miRTarBase - #MIRT439333


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pre-miRNA Information
pre-miRNA hsa-mir-127   
Genomic Coordinates chr14: 100882979 - 100883075
Description Homo sapiens miR-127 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-127-5p
Sequence 23| CUGAAGCUCAGAGGGCUCUGAU |44
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM9722115 13 COSMIC
COSM7115045 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs867796380 11 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol USP22   
Synonyms USP3L
Description ubiquitin specific peptidase 22
Transcript NM_015276   
Expression
Putative miRNA Targets on USP22
3'UTR of USP22
(miRNA target sites are highlighted)		 
>USP22|NM_015276|3'UTR
   1 CCTTATCTGCAGCTGGTCAGAAAAACAAAGGCAATGCATTGGCAAGCCTCACAAAGTGATCCTCCCTGGCCCCCCCCTCC
  81 CCCAAGTCTCCCGCCGCCTCCCCGGCCTGGTGACACCACCTCCCATGCAGATGTGGCCCCTCTGCACCTGGGACCCATCG
 161 GGTCGGGATGGACCACACGGACGGGGAGGCTCCTGGAGCTGCTTTGAAGATGGATGAGATGAGGGGTGTGCTCTGGGTGG
 241 GAGGAGCAGCGTACACCCGTCACCAGAACATCTCTTGTGTCATGACATGGGGGTGCAACGGGGGCCTCACAGCACAGAGT
 321 GACCGCTGCCTGGCGTTCCCCAGCACTCGGTGTGGAAAGGCCCCTACCTGCTGTAAGATTATGGGTCCATGAAAGCAGTA
 401 AGCTGGACACAGAGGTGTAGTGTGCGGGACAGAGGGCCTTGCAGATGCCTTTCTGTTGGTGTTTTAGTGTTAAAATACGG
 481 AGAGTATGGAACTCTTCACCTCCATTTTCTCAGCGGCTGTGAAGCAGCCTCCTAGCTTCGGAAGTACGGACACTACGTCG
 561 CGTTTTCAAGCGTGTCTGTTCTGCAGGTAACAGCATCAAGCTGCACGTGGAAGCATCTCGCGGTTTTCTAGAAACAGGCA
 641 TTTTCTTATCCCTCTCCCGCTCCTTTTTCCACAAAGGTGAATTTCATAAATGTAATACTAGTAAAGTGAATGAATTACTG
 721 AGTTTATACAGAAATTTAGGTAACTTCTCCTTTAGTCTCAAGAGCGAGTCTTGCTTTTTAATGGGTGCCGTTTATGTTGC
 801 TGCCCGCCCTGTGTGCCTGGCTCCTCTGGGTGCCTTGGTGTCTGCTGGTGGCTGGCAGTGGGCGCAGCGGAGGAGAGTTG
 881 TGCTGCAGCTCATACGGTGTGTCTGTCATCTCAGTCTGGAGTAAATGCAGTGTCTGCCGGTGTCTGATGGGTTCTGTCCC
 961 TCGTATTTTCTTTGCCTTCTATCCCATTGCCTGGCTACCGCTGCCTGGCAGCCAAGGGTGTTGGTCGCGAAGCTGGAGTG
1041 GCCTCTGGTGGAGCCTGCATCTTGTCTCGTCTGCCTCTGCTTTACATTTGGTGTACTTTCGGGCGTGGTGGCAGTAAAAT
1121 GACACCGTGATTGAGCTTGTCAGCAGAGCTGAAAGAGAAAGTAGAAGGATGTGCATTGTTTCTTGTAAGATATCTTGCAT
1201 GTATCTGTGTATTCAAATTCAAACAGAGATGGTTTGTCCATTTGTCCACTGAGAAATTAGAAACTAGGGACAAGGGGGAG
1281 GAAAAGTACTGAAATACAGTTTATGAAGCAAGTGTGTCTCGGGCTGTGCTTGTCCCAGGAGCCCCAGCAGCATCTGAACT
1361 GAGGCTTCTTCAGTCCTGCAGGAACAGGATCATCTGTCTCAGCGGTGGGCAGATGTTTTCATAGACAGCCAGGGAGTAAA
1441 CACTGTTGGCTCTGTGGGCTGTATGGTCTCTGCCATAAATAGTACAGAGATGTGGCTGTGTCTAGTACAACTTTTAGACA
1521 CAGAAATCTGAATGACATATATTGTTCTGTGTCAAGAAACTTAGATTTTTTTTTTAACTATTTAAAAACGTGAAACCTAT
1601 TCTTAGCTCACAGGCCATGGAGAAGCTGGTGGGGACCAGACCCAGCTCCTTAGCTGGCTGGGCTGGGGAGGGGGTAGTGA
1681 CAGTGGCAGCTGCTACTCACTGCTCAGTGTGGAAAACACAGGACTTGGCAATCACAGCCCGCAGAACCATCATGTGTGGC
1761 AGAAGCCTGAGGGATGCGGTTTCTTGCCCACGTGCTCTGTTCATTTTCTGTTGTTTTTCTGCACTTAAAGAATTCACATG
1841 GAAGCATGTTTTATAAAATGAATTACCAGAGAAACAGAGATGGGCCGAGATTTTCAGAAATGGTCCCATGTGACCAAGTT
1921 CTGCTGTTTGGGTGACAGTGCTTTGAAGATCTCCTTTGAGGATGTGCAGTCTTTTTTTTTTTTTTTTTGAGATGGAGTTT
2001 GTTGCCCAGGCTGGAGTGAGTGGCACAGTCTCGGCTCACTGCAACCTCCACCTCCTGGGTTCAAGCAGTTCTCGTGCCGC
2081 AGCCTCCCAAGTAGCTGGGACTACAGGCATGCACCACCACGCCAGGCTAATTTTTGTATTTTTAGTAGAGATGGGGTTTC
2161 ACCATGTCTCAAACTCCTGACCTCAGGCGATCCACCCACCTCAGCGTCCCAAAGTGCTGGGATTATAGGCGTGAGCCACC
2241 GCACCTGGCCTATGAGTGGTCTTTTAATTAGGAACAAATCTAATGGAAAGGAGAGTTGACTGAAGTTGGCCCACAGGATT
2321 GTGAGCTGGGCAGTGCCTTCATGAAGGCTTGCCACCTTGGGACGCCCCAGTTTACTGGGGTGTCTTGCGGAGTGCAGAAG
2401 GCTTTCTGGCAGCTGCCTGGGTTTGGCCAGACCCTGCCTCCCCTCCCGCCGGCCAACCCCTAGTCCCCTTCCTGTCTCCA
2481 CTTGCATTCAGGGGTGGCTGCTGTTCTGAGAACATTAGAACTGGGAAGAGAGATGGAGTCACATGGATTTTTGGTGGGCA
2561 TTATTCTAAACTTTCGTATCCAAGTTAGTCCCCCTTATTCCACTGTGGCATTGCCGTTCTAAGCAGTTACCTGATGCCTG
2641 CTGCTGAAGAGCTGCTCACAGGAGGCGGCGGCGGCCCTGGCACTGCCCCTTGCATTAGGTCTTGTGTTTGATGTGTTCTT
2721 GTGAATTTACTTTGTCAGAACAAAATATTTACGCGTTGGGTTCAGGAATTTCTTTTAGCTCCCCATCTGGCTGTGAAATT
2801 CAGGAAACCTCCCGTTGCCTAGTAATCACCCCATGTAGGTGTACATTGTGACAAAGTGCATCTGACCACTAAGGGGCCCC
2881 CTTGGTGACCCCAGCACATTCACAGCAGTGTTAAAATGGCCTGCATTTTGGAGATGCTGGCTGGCCTTTCAGTGCCTCCC
2961 AGGAAGACACATGGCCTTTCCCTCTTCAGATGCCTGAAGGGAGTGCTTTGAGGCAGGTGATGTGCTGGGAGTGTGGGCGG
3041 CCTCCCTCTGGCCCCGGGGCCCTCTGTGGACCTTGGCTCCCTCCGTGGACCTGGGCTTCGTGGTGAGCACTGCAGCCTCC
3121 CTGGGCATTCCCTCCAGCGCCAGCACCACTGCAACATATAGACCTGAGTGCTATTGTATTTTGGCTTGGTGTGTATGCTC
3201 TTCATTGTGTAAAATTGCTGTTCTTTTGACAATTTAAGTGATTGTTTTGTTTACTGTAAGTTTGAAAATAAAAATGAAGA
3281 AAAAAATTCCAATGACTGTGCTGTGGTTGGAGACTTTATTTACCAAGATGTTTACTCTTCCTTTCCCCTTCCATTTTGAG
3361 GAGCTGTGTCACTCCTCCTCCCCCCCAGTGCTTTGTAGTCTCTCCTATGTCATAATAAAGCTACATTTTCTCTGAGAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uagUC-UCGGGAGACUCGAAGUc 5'
             || ||||: || ||||||: 
Target 5' tgaAGCAGCCTCCT-AGCTTCGg 3'
 520 - 541 146.00 -20.40
2 
miRNA  3' uaGUC-UCG-GGA---GAC-UCGAAGuc 5'
            ||| ||| :||   ||| :|||||  
Target 5' ccCAGCAGCATCTGAACTGAGGCTTCtt 3'
 1343 - 1370 124.00 -15.20
3 
miRNA  3' uaGUCUCGGGAGACUCGAAGUc 5'
            |: :| |  |||:|||||: 
Target 5' tcCGTGGAC--CTGGGCTTCGt 3'
 3082 - 3101 124.00 -14.60
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN6655071 30 COSMIC
COSN30515331 39 COSMIC
COSN31612619 69 COSMIC
COSN30514790 88 COSMIC
COSN8866137 93 COSMIC
COSN30462955 100 COSMIC
COSN30137906 124 COSMIC
COSN17207344 330 COSMIC
COSN8833123 412 COSMIC
COSN32058046 416 COSMIC
COSN22603161 592 COSMIC
COSN8833122 872 COSMIC
COSN1194101 985 COSMIC
COSN32061698 993 COSMIC
COSN28285068 1199 COSMIC
COSN23344474 1501 COSMIC
COSN29751022 1526 COSMIC
COSN19227450 1541 COSMIC
COSN28468146 1565 COSMIC
COSN21351169 2432 COSMIC
COSN31779161 2575 COSMIC
COSN1194100 3106 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs749488956 6 dbSNP
rs1003342799 7 dbSNP
rs902331382 18 dbSNP
rs1416382664 28 dbSNP
rs561080513 30 dbSNP
rs1172458175 31 dbSNP
rs1374061733 35 dbSNP
rs1417055819 36 dbSNP
rs371246870 40 dbSNP
rs1262965446 43 dbSNP
rs1229221919 47 dbSNP
rs745831391 48 dbSNP
rs145360694 50 dbSNP
rs1329025938 58 dbSNP
rs1325876917 61 dbSNP
rs1239718005 62 dbSNP
rs1279569186 64 dbSNP
rs78002521 66 dbSNP
rs752517739 67 dbSNP
rs1387716120 69 dbSNP
rs978995143 70 dbSNP
rs893832398 71 dbSNP
rs3214918 72 dbSNP
rs78523442 72 dbSNP
rs1393860745 74 dbSNP
rs556823378 75 dbSNP
rs1461192018 76 dbSNP
rs965433916 76 dbSNP
rs1381046738 77 dbSNP
rs11430423 78 dbSNP
rs1302044562 78 dbSNP
rs377713052 78 dbSNP
rs397945787 78 dbSNP
rs372441582 79 dbSNP
rs879473005 81 dbSNP
rs1477137815 84 dbSNP
rs4985957 87 dbSNP
rs4985956 93 dbSNP
rs71360622 94 dbSNP
rs951206979 95 dbSNP
rs1027241265 96 dbSNP
rs1419287301 98 dbSNP
rs1427147862 103 dbSNP
rs534383259 104 dbSNP
rs1355972440 120 dbSNP
rs1214424802 122 dbSNP
rs1324635495 138 dbSNP
rs1488967592 140 dbSNP
rs974072451 142 dbSNP
rs567358907 144 dbSNP
rs909561614 147 dbSNP
rs1361151909 148 dbSNP
rs990431223 157 dbSNP
rs796787006 159 dbSNP
rs1342355731 164 dbSNP
rs959000620 165 dbSNP
rs1034747749 168 dbSNP
rs1276315874 169 dbSNP
rs1003206690 177 dbSNP
rs966524259 178 dbSNP
rs1242093998 179 dbSNP
rs1276820898 181 dbSNP
rs555375763 182 dbSNP
rs1188724222 183 dbSNP
rs1402351601 189 dbSNP
rs1020777067 192 dbSNP
rs1477949070 196 dbSNP
rs11541314 199 dbSNP
rs1415070306 205 dbSNP
rs893706740 208 dbSNP
rs1333529082 210 dbSNP
rs1323624005 216 dbSNP
rs1344598838 220 dbSNP
rs1290417125 221 dbSNP
rs1412844095 225 dbSNP
rs577792219 227 dbSNP
rs1039475439 229 dbSNP
rs1291708572 232 dbSNP
rs569694991 237 dbSNP
rs796500156 239 dbSNP
rs1283641354 244 dbSNP
rs1315660523 247 dbSNP
rs72838200 251 dbSNP
rs1243074229 258 dbSNP
rs1051854429 259 dbSNP
rs1478734438 263 dbSNP
rs780497278 265 dbSNP
rs1242637384 267 dbSNP
rs1163402616 269 dbSNP
rs1186218763 270 dbSNP
rs1398895276 271 dbSNP
rs1161139743 272 dbSNP
rs1361052924 277 dbSNP
rs538639141 277 dbSNP
rs1357673098 282 dbSNP
rs1415552887 285 dbSNP
rs1371207969 286 dbSNP
rs1264479750 287 dbSNP
rs1280267382 293 dbSNP
rs1226013328 294 dbSNP
rs1285628834 294 dbSNP
rs1347766563 298 dbSNP
rs566729905 299 dbSNP
rs1316950565 300 dbSNP
rs1256502271 304 dbSNP
rs1282908198 308 dbSNP
rs965404787 309 dbSNP
rs1187743488 314 dbSNP
rs1341610031 317 dbSNP
rs1037853253 318 dbSNP
rs1178409070 322 dbSNP
rs371959256 324 dbSNP
rs1284199819 325 dbSNP
rs916174953 325 dbSNP
rs1230943165 333 dbSNP
rs991675845 334 dbSNP
rs376258836 335 dbSNP
rs1335070231 338 dbSNP
rs1352953554 340 dbSNP
rs959034085 341 dbSNP
rs114358401 348 dbSNP
rs1026797099 349 dbSNP
rs1370999928 357 dbSNP
rs995770816 359 dbSNP
rs1306105299 363 dbSNP
rs1200708363 366 dbSNP
rs1348990192 366 dbSNP
rs981858727 368 dbSNP
rs546929766 370 dbSNP
rs149896946 373 dbSNP
rs1021231315 378 dbSNP
rs1010727528 379 dbSNP
rs139080419 381 dbSNP
rs1030630023 382 dbSNP
rs1017551901 384 dbSNP
rs1007445355 389 dbSNP
rs529822009 391 dbSNP
rs1411866187 397 dbSNP
rs1332134436 400 dbSNP
rs903617172 403 dbSNP
rs1286782882 405 dbSNP
rs1439369218 408 dbSNP
rs191915934 411 dbSNP
rs1332155613 415 dbSNP
rs147386796 416 dbSNP
rs1268781976 418 dbSNP
rs561060298 425 dbSNP
rs993622692 426 dbSNP
rs897895233 431 dbSNP
rs1258166106 436 dbSNP
rs1038161346 438 dbSNP
rs942228093 441 dbSNP
rs1235988208 443 dbSNP
rs1467603239 445 dbSNP
rs1200913302 447 dbSNP
rs900074503 449 dbSNP
rs894594311 451 dbSNP
rs1254871194 454 dbSNP
rs186332555 455 dbSNP
rs944280043 455 dbSNP
rs1476521951 458 dbSNP
rs1171593134 459 dbSNP
rs530793250 463 dbSNP
rs930059739 464 dbSNP
rs182117610 465 dbSNP
rs981724279 466 dbSNP
rs1284805513 476 dbSNP
rs1382089117 476 dbSNP
rs945149877 478 dbSNP
rs554975168 479 dbSNP
rs989611986 482 dbSNP
rs957902032 483 dbSNP
rs544966574 484 dbSNP
rs986081227 499 dbSNP
rs577881576 504 dbSNP
rs556265598 506 dbSNP
rs1266699355 508 dbSNP
rs1030599194 514 dbSNP
rs1259426381 515 dbSNP
rs993523820 529 dbSNP
rs897794324 539 dbSNP
rs1415887220 540 dbSNP
rs903588912 547 dbSNP
rs1022496506 548 dbSNP
rs1011742729 550 dbSNP
rs1312684336 556 dbSNP
rs372702953 557 dbSNP
rs1006683972 559 dbSNP
rs1312641778 561 dbSNP
rs144190356 562 dbSNP
rs555478014 570 dbSNP
rs1055885825 572 dbSNP
rs1219856104 574 dbSNP
rs938959136 576 dbSNP
rs907453111 578 dbSNP
rs1279254241 583 dbSNP
rs891407559 587 dbSNP
rs1183767977 594 dbSNP
rs1041924240 595 dbSNP
rs1256986350 598 dbSNP
rs1047082540 599 dbSNP
rs1179719941 606 dbSNP
rs930002406 607 dbSNP
rs1453776337 610 dbSNP
rs1293145277 612 dbSNP
rs537187869 616 dbSNP
rs368419591 619 dbSNP
rs752141922 620 dbSNP
rs189735657 621 dbSNP
rs57426028 622 dbSNP
rs916383961 623 dbSNP
rs1311697764 626 dbSNP
rs1390367849 636 dbSNP
rs991969561 639 dbSNP
rs571929762 640 dbSNP
rs936413127 650 dbSNP
rs910428345 653 dbSNP
rs968157179 656 dbSNP
rs985945003 657 dbSNP
rs546843050 658 dbSNP
rs11541317 659 dbSNP
rs1381366289 669 dbSNP
rs185316757 670 dbSNP
rs1194224744 679 dbSNP
rs1240034312 680 dbSNP
rs1193511184 693 dbSNP
rs1434029487 693 dbSNP
rs1030270711 695 dbSNP
rs1393693053 697 dbSNP
rs1455886356 698 dbSNP
rs1351547977 700 dbSNP
rs972349713 717 dbSNP
rs757746699 718 dbSNP
rs962074964 725 dbSNP
rs1016669125 735 dbSNP
rs562888821 737 dbSNP
rs891377866 741 dbSNP
rs958763617 742 dbSNP
rs1424047308 747 dbSNP
rs1368665608 752 dbSNP
rs567549273 753 dbSNP
rs1003009348 759 dbSNP
rs1189774156 761 dbSNP
rs994434206 762 dbSNP
rs898459306 763 dbSNP
rs549062794 765 dbSNP
rs1270203404 766 dbSNP
rs1216570712 774 dbSNP
rs1038383201 776 dbSNP
rs766358346 785 dbSNP
rs181250829 789 dbSNP
rs1489747323 790 dbSNP
rs563305236 797 dbSNP
rs1192143279 800 dbSNP
rs1261399060 803 dbSNP
rs1009135575 805 dbSNP
rs191527392 805 dbSNP
rs778343475 808 dbSNP
rs750601908 814 dbSNP
rs1056211513 817 dbSNP
rs767607717 820 dbSNP
rs1392278885 822 dbSNP
rs1311754314 823 dbSNP
rs1293912751 824 dbSNP
rs1299545696 829 dbSNP
rs537857389 830 dbSNP
rs1380779264 834 dbSNP
rs892167164 838 dbSNP
rs1053862631 842 dbSNP
rs1318844502 842 dbSNP
rs936459926 846 dbSNP
rs1347225449 854 dbSNP
rs978373589 855 dbSNP
rs910314993 863 dbSNP
rs545746086 864 dbSNP
rs1196264755 865 dbSNP
rs914868132 868 dbSNP
rs559616665 869 dbSNP
rs1186607887 870 dbSNP
rs1299436532 874 dbSNP
rs540993141 875 dbSNP
rs1018740556 876 dbSNP
rs1165350096 879 dbSNP
rs573875812 888 dbSNP
rs1453860548 891 dbSNP
rs923064080 895 dbSNP
rs878945367 896 dbSNP
rs1417686511 907 dbSNP
rs774586623 908 dbSNP
rs1299794677 910 dbSNP
rs1341438348 913 dbSNP
rs140302465 919 dbSNP
rs1414333534 927 dbSNP
rs1291539554 930 dbSNP
rs561902096 931 dbSNP
rs1228931846 936 dbSNP
rs1284233053 938 dbSNP
rs116480695 939 dbSNP
rs77996038 946 dbSNP
rs147209042 950 dbSNP
rs1488422366 951 dbSNP
rs1209650297 958 dbSNP
rs763312346 959 dbSNP
rs1473519350 962 dbSNP
rs539432642 963 dbSNP
rs1038756342 965 dbSNP
rs1034415705 973 dbSNP
rs1437745449 976 dbSNP
rs1160243643 990 dbSNP
rs958600002 998 dbSNP
rs1434368768 999 dbSNP
rs199700229 1000 dbSNP
rs150943894 1002 dbSNP
rs200964759 1002 dbSNP
rs756068042 1002 dbSNP
rs1448917560 1003 dbSNP
rs1279025921 1010 dbSNP
rs186679222 1011 dbSNP
rs1242873247 1016 dbSNP
rs1020865023 1017 dbSNP
rs576837023 1018 dbSNP
rs1310478883 1027 dbSNP
rs1232516745 1028 dbSNP
rs1010527988 1029 dbSNP
rs1276131609 1032 dbSNP
rs1443774800 1033 dbSNP
rs893362794 1035 dbSNP
rs535054984 1041 dbSNP
rs1263476327 1045 dbSNP
rs1217802969 1054 dbSNP
rs1000550138 1060 dbSNP
rs1061971 1065 dbSNP
rs567512427 1068 dbSNP
rs1050179757 1069 dbSNP
rs1427603813 1079 dbSNP
rs537654009 1079 dbSNP
rs1415184209 1086 dbSNP
rs1328284146 1091 dbSNP
rs1398144208 1096 dbSNP
rs115106789 1100 dbSNP
rs1449694718 1100 dbSNP
rs915191536 1101 dbSNP
rs923167784 1104 dbSNP
rs148027316 1105 dbSNP
rs1300599307 1111 dbSNP
rs940647534 1113 dbSNP
rs540548770 1126 dbSNP
rs911564286 1127 dbSNP
rs987187006 1133 dbSNP
rs1315570761 1141 dbSNP
rs1199956942 1142 dbSNP
rs1238778707 1159 dbSNP
rs1467970378 1161 dbSNP
rs1196484329 1162 dbSNP
rs984701918 1162 dbSNP
rs750163650 1165 dbSNP
rs950463209 1175 dbSNP
rs1167518744 1176 dbSNP
rs1421719571 1190 dbSNP
rs1026207245 1192 dbSNP
rs1464450008 1193 dbSNP
rs958701483 1193 dbSNP
rs1426390331 1199 dbSNP
rs1385530072 1200 dbSNP
rs1171794876 1202 dbSNP
rs1331998410 1202 dbSNP
rs373954438 1203 dbSNP
rs963274699 1206 dbSNP
rs1017219307 1207 dbSNP
rs1012198756 1209 dbSNP
rs1254125905 1216 dbSNP
rs895110544 1218 dbSNP
rs1291805594 1223 dbSNP
rs981527640 1228 dbSNP
rs1452009216 1229 dbSNP
rs113636900 1230 dbSNP
rs577969288 1230 dbSNP
rs971453815 1234 dbSNP
rs551455657 1239 dbSNP
rs73301793 1244 dbSNP
rs902620873 1248 dbSNP
rs1197776235 1249 dbSNP
rs1042600914 1250 dbSNP
rs1392050394 1252 dbSNP
rs1269699373 1255 dbSNP
rs1400548040 1256 dbSNP
rs3612 1260 dbSNP
rs893713002 1267 dbSNP
rs778557855 1270 dbSNP
rs547657995 1279 dbSNP
rs529212279 1283 dbSNP
rs1339327020 1284 dbSNP
rs1241948616 1297 dbSNP
rs957535963 1297 dbSNP
rs754739108 1298 dbSNP
rs753740378 1299 dbSNP
rs555131762 1302 dbSNP
rs1285934070 1303 dbSNP
rs1038932014 1312 dbSNP
rs11541315 1315 dbSNP
rs1283539440 1316 dbSNP
rs779986466 1320 dbSNP
rs1309886202 1321 dbSNP
rs1257036213 1329 dbSNP
rs1422183786 1331 dbSNP
rs943277120 1342 dbSNP
rs1369611442 1350 dbSNP
rs1383063132 1352 dbSNP
rs375357743 1360 dbSNP
rs1157243474 1364 dbSNP
rs1362790009 1367 dbSNP
rs182025734 1370 dbSNP
rs1007112929 1374 dbSNP
rs1298477198 1388 dbSNP
rs888816770 1389 dbSNP
rs1393851314 1391 dbSNP
rs1335617508 1392 dbSNP
rs911534481 1396 dbSNP
rs200572625 1398 dbSNP
rs929026976 1398 dbSNP
rs1299132222 1400 dbSNP
rs543662219 1403 dbSNP
rs1457804174 1404 dbSNP
rs973302889 1404 dbSNP
rs531398656 1406 dbSNP
rs1422014895 1411 dbSNP
rs1482394461 1414 dbSNP
rs1202248059 1426 dbSNP
rs1166923797 1432 dbSNP
rs997289153 1436 dbSNP
rs564192942 1438 dbSNP
rs372156656 1445 dbSNP
rs1036082634 1459 dbSNP
rs11541318 1460 dbSNP
rs766334723 1461 dbSNP
rs1379906254 1463 dbSNP
rs1440753372 1465 dbSNP
rs1173391452 1470 dbSNP
rs1034965662 1473 dbSNP
rs1464172301 1476 dbSNP
rs149307123 1482 dbSNP
rs1402236687 1490 dbSNP
rs1048975415 1503 dbSNP
rs553528705 1514 dbSNP
rs750366952 1515 dbSNP
rs189344461 1519 dbSNP
rs1021079492 1520 dbSNP
rs1379003774 1521 dbSNP
rs1252342643 1525 dbSNP
rs1196172344 1533 dbSNP
rs1183680324 1534 dbSNP
rs927338775 1537 dbSNP
rs981391690 1538 dbSNP
rs1235629632 1541 dbSNP
rs1263678119 1543 dbSNP
rs950168716 1546 dbSNP
rs893608514 1549 dbSNP
rs1038900595 1551 dbSNP
rs1458603731 1564 dbSNP
rs943246082 1567 dbSNP
rs1359590024 1568 dbSNP
rs1308041813 1575 dbSNP
rs1051413811 1576 dbSNP
rs1177741136 1576 dbSNP
rs890399469 1576 dbSNP
rs929019207 1576 dbSNP
rs1402373557 1578 dbSNP
rs573999731 1589 dbSNP
rs1337188936 1590 dbSNP
rs918997377 1599 dbSNP
rs988870751 1602 dbSNP
rs1388262601 1605 dbSNP
rs1302301693 1607 dbSNP
rs1340108550 1620 dbSNP
rs957777210 1624 dbSNP
rs1033172417 1632 dbSNP
rs767518710 1634 dbSNP
rs1389203402 1640 dbSNP
rs367691583 1649 dbSNP
rs1221417342 1651 dbSNP
rs12452757 1657 dbSNP
rs184925642 1658 dbSNP
rs772929165 1659 dbSNP
rs1192120488 1671 dbSNP
rs1044410 1675 dbSNP
rs1190889806 1684 dbSNP
rs1425089169 1685 dbSNP
rs1471247053 1696 dbSNP
rs180701378 1723 dbSNP
rs539586700 1725 dbSNP
rs188245990 1729 dbSNP
rs1459303539 1730 dbSNP
rs1293893409 1736 dbSNP
rs547476083 1740 dbSNP
rs1004602906 1741 dbSNP
rs1398322222 1749 dbSNP
rs529174091 1753 dbSNP
rs1341172983 1754 dbSNP
rs1227783476 1756 dbSNP
rs1311272790 1758 dbSNP
rs1324023213 1761 dbSNP
rs1222774663 1766 dbSNP
rs1285680018 1772 dbSNP
rs1213956812 1777 dbSNP
rs1487768564 1777 dbSNP
rs1265152138 1778 dbSNP
rs1264840660 1783 dbSNP
rs1475482785 1792 dbSNP
rs568377679 1793 dbSNP
rs1180757424 1797 dbSNP
rs887642205 1803 dbSNP
rs1048879793 1811 dbSNP
rs1490503353 1813 dbSNP
rs113089044 1822 dbSNP
rs1213846976 1824 dbSNP
rs1300331463 1830 dbSNP
rs1345991027 1830 dbSNP
rs1447470227 1833 dbSNP
rs1381982993 1838 dbSNP
rs1229339884 1841 dbSNP
rs1309026812 1842 dbSNP
rs1352311750 1879 dbSNP
rs145741911 1881 dbSNP
rs966695882 1884 dbSNP
rs1045597463 1886 dbSNP
rs764320365 1887 dbSNP
rs1235182469 1889 dbSNP
rs1044414 1893 dbSNP
rs775900714 1896 dbSNP
rs1237465658 1901 dbSNP
rs867578993 1903 dbSNP
rs1160226396 1905 dbSNP
rs1007430378 1909 dbSNP
rs1174068568 1918 dbSNP
rs1360921353 1923 dbSNP
rs1453430053 1930 dbSNP
rs545873850 1935 dbSNP
rs1051723750 1936 dbSNP
rs527406146 1937 dbSNP
rs926131910 1939 dbSNP
rs993826570 1943 dbSNP
rs1310365363 1944 dbSNP
rs1350963076 1946 dbSNP
rs1218228051 1951 dbSNP
rs1292011419 1956 dbSNP
rs1402587746 1967 dbSNP
rs1385926453 1968 dbSNP
rs1172259140 1969 dbSNP
rs1387266399 1971 dbSNP
rs1426898022 1972 dbSNP
rs1201349316 1977 dbSNP
rs1313485867 1981 dbSNP
rs1203731203 1984 dbSNP
rs1237557567 1989 dbSNP
rs1364775466 1989 dbSNP
rs1456385674 1989 dbSNP
rs776556311 1989 dbSNP
rs1161395438 1990 dbSNP
rs759092791 1990 dbSNP
rs1330846131 2004 dbSNP
rs1480692004 2006 dbSNP
rs1434729652 2010 dbSNP
rs985612655 2011 dbSNP
rs560047966 2015 dbSNP
rs1346993306 2024 dbSNP
rs954165496 2032 dbSNP
rs183958814 2033 dbSNP
rs1200408652 2042 dbSNP
rs941766936 2044 dbSNP
rs976963291 2045 dbSNP
rs1480847228 2046 dbSNP
rs567176678 2048 dbSNP
rs140460400 2050 dbSNP
rs1479106942 2051 dbSNP
rs1127814 2052 dbSNP
rs192641880 2055 dbSNP
rs928138339 2057 dbSNP
rs1224514248 2064 dbSNP
rs1317836994 2066 dbSNP
rs1320584203 2066 dbSNP
rs1276923064 2073 dbSNP
rs760056979 2074 dbSNP
rs145143564 2078 dbSNP
rs1001338924 2079 dbSNP
rs539873816 2080 dbSNP
rs1207845929 2081 dbSNP
rs905683803 2082 dbSNP
rs566061100 2090 dbSNP
rs554172941 2103 dbSNP
rs1216115642 2110 dbSNP
rs1014161878 2112 dbSNP
rs1127815 2113 dbSNP
rs747634252 2118 dbSNP
rs936111195 2121 dbSNP
rs1165382821 2129 dbSNP
rs778269137 2130 dbSNP
rs1297247344 2136 dbSNP
rs1358216255 2138 dbSNP
rs954490003 2155 dbSNP
rs772234640 2163 dbSNP
rs1339818087 2166 dbSNP
rs1030179056 2168 dbSNP
rs188404860 2169 dbSNP
rs993400549 2170 dbSNP
rs1459650193 2171 dbSNP
rs1239133693 2179 dbSNP
rs1049816484 2188 dbSNP
rs932808731 2189 dbSNP
rs546646330 2192 dbSNP
rs1255491807 2193 dbSNP
rs1441220358 2198 dbSNP
rs1457634951 2199 dbSNP
rs977442862 2206 dbSNP
rs536530439 2213 dbSNP
rs907557588 2215 dbSNP
rs1340713837 2225 dbSNP
rs750315972 2226 dbSNP
rs780047692 2230 dbSNP
rs755928253 2231 dbSNP
rs116492470 2239 dbSNP
rs552091441 2240 dbSNP
rs1385262544 2241 dbSNP
rs1393760964 2245 dbSNP
rs951688982 2246 dbSNP
rs1337708460 2252 dbSNP
rs1306729595 2258 dbSNP
rs1445863355 2258 dbSNP
rs1318973545 2266 dbSNP
rs1453071010 2271 dbSNP
rs778931092 2280 dbSNP
rs1399325658 2283 dbSNP
rs1255592318 2284 dbSNP
rs1027381603 2289 dbSNP
rs1205626036 2291 dbSNP
rs35507774 2293 dbSNP
rs369761810 2293 dbSNP
rs938441436 2293 dbSNP
rs1457658379 2308 dbSNP
rs928105761 2311 dbSNP
rs1253039714 2331 dbSNP
rs1411534275 2334 dbSNP
rs112118405 2340 dbSNP
rs969897247 2342 dbSNP
rs914165106 2357 dbSNP
rs550749518 2362 dbSNP
rs367964441 2363 dbSNP
rs185038546 2364 dbSNP
rs1406742610 2365 dbSNP
rs891698388 2366 dbSNP
rs1464987574 2367 dbSNP
rs1053416310 2368 dbSNP
rs57441716 2369 dbSNP
rs796988113 2369 dbSNP
rs77958499 2370 dbSNP
rs1391733398 2377 dbSNP
rs1457064241 2386 dbSNP
rs1000218647 2388 dbSNP
rs781120113 2389 dbSNP
rs904485398 2390 dbSNP
rs1283939880 2393 dbSNP
rs1049848224 2398 dbSNP
rs932715540 2399 dbSNP
rs922805842 2402 dbSNP
rs373885675 2403 dbSNP
rs1317861856 2404 dbSNP
rs1438834332 2405 dbSNP
rs1289881792 2408 dbSNP
rs1197260019 2413 dbSNP
rs377684514 2415 dbSNP
rs1253564961 2417 dbSNP
rs1481193865 2424 dbSNP
rs1361744828 2425 dbSNP
rs1266319137 2427 dbSNP
rs529623255 2428 dbSNP
rs1315960641 2430 dbSNP
rs910559376 2434 dbSNP
rs940296774 2435 dbSNP
rs1374969192 2438 dbSNP
rs1429324070 2440 dbSNP
rs143753671 2442 dbSNP
rs543664700 2443 dbSNP
rs562603165 2448 dbSNP
rs1030142109 2450 dbSNP
rs972331997 2451 dbSNP
rs1406941813 2456 dbSNP
rs1322862608 2460 dbSNP
rs576665448 2466 dbSNP
rs961979226 2466 dbSNP
rs984757311 2468 dbSNP
rs1298453526 2470 dbSNP
rs1422176811 2471 dbSNP
rs1244528343 2481 dbSNP
rs1263990173 2482 dbSNP
rs1489735605 2485 dbSNP
rs1016634799 2491 dbSNP
rs1006096332 2498 dbSNP
rs1487707232 2500 dbSNP
rs751719992 2503 dbSNP
rs764076963 2506 dbSNP
rs1421572408 2508 dbSNP
rs1428989319 2514 dbSNP
rs894110813 2516 dbSNP
rs1383109699 2521 dbSNP
rs1426283660 2522 dbSNP
rs950350555 2524 dbSNP
rs1360120298 2538 dbSNP
rs1398304389 2540 dbSNP
rs1290642685 2543 dbSNP
rs1363289375 2548 dbSNP
rs1438635583 2551 dbSNP
rs1395911720 2559 dbSNP
rs920251479 2560 dbSNP
rs1362096149 2562 dbSNP
rs1247152267 2564 dbSNP
rs979859186 2566 dbSNP
rs1044420 2568 dbSNP
rs1470752271 2575 dbSNP
rs193176696 2592 dbSNP
rs1197939857 2594 dbSNP
rs992686881 2596 dbSNP
rs945572762 2598 dbSNP
rs1486171245 2610 dbSNP
rs572633307 2611 dbSNP
rs1031589708 2615 dbSNP
rs370773108 2616 dbSNP
rs904559039 2619 dbSNP
rs1028326161 2623 dbSNP
rs1286682071 2624 dbSNP
rs1399119536 2627 dbSNP
rs1161408089 2633 dbSNP
rs752866652 2634 dbSNP
rs996958722 2635 dbSNP
rs148990901 2636 dbSNP
rs1373831292 2649 dbSNP
rs386796091 2655 dbSNP
rs1041499373 2659 dbSNP
rs11541313 2666 dbSNP
rs759827386 2669 dbSNP
rs536000889 2670 dbSNP
rs1347332671 2672 dbSNP
rs887237314 2673 dbSNP
rs923380340 2676 dbSNP
rs1048672664 2677 dbSNP
rs1208802062 2683 dbSNP
rs1261256408 2684 dbSNP
rs1183988148 2685 dbSNP
rs1462547326 2685 dbSNP
rs1237291917 2686 dbSNP
rs962146535 2687 dbSNP
rs1418638288 2694 dbSNP
rs1179217184 2696 dbSNP
rs147786130 2697 dbSNP
rs984643293 2698 dbSNP
rs920282683 2700 dbSNP
rs1174279424 2701 dbSNP
rs979723659 2709 dbSNP
rs958631620 2713 dbSNP
rs1033956181 2718 dbSNP
rs1401619489 2739 dbSNP
rs1444785688 2741 dbSNP
rs1280988223 2746 dbSNP
rs144319604 2752 dbSNP
rs917023704 2754 dbSNP
rs992947407 2755 dbSNP
rs1325619557 2766 dbSNP
rs955906243 2772 dbSNP
rs538097896 2779 dbSNP
rs1257315820 2781 dbSNP
rs1435918797 2785 dbSNP
rs1206348506 2791 dbSNP
rs1270318605 2792 dbSNP
rs1031914704 2801 dbSNP
rs140263223 2814 dbSNP
rs968605277 2818 dbSNP
rs1197387121 2827 dbSNP
rs1028357463 2830 dbSNP
rs1244025857 2840 dbSNP
rs1480786507 2845 dbSNP
rs773948747 2848 dbSNP
rs1170656488 2851 dbSNP
rs1053972421 2855 dbSNP
rs1329886132 2856 dbSNP
rs1412061716 2856 dbSNP
rs552317678 2867 dbSNP
rs1403903030 2868 dbSNP
rs3203817 2876 dbSNP
rs1300783459 2878 dbSNP
rs1216715127 2881 dbSNP
rs1223572864 2882 dbSNP
rs533734715 2902 dbSNP
rs901147606 2908 dbSNP
rs1311847964 2909 dbSNP
rs936884833 2913 dbSNP
rs1216120754 2920 dbSNP
rs1273384892 2946 dbSNP
rs756579651 2947 dbSNP
rs566361481 2950 dbSNP
rs1004673440 2952 dbSNP
rs147568669 2963 dbSNP
rs116044988 2967 dbSNP
rs562094380 2971 dbSNP
rs1381144678 2972 dbSNP
rs1476642584 2973 dbSNP
rs1168879736 2975 dbSNP
rs775246036 2982 dbSNP
rs550182180 2985 dbSNP
rs905464660 2992 dbSNP
rs769718410 2993 dbSNP
rs1358233962 2999 dbSNP
rs1367041884 3005 dbSNP
rs1045266136 3013 dbSNP
rs745621049 3017 dbSNP
rs1316944982 3020 dbSNP
rs1324638198 3027 dbSNP
rs948392151 3031 dbSNP
rs958600256 3032 dbSNP
rs531995549 3034 dbSNP
rs780837686 3038 dbSNP
rs115575557 3039 dbSNP
rs981073928 3040 dbSNP
rs1471193483 3041 dbSNP
rs1294223409 3051 dbSNP
rs868462776 3055 dbSNP
rs1216057355 3056 dbSNP
rs934403804 3056 dbSNP
rs1194555798 3066 dbSNP
rs1449269958 3066 dbSNP
rs1237360277 3071 dbSNP
rs540267738 3081 dbSNP
rs149886063 3082 dbSNP
rs1170645809 3083 dbSNP
rs924492724 3084 dbSNP
rs1386773393 3085 dbSNP
rs1424880821 3088 dbSNP
rs1157528094 3090 dbSNP
rs878974109 3095 dbSNP
rs1019957474 3096 dbSNP
rs1401891838 3098 dbSNP
rs1318907115 3099 dbSNP
rs978579835 3100 dbSNP
rs1450265965 3105 dbSNP
rs1316874036 3106 dbSNP
rs114342930 3107 dbSNP
rs921201916 3109 dbSNP
rs1205727312 3110 dbSNP
rs1263063134 3113 dbSNP
rs560707171 3115 dbSNP
rs975290727 3117 dbSNP
rs1185868193 3119 dbSNP
rs111780012 3120 dbSNP
rs1439430539 3121 dbSNP
rs1020028137 3123 dbSNP
rs1001062082 3127 dbSNP
rs1470882274 3130 dbSNP
rs1241605863 3131 dbSNP
rs796300230 3138 dbSNP
rs951531472 3139 dbSNP
rs1026996617 3146 dbSNP
rs1406581113 3149 dbSNP
rs1263651542 3151 dbSNP
rs574989579 3156 dbSNP
rs905329104 3157 dbSNP
rs556571295 3159 dbSNP
rs1239935491 3161 dbSNP
rs1282705787 3164 dbSNP
rs1322087131 3167 dbSNP
rs537869251 3173 dbSNP
rs1048871044 3183 dbSNP
rs1381566235 3187 dbSNP
rs1334339441 3188 dbSNP
rs1439180798 3189 dbSNP
rs1182329459 3191 dbSNP
rs937212461 3191 dbSNP
rs1479146259 3194 dbSNP
rs1407244544 3197 dbSNP
rs200768659 3204 dbSNP
rs577204944 3209 dbSNP
rs558553535 3216 dbSNP
rs1398975853 3223 dbSNP
rs1392152140 3224 dbSNP
rs1302742082 3232 dbSNP
rs752919703 3233 dbSNP
rs1057183625 3236 dbSNP
rs765383201 3238 dbSNP
rs1284491581 3248 dbSNP
rs1171221934 3250 dbSNP
rs1423382358 3256 dbSNP
rs1045162 3264 dbSNP
rs1205465870 3271 dbSNP
rs6618 3276 dbSNP
rs1445502994 3282 dbSNP
rs1243476754 3287 dbSNP
rs1268049232 3287 dbSNP
rs766617921 3288 dbSNP
rs1168109804 3289 dbSNP
rs1374619271 3292 dbSNP
rs117902707 3294 dbSNP
rs1163194656 3296 dbSNP
rs1363873447 3297 dbSNP
rs1303824412 3301 dbSNP
rs1406916145 3301 dbSNP
rs1361926719 3305 dbSNP
rs1380991948 3317 dbSNP
rs752797020 3323 dbSNP
rs1308468165 3324 dbSNP
rs1272028988 3327 dbSNP
rs1032796383 3334 dbSNP
rs975364307 3337 dbSNP
rs965652874 3341 dbSNP
rs912590497 3344 dbSNP
rs1312316227 3347 dbSNP
rs866365551 3351 dbSNP
rs201127466 3356 dbSNP
rs1485238578 3362 dbSNP
rs1029177126 3373 dbSNP
rs983198642 3374 dbSNP
rs1263694538 3375 dbSNP
rs773545932 3376 dbSNP
rs1449853679 3377 dbSNP
rs1182748211 3379 dbSNP
rs150808910 3384 dbSNP
rs1045215 3385 dbSNP
rs762488566 3386 dbSNP
rs1390090864 3387 dbSNP
rs1036757694 3391 dbSNP
rs1299297476 3395 dbSNP
rs1313351144 3395 dbSNP
rs995521686 3402 dbSNP
rs550684172 3404 dbSNP
rs775297359 3407 dbSNP
rs1315831035 3409 dbSNP
rs1363752364 3411 dbSNP
rs969558606 3414 dbSNP
rs1322632987 3417 dbSNP
rs1023740503 3420 dbSNP
rs1425475282 3425 dbSNP
rs937436688 3426 dbSNP
rs1241003509 3430 dbSNP
rs375366688 3431 dbSNP
rs769629393 3433 dbSNP
rs1052665990 3434 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.438 1.6e-2 0.422 2.0e-2 24 Click to see details
GSE28260 Renal cortex and medulla -0.439 6.7e-2 -0.456 5.9e-2 13 Click to see details
GSE17498 Multiple myeloma -0.177 1.4e-1 -0.061 3.5e-1 40 Click to see details
GSE42095 Differentiated embryonic stem cells 0.186 2.0e-1 0.250 1.2e-1 23 Click to see details
GSE19783 ER- ER- breast cancer -0.089 2.2e-1 -0.022 4.2e-1 79 Click to see details
GSE21687 Ependynoma primary tumors 0.076 2.8e-1 0.041 3.7e-1 64 Click to see details
GSE19350 CNS germ cell tumors -0.191 2.8e-1 -0.028 4.7e-1 12 Click to see details
GSE26953 Aortic valvular endothelial cells -0.125 2.8e-1 -0.022 4.6e-1 24 Click to see details
GSE19536 Breast cancer -0.037 3.6e-1 0.033 3.7e-1 100 Click to see details
GSE38226 Liver fibrosis -0.081 3.6e-1 -0.023 4.6e-1 21 Click to see details
GSE32688 Pancreatic cancer -0.046 4.0e-1 -0.046 4.0e-1 32 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.036 4.3e-1 -0.109 3.0e-1 25 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis -0.017 4.7e-1 0.217 1.8e-1 20 Click to see details
GSE19783 ER+ ER+ breast cancer -0.004 4.9e-1 0.059 4.0e-1 20 Click to see details
GSE19783 ER+ ER+ breast cancer -0.004 4.9e-1 0.059 4.0e-1 20 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
CHOL 0.374 0.16 0.300 0.22 9 Click to see details
PRAD -0.129 0.19 -0.168 0.12 50 Click to see details
KICH 0.183 0.19 0.199 0.17 25 Click to see details
KIRC 0.097 0.22 0.026 0.42 68 Click to see details
PCPG -0.69 0.26 -0.500 0.33 3 Click to see details
LIHC -0.072 0.31 -0.043 0.38 49 Click to see details
PAAD -0.364 0.32 -0.400 0.3 4 Click to see details
CESC -0.498 0.33 -0.500 0.33 3 Click to see details
COAD 0.138 0.37 0.405 0.16 8 Click to see details
KIRP 0.045 0.4 0.033 0.43 32 Click to see details
UCEC -0.058 0.41 -0.235 0.17 19 Click to see details
ESCA -0.079 0.41 0.018 0.48 11 Click to see details
BRCA 0.022 0.42 -0.007 0.47 84 Click to see details
HNSC 0.028 0.43 0.075 0.32 42 Click to see details
BLCA 0.043 0.43 -0.015 0.48 18 Click to see details
THCA -0.016 0.45 -0.079 0.28 59 Click to see details
LUAD 0.024 0.47 0.252 0.21 12 Click to see details
STAD -0.011 0.48 -0.056 0.38 32 Click to see details
LUSC 0.006 0.49 -0.130 0.22 38 Click to see details
LUSC 0.006 0.49 -0.130 0.22 38 Click to see details
LUSC 0.006 0.49 -0.130 0.22 38 Click to see details
113 hsa-miR-127-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT380928 ZNF264 zinc finger protein 264 2 2
MIRT439324 USP34 ubiquitin specific peptidase 34 1 1
MIRT439333 USP22 ubiquitin specific peptidase 22 1 1
MIRT439379 TTC37 tetratricopeptide repeat domain 37 1 1
MIRT439445 TMEM116 transmembrane protein 116 1 1
MIRT439498 SYNJ2 synaptojanin 2 1 1
MIRT439525 STBD1 starch binding domain 1 1 1
MIRT439562 SORL1 sortilin related receptor 1 1 1
MIRT439660 SF3B1 splicing factor 3b subunit 1 1 1
MIRT439749 ROGDI rogdi homolog 1 1
MIRT439836 RAB3B RAB3B, member RAS oncogene family 1 1
MIRT439923 PPL periplakin 1 1
MIRT439963 PKD1 polycystin 1, transient receptor potential channel interacting 1 1
MIRT439985 PHKG2 phosphorylase kinase catalytic subunit gamma 2 1 1
MIRT440029 PCLO piccolo presynaptic cytomatrix protein 1 1
MIRT440179 MTRNR2L8 MT-RNR2-like 8 1 1
MIRT440183 MTRNR2L4 MT-RNR2-like 4 1 1
MIRT440184 MTRNR2L6 MT-RNR2-like 6 1 1
MIRT440194 MTRNR2L1 MT-RNR2-like 1 1 1
MIRT440269 MBP myelin basic protein 1 1
MIRT440323 LIN7C lin-7 homolog C, crumbs cell polarity complex component 1 1
MIRT440331 LGALS8 galectin 8 1 1
MIRT440355 KLHL29 kelch like family member 29 1 1
MIRT440397 KDM6B lysine demethylase 6B 1 1
MIRT440411 KAT2B lysine acetyltransferase 2B 1 1
MIRT440424 ITCH itchy E3 ubiquitin protein ligase 1 1
MIRT440651 FBXO7 F-box protein 7 1 1
MIRT440773 DST dystonin 1 1
MIRT440824 DGKD diacylglycerol kinase delta 1 1
MIRT440914 COPA coatomer protein complex subunit alpha 1 1
MIRT441118 BBS4 Bardet-Biedl syndrome 4 1 1
MIRT441153 ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 1 1
MIRT441193 ARID1A AT-rich interaction domain 1A 1 1
MIRT441260 ADM adrenomedullin 1 1
MIRT441282 ACTB actin beta 1 1
MIRT441306 ABHD2 abhydrolase domain containing 2 1 1
MIRT441860 TEX35 testis expressed 35 2 2
MIRT442190 CCDC132 VPS50, EARP/GARPII complex subunit 2 2
MIRT442886 RHCG Rh family C glycoprotein 2 2
MIRT444158 ZNF701 zinc finger protein 701 2 2
MIRT444506 ZNF525 zinc finger protein 525 2 2
MIRT444770 NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 2 2
MIRT445830 SRSF11 serine and arginine rich splicing factor 11 2 2
MIRT445850 LRRC1 leucine rich repeat containing 1 2 2
MIRT445863 ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2 2
MIRT446161 C8A complement C8 alpha chain 2 2
MIRT447117 SLFN5 schlafen family member 5 2 2
MIRT447990 CDX1 caudal type homeobox 1 2 2
MIRT449032 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 2 2
MIRT449295 SMIM19 small integral membrane protein 19 2 2
MIRT449541 PCDH9 protocadherin 9 2 2
MIRT449579 ZNF510 zinc finger protein 510 2 2
MIRT450062 SYT9 synaptotagmin 9 2 2
MIRT450437 CAPZA1 capping actin protein of muscle Z-line alpha subunit 1 2 2
MIRT450449 ZDHHC2 zinc finger DHHC-type containing 2 2 2
MIRT450695 RORA RAR related orphan receptor A 2 2
MIRT453654 RAB6C RAB6C, member RAS oncogene family 2 2
MIRT463771 YOD1 YOD1 deubiquitinase 2 2
MIRT468425 SETD1B SET domain containing 1B 2 2
MIRT468843 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT475594 HMGB2 high mobility group box 2 4 4
MIRT478284 DDX19A DEAD-box helicase 19A 2 2
MIRT487594 NKD2 naked cuticle homolog 2 2 4
MIRT493440 KANSL1 KAT8 regulatory NSL complex subunit 1 2 6
MIRT496169 RPL35A ribosomal protein L35a 2 4
MIRT497566 CCR6 C-C motif chemokine receptor 6 2 2
MIRT497917 BTG1 BTG anti-proliferation factor 1 2 2
MIRT498331 PRELID2 PRELI domain containing 2 2 2
MIRT498369 KLHL11 kelch like family member 11 2 2
MIRT498856 LITAF lipopolysaccharide induced TNF factor 2 2
MIRT505640 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT506128 PLRG1 pleiotropic regulator 1 2 4
MIRT512242 ARPP19 cAMP regulated phosphoprotein 19 2 4
MIRT512489 ARID2 AT-rich interaction domain 2 2 2
MIRT525251 RNF213 ring finger protein 213 2 2
MIRT530197 ALX1 ALX homeobox 1 2 4
MIRT530551 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT534048 STC2 stanniocalcin 2 2 2
MIRT537508 FAM105A family with sequence similarity 105 member A 2 2
MIRT543005 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT543814 SNX10 sorting nexin 10 2 2
MIRT549303 ARID5B AT-rich interaction domain 5B 2 2
MIRT549407 ADIPOR2 adiponectin receptor 2 2 4
MIRT550547 ARSK arylsulfatase family member K 2 2
MIRT554319 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT554515 RUFY2 RUN and FYVE domain containing 2 2 2
MIRT559603 AMOT angiomotin 2 2
MIRT564844 ZBED3 zinc finger BED-type containing 3 2 2
MIRT566125 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT567484 FOXK1 forkhead box K1 2 2
MIRT576521 Txlna taxilin alpha 2 2
MIRT633635 CASC5 kinetochore scaffold 1 2 2
MIRT639325 C9orf41 carnosine N-methyltransferase 1 2 2
MIRT643174 MDM2 MDM2 proto-oncogene 2 2
MIRT651214 ZNF225 zinc finger protein 225 2 2
MIRT653039 STRIP2 striatin interacting protein 2 2 2
MIRT653042 STOX2 storkhead box 2 2 2
MIRT658769 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT666728 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT681223 DUSP19 dual specificity phosphatase 19 2 2
MIRT685562 SRD5A3 steroid 5 alpha-reductase 3 2 2
MIRT687434 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT688439 DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 2 2
MIRT692707 MEAF6 MYST/Esa1 associated factor 6 2 2
MIRT700552 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT704955 CBX2 chromobox 2 2 2
MIRT714524 ALKBH3 alkB homolog 3, alpha-ketoglutaratedependent dioxygenase 2 2
MIRT716225 DGKI diacylglycerol kinase iota 2 2
MIRT717953 MIA3 MIA family member 3, ER export factor 2 2
MIRT719902 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT732044 BLVRB biliverdin reductase B 3 1
MIRT733622 SNX5 sorting nexin 5 3 0
MIRT737210 CXCR4 C-X-C motif chemokine receptor 4 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-127 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR rat breast 17700064 2007 down-regulated
miR-127 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) NULL NULL Microarray T24 human bladder cancer cells 16766263 2006 up-regulated
miR-127 17beta-estradiol (E2) approved 5757 Microarray rat breast 17700064 2007 down-regulated
miR-127-5p Glucose NULL 5793 Microarray endothelial cells 24394957 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-127 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-mir-127 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-miR-127-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-127-5p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM11)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-127-5p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-127-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-127-5p Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR200)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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