miRTarBase - #MIRT439324


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pre-miRNA Information
pre-miRNA hsa-mir-127   
Genomic Coordinates chr14: 100882979 - 100883075
Description Homo sapiens miR-127 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-127-5p
Sequence 23| CUGAAGCUCAGAGGGCUCUGAU |44
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM9722115 13 COSMIC
COSM7115045 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs867796380 11 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol USP34   
Synonyms -
Description ubiquitin specific peptidase 34
Transcript NM_014709   
Expression
Putative miRNA Targets on USP34
3'UTR of USP34
(miRNA target sites are highlighted)		 
>USP34|NM_014709|3'UTR
   1 CATTAGGTGTAGCATGTCTACTTTTAAGTCCCTCACCCCCAACCCCCATGCTGTTTGTATAAGTTTTGCTTATTTGTTTT
  81 TGTGCTTCAGTTTGTCCAGTGCTCTCTGCTTGAATGGCAAGATAGATTTATAGGCTTAATTCTTGGTCAGGCAGAACTCC
 161 AGATGAAAAAAACTTGCATCTTCAGTATACTTCCTAAAGGGCAATCAGATAATGGATATGTTTTATGTAATTAAGAGTTC
 241 ACTTTAGTGGCTTTCATTTAATATGGCTGTCTGGGAAGAACAGGGTTGCCTAGCCCTGTACAATGTAATTTAAACTTACA
 321 GCATTTTTACTGTGTATGATATGGTGTCCTCTGTGCCAGTTTTGTACCTTATAGAGGCAGATTGCCTCCGATCGCTGTGG
 401 TTCTTATTATCAAAATTAAGTTTACTTGTATACGGAACAACCACAAGAAATTTGATTCTGTAAAGAATCCTCTTTAGCTG
 481 TGGCCTGGCAGTATATAAATGGTGCTTTATTTAACAGAATACCTGTGGAGGAAATAAAGCACACTTGATGTAAAAATAAT
 561 TGTTTTATTTTTATTGACATGACTGATTGATTGATTGCTATTCTGTGCACTTAATTAAACTGATTGTGATGACTTTTCAT
 641 TTGTTTAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uagucucgGGAGACUCGAAGUc 5'
                  ::|:|| |||||| 
Target 5' cttatttgTTTTTGTGCTTCAg 3'
 69 - 90 126.00 -14.90
2 
miRNA  3' uaGUCUCGGGAGAC----UCGAAGUc 5'
            ::| |:||||||    ||:||:: 
Target 5' taTGGTGTCCTCTGTGCCAGTTTTGt 3'
 340 - 365 118.00 -16.82
3 
miRNA  3' uaGUCUCGGGAGACUCGAAGUc 5'
            ||| ||:||||  |||| | 
Target 5' tcCAGTGCTCTCT--GCTTGAa 3'
 95 - 114 115.00 -15.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30716846 20 COSMIC
COSN19387542 40 COSMIC
COSN30527429 42 COSMIC
COSN6189397 59 COSMIC
COSN5508193 62 COSMIC
COSN31506975 70 COSMIC
COSN5851654 70 COSMIC
COSN30111963 74 COSMIC
COSN18726862 128 COSMIC
COSN24385716 166 COSMIC
COSN30511333 187 COSMIC
COSN20096754 201 COSMIC
COSN30126746 266 COSMIC
COSN31585945 270 COSMIC
COSN30128052 332 COSMIC
COSN30728328 344 COSMIC
COSN26564527 403 COSMIC
COSN20096742 584 COSMIC
COSN23446934 587 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs757429225 1 dbSNP
rs751900335 2 dbSNP
rs763955723 3 dbSNP
rs762877050 4 dbSNP
rs1303107326 5 dbSNP
rs201356428 7 dbSNP
rs1170984009 10 dbSNP
rs1393539077 10 dbSNP
rs759027175 12 dbSNP
rs747919040 14 dbSNP
rs1421199830 15 dbSNP
rs1047405124 20 dbSNP
rs1435095233 23 dbSNP
rs776008043 24 dbSNP
rs1475316115 25 dbSNP
rs770540687 28 dbSNP
rs760230196 30 dbSNP
rs775723756 30 dbSNP
rs772901471 32 dbSNP
rs1481289519 36 dbSNP
rs377232800 37 dbSNP
rs1243069675 38 dbSNP
rs749687408 39 dbSNP
rs772430552 41 dbSNP
rs1256528446 43 dbSNP
rs373240678 44 dbSNP
rs1335942419 45 dbSNP
rs770219215 46 dbSNP
rs1226829929 47 dbSNP
rs745896985 48 dbSNP
rs746161609 48 dbSNP
rs1480917890 56 dbSNP
rs1197400401 57 dbSNP
rs1248171594 59 dbSNP
rs749064258 59 dbSNP
rs1437724228 61 dbSNP
rs1273154415 62 dbSNP
rs747071492 62 dbSNP
rs911750526 66 dbSNP
rs928482124 69 dbSNP
rs966628459 76 dbSNP
rs1166605285 77 dbSNP
rs1396230822 78 dbSNP
rs1246462973 80 dbSNP
rs539386138 80 dbSNP
rs777446822 82 dbSNP
rs1384510860 83 dbSNP
rs1022930111 85 dbSNP
rs1313721089 86 dbSNP
rs1381153869 90 dbSNP
rs974017191 92 dbSNP
rs571933941 93 dbSNP
rs554479065 94 dbSNP
rs957637366 99 dbSNP
rs1296240259 101 dbSNP
rs1338531964 103 dbSNP
rs1204037686 109 dbSNP
rs535774131 114 dbSNP
rs962846614 119 dbSNP
rs1460146470 120 dbSNP
rs1183125802 122 dbSNP
rs1262533694 124 dbSNP
rs1430313863 135 dbSNP
rs1016121677 136 dbSNP
rs1002050275 154 dbSNP
rs1372955107 160 dbSNP
rs1004291637 166 dbSNP
rs769393544 170 dbSNP
rs1178990901 173 dbSNP
rs1407923114 173 dbSNP
rs192206142 174 dbSNP
rs1355017867 176 dbSNP
rs970239950 177 dbSNP
rs1308740225 178 dbSNP
rs891326992 191 dbSNP
rs747693313 195 dbSNP
rs780616057 197 dbSNP
rs1383623580 199 dbSNP
rs1163242888 200 dbSNP
rs1321077189 201 dbSNP
rs1203276358 204 dbSNP
rs1258297096 208 dbSNP
rs1486900339 211 dbSNP
rs1203440914 212 dbSNP
rs997107575 216 dbSNP
rs1047351330 223 dbSNP
rs1202156156 223 dbSNP
rs556754974 224 dbSNP
rs1175823588 225 dbSNP
rs1470091073 226 dbSNP
rs994504512 230 dbSNP
rs1174943370 234 dbSNP
rs900054395 235 dbSNP
rs1489607833 242 dbSNP
rs1290386006 243 dbSNP
rs1038737194 246 dbSNP
rs1286609570 249 dbSNP
rs1323116035 251 dbSNP
rs1405495321 261 dbSNP
rs780131018 262 dbSNP
rs1343443306 264 dbSNP
rs1222946930 269 dbSNP
rs892792537 270 dbSNP
rs1053315610 271 dbSNP
rs530209873 273 dbSNP
rs1374010086 281 dbSNP
rs911696688 288 dbSNP
rs1237055623 299 dbSNP
rs1260235892 301 dbSNP
rs1051613636 302 dbSNP
rs1267327849 304 dbSNP
rs1403013301 310 dbSNP
rs754500703 310 dbSNP
rs1490302846 312 dbSNP
rs1178110486 317 dbSNP
rs1408350205 319 dbSNP
rs1363861288 322 dbSNP
rs945242949 328 dbSNP
rs934427488 332 dbSNP
rs1302593259 333 dbSNP
rs928463409 337 dbSNP
rs913814386 340 dbSNP
rs1045507749 342 dbSNP
rs1304903157 342 dbSNP
rs3841388 342 dbSNP
rs1363609897 343 dbSNP
rs1435545255 353 dbSNP
rs948651941 355 dbSNP
rs989845128 356 dbSNP
rs1375871428 359 dbSNP
rs915806362 363 dbSNP
rs1308754370 367 dbSNP
rs538346630 368 dbSNP
rs1400419804 370 dbSNP
rs1413355194 371 dbSNP
rs973943645 372 dbSNP
rs1359345990 375 dbSNP
rs879237901 377 dbSNP
rs371160915 378 dbSNP
rs758576699 380 dbSNP
rs908536712 382 dbSNP
rs1213127394 386 dbSNP
rs983273784 389 dbSNP
rs1489272024 390 dbSNP
rs1383375845 393 dbSNP
rs1404681352 394 dbSNP
rs955449229 397 dbSNP
rs1258541040 403 dbSNP
rs1214810922 406 dbSNP
rs752014377 406 dbSNP
rs1024388930 407 dbSNP
rs1330995859 409 dbSNP
rs1383762257 411 dbSNP
rs1029847559 414 dbSNP
rs35833610 416 dbSNP
rs996992972 416 dbSNP
rs1215669389 422 dbSNP
rs1306148513 423 dbSNP
rs866503877 423 dbSNP
rs1204240601 424 dbSNP
rs187721106 428 dbSNP
rs767751640 431 dbSNP
rs1461484559 432 dbSNP
rs561466742 433 dbSNP
rs995519038 434 dbSNP
rs898816087 436 dbSNP
rs1011156445 437 dbSNP
rs541132321 439 dbSNP
rs1169690116 443 dbSNP
rs1407191580 444 dbSNP
rs527712653 447 dbSNP
rs1453310768 453 dbSNP
rs1471087233 460 dbSNP
rs1334882147 469 dbSNP
rs750801604 471 dbSNP
rs1431509939 474 dbSNP
rs1272478401 483 dbSNP
rs1360449673 484 dbSNP
rs1218477335 498 dbSNP
rs566749020 500 dbSNP
rs1326023401 511 dbSNP
rs1205211397 515 dbSNP
rs762965552 517 dbSNP
rs1441392576 519 dbSNP
rs1215849736 522 dbSNP
rs1161789924 523 dbSNP
rs1468749723 524 dbSNP
rs1192782498 525 dbSNP
rs1429744063 531 dbSNP
rs1481271168 540 dbSNP
rs890219635 542 dbSNP
rs1401736589 546 dbSNP
rs1051547677 548 dbSNP
rs1320363617 550 dbSNP
rs1344006923 551 dbSNP
rs1429144776 557 dbSNP
rs1399945486 560 dbSNP
rs1176199887 564 dbSNP
rs945191784 568 dbSNP
rs1347807649 574 dbSNP
rs765484115 578 dbSNP
rs201913510 587 dbSNP
rs906922430 588 dbSNP
rs1343852012 589 dbSNP
rs1045561133 590 dbSNP
rs1223914764 591 dbSNP
rs1285768228 592 dbSNP
rs1259250882 594 dbSNP
rs201709566 594 dbSNP
rs1269447811 598 dbSNP
rs16348 598 dbSNP
rs3217620 598 dbSNP
rs528239073 598 dbSNP
rs565664995 598 dbSNP
rs1490792526 600 dbSNP
rs1196436623 606 dbSNP
rs1377350411 613 dbSNP
rs1470627170 614 dbSNP
rs1405888610 619 dbSNP
rs747705896 619 dbSNP
rs948580263 624 dbSNP
rs1053696917 625 dbSNP
rs762005879 626 dbSNP
rs1164831283 627 dbSNP
rs1465043800 627 dbSNP
rs1249711653 628 dbSNP
rs936598865 632 dbSNP
rs547710189 633 dbSNP
rs925954298 634 dbSNP
rs529132736 635 dbSNP
rs1280889102 637 dbSNP
rs1322767314 638 dbSNP
rs980514074 639 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla 0.682 5.1e-3 0.615 1.3e-2 13 Click to see details
GSE42095 Differentiated embryonic stem cells 0.486 9.4e-3 0.270 1.1e-1 23 Click to see details
GSE21687 Ependynoma primary tumors 0.199 5.7e-2 0.071 2.9e-1 64 Click to see details
GSE19350 CNS germ cell tumors 0.38 1.1e-1 0.538 3.6e-2 12 Click to see details
GSE19783 ER+ ER+ breast cancer -0.244 1.5e-1 -0.346 6.8e-2 20 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.149 2.4e-1 -0.045 4.2e-1 25 Click to see details
GSE38226 Liver fibrosis 0.154 2.5e-1 0.131 2.9e-1 21 Click to see details
GSE32688 Pancreatic cancer -0.1 2.9e-1 -0.145 2.1e-1 32 Click to see details
GSE19783 ER- ER- breast cancer 0.06 3.0e-1 0.148 9.7e-2 79 Click to see details
GSE26953 Aortic valvular endothelial cells -0.079 3.6e-1 -0.168 2.2e-1 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.04 4.3e-1 -0.630 1.5e-3 20 Click to see details
GSE17498 Multiple myeloma 0.015 4.6e-1 0.006 4.9e-1 40 Click to see details
GSE28544 Breast cancer 0.019 4.6e-1 0.072 3.7e-1 24 Click to see details
GSE19536 Breast cancer 0.007 4.7e-1 0.049 3.1e-1 100 Click to see details
GSE19536 Breast cancer 0.007 4.7e-1 0.049 3.1e-1 100 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
ESCA -0.738 0 -0.718 0.01 11 Click to see details
BLCA -0.468 0.03 -0.455 0.03 18 Click to see details
KICH 0.382 0.03 0.332 0.05 25 Click to see details
THCA 0.232 0.04 0.152 0.13 59 Click to see details
COAD -0.504 0.1 -0.405 0.16 8 Click to see details
STAD -0.19 0.15 -0.268 0.07 32 Click to see details
KIRC -0.121 0.16 -0.129 0.15 68 Click to see details
CESC -0.861 0.17 -1.000 0.5 3 Click to see details
LUAD -0.215 0.25 -0.147 0.32 12 Click to see details
KIRP 0.099 0.29 0.184 0.16 32 Click to see details
BRCA 0.055 0.31 0.003 0.49 84 Click to see details
UCEC -0.087 0.36 -0.111 0.33 19 Click to see details
PAAD -0.244 0.38 0.200 0.4 4 Click to see details
PCPG -0.253 0.42 -0.500 0.33 3 Click to see details
HNSC -0.027 0.43 -0.008 0.48 42 Click to see details
LIHC 0.023 0.44 -0.015 0.46 49 Click to see details
CHOL -0.058 0.44 0.150 0.35 9 Click to see details
LUSC 0.02 0.45 -0.126 0.23 38 Click to see details
PRAD 0.016 0.46 0.005 0.49 50 Click to see details
PRAD 0.016 0.46 0.005 0.49 50 Click to see details
PRAD 0.016 0.46 0.005 0.49 50 Click to see details
113 hsa-miR-127-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT380928 ZNF264 zinc finger protein 264 2 2
MIRT439324 USP34 ubiquitin specific peptidase 34 1 1
MIRT439333 USP22 ubiquitin specific peptidase 22 1 1
MIRT439379 TTC37 tetratricopeptide repeat domain 37 1 1
MIRT439445 TMEM116 transmembrane protein 116 1 1
MIRT439498 SYNJ2 synaptojanin 2 1 1
MIRT439525 STBD1 starch binding domain 1 1 1
MIRT439562 SORL1 sortilin related receptor 1 1 1
MIRT439660 SF3B1 splicing factor 3b subunit 1 1 1
MIRT439749 ROGDI rogdi homolog 1 1
MIRT439836 RAB3B RAB3B, member RAS oncogene family 1 1
MIRT439923 PPL periplakin 1 1
MIRT439963 PKD1 polycystin 1, transient receptor potential channel interacting 1 1
MIRT439985 PHKG2 phosphorylase kinase catalytic subunit gamma 2 1 1
MIRT440029 PCLO piccolo presynaptic cytomatrix protein 1 1
MIRT440179 MTRNR2L8 MT-RNR2-like 8 1 1
MIRT440183 MTRNR2L4 MT-RNR2-like 4 1 1
MIRT440184 MTRNR2L6 MT-RNR2-like 6 1 1
MIRT440194 MTRNR2L1 MT-RNR2-like 1 1 1
MIRT440269 MBP myelin basic protein 1 1
MIRT440323 LIN7C lin-7 homolog C, crumbs cell polarity complex component 1 1
MIRT440331 LGALS8 galectin 8 1 1
MIRT440355 KLHL29 kelch like family member 29 1 1
MIRT440397 KDM6B lysine demethylase 6B 1 1
MIRT440411 KAT2B lysine acetyltransferase 2B 1 1
MIRT440424 ITCH itchy E3 ubiquitin protein ligase 1 1
MIRT440651 FBXO7 F-box protein 7 1 1
MIRT440773 DST dystonin 1 1
MIRT440824 DGKD diacylglycerol kinase delta 1 1
MIRT440914 COPA coatomer protein complex subunit alpha 1 1
MIRT441118 BBS4 Bardet-Biedl syndrome 4 1 1
MIRT441153 ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 1 1
MIRT441193 ARID1A AT-rich interaction domain 1A 1 1
MIRT441260 ADM adrenomedullin 1 1
MIRT441282 ACTB actin beta 1 1
MIRT441306 ABHD2 abhydrolase domain containing 2 1 1
MIRT441860 TEX35 testis expressed 35 2 2
MIRT442190 CCDC132 VPS50, EARP/GARPII complex subunit 2 2
MIRT442886 RHCG Rh family C glycoprotein 2 2
MIRT444158 ZNF701 zinc finger protein 701 2 2
MIRT444506 ZNF525 zinc finger protein 525 2 2
MIRT444770 NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 2 2
MIRT445830 SRSF11 serine and arginine rich splicing factor 11 2 2
MIRT445850 LRRC1 leucine rich repeat containing 1 2 2
MIRT445863 ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2 2
MIRT446161 C8A complement C8 alpha chain 2 2
MIRT447117 SLFN5 schlafen family member 5 2 2
MIRT447990 CDX1 caudal type homeobox 1 2 2
MIRT449032 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 2 2
MIRT449295 SMIM19 small integral membrane protein 19 2 2
MIRT449541 PCDH9 protocadherin 9 2 2
MIRT449579 ZNF510 zinc finger protein 510 2 2
MIRT450062 SYT9 synaptotagmin 9 2 2
MIRT450437 CAPZA1 capping actin protein of muscle Z-line alpha subunit 1 2 2
MIRT450449 ZDHHC2 zinc finger DHHC-type containing 2 2 2
MIRT450695 RORA RAR related orphan receptor A 2 2
MIRT453654 RAB6C RAB6C, member RAS oncogene family 2 2
MIRT463771 YOD1 YOD1 deubiquitinase 2 2
MIRT468425 SETD1B SET domain containing 1B 2 2
MIRT468843 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT475594 HMGB2 high mobility group box 2 4 4
MIRT478284 DDX19A DEAD-box helicase 19A 2 2
MIRT487594 NKD2 naked cuticle homolog 2 2 4
MIRT493440 KANSL1 KAT8 regulatory NSL complex subunit 1 2 6
MIRT496169 RPL35A ribosomal protein L35a 2 4
MIRT497566 CCR6 C-C motif chemokine receptor 6 2 2
MIRT497917 BTG1 BTG anti-proliferation factor 1 2 2
MIRT498331 PRELID2 PRELI domain containing 2 2 2
MIRT498369 KLHL11 kelch like family member 11 2 2
MIRT498856 LITAF lipopolysaccharide induced TNF factor 2 2
MIRT505640 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT506128 PLRG1 pleiotropic regulator 1 2 4
MIRT512242 ARPP19 cAMP regulated phosphoprotein 19 2 4
MIRT512489 ARID2 AT-rich interaction domain 2 2 2
MIRT525251 RNF213 ring finger protein 213 2 2
MIRT530197 ALX1 ALX homeobox 1 2 4
MIRT530551 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT534048 STC2 stanniocalcin 2 2 2
MIRT537508 FAM105A family with sequence similarity 105 member A 2 2
MIRT543005 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT543814 SNX10 sorting nexin 10 2 2
MIRT549303 ARID5B AT-rich interaction domain 5B 2 2
MIRT549407 ADIPOR2 adiponectin receptor 2 2 4
MIRT550547 ARSK arylsulfatase family member K 2 2
MIRT554319 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT554515 RUFY2 RUN and FYVE domain containing 2 2 2
MIRT559603 AMOT angiomotin 2 2
MIRT564844 ZBED3 zinc finger BED-type containing 3 2 2
MIRT566125 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT567484 FOXK1 forkhead box K1 2 2
MIRT576521 Txlna taxilin alpha 2 2
MIRT633635 CASC5 kinetochore scaffold 1 2 2
MIRT639325 C9orf41 carnosine N-methyltransferase 1 2 2
MIRT643174 MDM2 MDM2 proto-oncogene 2 2
MIRT651214 ZNF225 zinc finger protein 225 2 2
MIRT653039 STRIP2 striatin interacting protein 2 2 2
MIRT653042 STOX2 storkhead box 2 2 2
MIRT658769 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT666728 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT681223 DUSP19 dual specificity phosphatase 19 2 2
MIRT685562 SRD5A3 steroid 5 alpha-reductase 3 2 2
MIRT687434 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT688439 DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 2 2
MIRT692707 MEAF6 MYST/Esa1 associated factor 6 2 2
MIRT700552 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT704955 CBX2 chromobox 2 2 2
MIRT714524 ALKBH3 alkB homolog 3, alpha-ketoglutaratedependent dioxygenase 2 2
MIRT716225 DGKI diacylglycerol kinase iota 2 2
MIRT717953 MIA3 MIA family member 3, ER export factor 2 2
MIRT719902 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT732044 BLVRB biliverdin reductase B 3 1
MIRT733622 SNX5 sorting nexin 5 3 0
MIRT737210 CXCR4 C-X-C motif chemokine receptor 4 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-127 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR rat breast 17700064 2007 down-regulated
miR-127 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) NULL NULL Microarray T24 human bladder cancer cells 16766263 2006 up-regulated
miR-127 17beta-estradiol (E2) approved 5757 Microarray rat breast 17700064 2007 down-regulated
miR-127-5p Glucose NULL 5793 Microarray endothelial cells 24394957 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-127 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-mir-127 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-miR-127-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-127-5p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM11)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-127-5p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-127-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-127-5p Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR200)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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