miRTarBase - #MIRT439525


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pre-miRNA Information
pre-miRNA hsa-mir-127   
Genomic Coordinates chr14: 100882979 - 100883075
Description Homo sapiens miR-127 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-127-5p
Sequence 23| CUGAAGCUCAGAGGGCUCUGAU |44
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM9722115 13 COSMIC
COSM7115045 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs867796380 11 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol STBD1   
Synonyms GENEX3414, GENX-3414
Description starch binding domain 1
Transcript NM_003943   
Expression
Putative miRNA Targets on STBD1
3'UTR of STBD1
(miRNA target sites are highlighted)		 
>STBD1|NM_003943|3'UTR
   1 TTCAGTTTGCAAAGTAATGGAGAAGCTGTAGAACAATGTGGAAGAGGCTGAGGTTGTGGAACACACTGAATAAAATAAAG
  81 GCAGTGTGACTCCAAATTCAGCCATCTGAATTGTTTAAATTTGCTAGTGGATTTTGTCTAATGTGCAGAAATATATATGT
 161 CTAATGTGCAGAAATATATATGTGTGTATGTGTGTATATATATGCACACACACACAGATAATGCTTCCAGTGAATGTGAA
 241 CTTCTTTTCCCTGTGGCACTGATTGACAGACTTGTGCTGATCCATTATTACTTTAGGGCTTGATTCTCTTGGGGAGTGAC
 321 TTGGCTAAGCTTCAGGTGTAAACTGTGGTCACGGAGCAAAAACATTAACCAGCTGCCCAGGGTTCAAGCTTGAGCCTTTA
 401 GGTGATCTTTAAACTATGGTAGTAAAATAAGCCTCACTCAAACATAGCTGACTTCCTATTGGTACAGCTTGAAAAGCACT
 481 TTTTACTACATACACATTTTATGCTTAAAAAGTTAACATGATACGAAACTGTGATTAGAAAATATCTGGTCTGGATGTGA
 561 TTAGTAAGGATACAAGATAATGTTCTAAGACTGCCTAATGCTTTTTGTTTGATTTTCATCTGCCAGGCGTTGTTATGTGC
 641 TATGAGGGTAGCAAGTACGTCTTTGTCTTAATGATCTAAGGCTGGTGTAGAAACAAAGGGCCTAATGAGAACCAATCATC
 721 ATGGAAGTCAGTTGCGGGGGCAGCCCATAAGGAAAGGGAAAGTGAGTGGGGTTGGGCATAGGCTGAGTGAGGTGGCCTGA
 801 ATGACACCTCTTAGAGGACTGTGAAGTACAGGCACAGCCCGACTGCAGGGAGGGATGCACCCATCATTTACCCATGGGAG
 881 CATCTGTAGGACCATCTCTCTCCCACTTCTTCTCCCCTCCCCCACCGCATCTGGCCAGATGGACTGTCCTACAGCAATCG
 961 TTTCCATCTGTCACCCTCTTCCCTCTCCTTTCATACCAGTCACTATCTTGGGTAACAAATTTATACAGGACAGTGGTACA
1041 GAAATACATCTTTGCTCTGAGAATACAGCAAATATTAACTTAAATTATTATAACTGAACAAATAATAAAACCTGAATTTT
1121 AATATCTTCAAAAAAAAAAAAAA
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uagUCUCGGGA--GACUCGAAGUc 5'
             || | |:|  || ||||||| 
Target 5' gggAGTGACTTGGCTAAGCTTCAg 3'
 312 - 335 157.00 -16.20
2 
miRNA  3' uaguCUCGGGAG---ACUCGAAGUc 5'
              |||||:|:   ||| |||:| 
Target 5' gcttGAGCCTTTAGGTGATCTTTAa 3'
 388 - 412 122.00 -12.40
3 
miRNA  3' uaGUCUCG------GGA-GAC----UCGAAGUc 5'
            || |||      ||| :||    ||||| | 
Target 5' aaCATAGCTGACTTCCTATTGGTACAGCTTGAa 3'
 441 - 473 116.00 -12.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30112568 3 COSMIC
COSN31564121 10 COSMIC
COSN23457287 20 COSMIC
COSN31527599 83 COSMIC
COSN30110268 85 COSMIC
COSN31479987 100 COSMIC
COSN26975861 108 COSMIC
COSN31490642 109 COSMIC
COSN30509680 128 COSMIC
COSN30523102 128 COSMIC
COSN18729083 194 COSMIC
COSN23328415 206 COSMIC
COSN31535813 216 COSMIC
COSN1301219 254 COSMIC
COSN1301221 325 COSMIC
COSN26553410 405 COSMIC
COSN26604275 494 COSMIC
COSN28649383 651 COSMIC
COSN29261232 677 COSMIC
COSN2044936 705 COSMIC
COSN31483052 786 COSMIC
COSN30538579 899 COSMIC
COSN30538582 916 COSMIC
COSN7843343 1012 COSMIC
COSN9241739 1093 COSMIC
rs115137643 979 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs1488063748 3 dbSNP
rs547751435 8 dbSNP
rs767757004 9 dbSNP
rs1263479179 10 dbSNP
rs1229289599 22 dbSNP
rs1451514332 22 dbSNP
rs370864822 23 dbSNP
rs1277113390 27 dbSNP
rs1419132514 30 dbSNP
rs1216317014 31 dbSNP
rs1424439413 35 dbSNP
rs1167088254 37 dbSNP
rs1348631261 38 dbSNP
rs1441240193 39 dbSNP
rs747375638 53 dbSNP
rs1304321082 58 dbSNP
rs1386680650 61 dbSNP
rs1011612560 66 dbSNP
rs1449917283 69 dbSNP
rs762746357 82 dbSNP
rs944226141 91 dbSNP
rs903146000 96 dbSNP
rs770641747 114 dbSNP
rs1462752756 127 dbSNP
rs1399920467 130 dbSNP
rs3733248 142 dbSNP
rs80159369 143 dbSNP
rs1356332854 144 dbSNP
rs1036156394 146 dbSNP
rs1481485008 151 dbSNP
rs1430053530 155 dbSNP
rs1198191570 156 dbSNP
rs1232829002 159 dbSNP
rs958921905 165 dbSNP
rs35491311 172 dbSNP
rs1265098695 174 dbSNP
rs1197350111 176 dbSNP
rs759064730 177 dbSNP
rs1013484887 179 dbSNP
rs1458034616 179 dbSNP
rs1257107106 183 dbSNP
rs930230520 187 dbSNP
rs1048518418 193 dbSNP
rs1309774086 195 dbSNP
rs1329859508 195 dbSNP
rs888149015 195 dbSNP
rs1352864352 196 dbSNP
rs1329621687 200 dbSNP
rs1001685665 205 dbSNP
rs1224433758 205 dbSNP
rs1302853975 208 dbSNP
rs1407061952 217 dbSNP
rs1284139988 221 dbSNP
rs17001770 228 dbSNP
rs1375915333 230 dbSNP
rs1183898130 245 dbSNP
rs1440123988 257 dbSNP
rs752119580 263 dbSNP
rs1176489320 265 dbSNP
rs963592807 269 dbSNP
rs1462397601 272 dbSNP
rs552155717 274 dbSNP
rs1199398224 279 dbSNP
rs1342260181 289 dbSNP
rs1263060302 291 dbSNP
rs1241482773 299 dbSNP
rs1485553827 304 dbSNP
rs1014011011 305 dbSNP
rs868550669 310 dbSNP
rs1376754389 324 dbSNP
rs1307572217 336 dbSNP
rs146780391 339 dbSNP
rs951015775 344 dbSNP
rs372696915 353 dbSNP
rs548920990 354 dbSNP
rs554776482 362 dbSNP
rs942571629 373 dbSNP
rs1160276888 379 dbSNP
rs185780874 382 dbSNP
rs754340555 383 dbSNP
rs189338437 386 dbSNP
rs534030542 389 dbSNP
rs1032743054 394 dbSNP
rs1156615230 411 dbSNP
rs914528869 415 dbSNP
rs757701080 417 dbSNP
rs1436575886 419 dbSNP
rs958097305 421 dbSNP
rs985945290 422 dbSNP
rs1440250747 423 dbSNP
rs112760770 429 dbSNP
rs1041622523 431 dbSNP
rs903196878 433 dbSNP
rs965461620 435 dbSNP
rs1284432274 442 dbSNP
rs976894683 448 dbSNP
rs918783199 453 dbSNP
rs17001772 459 dbSNP
rs1412721992 465 dbSNP
rs1057239583 468 dbSNP
rs894537040 491 dbSNP
rs1048675615 495 dbSNP
rs1337792217 504 dbSNP
rs7671037 507 dbSNP
rs1442986503 508 dbSNP
rs1298911941 518 dbSNP
rs577118529 525 dbSNP
rs181717881 526 dbSNP
rs1296251860 531 dbSNP
rs1055878417 536 dbSNP
rs1414229409 549 dbSNP
rs1237061374 553 dbSNP
rs1471626318 558 dbSNP
rs556527746 558 dbSNP
rs750705231 567 dbSNP
rs1193770415 576 dbSNP
rs993721129 581 dbSNP
rs1026496983 582 dbSNP
rs1261739768 586 dbSNP
rs576092074 593 dbSNP
rs1281685839 594 dbSNP
rs951071120 595 dbSNP
rs1347550375 598 dbSNP
rs1209221291 604 dbSNP
rs986854587 616 dbSNP
rs1019388912 621 dbSNP
rs751170882 621 dbSNP
rs767430894 621 dbSNP
rs1279007041 626 dbSNP
rs541939055 630 dbSNP
rs1338484685 637 dbSNP
rs758515763 639 dbSNP
rs1438555133 645 dbSNP
rs1350362705 648 dbSNP
rs140532969 651 dbSNP
rs1230608307 653 dbSNP
rs780245242 659 dbSNP
rs1455201438 660 dbSNP
rs914397435 676 dbSNP
rs1032968740 677 dbSNP
rs747042936 679 dbSNP
rs1006858568 687 dbSNP
rs1018305528 696 dbSNP
rs1246564209 700 dbSNP
rs369660250 702 dbSNP
rs1394432786 713 dbSNP
rs965435476 722 dbSNP
rs1259019445 723 dbSNP
rs1198228239 728 dbSNP
rs976863519 731 dbSNP
rs768660731 732 dbSNP
rs527862088 736 dbSNP
rs541650284 737 dbSNP
rs1057439243 739 dbSNP
rs1274168678 742 dbSNP
rs1434117705 744 dbSNP
rs754819803 753 dbSNP
rs778994439 761 dbSNP
rs144849069 769 dbSNP
rs1328445858 771 dbSNP
rs1334000658 773 dbSNP
rs1397624595 780 dbSNP
rs1177604546 783 dbSNP
rs1278265619 796 dbSNP
rs1443229100 798 dbSNP
rs910103106 801 dbSNP
rs948815795 805 dbSNP
rs777688704 809 dbSNP
rs1471390648 824 dbSNP
rs533688978 839 dbSNP
rs1232523424 841 dbSNP
rs1037759198 842 dbSNP
rs1456617394 843 dbSNP
rs1265167992 859 dbSNP
rs899355413 872 dbSNP
rs1210985317 876 dbSNP
rs138652084 886 dbSNP
rs1277881629 888 dbSNP
rs13680 891 dbSNP
rs1355703675 902 dbSNP
rs949789273 906 dbSNP
rs148864645 910 dbSNP
rs1445681279 913 dbSNP
rs770738020 917 dbSNP
rs1194816757 918 dbSNP
rs1374211951 924 dbSNP
rs548293824 926 dbSNP
rs568204620 927 dbSNP
rs533747185 928 dbSNP
rs1019697388 934 dbSNP
rs547570218 935 dbSNP
rs77487079 936 dbSNP
rs975581875 952 dbSNP
rs1422097409 953 dbSNP
rs558044061 954 dbSNP
rs1373369460 960 dbSNP
rs759275261 961 dbSNP
rs1021360568 966 dbSNP
rs1258614983 976 dbSNP
rs115137643 979 dbSNP
rs1167511504 982 dbSNP
rs1018275845 983 dbSNP
rs1398416605 994 dbSNP
rs1217991159 1004 dbSNP
rs901209190 1008 dbSNP
rs998269893 1023 dbSNP
rs1463051225 1027 dbSNP
rs1351223151 1036 dbSNP
rs1314477265 1037 dbSNP
rs1228557399 1040 dbSNP
rs1377943068 1055 dbSNP
rs1326724284 1061 dbSNP
rs977239093 1068 dbSNP
rs12548 1073 dbSNP
rs747467515 1075 dbSNP
rs1298119827 1085 dbSNP
rs1418299775 1106 dbSNP
rs1370543485 1107 dbSNP
rs1165865614 1117 dbSNP
rs768048002 1125 dbSNP
rs960224145 1131 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE28260 Renal cortex and medulla -0.805 4.5e-4 -0.659 7.1e-3 13 Click to see details
GSE21687 Ependynoma primary tumors -0.182 7.5e-2 -0.235 3.1e-2 64 Click to see details
GSE28544 Breast cancer -0.262 1.1e-1 -0.128 2.8e-1 24 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.203 2.0e-1 -0.150 2.6e-1 20 Click to see details
GSE32688 Pancreatic cancer -0.13 2.4e-1 -0.088 3.2e-1 32 Click to see details
GSE38226 Liver fibrosis 0.117 3.1e-1 0.149 2.6e-1 21 Click to see details
GSE19536 Breast cancer 0.036 3.6e-1 0.037 3.6e-1 100 Click to see details
GSE17498 Multiple myeloma 0.058 3.6e-1 0.127 2.2e-1 40 Click to see details
GSE26953 Aortic valvular endothelial cells -0.047 4.1e-1 0.076 3.6e-1 24 Click to see details
GSE19350 CNS germ cell tumors -0.07 4.1e-1 -0.024 4.7e-1 12 Click to see details
GSE19783 ER+ ER+ breast cancer 0.042 4.3e-1 -0.057 4.1e-1 20 Click to see details
GSE42095 Differentiated embryonic stem cells 0.032 4.4e-1 0.017 4.7e-1 23 Click to see details
GSE19783 ER- ER- breast cancer -0.015 4.5e-1 -0.017 4.4e-1 79 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.015 4.7e-1 0.204 1.6e-1 25 Click to see details
GSE38974 Chronic obstructive pulmonary disease -0.015 4.7e-1 0.204 1.6e-1 25 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
LUSC -0.362 0.01 -0.371 0.01 38 Click to see details
THCA 0.254 0.03 0.370 0 59 Click to see details
HNSC 0.235 0.07 0.262 0.05 42 Click to see details
STAD -0.264 0.07 -0.165 0.18 32 Click to see details
PRAD -0.203 0.08 -0.058 0.34 50 Click to see details
BRCA -0.11 0.16 -0.076 0.25 84 Click to see details
PAAD 0.533 0.23 0.800 0.1 4 Click to see details
KIRP -0.125 0.25 -0.045 0.4 32 Click to see details
UCEC -0.145 0.28 -0.221 0.18 19 Click to see details
PCPG 0.579 0.3 0.500 0.33 3 Click to see details
LUAD -0.148 0.32 -0.203 0.26 12 Click to see details
BLCA -0.11 0.33 -0.077 0.38 18 Click to see details
CESC -0.287 0.41 -0.500 0.33 3 Click to see details
ESCA -0.062 0.43 0.000 0.5 11 Click to see details
COAD -0.074 0.43 -0.048 0.46 8 Click to see details
CHOL 0.041 0.46 -0.100 0.4 9 Click to see details
KICH -0.017 0.47 -0.076 0.36 25 Click to see details
LIHC 0.009 0.48 -0.019 0.45 49 Click to see details
KIRC 0.006 0.48 -0.059 0.32 68 Click to see details
KIRC 0.006 0.48 -0.059 0.32 68 Click to see details
KIRC 0.006 0.48 -0.059 0.32 68 Click to see details
113 hsa-miR-127-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT380928 ZNF264 zinc finger protein 264 2 2
MIRT439324 USP34 ubiquitin specific peptidase 34 1 1
MIRT439333 USP22 ubiquitin specific peptidase 22 1 1
MIRT439379 TTC37 tetratricopeptide repeat domain 37 1 1
MIRT439445 TMEM116 transmembrane protein 116 1 1
MIRT439498 SYNJ2 synaptojanin 2 1 1
MIRT439525 STBD1 starch binding domain 1 1 1
MIRT439562 SORL1 sortilin related receptor 1 1 1
MIRT439660 SF3B1 splicing factor 3b subunit 1 1 1
MIRT439749 ROGDI rogdi homolog 1 1
MIRT439836 RAB3B RAB3B, member RAS oncogene family 1 1
MIRT439923 PPL periplakin 1 1
MIRT439963 PKD1 polycystin 1, transient receptor potential channel interacting 1 1
MIRT439985 PHKG2 phosphorylase kinase catalytic subunit gamma 2 1 1
MIRT440029 PCLO piccolo presynaptic cytomatrix protein 1 1
MIRT440179 MTRNR2L8 MT-RNR2-like 8 1 1
MIRT440183 MTRNR2L4 MT-RNR2-like 4 1 1
MIRT440184 MTRNR2L6 MT-RNR2-like 6 1 1
MIRT440194 MTRNR2L1 MT-RNR2-like 1 1 1
MIRT440269 MBP myelin basic protein 1 1
MIRT440323 LIN7C lin-7 homolog C, crumbs cell polarity complex component 1 1
MIRT440331 LGALS8 galectin 8 1 1
MIRT440355 KLHL29 kelch like family member 29 1 1
MIRT440397 KDM6B lysine demethylase 6B 1 1
MIRT440411 KAT2B lysine acetyltransferase 2B 1 1
MIRT440424 ITCH itchy E3 ubiquitin protein ligase 1 1
MIRT440651 FBXO7 F-box protein 7 1 1
MIRT440773 DST dystonin 1 1
MIRT440824 DGKD diacylglycerol kinase delta 1 1
MIRT440914 COPA coatomer protein complex subunit alpha 1 1
MIRT441118 BBS4 Bardet-Biedl syndrome 4 1 1
MIRT441153 ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 1 1
MIRT441193 ARID1A AT-rich interaction domain 1A 1 1
MIRT441260 ADM adrenomedullin 1 1
MIRT441282 ACTB actin beta 1 1
MIRT441306 ABHD2 abhydrolase domain containing 2 1 1
MIRT441860 TEX35 testis expressed 35 2 2
MIRT442190 CCDC132 VPS50, EARP/GARPII complex subunit 2 2
MIRT442886 RHCG Rh family C glycoprotein 2 2
MIRT444158 ZNF701 zinc finger protein 701 2 2
MIRT444506 ZNF525 zinc finger protein 525 2 2
MIRT444770 NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 2 2
MIRT445830 SRSF11 serine and arginine rich splicing factor 11 2 2
MIRT445850 LRRC1 leucine rich repeat containing 1 2 2
MIRT445863 ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2 2
MIRT446161 C8A complement C8 alpha chain 2 2
MIRT447117 SLFN5 schlafen family member 5 2 2
MIRT447990 CDX1 caudal type homeobox 1 2 2
MIRT449032 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 2 2
MIRT449295 SMIM19 small integral membrane protein 19 2 2
MIRT449541 PCDH9 protocadherin 9 2 2
MIRT449579 ZNF510 zinc finger protein 510 2 2
MIRT450062 SYT9 synaptotagmin 9 2 2
MIRT450437 CAPZA1 capping actin protein of muscle Z-line alpha subunit 1 2 2
MIRT450449 ZDHHC2 zinc finger DHHC-type containing 2 2 2
MIRT450695 RORA RAR related orphan receptor A 2 2
MIRT453654 RAB6C RAB6C, member RAS oncogene family 2 2
MIRT463771 YOD1 YOD1 deubiquitinase 2 2
MIRT468425 SETD1B SET domain containing 1B 2 2
MIRT468843 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT475594 HMGB2 high mobility group box 2 4 4
MIRT478284 DDX19A DEAD-box helicase 19A 2 2
MIRT487594 NKD2 naked cuticle homolog 2 2 4
MIRT493440 KANSL1 KAT8 regulatory NSL complex subunit 1 2 6
MIRT496169 RPL35A ribosomal protein L35a 2 4
MIRT497566 CCR6 C-C motif chemokine receptor 6 2 2
MIRT497917 BTG1 BTG anti-proliferation factor 1 2 2
MIRT498331 PRELID2 PRELI domain containing 2 2 2
MIRT498369 KLHL11 kelch like family member 11 2 2
MIRT498856 LITAF lipopolysaccharide induced TNF factor 2 2
MIRT505640 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT506128 PLRG1 pleiotropic regulator 1 2 4
MIRT512242 ARPP19 cAMP regulated phosphoprotein 19 2 4
MIRT512489 ARID2 AT-rich interaction domain 2 2 2
MIRT525251 RNF213 ring finger protein 213 2 2
MIRT530197 ALX1 ALX homeobox 1 2 4
MIRT530551 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT534048 STC2 stanniocalcin 2 2 2
MIRT537508 FAM105A family with sequence similarity 105 member A 2 2
MIRT543005 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT543814 SNX10 sorting nexin 10 2 2
MIRT549303 ARID5B AT-rich interaction domain 5B 2 2
MIRT549407 ADIPOR2 adiponectin receptor 2 2 4
MIRT550547 ARSK arylsulfatase family member K 2 2
MIRT554319 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT554515 RUFY2 RUN and FYVE domain containing 2 2 2
MIRT559603 AMOT angiomotin 2 2
MIRT564844 ZBED3 zinc finger BED-type containing 3 2 2
MIRT566125 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT567484 FOXK1 forkhead box K1 2 2
MIRT576521 Txlna taxilin alpha 2 2
MIRT633635 CASC5 kinetochore scaffold 1 2 2
MIRT639325 C9orf41 carnosine N-methyltransferase 1 2 2
MIRT643174 MDM2 MDM2 proto-oncogene 2 2
MIRT651214 ZNF225 zinc finger protein 225 2 2
MIRT653039 STRIP2 striatin interacting protein 2 2 2
MIRT653042 STOX2 storkhead box 2 2 2
MIRT658769 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT666728 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT681223 DUSP19 dual specificity phosphatase 19 2 2
MIRT685562 SRD5A3 steroid 5 alpha-reductase 3 2 2
MIRT687434 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT688439 DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 2 2
MIRT692707 MEAF6 MYST/Esa1 associated factor 6 2 2
MIRT700552 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT704955 CBX2 chromobox 2 2 2
MIRT714524 ALKBH3 alkB homolog 3, alpha-ketoglutaratedependent dioxygenase 2 2
MIRT716225 DGKI diacylglycerol kinase iota 2 2
MIRT717953 MIA3 MIA family member 3, ER export factor 2 2
MIRT719902 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT732044 BLVRB biliverdin reductase B 3 1
MIRT733622 SNX5 sorting nexin 5 3 0
MIRT737210 CXCR4 C-X-C motif chemokine receptor 4 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-127 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR rat breast 17700064 2007 down-regulated
miR-127 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) NULL NULL Microarray T24 human bladder cancer cells 16766263 2006 up-regulated
miR-127 17beta-estradiol (E2) approved 5757 Microarray rat breast 17700064 2007 down-regulated
miR-127-5p Glucose NULL 5793 Microarray endothelial cells 24394957 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-127 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-mir-127 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-miR-127-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-127-5p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM11)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-127-5p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-127-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-127-5p Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR200)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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