441206 ARFGEF2 ADP ribosylation factor guanine nucleotide exchange factor 2 1 1
MIRT441291 ACPP acid phosphatase, prostate 1 1
MIRT441634 KDM5A lysine demethylase 5A 2 2
MIRT442560 CAB39 calcium binding protein 39 2 2
MIRT443087 PTPRN2 protein tyrosine phosphatase, receptor type N2 2 2
MIRT443454 CLIC5 chloride intracellular channel 5 2 2
MIRT443721 TAF1B TATA-box binding protein associated factor, RNA polymerase I subunit B 2 2
MIRT443772 STS steroid sulfatase 2 2
MIRT444081 C12orf73 chromosome 12 open reading frame 73 2 2
MIRT444548 UBE2D3 ubiquitin conjugating enzyme E2 D3 2 2
MIRT444564 TRA2B transformer 2 beta homolog 2 2
MIRT444723 LAMA2 laminin subunit alpha 2 2 2
MIRT444958 ADAM22 ADAM metallopeptidase domain 22 2 2
MIRT445051 SLC16A9 solute carrier family 16 member 9 2 2
MIRT445143 IKBIP IKBKB interacting protein 2 2
MIRT445415 ACSL6 acyl-CoA synthetase long chain family member 6 2 2
MIRT445620 CLIC4 chloride intracellular channel 4 2 2
MIRT445967 IKZF5 IKAROS family zinc finger 5 2 2
MIRT446159 RPL12 ribosomal protein L12 2 2
MIRT446231 C17orf80 chromosome 17 open reading frame 80 2 2
MIRT446392 HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 2 2
MIRT446944 ZMAT3 zinc finger matrin-type 3 2 2
MIRT447194 CDCP1 CUB domain containing protein 1 2 2
MIRT447360 FAM161B family with sequence similarity 161 member B 2 2
MIRT447793 RCBTB1 RCC1 and BTB domain containing protein 1 2 2
MIRT447830 CTIF cap binding complex dependent translation initiation factor 2 2
MIRT448123 CCDC80 coiled-coil domain containing 80 2 2
MIRT448401 TNRC6C trinucleotide repeat containing 6C 2 2
MIRT448720 ITGA2 integrin subunit alpha 2 2 2
MIRT448800 GLIS3 GLIS family zinc finger 3 2 2
MIRT449070 CNDP2 carnosine dipeptidase 2 2 2
MIRT449122 XRRA1 X-ray radiation resistance associated 1 2 2
MIRT449412 TRIM5 tripartite motif containing 5 2 2
MIRT449712 TSPYL1 TSPY like 1 2 2
MIRT449845 BCL2L13 BCL2 like 13 2 2
MIRT449944 IGF1 insulin like growth factor 1 2 2
MIRT450088 OR2A4 olfactory receptor family 2 subfamily A member 4 2 2
MIRT450808 NUFIP2 NUFIP2, FMR1 interacting protein 2 2 6
MIRT451876 SOD2 superoxide dismutase 2 2 8
MIRT452003 FKBP5 FK506 binding protein 5 2 2
MIRT452244 TRAM1 translocation associated membrane protein 1 2 2
MIRT453892 DUSP18 dual specificity phosphatase 18 2 2
MIRT457507 SLC35F6 solute carrier family 35 member F6 2 2
MIRT458522 C5orf22 chromosome 5 open reading frame 22 2 2
MIRT459799 POTED POTE ankyrin domain family member D 2 10
MIRT459869 KIAA1191 KIAA1191 2 2
MIRT460004 DNALI1 dynein axonemal light intermediate chain 1 2 2
MIRT464765 UBE2G1 ubiquitin conjugating enzyme E2 G1 2 2
MIRT464933 TXLNA taxilin alpha 2 2
MIRT465140 TSC22D2 TSC22 domain family member 2 2 2
MIRT469364 REST RE1 silencing transcription factor 2 6
MIRT474820 KIAA0226 RUN and cysteine rich domain containing beclin 1 interacting protein 2 2
MIRT475668 HIATL1 major facilitator superfamily domain containing 14B 2 4
MIRT476144 GPR137C G protein-coupled receptor 137C 2 8
MIRT478054 DNAJC10 DnaJ heat shock protein family (Hsp40) member C10 2 8
MIRT478588 CTDSPL2 CTD small phosphatase like 2 2 2
MIRT478805 CRTAP cartilage associated protein 2 2
MIRT479295 CHAC1 ChaC glutathione specific gamma-glutamylcyclotransferase 1 2 2
MIRT481480 ARL8B ADP ribosylation factor like GTPase 8B 2 2
MIRT484232 IER2 immediate early response 2 2 2
MIRT485424 LDLR low density lipoprotein receptor 2 6
MIRT486920 CSTF2 cleavage stimulation factor subunit 2 2 4
MIRT488396 PDE4DIP phosphodiesterase 4D interacting protein 2 2
MIRT488426 COPA coatomer protein complex subunit alpha 2 2
MIRT489553 SOX11 SRY-box 11 2 6
MIRT493068 MTCH1 mitochondrial carrier 1 2 2
MIRT494096 DPY19L1 dpy-19 like C-mannosyltransferase 1 2 2
MIRT497894 STRN striatin 2 2
MIRT498084 SETD5 SET domain containing 5 2 2
MIRT499923 GPX8 glutathione peroxidase 8 (putative) 2 2
MIRT501618 PISD phosphatidylserine decarboxylase 2 2
MIRT501835 NCOA2 nuclear receptor coactivator 2 2 2
MIRT502043 LAMTOR1 late endosomal/lysosomal adaptor, MAPK and MTOR activator 1 2 6
MIRT502255 HNRNPF heterogeneous nuclear ribonucleoprotein F 2 2
MIRT502327 GIGYF1 GRB10 interacting GYF protein 1 2 2
MIRT502991 CCDC71L coiled-coil domain containing 71 like 2 8
MIRT505415 TCF7L2 transcription factor 7 like 2 2 4
MIRT505694 SESN3 sestrin 3 2 2
MIRT506325 ONECUT2 one cut homeobox 2 2 2
MIRT506331 NUPL2 nucleoporin like 2 2 4
MIRT506877 KIAA0101 PCNA clamp associated factor 2 6
MIRT508237 ZNF121 zinc finger protein 121 2 4
MIRT509849 MSANTD4 Myb/SANT DNA binding domain containing 4 with coiled-coils 2 6
MIRT510002 UCP1 uncoupling protein 1 2 6
MIRT510324 SLC2A3 solute carrier family 2 member 3 2 4
MIRT511449 HNRNPU heterogeneous nuclear ribonucleoprotein U 2 6
MIRT512379 PHB2 prohibitin 2 2 2
MIRT513672 SMG1 SMG1, nonsense mediated mRNA decay associated PI3K related kinase 2 4
MIRT516479 RAB32 RAB32, member RAS oncogene family 2 4
MIRT517589 ZNF579 zinc finger protein 579 2 4
MIRT520501 TRAM2 translocation associated membrane protein 2 2 6
MIRT521656 PRKD3 protein kinase D3 2 2
MIRT524646 C4orf32 family with sequence similarity 241 member A 2 2
MIRT528365 ZMYM1 zinc finger MYM-type containing 1 2 4
MIRT530455 SULT1B1 sulfotransferase family 1B member 1 2 2
MIRT537168 GGA2 golgi associated, gamma adaptin ear containing, ARF binding protein 2 2 2
MIRT537761 ELAVL2 ELAV like RNA binding protein 2 2 2
MIRT537959 DPYSL2 dihydropyrimidinase like 2 2 2
MIRT539317 AHSA2 activator of HSP90 ATPase homolog 2 2 2
MIRT539610 SHISA9 shisa family member 9 2 2
MIRT539641 BUB1 BUB1 mitotic checkpoint serine/threonine kinase 2 2
MIRT540335 OPHN1 oligophrenin 1 2 2
MIRT543806 COCH cochlin 2 2
MIRT544135 GLO1 glyoxalase I 2 4
MIRT544497 SLC25A46 solute carrier family 25 member 46 2 2
MIRT544792 ZKSCAN8 zinc finger with KRAB and SCAN domains 8 2 2
MIRT545832 ZNF367 zinc finger protein 367 2 4
MIRT546461 SLC39A14 solute carrier family 39 member 14 2 2
MIRT546578 SAR1A secretion associated Ras related GTPase 1A 2 2
MIRT548379 ENPP5 ectonucleotide pyrophosphatase/phosphodiesterase 5 (putative) 2 4
MIRT549858 MCM4 minichromosome maintenance complex component 4 2 2
MIRT550705 TP53RK TP53 regulating kinase 2 4
MIRT550839 ABRACL ABRA C-terminal like 2 2
MIRT551955 RNF157 ring finger protein 157 2 2
MIRT552508 ZIK1 zinc finger protein interacting with K protein 1 2 4
MIRT553922 STK11IP serine/threonine kinase 11 interacting protein 2 2
MIRT555151 PTPDC1 protein tyrosine phosphatase domain containing 1 2 2
MIRT555348 PPP1R37 protein phosphatase 1 regulatory subunit 37 2 2
MIRT559946 TRMT112 tRNA methyltransferase subunit 11-2 2 2
MIRT560145 RNPS1 RNA binding protein with serine rich domain 1 2 2
MIRT560848 OSBPL3 oxysterol binding protein like 3 2 2
MIRT561238 ZNF652 zinc finger protein 652 2 2
MIRT562248 GRWD1 glutamate rich WD repeat containing 1 2 2
MIRT563485 ZWINT ZW10 interacting kinetochore protein 2 2
MIRT563872 BASP1 brain abundant membrane attached signal protein 1 2 2
MIRT568196 CBX6 chromobox 6 2 2
MIRT571648 SF1 splicing factor 1 2 2
MIRT574107 SPINT2 serine peptidase inhibitor, Kunitz type 2 2 2
MIRT608237 PARP15 poly(ADP-ribose) polymerase family member 15 2 2
MIRT609337 HRASLS5 HRAS like suppressor family member 5 2 2
MIRT612010 COX17 COX17, cytochrome c oxidase copper chaperone 2 2
MIRT612278 ZNF226 zinc finger protein 226 2 2
MIRT612726 NFAM1 NFAT activating protein with ITAM motif 1 2 4
MIRT623647 HS3ST5 heparan sulfate-glucosamine 3-sulfotransferase 5 2 2
MIRT644590 SPOP speckle type BTB/POZ protein 2 2
MIRT647567 ZNF660 zinc finger protein 660 2 2
MIRT649818 PSMC1 proteasome 26S subunit, ATPase 1 2 2
MIRT650882 PPP1R15A protein phosphatase 1 regulatory subunit 15A 2 2
MIRT654470 RANBP2 RAN binding protein 2 2 2
MIRT662531 PTCD2 pentatricopeptide repeat domain 2 2 2
MIRT667796 JHDM1D lysine demethylase 7A 1 1
MIRT668978 CLCN3 chloride voltage-gated channel 3 2 2
MIRT696546 HIST1H3B histone cluster 1 H3 family member b 2 2
MIRT697819 UBQLN1 ubiquilin 1 2 2
MIRT704048 EDEM3 ER degradation enhancing alpha-mannosidase like protein 3 2 2
MIRT705514 ARL6IP1 ADP ribosylation factor like GTPase 6 interacting protein 1 2 2
MIRT715899 SIPA1L1 signal induced proliferation associated 1 like 1 2 2
MIRT716350 C10orf105 chromosome 10 open reading frame 105 2 2
MIRT716638 DPY19L4 dpy-19 like 4 2 2
MIRT721205 PUS7L pseudouridylate synthase 7 like 2 2
MIRT732106 CDK4 cyclin dependent kinase 4 3 1
MIRT732127 CARD11 caspase recruitment domain family member 11 3 1
MIRT736678 TRIAP1 TP53 regulated inhibitor of apoptosis 1 3 0
MIRT755656 SLC11A2 solute carrier family 11 member 2 3 1
MIRT755660 Irak3 interleukin-1 receptor-associated kinase 3 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-539 Budesonide approved 5281004 Microarray neonatal mice liver 20145010 2010 up-regulated
miR-539 17beta-estradiol (E2) approved 5757 Microarray rat breast 17700064 2007 down-regulated
miR-539 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-539 Longevinex NULL NULL Quantitative real-time PCR ischemia/reperfusion [I/R] rat model 21203465 2011 up-regulated
miR-539 Resveratrol NULL 445154 Quantitative real-time PCR ischemia/reperfusion [I/R] rat model 21203465 2011 down-regulated
miR-539-5p Atorvastatin approved 60823 Microarray PC3 prostate cancer cells 23936432 2013 down-regualted
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-539 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-539 Fluorouracil 3385 NSC19893 approved resistant cell line (OE19)
hsa-mir-539 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-539-5p (1-(((2-amino-6-chloro-4-pyrimidinyl)amino)methyl)-3-isopropylcyclobutyl)methanol 385230 NSC676343 sensitive
hsa-miR-539-5p (2S,6S,7S,12R)-16-bromo-9-tert-butyl-4-phenyl-4,20-diazapentacyclo[11.7.0.02,6.07,12.014,19]icosa-1(13),14(19),15,17-tetraene-3,5-dione 372657 NSC648154 sensitive
hsa-miR-539-5p (2Z)-2-(tert-butylhydrazinylidene)-N-(3-chloro-1,4-dioxonaphthalen-2-yl)-3-(3,7,12-trioxo-4H-naphtho[2,3-h]quinoxalin-2-yl)propanamide 5479912 NSC649574 resistant
hsa-miR-539-5p (4S,5R)-4-(2-methylpropyl)-3-[(1R)-1-phenylethyl]-5-phenylmethoxyoxathiazinane 2,2-dioxide 390837 NSC688895 sensitive
hsa-miR-539-5p (5z)-3-[4-benzoyl-2-[(4z)-5-oxo-2-phenyl-4-[(3,4,5-trimethoxyphenyl)methylidene]imidazol-1-yl]phenyl]-2-phenyl-5-[(3,4,5-trimethoxyphenyl)methylidene]imidazol-4-one NSC711885 sensitive
hsa-miR-539-5p (8S,9S,10R,11S,13S,14S,17S)-11-hydroxy-10,13-dimethyl-17-(2-phenyl-1,3-thiazol-4-yl)-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one 261360 NSC93354 sensitive
hsa-miR-539-5p (E)-1-[4-(quinazolin-4-ylamino)phenyl]-3-(2,4,6-trimethoxyphenyl)prop-2-en-1-one 155816064 NSC760015 sensitive
hsa-miR-539-5p (E)-N-ethyl-3-(4-methoxyphenyl)-2-(3,4,5-trimethoxyphenyl)prop-2-enamide 5388754 NSC638409 sensitive
hsa-miR-539-5p (Z)-3-[5-[3,5-bis(trifluoromethyl)phenyl]furan-2-yl]prop-2-enenitrile 5468615 NSC672868 sensitive
hsa-miR-539-5p [(1s,2s,3r,4s,7r,9s,10s,12r,15s)-4,12-diacetyloxy-15-[(2r,3s)-3-benzamido-2-hydroxy-3-(2-methylphenyl)propanoyl]oxy-1,9-dihydroxy-10,14,17,17-tetramethyl-11-oxo-6-oxatetracyclo[11.3.1.03,10.04,7]hepta 383478 NSC671870 sensitive
hsa-miR-539-5p [(3bR,9aS,11aS)-2-(2-hydroxy-5-oxo-2H-furan-3-yl)-3b,6,6,9a-tetramethyl-2,3,3a,4,5,5a,7,8,9,9b,10,11-dodecahydronaphtho[2,1-e][1]benzofuran-11a-yl]methyl acetate 378635 NSC661428 sensitive
hsa-miR-539-5p [(8R,10S,13R)-7,12-diacetyloxy-17-[5,5-bis(4-chlorophenyl)pent-4-en-2-yl]-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-yl] acetate 376380 NSC657282 sensitive
hsa-miR-539-5p [acetyl-[5-(trityloxymethyl)spiro[3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxole-2,1'-cyclopentane]-6-yl]amino] acetate 374290 NSC651809 sensitive
hsa-miR-539-5p {2-[(benzylamino)methyl]-1h-indole-1,3-diyl}bis(phenylmethanone) 374841 NSC653267 sensitive
hsa-miR-539-5p 1-(9-methoxy-11,12-dihydro-6h-indolo[1,2-b][2]benzazepin-13-yl)ethanone 365697 NSC633551 sensitive
hsa-miR-539-5p 1-(acetyloxy)-2-(2-(1-(acetyloxy)-1h-benzimidazol-2-yl)phenyl)-1h-benzimidazole 355531 NSC609356 sensitive
hsa-miR-539-5p 1-(benzenesulfonyl)-2-[1-(benzenesulfonyl)-3-methylindol-2-yl]-3-methylindole 396901 NSC704080 resistant
hsa-miR-539-5p 1-[10-[4-(dimethylamino)-2-methylquinolin-1-ium-1-yl]decyl]-N,N,2-trimethylquinolin-1-ium-4-amine;perchlorate 387883 NSC682095 sensitive
hsa-miR-539-5p 1-[2-(3-chloropropyl)phenyl]-3,4-dihydroisoquinoline;hydrochloride 390024 NSC686940 sensitive
hsa-miR-539-5p 1-[3-(3,4-dimethoxyphenyl)-2-(2,4-dinitrophenyl)-3,4-dihydropyrazol-5-yl]naphthalen-2-ol 390439 NSC687793 sensitive
hsa-miR-539-5p 1-[5-[[[4-chlorobutyl(methyl)amino]-[(5-nitrofuran-2-yl)methoxy]phosphoryl]oxymethyl]-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione 404846 NSC721390 sensitive
hsa-miR-539-5p 1-benzyl-2-methyl-1-(2-phenylethyl)-4,5-dihydroimidazol-1-ium 413544 NSC49460 sensitive
hsa-miR-539-5p 1-benzyl-3-hexadecyl-2-methylimidazolium chloride 44219704 NSC745343 sensitive
hsa-miR-539-5p 10-methyl-2-[(3,4,5-trimethoxyphenyl)methyl]phenothiazine-1-carbonitrile 374832 NSC653255 sensitive
hsa-miR-539-5p 13-methoxy-6-methyl-2-nitro-6,9,17-triazatetracyclo[8.7.1.05,18.011,16]octadeca-1,3,5(18),10,12,14,16-heptaene 438699 NSC658995 resistant
hsa-miR-539-5p 2-(2-naphthyl)-5,7-dimethyl-1,8-naphthyridin-4(1h)-one 5468909 NSC679021 sensitive
hsa-miR-539-5p 2-(4-chlorophenyl)-1-methylene-3-phenyl-pyrazino[1,2-a]benzimidazole 390230 NSC687522 resistant
hsa-miR-539-5p 2-(6-benzoyl-1h-benzimidazol-2-yl)-3,4,5,6-tetrachloro-n-(furan-2-yl)benzamide 402231 NSC716122 sensitive
hsa-miR-539-5p 2-(hydroxymethyl)-5-[6-(2-propan-2-ylidenehydrazinyl)purin-9-yl]oxolane-3,4-diol 60147745 NSC752330 resistant
hsa-miR-539-5p 2-(trifluoromethyl)benzimidazo[2,1-b][1,3,5]benzothiadiazepin-12(13h)-imine 383194 NSC671313 sensitive
hsa-miR-539-5p 2-[[6-[[bis(carboxymethyl)amino]methyl]-4-[2-[4-(2-phenylethynyl)phenyl]ethynyl]pyridin-2-yl]methyl-(carboxymethyl)amino]acetic acid 369524 NSC641379 resistant
hsa-miR-539-5p 2-[2-[5-(ethoxycarbonylcarbamoyl)-3-methyl-2,4-dioxopyrimidin-1-yl]ethylsulfanyl]ethyl n-[6-[2-[2-[5-(ethoxycarbonylcarbamoyl)-3-methyl-2,4-dioxopyrimidin-1-yl]ethylsulfanyl]ethoxycarbonylamino]hexyl] 367630 NSC637505 sensitive
hsa-miR-539-5p 2-[2-methoxy-5-[(E)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenoxy]acetic acid 5934333 NSC643813 sensitive
hsa-miR-539-5p 2-acetyl-1,2-dihydroellipticine 376328 NSC657149 resistant
hsa-miR-539-5p 2-azaadenine 5480214 NSC57048 resistant
hsa-miR-539-5p 2-ethyl-n-phenyl-5,6,7,8-tetrahydrothieno[2,3-b]quinolin-4-amine 365483 NSC633116 sensitive
hsa-miR-539-5p 2-methyl-1-[10-[(2-methylquinolin-4-yl)amino]decyl]quinolin-1-ium-4-amine;chloride;hydrochloride 387885 NSC682096 sensitive
hsa-miR-539-5p 2-methyl-4,4-diphenyl-1,4-benzoxaphosphinin-4-ium;bromide 24199840 NSC346098 sensitive
hsa-miR-539-5p 2-n-[3-(diethylaminomethyl)-4-methoxyphenyl]-4-n-[4-(dimethylamino)cyclohexyl]quinazoline-2,4-diamine;hydrochloride 54610390 NSC174030 sensitive
hsa-miR-539-5p 2,2'-spirobi[indane]-5,5'-dicarbaldehyde 382743 NSC670421 sensitive
hsa-miR-539-5p 2,2'(1h,1'h)-spirobi[s-indacen]-1-one, 4'-acetyl-3,3',5,5',6,6',7,7'-octahydro- 382664 NSC670312 sensitive
hsa-miR-539-5p 2,3-dibenzoyloxy-4-hydroxy-4-oxobutanoate;(2,5-dimethylphenyl)-(4-methylphenyl)-phenylsulfanium 5351228 NSC116693 sensitive
hsa-miR-539-5p 2,5-dibenzyl-2-undecyloctahydro-1h-pyrrolo[3,4-c]pyridin-2-ium bromide 378731 NSC661832 sensitive
hsa-miR-539-5p 2,5,12-trimethyl-[1,4]benzodioxino[3,2-g]isoquinolin-2-ium acetate 388316 NSC683048 sensitive
hsa-miR-539-5p 2,6,13,17-tetrazaheptacyclo[15.12.0.01,25.03,16.05,14.07,12.018,23]nonacosa-3,5,7,9,11,13,15,18(23)-octaene 378784 NSC661960 sensitive
hsa-miR-539-5p 3-(3-fluorophenyl)-n-pyridin-3-yl-2h-pyrazolo[3,4-d][1,3]thiazol-5-amine 60147811 NSC752461 sensitive
hsa-miR-539-5p 3-(4-methoxyphenyl)-4-methyl-8-pyrrolidin-1-yl-8H-thieno[2,3-b]pyrrolizin-4-ium;iodide 388538 NSC683518 sensitive
hsa-miR-539-5p 3-amino-4-(1,3-benzothiazol-2-yl)-7-nitro-2-(1-phenylethyl)isoquinolin-1-one 391659 NSC691201 sensitive
hsa-miR-539-5p 3-nitro-5-oxo-7h-benzimidazolo[1,2-a]quinoline-6-carbonitrile 391674 NSC691216 sensitive
hsa-miR-539-5p 3,3'-diethyl-9-methylthiacarbocyanine iodide 5351210 NSC96932 sensitive
hsa-miR-539-5p 3,3-bis(3-(trifluoromethyl)phenyl)naphtho[1,2-c]furan-1(3h)-one 362080 NSC625603 sensitive
hsa-miR-539-5p 3,4,7-trichloro-n,n-bis(2-chloroethyl)-11-oxobenzo[d][1,3,6,2]benzodioxathiaphosphocin-11-amine 382835 NSC670664 sensitive
hsa-miR-539-5p 4-(3h-[1,3]thiazolo[3,4-a]benzimidazol-1-yl)phenyl acetate 384820 NSC675272 sensitive
hsa-miR-539-5p 4-(4-carbazol-9-ylbutanoylamino)-n-[5-[3-(dimethylamino)propylcarbamoyl]-1-methylpyrrol-3-yl]-1-methylpyrrole-2-carboxamide 406397 NSC724462 sensitive
hsa-miR-539-5p 4-(5-(4-(hydroxy(oxido)amino)phenyl)-2-furyl)-2-(4-toluidino)-1,3-thiazole 367868 NSC638034 sensitive
hsa-miR-539-5p 4-(bromomethyl)-2,2,5,5-tetramethyl-1-imidazolidinol 3-oxide 378673 NSC661470 resistant
hsa-miR-539-5p 4-[(13R)-13-hydroxy-13-[(2S,5S)-5-[(2S,5S)-5-[1-hydroxy-13-[(2S)-2-methyl-5-oxo-2H-furan-4-yl]tridecyl]oxolan-2-yl]oxolan-2-yl]tridecyl]-2-methyl-2H-furan-5-one 374064 NSC651320 sensitive
hsa-miR-539-5p 4-[(2z)-2-[3-butyl-4-(4-chlorophenyl)-1,3-thiazolidin-2-ylidene]hydrazinyl]-2h-phthalazin-1-one 9572675 NSC724117 sensitive
hsa-miR-539-5p 4-[(e)-2-[3-(4-chlorophenyl)-6a,10b-dimethyl-8-methylidene-1,4a,5,6,7,9,10,10a-octahydronaphtho[2,1-d][1,3]dioxin-7-yl]ethenyl]-2h-furan-5-one 54613025 NSC750038 sensitive
hsa-miR-539-5p 4-[[(4S,9aR)-9-(4-hydroxy-3,5-dimethoxyphenyl)-6,7-dimethoxy-1-oxo-3a,4,9,9a-tetrahydro-3H-benzo[f][2]benzofuran-4-yl]amino]benzonitrile 369961 NSC642328 sensitive
hsa-miR-539-5p 4-[[(Z)-N-benzamido-C-[4-[bis(2-cyanoethyl)amino]-2-methylphenyl]carbonimidoyl]diazenyl]benzoic acid 135493923 NSC681974 sensitive
hsa-miR-539-5p 4-methyl-1,1-diphenyl-1,2,3,4-tetrahydrobenzo(h)phosphinolinium hexafluorophosphate 498151 NSC245398 sensitive
hsa-miR-539-5p 4-naphthalen-2-yl-2,4-dioxo-3-(3-oxo-1H-2-benzofuran-1-yl)-N-[3-(trifluoromethyl)phenyl]butanamide 369471 NSC641241 sensitive
hsa-miR-539-5p 4-pyridin-3-yl-2-(2,3,5-trichlorophenyl)-1,3-thiazole 24814783 NSC742842 resistant
hsa-miR-539-5p 5-(4-chlorophenyl)-3-[3-[(E)-3-(4-hydroxy-3-methoxyphenyl)prop-2-enoyl]phenyl]-1H-imidazol-2-one 46919707 NSC748559 resistant
hsa-miR-539-5p 5-[(5s,8ar)-5-(4-fluoroanilino)-8-oxo-5a,6,8a,9-tetrahydro-5h-[2]benzofuro[6,5-f][1,3]benzodioxol-9-yl]-3-methoxycyclohexa-3,5-diene-1,2-dione 369957 NSC642324 sensitive
hsa-miR-539-5p 5-benzyl-5h-benzo[b]phosphindole 5-oxide 380786 NSC666496 sensitive
hsa-miR-539-5p 5-chroman-6-yl-2-(4-pyridyl)oxazole 380226 NSC665702 sensitive
hsa-miR-539-5p 5-hydroxy-3,7-dimethoxy-3',4'-methylenedioxyflavone 5466137 NSC678102 sensitive
hsa-miR-539-5p 5-methyl-2-{[(2)-3-phenylprop-2-enoyl]amino}benzamide 53329052 NSC748147 sensitive
hsa-miR-539-5p 5,10-dihydroxy-3-[[4-(2-hydroxyethyl)piperazin-1-yl]methyl]-1H-naphtho[2,3-f]indole-4,11-dione;hydrochloride 135585401 NSC726442 resistant
hsa-miR-539-5p 7'-but-3-en-2-yl-7'-(3-phenylmethoxypropyl)spiro[1,3-dioxolane-2,2'-3,4,7a,8,9,10-hexahydro-1h-cyclopenta[i]indolizine]-6'-thione 361486 NSC624523 sensitive
hsa-miR-539-5p 7-[(3-fluorophenyl)methoxy]-9-[(3-fluorophenyl)methyl]-2-[(4-fluorophenyl)methyl]-1-methylpyrido[3,4-b]indol-2-ium 54766740 NSC760181 sensitive
hsa-miR-539-5p 7-epi-3,4-bis-nor-dolastatin 11 396354 NSC702158 sensitive
hsa-miR-539-5p 8-(6-fluorohexyl)-3-methyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one;hydrochloride 380336 NSC665863 resistant
hsa-miR-539-5p 8-[3-(1,3-dioxolan-2-yl)-2-(4-fluorophenyl)propyl]-3-ethyl-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one;hydrochloride 380308 NSC665789 resistant
hsa-miR-539-5p 8-aminoadenosine 259812 NSC90394 resistant
hsa-miR-539-5p 8-benzyl-12-[2-(4-chloroanilino)-2-oxoethyl]sulfanyl-5-methyl-7-oxo-3-thia-1,8,10,11-tetrazatricyclo[7.3.0.02,6]dodeca-2(6),4,9,11-tetraene-4-carboxamide 155805059 NSC762858 sensitive
hsa-miR-539-5p 8b-hydroxy-9b,10b-epoxyverrucarin a 5351311 NSC328166 sensitive
hsa-miR-539-5p 9-((2-chloroethyl)thio)acridine 395387 NSC699923 resistant
hsa-miR-539-5p 9-bromo-2,3-dimethoxy-7,12-dihydro-5H-indolo[3,2-d][1]benzazepin-6-one 395805 NSC700693 resistant
hsa-miR-539-5p 9-chloro-12,13-dimethoxy-6-phenyl-2,10-diazatetracyclo[6.6.2.04,16.011,15]hexadeca-1(14),4(16),5,7,9,11(15),12-heptaen-3-one 5470922 NSC706236 resistant
hsa-miR-539-5p Baccharin 5358645 NSC269757 sensitive
hsa-miR-539-5p Berberine iodide 72350 NSC150446 sensitive
hsa-miR-539-5p Bis(trifluoromethylsulfonyl)azanide;trihexyl(tetradecyl)phosphanium 11181836 NSC747251 sensitive
hsa-miR-539-5p Blastmycin 245869 NSC58239 sensitive
hsa-miR-539-5p C12h8n2o2s 3838042 NSC675587 sensitive
hsa-miR-539-5p C22h12f6o6s2 389883 NSC686511 sensitive
hsa-miR-539-5p Carbon monoxide; cyclopentane; 1-ethoxy-3a-methyl-azulen-4-one; iron 499038 NSC649307 sensitive
hsa-miR-539-5p Cuspidatin c 5459164 NSC636859 sensitive
hsa-miR-539-5p Cytovaricin 5477715 NSC349622 sensitive
hsa-miR-539-5p Di-n-octyl-secalonsaure a 430141 NSC268925 sensitive
hsa-miR-539-5p Diethyl 4-hydroxy-2-(4-methoxyphenyl)-6-oxo-4-phenyl-1,3-cyclohexanedicarboxylate 386764 NSC679443 sensitive
hsa-miR-539-5p Diethylcyanine 5717105 NSC97374 sensitive
hsa-miR-539-5p Dimethyl (1s,7s,8s,9s,10s,12s)-9,10-diacetyloxy-11-[tert-butyl(dimethyl)silyl]oxy-7-phenylmethoxy-2-oxa-3-azatricyclo[6.3.1.04,12]dodec-3-ene-1,12-dicarboxylate 360859 NSC623520 sensitive
hsa-miR-539-5p Ethyl (E)-3-(6-methoxy-1-thiophen-3-yl-3,4-dihydronaphthalen-2-yl)prop-2-enoate 24205739 NSC736553 sensitive
hsa-miR-539-5p Euphorbia substance spr5 5459191 NSC640929 sensitive
hsa-miR-539-5p Heteromine a 391982 NSC691767 sensitive
hsa-miR-539-5p Indanthren corinth rk 5351878 NSC74702 sensitive
hsa-miR-539-5p Inosine, 6-thio-, 2',3',5'-tripentanoate 4208664 NSC77495 resistant
hsa-miR-539-5p Inostamycin 368135 NSC638478 sensitive
hsa-miR-539-5p Insariotoxin 6711181 NSC138780 sensitive
hsa-miR-539-5p Isobaccharin 5358646 NSC269760 sensitive
hsa-miR-539-5p Isobrucein a 322357 NSC279503 sensitive
hsa-miR-539-5p J3.522.543i 6163542 NSC113053 resistant
hsa-miR-539-5p Kinetin riboside 3832 NSC120958 resistant
hsa-miR-539-5p Laurusin 135476719 NSC106486 resistant
hsa-miR-539-5p Leucinostatine d 5459065 NSC608984 sensitive
hsa-miR-539-5p Maxima isoflavone d 343081 NSC382028 sensitive
hsa-miR-539-5p Methyl (1r,2s,3r,6r,13s,15r,17s)-10,15,16-trihydroxy-9,13-dimethyl-4,11-dioxo-3-[(z)-4,4,4-trifluoro-3-phenylbut-2-enoyl]oxy-5,18-dioxapentacyclo[12.5.0.01,6.02,17.08,13]nonadec-9-ene-17-carboxylate 5467619 NSC656901 sensitive
hsa-miR-539-5p Methyl 4-[3-(2-thienyl)quinoxalin-2-yl]oxybenzoate 388002 NSC682365 sensitive
hsa-miR-539-5p N-(6-methyl-1,3-benzothiazol-2-yl)-4-naphthalen-2-yl-2,4-dioxo-3-(3-oxo-1h-2-benzofuran-1-yl)butanamide 369455 NSC641225 sensitive
hsa-miR-539-5p N-benzyl-1-[10-[4-(benzylamino)-2-methylquinolin-1-ium-1-yl]decyl]-2-methylquinolin-1-ium-4-amine;perchlorate 387881 NSC682094 sensitive
hsa-miR-539-5p N,n-dimethyl-4-[(e)-2-(1-methyl-2,5-diphenylpyrazol-1-ium-3-yl)ethenyl]aniline;trifluoromethanesulfonate 5469868 NSC693576 sensitive
hsa-miR-539-5p Ncimech_000253 366144 NSC634471 sensitive
hsa-miR-539-5p NSC644919 NSC644919 sensitive
hsa-miR-539-5p NSC699071 NSC699071 sensitive
hsa-miR-539-5p NSC751830 NSC751830 resistant
hsa-miR-539-5p Oxidanium;1,3-diphenylpropane-1,3-dione;neodymium(3+);hydroxide 24202397 NSC647042 sensitive
hsa-miR-539-5p Phosphonium, triphenylpropenyl-, bromide, (e)- (8ci) 10714966 NSC289922 sensitive
hsa-miR-539-5p Propan-2-yl (3z)-4-benzyl-2,5-dioxo-6-[(2,4,5-trimethoxy-3-methylphenyl)methyl]-3-[(2,4,5-trimethoxy-3-methylphenyl)methylidene]piperazine-1-carboxylate 5387228 NSC622070 sensitive
hsa-miR-539-5p Propan-2-ylsulfanyl-(2,3,5,6-tetrachloropyridin-4-yl)sulfanylmethanethione 399833 NSC710969 resistant
hsa-miR-539-5p Propyl gallate 4947 NSC2626 resistant
hsa-miR-539-5p Pyrazolanthrone 8515 NSC75890 resistant
hsa-miR-539-5p Pyrimido[5,4-g]pteridine-2,4,6,8(1h,3h,7h,9h)-tetrone, 1,9-bis(methoxymethyl)-3,7-dimethyl-, 5-oxide 385097 NSC676032 sensitive
hsa-miR-539-5p Sarcoviolin 24202820 NSC726045 sensitive
hsa-miR-539-5p Sb-236687 17892742 NSC756422 resistant
hsa-miR-539-5p Sergeolide,desacetyl 125729 NSC364170 sensitive
hsa-miR-539-5p Stk366297 242249 NSC50648 sensitive
hsa-miR-539-5p Stl361983 256661 NSC83715 resistant
hsa-miR-539-5p Tetraoxo[?]dione 388215 NSC682809 sensitive
hsa-miR-539-5p Tris(1,10-phenanthroline)cerium(iii)-trithiocyanate 24202209 NSC632734 resistant
hsa-miR-539-5p Ursa-11,13(18)-dien-28-oic acid-3.beta.-ol 378695 NSC661747 sensitive
hsa-miR-539-5p Verapamil 2520 NSC272366 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-539-5p Doxorubicin 31703 NSC123127 approved resistant High Breast Cancer cell line (MCF-7)
hsa-miR-539-5p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer tissue
hsa-miR-539-5p Cisplatin 5460033 NSC119875 approved sensitive Low Non-Small Cell Lung Cancer cell line (A549, H1299)
hsa-miR-539-5p Vemurafenib 42611257 NSC761431 approved sensitive High Melanoma cell line (M14) (2uM)
hsa-miR-539-5p Trametinib 11707110 NSC758246 approved sensitive High Melanoma cell line (M14) (2uM)
hsa-miR-539-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-539-5p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-539-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-539-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-539-5p Testosterone+Tamoxifen sensitive cell line (MCF-7)
hsa-miR-539-5p Paclitaxel 36314 NSC125973 approved sensitive cell line (A2780)
hsa-miR-539-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (RPMI2650)
hsa-miR-539-5p Sunitinib 5329102 NSC750690 approved resistant tissue (CardA)
hsa-miR-539-5p Paclitaxel 36314 NSC125973 approved resistant cell line (SKOV3)
hsa-miR-539-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-539-5p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-539-5p Paclitaxel/Docetaxel/Vinorelbine/Doxorubicin/Etoposide sensitive cell line (Bads-200)

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