miRTarBase - #MIRT439356


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pre-miRNA Information
pre-miRNA hsa-mir-136   
Genomic Coordinates chr14: 100884702 - 100884783
Description Homo sapiens miR-136 stem-loop
Comment miR-136 was first identified by cloning studies in mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-136-3p
Sequence 49| CAUCAUCGUCUCAAAUGAGUCU |70
Evidence Experimental
Experiments Cloned
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
C-to-U 12 14 + 100884761 26209130 MiREDiBase
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM7823565 1 COSMIC
COSM3493816 7 COSMIC
COSM1368268 8 COSMIC
COSM7310051 10 COSMIC
COSM1368269 14 COSMIC
COSM1368270 19 COSMIC
COSM344261 20 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs147448304 2 dbSNP
rs371763274 7 dbSNP
rs775059932 8 dbSNP
rs1396077682 16 dbSNP
rs761406043 18 dbSNP
rs767143412 19 dbSNP
rs375044864 20 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol UBE3C   
Synonyms HECTH2
Description ubiquitin protein ligase E3C
Transcript NM_014671   
Expression
Putative miRNA Targets on UBE3C
3'UTR of UBE3C
(miRNA target sites are highlighted)		 
>UBE3C|NM_014671|3'UTR
   1 AGCTGATGCTGGGGTCAGACCCCTACAGAGAACCAGTGCTTCCTTCGTCAGCAGCGCCTCCCCAGACCCACGAGGATACT
  81 CACACTGCACGCCTGAGGCTCTCCTAAGCTCCTTCTTTCATTCTGCCATTCCTCCCTCCCTTCCTTTTTTAAATGATTTT
 161 TATTACGGTGTGGTCACTTATTTAGATGGACATTGCTTTTCAAATAACTTAAAATAACACGTTATGTGCCATGTGGCTAC
 241 TTTAGTAATATTGCCAAGAAGAGCACAGTTTTTACACTAGTGGCATCTCAGTGAAATTAACCAAAGATGAAGCTTTGGCT
 321 TTGCTGGTGAGATCAGAGCCCTCCTGAGCAGGCAGCGCCACTCCAGGGTTCAGACAGGGCTGCACAGGCGGCAGAGATAC
 401 AGGGTCTGAGGGCTGAGACGCCATGGGGCCGCTGCTGCTTATGTGGTTGGATTGTTTACAAGCCTCATTATTAAAACTGA
 481 AGGCATTTTTTTTTTCTGCTGCCTTTCCCAAAGTGGTTAGGTTTGGAAAAGAGATGATGATGGTAATATTTTATTTGTGC
 561 TTTTTAAGCCATTTCCCCAAATGGGACTAGCATGCTTGTTTTCAGTATACCGTGGCCTGCCTCATGATGGTTTGGAGATA
 641 CTGTCTGTGGATGTGAGGTGGGGACTTCATTCATTGTCCTATTTCTATCTCCACTTTGTGCCTGGAGAGCTTTCAGGGGA
 721 GGTGGAGGAGGAGGGTCTGCCAAGCTACTGCAACATCTGTCACCCACTATACCCAGTTACTTGGGGGAGGACAGACACTG
 801 TGGTGTCATTAAAGTTGTTTGAACCAAAGTGGCGGCTGCATCTTTGTCCCGATGCTAGCCGTGCCGGTCTCCCATCATCC
 881 GCTCGCCCTCCTTTCCCCTGGGCTGCGCCCACTTGTCTTCCTGGATATTTGGGGGTGACTCGCCATGCTTGGCACCCTCT
 961 GCTTCCTGGTGCTGCTCTGACTCGAAGACGGGACAGTCCCTGGTGCACATCCAGGGAAGAGGAGTGTCGGTAGTTCTTGC
1041 AGTAGGCACTTTATCAGGACCTGACCTGTTGCTGGGTGATTTTAGTCTCTACAAACAGAAAGCGTTTCAAAGCGTCAGCT
1121 GTGGGAGCAGAGTGACCCTTTGCTGATGCTGGGGGGAGGGGATCTAAATCCTCATTTATCTCTTCTATGTCTCGTATTTT
1201 ACTGTCACTGGAGGCTCTGTGGGCTGTCATAGTTAATTGACCATAATTAGCAATATACTTTTAAAGTGGGAAAGCTGAAT
1281 GACACTTTTAAGACAATGAACATTATCAAAACAAAATGTATAATTTCTTAATTTGAATAATAAATTAAGCGTTTAAATGC
1361 TATTTGTAGTCTTGATATACAGAAATAAAATAATTAGGGTTGGTCTTTTTTATTTTAGGTTGTTTTATGTTGAATGTTCT
1441 ATATCTTATTAGTTAATTTGTATATTTTATTAGTATTTTGGAAATAGCATATCTGAGACTGAAGAGAAATTGACAATTCA
1521 CTTATTTGTGGTTTTTTTCTCAGCTATTCTGAGCTTATTTATTTATTTGTATGTTCTAATGGCTAAACATTTACATTAAA
1601 TGTTTTTTTTCCCAAGAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' ucugaguaaaCUCUGCUACUAc 5'
                    ||||:|||||| 
Target 5' gtttggaaaaGAGATGATGATg 3'
 521 - 542 144.00 -18.60
2 
miRNA  3' ucUGAGUAAACUCUGCUACUac 5'
            || | ||| |||| ||||  
Target 5' tgACACTTTTAAGACAATGAac 3'
 1280 - 1301 124.00 -8.50
3 
miRNA  3' ucUGA-GU--AAACUCUGCUACUAc 5'
            :|| ||  ||||   ||||| | 
Target 5' cgGCTGCATCTTTGTCCCGATGCTa 3'
 833 - 857 122.00 -9.82
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN31517053 47 COSMIC
COSN30184509 57 COSMIC
COSN30483022 62 COSMIC
COSN14274984 72 COSMIC
COSN30497642 91 COSMIC
COSN30189306 92 COSMIC
COSN28201497 133 COSMIC
COSN31559173 197 COSMIC
COSN30542349 230 COSMIC
COSN31517062 299 COSMIC
COSN31557177 420 COSMIC
COSN29461257 467 COSMIC
COSN29537045 496 COSMIC
COSN32064458 648 COSMIC
COSN7971387 785 COSMIC
COSN31489094 822 COSMIC
COSN31536923 834 COSMIC
COSN6872781 852 COSMIC
COSN22385437 985 COSMIC
COSN32063337 1011 COSMIC
COSN9979601 1070 COSMIC
COSN8516111 1114 COSMIC
COSN29073546 1119 COSMIC
COSN22167702 1151 COSMIC
COSN31542027 1161 COSMIC
COSN19658467 1188 COSMIC
COSN26569066 1271 COSMIC
COSN31548238 1328 COSMIC
COSN31528126 1351 COSMIC
COSN22667179 1498 COSMIC
COSN6872782 1547 COSMIC
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs756312692 4 dbSNP
rs774365547 5 dbSNP
rs1415816347 7 dbSNP
rs761987137 11 dbSNP
rs780368185 15 dbSNP
rs554897617 17 dbSNP
rs1290146337 18 dbSNP
rs767451038 20 dbSNP
rs764708341 21 dbSNP
rs775896885 22 dbSNP
rs369675419 23 dbSNP
rs1303863973 27 dbSNP
rs371465790 33 dbSNP
rs748084785 37 dbSNP
rs1276836654 39 dbSNP
rs1364288363 43 dbSNP
rs771534714 44 dbSNP
rs777290907 45 dbSNP
rs746583644 47 dbSNP
rs142368430 48 dbSNP
rs776413330 51 dbSNP
rs1253986408 52 dbSNP
rs1412946789 56 dbSNP
rs543944091 57 dbSNP
rs577901989 66 dbSNP
rs555970252 67 dbSNP
rs1449395291 72 dbSNP
rs1383883005 73 dbSNP
rs1246794209 75 dbSNP
rs58776863 80 dbSNP
rs999382850 85 dbSNP
rs867804651 91 dbSNP
rs988947177 92 dbSNP
rs1209016990 95 dbSNP
rs145961178 104 dbSNP
rs202090604 112 dbSNP
rs1253547418 115 dbSNP
rs1009087496 123 dbSNP
rs1295385173 127 dbSNP
rs1437153268 128 dbSNP
rs1365704822 129 dbSNP
rs76065469 133 dbSNP
rs1446106976 140 dbSNP
rs986131272 141 dbSNP
rs182996339 143 dbSNP
rs540924636 145 dbSNP
rs1279770576 160 dbSNP
rs1388376954 166 dbSNP
rs973059561 167 dbSNP
rs757934547 168 dbSNP
rs1255922199 169 dbSNP
rs562105461 178 dbSNP
rs1027364532 182 dbSNP
rs1185022139 188 dbSNP
rs77315883 193 dbSNP
rs983572680 197 dbSNP
rs773878846 204 dbSNP
rs1482468326 205 dbSNP
rs371104534 210 dbSNP
rs1230553924 221 dbSNP
rs377733726 225 dbSNP
rs551079336 226 dbSNP
rs990636973 231 dbSNP
rs916483301 239 dbSNP
rs1381050786 241 dbSNP
rs896340806 243 dbSNP
rs1460397141 244 dbSNP
rs1012089099 266 dbSNP
rs946668300 268 dbSNP
rs1430961603 283 dbSNP
rs1167167346 284 dbSNP
rs903809681 290 dbSNP
rs75383598 291 dbSNP
rs371870345 301 dbSNP
rs1188257722 302 dbSNP
rs1472034065 303 dbSNP
rs956072625 313 dbSNP
rs1206592645 314 dbSNP
rs1480668802 319 dbSNP
rs1264850256 330 dbSNP
rs1219253401 335 dbSNP
rs1029809931 347 dbSNP
rs1293636306 349 dbSNP
rs761486120 357 dbSNP
rs1348789047 358 dbSNP
rs1405469017 374 dbSNP
rs185237066 375 dbSNP
rs890569912 376 dbSNP
rs1297810900 379 dbSNP
rs1325266839 383 dbSNP
rs1459866317 390 dbSNP
rs911459720 391 dbSNP
rs941653528 393 dbSNP
rs974110229 395 dbSNP
rs1472061141 399 dbSNP
rs1227311550 418 dbSNP
rs779878172 420 dbSNP
rs1284370562 421 dbSNP
rs1009469289 424 dbSNP
rs1489394808 429 dbSNP
rs1039254040 431 dbSNP
rs1207951828 432 dbSNP
rs551249224 433 dbSNP
rs1260795040 436 dbSNP
rs1326801966 441 dbSNP
rs1270308487 450 dbSNP
rs1056153412 453 dbSNP
rs1330632700 455 dbSNP
rs900754646 458 dbSNP
rs995049511 459 dbSNP
rs896264342 460 dbSNP
rs1044939877 486 dbSNP
rs903735099 486 dbSNP
rs947888257 486 dbSNP
rs1263206605 497 dbSNP
rs1426713433 498 dbSNP
rs1192345953 499 dbSNP
rs1429777503 500 dbSNP
rs1391256444 501 dbSNP
rs1481267920 501 dbSNP
rs1174562885 502 dbSNP
rs1428937384 503 dbSNP
rs1454490142 504 dbSNP
rs1027917349 510 dbSNP
rs1453960321 512 dbSNP
rs1376597747 516 dbSNP
rs950406177 521 dbSNP
rs1000794805 528 dbSNP
rs780576435 530 dbSNP
rs1004570321 532 dbSNP
rs566435216 534 dbSNP
rs533882746 540 dbSNP
rs1253610526 544 dbSNP
rs1187827941 547 dbSNP
rs1035164642 554 dbSNP
rs868037294 556 dbSNP
rs1249624953 558 dbSNP
rs960514918 559 dbSNP
rs1205970622 561 dbSNP
rs1344516119 573 dbSNP
rs1254344609 579 dbSNP
rs1235593270 584 dbSNP
rs191225704 588 dbSNP
rs1347789958 591 dbSNP
rs1222001510 596 dbSNP
rs749925667 607 dbSNP
rs566958029 612 dbSNP
rs967856657 613 dbSNP
rs1382449355 616 dbSNP
rs143332946 621 dbSNP
rs769012617 624 dbSNP
rs955479603 625 dbSNP
rs1262021208 631 dbSNP
rs117165702 640 dbSNP
rs1447532762 640 dbSNP
rs1391803142 641 dbSNP
rs755437167 647 dbSNP
rs1441624515 651 dbSNP
rs1053156427 654 dbSNP
rs1254399002 658 dbSNP
rs1269440554 663 dbSNP
rs201686667 665 dbSNP
rs1490818957 670 dbSNP
rs577632246 673 dbSNP
rs911958593 678 dbSNP
rs1202371000 680 dbSNP
rs1197084422 686 dbSNP
rs540025724 688 dbSNP
rs1226864261 700 dbSNP
rs1344864678 701 dbSNP
rs1271140581 713 dbSNP
rs756162380 720 dbSNP
rs1244591961 724 dbSNP
rs1339054571 726 dbSNP
rs963247970 727 dbSNP
rs1419937553 738 dbSNP
rs974369488 740 dbSNP
rs987093823 746 dbSNP
rs1427751223 748 dbSNP
rs1398635920 749 dbSNP
rs951037262 758 dbSNP
rs1057014 767 dbSNP
rs1362154896 770 dbSNP
rs944813505 773 dbSNP
rs1453069569 778 dbSNP
rs1251187945 783 dbSNP
rs1475629641 783 dbSNP
rs1164771536 786 dbSNP
rs1203028782 790 dbSNP
rs1368083590 797 dbSNP
rs1403627389 801 dbSNP
rs1302979410 803 dbSNP
rs1209732922 830 dbSNP
rs558114173 833 dbSNP
rs573464770 834 dbSNP
rs995017050 835 dbSNP
rs1049318748 840 dbSNP
rs898732297 847 dbSNP
rs1004941467 851 dbSNP
rs1034724930 852 dbSNP
rs960733612 856 dbSNP
rs1329503314 859 dbSNP
rs766417586 860 dbSNP
rs370262523 861 dbSNP
rs562343774 862 dbSNP
rs967824069 866 dbSNP
rs375017379 867 dbSNP
rs1220116897 870 dbSNP
rs923843531 875 dbSNP
rs1198806041 880 dbSNP
rs1480806805 881 dbSNP
rs574101974 882 dbSNP
rs544244466 883 dbSNP
rs1248599900 884 dbSNP
rs891179889 885 dbSNP
rs572860070 886 dbSNP
rs1226151718 888 dbSNP
rs1018834904 896 dbSNP
rs989217936 900 dbSNP
rs1435689003 905 dbSNP
rs962923423 907 dbSNP
rs10238391 908 dbSNP
rs1441441671 909 dbSNP
rs1387596959 910 dbSNP
rs1025850593 913 dbSNP
rs1402619012 916 dbSNP
rs1408827797 921 dbSNP
rs533224935 926 dbSNP
rs1163464110 928 dbSNP
rs1039109714 936 dbSNP
rs1255514545 941 dbSNP
rs922030293 942 dbSNP
rs930780125 943 dbSNP
rs551852145 945 dbSNP
rs1213238935 958 dbSNP
rs1318286531 960 dbSNP
rs559958037 962 dbSNP
rs886682067 963 dbSNP
rs1218198753 967 dbSNP
rs940991254 970 dbSNP
rs980562758 982 dbSNP
rs1445552796 984 dbSNP
rs35688726 985 dbSNP
rs541873938 985 dbSNP
rs1364220781 990 dbSNP
rs1384310381 991 dbSNP
rs1243709503 995 dbSNP
rs1057118335 997 dbSNP
rs35634293 998 dbSNP
rs527468011 1001 dbSNP
rs1011878102 1007 dbSNP
rs1333743890 1017 dbSNP
rs1307861015 1021 dbSNP
rs1206440707 1023 dbSNP
rs8101 1026 dbSNP
rs567195854 1029 dbSNP
rs537864340 1030 dbSNP
rs1174847958 1033 dbSNP
rs1449338188 1048 dbSNP
rs1388717755 1050 dbSNP
rs759656132 1053 dbSNP
rs1245078247 1054 dbSNP
rs1442807691 1057 dbSNP
rs778706762 1062 dbSNP
rs1420764547 1066 dbSNP
rs781759454 1072 dbSNP
rs1208960243 1080 dbSNP
rs1430806084 1080 dbSNP
rs1168838063 1081 dbSNP
rs1000648889 1092 dbSNP
rs1464806591 1097 dbSNP
rs1234948399 1099 dbSNP
rs555497075 1104 dbSNP
rs549463452 1105 dbSNP
rs868239841 1107 dbSNP
rs1362376097 1108 dbSNP
rs571217833 1111 dbSNP
rs1007356502 1113 dbSNP
rs1039776000 1114 dbSNP
rs966011748 1115 dbSNP
rs1429677408 1119 dbSNP
rs1362651281 1124 dbSNP
rs1173145636 1128 dbSNP
rs538394745 1136 dbSNP
rs374811556 1143 dbSNP
rs898598248 1171 dbSNP
rs553888792 1172 dbSNP
rs1180947605 1174 dbSNP
rs1473988785 1174 dbSNP
rs573502826 1179 dbSNP
rs1211066003 1188 dbSNP
rs534360235 1188 dbSNP
rs556108698 1190 dbSNP
rs7807 1194 dbSNP
rs887321715 1195 dbSNP
rs1013810119 1196 dbSNP
rs1460041107 1199 dbSNP
rs879060304 1206 dbSNP
rs1231697622 1220 dbSNP
rs1357531295 1224 dbSNP
rs1294129952 1225 dbSNP
rs985360065 1232 dbSNP
rs907996338 1237 dbSNP
rs1024570400 1239 dbSNP
rs940860943 1240 dbSNP
rs1185246988 1246 dbSNP
rs1462901961 1249 dbSNP
rs1423381933 1251 dbSNP
rs1480933184 1254 dbSNP
rs1463342971 1256 dbSNP
rs1419654904 1269 dbSNP
rs1056688082 1280 dbSNP
rs896758978 1281 dbSNP
rs1467887878 1285 dbSNP
rs947704117 1286 dbSNP
rs958059010 1287 dbSNP
rs1178897526 1295 dbSNP
rs1480882906 1303 dbSNP
rs1044745745 1305 dbSNP
rs1345242441 1307 dbSNP
rs78004192 1309 dbSNP
rs1000582674 1313 dbSNP
rs1227983250 1317 dbSNP
rs1315223627 1318 dbSNP
rs1309164324 1319 dbSNP
rs987398070 1321 dbSNP
rs1367604202 1324 dbSNP
rs910488526 1339 dbSNP
rs10553043 1341 dbSNP
rs376861022 1341 dbSNP
rs1284954078 1343 dbSNP
rs183346036 1349 dbSNP
rs898546598 1351 dbSNP
rs577965257 1352 dbSNP
rs1419152815 1358 dbSNP
rs1266659844 1364 dbSNP
rs1191647978 1367 dbSNP
rs1253352556 1371 dbSNP
rs1208359605 1372 dbSNP
rs1047194353 1377 dbSNP
rs1262707594 1379 dbSNP
rs1239928802 1383 dbSNP
rs1311653964 1383 dbSNP
rs1301930031 1387 dbSNP
rs1237088934 1391 dbSNP
rs1372215368 1399 dbSNP
rs1285083207 1406 dbSNP
rs887292283 1406 dbSNP
rs1381309845 1407 dbSNP
rs1448760443 1408 dbSNP
rs187545083 1413 dbSNP
rs1025208388 1415 dbSNP
rs10553044 1419 dbSNP
rs796099681 1419 dbSNP
rs1263011907 1422 dbSNP
rs1171721407 1429 dbSNP
rs905483286 1432 dbSNP
rs1490654321 1435 dbSNP
rs1001867954 1437 dbSNP
rs1008497994 1440 dbSNP
rs1187770857 1442 dbSNP
rs1267190921 1443 dbSNP
rs771706596 1444 dbSNP
rs112334423 1446 dbSNP
rs1205907255 1446 dbSNP
rs772907241 1449 dbSNP
rs1019525197 1450 dbSNP
rs1349151634 1453 dbSNP
rs963986260 1453 dbSNP
rs1297507231 1456 dbSNP
rs1328543534 1457 dbSNP
rs974733617 1459 dbSNP
rs1297327111 1461 dbSNP
rs1401882785 1463 dbSNP
rs1029036346 1465 dbSNP
rs957769408 1466 dbSNP
rs1310469530 1467 dbSNP
rs115049391 1470 dbSNP
rs1376054546 1477 dbSNP
rs1020771068 1487 dbSNP
rs1405469908 1488 dbSNP
rs1474325386 1489 dbSNP
rs984857266 1494 dbSNP
rs954514134 1501 dbSNP
rs527506565 1513 dbSNP
rs548734722 1515 dbSNP
rs199863451 1517 dbSNP
rs560859787 1517 dbSNP
rs531553237 1525 dbSNP
rs1190240032 1528 dbSNP
rs1486033998 1529 dbSNP
rs1252202271 1532 dbSNP
rs1341949032 1532 dbSNP
rs943289848 1532 dbSNP
rs992757931 1532 dbSNP
rs550039674 1539 dbSNP
rs975401631 1543 dbSNP
rs948348388 1546 dbSNP
rs919940070 1547 dbSNP
rs1436053055 1555 dbSNP
rs770382381 1555 dbSNP
rs1045293703 1556 dbSNP
rs556076784 1559 dbSNP
rs1352936559 1567 dbSNP
rs924917300 1570 dbSNP
rs1398377444 1571 dbSNP
rs571188663 1575 dbSNP
rs1285376614 1579 dbSNP
rs936347984 1589 dbSNP
rs1052167334 1601 dbSNP
rs1322600695 1603 dbSNP
rs143591506 1603 dbSNP
rs949554144 1605 dbSNP
rs892235252 1611 dbSNP
rs905408703 1611 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28544 Breast cancer 0.656 2.5e-4 0.545 2.9e-3 24 Click to see details
GSE19350 CNS germ cell tumors -0.768 1.8e-3 -0.552 3.1e-2 12 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.427 1.7e-2 0.281 8.7e-2 25 Click to see details
GSE19783 ER+ ER+ breast cancer -0.432 2.9e-2 -0.418 3.3e-2 20 Click to see details
GSE19536 Breast cancer -0.18 3.7e-2 -0.163 5.3e-2 100 Click to see details
GSE21687 Ependynoma primary tumors 0.221 4.0e-2 -0.032 4.0e-1 64 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.361 5.9e-2 0.481 1.6e-2 20 Click to see details
GSE32688 Pancreatic cancer -0.271 6.7e-2 -0.183 1.6e-1 32 Click to see details
GSE19783 ER- ER- breast cancer -0.16 7.9e-2 -0.075 2.6e-1 79 Click to see details
GSE28260 Renal cortex and medulla 0.335 1.3e-1 0.451 6.1e-2 13 Click to see details
GSE26953 Aortic valvular endothelial cells 0.216 1.6e-1 0.214 1.6e-1 24 Click to see details
GSE17498 Multiple myeloma -0.131 2.1e-1 -0.164 1.6e-1 40 Click to see details
GSE42095 Differentiated embryonic stem cells 0.142 2.6e-1 0.175 2.1e-1 23 Click to see details
GSE35602 Colorectal cancer stromal tissue 0.121 2.8e-1 0.420 1.8e-2 25 Click to see details
GSE38226 Liver fibrosis 0.128 2.9e-1 0.002 5.0e-1 21 Click to see details
GSE21032 Prostate cancer 0.016 4.4e-1 0.012 4.6e-1 83 Click to see details
GSE15076 Monocyte-derived dendritic cells 0.089 4.4e-1 0.000 5.0e-1 5 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
ESCA -0.659 0.01 -0.600 0.03 11 Click to see details
BLCA -0.416 0.04 -0.397 0.05 18 Click to see details
LUSC -0.263 0.06 -0.205 0.11 38 Click to see details
STAD -0.285 0.06 -0.322 0.04 32 Click to see details
CHOL -0.48 0.1 -0.483 0.09 9 Click to see details
UCEC -0.288 0.12 -0.203 0.21 18 Click to see details
PCPG -0.921 0.13 -0.500 0.33 3 Click to see details
KICH 0.198 0.18 0.170 0.21 24 Click to see details
PRAD -0.113 0.22 -0.083 0.28 50 Click to see details
LIHC -0.109 0.23 -0.104 0.24 49 Click to see details
KIRC 0.1 0.23 0.058 0.34 56 Click to see details
LUAD 0.209 0.26 0.112 0.36 12 Click to see details
THCA 0.088 0.26 0.079 0.28 56 Click to see details
CESC -0.67 0.27 -0.500 0.33 3 Click to see details
KIRP 0.116 0.27 0.086 0.33 30 Click to see details
HNSC -0.052 0.37 -0.097 0.27 42 Click to see details
PAAD -0.106 0.45 -0.200 0.4 4 Click to see details
BRCA -0.009 0.47 -0.014 0.45 83 Click to see details
BRCA -0.009 0.47 -0.014 0.45 83 Click to see details
BRCA -0.009 0.47 -0.014 0.45 83 Click to see details
BRCA -0.009 0.47 -0.014 0.45 83 Click to see details
46 hsa-miR-136-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT256787 CANX calnexin 1 1
MIRT380416 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 1 1
MIRT439175 ZRANB1 zinc finger RANBP2-type containing 1 1 1
MIRT439356 UBE3C ubiquitin protein ligase E3C 1 1
MIRT439465 TGFBR3 transforming growth factor beta receptor 3 1 1
MIRT440529 GTF2F1 general transcription factor IIF subunit 1 1 1
MIRT440635 FMN1 formin 1 1 1
MIRT440907 COPS4 COP9 signalosome subunit 4 1 1
MIRT441019 CAND1 cullin associated and neddylation dissociated 1 1 1
MIRT441061 C1orf43 chromosome 1 open reading frame 43 1 1
MIRT441174 ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 1 1
MIRT456146 RWDD2A RWD domain containing 2A 2 16
MIRT483517 PRPF38B pre-mRNA processing factor 38B 2 6
MIRT483556 STX11 syntaxin 11 2 4
MIRT495179 SOX11 SRY-box 11 2 6
MIRT495184 MUC20 mucin 20, cell surface associated 2 2
MIRT499361 MYLK myosin light chain kinase 2 8
MIRT504160 OPN5 opsin 5 2 4
MIRT523975 DVL3 dishevelled segment polarity protein 3 2 2
MIRT524343 CREBRF CREB3 regulatory factor 2 8
MIRT526865 PARP11 poly(ADP-ribose) polymerase family member 11 2 2
MIRT531887 SCN1B sodium voltage-gated channel beta subunit 1 2 2
MIRT533351 UHMK1 U2AF homology motif kinase 1 2 2
MIRT534099 SOX5 SRY-box 5 2 4
MIRT557097 HOXA9 homeobox A9 2 2
MIRT567000 KLHL28 kelch like family member 28 2 2
MIRT568215 C1orf21 chromosome 1 open reading frame 21 2 2
MIRT574254 G6PC glucose-6-phosphatase catalytic subunit 2 2
MIRT614013 PAOX polyamine oxidase 2 2
MIRT615541 PHF1 PHD finger protein 1 2 2
MIRT622485 REL REL proto-oncogene, NF-kB subunit 2 2
MIRT623683 HOXB6 homeobox B6 2 2
MIRT630575 PLXDC2 plexin domain containing 2 2 4
MIRT642865 FAM227A family with sequence similarity 227 member A 2 2
MIRT649932 TTLL7 tubulin tyrosine ligase like 7 2 2
MIRT654531 RAB3GAP2 RAB3 GTPase activating non-catalytic protein subunit 2 2 2
MIRT656989 KDM5A lysine demethylase 5A 2 2
MIRT668527 ERP44 endoplasmic reticulum protein 44 2 2
MIRT693411 NUDT16 nudix hydrolase 16 2 2
MIRT700692 POLR3D RNA polymerase III subunit D 2 2
MIRT712284 PPIP5K2 diphosphoinositol pentakisphosphate kinase 2 2 2
MIRT717286 TRAF1 TNF receptor associated factor 1 2 2
MIRT724396 IQGAP1 IQ motif containing GTPase activating protein 1 2 2
MIRT725201 PTRF caveolae associated protein 1 2 2
MIRT731933 NOTCH3 notch 3 2 1
MIRT756476 BMPR1B bone morphogenetic protein receptor type 1B 3 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-136 Lithium (Li) approved 3028194 Microarray rat hippocampus 18704095 2009 up-regulated
miR-136 Valproate approved 3121 Microarray rat hippocampus 18704095 2009 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-miR-136-3p Cisplatin 5460033 NSC119875 approved sensitive High Ovarian Cancer tissue
hsa-miR-136-3p Imatinib 5291 NSC743414 approved sensitive Low Chronic Myelogenous Leukemia cell line (K562)
hsa-miR-136-3p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-136-3p Palbociclib 5330286 NSC758247 approved resistant tissue (breast cancer)
hsa-miR-136-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-136-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (MGC-803)
hsa-miR-136-3p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-136-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (RPMI2650)
hsa-miR-136-3p Sunitinib 5329102 NSC750690 approved sensitive tissue (CardB)
hsa-miR-136-3p Doxorubicin 31703 NSC123127 approved sensitive cell line (K562)
hsa-miR-136-3p Cisplatin 5460033 NSC119875 approved resistant cell line (IGROV-1)
hsa-miR-136-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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