miRTarBase - #MIRT439452


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pre-miRNA Information
pre-miRNA hsa-mir-539   
Genomic Coordinates chr14: 101047321 - 101047398
Synonyms MIRN539, hsa-mir-539, MIR539
Description Homo sapiens miR-539 stem-loop
Comment None
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-539-3p
Sequence 49| AUCAUACAAGGACAAUUUCUUU |70
Evidence Not_experimental
Experiments
Editing Events in miRNAs
Modification Type Position on miR Chromosome DNA Strand Genomic Position (hg38) List of PMIDs Variant details
A-to-I 9 14 + 101047377 29233923 MiREDiBase
A-to-I 14 14 + 101047382 29233923 MiREDiBase
A-to-I 15 14 + 101047383 29233923 MiREDiBase
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs1163834397 1 dbSNP
rs1249640746 2 dbSNP
rs766009913 2 dbSNP
rs1387109177 3 dbSNP
rs760174615 6 dbSNP
rs755069688 7 dbSNP
rs769402130 12 dbSNP
rs775176241 22 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol TMED10   
Synonyms P24(DELTA), S31I125, S31III125, TMP21, Tmp-21-I, p23, p24d1
Description transmembrane p24 trafficking protein 10
Transcript NM_006827   
Expression
Putative miRNA Targets on TMED10
3'UTR of TMED10
(miRNA target sites are highlighted)		 
>TMED10|NM_006827|3'UTR
   1 TGAATGAGGCATATTCTCCTCCCACCTTGTACCTCAGCCAGCAGAACATCGCTGGGACGTGCCTGGCCTAAGGCATCCTA
  81 CCAACAGCACCATCAAGGCACGTTGGAGCTTTCTTGCCAGAACTGATCTCTTTTGGTGTGGGAGGACATGGGGTACCACC
 161 TACACCCAACAAGTCAATGAGGGACTTCTTTTTAATTTGGTAGGATTTTGACTGGTTTTGCAACAATAGGTCTATTATTA
 241 GAGTCACCTATGACAAAAAATAGGGGTTACCTAGATAATGCCAAAGTCAGCATTTGTCCTGGGTTCCCTTGTGTGATCTG
 321 TTTGGACTATGTTTTCTTTTCTTCTCCCACTTGCTCAGCAGCTTGGGCTTCCATTCTAGTTCTTTTACCAAGATTTTTGT
 401 GTGACCATGTTGACTTCATTTGGATTGCCCTCTTTCAATTTCCTTGTGAAAACACCCTTAACTTTCTCTTTACCCTTAGC
 481 TGAAATGTTTACATAGCTTCTGGTGATATCTTTTCATGATTTTATATCTCTTAAAATGGTGATGGATGTGACACCTCATA
 561 AAAGTGAGCTTTGAACTGTAGATAACTCTTAAAGAAAATGTCATTTTAGACAATTAAAATATTTGTGCTCAACTGCTTGA
 641 ACTTTTTTCGTGTATGTGTATTTAATTCTATGCAATATTATCACATGTGTAGATTCATGTGACCACCATCACAAGAGACA
 721 GAACAGTTCTGTCACATGGATCCCTTGCACTGCCCTTTTACAGCCGCAGCCACATCCCTTTCTTATACCCTCACCCCAAC
 801 CTGTGGCTACCACTGTTCTGTCCTCCATCTCTGTAATTTTGTCATTTCAAGAATGTTGTATGAATGGAATCATACAGAAT
 881 GTAATCTTACGAGGCTGATCTTTTTTCATTCAGCATAATTCCCTTGAAATCCATCCAAGTTGTTGCATGTATGAATAGTT
 961 TCTTCCTTTTTTTCTTTTAAAAATGTTTTATATATTTAGGGGGTATAAGTACAGATTTCTTACATGCATATATTGCATCG
1041 TGGTGAAGTGGGGGCAGTTCCTTTTGATTGCTGAGTAGTATTCCATGGTATGGATGTACCACAGTTTGCTTAACCATTCA
1121 CCCACTAAAGGACATAAGAGTTGTTTTCAGTTTTTTGCCCTAATAAAGCTGCTGTGAACATTCATGTACAGGTTTTTATG
1201 TGAACATACATTTTCATTTTCTGGGATAAATGCTCAAAAGGGCAACTGTTGGGTTGTATGGTAAACACATATATTTTTGT
1281 AAGAAACTACCCTACTCTTTTTCCAGAGTGGCTCTACTTTTTACATACAGCCACTCATACAATTCAGACAGCAATGTATG
1361 ATTGATCCAGTTTCTTCACATCCTCACCAGCATTTGGTATTACTACTATTTTTTATCTTAACCATTCACATAGATGTGTG
1441 TAATGATACCACATGTGGTTTTAATTTGCATTTCCAATGGCTAATGATGTTGAGTATCTTTTTGTGTGCTAATTTGCCAT
1521 CTATGTATCCTCTTCGGTGAAATGTCTTCATGTCTTTTGTCTATTTTCTATTTAGGTCATTTGTTCTTTTTACTATTGAG
1601 TTTTGAGAGGTTTTTTATATATCCTAGATAAAATTCCTCTGTTAGATATGTGGTTGCTTGAATTTTTAACATAACTTCTA
1681 CCAAGGAAAAATAAGTAAAATTTCCAACCCTTGCATGGCCAGTCACTTACTTAATTCCTGTCCTTCAGTGTTCCATCTAG
1761 AGAATTAAGAGATATGATGTATAAAATAGACATCGAGGGCCATTAAGAGAGTAAATACTTAAAAATACATGTTATGAAAG
1841 CAAAGCCAATAATCACTGTAGGAGTATGAGTTGCCTAAGGGCCAAAACTAATGTAAATAAGAGAAAGTGTGGATATAAAT
1921 GACCATTGTTTATAAACAGTTATGAAAAATGCTGTGACTTGAAATCTTTCCCACATCTCCCAAGAAAGTAGGTAGGAGTT
2001 TATCCTTTCCGTAATCTCTTTTTAACCCTGCTGACTATTACAGGGCTTGTTTAATCACAGTGGCAAGAATTACATGTATC
2081 TTACAGTAAAGAAACAGAATACTGGAATCGTTAGAGAACCCTGATGTGTTGACCTGGATAAAGTACAAAGGTGGAAGAGG
2161 GAATGAGTTATGCTGTTAAAATCTCAGGCTATTCTGTTAATGTTCCTGCTACTATGAACCCAAACTTTTTTTTTCCCCCT
2241 TTTGACTCCTTGTGTCTTCCTCTCCTGTGGCATAAAAGTAGTTCTGTCGTTAACTTGTACAACATTGCCATCTGCTGTTG
2321 AGAATTGGTAGGTACTGCTTCTGAGAACCTGGCTGCAGATCCTTAGCATAGGCAGCAAATGTTGAGAAAGTCTATCTGTA
2401 GTATTACATATACTAAGTTACAGAGGATGCATCCAAGTAGAGAAAATAATATGTGGGTTAAGATACATCCTTAAACTTTT
2481 TTTTTTTTGGGGGGGGGGGGACGGAGTCTTGCTGCAACGCCCAGGCTGGAGTGCAATGGCACTATCTCAGCTCGCTGCAA
2561 CCTTCACCTCCTGGGTTCAAGCAATTCTCCTGCCTCAGCCTCCTGAGTAGCTGGGAATATAGGTGCACACCACCATGCCT
2641 GGCTAATTTTTGTATTTTCAGTAGAAGCAGAGTTTCACCATATTGGCCAGGTTGGTCTCGAACTCCTGACCTCAAGTGAT
2721 CTGCCTGCCTCAGCCTCCCAAAGTGCTGGGATTACACGCGTGAGCCACCACACCCAGCCTCCATCTTTAAACTTTTAAAT
2801 GTGAAATTTCTATCATGTACCGTTAGCCTAACAAGATTTTCTTTCCTATTTCTGACTGGTGCCTTTCCCCTTTTTAGGAG
2881 CAACGAAAGCTACTCTCTTAGTTATGTTCTTGTGATGTGACAAAATGTCAAGAAGATAGGAGAAGAGAATATTTTATTTC
2961 GTTGATGCTTTTGTTCCCAAGTGTGACCCTAAACTTAAGCTTTGTAGGAGTTGACATTCTTTCATGTCCCTTCCCTTTAC
3041 TCATGCCGAAACTATCAACTGGGACATTTTGTGCTTTTGGTTTAAAAGTTAATTGATATTATACTTTGGTTTTATCTAAA
3121 AAGTAAATGTATTTGCCTTTGACAAAAGACTGACACAAGAGCAAATAAGCTTTAAAATCGGGTGTTATGTGCTTTCCTCC
3201 ATTTTTGAGCATATTATCCAAAATGGTCTGTATAATATAAATGAGAATGATGCAGTTTAAGTAAGCCTTGTTATACCATT
3281 GTCATGGACCCCTGTCATAAAGCCATTTCTTGGTTTGTTTGGGAAAGAGGCATATGGGATTTATACAGATTCACTTGTAA
3361 ATGTTGGATTGGGGATTTTTGTGTAAATTTTCTCAAATAAAGGCTAGCAGAAACCATAAAAAAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uuucUUUAACAG-GAACAUACUa 5'
              ||:||||: | ||||||| 
Target 5' atccAAGTTGTTGCATGTATGAa 3'
 933 - 955 166.00 -11.40
2 
miRNA  3' uuUCUUUAACAGGAACAUACUa 5'
            ||||  ||   |||||||| 
Target 5' caAGAA--TG---TTGTATGAa 3'
 848 - 864 153.00 -7.90
3 
miRNA  3' uuUCUUUAACA---------GGAACAUACUa 5'
            || | ||||         ||||||:||| 
Target 5' tcAGCATTTGTCCTGGGTTCCCTTGTGTGAt 3'
 287 - 317 144.00 -16.10
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30159635 19 COSMIC
COSN32052663 26 COSMIC
COSN30120144 33 COSMIC
COSN1171141 48 COSMIC
COSN30122534 52 COSMIC
COSN30503328 67 COSMIC
COSN30172792 110 COSMIC
COSN30529685 188 COSMIC
COSN5390037 285 COSMIC
COSN31567773 519 COSMIC
COSN31578467 613 COSMIC
COSN26235648 799 COSMIC
COSN9617941 1828 COSMIC
COSN5390036 1834 COSMIC
COSN26209196 1972 COSMIC
COSN21217479 2183 COSMIC
COSN22802955 2226 COSMIC
COSN29474514 2501 COSMIC
COSN6638622 2565 COSMIC
COSN28312199 2759 COSMIC
COSN31590196 2818 COSMIC
COSN17182045 3226 COSMIC
COSN26643777 3283 COSMIC
COSN26665896 3367 COSMIC
rs13099 2433 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs183313033 1 dbSNP
rs1164362243 3 dbSNP
rs1277411750 3 dbSNP
rs754274689 5 dbSNP
rs1413849803 15 dbSNP
rs780216936 16 dbSNP
rs200985530 17 dbSNP
rs756084473 19 dbSNP
rs750674183 23 dbSNP
rs767912356 25 dbSNP
rs1365825248 30 dbSNP
rs1166341231 39 dbSNP
rs762123003 41 dbSNP
rs1416224246 47 dbSNP
rs1418796038 48 dbSNP
rs981588768 50 dbSNP
rs751442420 51 dbSNP
rs750427859 52 dbSNP
rs1224177800 58 dbSNP
rs548462654 59 dbSNP
rs1291395421 62 dbSNP
rs200117044 81 dbSNP
rs1412938860 95 dbSNP
rs1416258129 101 dbSNP
rs190407902 102 dbSNP
rs989752689 114 dbSNP
rs1445915058 119 dbSNP
rs1309768989 126 dbSNP
rs1337333139 131 dbSNP
rs957631507 138 dbSNP
rs866792898 145 dbSNP
rs1313634228 155 dbSNP
rs141840711 162 dbSNP
rs187886161 163 dbSNP
rs776368187 165 dbSNP
rs1420089474 166 dbSNP
rs1414750567 169 dbSNP
rs532054008 177 dbSNP
rs1199852914 182 dbSNP
rs1253241894 191 dbSNP
rs1450245546 194 dbSNP
rs1198533284 205 dbSNP
rs1378483168 227 dbSNP
rs1193404734 235 dbSNP
rs373452683 252 dbSNP
rs886501531 253 dbSNP
rs1027669936 259 dbSNP
rs1422977797 261 dbSNP
rs994823485 261 dbSNP
rs898437473 263 dbSNP
rs1398460605 265 dbSNP
rs1055715135 266 dbSNP
rs1331370647 269 dbSNP
rs1224943901 275 dbSNP
rs937223087 281 dbSNP
rs1316792702 294 dbSNP
rs907039749 299 dbSNP
rs12527 300 dbSNP
rs12528 303 dbSNP
rs768185490 315 dbSNP
rs1049318 317 dbSNP
rs1268452632 320 dbSNP
rs866511769 320 dbSNP
rs945807469 320 dbSNP
rs1490914990 323 dbSNP
rs1191806070 326 dbSNP
rs1262695201 337 dbSNP
rs1478191174 355 dbSNP
rs1172546230 357 dbSNP
rs1374791407 358 dbSNP
rs1456302766 362 dbSNP
rs1429895316 363 dbSNP
rs1162484834 365 dbSNP
rs1257593119 369 dbSNP
rs1212446078 375 dbSNP
rs1484676068 379 dbSNP
rs555008675 390 dbSNP
rs1216188072 399 dbSNP
rs1339385199 401 dbSNP
rs989803451 408 dbSNP
rs1318507733 409 dbSNP
rs1297090870 419 dbSNP
rs13564 437 dbSNP
rs183202842 438 dbSNP
rs191818816 446 dbSNP
rs1362080486 448 dbSNP
rs1214819329 455 dbSNP
rs774838458 462 dbSNP
rs1804659 465 dbSNP
rs922227554 467 dbSNP
rs1488731250 474 dbSNP
rs975394118 478 dbSNP
rs771650308 489 dbSNP
rs1254145936 492 dbSNP
rs966280113 496 dbSNP
rs1049408 519 dbSNP
rs1049409 524 dbSNP
rs1186789507 551 dbSNP
rs1468799441 552 dbSNP
rs1385719599 554 dbSNP
rs539946453 558 dbSNP
rs1156602405 568 dbSNP
rs1232601456 571 dbSNP
rs189896469 575 dbSNP
rs1290165316 578 dbSNP
rs778272702 579 dbSNP
rs1376366946 586 dbSNP
rs1293960624 588 dbSNP
rs1394905780 591 dbSNP
rs1397886525 594 dbSNP
rs770085855 613 dbSNP
rs561961958 614 dbSNP
rs1238498601 618 dbSNP
rs1360090850 624 dbSNP
rs748515974 626 dbSNP
rs542090182 627 dbSNP
rs1254444474 628 dbSNP
rs184920492 628 dbSNP
rs781604781 631 dbSNP
rs1027720402 636 dbSNP
rs556612625 642 dbSNP
rs1243739177 649 dbSNP
rs994875936 649 dbSNP
rs1461347354 650 dbSNP
rs895137644 654 dbSNP
rs1419397607 659 dbSNP
rs1033644163 675 dbSNP
rs1160873937 676 dbSNP
rs138542901 687 dbSNP
rs1465119637 689 dbSNP
rs1188962852 696 dbSNP
rs907095976 705 dbSNP
rs1445188619 706 dbSNP
rs536487037 709 dbSNP
rs1186754979 711 dbSNP
rs1010060706 714 dbSNP
rs1299486196 716 dbSNP
rs111544240 717 dbSNP
rs891571232 718 dbSNP
rs1234143652 719 dbSNP
rs1265050919 735 dbSNP
rs1250876186 746 dbSNP
rs1196695330 761 dbSNP
rs140538477 762 dbSNP
rs1054131942 764 dbSNP
rs755142540 765 dbSNP
rs751859000 766 dbSNP
rs148099183 774 dbSNP
rs746194179 778 dbSNP
rs1432228871 781 dbSNP
rs1176589826 792 dbSNP
rs921604665 799 dbSNP
rs779968813 800 dbSNP
rs577214403 813 dbSNP
rs554190797 820 dbSNP
rs1444892678 823 dbSNP
rs534294053 831 dbSNP
rs1367221974 835 dbSNP
rs568223007 838 dbSNP
rs1285374634 843 dbSNP
rs181449529 860 dbSNP
rs750340136 869 dbSNP
rs61980821 870 dbSNP
rs984046739 873 dbSNP
rs950857172 875 dbSNP
rs1206442487 881 dbSNP
rs1295022102 883 dbSNP
rs920709455 889 dbSNP
rs1382983266 890 dbSNP
rs4322591 891 dbSNP
rs569125799 897 dbSNP
rs1034116204 906 dbSNP
rs1440655430 922 dbSNP
rs1169329947 924 dbSNP
rs1420938668 929 dbSNP
rs1412103966 944 dbSNP
rs1395803762 949 dbSNP
rs1405887481 955 dbSNP
rs1003519449 956 dbSNP
rs971751084 964 dbSNP
rs1399538500 967 dbSNP
rs1270838706 985 dbSNP
rs757049616 990 dbSNP
rs1216281465 991 dbSNP
rs753668871 996 dbSNP
rs1024206554 1000 dbSNP
rs1010065065 1004 dbSNP
rs1222879132 1005 dbSNP
rs763994174 1008 dbSNP
rs552236794 1009 dbSNP
rs191073107 1014 dbSNP
rs1054185651 1023 dbSNP
rs373330620 1024 dbSNP
rs1450920654 1030 dbSNP
rs1180654558 1032 dbSNP
rs115438466 1036 dbSNP
rs766886943 1039 dbSNP
rs759059128 1040 dbSNP
rs1269307841 1043 dbSNP
rs1193994886 1049 dbSNP
rs1480305056 1050 dbSNP
rs1250798336 1053 dbSNP
rs773642597 1058 dbSNP
rs12434550 1071 dbSNP
rs770280019 1074 dbSNP
rs1419293770 1077 dbSNP
rs1039138269 1082 dbSNP
rs1347071165 1085 dbSNP
rs1344521875 1086 dbSNP
rs1445831412 1098 dbSNP
rs1282369562 1103 dbSNP
rs1381930691 1109 dbSNP
rs1246530922 1117 dbSNP
rs944368979 1119 dbSNP
rs1351120850 1123 dbSNP
rs912167316 1124 dbSNP
rs34194913 1126 dbSNP
rs1284466825 1127 dbSNP
rs1301563721 1133 dbSNP
rs1207341238 1134 dbSNP
rs1237466458 1135 dbSNP
rs1445759223 1137 dbSNP
rs1185853516 1140 dbSNP
rs1378829305 1141 dbSNP
rs1233938342 1142 dbSNP
rs1372195403 1146 dbSNP
rs1326013076 1160 dbSNP
rs546255388 1161 dbSNP
rs1333591370 1165 dbSNP
rs1047966676 1181 dbSNP
rs1396474916 1186 dbSNP
rs929508935 1192 dbSNP
rs920761826 1194 dbSNP
rs1237970582 1195 dbSNP
rs748712297 1201 dbSNP
rs1392807631 1229 dbSNP
rs1172642702 1232 dbSNP
rs1352373829 1233 dbSNP
rs76633932 1236 dbSNP
rs1261932147 1241 dbSNP
rs1462192048 1248 dbSNP
rs959458834 1261 dbSNP
rs1457611550 1271 dbSNP
rs769106679 1279 dbSNP
rs1309474056 1284 dbSNP
rs1365834707 1288 dbSNP
rs1379153273 1290 dbSNP
rs1477147054 1291 dbSNP
rs1179442541 1293 dbSNP
rs1172120151 1294 dbSNP
rs796547550 1301 dbSNP
rs1430103514 1305 dbSNP
rs186427383 1318 dbSNP
rs1178502709 1322 dbSNP
rs747161107 1324 dbSNP
rs1390660221 1328 dbSNP
rs1329289800 1333 dbSNP
rs542004382 1342 dbSNP
rs1251179750 1343 dbSNP
rs1337201349 1343 dbSNP
rs982546911 1351 dbSNP
rs1323632568 1354 dbSNP
rs1224752614 1358 dbSNP
rs1256779952 1367 dbSNP
rs143142758 1375 dbSNP
rs1196787703 1382 dbSNP
rs1484078944 1386 dbSNP
rs1253077900 1388 dbSNP
rs1450189651 1388 dbSNP
rs1024677814 1390 dbSNP
rs1269783143 1392 dbSNP
rs1210423107 1394 dbSNP
rs1481465136 1397 dbSNP
rs1010118442 1401 dbSNP
rs955931739 1404 dbSNP
rs1032819465 1409 dbSNP
rs780349469 1422 dbSNP
rs999972566 1429 dbSNP
rs1398393527 1437 dbSNP
rs900272840 1444 dbSNP
rs1308349080 1455 dbSNP
rs1345737331 1455 dbSNP
rs758496817 1463 dbSNP
rs1411069988 1464 dbSNP
rs1373085661 1477 dbSNP
rs1017348802 1485 dbSNP
rs745953300 1488 dbSNP
rs1434913165 1494 dbSNP
rs1403961918 1496 dbSNP
rs1326410580 1498 dbSNP
rs1228824103 1504 dbSNP
rs563192061 1504 dbSNP
rs1156539438 1506 dbSNP
rs1452826029 1513 dbSNP
rs890134531 1519 dbSNP
rs1222134246 1523 dbSNP
rs1364241938 1531 dbSNP
rs1047388022 1535 dbSNP
rs929564523 1536 dbSNP
rs779189459 1549 dbSNP
rs1255485159 1553 dbSNP
rs899388457 1554 dbSNP
rs1443167698 1559 dbSNP
rs1037904927 1563 dbSNP
rs1442608340 1573 dbSNP
rs1162692162 1577 dbSNP
rs757234986 1580 dbSNP
rs938145326 1583 dbSNP
rs753863751 1586 dbSNP
rs982211049 1587 dbSNP
rs949466439 1589 dbSNP
rs1339210572 1595 dbSNP
rs1245782746 1612 dbSNP
rs1281034972 1617 dbSNP
rs913907264 1619 dbSNP
rs1361923396 1624 dbSNP
rs1350429988 1630 dbSNP
rs1260321569 1634 dbSNP
rs1269228035 1646 dbSNP
rs181866026 1658 dbSNP
rs1206960987 1669 dbSNP
rs1459902917 1671 dbSNP
rs988072105 1690 dbSNP
rs1385663076 1701 dbSNP
rs1446190893 1708 dbSNP
rs1354163568 1710 dbSNP
rs1362804610 1717 dbSNP
rs1453917345 1719 dbSNP
rs1290107724 1722 dbSNP
rs1452517255 1729 dbSNP
rs1337908685 1731 dbSNP
rs1385475785 1734 dbSNP
rs955983724 1740 dbSNP
rs1306575526 1741 dbSNP
rs1317740517 1746 dbSNP
rs1241329195 1748 dbSNP
rs1254310130 1761 dbSNP
rs1032871935 1762 dbSNP
rs763753456 1763 dbSNP
rs1243613712 1768 dbSNP
rs964566321 1775 dbSNP
rs1175250305 1776 dbSNP
rs1249459168 1778 dbSNP
rs1414887845 1791 dbSNP
rs1017821080 1793 dbSNP
rs1008649345 1794 dbSNP
rs890177435 1795 dbSNP
rs1399836698 1799 dbSNP
rs755958141 1803 dbSNP
rs1468795034 1811 dbSNP
rs778963599 1812 dbSNP
rs1385383560 1818 dbSNP
rs755272063 1821 dbSNP
rs1408866198 1829 dbSNP
rs1161186773 1832 dbSNP
rs1440549464 1834 dbSNP
rs1297933074 1835 dbSNP
rs1459790036 1835 dbSNP
rs554043879 1837 dbSNP
rs1025999879 1849 dbSNP
rs1393383893 1867 dbSNP
rs546640069 1873 dbSNP
rs899439390 1874 dbSNP
rs528042703 1878 dbSNP
rs1263746002 1892 dbSNP
rs938214648 1898 dbSNP
rs905370861 1899 dbSNP
rs1250524754 1900 dbSNP
rs1480807340 1902 dbSNP
rs1191289064 1909 dbSNP
rs1446712103 1911 dbSNP
rs1266242042 1913 dbSNP
rs1479831497 1923 dbSNP
rs1199491709 1932 dbSNP
rs3742771 1941 dbSNP
rs759250187 1954 dbSNP
rs1211020330 1959 dbSNP
rs1333261521 1964 dbSNP
rs1355514829 1964 dbSNP
rs949508259 1966 dbSNP
rs1345109601 1986 dbSNP
rs1228325347 1987 dbSNP
rs549051107 1994 dbSNP
rs1347371114 1996 dbSNP
rs1212755015 2009 dbSNP
rs1272152381 2010 dbSNP
rs139112411 2011 dbSNP
rs1206283592 2028 dbSNP
rs1289220904 2032 dbSNP
rs1429586109 2037 dbSNP
rs988122948 2042 dbSNP
rs530661252 2043 dbSNP
rs1201784006 2044 dbSNP
rs1474119194 2045 dbSNP
rs1186453642 2048 dbSNP
rs925905863 2058 dbSNP
rs1430727723 2075 dbSNP
rs1162058042 2084 dbSNP
rs1365225664 2096 dbSNP
rs1425509514 2107 dbSNP
rs796093610 2110 dbSNP
rs978655851 2118 dbSNP
rs1438481200 2121 dbSNP
rs763952756 2122 dbSNP
rs765923461 2127 dbSNP
rs538037051 2142 dbSNP
rs1430023409 2143 dbSNP
rs1269531445 2146 dbSNP
rs56151550 2159 dbSNP
rs1390692820 2173 dbSNP
rs45485696 2188 dbSNP
rs1230422300 2189 dbSNP
rs1312616396 2191 dbSNP
rs1358403367 2202 dbSNP
rs1246301302 2203 dbSNP
rs777227081 2204 dbSNP
rs1444797112 2205 dbSNP
rs189041726 2209 dbSNP
rs954515249 2216 dbSNP
rs1026051689 2218 dbSNP
rs538575091 2230 dbSNP
rs1385026429 2233 dbSNP
rs566434912 2234 dbSNP
rs1015905373 2235 dbSNP
rs963035069 2235 dbSNP
rs796885769 2237 dbSNP
rs1002464995 2239 dbSNP
rs1345765454 2240 dbSNP
rs1437217057 2240 dbSNP
rs116667369 2260 dbSNP
rs1252853986 2262 dbSNP
rs1381776552 2277 dbSNP
rs1246368899 2286 dbSNP
rs1046587220 2289 dbSNP
rs1222930583 2298 dbSNP
rs1348099543 2299 dbSNP
rs1014150711 2301 dbSNP
rs1284315595 2309 dbSNP
rs1330540641 2315 dbSNP
rs1202358561 2321 dbSNP
rs1242998676 2325 dbSNP
rs892588467 2336 dbSNP
rs1270234909 2351 dbSNP
rs185112174 2362 dbSNP
rs878988697 2369 dbSNP
rs936723853 2371 dbSNP
rs1410298248 2378 dbSNP
rs533081940 2382 dbSNP
rs925289202 2387 dbSNP
rs181765387 2390 dbSNP
rs1453192959 2399 dbSNP
rs1369965672 2408 dbSNP
rs1333667091 2409 dbSNP
rs1441048771 2417 dbSNP
rs1279726153 2426 dbSNP
rs1293967151 2430 dbSNP
rs13099 2433 dbSNP
rs1352744475 2435 dbSNP
rs1202593126 2449 dbSNP
rs1271352222 2452 dbSNP
rs116193864 2459 dbSNP
rs1429217558 2465 dbSNP
rs1371323747 2469 dbSNP
rs1234763384 2475 dbSNP
rs1170726985 2476 dbSNP
rs1479532262 2477 dbSNP
rs910447730 2477 dbSNP
rs1428560207 2479 dbSNP
rs1394850736 2483 dbSNP
rs1470231081 2486 dbSNP
rs868100741 2487 dbSNP
rs374365959 2488 dbSNP
rs1329147446 2489 dbSNP
rs1339152768 2489 dbSNP
rs1409090451 2489 dbSNP
rs56846554 2489 dbSNP
rs754185900 2489 dbSNP
rs1196730036 2490 dbSNP
rs1221900567 2490 dbSNP
rs1491565969 2490 dbSNP
rs758389538 2490 dbSNP
rs201642324 2491 dbSNP
rs954699344 2491 dbSNP
rs1254676567 2492 dbSNP
rs919043153 2492 dbSNP
rs878938158 2493 dbSNP
rs963087317 2493 dbSNP
rs1191623422 2494 dbSNP
rs562950123 2494 dbSNP
rs1015957645 2495 dbSNP
rs1446326013 2495 dbSNP
rs1459051633 2496 dbSNP
rs546439046 2496 dbSNP
rs1383286881 2497 dbSNP
rs1384932342 2497 dbSNP
rs1381049774 2498 dbSNP
rs1452304507 2498 dbSNP
rs1013784850 2499 dbSNP
rs570350143 2499 dbSNP
rs372177676 2500 dbSNP
rs1404523952 2501 dbSNP
rs1467962663 2501 dbSNP
rs35138830 2501 dbSNP
rs796492629 2501 dbSNP
rs1306510844 2502 dbSNP
rs1381683595 2502 dbSNP
rs1491523847 2502 dbSNP
rs557026392 2502 dbSNP
rs1203127679 2503 dbSNP
rs1230288157 2503 dbSNP
rs892642977 2504 dbSNP
rs1270010077 2505 dbSNP
rs1052513302 2518 dbSNP
rs1000923488 2519 dbSNP
rs1256387787 2520 dbSNP
rs1484086973 2531 dbSNP
rs1175129145 2533 dbSNP
rs1249317312 2536 dbSNP
rs560792987 2549 dbSNP
rs1183713011 2553 dbSNP
rs1208276012 2554 dbSNP
rs1346757648 2565 dbSNP
rs1177364377 2575 dbSNP
rs1301697974 2582 dbSNP
rs772422627 2584 dbSNP
rs1460734214 2589 dbSNP
rs1297878065 2591 dbSNP
rs1220764828 2592 dbSNP
rs1371034874 2593 dbSNP
rs572893883 2598 dbSNP
rs1411786441 2600 dbSNP
rs942678311 2607 dbSNP
rs776916763 2610 dbSNP
rs1344906182 2611 dbSNP
rs188310914 2614 dbSNP
rs910509338 2615 dbSNP
rs757441226 2620 dbSNP
rs1052108731 2621 dbSNP
rs368544598 2628 dbSNP
rs1310005435 2630 dbSNP
rs1206743429 2631 dbSNP
rs1266181058 2636 dbSNP
rs765812880 2637 dbSNP
rs866161295 2641 dbSNP
rs1427850778 2643 dbSNP
rs574934887 2643 dbSNP
rs1170148351 2650 dbSNP
rs1177193531 2660 dbSNP
rs919097011 2670 dbSNP
rs971869185 2671 dbSNP
rs1365036784 2672 dbSNP
rs777778025 2677 dbSNP
rs963137819 2685 dbSNP
rs908941798 2687 dbSNP
rs1369640165 2692 dbSNP
rs1416524180 2699 dbSNP
rs1406352439 2700 dbSNP
rs1342549945 2707 dbSNP
rs868480655 2708 dbSNP
rs1289056578 2718 dbSNP
rs1251234414 2721 dbSNP
rs1473245416 2725 dbSNP
rs969450013 2729 dbSNP
rs1024607243 2733 dbSNP
rs760550057 2734 dbSNP
rs1186392951 2738 dbSNP
rs956929788 2740 dbSNP
rs555056640 2744 dbSNP
rs1249066451 2748 dbSNP
rs71426997 2749 dbSNP
rs1451643498 2757 dbSNP
rs1031141182 2758 dbSNP
rs544391696 2759 dbSNP
rs1406095812 2760 dbSNP
rs1485115004 2762 dbSNP
rs575364991 2764 dbSNP
rs1428581554 2768 dbSNP
rs1319762663 2774 dbSNP
rs1256255493 2791 dbSNP
rs1436937699 2804 dbSNP
rs1355170941 2805 dbSNP
rs1228442824 2808 dbSNP
rs538635042 2812 dbSNP
rs1314569538 2819 dbSNP
rs1215708007 2821 dbSNP
rs771340664 2822 dbSNP
rs1466573011 2825 dbSNP
rs1182133493 2829 dbSNP
rs1018772993 2830 dbSNP
rs558494700 2832 dbSNP
rs1006927251 2837 dbSNP
rs1183769486 2841 dbSNP
rs184163369 2844 dbSNP
rs1196454876 2846 dbSNP
rs1400123505 2847 dbSNP
rs1228925140 2848 dbSNP
rs1051068033 2862 dbSNP
rs1389280164 2864 dbSNP
rs1458654527 2875 dbSNP
rs192952024 2884 dbSNP
rs1290266516 2890 dbSNP
rs897718347 2897 dbSNP
rs1285519972 2899 dbSNP
rs1269400843 2901 dbSNP
rs1331804975 2906 dbSNP
rs552892014 2910 dbSNP
rs747489707 2919 dbSNP
rs1278392200 2926 dbSNP
rs1378631981 2935 dbSNP
rs1212519785 2940 dbSNP
rs1036227629 2941 dbSNP
rs1303658965 2942 dbSNP
rs369561389 2943 dbSNP
rs546885280 2943 dbSNP
rs1182949673 2944 dbSNP
rs1412681250 2946 dbSNP
rs908994623 2949 dbSNP
rs1158946035 2950 dbSNP
rs1458211928 2955 dbSNP
rs1174128968 2960 dbSNP
rs543085509 2961 dbSNP
rs1414763338 2965 dbSNP
rs1162128063 2966 dbSNP
rs1422728226 2985 dbSNP
rs1352392881 2987 dbSNP
rs566925273 2988 dbSNP
rs1288409931 2989 dbSNP
rs1351750114 2990 dbSNP
rs1222256884 2992 dbSNP
rs1183222365 2993 dbSNP
rs1346167561 2999 dbSNP
rs1484726033 3010 dbSNP
rs145988207 3011 dbSNP
rs991755769 3015 dbSNP
rs575781888 3019 dbSNP
rs1206075053 3021 dbSNP
rs1254108759 3029 dbSNP
rs1331070372 3038 dbSNP
rs1376983787 3039 dbSNP
rs748310175 3039 dbSNP
rs979610318 3044 dbSNP
rs765837371 3047 dbSNP
rs371798733 3048 dbSNP
rs1428734744 3051 dbSNP
rs1308221205 3059 dbSNP
rs1371875218 3063 dbSNP
rs1402491961 3064 dbSNP
rs1323550059 3066 dbSNP
rs1313619420 3071 dbSNP
rs368408860 3075 dbSNP
rs1235950357 3089 dbSNP
rs1007390849 3090 dbSNP
rs1341848265 3093 dbSNP
rs1360201173 3095 dbSNP
rs188088142 3096 dbSNP
rs1357441083 3100 dbSNP
rs1030091192 3103 dbSNP
rs1266632022 3107 dbSNP
rs1452089369 3124 dbSNP
rs994156936 3126 dbSNP
rs1246001194 3129 dbSNP
rs1436323367 3148 dbSNP
rs1391378252 3155 dbSNP
rs569402188 3156 dbSNP
rs1036271700 3161 dbSNP
rs1391620569 3165 dbSNP
rs941891001 3169 dbSNP
rs1162103277 3170 dbSNP
rs887607722 3178 dbSNP
rs1426345069 3180 dbSNP
rs1316773426 3183 dbSNP
rs1364937455 3188 dbSNP
rs1389191141 3195 dbSNP
rs1300178102 3209 dbSNP
rs1357508283 3211 dbSNP
rs1244222156 3214 dbSNP
rs552470311 3224 dbSNP
rs1266135578 3226 dbSNP
rs1358516508 3230 dbSNP
rs1211574886 3237 dbSNP
rs1266105468 3239 dbSNP
rs1464320535 3245 dbSNP
rs1188967797 3253 dbSNP
rs1188921676 3265 dbSNP
rs1249552601 3266 dbSNP
rs1421709120 3270 dbSNP
rs1044880649 3276 dbSNP
rs1368545614 3277 dbSNP
rs1458941845 3279 dbSNP
rs1157393941 3280 dbSNP
rs1466097993 3286 dbSNP
rs754244279 3289 dbSNP
rs947809183 3290 dbSNP
rs1322941271 3292 dbSNP
rs1395704154 3294 dbSNP
rs561231298 3294 dbSNP
rs879667792 3294 dbSNP
rs917661332 3299 dbSNP
rs1342361315 3300 dbSNP
rs1488790558 3304 dbSNP
rs991809157 3316 dbSNP
rs1328352004 3320 dbSNP
rs1247116338 3322 dbSNP
rs1305950273 3324 dbSNP
rs934995868 3327 dbSNP
rs15156 3329 dbSNP
rs1297153509 3330 dbSNP
rs1229516006 3331 dbSNP
rs1425103284 3335 dbSNP
rs924230206 3338 dbSNP
rs15157 3341 dbSNP
rs979661171 3352 dbSNP
rs1473219379 3354 dbSNP
rs1161955529 3371 dbSNP
rs968290231 3379 dbSNP
rs1465807850 3388 dbSNP
rs1303702803 3399 dbSNP
rs911400821 3402 dbSNP
rs1392139952 3403 dbSNP
rs1389789312 3409 dbSNP
rs1294723756 3415 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
65 hsa-miR-539-3p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT102192 NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 2 4
MIRT147308 KPNA2 karyopherin subunit alpha 2 2 8
MIRT255970 WDR17 WD repeat domain 17 2 2
MIRT318225 RREB1 ras responsive element binding protein 1 2 4
MIRT339123 ARID1A AT-rich interaction domain 1A 2 2
MIRT341161 HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 2 2
MIRT439452 TMED10 transmembrane p24 trafficking protein 10 1 1
MIRT439861 PTPRS protein tyrosine phosphatase, receptor type S 1 1
MIRT440178 MTRNR2L8 MT-RNR2-like 8 1 1
MIRT440188 MTRNR2L2 MT-RNR2-like 2 1 1
MIRT440445 INTS3 integrator complex subunit 3 1 1
MIRT440771 DST dystonin 1 1
MIRT440838 DDX17 DEAD-box helicase 17 1 1
MIRT440928 CLTC clathrin heavy chain 1 1
MIRT441017 CANX calnexin 1 1
MIRT441020 CAND1 cullin associated and neddylation dissociated 1 1 1
MIRT441272 ACTR3C ARP3 actin related protein 3 homolog C 1 1
MIRT441275 ACTR3B ARP3 actin related protein 3 homolog B 1 1
MIRT446564 IDS iduronate 2-sulfatase 2 2
MIRT458674 MRI1 methylthioribose-1-phosphate isomerase 1 2 2
MIRT467486 SMIM13 small integral membrane protein 13 2 2
MIRT471515 PCGF3 polycomb group ring finger 3 2 6
MIRT488211 TESK2 testis-specific kinase 2 2 6
MIRT505413 TCF7L2 transcription factor 7 like 2 2 4
MIRT506405 NRF1 nuclear respiratory factor 1 2 4
MIRT508095 ANKRD33B ankyrin repeat domain 33B 2 4
MIRT511883 GAS1 growth arrest specific 1 2 6
MIRT513413 RTP4 receptor transporter protein 4 2 2
MIRT515814 FOCAD focadhesin 2 2
MIRT522747 LNPEP leucyl and cystinyl aminopeptidase 2 2
MIRT526664 IL5RA interleukin 5 receptor subunit alpha 2 6
MIRT532113 G6PC glucose-6-phosphatase catalytic subunit 2 2
MIRT547536 MAML3 mastermind like transcriptional coactivator 3 2 2
MIRT554605 RPS6KA5 ribosomal protein S6 kinase A5 2 2
MIRT554884 RCAN2 regulator of calcineurin 2 2 2
MIRT555859 PANK3 pantothenate kinase 3 2 2
MIRT556601 LDOC1L retrotransposon Gag like 6 2 4
MIRT565169 LINC00598 long intergenic non-protein coding RNA 598 2 2
MIRT567099 KANSL1 KAT8 regulatory NSL complex subunit 1 2 2
MIRT575032 Fasl Fas ligand (TNF superfamily, member 6) 1 1
MIRT609327 TAS2R30 taste 2 receptor member 30 2 4
MIRT609394 C11orf74 chromosome 11 open reading frame 74 2 2
MIRT613120 SRCAP Snf2 related CREBBP activator protein 2 2
MIRT614273 WSCD2 WSC domain containing 2 2 2
MIRT614988 GID4 GID complex subunit 4 homolog 2 4
MIRT619483 QSOX2 quiescin sulfhydryl oxidase 2 2 2
MIRT622061 SS18 SS18, nBAF chromatin remodeling complex subunit 2 2
MIRT627045 HOXA13 homeobox A13 2 2
MIRT657273 HS3ST3B1 heparan sulfate-glucosamine 3-sulfotransferase 3B1 2 2
MIRT658285 FASLG Fas ligand 2 3
MIRT660838 AGO3 argonaute 3, RISC catalytic component 2 2
MIRT665552 UCHL5 ubiquitin C-terminal hydrolase L5 2 2
MIRT687560 MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 2 2
MIRT698864 SRSF2 serine and arginine rich splicing factor 2 2 2
MIRT699509 SKIL SKI like proto-oncogene 2 2
MIRT706255 MKLN1 muskelin 1 2 2
MIRT711973 HOMER2 homer scaffolding protein 2 2 2
MIRT718038 NIPAL2 NIPA like domain containing 2 2 2
MIRT718766 ABHD15 abhydrolase domain containing 15 2 2
MIRT721319 GRHL1 grainyhead like transcription factor 1 2 2
MIRT721439 NGDN neuroguidin 2 2
MIRT721977 RAD50 RAD50 double strand break repair protein 2 2
MIRT725374 MTF2 metal response element binding transcription factor 2 2 2
MIRT737461 CTBP1 C-terminal binding protein 1 4 0
MIRT755390 Sox9 SRY-box 9 4 1
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-539 Budesonide approved 5281004 Microarray neonatal mice liver 20145010 2010 up-regulated
miR-539 17beta-estradiol (E2) approved 5757 Microarray rat breast 17700064 2007 down-regulated
miR-539 Dexamethasone approved 5743 Microarray primary rat thymocytes 20847043 2010 up-regulated
miR-539 Longevinex NULL NULL Quantitative real-time PCR ischemia/reperfusion [I/R] rat model 21203465 2011 up-regulated
miR-539 Resveratrol NULL 445154 Quantitative real-time PCR ischemia/reperfusion [I/R] rat model 21203465 2011 down-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-539 Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-mir-539 Fluorouracil 3385 NSC19893 approved resistant cell line (OE19)
hsa-mir-539 Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-539-3p Ceritinib 57379345 NSC776422 approved resistant High Non-Small Cell Lung Cancer cell line (H3122, H2228)
hsa-miR-539-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-539-3p Osimertinib 71496458 NSC779217 approved sensitive cell line (HCC827)
hsa-miR-539-3p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-539-3p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-539-3p Ceritinib 57379345 NSC776422 approved resistant cell line (H3122)
hsa-miR-539-3p Docetaxel+Cisplatin+5-Fluorouracil resistant tissue (hypopharyngeal squamous cell carcinoma)

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