miRTarBase - #MIRT439312


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pre-miRNA Information
pre-miRNA hsa-mir-1185-1   
Genomic Coordinates chr14: 101042977 - 101043062
Synonyms MIRN1185-1, hsa-mir-1185-1, MIR1185-1
Description Homo sapiens miR-1185-1 stem-loop
Comment This sequence was proposed as a miRNA candidate by Berezikov et al by RAKE analysis .
RNA Secondary Structure

Mature miRNA Information
Mature miRNA hsa-miR-1185-1-3p
Sequence 53| AUAUACAGGGGGAGACUCUUAU |74
Evidence Not_experimental
Experiments
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 5 14 + 101043033 29233923 MiREDiBase
A-to-I 7 14 + 101043035 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs749794228 1 dbSNP
rs369414498 4 dbSNP
rs771096180 5 dbSNP
rs774958411 7 dbSNP
rs1226171972 11 dbSNP
rs1449899083 14 dbSNP
rs761183893 16 dbSNP
rs1380874583 20 dbSNP
rs771625921 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol VAT1L   
Synonyms -
Description vesicle amine transport 1 like
Transcript NM_020927   
Expression
Putative miRNA Targets on VAT1L
3'UTR of VAT1L
(miRNA target sites are highlighted)		 
>VAT1L|NM_020927|3'UTR
   1 CTGAGGACCCAGGTGGGAGAATGTGAAGGATGGTTTGGAAGATGAGGACCCGGCTGAGAAAACTCTTCTGTGCCCCAGTG
  81 AACAAATGCTGTAGTCCAGTGCGTGTCGTGTTTGTCTGCAGTCAGCTGAGCTAAAAAGCTGTTGATCACTGTTGTTTTTT
 161 GAAGTGCCAATCCCATGCCATGCAGTATTATGTCCCTCTCCTATCTGTGTATTACACATTCCCCTCTCCCCTGTATCAAA
 241 ACCATCCATCTGTGGGTTCTTCTTGACAGTTCTAGAACAGCCTTGCAAATTAATACAAGTCCCAGGCCCAATGCCTAAGA
 321 GACCAGACGTGGGCAAAGACAAGTTTGGATGGAAAGGTGTTATCACAGAGCCCTGTCCAGCTCCTAGAATTCCTCAGGCC
 401 AGTGACACTTTTTTGCTGCTGGCCACCCATGCCTCTGATGAGAACACTTGCCAATTTGGCCAGCAGAAAGAGAGTAGGCC
 481 GGATGTTTTCATGAGCCCACAAATTTAGAAACTCTCCTAGTAGTACTTTTTCTCTCTCCATTTAAGAGACAACTACGGTC
 561 AAAAGTTTGAGCCATTCTCTTCTACCCCTTCAGTGTCTGACCCTTTCACTGGCTCTTATCTGTAAACACAGGGAGGCAGG
 641 TATGGATTTTTCACAGTAGACAATGGGTCAACAGCATGAGTTTGAGGACCTGCTGTGAAGATTTCTCCTCCAAAATACAT
 721 CTCATGGGCAGGATTCTTCCTGCTCCATATCTGTTTCAATTTTAAGAAAGCACCACATACAAGACACATTCAGAAGTCAT
 801 TCCTGAGCATTGCTGGTGTTTGCACACTTGCCACCTGCATTACCAATTCTGTAAATTTCAATTCCTGGTGGAAAGTGACC
 881 ACTTTGACCATGGATTTCCCAAAGAAGAGTTCCTTTGCAGACCATAGGTGGAAAAGTCAATGAGCATCTCCTTCCTTGCC
 961 AAAGCATGTCCCAACATGTAACAAACTCTAGGGATACAAAAGGTTTATATTCAGCATCTGATGTCAGATGTACAGTTCCT
1041 CCCCTCCCATATATAAACCCCGGTGTAGAATCTGCAGCGCCCTGCTCTTCGGAAACCAAGGAACAAGCCACCTGCTCACA
1121 CACCTTGTTCAACTTTTCAGCTCCTAAGGAACCCCACCCCCATGCAATTTGACTGTGCTTGAGAGGTGAATACAGTTACC
1201 TTCGAGAAACAGAGGGAGCTCCTCACCCCGTCCTTCCAGTCCTTTTGGCTAAAATGCTTAACTATCACTCACAAACAAAT
1281 GTGGAGATACCAGGAGCTCATTTGATTCATACCCCAACTTTGTGTTCTGAAAAACATCAGAGGGATTTTACATTGCCCAG
1361 TTTCTCCACCAACAAGCCTTAGGGTGGACCCAACCCTTTCCGCAAGTGGTAGGAACGAATGCATCTTAGCAATTACCTGA
1441 TTTCCAAAGTCCTTTTGTAGCAAATGTCACCTCATTCGTGGTCTTTTTACCTATCCTAAGCTTATGATGATGAGTTATGT
1521 ATGCCAAATACTTATCTGAAGAGTTTCTCCTCATTGTGAATGTGTATGTAAAATATGAAGACAAGAAAGGGTGCTTTCAT
1601 CTGAGGAACCAAGGGGTGAGAGTATCCCAAAGGAGGACACCAGCATCATCTTTTCTTCGTACTCCAGGACCCACCAATAT
1681 TCCAGTTCTGGGTCATTTAGAGAGATAATGGGGCGTTTATTCCCCTATTACCTTTGCTAAGTGCTATATTATTGGCTGTT
1761 TCTCCCGTAACCATGCTGAAAAGGGGGTCTTAGGGAGAACTGTCATCCAAGTGGCATTCCTAGTAAGTTGGGTAGAAATG
1841 ACATTTTCCAGAGCTGAAGGAGTGAAGAGCCCTTGGCCATACTAGGGCTCTCCTTCCCCCGGGGAGTGGGAACTCAGCCA
1921 CATTCAGAATTCACATCGCCTTTGTTATGTCCAGAGGAGAGGCATAAAAAGGCACTCTCCCCCACCACCCCTACCAAATC
2001 TGGGTTTGGTTTGGTTTTATTTAACTAGCAAAGTTAATCCAGTAATCGCAAATTACTCCAGATGGTTAAAGAAAACCCTT
2081 TCAGAATACAGAACGAGAAAACTAGAGTTTGACCAATAAGACCAATTTCTGCCATGAAGAACCGGGGGACGCAAGTTAAT
2161 TGTTTAACGTACTCTCATTTTAAGCACCTTCTTTCCTGTCTCTTGATTGTTTTTTCTGAAGGAAGTGTAAAGAATGTCTC
2241 AGTCTGCCTTAAAGGAACTGTGAAGGCTTCTCTGTAATTTAAGCTTGATAGAAGTGAACTGAAACATTGTCTAATGTCTT
2321 TGTGGCTTTAGAGCTTTTGTTATATTGTGCCTATAAAGCAAATTATGTTTACATAAAAATATAAATAAAGTATTCAGCAT
2401 AGCAAAACCTCAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uauucucAGAGGG-GGACAUAUa 5'
                 |||||: :||||:|| 
Target 5' atgtcccTCTCCTATCTGTGTAt 3'
 190 - 212 143.00 -15.90
2 
miRNA  3' uauucucaGAG-GGGGACAUAua 5'
                  ||| |||||||||  
Target 5' acattcccCTCTCCCCTGTATca 3'
 216 - 238 142.00 -17.70
3 
miRNA  3' uauucuCAGAGGG-GGACAUAUa 5'
                | |||:: :||||| | 
Target 5' ttcactGGCTCTTATCTGTAAAc 3'
 605 - 627 120.00 -8.72
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30159144 11 COSMIC
COSN30179644 15 COSMIC
COSN26551056 18 COSMIC
COSN26548596 29 COSMIC
COSN30127086 34 COSMIC
COSN30155595 42 COSMIC
COSN9653055 56 COSMIC
COSN30142822 66 COSMIC
COSN30103661 67 COSMIC
COSN7272987 104 COSMIC
COSN31578223 109 COSMIC
COSN28680263 134 COSMIC
COSN20081883 138 COSMIC
COSN31486971 145 COSMIC
COSN17567852 146 COSMIC
COSN24305661 185 COSMIC
COSN7272988 264 COSMIC
COSN5837321 480 COSMIC
COSN8237920 528 COSMIC
COSN25219121 586 COSMIC
COSN7272989 670 COSMIC
COSN7272990 741 COSMIC
COSN20113114 800 COSMIC
COSN9653056 856 COSMIC
COSN7272991 909 COSMIC
COSN16966712 949 COSMIC
COSN17037770 1392 COSMIC
COSN31523331 1408 COSMIC
COSN31959690 1417 COSMIC
COSN31552318 1479 COSMIC
COSN15780104 1695 COSMIC
COSN7272992 1768 COSMIC
COSN25451514 1831 COSMIC
COSN20093167 1891 COSMIC
COSN7272993 2048 COSMIC
COSN21943526 2170 COSMIC
COSN26671395 2185 COSMIC
COSN31513724 2233 COSMIC
COSN16295721 2258 COSMIC
COSN31566462 2265 COSMIC
COSN28722248 2291 COSMIC
COSN8602089 2312 COSMIC
COSN17530395 2383 COSMIC
COSN31530243 2389 COSMIC
COSN19601836 2392 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs751372442 1 dbSNP
rs757011775 5 dbSNP
rs767255521 9 dbSNP
rs754079666 10 dbSNP
rs1410901393 13 dbSNP
rs755131982 14 dbSNP
rs957702150 15 dbSNP
rs1159507706 16 dbSNP
rs778861836 20 dbSNP
rs1435102932 22 dbSNP
rs752817056 24 dbSNP
rs377507276 26 dbSNP
rs747419102 29 dbSNP
rs146523587 40 dbSNP
rs781650021 42 dbSNP
rs572256945 43 dbSNP
rs745531725 44 dbSNP
rs989804143 47 dbSNP
rs769425319 52 dbSNP
rs1289262677 53 dbSNP
rs1253038844 54 dbSNP
rs968659306 56 dbSNP
rs1249373899 64 dbSNP
rs1020848074 66 dbSNP
rs1198108377 70 dbSNP
rs966607823 71 dbSNP
rs1462709377 75 dbSNP
rs187961895 76 dbSNP
rs1222700071 77 dbSNP
rs1329738305 78 dbSNP
rs538468160 79 dbSNP
rs993336946 80 dbSNP
rs1422464254 81 dbSNP
rs1195692293 84 dbSNP
rs908002989 86 dbSNP
rs1374154225 92 dbSNP
rs534907343 95 dbSNP
rs758149444 99 dbSNP
rs114374576 103 dbSNP
rs752155425 104 dbSNP
rs931291016 108 dbSNP
rs866049035 109 dbSNP
rs1049380373 110 dbSNP
rs1377939781 115 dbSNP
rs141077115 119 dbSNP
rs1187661550 120 dbSNP
rs767426500 122 dbSNP
rs1425141118 126 dbSNP
rs1007942549 128 dbSNP
rs1202769521 128 dbSNP
rs756092702 131 dbSNP
rs940276662 133 dbSNP
rs1269794656 150 dbSNP
rs1256049535 154 dbSNP
rs1046572999 160 dbSNP
rs1210853641 162 dbSNP
rs1035742912 165 dbSNP
rs891588876 175 dbSNP
rs1310923729 176 dbSNP
rs533923973 177 dbSNP
rs777542077 178 dbSNP
rs1322982159 183 dbSNP
rs1456065384 184 dbSNP
rs1384905524 193 dbSNP
rs1163297461 197 dbSNP
rs1473519723 205 dbSNP
rs1366336298 207 dbSNP
rs1002377507 209 dbSNP
rs1182530238 210 dbSNP
rs750668072 212 dbSNP
rs1033394034 224 dbSNP
rs1249617124 225 dbSNP
rs1021499576 227 dbSNP
rs113048595 229 dbSNP
rs1477680856 236 dbSNP
rs1192186474 240 dbSNP
rs1210498188 244 dbSNP
rs1432019975 246 dbSNP
rs1289687028 250 dbSNP
rs181228929 252 dbSNP
rs1366228623 254 dbSNP
rs555056584 257 dbSNP
rs1176070994 258 dbSNP
rs1020628713 265 dbSNP
rs966639965 279 dbSNP
rs1008805968 281 dbSNP
rs960321169 282 dbSNP
rs992887700 284 dbSNP
rs1391675072 285 dbSNP
rs1166461378 286 dbSNP
rs779839762 289 dbSNP
rs1290266153 294 dbSNP
rs753732739 295 dbSNP
rs545907783 302 dbSNP
rs1399146400 317 dbSNP
rs554839604 319 dbSNP
rs1018802973 320 dbSNP
rs1200827152 324 dbSNP
rs574664698 327 dbSNP
rs563032268 329 dbSNP
rs1221881727 330 dbSNP
rs1300744019 334 dbSNP
rs1277091892 338 dbSNP
rs940807275 339 dbSNP
rs1339209982 340 dbSNP
rs778710705 349 dbSNP
rs1344207500 351 dbSNP
rs1301956962 352 dbSNP
rs1409956626 355 dbSNP
rs747237499 357 dbSNP
rs1372008530 358 dbSNP
rs921325393 361 dbSNP
rs1409013104 362 dbSNP
rs952900451 364 dbSNP
rs576132569 365 dbSNP
rs113460428 367 dbSNP
rs561822061 371 dbSNP
rs908533799 372 dbSNP
rs940309299 373 dbSNP
rs1483454339 378 dbSNP
rs943697307 394 dbSNP
rs185434699 399 dbSNP
rs547372547 401 dbSNP
rs928122984 402 dbSNP
rs1010015721 406 dbSNP
rs1430922386 409 dbSNP
rs1221337317 416 dbSNP
rs1021445801 423 dbSNP
rs1283274030 427 dbSNP
rs1213352911 428 dbSNP
rs374554891 431 dbSNP
rs1228469472 433 dbSNP
rs938156147 439 dbSNP
rs1001425861 442 dbSNP
rs1034684803 444 dbSNP
rs1380483397 447 dbSNP
rs960023260 448 dbSNP
rs1055692661 460 dbSNP
rs1159902961 463 dbSNP
rs1473533170 465 dbSNP
rs1414216090 471 dbSNP
rs1296050249 472 dbSNP
rs543165461 478 dbSNP
rs1337820291 479 dbSNP
rs1014901333 481 dbSNP
rs435730 482 dbSNP
rs1460314424 487 dbSNP
rs1042104116 493 dbSNP
rs902151459 494 dbSNP
rs533027382 496 dbSNP
rs1353173769 501 dbSNP
rs148967714 512 dbSNP
rs1294480075 513 dbSNP
rs1222747867 518 dbSNP
rs143704542 521 dbSNP
rs748212529 529 dbSNP
rs1285649452 535 dbSNP
rs1450173773 541 dbSNP
rs1322694995 556 dbSNP
rs1221533887 557 dbSNP
rs569761363 558 dbSNP
rs953672360 564 dbSNP
rs986353456 566 dbSNP
rs576370809 578 dbSNP
rs538054209 580 dbSNP
rs912119991 581 dbSNP
rs945003676 583 dbSNP
rs1438754305 585 dbSNP
rs996060109 586 dbSNP
rs912923149 595 dbSNP
rs773582631 603 dbSNP
rs1156450964 610 dbSNP
rs1189643102 612 dbSNP
rs1415740424 614 dbSNP
rs952851967 618 dbSNP
rs1259530902 619 dbSNP
rs1405714315 620 dbSNP
rs984159049 622 dbSNP
rs405764 625 dbSNP
rs1291406830 628 dbSNP
rs1250364433 634 dbSNP
rs409260 638 dbSNP
rs138355165 640 dbSNP
rs1437071407 641 dbSNP
rs1001772389 656 dbSNP
rs1288290006 657 dbSNP
rs1376237279 658 dbSNP
rs111871756 660 dbSNP
rs1350485735 666 dbSNP
rs928269576 667 dbSNP
rs1422929263 668 dbSNP
rs1384886946 673 dbSNP
rs1317391685 675 dbSNP
rs1430723775 676 dbSNP
rs556549512 678 dbSNP
rs938258698 681 dbSNP
rs190682510 682 dbSNP
rs1489100233 683 dbSNP
rs915381672 688 dbSNP
rs962025437 690 dbSNP
rs117559201 691 dbSNP
rs759210728 693 dbSNP
rs1258214924 694 dbSNP
rs953520200 696 dbSNP
rs1387232798 701 dbSNP
rs986689587 702 dbSNP
rs767134731 703 dbSNP
rs1403229530 705 dbSNP
rs902184107 708 dbSNP
rs539474974 737 dbSNP
rs1176446107 743 dbSNP
rs547667276 746 dbSNP
rs1238794772 748 dbSNP
rs1170214835 749 dbSNP
rs1434230401 758 dbSNP
rs912089334 762 dbSNP
rs1196633285 770 dbSNP
rs143838699 774 dbSNP
rs988406958 778 dbSNP
rs1197126081 782 dbSNP
rs559402709 799 dbSNP
rs1250509217 801 dbSNP
rs945699062 806 dbSNP
rs576517964 807 dbSNP
rs1281361768 809 dbSNP
rs996479579 812 dbSNP
rs746332490 813 dbSNP
rs1171295679 814 dbSNP
rs1027519653 816 dbSNP
rs1344889307 828 dbSNP
rs1464112824 836 dbSNP
rs1393309040 839 dbSNP
rs1242317282 843 dbSNP
rs3751770 844 dbSNP
rs1297942877 852 dbSNP
rs1466928198 858 dbSNP
rs147238744 868 dbSNP
rs1447773795 878 dbSNP
rs1174826219 888 dbSNP
rs1056010714 890 dbSNP
rs1282849584 891 dbSNP
rs1364513908 892 dbSNP
rs895663437 895 dbSNP
rs866376567 914 dbSNP
rs1014552487 920 dbSNP
rs1219822024 922 dbSNP
rs1200804286 924 dbSNP
rs1015596369 926 dbSNP
rs961430786 929 dbSNP
rs982115471 931 dbSNP
rs139367345 935 dbSNP
rs576590605 936 dbSNP
rs897784764 941 dbSNP
rs1268807079 955 dbSNP
rs994787930 959 dbSNP
rs1306642431 966 dbSNP
rs959676937 970 dbSNP
rs1027638380 971 dbSNP
rs141568673 973 dbSNP
rs760173293 978 dbSNP
rs946827039 979 dbSNP
rs1159768416 980 dbSNP
rs150889966 988 dbSNP
rs867917196 990 dbSNP
rs1451064886 991 dbSNP
rs1362852969 993 dbSNP
rs1280301738 996 dbSNP
rs532937454 997 dbSNP
rs923720040 998 dbSNP
rs181776039 999 dbSNP
rs966245915 1000 dbSNP
rs1040064272 1007 dbSNP
rs1206970812 1008 dbSNP
rs1194366649 1012 dbSNP
rs1260236224 1013 dbSNP
rs542016127 1018 dbSNP
rs1361906356 1024 dbSNP
rs1422775952 1030 dbSNP
rs1313337232 1031 dbSNP
rs528993497 1034 dbSNP
rs978411435 1036 dbSNP
rs1381025148 1043 dbSNP
rs1383539757 1044 dbSNP
rs925659149 1049 dbSNP
rs1426120675 1051 dbSNP
rs931932368 1052 dbSNP
rs372083542 1061 dbSNP
rs991260704 1062 dbSNP
rs1128695 1063 dbSNP
rs568330779 1064 dbSNP
rs887616814 1066 dbSNP
rs1446384240 1067 dbSNP
rs527913080 1068 dbSNP
rs1261085737 1070 dbSNP
rs186600624 1079 dbSNP
rs3751771 1080 dbSNP
rs569692417 1081 dbSNP
rs1035039655 1085 dbSNP
rs539439574 1086 dbSNP
rs367834862 1091 dbSNP
rs556527557 1092 dbSNP
rs778601832 1099 dbSNP
rs1216269054 1100 dbSNP
rs1276168031 1102 dbSNP
rs74760712 1104 dbSNP
rs1303195936 1105 dbSNP
rs867202992 1108 dbSNP
rs1302071252 1116 dbSNP
rs1049511115 1117 dbSNP
rs1421330432 1118 dbSNP
rs1165976744 1120 dbSNP
rs1218322013 1122 dbSNP
rs535969422 1124 dbSNP
rs889138279 1127 dbSNP
rs1008024955 1129 dbSNP
rs1022935967 1138 dbSNP
rs149603306 1153 dbSNP
rs978295499 1159 dbSNP
rs901964176 1160 dbSNP
rs192387283 1166 dbSNP
rs541257834 1168 dbSNP
rs944469714 1180 dbSNP
rs748300186 1182 dbSNP
rs1216982135 1188 dbSNP
rs769780914 1189 dbSNP
rs976211279 1204 dbSNP
rs1021162409 1211 dbSNP
rs1487237445 1225 dbSNP
rs183655213 1230 dbSNP
rs979693016 1231 dbSNP
rs186830210 1233 dbSNP
rs958400969 1235 dbSNP
rs1402813169 1244 dbSNP
rs1178412821 1258 dbSNP
rs991601379 1263 dbSNP
rs1477733902 1265 dbSNP
rs1427229721 1271 dbSNP
rs1198827667 1279 dbSNP
rs1171053201 1282 dbSNP
rs1234861333 1283 dbSNP
rs749794714 1286 dbSNP
rs1437543994 1287 dbSNP
rs771421570 1288 dbSNP
rs1382332613 1289 dbSNP
rs909169996 1291 dbSNP
rs1297921154 1294 dbSNP
rs189822102 1297 dbSNP
rs919108024 1298 dbSNP
rs1389075186 1311 dbSNP
rs1036180050 1313 dbSNP
rs1324776168 1316 dbSNP
rs930535290 1316 dbSNP
rs1441028830 1319 dbSNP
rs1383174511 1326 dbSNP
rs1338478642 1327 dbSNP
rs1468130419 1328 dbSNP
rs1139933 1330 dbSNP
rs879039654 1332 dbSNP
rs1175420030 1337 dbSNP
rs1435051005 1338 dbSNP
rs1401416247 1339 dbSNP
rs146213276 1342 dbSNP
rs1355352413 1344 dbSNP
rs1240624419 1347 dbSNP
rs1469837484 1350 dbSNP
rs1056912109 1353 dbSNP
rs1285099032 1356 dbSNP
rs1185858373 1360 dbSNP
rs895156537 1361 dbSNP
rs112762734 1371 dbSNP
rs1215881677 1374 dbSNP
rs1267906078 1375 dbSNP
rs1323749908 1377 dbSNP
rs1451117453 1383 dbSNP
rs1318127439 1392 dbSNP
rs1281540890 1395 dbSNP
rs901915994 1402 dbSNP
rs1022302584 1403 dbSNP
rs1316851074 1404 dbSNP
rs1450244480 1407 dbSNP
rs1440603304 1408 dbSNP
rs1289309927 1409 dbSNP
rs1432825258 1411 dbSNP
rs968313734 1413 dbSNP
rs999766701 1414 dbSNP
rs1042550238 1416 dbSNP
rs904028879 1417 dbSNP
rs1386151229 1418 dbSNP
rs1378925420 1429 dbSNP
rs1031189025 1434 dbSNP
rs1164354651 1446 dbSNP
rs1443247089 1450 dbSNP
rs1390558385 1456 dbSNP
rs1413527902 1466 dbSNP
rs1187551089 1470 dbSNP
rs1404272424 1475 dbSNP
rs182851400 1478 dbSNP
rs1214503546 1479 dbSNP
rs547622518 1482 dbSNP
rs1243492305 1483 dbSNP
rs570766480 1496 dbSNP
rs1378441823 1501 dbSNP
rs775109285 1504 dbSNP
rs921644876 1505 dbSNP
rs1359830997 1509 dbSNP
rs953151171 1510 dbSNP
rs984886191 1515 dbSNP
rs908867857 1516 dbSNP
rs10514434 1521 dbSNP
rs549881068 1522 dbSNP
rs1355494648 1525 dbSNP
rs398765 1532 dbSNP
rs1368204340 1549 dbSNP
rs919059235 1551 dbSNP
rs776165294 1555 dbSNP
rs951887227 1556 dbSNP
rs1192285113 1561 dbSNP
rs985070893 1565 dbSNP
rs910463332 1569 dbSNP
rs139170231 1575 dbSNP
rs1040358841 1577 dbSNP
rs761674720 1588 dbSNP
rs1178321327 1589 dbSNP
rs923286436 1590 dbSNP
rs372987102 1595 dbSNP
rs1346163729 1601 dbSNP
rs895260948 1611 dbSNP
rs1403290120 1616 dbSNP
rs1425928052 1619 dbSNP
rs35693304 1620 dbSNP
rs429536 1620 dbSNP
rs1368418390 1621 dbSNP
rs1456880419 1623 dbSNP
rs1463901983 1630 dbSNP
rs1353265783 1636 dbSNP
rs1043779746 1641 dbSNP
rs903828995 1644 dbSNP
rs534801324 1645 dbSNP
rs1470602280 1648 dbSNP
rs766221127 1651 dbSNP
rs966247366 1659 dbSNP
rs758257289 1660 dbSNP
rs1250871668 1663 dbSNP
rs1432214455 1663 dbSNP
rs1465640478 1666 dbSNP
rs895379276 1669 dbSNP
rs998129808 1671 dbSNP
rs1330274778 1674 dbSNP
rs1257208624 1677 dbSNP
rs528445028 1683 dbSNP
rs557994225 1686 dbSNP
rs1014271172 1687 dbSNP
rs1325620958 1688 dbSNP
rs1023894529 1689 dbSNP
rs766221611 1692 dbSNP
rs143997107 1700 dbSNP
rs984474952 1705 dbSNP
rs113851954 1707 dbSNP
rs1453960274 1707 dbSNP
rs961649225 1708 dbSNP
rs1409006214 1711 dbSNP
rs574703564 1713 dbSNP
rs1363886701 1714 dbSNP
rs928589608 1715 dbSNP
rs557006947 1716 dbSNP
rs1318709029 1722 dbSNP
rs984628362 1728 dbSNP
rs910400582 1731 dbSNP
rs1198796255 1732 dbSNP
rs537205558 1740 dbSNP
rs542304770 1742 dbSNP
rs1261400336 1745 dbSNP
rs369802894 1747 dbSNP
rs1315396638 1752 dbSNP
rs1308962769 1755 dbSNP
rs1453912488 1757 dbSNP
rs915734637 1760 dbSNP
rs1385617150 1765 dbSNP
rs1335239898 1767 dbSNP
rs187073687 1768 dbSNP
rs976419143 1775 dbSNP
rs777738464 1777 dbSNP
rs1043811055 1778 dbSNP
rs903860277 1784 dbSNP
rs192966552 1785 dbSNP
rs1052430892 1786 dbSNP
rs902114558 1787 dbSNP
rs749365426 1788 dbSNP
rs185338642 1790 dbSNP
rs16946927 1795 dbSNP
rs1169284629 1796 dbSNP
rs533426350 1801 dbSNP
rs1473978156 1805 dbSNP
rs779389199 1809 dbSNP
rs961761132 1810 dbSNP
rs1361969952 1815 dbSNP
rs1282820489 1816 dbSNP
rs868862824 1818 dbSNP
rs971743591 1820 dbSNP
rs1035345121 1821 dbSNP
rs142219493 1822 dbSNP
rs1412635695 1830 dbSNP
rs897454650 1839 dbSNP
rs1303309337 1843 dbSNP
rs1426175939 1850 dbSNP
rs746288025 1861 dbSNP
rs1162475903 1870 dbSNP
rs1475688198 1871 dbSNP
rs991394630 1873 dbSNP
rs915749687 1883 dbSNP
rs1195412461 1884 dbSNP
rs1476845396 1888 dbSNP
rs947203793 1891 dbSNP
rs887516973 1894 dbSNP
rs1490912151 1898 dbSNP
rs1288125509 1899 dbSNP
rs979522554 1901 dbSNP
rs1293581674 1902 dbSNP
rs749478502 1904 dbSNP
rs925394903 1907 dbSNP
rs964903783 1908 dbSNP
rs975979922 1910 dbSNP
rs1339202205 1919 dbSNP
rs1255572412 1923 dbSNP
rs1030245992 1926 dbSNP
rs935381987 1927 dbSNP
rs772437846 1928 dbSNP
rs563858641 1936 dbSNP
rs1484899836 1938 dbSNP
rs545159978 1939 dbSNP
rs978066350 1940 dbSNP
rs933584694 1943 dbSNP
rs746670850 1944 dbSNP
rs1166032661 1948 dbSNP
rs1465063459 1949 dbSNP
rs1050659617 1951 dbSNP
rs925289787 1955 dbSNP
rs1200275154 1956 dbSNP
rs10514435 1957 dbSNP
rs1006379213 1960 dbSNP
rs188257623 1964 dbSNP
rs916716471 1966 dbSNP
rs193255335 1971 dbSNP
rs1317870822 1972 dbSNP
rs1046584876 1974 dbSNP
rs1176348997 1979 dbSNP
rs1376648967 1981 dbSNP
rs572083760 1984 dbSNP
rs1160179673 1995 dbSNP
rs1128690 1997 dbSNP
rs1047363039 2000 dbSNP
rs1399364826 2003 dbSNP
rs551574922 2005 dbSNP
rs151206757 2007 dbSNP
rs1387362916 2019 dbSNP
rs1017768621 2028 dbSNP
rs1423155666 2029 dbSNP
rs1022849630 2034 dbSNP
rs1234919395 2035 dbSNP
rs968607096 2036 dbSNP
rs1177214371 2041 dbSNP
rs1457701500 2048 dbSNP
rs184549729 2049 dbSNP
rs557217564 2050 dbSNP
rs188312232 2057 dbSNP
rs966591450 2058 dbSNP
rs978015406 2067 dbSNP
rs535803229 2074 dbSNP
rs988205056 2075 dbSNP
rs28489142 2076 dbSNP
rs1248903122 2078 dbSNP
rs958284060 2090 dbSNP
rs923285851 2095 dbSNP
rs1191227069 2096 dbSNP
rs1357449934 2105 dbSNP
rs1333627117 2108 dbSNP
rs916646445 2111 dbSNP
rs949527767 2114 dbSNP
rs1252013583 2115 dbSNP
rs779508061 2117 dbSNP
rs1050845683 2120 dbSNP
rs918773947 2123 dbSNP
rs930201295 2134 dbSNP
rs910829431 2136 dbSNP
rs942284545 2141 dbSNP
rs1037868106 2143 dbSNP
rs1448353261 2144 dbSNP
rs552550230 2144 dbSNP
rs140307527 2145 dbSNP
rs993210143 2148 dbSNP
rs1215455042 2149 dbSNP
rs561211479 2149 dbSNP
rs180826503 2151 dbSNP
rs895482777 2152 dbSNP
rs1012611882 2156 dbSNP
rs544721062 2161 dbSNP
rs530241444 2163 dbSNP
rs1351509294 2169 dbSNP
rs370158206 2170 dbSNP
rs997282799 2177 dbSNP
rs1293068335 2185 dbSNP
rs1296516376 2186 dbSNP
rs1368838947 2191 dbSNP
rs1419349770 2193 dbSNP
rs1449363967 2197 dbSNP
rs1023032671 2199 dbSNP
rs902353975 2203 dbSNP
rs564867278 2204 dbSNP
rs578110122 2206 dbSNP
rs1422554762 2207 dbSNP
rs968659383 2208 dbSNP
rs1186591395 2212 dbSNP
rs766311698 2220 dbSNP
rs1222357727 2222 dbSNP
rs747415878 2233 dbSNP
rs1490420982 2240 dbSNP
rs1322795216 2244 dbSNP
rs1219169156 2248 dbSNP
rs1321044809 2250 dbSNP
rs1273543508 2252 dbSNP
rs549914918 2259 dbSNP
rs1031513825 2261 dbSNP
rs371100981 2267 dbSNP
rs958016925 2271 dbSNP
rs373657771 2276 dbSNP
rs1295633836 2279 dbSNP
rs756341188 2284 dbSNP
rs1466742954 2286 dbSNP
rs1180183607 2290 dbSNP
rs9711 2291 dbSNP
rs1420786484 2295 dbSNP
rs1192351184 2297 dbSNP
rs970762948 2299 dbSNP
rs1469470673 2301 dbSNP
rs35557214 2302 dbSNP
rs1175219394 2303 dbSNP
rs1269093476 2308 dbSNP
rs982175344 2310 dbSNP
rs1488001520 2315 dbSNP
rs1415672306 2323 dbSNP
rs923410281 2324 dbSNP
rs1206488033 2327 dbSNP
rs918721726 2328 dbSNP
rs954940224 2332 dbSNP
rs1324536510 2342 dbSNP
rs1424369893 2347 dbSNP
rs1385326575 2350 dbSNP
rs1164126263 2381 dbSNP
rs1299131213 2398 dbSNP
rs986188286 2398 dbSNP
rs1449614181 2401 dbSNP
rs368372162 2403 dbSNP
rs942989903 2404 dbSNP
rs1469806405 2412 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
114 hsa-miR-1185-1-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT066415 TBK1 TANK binding kinase 1 2 4
MIRT073567 NR2F2 nuclear receptor subfamily 2 group F member 2 2 2
MIRT074516 USP1 ubiquitin specific peptidase 1 2 4
MIRT080576 PMAIP1 phorbol-12-myristate-13-acetate-induced protein 1 2 6
MIRT086539 HSPE1-MOB4 HSPE1-MOB4 readthrough 2 2
MIRT086547 MOB4 MOB family member 4, phocein 2 2
MIRT088684 EML4 echinoderm microtubule associated protein like 4 2 4
MIRT090811 MBNL1 muscleblind like splicing regulator 1 2 4
MIRT095500 PURA purine rich element binding protein A 2 2
MIRT109530 KLHL15 kelch like family member 15 2 6
MIRT109807 ZFX zinc finger protein, X-linked 2 2
MIRT117888 ZBTB7A zinc finger and BTB domain containing 7A 2 2
MIRT120273 GSK3B glycogen synthase kinase 3 beta 2 4
MIRT149892 LDLR low density lipoprotein receptor 2 2
MIRT178475 LCOR ligand dependent nuclear receptor corepressor 2 4
MIRT193445 RORA RAR related orphan receptor A 2 2
MIRT198527 DSG2 desmoglein 2 2 2
MIRT226427 TP53INP1 tumor protein p53 inducible nuclear protein 1 2 2
MIRT227669 SET SET nuclear proto-oncogene 2 2
MIRT320405 HOXA9 homeobox A9 2 2
MIRT407774 MRPL35 mitochondrial ribosomal protein L35 2 2
MIRT439228 ZMIZ1 zinc finger MIZ-type containing 1 1 1
MIRT439312 VAT1L vesicle amine transport 1 like 1 1
MIRT439421 TMOD1 tropomodulin 1 1 1
MIRT439446 TMEM104 transmembrane protein 104 1 1
MIRT439524 STIM2 stromal interaction molecule 2 1 1
MIRT439612 SLC29A1 solute carrier family 29 member 1 (Augustine blood group) 1 1
MIRT439997 PFKFB2 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 2 1 1
MIRT440017 PCSK1 proprotein convertase subtilisin/kexin type 1 1 1
MIRT440131 NCOA4 nuclear receptor coactivator 4 1 1
MIRT440311 LRRC1 leucine rich repeat containing 1 1 1
MIRT440475 IAPP islet amyloid polypeptide 1 1
MIRT440511 HERC2 HECT and RLD domain containing E3 ubiquitin protein ligase 2 1 1
MIRT440617 FOXA2 forkhead box A2 1 1
MIRT440666 FBXL16 F-box and leucine rich repeat protein 16 1 1
MIRT440705 ERO1LB endoplasmic reticulum oxidoreductase 1 beta 1 1
MIRT441007 CAPZA2 capping actin protein of muscle Z-line alpha subunit 2 1 1
MIRT441018 CAND1 cullin associated and neddylation dissociated 1 1 1
MIRT441062 C1orf43 chromosome 1 open reading frame 43 1 1
MIRT441209 ARCN1 archain 1 1 1
MIRT449461 HAT1 histone acetyltransferase 1 2 2
MIRT467104 SRI sorcin 2 2
MIRT468060 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 10
MIRT468476 SESN3 sestrin 3 2 4
MIRT473533 MAX MYC associated factor X 2 2
MIRT473852 MAP2K4 mitogen-activated protein kinase kinase 4 2 2
MIRT474711 KIF13A kinesin family member 13A 2 6
MIRT481665 ARAP2 ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 2 2 2
MIRT485120 SF3B3 splicing factor 3b subunit 3 2 2
MIRT493055 MTFR1 mitochondrial fission regulator 1 2 2
MIRT504258 C1orf147 chromosome 1 open reading frame 147 2 4
MIRT504361 ARID1B AT-rich interaction domain 1B 2 4
MIRT505748 SENP1 SUMO1/sentrin specific peptidase 1 2 8
MIRT506298 PCMTD1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 2 6
MIRT508442 ZNF608 zinc finger protein 608 2 4
MIRT512782 COL4A3BP collagen type IV alpha 3 binding protein 2 2
MIRT520447 TSPAN2 tetraspanin 2 2 4
MIRT522133 NRBF2 nuclear receptor binding factor 2 2 6
MIRT522395 MYADM myeloid associated differentiation marker 2 4
MIRT523397 GRIK3 glutamate ionotropic receptor kainate type subunit 3 2 4
MIRT523938 E2F8 E2F transcription factor 8 2 4
MIRT524349 CREB1 cAMP responsive element binding protein 1 2 2
MIRT524711 BRMS1L breast cancer metastasis-suppressor 1 like 2 4
MIRT525134 ZNF256 zinc finger protein 256 2 2
MIRT525710 DCAF12L2 DDB1 and CUL4 associated factor 12 like 2 2 2
MIRT531264 PPIL3 peptidylprolyl isomerase like 3 2 2
MIRT538844 BTG1 BTG anti-proliferation factor 1 2 2
MIRT541366 CDKN1B cyclin dependent kinase inhibitor 1B 2 2
MIRT542093 KCNK10 potassium two pore domain channel subfamily K member 10 2 6
MIRT543770 RBM12B RNA binding motif protein 12B 2 4
MIRT543940 NCOA7 nuclear receptor coactivator 7 2 2
MIRT545150 GABRG1 gamma-aminobutyric acid type A receptor gamma1 subunit 2 2
MIRT545842 ZNF264 zinc finger protein 264 2 4
MIRT548057 GOLGA7 golgin A7 2 2
MIRT549242 ATXN1L ataxin 1 like 2 4
MIRT551829 AASDHPPT aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase 2 2
MIRT552484 ZNF136 zinc finger protein 136 2 2
MIRT553663 TGFBR2 transforming growth factor beta receptor 2 2 2
MIRT554988 RAB39B RAB39B, member RAS oncogene family 2 2
MIRT555760 PCTP phosphatidylcholine transfer protein 2 2
MIRT556923 IRF2BP2 interferon regulatory factor 2 binding protein 2 2 4
MIRT564991 WNK1 WNK lysine deficient protein kinase 1 2 2
MIRT566458 PGGT1B protein geranylgeranyltransferase type I subunit beta 2 2
MIRT566538 PANK3 pantothenate kinase 3 2 2
MIRT567732 DLX2 distal-less homeobox 2 2 2
MIRT570081 KANSL1L KAT8 regulatory NSL complex subunit 1 like 2 2
MIRT571735 RNF11 ring finger protein 11 2 2
MIRT573529 MDM2 MDM2 proto-oncogene 2 2
MIRT574459 RPS16 ribosomal protein S16 2 2
MIRT574992 Phka1 phosphorylase kinase alpha 1 2 3
MIRT576349 Pxdn peroxidasin 2 2
MIRT610196 CD99 CD99 molecule (Xg blood group) 2 4
MIRT612920 GPRIN3 GPRIN family member 3 2 2
MIRT615021 DUSP6 dual specificity phosphatase 6 2 2
MIRT623573 IRS1 insulin receptor substrate 1 2 2
MIRT624437 CASD1 CAS1 domain containing 1 2 2
MIRT628714 ZNF585A zinc finger protein 585A 2 2
MIRT639565 PCK1 phosphoenolpyruvate carboxykinase 1 2 4
MIRT641485 POLA2 DNA polymerase alpha 2, accessory subunit 2 2
MIRT641657 PAPOLG poly(A) polymerase gamma 2 2
MIRT642210 RUVBL2 RuvB like AAA ATPase 2 2 2
MIRT653010 STX7 syntaxin 7 2 2
MIRT656130 MSH6 mutS homolog 6 2 2
MIRT656893 KIAA2018 upstream transcription factor family member 3 2 2
MIRT660130 BRPF3 bromodomain and PHD finger containing 3 2 2
MIRT660855 AFAP1 actin filament associated protein 1 2 2
MIRT676843 PHKA1 phosphorylase kinase regulatory subunit alpha 1 2 3
MIRT681473 DIP2A disco interacting protein 2 homolog A 2 2
MIRT682253 RS1 retinoschisin 1 2 2
MIRT694296 COPB2 coatomer protein complex subunit beta 2 2 2
MIRT694401 ALDH1A3 aldehyde dehydrogenase 1 family member A3 2 2
MIRT705277 BACH1 BTB domain and CNC homolog 1 2 2
MIRT720833 C1orf52 chromosome 1 open reading frame 52 2 2
MIRT735713 SIRT1 sirtuin 1 2 0
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-1185-1 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-1185-1 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-1185-1-3p Platinum 23939 sensitive High Ovarian Cancer tissue
hsa-miR-1185-1-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-1185-1-3p Temozolomide 5394 NSC362856 approved resistant cell line (U251)
hsa-miR-1185-1-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-1185-1-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-1185-1-3p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-1185-1-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-1185-1-3p Prednisone/Azathioprine/Methotrexate/Cyclophosphamide/Mycophenolate mofetil sensitive tissue (myasthenia gravis)
hsa-miR-1185-1-3p Paclitaxel 36314 NSC125973 approved sensitive cell line (BAS)
hsa-miR-1185-1-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (BAS)
hsa-miR-1185-1-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (HS578T)
hsa-miR-1185-1-3p Tamoxifen+Fulvestrant resistant cell line (LCC9)
hsa-miR-1185-1-3p Osimertinib 71496458 NSC779217 approved resistant cell line (H1975)
hsa-miR-1185-1-3p Paclitaxel 36314 NSC125973 approved resistant cell line (A2780)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A2780)
hsa-miR-1185-1-3p Gemcitabine 60750 NSC613327 approved resistant cell line (MDA-231)
hsa-miR-1185-1-3p Gemcitabine 60750 NSC613327 approved sensitive cell line (PANC-1) (100 ng/ml)
hsa-miR-1185-1-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved resistant cell line (A549)
hsa-miR-1185-1-3p Cisplatin 5460033 NSC119875 approved resistant cell line (TOV-112D)

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