miRTarBase - #MIRT439562


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pre-miRNA Information
pre-miRNA hsa-mir-127   
Genomic Coordinates chr14: 100882979 - 100883075
Description Homo sapiens miR-127 stem-loop
Comment This miRNA sequence is predicted based on homology to a verified miRNA from mouse .
RNA Secondary Structure
Associated Diseases

Mature miRNA Information
Mature miRNA hsa-miR-127-5p
Sequence 23| CUGAAGCUCAGAGGGCUCUGAU |44
Evidence Experimental
Experiments Cloned
DRVs in miRNA
Mutant ID Mutant Position Mutant Source
COSM9722115 13 COSMIC
COSM7115045 18 COSMIC
SNPs in miRNA
Mutant ID Mutant Position Mutant Source
rs867796380 11 dbSNP
Putative Targets

miRNA Expression profile
Human miRNA Tissue Atlas
miRNAs in Extracellular Vesicles
Circulating MicroRNA Expression Profiling
Gene Information
Gene Symbol SORL1   
Synonyms C11orf32, LR11, LRP9, SORLA, SorLA-1, gp250
Description sortilin related receptor 1
Transcript NM_003105   
Expression
Putative miRNA Targets on SORL1
3'UTR of SORL1
(miRNA target sites are highlighted)		 
>SORL1|NM_003105|3'UTR
   1 AAGAGCTTTCCTCACTAGAAACCAAATGGTGTAAATATTTTATTTGATAAAGATAGTTGATGGTTTATTTTAAAAGATGC
  81 ACTTTGAGTTGCAATATGTTATTTTTATATGGGCCAAAAACAAAAAACAAAAAAAAAAAAAAGGAAAGAAAGGAATGAAT
 161 AAACTTTGTAGTAATCAACTGTGAACTTCAAACCAGGTTGATTTTAGTAACCCAATTGCTTTGATTTGACATTAATGTAG
 241 TCTTACAGGGCTGTGCTTGCTGGGCATGCTTTTACGTCTGTGAGATAATTTCGGTTCAGTAAATTGGCCAATCTTTTTAT
 321 TTTTCTAAGACACAGAAATGTATTTAATAAAAACCTCGAGAGAGTGATGGGTGGAACCCCTTCTCCTTGAAAGTGTGTAC
 401 AGATATTCCATTTTGTTTGGATATAGTTTATAGGAAAGTGTGTGGATGTATTATGGCGGAAGGTTTCTTTATGTTATTTT
 481 GTTAATTTATTGGGACTCTGTGTAAGGCCAGGCTTTAGTGGTCATTAGACACCACATGTGTTATGAGCCCCTTACCCATA
 561 GGGTTGGGGGTGGGAAGAGAAGCATATTTTTTTGCCATTCCGGAAGCAATCCATTTTTATTCACTTGTGTGTCATGTAAT
 641 GGTCTTTGGCAGGAGAGAGCACTGAGTCATTGCTGGAGTTCAGTTCAACAGAGCTGCAGCTTGGGAAGCCCTGTAAGCCC
 721 ACAGCTTCCTCTCTTATATTAATTGATGGAATTTTACTGTATGTGCCTCTGTACAAGATGTAGCTTTGAGAGCTACAAAA
 801 TGATAACACTGCTTTATTACACACTGGTTTCATTGTCATTGCAAAAACTTACCCTGGTTGTGGGGGAGAGTTCTAGATCT
 881 GTGCCATGATCCATACACTGGCTAATAGAGTACATAATTTTTCCATTTTCCATTTTTTGTTTTTACTTACTACTGAAGGA
 961 TCTCAGATGTAAAATTATGTATTTGGTTTGAGATGGCCACTTATTGTCCTTAAAAATCCATACTGATATATGCAGTCATT
1041 TTGAATTGGACAGTGCCTTCTCTTTTTTTTTCTCCTCTTCTTCCATCTCCCTCACCCATGCCCCCACCCAATCTAAAGAG
1121 ACAGTGCTGTACATTCTCATAGAGATAGAGAAGATCTAAAAAGTTGAGACTACTCAATCCAGTTAACAACAGCAGGAGCA
1201 CTAGAGTTTGTTCATTTATTCTCTCTGTAAAACAAGCTGTGCTTTTTTTCTTCTGCCTTTAAAATGCCACCCGTGTATTC
1281 AAACCATGGCCACTTGATACTTATGTAGAATCCATCGTGGGCTGATGCAAGCCCTTTATTTAGGCTTAGTGTTGTGGGCA
1361 CCAATGTCGAGCATCGTTGTGACTTGTGCTGTATGATTCTCACTGAAGAATTTCCTTTCAGCCAAGAAGCAGTGAGGTCT
1441 GGGAATATTCCAAAGTCATGTCTCTGAATATGTGTCCTTGACGTGCAAGCTTTGTAAAACCCCATCCCCGCTTAGGTGCG
1521 AGGCATCACCTTCTCACAAGTGTTTAGTTTCTTTTAACCACAAGTATCATTCTTGGGTGATAATATAGTTTCATTCTACT
1601 TAGGGATTGTTTAGAAAACAAAGAAAGAGCCAATTAAATTTTTTAGTTTTTGAAATTTTTATTTATATGTATACTTAGAT
1681 GAGTATTTTAAGCTGTCGACCTTTAGTTTGCCATACGGGTAGGACTGTATTTCATGTTAACAACTGGTGGTAATGATAAG
1761 CCTTCTTCTAGCGTATTTTCTCTTCTTTCCTGTCACTTTCCTAAGTTTTTTTTTTTAAAGACTGGAATTTTTTTTGGCTT
1841 TATCTTGTCTTACCGTAGAGATTTGTTCAAAACTCTAAGCCCTACCACCTCCCCTTTAATAAGCTCTTTAAATAGTTGAA
1921 TCATTAACAACCTGGTGGGAGGCAAGTCATTTAATTGAACCACTAGGAAGTGTATTTTCTTTTCTTTTTCTGCCAACTTT
2001 TTGGTGGCATTTGTAAAAGCTGATATAAAAGGCTCTGAGATGTTATTTTCAGTTATTCCATAGGCAAGCCTTTTTACAGA
2081 GCATATGTCTCCAGTTGGCAGCTTGAGATATTTCCGAGCATCCGGTTCTAGCTACCAGTGCCTCCCAATGCTTAGTGCAC
2161 AGTACTGTAGACTGGCCATCACCCCTCTCCTTGGAAAATGCCACTGTGCTGTTTGAAAAAAAGCAGCCTTTTAGGGCTAG
2241 AGTATTTTATATAAACAGAAGAGCTAAGTTCCTGAAGACTAAGCTAGATAGCTGCAGCTATATGTAAATTGTATATTTTT
2321 ATGAACTTTTGAAGCACACACTCCTGTTTCCCTCTGTGTAGCTTTGTGGGGATTTCATGTATATATGCTGTCTGAAAGAA
2401 TCCAGAGGTTGGAGTGCCAATAGAAAATGAAAACAAATGCCTTGTACTACAGGCAGCCTCTGAAGGTGACCACATAACTG
2481 TCTTCACTGTGACCAATCGGAGTCCCTGCTTGCTTGTGAAGAAGGGGCTTTTGTACCTTGTTGGAGATGCCACCTCAGAA
2561 GTTCACACTGTGCAGGAAAAAGGTTTTATTCTCTCCTGGCATACATTAGAATGTCAGATGCTTGCATCCATGTGGACCAC
2641 GATGGGCCTCTAAAAATTGGTGGGCAGGGGGTTTGCTTATGAGTTTTCTCTGGAAACCGATTTTACTCCTGGATGTATTG
2721 AATGCCCCTTGAGCTTTATGAGATACGAGTCCACATGGATAAAATGTTAGAGAGTGGAGTTCTACAGAGGATTCCAGGAA
2801 GAGGCCATGTCTGTGCAGTCCTAGTTCCAGACAGGTGAGAAGCTCCAGGAACTACTGGCTACCTTGACAAGCTGGGTAAA
2881 TAGTTATCATTCTGGGTAACTGGTTGAAACTCTGACTTTTGGACAAGTAATTCCTGGGGTTCTGTCTTTGGTAGCATCAC
2961 CAGGGATATTTGGGTGGGACAGACAGAAGACACACAGCTGCCTGTTCTCTCCTGCCCATCATGTTTGGCCCACTAGATGA
3041 AGCTGTACTCAGCAATTTAGGGAATGTAACCCTTCTCAGAACTGGCCATTTTCAGGGGAAGCTTGGGAGAGCAATAGTAT
3121 GGTGAGCCCCTTAGAGATGAGCGCCTACTCCTTCTTGGCGAATGCTGCCTTCAGATGCTTACCAAGTGGTCACTGCATCT
3201 AGTAAGATTATATTTCCAGTACACTTCCTTAGGGCAGAAACACCATCCTATCAGGTTTGGTCAGTCCCTTCTTCATGAAG
3281 GGAGTCATGGGGAATTCCTGAAAATTTTCTTCCTTCTGCAGACAGTTGGATGAGTCCCTTAGAGAAGGCATCCAGAGACA
3361 TAACTAAACTGAATATCATCCCATATTGATTTTAGGAATTGACTCTAAAACTCTGTGCAGAATCTTGTGTTGGGATTGTA
3441 TCTTGACATTCCTGTTGTGTTATTTTTCTTAACTGGAGTGTGTGCTGCCTTTCAGGTACAATTTTTGTGTAATAAAAGCC
3521 AGTGCATTAAGTTTATATAGACTACTTTCTATGCAAGACTGAGATATGGAATAGATAGGAAGAGATATGTACTGCTGGGT
3601 ACATGGACAGTAAGTGTGTTTTCAGATGGAGTACCAGCACCGAAAATGGGTTGAGGGAGGATGGGTTGTATGTATGTTTC
3681 TGCCCACTAATTTTGAGCAGCCATATTATGAATTAAATCGTCACAGCCAAGTAATAACCCAAGAATGGTATGAGTTTCAT
3761 GTGTAATAGCTCAAATGGAATAAGCATGAATGCTGGAGTGGACCATTATCCTCAAATATTCTATGTCACTTCTCATTTAA
3841 AGACTCTTGTTATGAACTATTAGAAACTTTAGGCAAAATCAAAAGTATTTGCGGCAAAATAAAGGCCTATTCTACTCTTA
3921 TTTAAAGTGAAACACTGTATACTTGTTTCTCTCCAAAGCGAAATTAAGTATTTATAATTTCAATTGCCTCGATAAGTTTC
4001 CAAGTCACTGAAATCTGCTGAAGGTTTTACTGTATTGTTGCACAACTTTAAGATAATTTTTGTCTCAATGTCAACTTTTT
4081 TCACTGAATAAAAATTTAACTGGGTCAAGAAAACACCTCTTTGAAAATCCACTGTCTCTGTGTGTCTCGAGCTGTTCTTT
4161 AGAGCGCAATAAAGATGGCTGACGCAGTCTCCAAACCCC
Target sites Provided by authors   Predicted by miRanda    DRVs    SNPs    DRVs & SNPs
miRNA-target interactions
(Predicted by miRanda)
ID Duplex structure Position Score MFE
1 
miRNA  3' uagucuCGGGAGACUCGAAGUc 5'
                |||| :|||||||:| 
Target 5' ttgaatGCCCCTTGAGCTTTAt 3'
 2718 - 2739 152.00 -18.70
2 
miRNA  3' uagUCUCGGGAGACUCGAAGUc 5'
             ||| :  | ||||:|||| 
Target 5' ccaAGAATGGTATGAGTTTCAt 3'
 3739 - 3760 143.00 -10.20
3 
miRNA  3' uagucUCGGGAGACUCGAAGuc 5'
               ||||| |  ||||||  
Target 5' ctgtaAGCCCAC--AGCTTCct 3'
 711 - 730 137.00 -12.70
DRVs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
COSN30533706 14 COSMIC
COSN31512828 18 COSMIC
COSN31583168 41 COSMIC
COSN30466221 63 COSMIC
COSN24381463 64 COSMIC
COSN30178450 77 COSMIC
COSN30508260 81 COSMIC
COSN28562355 99 COSMIC
COSN20056605 122 COSMIC
COSN28636655 129 COSMIC
COSN32049960 142 COSMIC
COSN20108927 143 COSMIC
COSN30528596 143 COSMIC
COSN31529074 149 COSMIC
COSN10079429 614 COSMIC
COSN16381081 796 COSMIC
COSN6607396 870 COSMIC
COSN31778858 1491 COSMIC
COSN25021950 1711 COSMIC
COSN514701 1801 COSMIC
COSN20108928 1803 COSMIC
COSN15663240 1804 COSMIC
COSN27202258 1817 COSMIC
COSN15075056 1901 COSMIC
COSN23745067 1939 COSMIC
COSN30028169 2024 COSMIC
COSN1516497 2107 COSMIC
COSN25158316 2380 COSMIC
COSN8939517 2850 COSMIC
COSN17535261 3320 COSMIC
COSN25560498 3364 COSMIC
COSN21984744 3450 COSMIC
COSN30415278 3630 COSMIC
COSN30408976 3631 COSMIC
COSN30302829 3721 COSMIC
COSN20092439 3847 COSMIC
COSN1516498 3888 COSMIC
rs10790449 1135 GWAS
SNPs in gene 3'UTRs
Mutant ID Mutant Position Mutant Source
rs752807243 13 dbSNP
rs1217447294 15 dbSNP
rs760698596 17 dbSNP
rs765174280 20 dbSNP
rs750294614 23 dbSNP
rs758198317 24 dbSNP
rs1301614835 29 dbSNP
rs1458957502 32 dbSNP
rs1234213576 39 dbSNP
rs1256303260 41 dbSNP
rs779888938 44 dbSNP
rs1176731173 49 dbSNP
rs751223058 52 dbSNP
rs1297341947 55 dbSNP
rs1304018588 76 dbSNP
rs780468417 81 dbSNP
rs1165293892 82 dbSNP
rs1289704396 93 dbSNP
rs921764854 95 dbSNP
rs1373410132 97 dbSNP
rs542388938 107 dbSNP
rs931778268 110 dbSNP
rs1396855482 113 dbSNP
rs1433114828 115 dbSNP
rs1190907737 116 dbSNP
rs1427430156 116 dbSNP
rs1261762563 120 dbSNP
rs12287461 121 dbSNP
rs1273327157 121 dbSNP
rs1484450551 122 dbSNP
rs879178512 122 dbSNP
rs1210673517 128 dbSNP
rs7129474 128 dbSNP
rs1296317757 129 dbSNP
rs566582399 129 dbSNP
rs73020651 129 dbSNP
rs879101080 129 dbSNP
rs1401910068 130 dbSNP
rs1353873101 133 dbSNP
rs552625587 136 dbSNP
rs1415220586 137 dbSNP
rs1376996935 140 dbSNP
rs1282648587 143 dbSNP
rs911783847 144 dbSNP
rs1361489540 145 dbSNP
rs1352137774 151 dbSNP
rs1004160596 153 dbSNP
rs1373162533 156 dbSNP
rs1171970592 158 dbSNP
rs184853682 160 dbSNP
rs1256432762 168 dbSNP
rs1188165489 179 dbSNP
rs1486223099 184 dbSNP
rs899202263 186 dbSNP
rs769051240 188 dbSNP
rs1029045275 195 dbSNP
rs528291617 199 dbSNP
rs1220588107 211 dbSNP
rs987633956 216 dbSNP
rs1019545598 221 dbSNP
rs1292931792 230 dbSNP
rs895338954 246 dbSNP
rs1342044906 254 dbSNP
rs1326540244 260 dbSNP
rs189323512 268 dbSNP
rs988378199 276 dbSNP
rs1025255723 277 dbSNP
rs914908107 279 dbSNP
rs1437720329 281 dbSNP
rs1165204838 285 dbSNP
rs946349242 293 dbSNP
rs775361675 294 dbSNP
rs1361693572 299 dbSNP
rs1180190658 301 dbSNP
rs181735329 308 dbSNP
rs1360883625 312 dbSNP
rs1251930846 314 dbSNP
rs926368113 320 dbSNP
rs1402252526 330 dbSNP
rs1467219416 331 dbSNP
rs75085036 350 dbSNP
rs1214566062 353 dbSNP
rs1056287450 358 dbSNP
rs886963728 359 dbSNP
rs1238108562 367 dbSNP
rs1437532747 370 dbSNP
rs1336081670 372 dbSNP
rs780250868 373 dbSNP
rs1305698237 374 dbSNP
rs939915602 375 dbSNP
rs536439200 381 dbSNP
rs1393118640 386 dbSNP
rs1326066560 392 dbSNP
rs1240007741 397 dbSNP
rs1310657762 398 dbSNP
rs1353219547 403 dbSNP
rs78371549 416 dbSNP
rs1289697335 419 dbSNP
rs1469967106 420 dbSNP
rs898424546 427 dbSNP
rs1381266799 436 dbSNP
rs770043308 453 dbSNP
rs566235165 458 dbSNP
rs1029427894 459 dbSNP
rs533616940 464 dbSNP
rs889179325 475 dbSNP
rs1213984106 477 dbSNP
rs987283417 490 dbSNP
rs558148315 492 dbSNP
rs1204737139 499 dbSNP
rs967690576 501 dbSNP
rs923943168 502 dbSNP
rs1370242047 513 dbSNP
rs1019094870 519 dbSNP
rs1438049641 521 dbSNP
rs1324122216 522 dbSNP
rs1317237013 531 dbSNP
rs1400858852 534 dbSNP
rs956911116 537 dbSNP
rs759338688 546 dbSNP
rs868772184 551 dbSNP
rs1433240864 558 dbSNP
rs148594688 559 dbSNP
rs76031328 560 dbSNP
rs968287740 563 dbSNP
rs948247699 566 dbSNP
rs1192767150 569 dbSNP
rs980374116 571 dbSNP
rs926309845 573 dbSNP
rs939097007 578 dbSNP
rs767513635 586 dbSNP
rs1406143766 587 dbSNP
rs1483207563 594 dbSNP
rs556813849 597 dbSNP
rs114248842 602 dbSNP
rs17337209 603 dbSNP
rs1336884734 614 dbSNP
rs1269018847 621 dbSNP
rs1430805257 626 dbSNP
rs1342057289 632 dbSNP
rs1036591644 636 dbSNP
rs898391902 642 dbSNP
rs17125569 649 dbSNP
rs1375182872 650 dbSNP
rs1177438490 651 dbSNP
rs994490432 653 dbSNP
rs1417979953 656 dbSNP
rs1167478557 674 dbSNP
rs1478172372 675 dbSNP
rs1332555676 677 dbSNP
rs1265678509 694 dbSNP
rs1028769050 698 dbSNP
rs1485239963 700 dbSNP
rs1237770857 704 dbSNP
rs572588052 705 dbSNP
rs1212167195 711 dbSNP
rs1338043589 715 dbSNP
rs538736461 718 dbSNP
rs1436066934 723 dbSNP
rs752553262 724 dbSNP
rs1214686074 725 dbSNP
rs575279992 726 dbSNP
rs1291078935 728 dbSNP
rs751854871 731 dbSNP
rs75210260 759 dbSNP
rs1355244029 760 dbSNP
rs1450631775 767 dbSNP
rs1019204982 768 dbSNP
rs1357539182 773 dbSNP
rs7951423 790 dbSNP
rs753818844 825 dbSNP
rs531727067 834 dbSNP
rs1163057908 840 dbSNP
rs1274684721 842 dbSNP
rs1474970112 849 dbSNP
rs1414780346 854 dbSNP
rs550639410 859 dbSNP
rs1009666689 863 dbSNP
rs1197456259 866 dbSNP
rs1468378844 893 dbSNP
rs757134308 909 dbSNP
rs958061589 914 dbSNP
rs1250689304 915 dbSNP
rs1270672625 918 dbSNP
rs1439472915 928 dbSNP
rs1212509455 933 dbSNP
rs1322023539 945 dbSNP
rs1314397733 950 dbSNP
rs10892762 967 dbSNP
rs1371568742 973 dbSNP
rs529889029 980 dbSNP
rs548007442 982 dbSNP
rs1402563748 989 dbSNP
rs968257428 994 dbSNP
rs1324031976 998 dbSNP
rs917741306 1001 dbSNP
rs1350722378 1004 dbSNP
rs12276187 1009 dbSNP
rs1331694940 1017 dbSNP
rs117097913 1021 dbSNP
rs991847544 1031 dbSNP
rs908253307 1043 dbSNP
rs1046436592 1045 dbSNP
rs1251061555 1047 dbSNP
rs928140886 1063 dbSNP
rs940839224 1063 dbSNP
rs1037048730 1072 dbSNP
rs551835586 1073 dbSNP
rs1465360740 1075 dbSNP
rs1171456806 1076 dbSNP
rs1398785769 1078 dbSNP
rs1394765363 1081 dbSNP
rs1315511541 1082 dbSNP
rs1334120935 1093 dbSNP
rs570401088 1099 dbSNP
rs779629210 1101 dbSNP
rs1301839529 1106 dbSNP
rs899395142 1112 dbSNP
rs961134666 1114 dbSNP
rs1341395462 1128 dbSNP
rs10790449 1135 dbSNP
rs919789007 1139 dbSNP
rs1050078458 1140 dbSNP
rs1315670761 1154 dbSNP
rs932540434 1157 dbSNP
rs1050148073 1164 dbSNP
rs1421259179 1167 dbSNP
rs1393248462 1176 dbSNP
rs1172883885 1178 dbSNP
rs888748150 1181 dbSNP
rs1251353166 1183 dbSNP
rs1268756308 1191 dbSNP
rs910546654 1193 dbSNP
rs1009067399 1199 dbSNP
rs1485373506 1205 dbSNP
rs1263448207 1208 dbSNP
rs944663475 1243 dbSNP
rs1340902512 1250 dbSNP
rs1356265901 1252 dbSNP
rs189324007 1273 dbSNP
rs575080530 1274 dbSNP
rs1312850136 1278 dbSNP
rs1009633953 1279 dbSNP
rs1380602333 1293 dbSNP
rs536121407 1304 dbSNP
rs554440536 1305 dbSNP
rs904069540 1311 dbSNP
rs1401640478 1316 dbSNP
rs1002450600 1317 dbSNP
rs572654938 1318 dbSNP
rs528996625 1327 dbSNP
rs1032915930 1332 dbSNP
rs1034312473 1335 dbSNP
rs1427376059 1347 dbSNP
rs1374820995 1349 dbSNP
rs113244743 1350 dbSNP
rs1172444609 1351 dbSNP
rs778790280 1352 dbSNP
rs143035724 1354 dbSNP
rs1195329341 1356 dbSNP
rs770385867 1365 dbSNP
rs1015282042 1367 dbSNP
rs564593260 1369 dbSNP
rs773432663 1376 dbSNP
rs868249457 1377 dbSNP
rs928057251 1380 dbSNP
rs1225404603 1382 dbSNP
rs1317323142 1386 dbSNP
rs576416960 1394 dbSNP
rs919757948 1396 dbSNP
rs1220626578 1430 dbSNP
rs543800454 1431 dbSNP
rs1333330149 1433 dbSNP
rs561902844 1438 dbSNP
rs749272535 1440 dbSNP
rs954050070 1451 dbSNP
rs985320447 1455 dbSNP
rs145952593 1459 dbSNP
rs943981769 1460 dbSNP
rs1172376493 1472 dbSNP
rs1348486596 1478 dbSNP
rs139807088 1483 dbSNP
rs1133174 1484 dbSNP
rs1353728911 1509 dbSNP
rs888805276 1510 dbSNP
rs945461136 1511 dbSNP
rs1235438362 1520 dbSNP
rs143120634 1521 dbSNP
rs1258908145 1530 dbSNP
rs1194544582 1536 dbSNP
rs1457374297 1539 dbSNP
rs903954614 1541 dbSNP
rs938139319 1543 dbSNP
rs1055317100 1548 dbSNP
rs577712391 1556 dbSNP
rs1431442396 1562 dbSNP
rs1333047384 1567 dbSNP
rs1198239905 1593 dbSNP
rs1283784068 1597 dbSNP
rs1395823318 1600 dbSNP
rs1245306264 1603 dbSNP
rs896702236 1605 dbSNP
rs1013866257 1606 dbSNP
rs1015252548 1607 dbSNP
rs376144741 1620 dbSNP
rs564924 1621 dbSNP
rs581498 1633 dbSNP
rs1157417218 1634 dbSNP
rs1445865673 1635 dbSNP
rs1360234488 1645 dbSNP
rs1454648515 1647 dbSNP
rs1332856283 1648 dbSNP
rs896866345 1649 dbSNP
rs1289022665 1654 dbSNP
rs1386682535 1658 dbSNP
rs1384779096 1666 dbSNP
rs1163432438 1668 dbSNP
rs544767726 1670 dbSNP
rs1370497579 1673 dbSNP
rs999135739 1690 dbSNP
rs1026703201 1696 dbSNP
rs1239312583 1697 dbSNP
rs570537659 1698 dbSNP
rs985667535 1699 dbSNP
rs531262906 1702 dbSNP
rs1307015884 1706 dbSNP
rs181355179 1709 dbSNP
rs1239138156 1714 dbSNP
rs563355444 1717 dbSNP
rs575133836 1718 dbSNP
rs568047774 1722 dbSNP
rs1262336552 1726 dbSNP
rs913896684 1727 dbSNP
rs536182785 1730 dbSNP
rs763895362 1735 dbSNP
rs979403072 1742 dbSNP
rs1253661438 1746 dbSNP
rs1382311479 1758 dbSNP
rs925336411 1763 dbSNP
rs938123197 1766 dbSNP
rs1469895698 1772 dbSNP
rs554501835 1773 dbSNP
rs776366564 1774 dbSNP
rs74631598 1775 dbSNP
rs1420277122 1780 dbSNP
rs765098928 1789 dbSNP
rs982116113 1794 dbSNP
rs1161719924 1796 dbSNP
rs148947240 1797 dbSNP
rs200544054 1802 dbSNP
rs397802334 1802 dbSNP
rs56828381 1802 dbSNP
rs1456030623 1803 dbSNP
rs370511631 1804 dbSNP
rs373251351 1805 dbSNP
rs1035552360 1806 dbSNP
rs1231913028 1806 dbSNP
rs1324835781 1810 dbSNP
rs897421060 1818 dbSNP
rs962143495 1820 dbSNP
rs972106393 1822 dbSNP
rs186425606 1823 dbSNP
rs1413202071 1828 dbSNP
rs1425061555 1828 dbSNP
rs920761693 1828 dbSNP
rs1329139201 1829 dbSNP
rs1384958897 1836 dbSNP
rs1372520041 1837 dbSNP
rs1391951430 1838 dbSNP
rs1308842177 1839 dbSNP
rs1026662446 1841 dbSNP
rs889518240 1843 dbSNP
rs1244274154 1845 dbSNP
rs1006662530 1848 dbSNP
rs757912056 1849 dbSNP
rs1336959290 1851 dbSNP
rs1196829452 1853 dbSNP
rs965274420 1855 dbSNP
rs988612647 1856 dbSNP
rs1020118133 1874 dbSNP
rs1441837941 1876 dbSNP
rs910796266 1876 dbSNP
rs1279208658 1881 dbSNP
rs191728357 1886 dbSNP
rs1040038101 1891 dbSNP
rs1277214034 1895 dbSNP
rs146702048 1904 dbSNP
rs1341531116 1907 dbSNP
rs1423615667 1914 dbSNP
rs925337588 1915 dbSNP
rs938077371 1917 dbSNP
rs1446269611 1921 dbSNP
rs528355215 1926 dbSNP
rs934435719 1964 dbSNP
rs1054109125 1971 dbSNP
rs990961198 1973 dbSNP
rs1226054730 1987 dbSNP
rs918072962 1992 dbSNP
rs544681679 1993 dbSNP
rs1442785887 1995 dbSNP
rs139075555 1997 dbSNP
rs181790958 2008 dbSNP
rs918811298 2013 dbSNP
rs1376625398 2024 dbSNP
rs1472329705 2025 dbSNP
rs1238005910 2027 dbSNP
rs1212098889 2028 dbSNP
rs1012689617 2044 dbSNP
rs931580061 2046 dbSNP
rs1044313910 2059 dbSNP
rs1357594414 2060 dbSNP
rs1217091143 2061 dbSNP
rs573677850 2062 dbSNP
rs1319638993 2063 dbSNP
rs541771146 2070 dbSNP
rs1226990715 2080 dbSNP
rs1003985011 2083 dbSNP
rs1048515381 2084 dbSNP
rs1450746884 2096 dbSNP
rs1207175874 2099 dbSNP
rs962313576 2109 dbSNP
rs889498036 2116 dbSNP
rs1027713935 2117 dbSNP
rs1007042393 2123 dbSNP
rs952221906 2125 dbSNP
rs986282309 2149 dbSNP
rs1404582980 2166 dbSNP
rs1191106070 2168 dbSNP
rs546417082 2179 dbSNP
rs1437809422 2183 dbSNP
rs1410055942 2186 dbSNP
rs1237487754 2210 dbSNP
rs560006560 2212 dbSNP
rs1220292162 2216 dbSNP
rs1263346252 2216 dbSNP
rs976707592 2221 dbSNP
rs900920889 2228 dbSNP
rs1352204184 2233 dbSNP
rs1309145899 2235 dbSNP
rs375348541 2238 dbSNP
rs934298473 2240 dbSNP
rs527542967 2252 dbSNP
rs914304775 2253 dbSNP
rs1435955243 2257 dbSNP
rs1313242313 2261 dbSNP
rs1350668346 2285 dbSNP
rs1166735372 2293 dbSNP
rs1377089160 2301 dbSNP
rs1398336827 2304 dbSNP
rs545981702 2323 dbSNP
rs948594845 2331 dbSNP
rs1020088839 2335 dbSNP
rs968593075 2338 dbSNP
rs1000093497 2342 dbSNP
rs1032754692 2351 dbSNP
rs959437024 2367 dbSNP
rs1269849706 2378 dbSNP
rs991237034 2382 dbSNP
rs747302208 2389 dbSNP
rs970822790 2392 dbSNP
rs1248063207 2408 dbSNP
rs972880716 2409 dbSNP
rs1002792935 2414 dbSNP
rs1285965894 2421 dbSNP
rs1241423690 2422 dbSNP
rs1318827278 2435 dbSNP
rs754611073 2435 dbSNP
rs1037331215 2449 dbSNP
rs564098142 2450 dbSNP
rs531469489 2452 dbSNP
rs781714676 2453 dbSNP
rs1295480697 2457 dbSNP
rs1282864823 2459 dbSNP
rs1359590536 2461 dbSNP
rs1296629066 2466 dbSNP
rs1298750290 2467 dbSNP
rs1421505861 2469 dbSNP
rs1131497 2474 dbSNP
rs1048672801 2481 dbSNP
rs3087925 2497 dbSNP
rs1426859171 2499 dbSNP
rs550807996 2500 dbSNP
rs1262843530 2501 dbSNP
rs1041126390 2509 dbSNP
rs1017779133 2525 dbSNP
rs372091547 2537 dbSNP
rs966572483 2551 dbSNP
rs1209567053 2553 dbSNP
rs900903019 2554 dbSNP
rs1312797326 2555 dbSNP
rs762631176 2557 dbSNP
rs186587775 2569 dbSNP
rs1422509184 2575 dbSNP
rs1453696052 2576 dbSNP
rs1174216345 2582 dbSNP
rs547374543 2589 dbSNP
rs376943054 2595 dbSNP
rs1400045913 2596 dbSNP
rs749768742 2597 dbSNP
rs1041514812 2600 dbSNP
rs1360321759 2606 dbSNP
rs1376995828 2614 dbSNP
rs569288426 2620 dbSNP
rs904405381 2622 dbSNP
rs1131499 2623 dbSNP
rs1194897591 2629 dbSNP
rs914355400 2632 dbSNP
rs1034237972 2644 dbSNP
rs958877944 2652 dbSNP
rs1181746335 2660 dbSNP
rs558343995 2666 dbSNP
rs1346005550 2668 dbSNP
rs1433225680 2669 dbSNP
rs1012228267 2672 dbSNP
rs1025423066 2680 dbSNP
rs570137510 2682 dbSNP
rs928504804 2699 dbSNP
rs80038008 2709 dbSNP
rs1338446915 2714 dbSNP
rs1351878604 2716 dbSNP
rs1311930150 2725 dbSNP
rs1396474173 2726 dbSNP
rs1384885517 2727 dbSNP
rs972849655 2732 dbSNP
rs1464620473 2735 dbSNP
rs1285468104 2745 dbSNP
rs773686555 2750 dbSNP
rs1447197431 2755 dbSNP
rs1025808334 2757 dbSNP
rs952821933 2758 dbSNP
rs1467654522 2760 dbSNP
rs1367027730 2767 dbSNP
rs373142747 2768 dbSNP
rs144991079 2770 dbSNP
rs1245475627 2775 dbSNP
rs1194117661 2783 dbSNP
rs942959172 2788 dbSNP
rs78984820 2791 dbSNP
rs191043016 2795 dbSNP
rs552904297 2802 dbSNP
rs572031320 2812 dbSNP
rs1354007442 2817 dbSNP
rs1264696646 2821 dbSNP
rs1245234727 2832 dbSNP
rs1361549216 2833 dbSNP
rs945798615 2838 dbSNP
rs1007652843 2841 dbSNP
rs1445430317 2850 dbSNP
rs149124473 2856 dbSNP
rs10502261 2857 dbSNP
rs902038717 2859 dbSNP
rs1402633835 2887 dbSNP
rs531401819 2888 dbSNP
rs1425665114 2889 dbSNP
rs112563651 2890 dbSNP
rs1031962580 2893 dbSNP
rs1439173057 2900 dbSNP
rs1441740376 2910 dbSNP
rs935812303 2920 dbSNP
rs1328085893 2925 dbSNP
rs956282635 2926 dbSNP
rs1257618552 2928 dbSNP
rs1184060832 2932 dbSNP
rs1056054600 2934 dbSNP
rs990326050 2954 dbSNP
rs183245115 2955 dbSNP
rs1353332023 2957 dbSNP
rs979886943 2985 dbSNP
rs1014609424 2986 dbSNP
rs1239250904 2994 dbSNP
rs186840186 2995 dbSNP
rs1270896136 3001 dbSNP
rs1333428869 3008 dbSNP
rs938554240 3010 dbSNP
rs972977940 3022 dbSNP
rs1405971977 3033 dbSNP
rs1367777887 3049 dbSNP
rs1254396426 3064 dbSNP
rs1435985611 3065 dbSNP
rs1296906421 3066 dbSNP
rs1419681460 3072 dbSNP
rs1386304567 3089 dbSNP
rs190915380 3099 dbSNP
rs556677137 3101 dbSNP
rs1377305906 3115 dbSNP
rs1199801832 3117 dbSNP
rs1481297416 3118 dbSNP
rs547435250 3120 dbSNP
rs1025694038 3123 dbSNP
rs1215624863 3124 dbSNP
rs952790799 3129 dbSNP
rs1048303656 3140 dbSNP
rs559354743 3143 dbSNP
rs1275081923 3144 dbSNP
rs1224911358 3147 dbSNP
rs1471048191 3151 dbSNP
rs1276771138 3157 dbSNP
rs943337226 3160 dbSNP
rs1039142494 3161 dbSNP
rs1320794246 3163 dbSNP
rs1018887442 3173 dbSNP
rs964309567 3176 dbSNP
rs759117369 3178 dbSNP
rs1462218920 3180 dbSNP
rs997728209 3182 dbSNP
rs922265075 3187 dbSNP
rs1421718004 3190 dbSNP
rs891922855 3195 dbSNP
rs1475591523 3198 dbSNP
rs1243810597 3206 dbSNP
rs1185247621 3209 dbSNP
rs1011800916 3211 dbSNP
rs1278788630 3214 dbSNP
rs147839956 3217 dbSNP
rs1398256909 3218 dbSNP
rs977061228 3218 dbSNP
rs1315721191 3219 dbSNP
rs1256999874 3220 dbSNP
rs1218428150 3235 dbSNP
rs925684071 3241 dbSNP
rs1409859035 3244 dbSNP
rs935764964 3250 dbSNP
rs969727030 3253 dbSNP
rs1272434705 3274 dbSNP
rs142343216 3278 dbSNP
rs761647154 3285 dbSNP
rs1337517789 3297 dbSNP
rs1454628227 3307 dbSNP
rs570279069 3312 dbSNP
rs1170192536 3313 dbSNP
rs972476132 3317 dbSNP
rs1421319884 3319 dbSNP
rs764986683 3320 dbSNP
rs1161232294 3323 dbSNP
rs918426371 3331 dbSNP
rs931111207 3333 dbSNP
rs984051979 3339 dbSNP
rs911122551 3346 dbSNP
rs146313350 3353 dbSNP
rs1233574639 3359 dbSNP
rs1308458314 3360 dbSNP
rs1039438033 3369 dbSNP
rs1226935719 3376 dbSNP
rs549126325 3379 dbSNP
rs1356325089 3383 dbSNP
rs923262662 3384 dbSNP
rs1454678485 3411 dbSNP
rs773091392 3420 dbSNP
rs1330954585 3428 dbSNP
rs112376585 3439 dbSNP
rs1356492446 3441 dbSNP
rs897747623 3453 dbSNP
rs1321383647 3454 dbSNP
rs994143842 3469 dbSNP
rs1053106828 3475 dbSNP
rs1336915390 3477 dbSNP
rs1385806158 3481 dbSNP
rs752731153 3483 dbSNP
rs888526698 3486 dbSNP
rs1379092575 3488 dbSNP
rs1177260060 3503 dbSNP
rs148328858 3506 dbSNP
rs1244601304 3510 dbSNP
rs906124053 3519 dbSNP
rs1490277436 3522 dbSNP
rs1293145520 3525 dbSNP
rs1248737169 3526 dbSNP
rs1352137985 3536 dbSNP
rs1308707859 3543 dbSNP
rs762935260 3552 dbSNP
rs183106460 3557 dbSNP
rs964595131 3560 dbSNP
rs1035774116 3564 dbSNP
rs527929109 3568 dbSNP
rs1304893184 3575 dbSNP
rs567198125 3583 dbSNP
rs1417846908 3603 dbSNP
rs141459901 3604 dbSNP
rs1159261244 3609 dbSNP
rs1420305090 3610 dbSNP
rs1371361042 3627 dbSNP
rs1025371188 3635 dbSNP
rs1480323799 3637 dbSNP
rs114418069 3642 dbSNP
rs977030156 3643 dbSNP
rs1487619234 3650 dbSNP
rs760447451 3654 dbSNP
rs577936012 3661 dbSNP
rs911174810 3676 dbSNP
rs575012120 3683 dbSNP
rs557756699 3690 dbSNP
rs1399251166 3698 dbSNP
rs991679696 3707 dbSNP
rs915669262 3710 dbSNP
rs576244939 3717 dbSNP
rs1346372860 3719 dbSNP
rs867980558 3720 dbSNP
rs373174782 3721 dbSNP
rs1289337525 3728 dbSNP
rs1454899448 3739 dbSNP
rs913302298 3744 dbSNP
rs1174733077 3753 dbSNP
rs1377351573 3754 dbSNP
rs1414976016 3765 dbSNP
rs1202111033 3767 dbSNP
rs1477015804 3771 dbSNP
rs1261674298 3777 dbSNP
rs1187543990 3778 dbSNP
rs543253747 3789 dbSNP
rs1203108678 3804 dbSNP
rs1324587093 3806 dbSNP
rs1265179020 3811 dbSNP
rs919146154 3815 dbSNP
rs947597172 3816 dbSNP
rs929236839 3820 dbSNP
rs1047076029 3822 dbSNP
rs1296227146 3826 dbSNP
rs1383913677 3827 dbSNP
rs561835255 3828 dbSNP
rs117932382 3840 dbSNP
rs1226053471 3847 dbSNP
rs906000090 3847 dbSNP
rs541108798 3850 dbSNP
rs1040160261 3859 dbSNP
rs559233200 3860 dbSNP
rs1407868311 3875 dbSNP
rs1270329032 3879 dbSNP
rs1002196206 3890 dbSNP
rs567893403 3893 dbSNP
rs1057361148 3894 dbSNP
rs751013414 3895 dbSNP
rs998287277 3898 dbSNP
rs77931594 3910 dbSNP
rs1183117443 3913 dbSNP
rs1213221397 3917 dbSNP
rs1259916289 3919 dbSNP
rs1461796009 3929 dbSNP
rs1245205724 3937 dbSNP
rs1428205936 3938 dbSNP
rs993822494 3943 dbSNP
rs967593315 3946 dbSNP
rs757412131 3948 dbSNP
rs1251744375 3949 dbSNP
rs878977687 3950 dbSNP
rs1319910000 3959 dbSNP
rs999100269 3961 dbSNP
rs777834851 3965 dbSNP
rs1032669712 3970 dbSNP
rs1384273966 3975 dbSNP
rs1328886594 3976 dbSNP
rs1390515959 3984 dbSNP
rs957226342 3991 dbSNP
rs991172216 3992 dbSNP
rs1254780101 3995 dbSNP
rs767227397 4005 dbSNP
rs1131512 4008 dbSNP
rs1436984386 4010 dbSNP
rs1367269523 4019 dbSNP
rs532790077 4025 dbSNP
rs1163432605 4032 dbSNP
rs971182949 4044 dbSNP
rs1296808459 4050 dbSNP
rs981259618 4058 dbSNP
rs1387224856 4063 dbSNP
rs1382310107 4065 dbSNP
rs1176855009 4070 dbSNP
rs1437506867 4073 dbSNP
rs1381352065 4076 dbSNP
rs1131515 4084 dbSNP
rs150462840 4086 dbSNP
rs1197365185 4087 dbSNP
rs919115262 4092 dbSNP
rs1290948564 4109 dbSNP
rs3180372 4110 dbSNP
rs1005271052 4115 dbSNP
rs1361482860 4123 dbSNP
rs77338539 4131 dbSNP
rs1237663054 4132 dbSNP
rs1336033612 4134 dbSNP
rs1049042018 4139 dbSNP
rs556800375 4141 dbSNP
rs909139911 4150 dbSNP
rs1364041375 4155 dbSNP
rs542000995 4159 dbSNP
rs531189508 4166 dbSNP
rs899888026 4167 dbSNP
rs12294994 4170 dbSNP
rs1469651369 4173 dbSNP
rs1364635255 4175 dbSNP
rs575264609 4176 dbSNP
rs903393786 4184 dbSNP
rs373337746 4185 dbSNP
rs55766389 4192 dbSNP
rs1263894245 4198 dbSNP
rs546684822 4201 dbSNP
Experimental Support 1 for Functional miRNA-Target Interaction
miRNA:Target ----
Validation Method
     
Conditions islets
Tools used in this research TargetScan
Original Description (Extracted from the article) ... HITS-CLIP data was present in Supplenentary. RNA binding protein: AGO. ...

- Kameswaran V; Bramswig NC; McKenna LB; Penn et al., 2014, Cell metabolism.

Article - Kameswaran V; Bramswig NC; McKenna LB; Penn et al.
- Cell metabolism, 2014
Type 2 diabetes mellitus (T2DM) is a complex disease characterized by the inability of the insulin-producing beta cells in the endocrine pancreas to overcome insulin resistance in peripheral tissues. To determine if microRNAs are involved in the pathogenesis of human T2DM, we sequenced the small RNAs of human islets from diabetic and nondiabetic organ donors. We identified a cluster of microRNAs in an imprinted locus on human chromosome 14q32 that is highly and specifically expressed in human beta cells and dramatically downregulated in islets from T2DM organ donors. The downregulation of this locus strongly correlates with hypermethylation of its promoter. Using HITS-CLIP for the essential RISC-component Argonaute, we identified disease-relevant targets of the chromosome 14q32 microRNAs, such as IAPP and TP53INP1, that cause increased beta cell apoptosis upon overexpression in human islets. Our results support a role for microRNAs and their epigenetic control by DNA methylation in the pathogenesis of T2DM.
LinkOut: [PMID: 24374217]
MiRNA-Target Expression Profile
Dataset Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
GSE21687 Ependynoma primary tumors -0.426 2.2e-4 -0.433 1.8e-4 64 Click to see details
GSE28260 Renal cortex and medulla 0.783 7.7e-4 0.676 5.6e-3 13 Click to see details
GSE19783 ER+ ER+ breast cancer 0.471 1.8e-2 0.432 2.9e-2 20 Click to see details
GSE38974 Chronic obstructive pulmonary disease 0.385 2.9e-2 0.296 7.5e-2 25 Click to see details
GSE28544 Breast cancer 0.316 6.6e-2 0.359 4.2e-2 24 Click to see details
GSE19350 CNS germ cell tumors 0.457 6.8e-2 0.510 4.5e-2 12 Click to see details
GSE32688 Pancreatic cancer -0.269 6.8e-2 -0.128 2.4e-1 32 Click to see details
GSE17498 Multiple myeloma -0.23 7.7e-2 -0.226 8.0e-2 40 Click to see details
GSE42095 Differentiated embryonic stem cells 0.273 1.0e-1 0.146 2.5e-1 23 Click to see details
GSE34608 Pulmonary tuberculosis and sarcoidosis 0.211 1.9e-1 -0.301 9.9e-2 20 Click to see details
GSE19783 ER- ER- breast cancer -0.034 3.8e-1 -0.063 2.9e-1 79 Click to see details
GSE38226 Liver fibrosis 0.065 3.9e-1 -0.070 3.8e-1 21 Click to see details
GSE26953 Aortic valvular endothelial cells 0.035 4.4e-1 0.252 1.2e-1 24 Click to see details
GSE19536 Breast cancer 0.007 4.7e-1 0.010 4.6e-1 100 Click to see details
GSE19536 Breast cancer 0.007 4.7e-1 0.010 4.6e-1 100 Click to see details
MiRNA-Target Expression Profile (TCGA)
Tumor Pearson Correlation P-value for Pearson Correlation Spearman Correlation P-value for Spearman Correlation Samples Chart
BLCA 0.488 0.02 0.352 0.08 18 Click to see details
HNSC 0.317 0.02 0.143 0.18 42 Click to see details
THCA 0.253 0.03 0.243 0.03 59 Click to see details
CHOL -0.612 0.04 -0.583 0.05 9 Click to see details
KICH -0.356 0.04 -0.128 0.27 25 Click to see details
STAD 0.263 0.07 0.207 0.13 32 Click to see details
PRAD -0.176 0.11 -0.182 0.1 50 Click to see details
COAD -0.406 0.16 -0.429 0.14 8 Click to see details
KIRP 0.175 0.17 0.262 0.07 32 Click to see details
PAAD 0.638 0.18 0.800 0.1 4 Click to see details
PCPG -0.766 0.22 -0.500 0.33 3 Click to see details
LIHC -0.108 0.23 -0.147 0.16 49 Click to see details
KIRC -0.091 0.23 -0.118 0.17 68 Click to see details
LUAD -0.223 0.24 -0.098 0.38 12 Click to see details
LUSC 0.054 0.37 0.031 0.43 38 Click to see details
ESCA -0.09 0.4 -0.118 0.36 11 Click to see details
BRCA 0.005 0.48 -0.010 0.46 84 Click to see details
UCEC -0.011 0.48 0.054 0.41 19 Click to see details
UCEC -0.011 0.48 0.054 0.41 19 Click to see details
CESC 1 0.5 1.000 0.5 3 Click to see details
CESC 1 0.5 1.000 0.5 3 Click to see details
113 hsa-miR-127-5p Target Genes:
Functional analysis:
ID Target Description Validation methods
Strong evidence Less strong evidence
MIRT380928 ZNF264 zinc finger protein 264 2 2
MIRT439324 USP34 ubiquitin specific peptidase 34 1 1
MIRT439333 USP22 ubiquitin specific peptidase 22 1 1
MIRT439379 TTC37 tetratricopeptide repeat domain 37 1 1
MIRT439445 TMEM116 transmembrane protein 116 1 1
MIRT439498 SYNJ2 synaptojanin 2 1 1
MIRT439525 STBD1 starch binding domain 1 1 1
MIRT439562 SORL1 sortilin related receptor 1 1 1
MIRT439660 SF3B1 splicing factor 3b subunit 1 1 1
MIRT439749 ROGDI rogdi homolog 1 1
MIRT439836 RAB3B RAB3B, member RAS oncogene family 1 1
MIRT439923 PPL periplakin 1 1
MIRT439963 PKD1 polycystin 1, transient receptor potential channel interacting 1 1
MIRT439985 PHKG2 phosphorylase kinase catalytic subunit gamma 2 1 1
MIRT440029 PCLO piccolo presynaptic cytomatrix protein 1 1
MIRT440179 MTRNR2L8 MT-RNR2-like 8 1 1
MIRT440183 MTRNR2L4 MT-RNR2-like 4 1 1
MIRT440184 MTRNR2L6 MT-RNR2-like 6 1 1
MIRT440194 MTRNR2L1 MT-RNR2-like 1 1 1
MIRT440269 MBP myelin basic protein 1 1
MIRT440323 LIN7C lin-7 homolog C, crumbs cell polarity complex component 1 1
MIRT440331 LGALS8 galectin 8 1 1
MIRT440355 KLHL29 kelch like family member 29 1 1
MIRT440397 KDM6B lysine demethylase 6B 1 1
MIRT440411 KAT2B lysine acetyltransferase 2B 1 1
MIRT440424 ITCH itchy E3 ubiquitin protein ligase 1 1
MIRT440651 FBXO7 F-box protein 7 1 1
MIRT440773 DST dystonin 1 1
MIRT440824 DGKD diacylglycerol kinase delta 1 1
MIRT440914 COPA coatomer protein complex subunit alpha 1 1
MIRT441118 BBS4 Bardet-Biedl syndrome 4 1 1
MIRT441153 ATP2A3 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3 1 1
MIRT441193 ARID1A AT-rich interaction domain 1A 1 1
MIRT441260 ADM adrenomedullin 1 1
MIRT441282 ACTB actin beta 1 1
MIRT441306 ABHD2 abhydrolase domain containing 2 1 1
MIRT441860 TEX35 testis expressed 35 2 2
MIRT442190 CCDC132 VPS50, EARP/GARPII complex subunit 2 2
MIRT442886 RHCG Rh family C glycoprotein 2 2
MIRT444158 ZNF701 zinc finger protein 701 2 2
MIRT444506 ZNF525 zinc finger protein 525 2 2
MIRT444770 NAPEPLD N-acyl phosphatidylethanolamine phospholipase D 2 2
MIRT445830 SRSF11 serine and arginine rich splicing factor 11 2 2
MIRT445850 LRRC1 leucine rich repeat containing 1 2 2
MIRT445863 ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 2 2
MIRT446161 C8A complement C8 alpha chain 2 2
MIRT447117 SLFN5 schlafen family member 5 2 2
MIRT447990 CDX1 caudal type homeobox 1 2 2
MIRT449032 ADAMTS5 ADAM metallopeptidase with thrombospondin type 1 motif 5 2 2
MIRT449295 SMIM19 small integral membrane protein 19 2 2
MIRT449541 PCDH9 protocadherin 9 2 2
MIRT449579 ZNF510 zinc finger protein 510 2 2
MIRT450062 SYT9 synaptotagmin 9 2 2
MIRT450437 CAPZA1 capping actin protein of muscle Z-line alpha subunit 1 2 2
MIRT450449 ZDHHC2 zinc finger DHHC-type containing 2 2 2
MIRT450695 RORA RAR related orphan receptor A 2 2
MIRT453654 RAB6C RAB6C, member RAS oncogene family 2 2
MIRT463771 YOD1 YOD1 deubiquitinase 2 2
MIRT468425 SETD1B SET domain containing 1B 2 2
MIRT468843 RRM2 ribonucleotide reductase regulatory subunit M2 2 2
MIRT475594 HMGB2 high mobility group box 2 4 4
MIRT478284 DDX19A DEAD-box helicase 19A 2 2
MIRT487594 NKD2 naked cuticle homolog 2 2 4
MIRT493440 KANSL1 KAT8 regulatory NSL complex subunit 1 2 6
MIRT496169 RPL35A ribosomal protein L35a 2 4
MIRT497566 CCR6 C-C motif chemokine receptor 6 2 2
MIRT497917 BTG1 BTG anti-proliferation factor 1 2 2
MIRT498331 PRELID2 PRELI domain containing 2 2 2
MIRT498369 KLHL11 kelch like family member 11 2 2
MIRT498856 LITAF lipopolysaccharide induced TNF factor 2 2
MIRT505640 SHOC2 SHOC2, leucine rich repeat scaffold protein 2 2
MIRT506128 PLRG1 pleiotropic regulator 1 2 4
MIRT512242 ARPP19 cAMP regulated phosphoprotein 19 2 4
MIRT512489 ARID2 AT-rich interaction domain 2 2 2
MIRT525251 RNF213 ring finger protein 213 2 2
MIRT530197 ALX1 ALX homeobox 1 2 4
MIRT530551 NKIRAS2 NFKB inhibitor interacting Ras like 2 2 2
MIRT534048 STC2 stanniocalcin 2 2 2
MIRT537508 FAM105A family with sequence similarity 105 member A 2 2
MIRT543005 CRK CRK proto-oncogene, adaptor protein 2 2
MIRT543814 SNX10 sorting nexin 10 2 2
MIRT549303 ARID5B AT-rich interaction domain 5B 2 2
MIRT549407 ADIPOR2 adiponectin receptor 2 2 4
MIRT550547 ARSK arylsulfatase family member K 2 2
MIRT554319 SH3GLB1 SH3 domain containing GRB2 like, endophilin B1 2 2
MIRT554515 RUFY2 RUN and FYVE domain containing 2 2 2
MIRT559603 AMOT angiomotin 2 2
MIRT564844 ZBED3 zinc finger BED-type containing 3 2 2
MIRT566125 RAD23B RAD23 homolog B, nucleotide excision repair protein 2 2
MIRT567484 FOXK1 forkhead box K1 2 2
MIRT576521 Txlna taxilin alpha 2 2
MIRT633635 CASC5 kinetochore scaffold 1 2 2
MIRT639325 C9orf41 carnosine N-methyltransferase 1 2 2
MIRT643174 MDM2 MDM2 proto-oncogene 2 2
MIRT651214 ZNF225 zinc finger protein 225 2 2
MIRT653039 STRIP2 striatin interacting protein 2 2 2
MIRT653042 STOX2 storkhead box 2 2 2
MIRT658769 EIF4EBP2 eukaryotic translation initiation factor 4E binding protein 2 2 2
MIRT666728 RALY RALY heterogeneous nuclear ribonucleoprotein 2 2
MIRT681223 DUSP19 dual specificity phosphatase 19 2 2
MIRT685562 SRD5A3 steroid 5 alpha-reductase 3 2 2
MIRT687434 NR3C1 nuclear receptor subfamily 3 group C member 1 2 2
MIRT688439 DNAJC3 DnaJ heat shock protein family (Hsp40) member C3 2 2
MIRT692707 MEAF6 MYST/Esa1 associated factor 6 2 2
MIRT700552 PTBP1 polypyrimidine tract binding protein 1 2 2
MIRT704955 CBX2 chromobox 2 2 2
MIRT714524 ALKBH3 alkB homolog 3, alpha-ketoglutaratedependent dioxygenase 2 2
MIRT716225 DGKI diacylglycerol kinase iota 2 2
MIRT717953 MIA3 MIA family member 3, ER export factor 2 2
MIRT719902 SERP1 stress associated endoplasmic reticulum protein 1 2 2
MIRT732044 BLVRB biliverdin reductase B 3 1
MIRT733622 SNX5 sorting nexin 5 3 0
MIRT737210 CXCR4 C-X-C motif chemokine receptor 4 2 0
miRNA-Drug Associations
miRNA Small Melocule FDA CID Detection Method Condition PMID Year Expression Pattern of miRNA
miR-127 17beta-estradiol (E2) approved 5757 Quantitative real-time PCR rat breast 17700064 2007 down-regulated
miR-127 5-aza-2'-deoxycytidine (5-Aza-CdR) + 4-phenylbutyric acid (PBA) NULL NULL Microarray T24 human bladder cancer cells 16766263 2006 up-regulated
miR-127 17beta-estradiol (E2) approved 5757 Microarray rat breast 17700064 2007 down-regulated
miR-127-5p Glucose NULL 5793 Microarray endothelial cells 24394957 2014 up-regulated
miRNA-Drug Resistance Associations
miRNA Drug Name CID NSC FDA Effect/Pattern Detection Method Level Phenotype Condition
hsa-mir-127 Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-mir-127 Tamoxifen 2733525 NSC180973 approved sensitive cell line (MCF7)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive Low Cervical Cancer tissue
hsa-miR-127-5p Gefitinib 123631 NSC715055 approved resistant cell line (HCC827)
hsa-miR-127-5p Palbociclib 5330286 NSC758247 approved resistant cell line (T47D)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved sensitive cell line (LM11)
hsa-miR-127-5p Vemurafenib 42611257 NSC761431 approved resistant cell line (LM36)
hsa-miR-127-5p 4-Hydroxytamoxifen+Tamoxifen sensitive cell line (LY2)
hsa-miR-127-5p Platinum 23939 resistant tissue (non-small cell lung cancer)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (IGROV-1)
hsa-miR-127-5p Paclitaxel 36314 NSC125973 approved resistant cell line (PC3PR200)
hsa-miR-127-5p Cisplatin 5460033 NSC119875 approved sensitive cell line (A549)

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